DDX11L5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thrombin receptor signaling pathway (GO:0070493)7.94742281
2protein neddylation (GO:0045116)7.61056300
3adenosine receptor signaling pathway (GO:0001973)6.82933982
4neutrophil activation involved in immune response (GO:0002283)6.23823784
5G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)5.87461262
6purinergic nucleotide receptor signaling pathway (GO:0035590)5.68795372
7regulation of platelet aggregation (GO:0090330)5.54086884
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.35881826
9regulation of platelet activation (GO:0010543)5.13342337
10deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.07630935
11regulation of skeletal muscle contraction (GO:0014819)4.86293791
12positive regulation of protein homodimerization activity (GO:0090073)4.82585570
13blood coagulation, intrinsic pathway (GO:0007597)4.81297191
14lipoxygenase pathway (GO:0019372)4.80797456
15megakaryocyte development (GO:0035855)4.50541159
16purinergic receptor signaling pathway (GO:0035587)4.44607655
17negative regulation of norepinephrine secretion (GO:0010700)4.44057269
18platelet aggregation (GO:0070527)4.27540685
19pyrimidine deoxyribonucleotide metabolic process (GO:0009219)4.14965121
20positive regulation of systemic arterial blood pressure (GO:0003084)4.11631445
21positive regulation of mast cell activation (GO:0033005)4.10444856
22negative regulation of thymocyte apoptotic process (GO:0070244)4.07640065
23leukocyte migration involved in inflammatory response (GO:0002523)4.02384285
24platelet formation (GO:0030220)3.99528887
252-deoxyribonucleotide biosynthetic process (GO:0009265)3.97436728
26deoxyribose phosphate biosynthetic process (GO:0046385)3.97436728
27G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.94179977
28negative regulation of heart rate (GO:0010459)3.91472438
29endothelium development (GO:0003158)3.88653277
30negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.80287407
31ether lipid metabolic process (GO:0046485)3.71070534
32regulation of megakaryocyte differentiation (GO:0045652)3.67976523
33pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.63793730
34regulation of integrin-mediated signaling pathway (GO:2001044)3.63164467
35angiogenesis involved in wound healing (GO:0060055)3.59479255
36negative regulation of platelet activation (GO:0010544)3.57522876
37cyclooxygenase pathway (GO:0019371)3.54650230
38low-density lipoprotein particle remodeling (GO:0034374)3.53357557
39granulocyte differentiation (GO:0030851)3.46041096
40fusion of sperm to egg plasma membrane (GO:0007342)3.45974096
41negative regulation of appetite (GO:0032099)3.34854228
42negative regulation of response to food (GO:0032096)3.34854228
43high-density lipoprotein particle remodeling (GO:0034375)3.34649845
44negative regulation of cell aging (GO:0090344)3.34173100
45neutrophil activation (GO:0042119)3.33720582
46Arp2/3 complex-mediated actin nucleation (GO:0034314)3.32469058
47regulation of mast cell degranulation (GO:0043304)3.26811302
48regulation of mast cell activation involved in immune response (GO:0033006)3.23190166
49cardiolipin metabolic process (GO:0032048)3.21871698
50deoxyribonucleotide catabolic process (GO:0009264)3.21018955
51negative regulation of homotypic cell-cell adhesion (GO:0034111)3.18676649
52negative regulation of T cell apoptotic process (GO:0070233)3.15569731
53negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.14341041
54positive regulation of endothelial cell differentiation (GO:0045603)3.14340983
55positive regulation of mast cell degranulation (GO:0043306)3.12889920
56positive regulation of mast cell activation involved in immune response (GO:0033008)3.12889920
