DDX11L16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)8.73745963
2thrombin receptor signaling pathway (GO:0070493)8.31350874
3neutrophil activation involved in immune response (GO:0002283)7.26877783
4regulation of platelet activation (GO:0010543)6.03011749
5regulation of platelet aggregation (GO:0090330)6.02832884
6blood coagulation, intrinsic pathway (GO:0007597)6.02591147
7adenosine receptor signaling pathway (GO:0001973)5.79677372
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.58951549
9negative regulation of thymocyte apoptotic process (GO:0070244)5.36300413
10negative regulation of norepinephrine secretion (GO:0010700)5.34734524
11platelet aggregation (GO:0070527)5.24033848
12leukocyte migration involved in inflammatory response (GO:0002523)4.96551303
13purinergic nucleotide receptor signaling pathway (GO:0035590)4.95902253
14G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.89186725
15negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.84685878
16fusion of sperm to egg plasma membrane (GO:0007342)4.83237217
17negative regulation of platelet activation (GO:0010544)4.81457833
18regulation of integrin-mediated signaling pathway (GO:2001044)4.75819460
19lipoxygenase pathway (GO:0019372)4.74563779
20angiogenesis involved in wound healing (GO:0060055)4.66367452
21negative regulation of response to food (GO:0032096)4.61642555
22negative regulation of appetite (GO:0032099)4.61642555
23positive regulation of mast cell activation (GO:0033005)4.59852704
24megakaryocyte development (GO:0035855)4.58760795
25negative regulation of heart rate (GO:0010459)4.57890461
26regulation of Golgi to plasma membrane protein transport (GO:0042996)4.50924316
27positive regulation of endothelial cell differentiation (GO:0045603)4.49515454
28negative regulation of homotypic cell-cell adhesion (GO:0034111)4.49479330
29regulation of female receptivity (GO:0045924)4.43235591
30regulation of integrin activation (GO:0033623)4.42318172
31positive regulation of systemic arterial blood pressure (GO:0003084)4.31320776
32regulation of lipoprotein metabolic process (GO:0050746)4.27751565
33low-density lipoprotein particle remodeling (GO:0034374)4.22471329
34neutrophil activation (GO:0042119)4.14460828
35positive regulation of cAMP-mediated signaling (GO:0043950)4.03919128
36purinergic receptor signaling pathway (GO:0035587)3.96848314
37female mating behavior (GO:0060180)3.80382822
38platelet degranulation (GO:0002576)3.73070792
39negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.71454681
40positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.68666842
41negative regulation of protein localization to cell surface (GO:2000009)3.67353052
42platelet formation (GO:0030220)3.65350701
43granulocyte activation (GO:0036230)3.60514918
44polyamine biosynthetic process (GO:0006596)3.57972045
45homotypic cell-cell adhesion (GO:0034109)3.57309106
46plasma membrane fusion (GO:0045026)3.56527259
47platelet activation (GO:0030168)3.56515961
48positive regulation of Rho protein signal transduction (GO:0035025)3.55076555
49regulation of macrophage derived foam cell differentiation (GO:0010743)3.49356031
50regulation of norepinephrine secretion (GO:0014061)3.47290594
51G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.43124138
52negative regulation of T cell apoptotic process (GO:0070233)3.41705741
53endothelium development (GO:0003158)3.40941069
54aggressive behavior (GO:0002118)3.40311892
55positive regulation of hemostasis (GO:1900048)3.38687303
56positive regulation of blood coagulation (GO:0030194)3.38687303
57regulation of homotypic cell-cell adhesion (GO:0034110)3.37990878
58pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.35695336
59autophagic vacuole fusion (GO:0000046)3.34462834
60negative regulation of heart contraction (GO:0045822)3.34291695
61definitive hemopoiesis (GO:0060216)3.34115967
62negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.32652121
63negative regulation of T-helper cell differentiation (GO:0045623)3.32652121
64mitochondrial calcium ion transport (GO:0006851)3.30263761
65maternal behavior (GO:0042711)3.28420241
66fatty acid elongation (GO:0030497)3.27223544
67beta-amyloid metabolic process (GO:0050435)3.26172521
68negative regulation of catecholamine secretion (GO:0033604)3.24149223
69positive regulation of macrophage differentiation (GO:0045651)3.22897068
70relaxation of smooth muscle (GO:0044557)3.18758348
71high-density lipoprotein particle remodeling (GO:0034375)3.17481481
72negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.13376437
73negative regulation of neural precursor cell proliferation (GO:2000178)3.12891742
74positive regulation of protein homodimerization activity (GO:0090073)3.11171599
75ether lipid metabolic process (GO:0046485)3.11120547
76regulation of histone H3-K9 methylation (GO:0051570)3.09575824
77regulation of memory T cell differentiation (GO:0043380)3.09447719
78regulation of cholesterol efflux (GO:0010874)3.09207149
79regulation of T-helper 1 cell differentiation (GO:0045625)3.04629361
80negative regulation of calcium ion transport into cytosol (GO:0010523)3.04300040
81cellular biogenic amine biosynthetic process (GO:0042401)3.02495838
82regulation of blood coagulation (GO:0030193)3.01592736
83regulation of hemostasis (GO:1900046)3.01592736
84regulation of mast cell activation (GO:0033003)3.01042728
85regulation of endothelial cell differentiation (GO:0045601)3.01040199
86vesicle targeting (GO:0006903)2.99653937
87regulation of MHC class II biosynthetic process (GO:0045346)2.99600231
88positive regulation of granulocyte differentiation (GO:0030854)2.98870729
89deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.98156660
90positive regulation of coagulation (GO:0050820)2.97650898
91microtubule depolymerization (GO:0007019)2.97376302
92cyclooxygenase pathway (GO:0019371)2.96854390
93leukocyte degranulation (GO:0043299)2.96415992
94parental behavior (GO:0060746)2.95853562
95termination of G-protein coupled receptor signaling pathway (GO:0038032)2.93368192
96positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.92451266
97positive regulation of T cell cytokine production (GO:0002726)2.91202948
98regulation of thymocyte apoptotic process (GO:0070243)2.88558617
99negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.87670513
100reverse cholesterol transport (GO:0043691)2.87659456

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human4.99630642
2LYL1_20887958_ChIP-Seq_HPC-7_Mouse4.74872721
3SCL_19346495_ChIP-Seq_HPC-7_Human4.60456976
4EZH2_22144423_ChIP-Seq_EOC_Human3.65375444
5GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.21418114
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.16790697
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.13342625
8RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.05149079
9GATA1_19941826_ChIP-Seq_K562_Human2.96098220
10LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.85660066
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.69057868
12GATA1_22025678_ChIP-Seq_K562_Human2.41008581
13HTT_18923047_ChIP-ChIP_STHdh_Human2.40597933
14GATA2_19941826_ChIP-Seq_K562_Human2.38531092
15GATA1_19941827_ChIP-Seq_MEL_Mouse2.23075580
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.16644202
17GATA2_20887958_ChIP-Seq_HPC-7_Mouse2.15941549
