DDX18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it is activated by Myc protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)4.92320642
2formation of translation preinitiation complex (GO:0001731)4.57522731
3DNA unwinding involved in DNA replication (GO:0006268)4.56800949
4DNA replication initiation (GO:0006270)4.49209637
5DNA strand elongation involved in DNA replication (GO:0006271)4.46038276
6nucleobase biosynthetic process (GO:0046112)4.44524001
7ribosomal small subunit assembly (GO:0000028)4.31276907
8DNA strand elongation (GO:0022616)4.25143356
9viral transcription (GO:0019083)4.18303150
10protein localization to kinetochore (GO:0034501)4.16570817
11translational termination (GO:0006415)4.14037065
12mitotic metaphase plate congression (GO:0007080)4.13462317
13ribosome assembly (GO:0042255)4.10361165
14ribosome biogenesis (GO:0042254)4.07138593
15purine nucleobase biosynthetic process (GO:0009113)4.06546390
16ribosomal small subunit biogenesis (GO:0042274)4.06362015
17ribonucleoprotein complex biogenesis (GO:0022613)4.02002159
18nuclear pore organization (GO:0006999)4.00956179
19ribosomal large subunit biogenesis (GO:0042273)4.00392479
20telomere maintenance via semi-conservative replication (GO:0032201)4.00220714
21DNA replication checkpoint (GO:0000076)3.99857377
22folic acid-containing compound biosynthetic process (GO:0009396)3.98740471
23mitotic nuclear envelope disassembly (GO:0007077)3.94780655
24IMP biosynthetic process (GO:0006188)3.92911851
25mitotic sister chromatid cohesion (GO:0007064)3.89595465
26translational initiation (GO:0006413)3.85989785
27translational elongation (GO:0006414)3.77353641
28nuclear pore complex assembly (GO:0051292)3.75279540
29DNA ligation (GO:0006266)3.69784347
30DNA replication-dependent nucleosome assembly (GO:0006335)3.68851015
31DNA replication-dependent nucleosome organization (GO:0034723)3.68851015
32rRNA processing (GO:0006364)3.66868172
33regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.64639704
34regulation of mitotic spindle checkpoint (GO:1903504)3.64639704
35nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.63514847
36spliceosomal snRNP assembly (GO:0000387)3.62888730
37membrane disassembly (GO:0030397)3.62857774
38nuclear envelope disassembly (GO:0051081)3.62857774
39telomere maintenance via recombination (GO:0000722)3.62346468
40metaphase plate congression (GO:0051310)3.59278108
41sister chromatid segregation (GO:0000819)3.58579138
42rRNA metabolic process (GO:0016072)3.55862568
43protein localization to chromosome, centromeric region (GO:0071459)3.54123019
44mitotic recombination (GO:0006312)3.53744206
45double-strand break repair via nonhomologous end joining (GO:0006303)3.53455820
46non-recombinational repair (GO:0000726)3.53455820
47IMP metabolic process (GO:0046040)3.50395079
48chromatin remodeling at centromere (GO:0031055)3.47209247
49CENP-A containing nucleosome assembly (GO:0034080)3.44270969
50SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.43630724
51DNA deamination (GO:0045006)3.41597298
52regulation of centriole replication (GO:0046599)3.40859533
53regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.39688543
54establishment of viral latency (GO:0019043)3.39175646
55telomere maintenance via telomere lengthening (GO:0010833)3.39158234
56regulation of helicase activity (GO:0051095)3.38551013
57negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.35456461
58negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.35456461
59DNA double-strand break processing (GO:0000729)3.35103988
60cotranslational protein targeting to membrane (GO:0006613)3.34836348
61protein targeting to ER (GO:0045047)3.33712796
62mitochondrial RNA metabolic process (GO:0000959)3.29440466
63establishment of integrated proviral latency (GO:0075713)3.28745631
64negative regulation of DNA-dependent DNA replication (GO:2000104)3.27671606
65mitotic spindle checkpoint (GO:0071174)3.27174472
66termination of RNA polymerase II transcription (GO:0006369)3.26972577
67DNA replication-independent nucleosome assembly (GO:0006336)3.26741355
68DNA replication-independent nucleosome organization (GO:0034724)3.26741355
69cellular protein complex disassembly (GO:0043624)3.26729425
70kinetochore organization (GO:0051383)3.26389019
71mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.24390733
72pseudouridine synthesis (GO:0001522)3.23732267
73viral life cycle (GO:0019058)3.22302209
74regulation of spindle organization (GO:0090224)3.22278327
75transcription from mitochondrial promoter (GO:0006390)3.22167615
76establishment of chromosome localization (GO:0051303)3.19805520
77histone mRNA metabolic process (GO:0008334)3.19701786
78establishment of protein localization to mitochondrial membrane (GO:0090151)3.19492444
79regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.17475272
80regulation of mitotic metaphase/anaphase transition (GO:0030071)3.17475272
81establishment of protein localization to endoplasmic reticulum (GO:0072599)3.17283804