57positive regulation of Rho protein signal transduction (GO:0035025)3.12517012
58pyrimidine nucleotide catabolic process (GO:0006244)3.12497322
59deoxyribose phosphate catabolic process (GO:0046386)3.09338139
60regulation of integrin activation (GO:0033623)3.08350164
61monoamine transport (GO:0015844)3.08304906
62polyamine biosynthetic process (GO:0006596)3.06866313
63grooming behavior (GO:0007625)3.05156628
64reverse cholesterol transport (GO:0043691)3.03668445
65regulation of mast cell activation (GO:0033003)3.02219072
66peptidyl-glutamic acid carboxylation (GO:0017187)3.02007510
67protein carboxylation (GO:0018214)3.02007510
68mitochondrial calcium ion transport (GO:0006851)3.00244674
69sialylation (GO:0097503)2.97672004
70regulation of Golgi to plasma membrane protein transport (GO:0042996)2.96818294
71pyrimidine nucleoside catabolic process (GO:0046135)2.95612030
72regulation of lipoprotein metabolic process (GO:0050746)2.94577840
73granulocyte activation (GO:0036230)2.94356788
74positive regulation of cAMP-mediated signaling (GO:0043950)2.93007570
75positive regulation of macrophage differentiation (GO:0045651)2.92503830
76platelet activation (GO:0030168)2.91757151
77platelet degranulation (GO:0002576)2.91154502
78meiotic chromosome segregation (GO:0045132)2.90052517
79regulation of homotypic cell-cell adhesion (GO:0034110)2.89773761
80negative regulation of protein localization to cell surface (GO:2000009)2.88703636
81adenosine metabolic process (GO:0046085)2.88029078
82beta-amyloid metabolic process (GO:0050435)2.86105283
83homotypic cell-cell adhesion (GO:0034109)2.85338612
84regulation of norepinephrine secretion (GO:0014061)2.84205435
85pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.83977512
86positive regulation of granulocyte differentiation (GO:0030854)2.79687078
87negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.75691312
88purine-containing compound salvage (GO:0043101)2.75473732
89cellular biogenic amine biosynthetic process (GO:0042401)2.74201710
90leukocyte degranulation (GO:0043299)2.73668134
91interkinetic nuclear migration (GO:0022027)2.72285117
92positive regulation of B cell differentiation (GO:0045579)2.72093515
93positive regulation of blood pressure (GO:0045777)2.70217464
94amine biosynthetic process (GO:0009309)2.69355316
95extracellular fibril organization (GO:0043206)2.68564262
96peptide catabolic process (GO:0043171)2.68207485
97poly(A)+ mRNA export from nucleus (GO:0016973)2.66875344
98regulation of macrophage derived foam cell differentiation (GO:0010743)2.66812401
99actin nucleation (GO:0045010)2.66540244
100deoxyribose phosphate metabolic process (GO:0019692)2.65336763

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_19346495_ChIP-Seq_HPC-7_Human4.74709572
2SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human4.21029549
3LYL1_20887958_ChIP-Seq_HPC-7_Mouse4.14663757
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.37189242
5RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.24583007
6GATA1_19941826_ChIP-Seq_K562_Human3.00399593
7IKZF1_21737484_ChIP-ChIP_HCT116_Human2.85076279
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.79732395
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.70047938
10GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.66269815
11LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.64137385
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.54156525
13GATA2_20887958_ChIP-Seq_HPC-7_Mouse2.43278592
14SRY_22984422_ChIP-ChIP_TESTIS_Rat2.37075904
15GATA1_19941827_ChIP-Seq_MEL_Mouse2.35155485
16GATA1_22383799_ChIP-Seq_G1ME_Mouse2.32606548
17VDR_21846776_ChIP-Seq_THP-1_Human2.26838977
18MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.22699171
19GATA2_19941826_ChIP-Seq_K562_Human2.07140992
20VDR_24763502_ChIP-Seq_THP-1_Human2.04162768
21BCL6_27268052_Chip-Seq_Bcells_Human1.99816677
22HTT_18923047_ChIP-ChIP_STHdh_Human1.99784063
23P68_20966046_ChIP-Seq_HELA_Human1.93321758
24CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.89826565
25UTX_26944678_Chip-Seq_JUKART_Human1.86767370
26RUNX1_22412390_ChIP-Seq_EML_Mouse1.85905786
27MAF_26560356_Chip-Seq_TH1_Human1.85513699
28ELK4_26923725_Chip-Seq_MESODERM_Mouse1.82372698
29YY1_22570637_ChIP-Seq_MALME-3M_Human1.79311699
30E2F7_22180533_ChIP-Seq_HELA_Human1.78169062
31BCOR_27268052_Chip-Seq_Bcells_Human1.78083831
32GATA2_21666600_ChIP-Seq_HMVEC_Human1.76086514
33CTCF_21964334_ChIP-Seq_BJAB-B_Human1.75089958
34TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.73551672
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.64731973
36TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.58167637
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.54044412
38ELF1_20517297_ChIP-Seq_JURKAT_Human1.52771716
39SPI1_23127762_ChIP-Seq_K562_Human1.52348406
40GATA1_19941827_ChIP-Seq_MEL86_Mouse1.51818127
41MAF_26560356_Chip-Seq_TH2_Human1.47795400
42NCOR1_26117541_ChIP-Seq_K562_Human1.46535303
43CTCF_21964334_Chip-Seq_Bcells_Human1.45512386
44NANOG_20526341_ChIP-Seq_ESCs_Human1.45070623
45SPI1_20517297_ChIP-Seq_HL60_Human1.44435700
46GATA2_22383799_ChIP-Seq_G1ME_Mouse1.42749685
47CTCF_27219007_Chip-Seq_ERYTHROID_Human1.42569270
48E2F1_20622854_ChIP-Seq_HELA_Human1.38518981
49TAF15_26573619_Chip-Seq_HEK293_Human1.34983014
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33638917
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.33339703
52RARG_19884340_ChIP-ChIP_MEFs_Mouse1.30565949
53SPI1_23547873_ChIP-Seq_NB4_Human1.29777193
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28302019
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.27553645
56IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.26935589
57RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.25567290
58IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.24594946
59FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23947845
60SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.22560903
61SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21933184
62P300_27268052_Chip-Seq_Bcells_Human1.21126755
63IRF1_19129219_ChIP-ChIP_H3396_Human1.21015032
64CTCF_20526341_ChIP-Seq_ESCs_Human1.19673432
65SRF_21415370_ChIP-Seq_HL-1_Mouse1.18187839
66LXR_22292898_ChIP-Seq_THP-1_Human1.18002419
67RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15790932
68IRF8_22096565_ChIP-ChIP_GC-B_Human1.15738624
69MYB_21317192_ChIP-Seq_ERMYB_Mouse1.15492908
70BRD4_27068464_Chip-Seq_AML-cells_Mouse1.15248152
71SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14932138
72PHF8_20622854_ChIP-Seq_HELA_Human1.13153647
73TP53_22573176_ChIP-Seq_HFKS_Human1.12731619
74PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.08944363
75RARA_24833708_ChIP-Seq_LIVER_Mouse1.07705780
76GATA1_22025678_ChIP-Seq_K562_Human1.07204608
77RXRA_24833708_ChIP-Seq_LIVER_Mouse1.07005865
78EWS_26573619_Chip-Seq_HEK293_Human1.06197659
79EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05593856
80SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05342297
81ETS1_22383799_ChIP-Seq_G1ME_Mouse1.04674727
82PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04381937
83GATA3_21867929_ChIP-Seq_CD8_Mouse1.03425780
84GATA3_27048872_Chip-Seq_THYMUS_Human1.03325696
85TAF2_19829295_ChIP-Seq_ESCs_Human1.03096639
86EGR1_23403033_ChIP-Seq_LIVER_Mouse1.01884262
87MYC_22102868_ChIP-Seq_BL_Human1.01791188
