DDX17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and splicesosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an ATPase activated by a variety of RNA species, but not by dsDNA. This protein, and that encoded by DDX5 gene, are more closely related to each other than to any other member of the DEAD box family. This gene can encode multiple isoforms due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) start codon. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)4.51177718
2negative regulation of cell killing (GO:0031342)4.22997738
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.22997738
4cytoplasmic mRNA processing body assembly (GO:0033962)3.98467418
5negative regulation of erythrocyte differentiation (GO:0045647)3.90364153
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.78668623
7layer formation in cerebral cortex (GO:0021819)3.73735797
8pre-miRNA processing (GO:0031054)3.67080840
9regulation of gamma-delta T cell differentiation (GO:0045586)3.65323264
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.50888447
11regulation of gamma-delta T cell activation (GO:0046643)3.49959335
12insulin-like growth factor receptor signaling pathway (GO:0048009)3.48681576
13negative thymic T cell selection (GO:0045060)3.46335268
14establishment of nucleus localization (GO:0040023)3.41478489
15phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.40002897
16peptidyl-lysine dimethylation (GO:0018027)3.37531827
17cytoskeletal anchoring at plasma membrane (GO:0007016)3.36822693
18negative T cell selection (GO:0043383)3.33897907
19regulation of histone H3-K27 methylation (GO:0061085)3.31783471
20positive thymic T cell selection (GO:0045059)3.31404492
21glucocorticoid receptor signaling pathway (GO:0042921)3.29872627
22regulation of B cell receptor signaling pathway (GO:0050855)3.26179815
23antigen processing and presentation of endogenous antigen (GO:0019883)3.25667499
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.25662879
25positive T cell selection (GO:0043368)3.22394757
26B cell receptor signaling pathway (GO:0050853)3.21699058
27locomotory exploration behavior (GO:0035641)3.13804649
28positive regulation of histone deacetylation (GO:0031065)3.04585247
29sodium ion export (GO:0071436)3.03595187
30thymic T cell selection (GO:0045061)3.00780928
31histone demethylation (GO:0016577)2.99004758
32stress granule assembly (GO:0034063)2.97386139
33negative regulation of myotube differentiation (GO:0010832)2.90105265
34hippo signaling (GO:0035329)2.88883605
35T cell selection (GO:0045058)2.88712994
36response to interleukin-15 (GO:0070672)2.88118638
37NLS-bearing protein import into nucleus (GO:0006607)2.88107435
38glial cell proliferation (GO:0014009)2.87050838
39positive regulation of granulocyte differentiation (GO:0030854)2.86130820
40positive regulation of Rap GTPase activity (GO:0032854)2.85423266
41planar cell polarity pathway involved in neural tube closure (GO:0090179)2.85251208
42regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.84468793
43negative regulation of histone methylation (GO:0031061)2.83046559
44histone H3-K4 trimethylation (GO:0080182)2.81937522
45nuclear pore complex assembly (GO:0051292)2.77646924
46detection of other organism (GO:0098543)2.76717755
47histone H3-K9 demethylation (GO:0033169)2.76570447
48regulation of clathrin-mediated endocytosis (GO:2000369)2.75499710
49negative regulation of lymphocyte mediated immunity (GO:0002707)2.75116158
50corticosteroid receptor signaling pathway (GO:0031958)2.73547211
51gastrulation with mouth forming second (GO:0001702)2.73083160
52embryonic process involved in female pregnancy (GO:0060136)2.73066708
53regulation of RNA export from nucleus (GO:0046831)2.71663021
54mitotic sister chromatid cohesion (GO:0007064)2.68815699
55regulation of Rap GTPase activity (GO:0032317)2.66987565
56response to muramyl dipeptide (GO:0032495)2.66937335
57definitive hemopoiesis (GO:0060216)2.62804025
58activated T cell proliferation (GO:0050798)2.61365832
59detection of bacterium (GO:0016045)2.60746834
60modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.60613087
61positive regulation by organism of defense response of other organism involved in symbiotic interact2.60613087
62modulation by symbiont of host immune response (GO:0052553)2.60613087
63positive regulation by symbiont of host defense response (GO:0052509)2.60613087
64modulation by symbiont of host defense response (GO:0052031)2.60613087
65modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.60613087
66synaptic vesicle maturation (GO:0016188)2.60423715
67adherens junction assembly (GO:0034333)2.58062759
68embryonic camera-type eye morphogenesis (GO:0048596)2.56901106
69positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.55555556
70polarized epithelial cell differentiation (GO:0030859)2.55167596
71dendrite morphogenesis (GO:0048813)2.55084093
72positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.54167788
73regulation of short-term neuronal synaptic plasticity (GO:0048172)2.54152991
74dorsal/ventral axis specification (GO:0009950)2.48265951
75histone H3-K4 methylation (GO:0051568)2.48091690
76epithelial cell differentiation involved in prostate gland development (GO:0060742)2.48079664
77dosage compensation (GO:0007549)2.47961801
78positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.47785797
79protein dealkylation (GO:0008214)2.47757448
80protein demethylation (GO:0006482)2.47757448
81positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.46096909
82regulation of nucleobase-containing compound transport (GO:0032239)2.45083018
83detection of molecule of bacterial origin (GO:0032490)2.44620190
84detection of external biotic stimulus (GO:0098581)2.43157480