82rRNA methylation (GO:0031167)3.17033313
83DNA duplex unwinding (GO:0032508)3.16920677
84nucleotide-excision repair, DNA gap filling (GO:0006297)3.16817745
85spliceosomal complex assembly (GO:0000245)3.16679201
86DNA geometric change (GO:0032392)3.15948693
87exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.15777052
88regulation of DNA endoreduplication (GO:0032875)3.15101878
89DNA topological change (GO:0006265)3.14726810
90transcription-coupled nucleotide-excision repair (GO:0006283)3.13595989
91mitotic sister chromatid segregation (GO:0000070)3.13376585
92regulation of mitotic sister chromatid separation (GO:0010965)3.11570865
93regulation of mitotic sister chromatid segregation (GO:0033047)3.11570865
94regulation of sister chromatid segregation (GO:0033045)3.11570865
95protein localization to endoplasmic reticulum (GO:0070972)3.11146305
96mitotic spindle assembly checkpoint (GO:0007094)3.09347697
97regulation of chromosome segregation (GO:0051983)3.08620981
98mitotic chromosome condensation (GO:0007076)3.07264513
99rRNA modification (GO:0000154)3.06866053
100spindle assembly checkpoint (GO:0071173)3.05794998
101maturation of 5.8S rRNA (GO:0000460)3.05382827
102RNA splicing, via transesterification reactions (GO:0000375)3.05085908
103somatic diversification of immune receptors via somatic mutation (GO:0002566)3.03975306
104somatic hypermutation of immunoglobulin genes (GO:0016446)3.03975306
105nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.03756583
106RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.03606962
107mRNA splicing, via spliceosome (GO:0000398)3.03606962
108regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.02147390
109attachment of spindle microtubules to kinetochore (GO:0008608)3.01542055
110DNA-templated transcription, termination (GO:0006353)3.00989185
111nuclear-transcribed mRNA catabolic process (GO:0000956)3.00698543
112protein complex disassembly (GO:0043241)3.00570451
113somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.00246192
114isotype switching (GO:0045190)3.00246192
115somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.00246192
116pre-miRNA processing (GO:0031054)2.99309192
117translation (GO:0006412)2.99080917
118histone exchange (GO:0043486)2.98201898
119somatic recombination of immunoglobulin gene segments (GO:0016447)2.96303114
120termination of RNA polymerase I transcription (GO:0006363)2.96123564
121regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.95972129
122proteasome assembly (GO:0043248)2.95431957
123transcription elongation from RNA polymerase I promoter (GO:0006362)2.94296061
124positive regulation of chromosome segregation (GO:0051984)2.93903764
125kinetochore assembly (GO:0051382)2.92943986
126termination of RNA polymerase III transcription (GO:0006386)2.92510214
127transcription elongation from RNA polymerase III promoter (GO:0006385)2.92510214
128anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.91773043
129cellular component biogenesis (GO:0044085)2.91519496
130pore complex assembly (GO:0046931)2.89637711
131folic acid metabolic process (GO:0046655)2.88153821
132negative regulation of chromosome segregation (GO:0051985)2.88067148
133spindle checkpoint (GO:0031577)2.87877799
134RNA catabolic process (GO:0006401)2.87067211
135regulation of nuclear cell cycle DNA replication (GO:0033262)2.86576994
136mRNA catabolic process (GO:0006402)2.85948303
137macromolecular complex disassembly (GO:0032984)2.85092479
138negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.85042132
139negative regulation of mitotic sister chromatid separation (GO:2000816)2.84071382
140negative regulation of mitotic sister chromatid segregation (GO:0033048)2.84071382
141negative regulation of sister chromatid segregation (GO:0033046)2.84071382

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.41535699
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.58313344
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.71219172
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.66247698
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.57663976
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.28568887
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.06912742
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.06711885
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.04237952
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.97188847
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.90725219
12* ETS1_20019798_ChIP-Seq_JURKAT_Human2.88750438
13* GABP_17652178_ChIP-ChIP_JURKAT_Human2.84630953
14* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.77199193
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.59401822
16XRN2_22483619_ChIP-Seq_HELA_Human2.47677257
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.43683921
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.38973825
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.34199114
20* VDR_23849224_ChIP-Seq_CD4+_Human2.25166743