88GATA3_21878914_ChIP-Seq_MCF-7_Human1.01008595
89STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00738691
90EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.00127635
91SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99718323
92MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.96797392
93HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96532499
94Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.95907036
95TET1_21451524_ChIP-Seq_MESCs_Mouse0.95301829
96CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92417163
97CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92394178
98IGF1R_20145208_ChIP-Seq_DFB_Human0.92336676
99E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91572752
100CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91438998

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology8.13628972
2MP0008004_abnormal_stomach_pH4.02146107
3MP0005084_abnormal_gallbladder_morpholo3.58062422
4MP0003303_peritoneal_inflammation3.57925507
5MP0001986_abnormal_taste_sensitivity3.19899941
6MP0000465_gastrointestinal_hemorrhage3.08432533
7MP0005174_abnormal_tail_pigmentation2.98214626
8MP0001968_abnormal_touch/_nociception2.97646793
9MP0005171_absent_coat_pigmentation2.79301590
10MP0002736_abnormal_nociception_after2.55322316
11MP0003724_increased_susceptibility_to2.45112205
12MP0003136_yellow_coat_color2.21124798
13MP0001545_abnormal_hematopoietic_system2.20054112
14MP0005397_hematopoietic_system_phenotyp2.20054112
15MP0001835_abnormal_antigen_presentation2.16747013
16MP0005410_abnormal_fertilization2.09614220
17MP0002735_abnormal_chemical_nociception2.02251238
18MP0005083_abnormal_biliary_tract1.98847485
19MP0001188_hyperpigmentation1.90796161
20MP0000230_abnormal_systemic_arterial1.86674834
21MP0004510_myositis1.86567615
22MP0005646_abnormal_pituitary_gland1.80994011
23MP0008872_abnormal_physiological_respon1.79449255
24MP0002148_abnormal_hypersensitivity_rea1.76187536
25MP0001661_extended_life_span1.73260131
26MP0001664_abnormal_digestion1.66497671
27MP0004130_abnormal_muscle_cell1.63642358
28MP0005167_abnormal_blood-brain_barrier1.61164045
29MP0000015_abnormal_ear_pigmentation1.58130117
30MP0002398_abnormal_bone_marrow1.51663026
31MP0009278_abnormal_bone_marrow1.51468956
32MP0004808_abnormal_hematopoietic_stem1.41938302
33MP0000343_altered_response_to1.40158261
34MP0008775_abnormal_heart_ventricle1.38567421
35MP0003806_abnormal_nucleotide_metabolis1.34387129
36MP0009697_abnormal_copulation1.30083163
37MP0010155_abnormal_intestine_physiology1.26866412
38MP0001663_abnormal_digestive_system1.26787834
39MP0002733_abnormal_thermal_nociception1.22875225
40MP0000689_abnormal_spleen_morphology1.19451313
41MP0001756_abnormal_urination1.19168939
42MP0003638_abnormal_response/metabolism_1.19003286
43MP0006036_abnormal_mitochondrial_physio1.18794937
44MP0005409_darkened_coat_color1.14988508
45MP0005423_abnormal_somatic_nervous1.14929687
46MP0005000_abnormal_immune_tolerance1.12868251
47MP0008875_abnormal_xenobiotic_pharmacok1.10643530
48MP0002722_abnormal_immune_system1.09790207
49MP0001851_eye_inflammation1.09484737
50MP0009333_abnormal_splenocyte_physiolog1.09321970
51MP0004084_abnormal_cardiac_muscle1.08257611
52MP0002429_abnormal_blood_cell1.05131991
53MP0002019_abnormal_tumor_incidence1.04301429
54MP0001970_abnormal_pain_threshold1.02247840
55MP0002723_abnormal_immune_serum1.02147155
56MP0008057_abnormal_DNA_replication1.01076131
57MP0001765_abnormal_ion_homeostasis0.99132784
58MP0003656_abnormal_erythrocyte_physiolo0.98149824
59MP0010368_abnormal_lymphatic_system0.97340373
60MP0000490_abnormal_crypts_of0.93950099
61MP0002132_abnormal_respiratory_system0.93630069