18GBX2_23144817_ChIP-Seq_PC3_Human2.09166075
19GATA1_22383799_ChIP-Seq_G1ME_Mouse2.07131067
20STAT6_21828071_ChIP-Seq_BEAS2B_Human2.04519466
21IKZF1_21737484_ChIP-ChIP_HCT116_Human2.01833585
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.00446529
23IRF8_21731497_ChIP-ChIP_J774_Mouse1.98339986
24TAF15_26573619_Chip-Seq_HEK293_Human1.97105462
25ELK4_26923725_Chip-Seq_MESODERM_Mouse1.89079731
26VDR_22108803_ChIP-Seq_LS180_Human1.88022708
27SPI1_23127762_ChIP-Seq_K562_Human1.87179571
28TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.86971162
29MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.86263805
30GATA2_21666600_ChIP-Seq_HMVEC_Human1.82525650
31Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.81324928
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.79209768
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.77988687
34EWS_26573619_Chip-Seq_HEK293_Human1.73700098
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.68519536
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.66915445
37IGF1R_20145208_ChIP-Seq_DFB_Human1.63875008
38GATA1_19941827_ChIP-Seq_MEL86_Mouse1.63595275
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.63126340
40EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.62776949
41MYB_21317192_ChIP-Seq_ERMYB_Mouse1.61274695
42IRF1_19129219_ChIP-ChIP_H3396_Human1.60967316
43SRY_22984422_ChIP-ChIP_TESTIS_Rat1.50699171
44IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.45666305
45STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.42671196
46RUNX_20019798_ChIP-Seq_JUKART_Human1.37774642
47SALL4_22934838_ChIP-ChIP_CD34+_Human1.35296205
48GATA2_22383799_ChIP-Seq_G1ME_Mouse1.33345056
49PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25495384
50GATA3_21878914_ChIP-Seq_MCF-7_Human1.21442532
51IRF8_27001747_Chip-Seq_BMDM_Mouse1.20795428
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14946497
53ER_23166858_ChIP-Seq_MCF-7_Human1.14586043
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13499228
55FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10068226
56BCAT_22108803_ChIP-Seq_LS180_Human1.08644370
57PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.08062938
58NANOG_20526341_ChIP-Seq_ESCs_Human1.07797750
59SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06810128
60ETS1_22383799_ChIP-Seq_G1ME_Mouse1.06638681
61NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06132183
62NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06132183
63GATA3_26560356_Chip-Seq_TH2_Human1.05760959
64NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02463000
65AR_20517297_ChIP-Seq_VCAP_Human1.01915211
66FOXA1_25329375_ChIP-Seq_VCAP_Human1.01384105
67FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01384105
68HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01290575
69KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.99821042
70EGR1_23403033_ChIP-Seq_LIVER_Mouse0.99351793
71PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98041483
72FLI1_27457419_Chip-Seq_LIVER_Mouse0.95832780
73SPI1_20517297_ChIP-Seq_HL60_Human0.95461273
74FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.95399660
75OCT1_27270436_Chip-Seq_PROSTATE_Human0.95375747
76ERG_20517297_ChIP-Seq_VCAP_Human0.94073000
77GATA3_27048872_Chip-Seq_THYMUS_Human0.93948709
78NANOG_19829295_ChIP-Seq_ESCs_Human0.93477753
79SOX2_19829295_ChIP-Seq_ESCs_Human0.93477753
80FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93221623
81NCOR1_26117541_ChIP-Seq_K562_Human0.91452586
82TDRD3_21172665_ChIP-Seq_MCF-7_Human0.91431958
83E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.91058522
84UTX_26944678_Chip-Seq_JUKART_Human0.89965599
85TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89821745
86TCF4_18268006_ChIP-ChIP_LS174T_Human0.89007402
87LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87739313
88RNF2_27304074_Chip-Seq_NSC_Mouse0.87328774
89ESR1_20079471_ChIP-ChIP_T-47D_Human0.86463432
90SPI1_23547873_ChIP-Seq_NB4_Human0.85841976
91PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.83243235
92SMAD4_21799915_ChIP-Seq_A2780_Human0.83116485
93TP53_22573176_ChIP-Seq_HFKS_Human0.82915170
94AR_25329375_ChIP-Seq_VCAP_Human0.82555516
95RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81099435
96RUNX1_26923725_Chip-Seq_HPCs_Mouse0.80810076
97YY1_22570637_ChIP-Seq_MALME-3M_Human0.80239969
98CTCF_21964334_ChIP-Seq_BJAB-B_Human0.79987579
99GATA3_26560356_Chip-Seq_TH1_Human0.79717454
100BCL6_27268052_Chip-Seq_Bcells_Human0.79614706

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology9.68198273
2MP0008004_abnormal_stomach_pH5.24605427
3MP0000465_gastrointestinal_hemorrhage3.59973392
4MP0003724_increased_susceptibility_to3.55063936
5MP0002736_abnormal_nociception_after2.62574099
6MP0005084_abnormal_gallbladder_morpholo2.26462265
7MP0000230_abnormal_systemic_arterial2.22020872
8MP0004510_myositis2.10143770
9MP0001835_abnormal_antigen_presentation2.06651162
10MP0005646_abnormal_pituitary_gland2.05265366
11MP0008775_abnormal_heart_ventricle2.05152445
12MP0003303_peritoneal_inflammation2.01139314
13MP0000343_altered_response_to1.99530552
14MP0001879_abnormal_lymphatic_vessel1.98837753
15MP0004084_abnormal_cardiac_muscle1.93650987
16MP0001968_abnormal_touch/_nociception1.91174427
17MP0005397_hematopoietic_system_phenotyp1.88077583
18MP0001545_abnormal_hematopoietic_system1.88077583
19MP0005410_abnormal_fertilization1.83396927
20MP0005083_abnormal_biliary_tract1.81268809
21MP0008872_abnormal_physiological_respon1.73375255
22MP0002148_abnormal_hypersensitivity_rea1.70530421
23MP0000015_abnormal_ear_pigmentation1.68856961
24MP0003638_abnormal_response/metabolism_1.67784227
25MP0005167_abnormal_blood-brain_barrier1.65800040
26MP0003718_maternal_effect1.65421507
27MP0001851_eye_inflammation1.64423281
28MP0010155_abnormal_intestine_physiology1.52715993
29MP0005174_abnormal_tail_pigmentation1.52651016
30MP0004130_abnormal_muscle_cell1.51834514
31MP0002398_abnormal_bone_marrow1.44080897
32MP0003828_pulmonary_edema1.44023593
33MP0003136_yellow_coat_color1.41596038
34MP0004036_abnormal_muscle_relaxation1.36930008
35MP0002653_abnormal_ependyma_morphology1.35218167
36MP0002733_abnormal_thermal_nociception1.34374141
37MP0002102_abnormal_ear_morphology1.28922364
38MP0001663_abnormal_digestive_system1.28758425
39MP0005000_abnormal_immune_tolerance1.28241677
40MP0009697_abnormal_copulation1.26171897
41MP0003566_abnormal_cell_adhesion1.26120498
42MP0000249_abnormal_blood_vessel1.25576326
43MP0002132_abnormal_respiratory_system1.25155867
44MP0010368_abnormal_lymphatic_system1.22793483
45MP0004808_abnormal_hematopoietic_stem1.20801012
46MP0001664_abnormal_digestion1.18561175
47MP0009764_decreased_sensitivity_to1.18320704
48MP0005671_abnormal_response_to1.14338064
49MP0008877_abnormal_DNA_methylation1.10175002
50MP0005058_abnormal_lysosome_morphology1.09352296
51MP0009278_abnormal_bone_marrow1.08558989
52MP0003011_delayed_dark_adaptation1.04567283
53MP0000689_abnormal_spleen_morphology1.04322771
54MP0006276_abnormal_autonomic_nervous1.03464525
55MP0009763_increased_sensitivity_to1.02493411
56MP0005409_darkened_coat_color1.01884218
57MP0000383_abnormal_hair_follicle1.00058576
58MP0002429_abnormal_blood_cell0.98340596
59MP0002723_abnormal_immune_serum0.97723026
60MP0003879_abnormal_hair_cell0.97466891
61MP0009765_abnormal_xenobiotic_induced0.96086239