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.16087563
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.06661278
23AR_21909140_ChIP-Seq_LNCAP_Human2.05112096
24FOXP3_21729870_ChIP-Seq_TREG_Human2.01579171
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.00175754
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.99929894
27DCP1A_22483619_ChIP-Seq_HELA_Human1.98762457
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.97172942
29MYCN_18555785_ChIP-Seq_MESCs_Mouse1.94646719
30E2F1_21310950_ChIP-Seq_MCF-7_Human1.92250433
31TTF2_22483619_ChIP-Seq_HELA_Human1.91949051
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.89323439
33* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.85305747
34* GABP_19822575_ChIP-Seq_HepG2_Human1.85062493
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.83646889
36EGR1_19374776_ChIP-ChIP_THP-1_Human1.80224120
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.78503948
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.77958744
39SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.76331241
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.72542827
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69866378
42ELK1_19687146_ChIP-ChIP_HELA_Human1.64932176
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64903430
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.63533382
45CIITA_25753668_ChIP-Seq_RAJI_Human1.63057197
46* EWS_26573619_Chip-Seq_HEK293_Human1.60523991
47MYC_22102868_ChIP-Seq_BL_Human1.59086881
48ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54438270
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.53101941
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51229499
51KDM5A_27292631_Chip-Seq_BREAST_Human1.49739340
52FUS_26573619_Chip-Seq_HEK293_Human1.49101430
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.49090612
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.48766928
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.48683298
56POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.45118693
57SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.40177252
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.37578558
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.35168737
60* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34671424
61TP63_19390658_ChIP-ChIP_HaCaT_Human1.34131292
62STAT3_1855785_ChIP-Seq_MESCs_Mouse1.31899917
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28519407
64MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27796295
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.27108911
66FLI1_27457419_Chip-Seq_LIVER_Mouse1.25571410
67* SRF_21415370_ChIP-Seq_HL-1_Mouse1.25482051
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21341262
69KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21047750
70SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17105922
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16718691
72TFEB_21752829_ChIP-Seq_HELA_Human1.15980245
73KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.15879531
74ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14487739
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.13778978
76DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13134504
77E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11488200
78FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.10833978
79KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.09252131
80KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.09252131
81KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.09252131
82* NANOG_16153702_ChIP-ChIP_HESCs_Human1.07950171
83RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06904724
84MYC_18940864_ChIP-ChIP_HL60_Human1.04994555
85TCF3_18692474_ChIP-Seq_MEFs_Mouse1.03164460
86CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.02059034
87* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01985697
88CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00464191
89PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.99293221
90POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99232610
91CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98080881
92PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97938468
93KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96693461
94ELK1_22589737_ChIP-Seq_MCF10A_Human0.95692450
95* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.95639826
96BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95158065
97CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.94010606
98SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.93332836
99ZNF274_21170338_ChIP-Seq_K562_Hela0.93315641
100SOX17_20123909_ChIP-Seq_XEN_Mouse0.92743570
101TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.90425283
102SOX2_16153702_ChIP-ChIP_HESCs_Human0.90258649
103NANOG_21062744_ChIP-ChIP_HESCs_Human0.89971082
104VDR_21846776_ChIP-Seq_THP-1_Human0.89160664
105SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.89135290