85mannose metabolic process (GO:0006013)2.42479695
86heart morphogenesis (GO:0003007)2.42203012
87cellular response to ethanol (GO:0071361)2.42178208
88ectodermal placode formation (GO:0060788)2.41569385
89germinal center formation (GO:0002467)2.41465449
90negative regulation of leukocyte mediated immunity (GO:0002704)2.41265767
91negative regulation of translation, ncRNA-mediated (GO:0040033)2.41107351
92regulation of translation, ncRNA-mediated (GO:0045974)2.41107351
93negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.41107351
94positive regulation of RNA splicing (GO:0033120)2.39884148
95nucleus localization (GO:0051647)2.39480379
96cerebellar Purkinje cell differentiation (GO:0021702)2.39240176
97establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.38874142
98cellular potassium ion homeostasis (GO:0030007)2.37543479
99monoubiquitinated protein deubiquitination (GO:0035520)2.37378559
100interkinetic nuclear migration (GO:0022027)2.37294188
101cellular extravasation (GO:0045123)2.36563596
102regulation of ARF protein signal transduction (GO:0032012)2.35239878
103negative regulation of catenin import into nucleus (GO:0035414)2.35052846
104macrophage activation involved in immune response (GO:0002281)2.34834159
105cell migration in hindbrain (GO:0021535)2.34548375
106histone H4-K16 acetylation (GO:0043984)2.33661647
107embryonic foregut morphogenesis (GO:0048617)2.33596531
108protein localization to endosome (GO:0036010)2.32320827
109regulation of necroptotic process (GO:0060544)2.31432686
110histone H3-K36 demethylation (GO:0070544)2.30776301
111leukocyte aggregation (GO:0070486)2.30048143
112response to epidermal growth factor (GO:0070849)2.29872011
113embryonic retina morphogenesis in camera-type eye (GO:0060059)2.29519465
114hypotonic response (GO:0006971)2.28965714
115regulation of B cell differentiation (GO:0045577)2.28753809
116peptidyl-lysine trimethylation (GO:0018023)2.28553041
117negative regulation of T cell mediated immunity (GO:0002710)2.28534522
118negative regulation of sodium ion transport (GO:0010766)2.28487529
119regulation of establishment of planar polarity (GO:0090175)2.28422081
120negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.28360293
121semaphorin-plexin signaling pathway (GO:0071526)2.27844182
122negative regulation of vascular permeability (GO:0043116)2.27654126
123regulation of granulocyte differentiation (GO:0030852)2.26748499
124Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.26336839
125collecting duct development (GO:0072044)2.25229867
1263-UTR-mediated mRNA stabilization (GO:0070935)2.25222640
127cell communication by electrical coupling (GO:0010644)2.24501759
128cortical actin cytoskeleton organization (GO:0030866)2.24187965
129response to laminar fluid shear stress (GO:0034616)2.24045784
130negative regulation of cell size (GO:0045792)2.23895212
131RNA stabilization (GO:0043489)2.23886991
132mRNA stabilization (GO:0048255)2.23886991
133positive regulation of glycogen biosynthetic process (GO:0045725)2.23447464
134mRNA splice site selection (GO:0006376)2.22774004
135regulation of ARF GTPase activity (GO:0032312)2.22244005
136histone lysine methylation (GO:0034968)2.21168791
137regulation of beta-amyloid formation (GO:1902003)2.21123724
138histone H3-K9 modification (GO:0061647)2.20148914
139cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.19826407
140axonal fasciculation (GO:0007413)2.19382719
141head development (GO:0060322)2.19079480
142nerve growth factor signaling pathway (GO:0038180)2.16538888
143synaptic vesicle docking involved in exocytosis (GO:0016081)2.15888415
144detection of biotic stimulus (GO:0009595)2.15297413
145body morphogenesis (GO:0010171)2.14995219
146peptidyl-threonine phosphorylation (GO:0018107)2.14851946
147neural tube development (GO:0021915)2.14789555
148cellular response to interleukin-15 (GO:0071350)2.14706044
149positive regulation of dendrite morphogenesis (GO:0050775)2.14528891
150histone lysine demethylation (GO:0070076)2.14375039
151regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.14266484
152regulation of tolerance induction (GO:0002643)2.13991180
153clathrin coat assembly (GO:0048268)2.13977241
154nuclear pore organization (GO:0006999)2.13934338
155positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.13925777
156cellular response to epidermal growth factor stimulus (GO:0071364)2.13624656
157activation of protein kinase A activity (GO:0034199)2.13365103
158positive regulation of cellular amide metabolic process (GO:0034250)2.13147537
159peptidyl-threonine modification (GO:0018210)2.12350847
160cell-substrate adherens junction assembly (GO:0007045)2.12345968
161focal adhesion assembly (GO:0048041)2.12345968
162Peyers patch development (GO:0048541)2.12252364
163regulation of axon extension involved in axon guidance (GO:0048841)2.12048366
164regulation of sister chromatid cohesion (GO:0007063)2.11634017
165regulation of catenin import into nucleus (GO:0035412)2.11620711
166regulation of NFAT protein import into nucleus (GO:0051532)2.10735056
167dendritic spine morphogenesis (GO:0060997)2.10029592
168coronary vasculature morphogenesis (GO:0060977)2.09752823
169potassium ion import (GO:0010107)2.07743757
170positive regulation of gene expression, epigenetic (GO:0045815)2.07603850
171positive regulation of hormone biosynthetic process (GO:0046886)2.07273719
172peptidyl-lysine methylation (GO:0018022)2.05980238
173negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.05541588
174positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.04423421
175receptor catabolic process (GO:0032801)2.04175436
176negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.03973807