62MP0005671_abnormal_response_to0.91543762
63MP0004215_abnormal_myocardial_fiber0.88432410
64MP0000716_abnormal_immune_system0.88271617
65MP0005501_abnormal_skin_physiology0.88212160
66MP0002452_abnormal_antigen_presenting0.87474063
67MP0000358_abnormal_cell_content/0.85792540
68MP0004043_abnormal_pH_regulation0.85651946
69MP0006276_abnormal_autonomic_nervous0.85636399
70MP0002420_abnormal_adaptive_immunity0.85214108
71MP0001879_abnormal_lymphatic_vessel0.84822858
72MP0005058_abnormal_lysosome_morphology0.83134430
73MP0009642_abnormal_blood_homeostasis0.82835683
74MP0003183_abnormal_peptide_metabolism0.82780335
75MP0001905_abnormal_dopamine_level0.82648805
76MP0003763_abnormal_thymus_physiology0.81990856
77MP0001819_abnormal_immune_cell0.81712331
78MP0000249_abnormal_blood_vessel0.81489662
79MP0001800_abnormal_humoral_immune0.80498002
80MP0000703_abnormal_thymus_morphology0.79820335
81MP0010329_abnormal_lipoprotein_level0.79278868
82MP0008874_decreased_physiological_sensi0.79156583
83MP0003436_decreased_susceptibility_to0.78765311
84MP0009763_increased_sensitivity_to0.76159091
85MP0000858_altered_metastatic_potential0.75911359
86MP0003718_maternal_effect0.75463886
87MP0009764_decreased_sensitivity_to0.74891155
88MP0003828_pulmonary_edema0.74360680
89MP0005025_abnormal_response_to0.73018386
90MP0001191_abnormal_skin_condition0.72727759
91MP0005535_abnormal_body_temperature0.72596466
92MP0003448_altered_tumor_morphology0.71179550
93MP0005381_digestive/alimentary_phenotyp0.71120597
94MP0003453_abnormal_keratinocyte_physiol0.70900831
95MP0005332_abnormal_amino_acid0.68728280
96MP0001845_abnormal_inflammatory_respons0.67348560
97MP0003866_abnormal_defecation0.66550705
98MP0006054_spinal_hemorrhage0.62472031
99MP0003172_abnormal_lysosome_physiology0.62089280
100MP0004947_skin_inflammation0.61305228

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)8.86992534
2Petechiae (HP:0000967)7.57097555
3Menorrhagia (HP:0000132)7.49817943
4Increased mean platelet volume (HP:0011877)7.38441003
5Dyschromatopsia (HP:0007641)6.92811464
6Abnormal platelet volume (HP:0011876)6.92364258
7Epistaxis (HP:0000421)6.79278992
8Purpura (HP:0000979)6.35140942
9Gingival bleeding (HP:0000225)5.49397096
10Hyperlipoproteinemia (HP:0010980)4.94142664
11Impaired platelet aggregation (HP:0003540)4.81116335
12Abnormal platelet function (HP:0011869)4.81116335
13Decreased central vision (HP:0007663)4.18526974
14Renal Fanconi syndrome (HP:0001994)3.98606802
15Joint hemorrhage (HP:0005261)3.77780238
16Abnormality of the common coagulation pathway (HP:0010990)3.65057370
17Abnormality of the heme biosynthetic pathway (HP:0010472)3.59390607
18Acanthocytosis (HP:0001927)3.54839007
19Spontaneous abortion (HP:0005268)3.52937276
20Poikilocytosis (HP:0004447)3.51066701
21Attenuation of retinal blood vessels (HP:0007843)3.34015243
22Increased IgM level (HP:0003496)3.04747210
23Exertional dyspnea (HP:0002875)3.00811202
24Spontaneous hematomas (HP:0007420)2.98813412
25Bruising susceptibility (HP:0000978)2.84695948
26Increased intramyocellular lipid droplets (HP:0012240)2.83455463
27Paralysis (HP:0003470)2.75257089
28Testicular atrophy (HP:0000029)2.72567544
29Abnormal pupillary function (HP:0007686)2.72488794
30Tinnitus (HP:0000360)2.71149115
31Hypophosphatemic rickets (HP:0004912)2.70521831
32Facial diplegia (HP:0001349)2.69041497
33Conjunctival telangiectasia (HP:0000524)2.66388271
34Thrombocytosis (HP:0001894)2.58469872
35Increased muscle lipid content (HP:0009058)2.50118874
36Congenital stationary night blindness (HP:0007642)2.47466658
37Choroideremia (HP:0001139)2.45542450
38Abnormality of renal resorption (HP:0011038)2.42770707
39Rib fusion (HP:0000902)2.39110295