106SALL1_21062744_ChIP-ChIP_HESCs_Human0.85748409
107POU3F2_20337985_ChIP-ChIP_501MEL_Human0.85439760
108GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83328217
109CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.82992711
110NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.81933512
111* PCGF2_27294783_Chip-Seq_ESCs_Mouse0.81561272
112SOX2_18692474_ChIP-Seq_MEFs_Mouse0.81070350
113* SPI1_23547873_ChIP-Seq_NB4_Human0.80865860
114* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.80585285
115NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.79681297
116VDR_22108803_ChIP-Seq_LS180_Human0.79674533
117* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.73579488
118ELF5_23300383_ChIP-Seq_T47D_Human0.73054715
119SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.72646570
120CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.69729385
121IGF1R_20145208_ChIP-Seq_DFB_Human0.68488140
122DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.68161346
123IRF1_19129219_ChIP-ChIP_H3396_Human0.64969117
124CHD1_26751641_Chip-Seq_LNCaP_Human0.64736069
125* TAF15_26573619_Chip-Seq_HEK293_Human0.64658532

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.62768207
2MP0004957_abnormal_blastocyst_morpholog4.63240485
3MP0010094_abnormal_chromosome_stability4.53854319
4MP0003111_abnormal_nucleus_morphology4.45893547
5MP0008057_abnormal_DNA_replication4.34328366
6MP0003077_abnormal_cell_cycle3.98218113
7MP0008058_abnormal_DNA_repair3.50593792
8MP0008007_abnormal_cellular_replicative2.97315629
9MP0009697_abnormal_copulation2.93508949
10MP0008932_abnormal_embryonic_tissue2.81755663
11MP0001730_embryonic_growth_arrest2.55558570
12MP0003123_paternal_imprinting2.55056658
13MP0000350_abnormal_cell_proliferation2.33035528
14MP0010352_gastrointestinal_tract_polyps2.29038640
15MP0002396_abnormal_hematopoietic_system2.15820282
16MP0003786_premature_aging2.07387346
17MP0001672_abnormal_embryogenesis/_devel1.89984705
18MP0005380_embryogenesis_phenotype1.89984705
19MP0008877_abnormal_DNA_methylation1.86488082
20MP0001697_abnormal_embryo_size1.85838809
21MP0010307_abnormal_tumor_latency1.80789597
22MP0003718_maternal_effect1.71146337
23MP0000490_abnormal_crypts_of1.70598200
24MP0003984_embryonic_growth_retardation1.69832144
25MP0002085_abnormal_embryonic_tissue1.68334712
26MP0002080_prenatal_lethality1.66901393
27MP0002088_abnormal_embryonic_growth/wei1.66265331
28MP0002084_abnormal_developmental_patter1.59416080
29MP0010030_abnormal_orbit_morphology1.54117970
30MP0004197_abnormal_fetal_growth/weight/1.48919231
31MP0000313_abnormal_cell_death1.46948021
32MP0002086_abnormal_extraembryonic_tissu1.46131498
33MP0003890_abnormal_embryonic-extraembry1.42489499
34MP0006035_abnormal_mitochondrial_morpho1.42241880
35MP0003806_abnormal_nucleotide_metabolis1.40803496
36MP0009333_abnormal_splenocyte_physiolog1.39851198
37MP0002019_abnormal_tumor_incidence1.37949247
38MP0001293_anophthalmia1.37836954
39MP0002009_preneoplasia1.37645411
40MP0004808_abnormal_hematopoietic_stem1.35944351
41MP0003567_abnormal_fetal_cardiomyocyte1.32052923
42MP0008995_early_reproductive_senescence1.24230174
43MP0003315_abnormal_perineum_morphology1.23038731
44MP0002210_abnormal_sex_determination1.22939486
45MP0003763_abnormal_thymus_physiology1.22656255
46MP0006072_abnormal_retinal_apoptosis1.20836507
47MP0003121_genomic_imprinting1.16728575
48MP0006292_abnormal_olfactory_placode1.15732957
49MP0005076_abnormal_cell_differentiation1.12796780
50MP0000703_abnormal_thymus_morphology1.11362322
51MP0001145_abnormal_male_reproductive1.09621424
52MP0003119_abnormal_digestive_system1.07670885
53MP0004133_heterotaxia1.06876274
54MP0000537_abnormal_urethra_morphology1.06150673
55MP0005397_hematopoietic_system_phenotyp1.02938796
56MP0001545_abnormal_hematopoietic_system1.02938796
57MP0002653_abnormal_ependyma_morphology0.99449616
58MP0001188_hyperpigmentation0.96150394
59MP0001929_abnormal_gametogenesis0.95393388
60MP0002398_abnormal_bone_marrow0.94745366
61MP0002722_abnormal_immune_system0.94600183
62MP0000653_abnormal_sex_gland0.92131602
63MP0003941_abnormal_skin_development0.91103263
64MP0004185_abnormal_adipocyte_glucose0.87750485
65MP0002111_abnormal_tail_morphology0.87746870
66MP0000689_abnormal_spleen_morphology0.87655219
67MP0009053_abnormal_anal_canal0.87535079
68MP0003937_abnormal_limbs/digits/tail_de0.87023661
69MP0000358_abnormal_cell_content/0.86918229
70MP0009672_abnormal_birth_weight0.85351685
71MP0000647_abnormal_sebaceous_gland0.80767479
72MP0006036_abnormal_mitochondrial_physio0.80636309
73MP0003943_abnormal_hepatobiliary_system0.79762746
74MP0005408_hypopigmentation0.79115785
75MP0003186_abnormal_redox_activity0.79063187
76MP0001286_abnormal_eye_development0.77976977
77MP0000858_altered_metastatic_potential0.77865382
78MP0005084_abnormal_gallbladder_morpholo0.77400379
79MP0005023_abnormal_wound_healing0.76698027
80MP0002233_abnormal_nose_morphology0.76494775
81MP0005384_cellular_phenotype0.76354947