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.17130572
2ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.80806095
3EGR1_19374776_ChIP-ChIP_THP-1_Human2.72205397
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.60780482
5STAT6_21828071_ChIP-Seq_BEAS2B_Human2.60322601
6WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.43645775
7KDM2B_26808549_Chip-Seq_DND41_Human2.34850978
8MYC_22102868_ChIP-Seq_BL_Human2.30816961
9DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.30601669
10TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.28141401
11ZFP281_27345836_Chip-Seq_ESCs_Mouse2.23300188
12FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.23136969
13RUNX_20019798_ChIP-Seq_JUKART_Human2.22467573
14* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.17814115
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.15902509
16ZFP281_18757296_ChIP-ChIP_E14_Mouse2.15781931
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.07764539
18KDM2B_26808549_Chip-Seq_K562_Human2.07242587
19* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.06450424
20EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.05924697
21KDM2B_26808549_Chip-Seq_JURKAT_Human2.02080782
22TCF7_22412390_ChIP-Seq_EML_Mouse2.00040870
23GATA1_22025678_ChIP-Seq_K562_Human1.98401577
24DROSHA_22980978_ChIP-Seq_HELA_Human1.95536233
25KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.92750039
26SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.92437649
27SCL_19346495_ChIP-Seq_HPC-7_Human1.86525651
28* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.84874696
29MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.82298039
30EZH2_22144423_ChIP-Seq_EOC_Human1.80485873
31FOXM1_23109430_ChIP-Seq_U2OS_Human1.79060259
32RBPJ_22232070_ChIP-Seq_NCS_Mouse1.78328270
33SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.70738689
34RARB_27405468_Chip-Seq_BRAIN_Mouse1.67530060
35P300_27058665_Chip-Seq_ZR-75-30cells_Human1.64709506
36NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.63742071
37FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.62096588
38MYB_21317192_ChIP-Seq_ERMYB_Mouse1.61286440
39* MAF_26560356_Chip-Seq_TH1_Human1.60180279
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.58792584
41VDR_24763502_ChIP-Seq_THP-1_Human1.58555128
42ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.58454235
43CLOCK_20551151_ChIP-Seq_293T_Human1.57094866
44* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.55561121
45ISL1_27105846_Chip-Seq_CPCs_Mouse1.51518874
46SPI1_23127762_ChIP-Seq_K562_Human1.50202468
47IRF8_27001747_Chip-Seq_BMDM_Mouse1.48811961
48EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.48313556
49* SALL1_21062744_ChIP-ChIP_HESCs_Human1.47697690
50NFIB_24661679_ChIP-Seq_LUNG_Mouse1.47562492
51WT1_25993318_ChIP-Seq_PODOCYTE_Human1.47000880
52MYB_26560356_Chip-Seq_TH2_Human1.45084036
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.41753943
54ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.41050728
55EZH2_18974828_ChIP-Seq_MESCs_Mouse1.40849888
56RNF2_18974828_ChIP-Seq_MESCs_Mouse1.40849888
57PKCTHETA_26484144_Chip-Seq_BREAST_Human1.40031764
58KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.39045947
59MYB_26560356_Chip-Seq_TH1_Human1.36226951
60ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.35470690
61THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34344548
62E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.34206940
63STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.33303904
64ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32367017
65BRD4_27068464_Chip-Seq_AML-cells_Mouse1.31523053
66ELK3_25401928_ChIP-Seq_HUVEC_Human1.30233364
67CREB1_26743006_Chip-Seq_LNCaP_Human1.28993738
68GATA1_19941827_ChIP-Seq_MEL_Mouse1.28866705
69HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.28409428
70IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.26099493
71VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25441089
72AR_21572438_ChIP-Seq_LNCaP_Human1.25056313
73GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25029499
74RUNX1_22412390_ChIP-Seq_EML_Mouse1.23879284
75STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22834580
76AHR_22903824_ChIP-Seq_MCF-7_Human1.21139325
77RING1B_27294783_Chip-Seq_NPCs_Mouse1.20408530
78CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19681045
79CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.19181646
80VDR_21846776_ChIP-Seq_THP-1_Human1.18674581
81FOXO3_23340844_ChIP-Seq_DLD1_Human1.18256475
82RNF2_27304074_Chip-Seq_ESCs_Mouse1.17988923
83SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.17023270
84ZNF263_19887448_ChIP-Seq_K562_Human1.16271940
85Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.15769453
86BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15413067
87ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.14492709
88ARNT_22903824_ChIP-Seq_MCF-7_Human1.13019807
89TP53_16413492_ChIP-PET_HCT116_Human1.12937256
90VDR_24787735_ChIP-Seq_THP-1_Human1.12851775
91RUNX1_27514584_Chip-Seq_MCF-7_Human1.12659998
92WT1_19549856_ChIP-ChIP_CCG9911_Human1.12641362
93KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10906466
94JARID2_20064375_ChIP-Seq_MESCs_Mouse1.10883882
95MTF2_20144788_ChIP-Seq_MESCs_Mouse1.10176881
96LXR_22292898_ChIP-Seq_THP-1_Human1.09920219
97AR_19668381_ChIP-Seq_PC3_Human1.08786533
98* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.08101488
99CTNNB1_20460455_ChIP-Seq_HCT116_Human1.07693238
100FOXA2_19822575_ChIP-Seq_HepG2_Human1.07290368
101ESR2_21235772_ChIP-Seq_MCF-7_Human1.07154994
102GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06455087
103DNAJC2_21179169_ChIP-ChIP_NT2_Human1.05220326
104RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05185167
105ERG_21242973_ChIP-ChIP_JURKAT_Human1.04570880
106RING1B_27294783_Chip-Seq_ESCs_Mouse1.03542450
107FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.02881415
108GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.02819478
109GATA2_19941826_ChIP-Seq_K562_Human1.02518050
110JARID2_20075857_ChIP-Seq_MESCs_Mouse1.00918311
111YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00682325
112GATA3_27048872_Chip-Seq_THYMUS_Human1.00400154
113TBX3_20139965_ChIP-Seq_ESCs_Mouse1.00324887
114MAF_26560356_Chip-Seq_TH2_Human1.00206989
115TBX3_20139965_ChIP-Seq_MESCs_Mouse1.00034369
116MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99451727
117ESR1_20079471_ChIP-ChIP_T-47D_Human0.99017770
118FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.98148712
119GATA1_19941827_ChIP-Seq_MEL86_Mouse0.98078291
120PU_27001747_Chip-Seq_BMDM_Mouse0.97216680
121RACK7_27058665_Chip-Seq_MCF-7_Human0.96518691
122TCF4_18268006_ChIP-ChIP_LS174T_Human0.96122613
123IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94886649
124SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94869229
125GATA1_19941826_ChIP-Seq_K562_Human0.94639511
126SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94561683
127TBX20_22080862_ChIP-Seq_HEART_Mouse0.94436812
128SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94165828
129SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.93090454
130UTX_26944678_Chip-Seq_JUKART_Human0.93063862
131* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.92623798
132SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.92432078
133* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.91962763
134ZNF274_21170338_ChIP-Seq_K562_Hela0.91828360
135SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.91166861
136OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.90928277
137RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.90526585
138ESR1_15608294_ChIP-ChIP_MCF-7_Human0.90388927
139EZH2_27304074_Chip-Seq_ESCs_Mouse0.90226533
140CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89861182
141BP1_19119308_ChIP-ChIP_Hs578T_Human0.89733151
142TBX20_22328084_ChIP-Seq_HEART_Mouse0.89697889
143ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.86320039
144KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.85219599

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002009_preneoplasia3.90362819
2MP0000569_abnormal_digit_pigmentation3.52403079
3MP0003705_abnormal_hypodermis_morpholog3.31254703
4MP0010234_abnormal_vibrissa_follicle3.23211761
5MP0003763_abnormal_thymus_physiology3.13844612
6MP0002396_abnormal_hematopoietic_system3.08829466
7MP0008057_abnormal_DNA_replication3.08116779
8MP0000537_abnormal_urethra_morphology2.74740494
9MP0003283_abnormal_digestive_organ2.70803593
10MP0005076_abnormal_cell_differentiation2.66151776
11MP0005409_darkened_coat_color2.57268459
12MP0004859_abnormal_synaptic_plasticity2.51800067
13MP0005187_abnormal_penis_morphology2.26917178
14MP0003690_abnormal_glial_cell2.10790636
15MP0002166_altered_tumor_susceptibility2.05749334
16MP0001835_abnormal_antigen_presentation2.05245668
17MP0003300_gastrointestinal_ulcer2.00092239
18MP0010352_gastrointestinal_tract_polyps1.94231665
19MP0000733_abnormal_muscle_development1.92048517
20MP0005623_abnormal_meninges_morphology1.91801907
21MP0008961_abnormal_basal_metabolism1.90599656
22MP0003724_increased_susceptibility_to1.89364275
23MP0003436_decreased_susceptibility_to1.86664410
24MP0001849_ear_inflammation1.84794097
25MP0003122_maternal_imprinting1.83809395
26MP0000428_abnormal_craniofacial_morphol1.79913448
27MP0009780_abnormal_chondrocyte_physiolo1.79541052
28MP0000703_abnormal_thymus_morphology1.78211523
29MP0001800_abnormal_humoral_immune1.75733329
30MP0004381_abnormal_hair_follicle1.72348449
31MP0004885_abnormal_endolymph1.71176674
32MP0009278_abnormal_bone_marrow1.66722629
33MP0003121_genomic_imprinting1.64630117
34MP0003123_paternal_imprinting1.63084545
35MP0003787_abnormal_imprinting1.62639487
36MP0004233_abnormal_muscle_weight1.60415171
37MP0003115_abnormal_respiratory_system1.60156027
38MP0003828_pulmonary_edema1.58678948
39MP0001851_eye_inflammation1.54406178
40MP0001299_abnormal_eye_distance/1.52886227
41MP0003935_abnormal_craniofacial_develop1.51748498
42MP0002398_abnormal_bone_marrow1.51563699
43MP0003045_fibrosis1.48193279
44MP0008260_abnormal_autophagy1.46277155
45MP0003385_abnormal_body_wall1.45944520
46MP0000534_abnormal_ureter_morphology1.45710680
47MP0004197_abnormal_fetal_growth/weight/1.42964170
48MP0010030_abnormal_orbit_morphology1.41541059
49MP0004272_abnormal_basement_membrane1.39788166
50MP0010678_abnormal_skin_adnexa1.39570001
51MP0009053_abnormal_anal_canal1.38996601
52MP0002084_abnormal_developmental_patter1.37484426
53MP0002405_respiratory_system_inflammati1.36599813
54MP0003866_abnormal_defecation1.35032366
55MP0005248_abnormal_Harderian_gland1.33778800
56MP0002420_abnormal_adaptive_immunity1.33097714
57MP0005387_immune_system_phenotype1.31958386
58MP0001790_abnormal_immune_system1.31958386
59MP0004858_abnormal_nervous_system1.31933028
60MP0009703_decreased_birth_body1.29744418
61MP0001819_abnormal_immune_cell1.29660148
62MP0006072_abnormal_retinal_apoptosis1.28200679
63MP0004947_skin_inflammation1.28044444
64MP0000685_abnormal_immune_system1.26772418
65MP0003119_abnormal_digestive_system1.26374970
66MP0000566_synostosis1.25018880
67MP0002419_abnormal_innate_immunity1.24603761
68MP0002133_abnormal_respiratory_system1.23526146
69MP0005388_respiratory_system_phenotype1.23526146
70MP0003172_abnormal_lysosome_physiology1.22652529
71MP0002092_abnormal_eye_morphology1.21786048
72MP0000716_abnormal_immune_system1.21165886