62MP0010329_abnormal_lipoprotein_level0.93800843
63MP0004947_skin_inflammation0.92433026
64MP0002735_abnormal_chemical_nociception0.91967207
65MP0004215_abnormal_myocardial_fiber0.90903360
66MP0009333_abnormal_splenocyte_physiolog0.90674203
67MP0009642_abnormal_blood_homeostasis0.90512647
68MP0001533_abnormal_skeleton_physiology0.88490165
69MP0002722_abnormal_immune_system0.85881736
70MP0001970_abnormal_pain_threshold0.85710120
71MP0002452_abnormal_antigen_presenting0.84102958
72MP0004134_abnormal_chest_morphology0.83302643
73MP0001800_abnormal_humoral_immune0.82943149
74MP0000716_abnormal_immune_system0.82121264
75MP0003436_decreased_susceptibility_to0.82005352
76MP0008874_decreased_physiological_sensi0.80352898
77MP0001765_abnormal_ion_homeostasis0.79044704
78MP0002420_abnormal_adaptive_immunity0.77797669
79MP0005381_digestive/alimentary_phenotyp0.77241312
80MP0001819_abnormal_immune_cell0.75869659
81MP0002638_abnormal_pupillary_reflex0.73953114
82MP0003866_abnormal_defecation0.73861748
83MP0003806_abnormal_nucleotide_metabolis0.72768088
84MP0003698_abnormal_male_reproductive0.72135255
85MP0000490_abnormal_crypts_of0.71246331
86MP0005645_abnormal_hypothalamus_physiol0.71133902
87MP0004484_altered_response_of0.70731939
88MP0006036_abnormal_mitochondrial_physio0.68812898
89MP0006035_abnormal_mitochondrial_morpho0.65798338
90MP0001845_abnormal_inflammatory_respons0.64744157
91MP0001756_abnormal_urination0.64042175
92MP0002128_abnormal_blood_circulation0.63830012
93MP0005535_abnormal_body_temperature0.63812517
94MP0000858_altered_metastatic_potential0.63127181
95MP0009379_abnormal_foot_pigmentation0.62451634
96MP0006138_congestive_heart_failure0.59877813
97MP0005385_cardiovascular_system_phenoty0.59420688
98MP0001544_abnormal_cardiovascular_syste0.59420688
99MP0001929_abnormal_gametogenesis0.59074099
100MP0005165_increased_susceptibility_to0.57635542

Predicted human phenotypes

RankGene SetZ-score
1Menorrhagia (HP:0000132)9.93210985
2Increased mean platelet volume (HP:0011877)9.90295632
3Petechiae (HP:0000967)9.40045938
4Abnormal platelet volume (HP:0011876)9.31975671
5Purpura (HP:0000979)8.40979099
6Epistaxis (HP:0000421)7.65312325
7Gingival bleeding (HP:0000225)6.78559819
8Hyperlipoproteinemia (HP:0010980)5.80675908
9Impaired platelet aggregation (HP:0003540)5.74864716
10Abnormal platelet function (HP:0011869)5.74864716
11Dyschromatopsia (HP:0007641)5.32436025
12Decreased central vision (HP:0007663)4.41285802
13Spontaneous hematomas (HP:0007420)4.16861734
14Poikilocytosis (HP:0004447)4.09475450
15Acanthocytosis (HP:0001927)3.88489049
16Spontaneous abortion (HP:0005268)3.69137610
17Abnormality of the heme biosynthetic pathway (HP:0010472)3.65437779
18Conjunctival telangiectasia (HP:0000524)3.53427994
19Abnormal pupillary function (HP:0007686)3.42659579
20Bruising susceptibility (HP:0000978)3.35372082
21Abnormality of the vasculature of the conjunctiva (HP:0008054)3.18174172
22Paralysis (HP:0003470)3.12836737
23Abnormality of the common coagulation pathway (HP:0010990)3.10389890
24Tinnitus (HP:0000360)2.95012782
25Abnormal auditory evoked potentials (HP:0006958)2.83351876
26Thrombocytosis (HP:0001894)2.72142304
27Abnormality of lateral ventricle (HP:0030047)2.63430323
28Generalized aminoaciduria (HP:0002909)2.56846941
29Papillary thyroid carcinoma (HP:0002895)2.41380033
30Joint hemorrhage (HP:0005261)2.40559790
31Male infertility (HP:0003251)2.36340962
32Increased density of long bones (HP:0006392)2.34495073
33Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.32697358
34Abnormality of alanine metabolism (HP:0010916)2.32697358
35Hyperalaninemia (HP:0003348)2.32697358