82MP0002160_abnormal_reproductive_system0.75812976
83MP0002006_tumorigenesis0.75728661
84MP0000631_abnormal_neuroendocrine_gland0.75120311
85MP0000428_abnormal_craniofacial_morphol0.75053354
86MP0001119_abnormal_female_reproductive0.74585100
87MP0002429_abnormal_blood_cell0.73140487
88MP0009703_decreased_birth_body0.72917752
89MP0005395_other_phenotype0.72749315
90MP0005621_abnormal_cell_physiology0.70786547
91MP0005389_reproductive_system_phenotype0.69163917
92MP0002092_abnormal_eye_morphology0.69026035
93MP0001915_intracranial_hemorrhage0.64864669
94MP0001529_abnormal_vocalization0.63831012
95MP0005391_vision/eye_phenotype0.63744741
96MP0000432_abnormal_head_morphology0.63358637
97MP0000627_abnormal_mammary_gland0.63280416
98MP0003136_yellow_coat_color0.62617818
99MP0001849_ear_inflammation0.62593712
100MP0000477_abnormal_intestine_morphology0.61647881
101MP0003699_abnormal_female_reproductive0.61513947
102MP0001661_extended_life_span0.60553536
103MP0002938_white_spotting0.60441542
104MP0003566_abnormal_cell_adhesion0.60004866
105MP0002132_abnormal_respiratory_system0.59916772
106MP0002095_abnormal_skin_pigmentation0.59911476
107MP0009278_abnormal_bone_marrow0.59759869
108MP0001853_heart_inflammation0.59651722
109MP0006054_spinal_hemorrhage0.59081031
110MP0001346_abnormal_lacrimal_gland0.59065874
111MP0000716_abnormal_immune_system0.58732370
112MP0002163_abnormal_gland_morphology0.58587164
113MP0002102_abnormal_ear_morphology0.58256018
114MP0003221_abnormal_cardiomyocyte_apopto0.58068119
115MP0000579_abnormal_nail_morphology0.57563425
116MP0005075_abnormal_melanosome_morpholog0.57549064
117MP0008789_abnormal_olfactory_epithelium0.57529435
118MP0000569_abnormal_digit_pigmentation0.57209594
119MP0001764_abnormal_homeostasis0.56707045
120MP0000750_abnormal_muscle_regeneration0.55817663
121MP0003861_abnormal_nervous_system0.55580926
122MP0002697_abnormal_eye_size0.54414254
123MP0003755_abnormal_palate_morphology0.53887516
124MP0003698_abnormal_male_reproductive0.53760991
125MP0005187_abnormal_penis_morphology0.53503809
126MP0002114_abnormal_axial_skeleton0.52586076
127MP0003936_abnormal_reproductive_system0.51470276
128MP0005501_abnormal_skin_physiology0.51130646
129MP0001919_abnormal_reproductive_system0.50652768
130MP0009379_abnormal_foot_pigmentation0.49520775
131MP0003705_abnormal_hypodermis_morpholog0.49425173
132MP0008770_decreased_survivor_rate0.49356862
133MP0000049_abnormal_middle_ear0.49276764
134MP0003448_altered_tumor_morphology0.48581505

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.93343683
2Reticulocytopenia (HP:0001896)4.53870984
3Abnormality of cells of the erythroid lineage (HP:0012130)4.39054479
4Abnormal number of erythroid precursors (HP:0012131)4.05408050
5Breast hypoplasia (HP:0003187)3.82012966
6Colon cancer (HP:0003003)3.57945961
7Selective tooth agenesis (HP:0001592)3.49363691
8Chromsome breakage (HP:0040012)3.49084341
9Oral leukoplakia (HP:0002745)3.36089411
10Ependymoma (HP:0002888)3.35744531
11Abnormality of the anterior horn cell (HP:0006802)3.34389622
12Degeneration of anterior horn cells (HP:0002398)3.34389622
13Medulloblastoma (HP:0002885)3.32750886
14Chromosomal breakage induced by crosslinking agents (HP:0003221)3.32579899
15Carpal bone hypoplasia (HP:0001498)3.30497746
16Patellar aplasia (HP:0006443)3.28729512
17Increased hepatocellular lipid droplets (HP:0006565)3.20967168
18Macrocytic anemia (HP:0001972)3.17618589
19Aplasia/Hypoplasia of the patella (HP:0006498)3.10622617
20Nephroblastoma (Wilms tumor) (HP:0002667)3.07980360
21Volvulus (HP:0002580)3.04693327
22Rough bone trabeculation (HP:0100670)2.98404070
23Meckel diverticulum (HP:0002245)2.97758957
24Aplastic anemia (HP:0001915)2.95302234
25Embryonal renal neoplasm (HP:0011794)2.94798710
26Absent radius (HP:0003974)2.94124893
27Cerebral hypomyelination (HP:0006808)2.93342393
28Abnormality of chromosome stability (HP:0003220)2.93257338
29Abnormality of the preputium (HP:0100587)2.89177011
30Pallor (HP:0000980)2.88191573
31Absent thumb (HP:0009777)2.87133812
32Abnormality of the ileum (HP:0001549)2.86432218
33Lipid accumulation in hepatocytes (HP:0006561)2.79728101
34Absent forearm bone (HP:0003953)2.73695424
35Aplasia involving forearm bones (HP:0009822)2.73695424
36Agnosia (HP:0010524)2.73480818
37Abnormality of methionine metabolism (HP:0010901)2.72538073
38Microvesicular hepatic steatosis (HP:0001414)2.71433185
39Abnormal number of incisors (HP:0011064)2.71027851
40Aplasia/Hypoplasia of the uvula (HP:0010293)2.65170388
41Rhabdomyosarcoma (HP:0002859)2.63698766
4211 pairs of ribs (HP:0000878)2.57859422
43Impulsivity (HP:0100710)2.57550989
44Abnormality of the labia minora (HP:0012880)2.56035422
45Supernumerary spleens (HP:0009799)2.55861604
46Myelodysplasia (HP:0002863)2.55835635
47Trismus (HP:0000211)2.55774773
48Neoplasm of the pancreas (HP:0002894)2.52102636
49Premature graying of hair (HP:0002216)2.50816628
50Homocystinuria (HP:0002156)2.50362813
51Abnormality of homocysteine metabolism (HP:0010919)2.50362813
52Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.45562539
53Abnormality of alanine metabolism (HP:0010916)2.45562539
54Hyperalaninemia (HP:0003348)2.45562539
55Basal cell carcinoma (HP:0002671)2.45061491
56Progressive external ophthalmoplegia (HP:0000590)2.36240262
57Duodenal stenosis (HP:0100867)2.32975941
58Small intestinal stenosis (HP:0012848)2.32975941
59Acute necrotizing encephalopathy (HP:0006965)2.32267809
60Horseshoe kidney (HP:0000085)2.31779491
61Microretrognathia (HP:0000308)2.31672081
62Premature ovarian failure (HP:0008209)2.31247690
63Bone marrow hypocellularity (HP:0005528)2.30857473
64Glossoptosis (HP:0000162)2.30323316
65Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.29930336
66Megaloblastic anemia (HP:0001889)2.28830150
67Multiple enchondromatosis (HP:0005701)2.26397309
68Proximal placement of thumb (HP:0009623)2.25878425
69Atresia of the external auditory canal (HP:0000413)2.25457715
70Abnormality of the pons (HP:0007361)2.24780425
71Increased CSF lactate (HP:0002490)2.21817784
72Acute encephalopathy (HP:0006846)2.21315049
73Cellular immunodeficiency (HP:0005374)2.21035127
74Clubbing of toes (HP:0100760)2.20681054
75Deviation of the thumb (HP:0009603)2.19393074
76Aplasia/Hypoplasia of the sacrum (HP:0008517)2.18290778
77Sloping forehead (HP:0000340)2.18215531
78Increased serum lactate (HP:0002151)2.17705864
79Tracheoesophageal fistula (HP:0002575)2.16527710
80Hypoplasia of the pons (HP:0012110)2.16332645
81Neoplasm of the colon (HP:0100273)2.16240830
82Triphalangeal thumb (HP:0001199)2.15642155
83Abnormal trabecular bone morphology (HP:0100671)2.14549166
84Squamous cell carcinoma (HP:0002860)2.13829897
85Abnormality of aspartate family amino acid metabolism (HP:0010899)2.13534183
86Abnormality of serum amino acid levels (HP:0003112)2.13165817
87Secondary amenorrhea (HP:0000869)2.12968696
88Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.10953775
89Missing ribs (HP:0000921)2.09054526
90Abnormal lung lobation (HP:0002101)2.05133986
91Neoplasm of striated muscle (HP:0009728)2.03761255
92Mitochondrial inheritance (HP:0001427)2.02938118
93Amaurosis fugax (HP:0100576)2.02576888
94Ectopic kidney (HP:0000086)2.02413515
95Duplicated collecting system (HP:0000081)2.02193633
96Thrombocytosis (HP:0001894)2.02053622
97Progressive muscle weakness (HP:0003323)2.01369116
98Irregular epiphyses (HP:0010582)2.00874853
99Abnormality of the duodenum (HP:0002246)2.00785612
100Sensory axonal neuropathy (HP:0003390)1.99207715
101Abnormal mitochondria in muscle tissue (HP:0008316)1.98239150
102Increased nuchal translucency (HP:0010880)1.98025869
103Abnormality of the astrocytes (HP:0100707)1.96898060
104Astrocytoma (HP:0009592)1.96898060
105Cleft eyelid (HP:0000625)1.96702713
106Abdominal situs inversus (HP:0003363)1.93338509
107Abnormality of abdominal situs (HP:0011620)1.93338509
108Short thumb (HP:0009778)1.92934305
109Abnormality of the septum pellucidum (HP:0007375)1.91961289
110Aplasia/Hypoplasia of the sternum (HP:0006714)1.90991533
111Overlapping toe (HP:0001845)1.90926370
112Neoplasm of the oral cavity (HP:0100649)1.90742782
113Cerebral edema (HP:0002181)1.90346339
114Glioma (HP:0009733)1.89894669
115Atrophy/Degeneration involving motor neurons (HP:0007373)1.89189227
116Progressive macrocephaly (HP:0004481)1.88174566
117Hypoplasia of the radius (HP:0002984)1.88092061
118Aplasia/hypoplasia of the humerus (HP:0006507)1.87685952
119Lymphoma (HP:0002665)1.85337447
120Stenosis of the external auditory canal (HP:0000402)1.84407580
121Septo-optic dysplasia (HP:0100842)1.83491653
122Spinal muscular atrophy (HP:0007269)1.82751162
123Bilateral microphthalmos (HP:0007633)1.82718605
124Asplenia (HP:0001746)1.82620280
125Facial hemangioma (HP:0000329)1.82315045
126Acute myeloid leukemia (HP:0004808)1.81464062
127Prominent nose (HP:0000448)1.80591778
128Methylmalonic acidemia (HP:0002912)1.79028533
129Abnormality of DNA repair (HP:0003254)1.78415230
1303-Methylglutaconic aciduria (HP:0003535)1.78302801
131Hypoplasia of the capital femoral epiphysis (HP:0003090)1.78040298
132Pancytopenia (HP:0001876)1.77652357
133Cafe-au-lait spot (HP:0000957)1.76718522
134CNS hypomyelination (HP:0003429)1.76248238
135Abnormality of reticulocytes (HP:0004312)1.75732391
136Slender long bone (HP:0003100)1.75334426
137Abnormality of the carotid arteries (HP:0005344)1.74165481
138Abnormality of the renal collecting system (HP:0004742)1.73976828
139Leukodystrophy (HP:0002415)1.73036159
140Choanal atresia (HP:0000453)1.70385687
141Increased serum pyruvate (HP:0003542)1.70333421
142Combined immunodeficiency (HP:0005387)1.69617384
143Facial cleft (HP:0002006)1.66264408
144Congenital, generalized hypertrichosis (HP:0004540)1.66202308
145Pancreatic islet-cell hyperplasia (HP:0004510)1.66055022
146IgM deficiency (HP:0002850)1.65964319
147Abnormality of sulfur amino acid metabolism (HP:0004339)1.64735117
148Type I transferrin isoform profile (HP:0003642)1.63860717
149Renal Fanconi syndrome (HP:0001994)1.63427658