73MP0004185_abnormal_adipocyte_glucose1.21041823
74MP0000778_abnormal_nervous_system1.20172891
75MP0003635_abnormal_synaptic_transmissio1.19665979
76MP0002089_abnormal_postnatal_growth/wei1.18622573
77* MP0002925_abnormal_cardiovascular_devel1.17863442
78MP0002234_abnormal_pharynx_morphology1.17572404
79MP0003091_abnormal_cell_migration1.17527324
80MP0002653_abnormal_ependyma_morphology1.16006989
81MP0003861_abnormal_nervous_system1.15647140
82MP0002723_abnormal_immune_serum1.14928865
83MP0005025_abnormal_response_to1.14542911
84MP0002722_abnormal_immune_system1.14344147
85MP0002998_abnormal_bone_remodeling1.13266312
86MP0001293_anophthalmia1.12636170
87MP0005666_abnormal_adipose_tissue1.12242399
88MP0003942_abnormal_urinary_system1.10555035
89MP0005000_abnormal_immune_tolerance1.10545662
90MP0003566_abnormal_cell_adhesion1.09818517
91MP0010155_abnormal_intestine_physiology1.08946341
92MP0002452_abnormal_antigen_presenting1.08688934
93MP0000003_abnormal_adipose_tissue1.08207543
94MP0002006_tumorigenesis1.07738797
95MP0002249_abnormal_larynx_morphology1.06034540
96MP0002697_abnormal_eye_size1.05746522
97MP0003183_abnormal_peptide_metabolism1.05543712
98MP0003937_abnormal_limbs/digits/tail_de1.05463550
99MP0002086_abnormal_extraembryonic_tissu1.04589688
100MP0002085_abnormal_embryonic_tissue1.03640767
101MP0009672_abnormal_birth_weight1.03183033
102MP0008438_abnormal_cutaneous_collagen1.02936127
103MP0004130_abnormal_muscle_cell1.02394291
104MP0010630_abnormal_cardiac_muscle1.00788154
105MP0003567_abnormal_fetal_cardiomyocyte0.98734712
106MP0003890_abnormal_embryonic-extraembry0.97939272
107MP0006054_spinal_hemorrhage0.97626877
108MP0002932_abnormal_joint_morphology0.97246539
109MP0005367_renal/urinary_system_phenotyp0.96679627
110MP0000516_abnormal_urinary_system0.96679627
111MP0000689_abnormal_spleen_morphology0.95882047
112MP0002909_abnormal_adrenal_gland0.94890892
113MP0005621_abnormal_cell_physiology0.94857256
114MP0002896_abnormal_bone_mineralization0.93358801
115MP0004808_abnormal_hematopoietic_stem0.93173402
116MP0002152_abnormal_brain_morphology0.92700824
117MP0000465_gastrointestinal_hemorrhage0.92351242
118MP0002429_abnormal_blood_cell0.91825540
119MP0008770_decreased_survivor_rate0.91161927
120MP0005391_vision/eye_phenotype0.90643308
121MP0005397_hematopoietic_system_phenotyp0.90609985
122MP0001545_abnormal_hematopoietic_system0.90609985
123MP0003329_amyloid_beta_deposits0.90348019
124MP0004883_abnormal_blood_vessel0.90305089
125MP0000432_abnormal_head_morphology0.89925057
126MP0005375_adipose_tissue_phenotype0.89162732
127MP0003453_abnormal_keratinocyte_physiol0.89142331
128MP0003303_peritoneal_inflammation0.88996047
129MP0002088_abnormal_embryonic_growth/wei0.88758774
130MP0001958_emphysema0.87882308
131MP0003632_abnormal_nervous_system0.87808090
132MP0004811_abnormal_neuron_physiology0.87630370
133MP0001177_atelectasis0.87061842
134MP0001784_abnormal_fluid_regulation0.86128567
135MP0002116_abnormal_craniofacial_bone0.86065463
136MP0003755_abnormal_palate_morphology0.85883869
137MP0000955_abnormal_spinal_cord0.85795852
138MP0003984_embryonic_growth_retardation0.85633993
139MP0003943_abnormal_hepatobiliary_system0.84865605
140MP0001672_abnormal_embryogenesis/_devel0.83402801
141MP0005380_embryogenesis_phenotype0.83402801
142MP0000266_abnormal_heart_morphology0.83073859
143MP0002081_perinatal_lethality0.82662216
144MP0004264_abnormal_extraembryonic_tissu0.82129304
145MP0010307_abnormal_tumor_latency0.81214497
146MP0005671_abnormal_response_to0.81202930
147MP0001346_abnormal_lacrimal_gland0.80836486
148MP0005310_abnormal_salivary_gland0.80692962
149MP0000462_abnormal_digestive_system0.80523408
150MP0004270_analgesia0.79128014
151MP0005551_abnormal_eye_electrophysiolog0.78291433
152MP0001879_abnormal_lymphatic_vessel0.78127464
153MP0001915_intracranial_hemorrhage0.77283845
154MP0005167_abnormal_blood-brain_barrier0.76736203
155MP0009115_abnormal_fat_cell0.76727024
156MP0002882_abnormal_neuron_morphology0.75684313
157MP0002877_abnormal_melanocyte_morpholog0.75494100
158MP0001730_embryonic_growth_arrest0.75232438
159MP0008569_lethality_at_weaning0.75082537
160MP0003191_abnormal_cellular_cholesterol0.73813210
161MP0006138_congestive_heart_failure0.70868112
162MP0000767_abnormal_smooth_muscle0.70649590

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.67978722
2Short 4th metacarpal (HP:0010044)3.67978722
3Hyperacusis (HP:0010780)3.53367899
4Eczematoid dermatitis (HP:0000976)3.44248865
5Macroorchidism (HP:0000053)3.41260960
6Shallow orbits (HP:0000586)3.12610408
7Abnormality of the 4th metacarpal (HP:0010012)3.05172441
8Cerebral aneurysm (HP:0004944)2.91900696
9Elfin facies (HP:0004428)2.83042490
10Renal duplication (HP:0000075)2.72928243
11Renovascular hypertension (HP:0100817)2.72153645
12Obstructive sleep apnea (HP:0002870)2.70004603
13Broad metatarsal (HP:0001783)2.63706956
14Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.63310217
15Spontaneous hematomas (HP:0007420)2.58265403
16Overriding aorta (HP:0002623)2.53579478
17Colitis (HP:0002583)2.47726427
18Insomnia (HP:0100785)2.47578325
19T lymphocytopenia (HP:0005403)2.45601778
20Heterotopia (HP:0002282)2.44440537
21Papilledema (HP:0001085)2.40831823
22Narrow palate (HP:0000189)2.35411938
23Pointed chin (HP:0000307)2.34874174
24Neoplasm of the heart (HP:0100544)2.33991250
25Subacute progressive viral hepatitis (HP:0006572)2.33244735
26Obsessive-compulsive behavior (HP:0000722)2.31315474
27Recurrent bacterial skin infections (HP:0005406)2.28365391
28Abnormality of the fingertips (HP:0001211)2.25919159
29Gingivitis (HP:0000230)2.24276608
30Bowel diverticulosis (HP:0005222)2.24018272
31Papillary thyroid carcinoma (HP:0002895)2.24006111