40Increased hepatocellular lipid droplets (HP:0006565)2.37046409
41Autoimmune hemolytic anemia (HP:0001890)2.35668781
42Abnormality of the vasculature of the conjunctiva (HP:0008054)2.34881885
43Rectovaginal fistula (HP:0000143)2.32764430
44Rectal fistula (HP:0100590)2.32764430
45Hemorrhage of the eye (HP:0011885)2.27715701
46Male infertility (HP:0003251)2.25959621
47Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.20989179
48Generalized aminoaciduria (HP:0002909)2.20606157
49Mesangial abnormality (HP:0001966)2.19707938
50Facial hemangioma (HP:0000329)2.15491653
51Arterial thrombosis (HP:0004420)2.14651323
52Abnormality of iron homeostasis (HP:0011031)2.14094712
53Decreased electroretinogram (ERG) amplitude (HP:0000654)2.14026263
54Lipid accumulation in hepatocytes (HP:0006561)2.08390803
55Hepatosplenomegaly (HP:0001433)2.07540557
56Abnormality of the hepatic vasculature (HP:0006707)2.06518932
57Abnormality of lateral ventricle (HP:0030047)2.01271085
58Abnormal auditory evoked potentials (HP:0006958)2.00526225
59Vaginal fistula (HP:0004320)1.99027827
60Abnormality of the intrinsic pathway (HP:0010989)1.94757752
61Intestinal fistula (HP:0100819)1.94456739
62Muscle fiber atrophy (HP:0100295)1.93680775
63Joint swelling (HP:0001386)1.93229283
64Dynein arm defect of respiratory motile cilia (HP:0012255)1.92877447
65Absent/shortened dynein arms (HP:0200106)1.92877447
66Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.92707251
67Abnormality of transition element cation homeostasis (HP:0011030)1.92158301
68Amaurosis fugax (HP:0100576)1.84584340
69Prolonged partial thromboplastin time (HP:0003645)1.83754615
70Abnormal ciliary motility (HP:0012262)1.83407744
71Abnormality of the prostate (HP:0008775)1.83365883
72Abnormal respiratory epithelium morphology (HP:0012253)1.79702151
73Abnormal respiratory motile cilium morphology (HP:0005938)1.79702151
74Annular pancreas (HP:0001734)1.79343351
75Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.77892671
76Stomatitis (HP:0010280)1.75904208
77Central scotoma (HP:0000603)1.75748003
78Poikiloderma (HP:0001029)1.74519088
79Abnormality of the costochondral junction (HP:0000919)1.69695902
80Type 2 muscle fiber atrophy (HP:0003554)1.67558237
81Hypertriglyceridemia (HP:0002155)1.66986792
82Absent rod-and cone-mediated responses on ERG (HP:0007688)1.66255568
833-Methylglutaconic aciduria (HP:0003535)1.65472210
84Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.65423388
85Abnormality of alanine metabolism (HP:0010916)1.65211498
86Hyperalaninemia (HP:0003348)1.65211498
87Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.65211498
88Abolished electroretinogram (ERG) (HP:0000550)1.65208709
89Bony spicule pigmentary retinopathy (HP:0007737)1.64387150
90Thrombophlebitis (HP:0004418)1.64172377
91Long clavicles (HP:0000890)1.63844129
92Increased density of long bones (HP:0006392)1.62486264
93Metaphyseal dysplasia (HP:0100255)1.61055355
94Chest pain (HP:0100749)1.60971244
95Atrioventricular block (HP:0001678)1.59707650
96Chorioretinal atrophy (HP:0000533)1.58970359
97Fetal akinesia sequence (HP:0001989)1.57276695
98Chronic otitis media (HP:0000389)1.56581062
99Biliary tract neoplasm (HP:0100574)1.56069284
100Thin bony cortex (HP:0002753)1.55126380

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMX3.40840928
2MST43.38562224
3RIPK43.17664726
4TEC3.06001172
5BTK2.84806402
6MAPK152.77309231
7TESK22.71159008
8MYLK2.57716874
9TAOK32.47753885
10ZAP702.28306863
11FES2.21200770
12EIF2AK12.13884616
13CSF1R2.08080146
14BCKDK2.01232795
15SYK1.94131854
16ACVR1B1.91541642
17MAP2K31.83385958
18WNK41.82319099
19PBK1.76468532
20GRK61.70529930
21GRK51.67494155
22ADRBK21.64309496
23NUAK11.63585720