150Hepatocellular necrosis (HP:0001404)1.63319443
151Arteriovenous malformation (HP:0100026)1.62411367
152Neoplasm of the adrenal cortex (HP:0100641)1.61577404

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.57232121
2WEE14.34032394
3CDC74.12167604
4EIF2AK13.08800271
5TSSK62.90325092
6VRK22.88456461
7SRPK12.72058113
8NME22.57835120
9NEK22.55064227
10TTK2.31147147
11TAF12.26378909
12NUAK12.03515979
13BRSK22.02879111
14CDK122.01266953
15TESK22.00049404
16PASK1.98097619
17MKNK11.96346041
18EIF2AK31.94652678
19PLK11.94586850
20PLK41.89298663
21CDK71.82685903
22STK161.81331052
23ACVR1B1.79747996
24VRK11.77696232
25TLK11.75246890
26AURKB1.70747294
27ATR1.70172931
28RPS6KB21.70097955
29NEK11.70073589
30PLK31.64403258
31DYRK31.62715390
32MKNK21.56871622
33RPS6KA41.52229781
34EPHA21.51367137
35MAP3K81.49229199
36STK101.41760996
37EEF2K1.39324953
38CDK41.38423226
39CHEK21.37783456
40CHEK11.33487422
41LATS11.27936587
42AURKA1.26166202
43TNIK1.25148324
44TGFBR11.14808222
45PNCK1.14607896
46BRSK11.10014122
47SCYL21.10007174
48PAK41.07096444
49BRD40.99455721
50ERBB40.94643525
51TRIM280.93979159
52ATM0.93264931
53CDK20.92351118
54STK40.89870206
55PIM10.88798605
56ALK0.87963647
57CSNK2A20.85193102
58MAP4K10.85135428
59BMPR1B0.85098404
60WNK30.82012663
61BCR0.80581294
62CCNB10.79509356
63LRRK20.76727240
64FLT30.73301200
65MELK0.72192896
66PAK10.71129636
67PIM20.70905136
68MAP3K100.70600097
69CSNK2A10.70525335
70ERBB30.68696432
71CDK10.64023399
72KDR0.62441644
73MAP3K110.62123215
74MST40.61548168
75STK240.60208443
76MAP3K120.59898553
77CDK60.59538356
78LATS20.57120419
79EIF2AK20.56715315
80TESK10.56261109
81STK30.56097329
82ZAK0.55387638
83CSNK1E0.53673126
84RPS6KA50.53404107
85PRKCI0.53144401
86SMG10.51233807
87WNK40.50811971
88CAMK1G0.50180789
89CDK80.50036445
90STK390.49286122
91MAPKAPK50.49238111
92CDK30.48522564
93STK38L0.47563692
94TAOK20.47049487
95MAPKAPK30.46583363
96MAP2K30.45852250
97TEC0.45714894
98CAMK1D0.45690507
99PBK0.45484713
100CDK90.45044028
101FRK0.44314340
102BRAF0.44156869
103NME10.42304008
104PKN20.41772479
105OXSR10.41716183
106CSNK1G10.40000504
107* MTOR0.38894686
108PAK20.37899922
109BTK0.35983311
110PRKDC0.35735538
111AKT20.35239912
112ZAP700.33888121
113ILK0.33578032
114MAP3K140.32223722
115GRK60.30609855
116DYRK20.30499009
117YES10.28676584
118NEK60.27759237
119FGFR10.26624828
120MAPK140.25485815
121CSNK1D0.24760595
122CLK10.22657159
123RAF10.22469489
124CSNK1A1L0.21870443
125MARK30.21444726
126MST1R0.20826729
127GSK3B0.20761667
128JAK30.20429133
129NLK0.19735498
130AKT10.19373277
131IKBKB0.18762916

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.66053566
2Mismatch repair_Homo sapiens_hsa034304.05058321
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.02735419
4Ribosome_Homo sapiens_hsa030103.82393103
5RNA polymerase_Homo sapiens_hsa030203.67589915
6Spliceosome_Homo sapiens_hsa030403.52139913
7RNA transport_Homo sapiens_hsa030133.36056972
8Proteasome_Homo sapiens_hsa030503.22017751
9Homologous recombination_Homo sapiens_hsa034402.91318184
10Base excision repair_Homo sapiens_hsa034102.87907628
11Nucleotide excision repair_Homo sapiens_hsa034202.86420173
12One carbon pool by folate_Homo sapiens_hsa006702.74422654
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.62272515
14Cell cycle_Homo sapiens_hsa041102.61046334
15Pyrimidine metabolism_Homo sapiens_hsa002402.50239796
16Fanconi anemia pathway_Homo sapiens_hsa034602.24337985
17Non-homologous end-joining_Homo sapiens_hsa034502.11058373
18RNA degradation_Homo sapiens_hsa030182.03124723
19Basal transcription factors_Homo sapiens_hsa030222.00943669
20mRNA surveillance pathway_Homo sapiens_hsa030151.84733840
21Oxidative phosphorylation_Homo sapiens_hsa001901.74415909
22p53 signaling pathway_Homo sapiens_hsa041151.54732505
23Purine metabolism_Homo sapiens_hsa002301.34515162
24Epstein-Barr virus infection_Homo sapiens_hsa051691.27084780
25Propanoate metabolism_Homo sapiens_hsa006401.15948362
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15444613
27Antigen processing and presentation_Homo sapiens_hsa046121.02658348
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00300407
29Systemic lupus erythematosus_Homo sapiens_hsa053220.97003248
30Pyruvate metabolism_Homo sapiens_hsa006200.96812279
31Cysteine and methionine metabolism_Homo sapiens_hsa002700.94393285
32Viral carcinogenesis_Homo sapiens_hsa052030.91058738
33Herpes simplex infection_Homo sapiens_hsa051680.91037155
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.89749580
35Alzheimers disease_Homo sapiens_hsa050100.87559125
36Biosynthesis of amino acids_Homo sapiens_hsa012300.83380487
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.83299420
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83056932
39Folate biosynthesis_Homo sapiens_hsa007900.82981906
40Vitamin B6 metabolism_Homo sapiens_hsa007500.82693341
41Oocyte meiosis_Homo sapiens_hsa041140.79406862
42Selenocompound metabolism_Homo sapiens_hsa004500.79248104