32Enlarged penis (HP:0000040)2.22703062
33Aortic aneurysm (HP:0004942)2.21951314
34Increased nuchal translucency (HP:0010880)2.20367255
35Trigonocephaly (HP:0000243)2.19057876
36Astrocytoma (HP:0009592)2.18113087
37Abnormality of the astrocytes (HP:0100707)2.18113087
38Flat cornea (HP:0007720)2.17772642
39Recurrent abscess formation (HP:0002722)2.15808966
40Syringomyelia (HP:0003396)2.14653561
41Spinal cord lesions (HP:0100561)2.14653561
42Abnormality of the diencephalon (HP:0010662)2.14587887
43Metaphyseal cupping (HP:0003021)2.14324413
44Cellulitis (HP:0100658)2.13570594
45Germ cell neoplasia (HP:0100728)2.12112974
46Mitral valve prolapse (HP:0001634)2.11227136
47Viral hepatitis (HP:0006562)2.07982343
48Dislocated radial head (HP:0003083)2.07970942
49Bladder diverticulum (HP:0000015)2.05948979
50Buphthalmos (HP:0000557)2.05848543
51Broad face (HP:0000283)2.05684747
52Volvulus (HP:0002580)2.05604472
53Pseudobulbar signs (HP:0002200)2.05301594
54Abnormality of T cell number (HP:0011839)2.04378749
55Lymphangioma (HP:0100764)2.00793036
56Deviation of the hallux (HP:0010051)1.99644095
57Ankyloglossia (HP:0010296)1.99511616
58Midline defect of the nose (HP:0004122)1.98102593
59Broad thumb (HP:0011304)1.97721254
60Recurrent gram-negative bacterial infections (HP:0005420)1.96432672
61Vertebral arch anomaly (HP:0008438)1.94919175
62Gastrointestinal infarctions (HP:0005244)1.93957540
63Hallux valgus (HP:0001822)1.93677489
64Neonatal hypoglycemia (HP:0001998)1.91973790
65Abnormality of the radial head (HP:0003995)1.91893375
66Long eyelashes (HP:0000527)1.89755475
67Gastrointestinal inflammation (HP:0004386)1.89039744
68Genetic anticipation (HP:0003743)1.88416608
69Aneurysm (HP:0002617)1.87611326
70Increased IgE level (HP:0003212)1.86421243
71Sacral dimple (HP:0000960)1.86419334
72Inflammation of the large intestine (HP:0002037)1.86103783
73Ankle contracture (HP:0006466)1.85473650
74Ulnar bowing (HP:0003031)1.85402167
75Abnormality of oral frenula (HP:0000190)1.85195347
76Abnormality of the lower motor neuron (HP:0002366)1.85175901
77Rectal prolapse (HP:0002035)1.85117576
78Abnormal delayed hypersensitivity skin test (HP:0002963)1.85041675
79Flat acetabular roof (HP:0003180)1.83647945
80Turricephaly (HP:0000262)1.82666032
81Action tremor (HP:0002345)1.82251208
82Arterial tortuosity (HP:0005116)1.82091996
83Ependymoma (HP:0002888)1.81944812
84Recurrent fungal infections (HP:0002841)1.81671466
85Aqueductal stenosis (HP:0002410)1.81363197
86Termporal pattern (HP:0011008)1.81194139
87Insidious onset (HP:0003587)1.81194139
88Recurrent viral infections (HP:0004429)1.79482061
89Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.79243754
90Dysmetric saccades (HP:0000641)1.77377787
91Truncal obesity (HP:0001956)1.76003658
92Overgrowth (HP:0001548)1.75904148
93Arnold-Chiari malformation (HP:0002308)1.75045215
94Fibrous tissue neoplasm (HP:0012316)1.74964284
95Hemiplegia (HP:0002301)1.74930622
96Meningitis (HP:0001287)1.74884091
97Slow saccadic eye movements (HP:0000514)1.73881006
98Dilatation of the ascending aorta (HP:0005111)1.72753647
99Panhypogammaglobulinemia (HP:0003139)1.72417067
100Acute myeloid leukemia (HP:0004808)1.71591588
101Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.71495307
102Myositis (HP:0100614)1.71180062
103Short phalanx of the thumb (HP:0009660)1.70759692
104Neoplasm of the oral cavity (HP:0100649)1.69875471
105Abnormality of incisor morphology (HP:0011063)1.69265230
106Fibroma (HP:0010614)1.69250590
107Bronchomalacia (HP:0002780)1.68520756
108Absent frontal sinuses (HP:0002688)1.67879226
109Transitional cell carcinoma of the bladder (HP:0006740)1.67384178
110Visceral angiomatosis (HP:0100761)1.66998533
111Malignant gastrointestinal tract tumors (HP:0006749)1.66827669
112Gastrointestinal carcinoma (HP:0002672)1.66827669
113Protrusio acetabuli (HP:0003179)1.66452925
114Recurrent bronchitis (HP:0002837)1.65217995
115Difficulty running (HP:0009046)1.62367366
116Asymmetry of the thorax (HP:0001555)1.61630353
117Thick eyebrow (HP:0000574)1.60682185
118Leiomyosarcoma (HP:0100243)1.60591476
119Uterine leiomyosarcoma (HP:0002891)1.60591476
120Recurrent cutaneous fungal infections (HP:0011370)1.60363995
121Chronic mucocutaneous candidiasis (HP:0002728)1.60363995
122Broad phalanges of the hand (HP:0009768)1.60268623
123Broad palm (HP:0001169)1.59855465
124Sandal gap (HP:0001852)1.59701157
125Broad finger (HP:0001500)1.59586536
126Glioma (HP:0009733)1.59406651
127Hemangiomatosis (HP:0007461)1.59221917
128Anteriorly placed anus (HP:0001545)1.58898663
129Deep philtrum (HP:0002002)1.57701983
130Exostoses (HP:0100777)1.57550038
131Upper limb amyotrophy (HP:0009129)1.57223947
132Distal upper limb amyotrophy (HP:0007149)1.57223947
133Supernumerary ribs (HP:0005815)1.56361063
134Vascular tortuosity (HP:0004948)1.55773815
135Abnormality of the peritoneum (HP:0002585)1.55745305
136Mediastinal lymphadenopathy (HP:0100721)1.55600448
137Disproportionate tall stature (HP:0001519)1.54955248
138Short 1st metacarpal (HP:0010034)1.54463162
139Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.54463162
140Smooth philtrum (HP:0000319)1.53686945
141Agammaglobulinemia (HP:0004432)1.52712859
142Persistence of primary teeth (HP:0006335)1.52645466
143Recurrent skin infections (HP:0001581)1.52503251
144Hematochezia (HP:0002573)1.52320307
145Increased density of long bones (HP:0006392)1.51869900
146Bladder carcinoma (HP:0002862)1.51685737
147Bladder neoplasm (HP:0009725)1.51685737
148Tracheomalacia (HP:0002779)1.51290328
149Scanning speech (HP:0002168)1.51006349
150Scapular winging (HP:0003691)1.50781237
151Hepatoblastoma (HP:0002884)1.50608132
152Onion bulb formation (HP:0003383)1.50338633
153Hypoplasia of the maxilla (HP:0000327)1.50257747
