DDX11L9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)8.24066802
2neutrophil activation involved in immune response (GO:0002283)7.71099959
3thrombin receptor signaling pathway (GO:0070493)7.53401465
4regulation of platelet aggregation (GO:0090330)6.24168297
5adenosine receptor signaling pathway (GO:0001973)5.85974424
6regulation of platelet activation (GO:0010543)5.77018981
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.63943264
8blood coagulation, intrinsic pathway (GO:0007597)5.51961870
9leukocyte migration involved in inflammatory response (GO:0002523)5.39358414
10platelet aggregation (GO:0070527)5.29966013
11negative regulation of thymocyte apoptotic process (GO:0070244)5.27399032
12lipoxygenase pathway (GO:0019372)5.00598123
13negative regulation of homotypic cell-cell adhesion (GO:0034111)4.97349356
14negative regulation of norepinephrine secretion (GO:0010700)4.94151483
15regulation of integrin-mediated signaling pathway (GO:2001044)4.84373901
16negative regulation of heart rate (GO:0010459)4.80041798
17G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.79738795
18negative regulation of platelet activation (GO:0010544)4.77153985
19positive regulation of endothelial cell differentiation (GO:0045603)4.70204456
20purinergic nucleotide receptor signaling pathway (GO:0035590)4.66115113
21neutrophil activation (GO:0042119)4.57009663
22positive regulation of mast cell activation (GO:0033005)4.46851532
23negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.39461178
24low-density lipoprotein particle remodeling (GO:0034374)4.35924701
25negative regulation of response to food (GO:0032096)4.28275519
26negative regulation of appetite (GO:0032099)4.28275519
27positive regulation of cAMP-mediated signaling (GO:0043950)4.20463262
28megakaryocyte development (GO:0035855)4.13206294
29polyamine biosynthetic process (GO:0006596)4.12303677
30fusion of sperm to egg plasma membrane (GO:0007342)4.09993939
31negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)4.09364366
32angiogenesis involved in wound healing (GO:0060055)4.01310126
33granulocyte activation (GO:0036230)4.01164441
34positive regulation of systemic arterial blood pressure (GO:0003084)3.98517646
35negative regulation of protein localization to cell surface (GO:2000009)3.97884159
36positive regulation of macrophage differentiation (GO:0045651)3.97471993
37platelet degranulation (GO:0002576)3.97143262
38regulation of Golgi to plasma membrane protein transport (GO:0042996)3.95760277
39purinergic receptor signaling pathway (GO:0035587)3.94711247
40regulation of integrin activation (GO:0033623)3.87326545
41regulation of MHC class II biosynthetic process (GO:0045346)3.79897954
42platelet formation (GO:0030220)3.76986506
43regulation of homotypic cell-cell adhesion (GO:0034110)3.70465060
44homotypic cell-cell adhesion (GO:0034109)3.69247793
45G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.67524116
46platelet activation (GO:0030168)3.67201288
47positive regulation of Rho protein signal transduction (GO:0035025)3.66389106
48regulation of lipoprotein metabolic process (GO:0050746)3.59423785
49beta-amyloid metabolic process (GO:0050435)3.58715729
50regulation of macrophage derived foam cell differentiation (GO:0010743)3.49238417
51regulation of norepinephrine secretion (GO:0014061)3.44949315
52positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.44025907
53negative regulation of T cell apoptotic process (GO:0070233)3.43303302
54positive regulation of receptor recycling (GO:0001921)3.38367085
55autophagic vacuole fusion (GO:0000046)3.36845363
56negative regulation of heart contraction (GO:0045822)3.33949576
57extracellular fibril organization (GO:0043206)3.32206610