36Joint swelling (HP:0001386)2.27454734
37Increased IgM level (HP:0003496)2.27128718
38Stomatitis (HP:0010280)2.26124647
393-Methylglutaconic aciduria (HP:0003535)2.20744144
40Thyroid-stimulating hormone excess (HP:0002925)2.19436875
41Renal Fanconi syndrome (HP:0001994)2.18449315
42Arterial thrombosis (HP:0004420)2.16919201
43Hepatosplenomegaly (HP:0001433)2.13094345
44Xanthomatosis (HP:0000991)2.08206074
45Central scotoma (HP:0000603)2.00815910
46Abnormal ciliary motility (HP:0012262)2.00805490
47Hypophosphatemic rickets (HP:0004912)2.00697652
48Exertional dyspnea (HP:0002875)2.00342748
49Prolonged bleeding time (HP:0003010)11.2848449
50Abnormality of iron homeostasis (HP:0011031)1.99451469
51Nausea (HP:0002018)1.96631275
52Abnormality of transition element cation homeostasis (HP:0011030)1.83098018
53Amaurosis fugax (HP:0100576)1.80660944
54Upper limb muscle weakness (HP:0003484)1.75998255
55Abnormality of the prostate (HP:0008775)1.74069026
56Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.73965958
57Absent rod-and cone-mediated responses on ERG (HP:0007688)1.71908692
58Hyperthyroidism (HP:0000836)1.70328465
59Encephalitis (HP:0002383)1.62057282
60Chest pain (HP:0100749)1.57889232
61Episodic fever (HP:0001954)1.56795161
62Vertigo (HP:0002321)1.56761176
63Thrombophlebitis (HP:0004418)1.55275696
64Abnormality of renal resorption (HP:0011038)1.54944812
65Dynein arm defect of respiratory motile cilia (HP:0012255)1.54898364
66Absent/shortened dynein arms (HP:0200106)1.54898364
67Polyphagia (HP:0002591)1.53742379
68Portal hypertension (HP:0001409)1.53629062
69Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.52766591
70Myelodysplasia (HP:0002863)1.51966982
71Abnormality of macrophages (HP:0004311)1.51545597
72Attenuation of retinal blood vessels (HP:0007843)1.50798692
73Infertility (HP:0000789)1.50378650
74Ventricular fibrillation (HP:0001663)1.49392770
75Thyroid carcinoma (HP:0002890)1.49360642
76Failure to thrive in infancy (HP:0001531)1.49206473
77Autoimmune hemolytic anemia (HP:0001890)1.49144521
78Acute hepatic failure (HP:0006554)1.48284966
79Intellectual disability, profound (HP:0002187)1.48208672
80Abnormality of the hepatic vasculature (HP:0006707)1.48133339
81Renal cortical cysts (HP:0000803)1.47674306
82Abnormal respiratory epithelium morphology (HP:0012253)1.47081282
83Abnormal respiratory motile cilium morphology (HP:0005938)1.47081282
84Tongue fasciculations (HP:0001308)1.46902698
85Basal ganglia calcification (HP:0002135)1.44977467
86Arthropathy (HP:0003040)1.44282755
87Abnormal spermatogenesis (HP:0008669)1.43969397
88Abnormal rod and cone electroretinograms (HP:0008323)1.42893703
89Proximal tubulopathy (HP:0000114)1.41111796
90Abolished electroretinogram (ERG) (HP:0000550)1.40765028
91Ileus (HP:0002595)1.37880286
92Increased serum ferritin (HP:0003281)1.36576847
93Dysautonomia (HP:0002459)1.34250214
94Biliary tract neoplasm (HP:0100574)1.33549307
95Visual hallucinations (HP:0002367)1.33421021
96Congenital stationary night blindness (HP:0007642)1.31228742
97Chronic otitis media (HP:0000389)1.29074613
98Polycythemia (HP:0001901)1.29051335
99Scotoma (HP:0000575)1.26872395
100Congenital, generalized hypertrichosis (HP:0004540)1.25528445

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMX4.22080463
2MST44.13516039
3RIPK43.78026262
4PNCK3.76212810
5TEC3.40756088
6TAOK33.22777155
7MYLK2.99717542
8BTK2.95108424
9MAP4K22.86240768
10PTK2B2.45701267
11CSF1R2.38700970
12ZAK2.37049342
13ACVR1B2.29360153
14NUAK12.08789978
15SYK2.03105662
16PIK3CG1.97938412
17STK31.97490064
18EIF2AK11.82437507
19GRK51.74787359
20ADRBK21.73477404
21FES1.59172458
22TNK21.55457855
23ILK1.52107401
24ZAP701.49975798