154Striae distensae (HP:0001065)1.50115267
155Long toe (HP:0010511)1.49857839
156Thin bony cortex (HP:0002753)1.49838603
157Abnormality of the left ventricular outflow tract (HP:0011103)1.49579274
158Subaortic stenosis (HP:0001682)1.49579274
159Broad phalanx (HP:0006009)1.49480658
160Abnormality of the distal phalanx of the thumb (HP:0009617)1.49284009
161Interstitial pulmonary disease (HP:0006530)1.47724505
162Abnormality of chromosome segregation (HP:0002916)1.47194590
163Lower limb asymmetry (HP:0100559)1.47070468
164Chest pain (HP:0100749)1.46729905
165Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.46113923
166Thickened helices (HP:0000391)1.45593073
167Abnormal vertebral ossification (HP:0100569)1.45517799
168Abnormality of the humeroradial joint (HP:0100744)1.45352127
169Deeply set eye (HP:0000490)1.44132701

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.26054838
2PKN22.93868537
3EEF2K2.91956459
4PRPF4B2.85551707
5MAP3K102.80469225
6CDK122.80462444
7CAMK1G2.46512088
8RIPK42.42478671
9RIPK12.26750559
10LATS12.21459034
11PDGFRA2.14418278
12CAMK1D2.06330604
13SIK21.97774766
14BRD41.96969157
15FGFR21.96103621
16PTK61.90565351
17ICK1.87433660
18SIK11.83711981
19TYRO31.80683183
20MAP4K11.71154539
21TTN1.67692202
22NTRK31.64385544
23BLK1.63902022
24MAP3K131.63857307
25ALK1.51548908
26DDR21.51473331
27MAP3K91.51433033
28SGK21.51305805
29TYK21.50916758
30NLK1.43699588
31FES1.42739129
32KSR21.39847547
33YES11.38142096
34RET1.37188062
35MTOR1.36430271
36SMG11.34810721
37PDGFRB1.29175372
38CSK1.27518404
39BTK1.23773340
40CDK61.19481932
41SCYL21.18448444
42PAK61.17914868
43DMPK1.16130995
44FGFR11.14701311
45PRKD31.14701017
46FGFR31.13666359
47MAP2K31.12563308
48MAP3K71.12129922
49SGK4941.11739759
50SGK2231.11739759
51KSR11.11316250
52PRKCH1.10707303
53ZAP701.08010951
54AKT31.07837619
55MAP3K141.07760523
56WNK11.05798291
57PNCK1.03344198
58MARK11.02019446
59HCK1.01738533
60BMX0.99036865
61MAP3K20.98087251
62CDC42BPA0.97730007
63CAMKK10.97679132
64JAK20.97106561
65MAP3K60.95898351
66STK380.95779979
67JAK30.95234494
68CSNK1A1L0.94464930
69NEK20.92461349
70NTRK20.91014355
71PAK20.90429143
72MARK20.89493549
73MAP3K40.88790674
74TAOK10.87515060
75ITK0.86632312
76SGK30.85918720
77ERBB20.84329578
78PTK20.81766741
79SYK0.81447285
80DAPK20.81098966
81TNK20.77882520
82LRRK20.77024038
83HIPK20.76929073
84FGFR40.76866585
85EPHB20.75476515
86FGR0.73734619
87EPHB10.73103819
88STK30.72108464
89NEK90.71461003
90MELK0.71341633
91MAPK70.70833479
92IKBKE0.70516863
93CDK90.69673388
94STK110.69237887
95MAPK120.68867564
96PRKD20.68572288
97PDK10.65748340
98LATS20.65001881
99NEK60.64965236
100MAPK150.64394298
101MAP3K10.64182129
102LCK0.63659333
103IRAK40.63205588
104EPHA40.62206226
105CSNK1G20.61902572
106GRK60.61671650
107PAK40.61504340
108PRKD10.61373502
109DYRK1B0.60628861
110CSNK1D0.60403227
111PAK30.58529776
112ERN10.56695845
113PASK0.56390216
114DYRK1A0.55066028
115RPS6KB20.54601354
116TEC0.53738702
117PDPK10.53105444
118RPS6KC10.52402660
119RPS6KL10.52402660
120CDK40.51714142
121FER0.51233651
122JAK10.50878818
123ERBB30.50227382
124UHMK10.49776423
125LMTK20.49763418
126TRPM70.49063335
127MAPK100.48176065
128TGFBR20.48161397
129MAPK80.48096531
130LYN0.47352462
131NTRK10.47351713
132RPS6KA20.46680496
133FYN0.45991429
134CSNK1E0.45350329
135EPHA30.44610299
136CDC70.44439967
137PRKDC0.44215978
138GSK3B0.43584156
139CAMK40.43234179
140CDK50.42358451
141RPS6KA30.42198025
142CSNK1G10.41808457
143SGK10.41773773
144SRC0.40382857
145PRKAA10.39440558
146MAPK140.38864759
147GSK3A0.38242591

Predicted pathways (KEGG)

RankGene SetZ-score
1Acute myeloid leukemia_Homo sapiens_hsa052211.74533462
2Nitrogen metabolism_Homo sapiens_hsa009101.66797389
3mTOR signaling pathway_Homo sapiens_hsa041501.59686424
4Chronic myeloid leukemia_Homo sapiens_hsa052201.51440392
5Dorso-ventral axis formation_Homo sapiens_hsa043201.49287800
6Lysine degradation_Homo sapiens_hsa003101.46983288
7Type II diabetes mellitus_Homo sapiens_hsa049301.45986481
8Basal cell carcinoma_Homo sapiens_hsa052171.43425495
9Osteoclast differentiation_Homo sapiens_hsa043801.42059157
10Glioma_Homo sapiens_hsa052141.40851470
11Endometrial cancer_Homo sapiens_hsa052131.40490706
12Thyroid hormone signaling pathway_Homo sapiens_hsa049191.37148284
13Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.36487181
14Proteoglycans in cancer_Homo sapiens_hsa052051.33859627
15Long-term potentiation_Homo sapiens_hsa047201.33837334
16Leishmaniasis_Homo sapiens_hsa051401.33761517
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.31723440
18Estrogen signaling pathway_Homo sapiens_hsa049151.30759586
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.25536622
20Colorectal cancer_Homo sapiens_hsa052101.24886216
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.22765865
22Non-small cell lung cancer_Homo sapiens_hsa052231.22733245
23Focal adhesion_Homo sapiens_hsa045101.21291950
24Adherens junction_Homo sapiens_hsa045201.21168381
25Circadian entrainment_Homo sapiens_hsa047131.20031008
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.19545809
27Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.18944634
28Neurotrophin signaling pathway_Homo sapiens_hsa047221.18928743
29Hippo signaling pathway_Homo sapiens_hsa043901.18642988
30Axon guidance_Homo sapiens_hsa043601.17348161
31Gastric acid secretion_Homo sapiens_hsa049711.14987678
32Notch signaling pathway_Homo sapiens_hsa043301.14247354
33MicroRNAs in cancer_Homo sapiens_hsa052061.13103356
34Phototransduction_Homo sapiens_hsa047441.11877688
35Hedgehog signaling pathway_Homo sapiens_hsa043401.10805157
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08312017
37Renal cell carcinoma_Homo sapiens_hsa052111.08171647