58regulation of female receptivity (GO:0045924)3.31885057
59termination of G-protein coupled receptor signaling pathway (GO:0038032)3.31588107
60negative regulation of neural precursor cell proliferation (GO:2000178)3.29420931
61high-density lipoprotein particle remodeling (GO:0034375)3.28911906
62leukocyte degranulation (GO:0043299)3.24754226
63termination of signal transduction (GO:0023021)3.23126222
64mitochondrial calcium ion transport (GO:0006851)3.21708449
65long-chain fatty acid biosynthetic process (GO:0042759)3.19892264
66regulation of mast cell degranulation (GO:0043304)3.18885506
67positive regulation of hemostasis (GO:1900048)3.18836802
68positive regulation of blood coagulation (GO:0030194)3.18836802
69regulation of mast cell activation (GO:0033003)3.14911105
70regulation of endothelial cell differentiation (GO:0045601)3.12430094
71cyclooxygenase pathway (GO:0019371)3.12402826
72positive regulation of mast cell degranulation (GO:0043306)3.10511062
73positive regulation of mast cell activation involved in immune response (GO:0033008)3.10511062
74cellular biogenic amine biosynthetic process (GO:0042401)3.09975506
75regulation of cholesterol efflux (GO:0010874)3.09909028
76reverse cholesterol transport (GO:0043691)3.09622024
77pyrimidine nucleoside catabolic process (GO:0046135)3.09422599
78regulation of mast cell activation involved in immune response (GO:0033006)3.08590013
79Arp2/3 complex-mediated actin nucleation (GO:0034314)3.08269900
80negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.07826096
81negative regulation of T-helper cell differentiation (GO:0045623)3.07826096
82negative regulation of calcium ion transport into cytosol (GO:0010523)3.04390802
83negative regulation of catecholamine secretion (GO:0033604)2.99227459
84monoamine transport (GO:0015844)2.98701357
85regulation of megakaryocyte differentiation (GO:0045652)2.97292118
86vesicle targeting (GO:0006903)2.96759733
87phospholipid homeostasis (GO:0055091)2.95947390
88plasma membrane fusion (GO:0045026)2.95003172
89negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.93412551
90positive regulation of granulocyte differentiation (GO:0030854)2.93328855
91amine biosynthetic process (GO:0009309)2.92186071
92female mating behavior (GO:0060180)2.90959133
93negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.90363945
94phagocytosis, engulfment (GO:0006911)2.89798905
95endothelium development (GO:0003158)2.88025302
96regulation of memory T cell differentiation (GO:0043380)2.87491205
97cardiolipin metabolic process (GO:0032048)2.83862078
98positive regulation of protein homodimerization activity (GO:0090073)2.83076162
99positive regulation of coagulation (GO:0050820)2.82184572
100negative regulation of protein localization to plasma membrane (GO:1903077)2.82023326

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human5.02427329
2LYL1_20887958_ChIP-Seq_HPC-7_Mouse4.65295325
3SCL_19346495_ChIP-Seq_HPC-7_Human4.30552604
4RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.52930784
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.47613016
6GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.30957805
7GATA1_19941826_ChIP-Seq_K562_Human3.12056253
8EZH2_22144423_ChIP-Seq_EOC_Human3.05466901
9LMO2_20887958_ChIP-Seq_HPC-7_Mouse3.00931887
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.84148405
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.62999383
12GATA1_19941827_ChIP-Seq_MEL_Mouse2.61547633
13GATA2_19941826_ChIP-Seq_K562_Human2.60734414
14SPI1_23127762_ChIP-Seq_K562_Human2.36502741
15GATA2_20887958_ChIP-Seq_HPC-7_Mouse2.35719563
16PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.34389436