25MAPKAPK31.43668886
26BMPR21.42832021
27HCK1.42243189
28TLK11.33666372
29BMPR1B1.27657249
30GRK61.25854385
31MAP2K31.25660888
32FGR1.22955037
33IKBKB1.18560275
34PLK21.11515204
35IRAK11.06680017
36TIE10.97441384
37TNIK0.95949737
38ADRBK10.95581354
39MATK0.95536974
40ITK0.93638448
41LYN0.93441665
42PAK10.86935370
43LMTK20.84818215
44TXK0.84779275
45RET0.84608306
46MUSK0.80501115
47STK240.78673052
48DAPK30.78454881
49JAK30.74891235
50MAP3K50.73479399
51MAP3K130.59988753
52MAP2K10.59324824
53BRSK20.57189800
54FRK0.56986469
55TAF10.56179617
56EPHB20.55805532
57GRK10.55343952
58IRAK20.54108925
59CDC70.52388052
60PRKCQ0.52274758
61BLK0.52117040
62PDK10.52027404
63MARK30.49595926
64LCK0.49287806
65WEE10.49224409
66STK40.49070843
67PDGFRB0.48198538
68TAOK20.45947885
69PKN10.45907480
70MAP4K10.44322875
71ERBB20.44111804
72PRKD10.44037308
73PIM20.42901030
74VRK10.42017862
75PRKG10.41735635
76PDPK10.41140738
77FLT30.40429857
78PRKACG0.39663433
79CDK80.38812142
80DAPK20.38495686
81MAPK130.38487814
82IGF1R0.37834263
83WNK40.35694972
84PIM10.33467224
85TRIM280.31793901
86PRKCA0.30719774
87FER0.30142651
88PRKCD0.30046512
89DAPK10.29155048
90RPS6KA50.27415623
91FYN0.27227875
92PLK30.25550416
93DYRK1A0.23629988
94AURKA0.23024860
95MAP3K20.21594212
96CSK0.21041004
97MAP3K110.20746748
98PRKCG0.20468095
99TGFBR10.19413513
100MET0.18449717

Predicted pathways (KEGG)

RankGene SetZ-score
1Platelet activation_Homo sapiens_hsa046115.89163616
2SNARE interactions in vesicular transport_Homo sapiens_hsa041303.54462409
3Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.95124322
4Arachidonic acid metabolism_Homo sapiens_hsa005902.90142177
5Nitrogen metabolism_Homo sapiens_hsa009102.87887402
6Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.75975555
7Hematopoietic cell lineage_Homo sapiens_hsa046402.35478158
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.27842411
9ECM-receptor interaction_Homo sapiens_hsa045121.99824484
10Linoleic acid metabolism_Homo sapiens_hsa005911.99664482
11Serotonergic synapse_Homo sapiens_hsa047261.97711290
12Vascular smooth muscle contraction_Homo sapiens_hsa042701.89806224
13Gap junction_Homo sapiens_hsa045401.86677056
14Systemic lupus erythematosus_Homo sapiens_hsa053221.65832773
15Olfactory transduction_Homo sapiens_hsa047401.59974019
16Mismatch repair_Homo sapiens_hsa034301.52472226
17Alcoholism_Homo sapiens_hsa050341.51081854
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.51058677
19Chemokine signaling pathway_Homo sapiens_hsa040621.49483867
20Phototransduction_Homo sapiens_hsa047441.40639529
21Glycerolipid metabolism_Homo sapiens_hsa005611.35781684
22Collecting duct acid secretion_Homo sapiens_hsa049661.33322080
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.30253666
24Fatty acid elongation_Homo sapiens_hsa000621.25683070
25Pancreatic secretion_Homo sapiens_hsa049721.20231635
26Long-term depression_Homo sapiens_hsa047301.19634216
27Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.15765533
28Shigellosis_Homo sapiens_hsa051311.13980832
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.05181483
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.02141289
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.00872845
32Glutathione metabolism_Homo sapiens_hsa004800.95462192
33Regulation of actin cytoskeleton_Homo sapiens_hsa048100.94917435
34Sulfur metabolism_Homo sapiens_hsa009200.94495369
35Phospholipase D signaling pathway_Homo sapiens_hsa040720.90871480
36Endocytosis_Homo sapiens_hsa041440.89748564
37Circadian entrainment_Homo sapiens_hsa047130.88000734
38Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87726600