24PIK3CG1.61320004
25PTK2B1.55588996
26KDR1.53558207
27HCK1.51496271
28STK31.47890734
29ZAK1.46018538
30ILK1.38740665
31SCYL21.38232148
32BLK1.36022262
33CDC71.33025545
34TXK1.25277629
35TNK21.21682155
36TLK11.18606001
37ITK1.18360196
38DAPK21.12439796
39BMPR21.12262242
40ADRBK11.10151310
41IKBKB1.09456150
42VRK11.08363961
43LYN1.08068637
44PAK11.02568109
45FLT30.99616708
46DAPK30.99580142
47VRK20.96326637
48MUSK0.92994614
49PIM20.92352971
50BRSK20.91401011
51MATK0.90545610
52DAPK10.89191942
53MAP3K50.88313013
54MAPK120.86057897
55CCNB10.82279772
56BMPR1B0.81434047
57PRKD10.80429195
58TAOK20.77961494
59CAMKK20.70192224
60PKN10.67091066
61LMTK20.66409728
62MARK30.66155516
63MAP2K60.64424685
64PRKCQ0.64002990
65SIK30.63256687
66LCK0.56641673
67PHKG10.55868856
68PHKG20.55868856
69KIT0.54451429
70MAPKAPK30.54376977
71PRKG20.53011811
72IRAK10.52460154
73MAP4K10.51027989
74TRIM280.49461898
75STK40.48445241
76FER0.47810658
77FGR0.47201926
78GRK10.46860182
79EIF2AK20.46249274
80DYRK1B0.45892777
81PLK20.45442726
82MAP3K110.44629304
83PRKCD0.43279166
84AURKA0.40746053
85MAP3K60.40168122
86EIF2AK30.40160221
87RET0.39923232
88PRKCA0.39638306
89CSK0.38844787
90IRAK20.38181599
91MINK10.37982402
92PDPK10.36787111
93CDK140.35886035
94PRKACG0.35193134
95HIPK20.34767743
96ERBB20.34337896
97DYRK30.31411969
98MAPK130.28953148
99STK390.28170314
100JAK30.26338401

Predicted pathways (KEGG)

RankGene SetZ-score
1Platelet activation_Homo sapiens_hsa046115.19007148
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.98325973
3Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.75862975
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.53077994
5SNARE interactions in vesicular transport_Homo sapiens_hsa041302.46629918
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.39556919
7Mismatch repair_Homo sapiens_hsa034302.32657761
8Arachidonic acid metabolism_Homo sapiens_hsa005902.29286755
9Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.22722938
10Hematopoietic cell lineage_Homo sapiens_hsa046402.14771841
11Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.98185912
12Nitrogen metabolism_Homo sapiens_hsa009101.84274701
13Gap junction_Homo sapiens_hsa045401.68511014
14Base excision repair_Homo sapiens_hsa034101.67599594
15Fatty acid elongation_Homo sapiens_hsa000621.64783792
16Sulfur relay system_Homo sapiens_hsa041221.57796220
17Fanconi anemia pathway_Homo sapiens_hsa034601.55098748
18Vascular smooth muscle contraction_Homo sapiens_hsa042701.50074124
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.49569679
20Serotonergic synapse_Homo sapiens_hsa047261.40377727
21Glycerolipid metabolism_Homo sapiens_hsa005611.33384551
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.32370016
23Primary immunodeficiency_Homo sapiens_hsa053401.32166568
24ECM-receptor interaction_Homo sapiens_hsa045121.29944152
25Sphingolipid metabolism_Homo sapiens_hsa006001.29919282
26Glutathione metabolism_Homo sapiens_hsa004801.25482049
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.25432338
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23791666
29Olfactory transduction_Homo sapiens_hsa047401.13975470
30Linoleic acid metabolism_Homo sapiens_hsa005911.13234743
31Pyrimidine metabolism_Homo sapiens_hsa002401.11826459
32Long-term depression_Homo sapiens_hsa047301.10570953
33Alcoholism_Homo sapiens_hsa050341.09689181
34Systemic lupus erythematosus_Homo sapiens_hsa053221.07423946
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.05253102
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.04680925
37Calcium signaling pathway_Homo sapiens_hsa040201.01137965
38Asthma_Homo sapiens_hsa053100.99452278
39Homologous recombination_Homo sapiens_hsa034400.99298165