17IKZF1_21737484_ChIP-ChIP_HCT116_Human2.33445866
18SRY_22984422_ChIP-ChIP_TESTIS_Rat2.32130613
19Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.31783731
20GATA2_21666600_ChIP-Seq_HMVEC_Human2.28852712
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.28135039
22TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.21131536
23GATA1_22383799_ChIP-Seq_G1ME_Mouse2.19566668
24MYB_21317192_ChIP-Seq_ERMYB_Mouse2.11226913
25MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.08832215
26ELK4_26923725_Chip-Seq_MESODERM_Mouse2.01610874
27HTT_18923047_ChIP-ChIP_STHdh_Human1.97603861
28RUNX1_22412390_ChIP-Seq_EML_Mouse1.96381549
29STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.90376418
30IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.85833195
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77388626
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.76766339
33GATA1_22025678_ChIP-Seq_K562_Human1.74698002
34GBX2_23144817_ChIP-Seq_PC3_Human1.74157436
35IRF8_27001747_Chip-Seq_BMDM_Mouse1.73604021
36NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.68224107
37GATA1_19941827_ChIP-Seq_MEL86_Mouse1.60059765
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58679425
39SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.58316268
40RUNX_20019798_ChIP-Seq_JUKART_Human1.50451284
41PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44110462
42GATA2_22383799_ChIP-Seq_G1ME_Mouse1.39418583
43PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.30271757
44PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29912245
45TAF15_26573619_Chip-Seq_HEK293_Human1.27162282
46FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.22278126
47SPI1_20517297_ChIP-Seq_HL60_Human1.21670136
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.21194736
49KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.19662759
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.15410123
51SPI1_23547873_ChIP-Seq_NB4_Human1.15169175
52NCOR1_26117541_ChIP-Seq_K562_Human1.14443379
53STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14047392
54ETS1_22383799_ChIP-Seq_G1ME_Mouse1.13623254
55NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.12923283
56NRF2_20460467_ChIP-Seq_MEFs_Mouse1.12923283
57SALL4_22934838_ChIP-ChIP_CD34+_Human1.12847329
58UTX_26944678_Chip-Seq_JUKART_Human1.12235083
59BRD4_27068464_Chip-Seq_AML-cells_Mouse1.08775481
60STAT4_19710469_ChIP-ChIP_TH1__Mouse1.06895080
61GATA3_21878914_ChIP-Seq_MCF-7_Human1.05338129
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.05328807
63EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02668540
64STAT1_20625510_ChIP-Seq_HELA_Human1.01055613
65GATA3_27048872_Chip-Seq_THYMUS_Human1.00817105
66SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.00579546
67TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.98750931
68VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94642441
69MYB_26560356_Chip-Seq_TH2_Human0.93999691
70HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93130110
71FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93076898
72GATA3_26560356_Chip-Seq_TH2_Human0.91895832
73OCT1_27270436_Chip-Seq_PROSTATE_Human0.89736782
74VDR_24763502_ChIP-Seq_THP-1_Human0.88777277
75CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87725027
76NANOG_20526341_ChIP-Seq_ESCs_Human0.86963821
77CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86472482
78IRF1_19129219_ChIP-ChIP_H3396_Human0.86095892
79FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.84775278
80VDR_22108803_ChIP-Seq_LS180_Human0.84711379
81LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84324314
82STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.83702379