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85987364
40Glycerophospholipid metabolism_Homo sapiens_hsa005640.84924320
41Primary immunodeficiency_Homo sapiens_hsa053400.83374073
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81801932
43B cell receptor signaling pathway_Homo sapiens_hsa046620.81401707
44NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78591952
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77736483
46Regulation of autophagy_Homo sapiens_hsa041400.76383461
47Fat digestion and absorption_Homo sapiens_hsa049750.75094693
48Chemical carcinogenesis_Homo sapiens_hsa052040.74194021
49Calcium signaling pathway_Homo sapiens_hsa040200.73803164
50Rap1 signaling pathway_Homo sapiens_hsa040150.73273399
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69872649
52Fanconi anemia pathway_Homo sapiens_hsa034600.68319276
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68074406
54Purine metabolism_Homo sapiens_hsa002300.67840865
55T cell receptor signaling pathway_Homo sapiens_hsa046600.67438418
56Choline metabolism in cancer_Homo sapiens_hsa052310.67345422
57Morphine addiction_Homo sapiens_hsa050320.65926209
58Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65284408
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63682576
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63660638
61Ras signaling pathway_Homo sapiens_hsa040140.62747335
62Starch and sucrose metabolism_Homo sapiens_hsa005000.60092032
63Retinol metabolism_Homo sapiens_hsa008300.58850661
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57909605
65Sulfur relay system_Homo sapiens_hsa041220.56244386
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.56176332
67Base excision repair_Homo sapiens_hsa034100.55750716
68Asthma_Homo sapiens_hsa053100.53348572
69Ovarian steroidogenesis_Homo sapiens_hsa049130.51353240
70Basal transcription factors_Homo sapiens_hsa030220.49788165
71Viral carcinogenesis_Homo sapiens_hsa052030.49427508
72Phagosome_Homo sapiens_hsa041450.49029794
73Melanoma_Homo sapiens_hsa052180.47987461
74ABC transporters_Homo sapiens_hsa020100.47883391
75Renin secretion_Homo sapiens_hsa049240.46367511
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45521320
77Leukocyte transendothelial migration_Homo sapiens_hsa046700.43064016
78Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42390881
79Malaria_Homo sapiens_hsa051440.41940706
80Ether lipid metabolism_Homo sapiens_hsa005650.41793613
81beta-Alanine metabolism_Homo sapiens_hsa004100.41588578
82Pancreatic cancer_Homo sapiens_hsa052120.40726660
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39330313
84Homologous recombination_Homo sapiens_hsa034400.37827361
85Salivary secretion_Homo sapiens_hsa049700.37676855
86Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.37084767
87Small cell lung cancer_Homo sapiens_hsa052220.36490064
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.36163554
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34980077
90Cholinergic synapse_Homo sapiens_hsa047250.34945096
91One carbon pool by folate_Homo sapiens_hsa006700.34822780
92Focal adhesion_Homo sapiens_hsa045100.33989329
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.32757269
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.32126408
95Pyrimidine metabolism_Homo sapiens_hsa002400.31578435
96Taste transduction_Homo sapiens_hsa047420.29625098
97Renin-angiotensin system_Homo sapiens_hsa046140.29228250
98Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.26966619
99Arginine and proline metabolism_Homo sapiens_hsa003300.26962781
100Pentose phosphate pathway_Homo sapiens_hsa000300.26771891

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