43Cyanoamino acid metabolism_Homo sapiens_hsa004600.79066827
44Steroid biosynthesis_Homo sapiens_hsa001000.77042532
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76005717
46Pentose phosphate pathway_Homo sapiens_hsa000300.75294971
47HTLV-I infection_Homo sapiens_hsa051660.72320811
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72283026
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71474789
50Protein export_Homo sapiens_hsa030600.71058290
51Thyroid cancer_Homo sapiens_hsa052160.64433012
52Sulfur relay system_Homo sapiens_hsa041220.64206595
53Drug metabolism - other enzymes_Homo sapiens_hsa009830.63275017
54MicroRNAs in cancer_Homo sapiens_hsa052060.59693108
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58065870
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53072239
57Legionellosis_Homo sapiens_hsa051340.52541516
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52038144
59Vitamin digestion and absorption_Homo sapiens_hsa049770.50698949
60Primary immunodeficiency_Homo sapiens_hsa053400.49567196
61Small cell lung cancer_Homo sapiens_hsa052220.49563759
62Lysine degradation_Homo sapiens_hsa003100.48404415
63Glutathione metabolism_Homo sapiens_hsa004800.47374710
64TGF-beta signaling pathway_Homo sapiens_hsa043500.46793363
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46653959
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46277807
67Huntingtons disease_Homo sapiens_hsa050160.45851973
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44298006
69Hippo signaling pathway_Homo sapiens_hsa043900.41292094
70Basal cell carcinoma_Homo sapiens_hsa052170.40470649
71Notch signaling pathway_Homo sapiens_hsa043300.40130527
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39592454
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38201836
74Apoptosis_Homo sapiens_hsa042100.37816029
75NF-kappa B signaling pathway_Homo sapiens_hsa040640.37668251
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.35590942
77Carbon metabolism_Homo sapiens_hsa012000.34876556
78Measles_Homo sapiens_hsa051620.34740631
79Sulfur metabolism_Homo sapiens_hsa009200.34277064
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33765429
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32757251
82Fructose and mannose metabolism_Homo sapiens_hsa000510.31519042
83Colorectal cancer_Homo sapiens_hsa052100.28081463
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27427960
85Shigellosis_Homo sapiens_hsa051310.27064748
86NOD-like receptor signaling pathway_Homo sapiens_hsa046210.26707403
87Bladder cancer_Homo sapiens_hsa052190.26281342
88HIF-1 signaling pathway_Homo sapiens_hsa040660.26093259
89Cardiac muscle contraction_Homo sapiens_hsa042600.25689788
90Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.25520856
91Hedgehog signaling pathway_Homo sapiens_hsa043400.25489193
92N-Glycan biosynthesis_Homo sapiens_hsa005100.25259872
93Hepatitis B_Homo sapiens_hsa051610.24973779
94Alcoholism_Homo sapiens_hsa050340.21918478
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.21318766
96Pathways in cancer_Homo sapiens_hsa052000.20871229
97Hematopoietic cell lineage_Homo sapiens_hsa046400.20263873
98Fatty acid elongation_Homo sapiens_hsa000620.19992711
99Phototransduction_Homo sapiens_hsa047440.19904081
100Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.19766349
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.19553391
102Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18727181
103Chronic myeloid leukemia_Homo sapiens_hsa052200.18470402
104Acute myeloid leukemia_Homo sapiens_hsa052210.17659290
105Metabolic pathways_Homo sapiens_hsa011000.17357674
1062-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.16954778
107Parkinsons disease_Homo sapiens_hsa050120.16726715
108Nitrogen metabolism_Homo sapiens_hsa009100.15845194
109Influenza A_Homo sapiens_hsa051640.14838520
110Galactose metabolism_Homo sapiens_hsa000520.14743918
111Adherens junction_Homo sapiens_hsa045200.14730075
112Allograft rejection_Homo sapiens_hsa053300.14471227
113Butanoate metabolism_Homo sapiens_hsa006500.14409644
114Prostate cancer_Homo sapiens_hsa052150.13569510
115Viral myocarditis_Homo sapiens_hsa054160.12255035
116mTOR signaling pathway_Homo sapiens_hsa041500.11956819
117Arachidonic acid metabolism_Homo sapiens_hsa005900.11577429
118Asthma_Homo sapiens_hsa053100.10743009
119Graft-versus-host disease_Homo sapiens_hsa053320.09675472
120Retinol metabolism_Homo sapiens_hsa008300.09636230
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.08849067
122Arginine and proline metabolism_Homo sapiens_hsa003300.08408119
123Wnt signaling pathway_Homo sapiens_hsa043100.07491754
124Intestinal immune network for IgA production_Homo sapiens_hsa046720.07377356
125Olfactory transduction_Homo sapiens_hsa047400.05506128
126Peroxisome_Homo sapiens_hsa041460.03938334
127Tryptophan metabolism_Homo sapiens_hsa003800.03674522
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.03315100

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