83EWS_26573619_Chip-Seq_HEK293_Human0.80825414
84SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80698727
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.80225768
86NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.80005202
87ERG_20517297_ChIP-Seq_VCAP_Human0.78910328
88IRF8_22096565_ChIP-ChIP_GC-B_Human0.78635069
89CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78326045
90STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.77952096
91CEBPB_22108803_ChIP-Seq_LS180_Human0.76911215
92JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76566157
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.76296660
94TDRD3_21172665_ChIP-Seq_MCF-7_Human0.76246369
95HOXB4_20404135_ChIP-ChIP_EML_Mouse0.75512215
96SMRT_27268052_Chip-Seq_Bcells_Human0.75271540
97ESR1_20079471_ChIP-ChIP_T-47D_Human0.74662582
98PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.73766192
99PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.73318278
100CTCF_21964334_ChIP-Seq_BJAB-B_Human0.72902893

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology9.85947789
2MP0008004_abnormal_stomach_pH5.42427743
3MP0003724_increased_susceptibility_to3.79485937
4MP0000465_gastrointestinal_hemorrhage3.43428695
5MP0003303_peritoneal_inflammation2.85534855
6MP0005083_abnormal_biliary_tract2.46076842
7MP0001835_abnormal_antigen_presentation2.45997301
8MP0002736_abnormal_nociception_after2.31695424
9MP0000343_altered_response_to2.20901191
10MP0005084_abnormal_gallbladder_morpholo2.19671989
11MP0000230_abnormal_systemic_arterial2.11158752
12MP0004510_myositis1.96611050
13MP0005410_abnormal_fertilization1.87655222
14MP0005671_abnormal_response_to1.77818274
15MP0008872_abnormal_physiological_respon1.77679397
16MP0010155_abnormal_intestine_physiology1.74232859
17MP0003566_abnormal_cell_adhesion1.73476530
18MP0005167_abnormal_blood-brain_barrier1.71292167
19MP0005397_hematopoietic_system_phenotyp1.71105121
20MP0001545_abnormal_hematopoietic_system1.71105121
21MP0002148_abnormal_hypersensitivity_rea1.69783377
22MP0003638_abnormal_response/metabolism_1.69488577
23MP0001879_abnormal_lymphatic_vessel1.67159807
24MP0003828_pulmonary_edema1.66474011
25MP0001968_abnormal_touch/_nociception1.64092853
26MP0005058_abnormal_lysosome_morphology1.56620446
27MP0002132_abnormal_respiratory_system1.56031541
28MP0005000_abnormal_immune_tolerance1.54680247
29MP0002398_abnormal_bone_marrow1.54591126
30MP0004084_abnormal_cardiac_muscle1.54350119
31MP0005646_abnormal_pituitary_gland1.52433985
32MP0001851_eye_inflammation1.52000392
33MP0004130_abnormal_muscle_cell1.44921076
34MP0001663_abnormal_digestive_system1.44646463
35MP0003879_abnormal_hair_cell1.40884452
36MP0008775_abnormal_heart_ventricle1.38043685
37MP0003436_decreased_susceptibility_to1.37745025
38MP0000015_abnormal_ear_pigmentation1.27275261
39MP0002733_abnormal_thermal_nociception1.27061036
40MP0002723_abnormal_immune_serum1.26955860
41MP0004947_skin_inflammation1.25629978
42MP0000249_abnormal_blood_vessel1.22188866
43MP0001800_abnormal_humoral_immune1.21438186
44MP0005174_abnormal_tail_pigmentation1.20153057
45MP0002452_abnormal_antigen_presenting1.15711903
46MP0009764_decreased_sensitivity_to1.14126173
47MP0001533_abnormal_skeleton_physiology1.13903027
48MP0004036_abnormal_muscle_relaxation1.13447170
49MP0003136_yellow_coat_color1.13109535
50MP0000689_abnormal_spleen_morphology1.12808312
51MP0009763_increased_sensitivity_to1.11642647
52MP0002429_abnormal_blood_cell1.10736988
53MP0010329_abnormal_lipoprotein_level1.07660327
54MP0003866_abnormal_defecation1.07339335
55MP0002420_abnormal_adaptive_immunity1.03815628
56MP0001664_abnormal_digestion1.03727305
57MP0001819_abnormal_immune_cell1.02053321
58MP0002722_abnormal_immune_system1.01605711
59MP0008874_decreased_physiological_sensi1.01536468
60MP0000858_altered_metastatic_potential1.00996087
61MP0005409_darkened_coat_color0.98259955
62MP0009642_abnormal_blood_homeostasis0.97069294
63MP0000716_abnormal_immune_system0.96344852
64MP0009765_abnormal_xenobiotic_induced0.95452867
65MP0002419_abnormal_innate_immunity0.95381487
66MP0009278_abnormal_bone_marrow0.94332586
67MP0004215_abnormal_myocardial_fiber0.92413320
68MP0001845_abnormal_inflammatory_respons0.91107908
69MP0009697_abnormal_copulation0.89969727
70MP0001970_abnormal_pain_threshold0.89158722
71MP0005381_digestive/alimentary_phenotyp0.88655442
72MP0005025_abnormal_response_to0.87579620
73MP0000685_abnormal_immune_system0.86673104
74MP0009333_abnormal_splenocyte_physiolog0.86381273
75MP0003300_gastrointestinal_ulcer0.84660429
76MP0001765_abnormal_ion_homeostasis0.82857010
77MP0005666_abnormal_adipose_tissue0.80861406
78MP0006036_abnormal_mitochondrial_physio0.80668200
79MP0006276_abnormal_autonomic_nervous0.80329565
80MP0003656_abnormal_erythrocyte_physiolo0.80056131
81MP0003718_maternal_effect0.78021329
82MP0005387_immune_system_phenotype0.74571957
83MP0001790_abnormal_immune_system0.74571957
84MP0000490_abnormal_crypts_of0.74008593
85MP0000703_abnormal_thymus_morphology0.73343680
86MP0006138_congestive_heart_failure0.73159548
87MP0002735_abnormal_chemical_nociception0.72162646
88MP0005501_abnormal_skin_physiology0.70274835
89MP0005535_abnormal_body_temperature0.69192933
90MP0002998_abnormal_bone_remodeling0.68727832
91MP0001756_abnormal_urination0.67913147
92MP0006054_spinal_hemorrhage0.66633734
93MP0002118_abnormal_lipid_homeostasis0.66304590
94MP0003011_delayed_dark_adaptation0.66140769
95MP0005385_cardiovascular_system_phenoty0.65450928
96MP0001544_abnormal_cardiovascular_syste0.65450928
97MP0005023_abnormal_wound_healing0.63868200
98MP0005365_abnormal_bile_salt0.63862193
99MP0000358_abnormal_cell_content/0.63637165
100MP0002653_abnormal_ependyma_morphology0.63573731

Predicted human phenotypes

RankGene SetZ-score
1Abnormal platelet volume (HP:0011876)9.77112285
2Petechiae (HP:0000967)9.61467316
3Purpura (HP:0000979)8.73828662
4Epistaxis (HP:0000421)7.87359009
5Gingival bleeding (HP:0000225)6.50347192
6Hyperlipoproteinemia (HP:0010980)6.19942958
7Impaired platelet aggregation (HP:0003540)5.64022730
8Abnormal platelet function (HP:0011869)5.64022730
9Dyschromatopsia (HP:0007641)4.57550244
10Spontaneous hematomas (HP:0007420)4.43708019
11Acanthocytosis (HP:0001927)4.14184927
12Poikilocytosis (HP:0004447)4.03920453
13Conjunctival telangiectasia (HP:0000524)3.83563842
14Bruising susceptibility (HP:0000978)3.41731672
15Paralysis (HP:0003470)3.36149806
16Abnormality of the heme biosynthetic pathway (HP:0010472)3.35458041
17Abnormal pupillary function (HP:0007686)3.34991225
18Abnormality of the common coagulation pathway (HP:0010990)3.33386277
19Abnormality of the vasculature of the conjunctiva (HP:0008054)3.32772413
20Abnormality of lateral ventricle (HP:0030047)3.12056451
21Increased density of long bones (HP:0006392)2.94059527
22Decreased central vision (HP:0007663)2.89775264
23Hepatosplenomegaly (HP:0001433)2.71589732
24Increased IgM level (HP:0003496)2.64701725
25Stomatitis (HP:0010280)2.62334726
26Abnormal auditory evoked potentials (HP:0006958)2.57679831
27Joint hemorrhage (HP:0005261)2.55084356
28Joint swelling (HP:0001386)2.51550158
29Abnormality of macrophages (HP:0004311)2.48228747
30Xanthomatosis (HP:0000991)2.37522311
31Tinnitus (HP:0000360)2.31692430
32Spontaneous abortion (HP:0005268)2.30221761
33Upper limb muscle weakness (HP:0003484)2.27870016
34Male infertility (HP:0003251)2.27849042
35Abnormality of iron homeostasis (HP:0011031)2.25154696
36Generalized aminoaciduria (HP:0002909)2.23169196
37Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.16647855
38Papillary thyroid carcinoma (HP:0002895)2.16397776
39Encephalitis (HP:0002383)2.11880378
40Nausea (HP:0002018)2.08783219
41Thyroid-stimulating hormone excess (HP:0002925)2.05505566
42Hypophosphatemic rickets (HP:0004912)2.05382850
43Obstructive lung disease (HP:0006536)2.02310195
44Chronic obstructive pulmonary disease (HP:0006510)2.02310195
45Hyperthyroidism (HP:0000836)2.01753410
46Prolonged bleeding time (HP:0003010)11.7949193
47Menorrhagia (HP:0000132)10.4402718
48Increased mean platelet volume (HP:0011877)10.2964963
49Abnormality of transition element cation homeostasis (HP:0011030)1.99701618
503-Methylglutaconic aciduria (HP:0003535)1.99630490
51Abnormal ciliary motility (HP:0012262)1.99200733
52Arterial thrombosis (HP:0004420)1.95037052
53Dysautonomia (HP:0002459)1.94012747
54Episodic fever (HP:0001954)1.93813034
55Ventricular fibrillation (HP:0001663)1.92171509
56Biliary tract neoplasm (HP:0100574)1.83533732
57Increased serum ferritin (HP:0003281)1.79753295
58Abnormality of the prostate (HP:0008775)1.75148735
59Polycythemia (HP:0001901)1.72071412
60Myocardial infarction (HP:0001658)1.67952281
61Autoimmune hemolytic anemia (HP:0001890)1.64339263
62Infertility (HP:0000789)1.63023563
63Vertigo (HP:0002321)1.62928644
64Absent/shortened dynein arms (HP:0200106)1.62921307
65Dynein arm defect of respiratory motile cilia (HP:0012255)1.62921307
66Abnormal respiratory motile cilium morphology (HP:0005938)1.61128122
67Abnormal respiratory epithelium morphology (HP:0012253)1.61128122
68Basal ganglia calcification (HP:0002135)1.60705145
69Thrombocytosis (HP:0001894)1.59034778
70Eczematoid dermatitis (HP:0000976)1.58450218
71Tongue fasciculations (HP:0001308)1.57278254
72Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.56991868
73Abnormality of alanine metabolism (HP:0010916)1.56028991
74Hyperalaninemia (HP:0003348)1.56028991
75Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.56028991
76Polyphagia (HP:0002591)1.55507253
77Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.54217452
78Chest pain (HP:0100749)1.52408262
79Central scotoma (HP:0000603)1.51539596
80Arthropathy (HP:0003040)1.51530424
81Muscle fibrillation (HP:0010546)1.49059487
82Renal Fanconi syndrome (HP:0001994)1.47338601
83Exertional dyspnea (HP:0002875)1.46035937
84Leiomyosarcoma (HP:0100243)1.45118992
85Uterine leiomyosarcoma (HP:0002891)1.45118992
86Distal lower limb amyotrophy (HP:0008944)1.44458496
87Thrombophlebitis (HP:0004418)1.43584718
88Testicular neoplasm (HP:0010788)1.41183624
89Thyroid carcinoma (HP:0002890)1.39686999
90Transitional cell carcinoma of the bladder (HP:0006740)1.38819430
91Elevated erythrocyte sedimentation rate (HP:0003565)1.38210668
92Inflammation of the large intestine (HP:0002037)1.35379375
93Hypertriglyceridemia (HP:0002155)1.34388512
94Ileus (HP:0002595)1.33207726
95Mucosal telangiectasiae (HP:0100579)1.33064647
96Leukocytosis (HP:0001974)1.32315276
97Cerebral ischemia (HP:0002637)1.30724677
98Abnormal spermatogenesis (HP:0008669)1.30663356
99Abnormality of binocular vision (HP:0011514)1.30522269
100Diplopia (HP:0000651)1.30522269

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.03804603
2MST45.03248444
3BMX4.37206329
4MYLK3.52701288
5TEC3.35539781
6BTK3.19861981
7EIF2AK12.86283584
8TAOK32.76678190
9PTK2B2.72017375
10CSF1R2.36586952
11SYK2.23466750
12GRK52.21557034
13GRK62.18342333
14ZAP702.06367239
15ILK1.91213779
16PIK3CG1.89492598
17BMPR21.79349589
18FGR1.69626364
19TNK21.59292242
20MAPKAPK31.59012565
21ACVR1B1.55352354
22FES1.53445607
23HCK1.49754952
24MAP4K21.42578945
25STK31.40938135
26ADRBK21.40713162
27BLK1.38240881
28MAP2K31.31259889
29LYN1.22295042
30PAK11.20556693
31PLK21.20068100
32PIM21.17995668
33IKBKB1.17846607
34DAPK31.14327651
35LMTK21.11453284
36TLK11.07685171
37TXK1.04052937
38MATK1.03398399
39NUAK11.01594444
40ITK0.94819842
41ADRBK10.92466887
42TNIK0.89242577
43PNCK0.86061418
44ZAK0.84932807
45STK240.82770698
46MAP3K50.81229606
47RET0.80490841
48DAPK20.78461706
49MARK30.78305265
50CSK0.78082155
51IRAK10.78000568
52PRKD10.75074571
53BMPR1B0.74444250
54ARAF0.73583384
55PKN10.70218697
56MAP4K10.69244037
57TAOK20.63672008
58ERBB20.60923165
59EPHA30.59005499
60TESK20.58416563
61MAPK120.57478854
62LCK0.57181749
63FER0.56076451
64PDK10.54436429
65DAPK10.51739269
66TRIM280.48626596
67PRKACG0.48338684
68MAP3K110.48283636
69MAP3K30.47192531
70GRK10.45938019
71PRKCQ0.45339604
72SIK30.44805532
73PDPK10.44441908
74FYN0.44244373
75JAK30.41968364
76STK40.40218896
77MAP2K10.39897952
78MINK10.36408037
79JAK20.35778148
80PRKG10.35403015
81EPHB20.34919266
82PDGFRB0.33870376
83MAPK130.32585169
84PRKCD0.31282938
85DYRK1B0.30715052
86PIM10.30503248
87IRAK40.29900738
88TAOK10.29075199
89CAMKK20.29063110
90PRKCB0.27588180
91PAK30.27005696
92IRAK20.26877556
93PRKCA0.26765333
94IGF1R0.24295371
95SRC0.23651409
96FLT30.23346460
97DYRK1A0.21814260
98CDK140.21773870
99IRAK30.21553887
100EPHB10.20551310

Predicted pathways (KEGG)

RankGene SetZ-score
1Platelet activation_Homo sapiens_hsa046115.65203991
2Pathogenic Escherichia coli infection_Homo sapiens_hsa051303.50043960
3SNARE interactions in vesicular transport_Homo sapiens_hsa041303.20409971
4Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.75260460
5Hematopoietic cell lineage_Homo sapiens_hsa046402.45001226
6Arachidonic acid metabolism_Homo sapiens_hsa005902.38501640
7Nitrogen metabolism_Homo sapiens_hsa009102.08043963
8ECM-receptor interaction_Homo sapiens_hsa045122.06328840
9Chemokine signaling pathway_Homo sapiens_hsa040621.90580441
10Gap junction_Homo sapiens_hsa045401.90145091
11Serotonergic synapse_Homo sapiens_hsa047261.77964047
12Vascular smooth muscle contraction_Homo sapiens_hsa042701.70365149
13Systemic lupus erythematosus_Homo sapiens_hsa053221.61211614
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.54370828
15Alcoholism_Homo sapiens_hsa050341.54211278
16Collecting duct acid secretion_Homo sapiens_hsa049661.53574597
17Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.41811115
18Endocytosis_Homo sapiens_hsa041441.30566925
19B cell receptor signaling pathway_Homo sapiens_hsa046621.27460087
20Glycerolipid metabolism_Homo sapiens_hsa005611.26576831
21Shigellosis_Homo sapiens_hsa051311.25579531
22Linoleic acid metabolism_Homo sapiens_hsa005911.15257517
23Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.14944539
24Pancreatic secretion_Homo sapiens_hsa049721.14850907
25Olfactory transduction_Homo sapiens_hsa047401.14343308
26Regulation of actin cytoskeleton_Homo sapiens_hsa048101.06516414
27Long-term depression_Homo sapiens_hsa047301.04341030
28Sulfur metabolism_Homo sapiens_hsa009201.02628403
29Primary immunodeficiency_Homo sapiens_hsa053401.01355087
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.00438325
31Phospholipase D signaling pathway_Homo sapiens_hsa040721.00369756
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.99919456
33Leukocyte transendothelial migration_Homo sapiens_hsa046700.98545067
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97614280
35T cell receptor signaling pathway_Homo sapiens_hsa046600.96901258
36Mismatch repair_Homo sapiens_hsa034300.95705754
37Circadian entrainment_Homo sapiens_hsa047130.94275733
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.91836397
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90203389
40Glutathione metabolism_Homo sapiens_hsa004800.90044527
41Morphine addiction_Homo sapiens_hsa050320.88901289
42Fatty acid elongation_Homo sapiens_hsa000620.88503325
43Malaria_Homo sapiens_hsa051440.84914366
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.82759954
45Phagosome_Homo sapiens_hsa041450.82716429
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82025807
47Steroid hormone biosynthesis_Homo sapiens_hsa001400.81034491
48Staphylococcus aureus infection_Homo sapiens_hsa051500.76442655
49Graft-versus-host disease_Homo sapiens_hsa053320.76437413
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75258612
51Asthma_Homo sapiens_hsa053100.73707412
52Glycerophospholipid metabolism_Homo sapiens_hsa005640.73444439
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71075591
54Osteoclast differentiation_Homo sapiens_hsa043800.69746868
55Rap1 signaling pathway_Homo sapiens_hsa040150.69539257
56Phototransduction_Homo sapiens_hsa047440.69293176
57Choline metabolism in cancer_Homo sapiens_hsa052310.66438959
58Pancreatic cancer_Homo sapiens_hsa052120.65736830
59Focal adhesion_Homo sapiens_hsa045100.64905404
60Calcium signaling pathway_Homo sapiens_hsa040200.64727412
61Allograft rejection_Homo sapiens_hsa053300.64292714
62Toll-like receptor signaling pathway_Homo sapiens_hsa046200.63107270
63Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63082359
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62817571
65Renin-angiotensin system_Homo sapiens_hsa046140.61079182
66Autoimmune thyroid disease_Homo sapiens_hsa053200.60412789
67Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.60356421
68Starch and sucrose metabolism_Homo sapiens_hsa005000.59327232
69Ras signaling pathway_Homo sapiens_hsa040140.58979377
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57878821
71Viral carcinogenesis_Homo sapiens_hsa052030.57398366
72Regulation of autophagy_Homo sapiens_hsa041400.54844396
73Fat digestion and absorption_Homo sapiens_hsa049750.54387340
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52947902
75Non-small cell lung cancer_Homo sapiens_hsa052230.50702638
76GABAergic synapse_Homo sapiens_hsa047270.50138675
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49949282
78Intestinal immune network for IgA production_Homo sapiens_hsa046720.49606049
79Renin secretion_Homo sapiens_hsa049240.48179244
80Chemical carcinogenesis_Homo sapiens_hsa052040.47872941
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47529116
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46998325
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46910719
84Cholinergic synapse_Homo sapiens_hsa047250.46178731
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44616519
86Sphingolipid metabolism_Homo sapiens_hsa006000.43457931
87Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.42432897
88Small cell lung cancer_Homo sapiens_hsa052220.42298348
89Gastric acid secretion_Homo sapiens_hsa049710.41863755
90Melanoma_Homo sapiens_hsa052180.41376816
91Rheumatoid arthritis_Homo sapiens_hsa053230.41298869
92Endometrial cancer_Homo sapiens_hsa052130.41041467
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40622790
94Apoptosis_Homo sapiens_hsa042100.40094963
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39873756
96beta-Alanine metabolism_Homo sapiens_hsa004100.37218910
97Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36252360
98Salmonella infection_Homo sapiens_hsa051320.34877437
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.34435895
100Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.34134715

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