40Sulfur metabolism_Homo sapiens_hsa009200.99261054
41Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98086883
42Circadian entrainment_Homo sapiens_hsa047130.97926036
43Purine metabolism_Homo sapiens_hsa002300.94841417
44DNA replication_Homo sapiens_hsa030300.94047462
45Renin secretion_Homo sapiens_hsa049240.93718434
46Endocytosis_Homo sapiens_hsa041440.91890411
47Phototransduction_Homo sapiens_hsa047440.90298461
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.88027889
49Primary bile acid biosynthesis_Homo sapiens_hsa001200.85074673
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84901202
51Shigellosis_Homo sapiens_hsa051310.81764672
52Pancreatic secretion_Homo sapiens_hsa049720.81083762
53Chemokine signaling pathway_Homo sapiens_hsa040620.80208533
54Drug metabolism - other enzymes_Homo sapiens_hsa009830.78715578
55Intestinal immune network for IgA production_Homo sapiens_hsa046720.78509795
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77460586
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77026137
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76697376
59Chemical carcinogenesis_Homo sapiens_hsa052040.75429924
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70348425
61Graft-versus-host disease_Homo sapiens_hsa053320.68698527
62Glycerophospholipid metabolism_Homo sapiens_hsa005640.66907755
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66891604
64Fat digestion and absorption_Homo sapiens_hsa049750.66324635
65Ovarian steroidogenesis_Homo sapiens_hsa049130.62634169
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60683729
67Lysosome_Homo sapiens_hsa041420.59296673
68Allograft rejection_Homo sapiens_hsa053300.58825833
69Autoimmune thyroid disease_Homo sapiens_hsa053200.56147829
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54019164
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53983263
72Taste transduction_Homo sapiens_hsa047420.51330249
73Salivary secretion_Homo sapiens_hsa049700.50870825
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50390458
75NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50012594
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48662714
77Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47986758
78One carbon pool by folate_Homo sapiens_hsa006700.47924123
79Morphine addiction_Homo sapiens_hsa050320.47290259
80Peroxisome_Homo sapiens_hsa041460.43401317
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43333475
82Collecting duct acid secretion_Homo sapiens_hsa049660.42757716
83Fructose and mannose metabolism_Homo sapiens_hsa000510.42059941
84B cell receptor signaling pathway_Homo sapiens_hsa046620.41992174
85Inositol phosphate metabolism_Homo sapiens_hsa005620.41925190
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41580998
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41521111
88ABC transporters_Homo sapiens_hsa020100.40566366
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.38772181
90Starch and sucrose metabolism_Homo sapiens_hsa005000.38601187
91Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.31995218
92Viral carcinogenesis_Homo sapiens_hsa052030.31186062
93Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.31007251
94Staphylococcus aureus infection_Homo sapiens_hsa051500.30778545
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.30347613
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.29550180
97Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.29314316
98Malaria_Homo sapiens_hsa051440.28974214
99Circadian rhythm_Homo sapiens_hsa047100.27248406
100Non-homologous end-joining_Homo sapiens_hsa034500.26856365

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