38Thyroid cancer_Homo sapiens_hsa052161.08106590
39Glutamatergic synapse_Homo sapiens_hsa047241.08054540
40Hepatitis B_Homo sapiens_hsa051611.07494220
41Renin secretion_Homo sapiens_hsa049241.06879450
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06834813
43Measles_Homo sapiens_hsa051621.05499007
44Melanogenesis_Homo sapiens_hsa049161.05294576
45ErbB signaling pathway_Homo sapiens_hsa040121.05021807
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.04999729
47GnRH signaling pathway_Homo sapiens_hsa049121.03974172
48Dopaminergic synapse_Homo sapiens_hsa047281.03856558
49Oxytocin signaling pathway_Homo sapiens_hsa049211.03567319
50Salivary secretion_Homo sapiens_hsa049701.03328985
51Olfactory transduction_Homo sapiens_hsa047401.03028549
52Longevity regulating pathway - mammal_Homo sapiens_hsa042111.02606840
53Central carbon metabolism in cancer_Homo sapiens_hsa052301.02308347
54Cholinergic synapse_Homo sapiens_hsa047251.02221414
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.02209110
56Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.02148470
57VEGF signaling pathway_Homo sapiens_hsa043701.01706662
58Toxoplasmosis_Homo sapiens_hsa051451.01366948
59Small cell lung cancer_Homo sapiens_hsa052221.00362521
60cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00338356
61Wnt signaling pathway_Homo sapiens_hsa043100.99868748
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.99795780
63Insulin resistance_Homo sapiens_hsa049310.99487781
64Chemokine signaling pathway_Homo sapiens_hsa040620.99483202
65Gap junction_Homo sapiens_hsa045400.99229573
66Insulin secretion_Homo sapiens_hsa049110.98740638
67Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.98490507
68Pancreatic cancer_Homo sapiens_hsa052120.98387904
69Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.97155308
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.96528856
71Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.96045801
72Jak-STAT signaling pathway_Homo sapiens_hsa046300.94609660
73Dilated cardiomyopathy_Homo sapiens_hsa054140.94354776
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94015779
75ECM-receptor interaction_Homo sapiens_hsa045120.93277315
76Influenza A_Homo sapiens_hsa051640.92801584
77GABAergic synapse_Homo sapiens_hsa047270.92744407
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92197507
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91475311
80Hepatitis C_Homo sapiens_hsa051600.91376734
81cAMP signaling pathway_Homo sapiens_hsa040240.90967856
82Amphetamine addiction_Homo sapiens_hsa050310.90428254
83Toll-like receptor signaling pathway_Homo sapiens_hsa046200.89522613
84Morphine addiction_Homo sapiens_hsa050320.88379889
85Rap1 signaling pathway_Homo sapiens_hsa040150.87917991
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.86588204
87Tuberculosis_Homo sapiens_hsa051520.86512393
88Insulin signaling pathway_Homo sapiens_hsa049100.86098241
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85609940
90B cell receptor signaling pathway_Homo sapiens_hsa046620.85531413
91Choline metabolism in cancer_Homo sapiens_hsa052310.85352548
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.85235534
93Cocaine addiction_Homo sapiens_hsa050300.85207196
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84618954
95Platelet activation_Homo sapiens_hsa046110.83762528
96AMPK signaling pathway_Homo sapiens_hsa041520.83333196
97Staphylococcus aureus infection_Homo sapiens_hsa051500.83281963
98Prostate cancer_Homo sapiens_hsa052150.82989535
99Long-term depression_Homo sapiens_hsa047300.79683230
100Thyroid hormone synthesis_Homo sapiens_hsa049180.79229687
101Primary immunodeficiency_Homo sapiens_hsa053400.79107446
102MAPK signaling pathway_Homo sapiens_hsa040100.78133419
103mRNA surveillance pathway_Homo sapiens_hsa030150.77939202
104Tight junction_Homo sapiens_hsa045300.76590414
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.75846786
106Glucagon signaling pathway_Homo sapiens_hsa049220.75621453
107Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.74800948
108Pathways in cancer_Homo sapiens_hsa052000.74449971
109Viral myocarditis_Homo sapiens_hsa054160.73790172
110TNF signaling pathway_Homo sapiens_hsa046680.73004725
111NF-kappa B signaling pathway_Homo sapiens_hsa040640.72150062
112HTLV-I infection_Homo sapiens_hsa051660.72012836
113Prolactin signaling pathway_Homo sapiens_hsa049170.71505863
114Amoebiasis_Homo sapiens_hsa051460.71220866
115FoxO signaling pathway_Homo sapiens_hsa040680.70595907
116Leukocyte transendothelial migration_Homo sapiens_hsa046700.70213454
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69848255
118Viral carcinogenesis_Homo sapiens_hsa052030.69301683
119Herpes simplex infection_Homo sapiens_hsa051680.69008122
120Bladder cancer_Homo sapiens_hsa052190.68058199
121Oocyte meiosis_Homo sapiens_hsa041140.67432913
122Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67151592
123T cell receptor signaling pathway_Homo sapiens_hsa046600.67129002
124Inositol phosphate metabolism_Homo sapiens_hsa005620.66979815
125HIF-1 signaling pathway_Homo sapiens_hsa040660.65562541
126Adipocytokine signaling pathway_Homo sapiens_hsa049200.65447718
127Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65175547
128NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64010126
129Apoptosis_Homo sapiens_hsa042100.63569222
130Ras signaling pathway_Homo sapiens_hsa040140.63564312
131Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.62832092
132Malaria_Homo sapiens_hsa051440.59473366
133Graft-versus-host disease_Homo sapiens_hsa053320.57410170
134Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56725164

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »