DDX18P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thrombin receptor signaling pathway (GO:0070493)6.71626423
2neutrophil activation involved in immune response (GO:0002283)5.05396235
3interkinetic nuclear migration (GO:0022027)4.35871273
4protein neddylation (GO:0045116)4.35669731
5monoubiquitinated protein deubiquitination (GO:0035520)4.16298558
6regulation of platelet activation (GO:0010543)4.11804142
7regulation of platelet aggregation (GO:0090330)4.05850148
8negative regulation of thymocyte apoptotic process (GO:0070244)4.01739652
9positive regulation of granulocyte differentiation (GO:0030854)3.85903707
10positive regulation of mast cell activation (GO:0033005)3.85636087
11G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.80663118
12hepatocyte apoptotic process (GO:0097284)3.71963470
13leukocyte migration involved in inflammatory response (GO:0002523)3.69234271
14megakaryocyte development (GO:0035855)3.64606117
15blood coagulation, intrinsic pathway (GO:0007597)3.54225930
16cell wall macromolecule catabolic process (GO:0016998)3.53601060
17platelet aggregation (GO:0070527)3.53416248
18regulation of B cell receptor signaling pathway (GO:0050855)3.51136705
19definitive hemopoiesis (GO:0060216)3.47593354
20regulation of regulatory T cell differentiation (GO:0045589)3.44355287
21neutrophil activation (GO:0042119)3.43383278
22negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.41071980
23negative regulation of T-helper cell differentiation (GO:0045623)3.41071980
24negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.36223646
25negative regulation of norepinephrine secretion (GO:0010700)3.34180135
26regulation of integrin-mediated signaling pathway (GO:2001044)3.31291691
27phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.29496538
28regulation of integrin activation (GO:0033623)3.29379886
29positive regulation of natural killer cell mediated immunity (GO:0002717)3.29277270
30purinergic nucleotide receptor signaling pathway (GO:0035590)3.26220179
31regulation of pigment cell differentiation (GO:0050932)3.25476399
32positive regulation of endothelial cell differentiation (GO:0045603)3.23094000
33embryonic hemopoiesis (GO:0035162)3.15509054
34negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.15135774
35regulation of mast cell activation (GO:0033003)3.13032951
36phagocytosis, engulfment (GO:0006911)3.10711562
37negative regulation of T cell apoptotic process (GO:0070233)3.10484158
38regulation of memory T cell differentiation (GO:0043380)3.09199489
39angiogenesis involved in wound healing (GO:0060055)3.08999913
40positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.08333588
41cellular response to ethanol (GO:0071361)3.06766795
42positive regulation of gamma-delta T cell activation (GO:0046645)3.06518323
43positive regulation of alpha-beta T cell proliferation (GO:0046641)3.03857362
44negative regulation of neurotransmitter transport (GO:0051589)3.02689639
45B cell receptor signaling pathway (GO:0050853)3.01182614
46negative regulation of protein localization to cell surface (GO:2000009)3.00816104
47Arp2/3 complex-mediated actin nucleation (GO:0034314)2.96939133
48granulocyte activation (GO:0036230)2.92725967
49regulation of lipoprotein metabolic process (GO:0050746)2.90958845
50histone mRNA catabolic process (GO:0071044)2.88566403
51pericardium development (GO:0060039)2.88476831
52cell wall macromolecule metabolic process (GO:0044036)2.86164166
53epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.84188088
54myelin assembly (GO:0032288)2.78256096
55positive regulation of developmental pigmentation (GO:0048087)2.77701824
56negative regulation of heart rate (GO:0010459)2.76107402
57phospholipid homeostasis (GO:0055091)2.73531959
58platelet formation (GO:0030220)2.72338122
59tyrosine phosphorylation of STAT protein (GO:0007260)2.71766097
60regulation of mast cell activation involved in immune response (GO:0033006)2.71201547
61platelet activation (GO:0030168)2.70807935
62regulation of cilium movement (GO:0003352)2.67486426
63negative regulation of calcium ion transport into cytosol (GO:0010523)2.67430063
64adenosine receptor signaling pathway (GO:0001973)2.67292535
65cellular extravasation (GO:0045123)2.66783044
66mesodermal cell differentiation (GO:0048333)2.65346212
67maternal behavior (GO:0042711)2.65234885
68regulation of norepinephrine secretion (GO:0014061)2.64488820
69cilium or flagellum-dependent cell motility (GO:0001539)2.62680326
70regulation of erythrocyte differentiation (GO:0045646)2.62053997
71microtubule depolymerization (GO:0007019)2.60776570
72regulation of natural killer cell mediated immunity (GO:0002715)2.59667747
73regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.59667747
74negative regulation of heart contraction (GO:0045822)2.58382566
75positive regulation of T cell cytokine production (GO:0002726)2.58014623
76cytoplasmic mRNA processing body assembly (GO:0033962)2.56713031
77positive regulation of hemostasis (GO:1900048)2.56200783
78positive regulation of blood coagulation (GO:0030194)2.56200783
79actin nucleation (GO:0045010)2.55885805
80regulation of homotypic cell-cell adhesion (GO:0034110)2.54549579
81regulation of MHC class II biosynthetic process (GO:0045346)2.52719785
82homotypic cell-cell adhesion (GO:0034109)2.52704562
83negative regulation of platelet activation (GO:0010544)2.52446835
84parental behavior (GO:0060746)2.52001187
85natural killer cell activation involved in immune response (GO:0002323)2.51977911
86negative regulation of neurotransmitter secretion (GO:0046929)2.50586476
87negative regulation of homotypic cell-cell adhesion (GO:0034111)2.49441688
88regulation of Golgi to plasma membrane protein transport (GO:0042996)2.49420825
89positive regulation of macrophage differentiation (GO:0045651)2.49122344
90regulation of T-helper 1 cell differentiation (GO:0045625)2.46370194
91necrotic cell death (GO:0070265)2.46220788
92regulation of alpha-beta T cell proliferation (GO:0046640)2.45913926
93regulation of histone H3-K9 methylation (GO:0051570)2.45863269
94myeloid cell activation involved in immune response (GO:0002275)2.44994092
95positive regulation of B cell mediated immunity (GO:0002714)2.44924846
96positive regulation of immunoglobulin mediated immune response (GO:0002891)2.44924846
97antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.44878250
98positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.41025319
99positive regulation of cAMP-mediated signaling (GO:0043950)2.40819332
100positive regulation of B cell differentiation (GO:0045579)2.40801553

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.46858509
2GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.09526905
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.85949904
4GATA1_22025678_ChIP-Seq_K562_Human2.67165338
5SMAD_19615063_ChIP-ChIP_OVARY_Human2.53607924
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.45924134
7GBX2_23144817_ChIP-Seq_PC3_Human2.42795068
8SCL_19346495_ChIP-Seq_HPC-7_Human2.34859274
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.29712564
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.28344952
11SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.24216694
12TAF15_26573619_Chip-Seq_HEK293_Human2.14229615
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.06174130
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.00630801
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.96511809
16GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.90255692
17AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.85554013
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.84144568
19MYB_21317192_ChIP-Seq_ERMYB_Mouse1.81563400
20IRF8_21731497_ChIP-ChIP_J774_Mouse1.81514622
21EWS_26573619_Chip-Seq_HEK293_Human1.76732836
22SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.73223488
23TP53_16413492_ChIP-PET_HCT116_Human1.72190054
24IGF1R_20145208_ChIP-Seq_DFB_Human1.68852069
25VDR_22108803_ChIP-Seq_LS180_Human1.67396272
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.65605183
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.64727501
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.64562351
29RUNX_20019798_ChIP-Seq_JUKART_Human1.62105179
30IRF8_27001747_Chip-Seq_BMDM_Mouse1.59071345
31LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.57408217
32SMAD4_21799915_ChIP-Seq_A2780_Human1.57296900
33OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53306149
34GATA2_19941826_ChIP-Seq_K562_Human1.52617084
35GATA1_19941826_ChIP-Seq_K562_Human1.51804122
36FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.49207465
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.49179022
38ER_23166858_ChIP-Seq_MCF-7_Human1.48736093
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47864273
40MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47522611
41ESR1_20079471_ChIP-ChIP_T-47D_Human1.47222962
42EZH2_27294783_Chip-Seq_NPCs_Mouse1.44458380
43P300_19829295_ChIP-Seq_ESCs_Human1.44220786
44SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.43930354
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.43835307
46STAT3_23295773_ChIP-Seq_U87_Human1.43823930
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41757546
48PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.39251894
49NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37787251
50SPI1_23127762_ChIP-Seq_K562_Human1.36773118
51IRF8_22096565_ChIP-ChIP_GC-B_Human1.36490797
52MYB_26560356_Chip-Seq_TH2_Human1.35523858
53RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.35044783
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34656992
55GATA2_21666600_ChIP-Seq_HMVEC_Human1.31630607
56HTT_18923047_ChIP-ChIP_STHdh_Human1.31623800
57TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28764965
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28254497
59FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.28069052
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.28026690
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27010066
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25985628
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23518272
64POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23518272
65NFE2_27457419_Chip-Seq_LIVER_Mouse1.23081839
66AR_21572438_ChIP-Seq_LNCaP_Human1.22939660
67FOXM1_26456572_ChIP-Seq_MCF-7_Human1.21898631
68FLI1_21867929_ChIP-Seq_TH2_Mouse1.21779733
69GATA3_27048872_Chip-Seq_THYMUS_Human1.21749274
70EGR1_19374776_ChIP-ChIP_THP-1_Human1.21374205
71CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21197748
72VDR_24787735_ChIP-Seq_THP-1_Human1.21135681
73PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21130407
74ELK4_26923725_Chip-Seq_MESODERM_Mouse1.19895784
75TCF4_23295773_ChIP-Seq_U87_Human1.18558375
76GATA3_26560356_Chip-Seq_TH2_Human1.17897005
77GATA1_19941827_ChIP-Seq_MEL_Mouse1.16676663
78PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16559064
79CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.16151430
80BCAT_22108803_ChIP-Seq_LS180_Human1.14029286
81ARNT_22903824_ChIP-Seq_MCF-7_Human1.13878431
82PRDM14_20953172_ChIP-Seq_ESCs_Human1.13438359
83AR_25329375_ChIP-Seq_VCAP_Human1.12111689
84NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11848069
85NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11848069
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11027512
87NANOG_18555785_Chip-Seq_ESCs_Mouse1.10656063
88TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09137906
89WT1_19549856_ChIP-ChIP_CCG9911_Human1.07892996
90E2F1_18555785_Chip-Seq_ESCs_Mouse1.07490878
91SALL4_22934838_ChIP-ChIP_CD34+_Human1.06779431
92FUS_26573619_Chip-Seq_HEK293_Human1.06398515
93NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06353189
94P53_22387025_ChIP-Seq_ESCs_Mouse1.06233001
95OCT4_21477851_ChIP-Seq_ESCs_Mouse1.05899846
96ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05567809
97CRX_20693478_ChIP-Seq_RETINA_Mouse1.05514793
98SALL1_21062744_ChIP-ChIP_HESCs_Human1.03115331
99SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02244192
100TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01293112

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology6.83253052
2MP0000569_abnormal_digit_pigmentation5.27512568
3MP0008004_abnormal_stomach_pH3.31964121
4MP0003724_increased_susceptibility_to3.13929776
5MP0004084_abnormal_cardiac_muscle3.12976737
6MP0008057_abnormal_DNA_replication2.77226308
7MP0001835_abnormal_antigen_presentation2.61995027
8MP0000465_gastrointestinal_hemorrhage2.56163534
9MP0003828_pulmonary_edema2.30626905
10MP0005083_abnormal_biliary_tract2.03665694
11MP0006054_spinal_hemorrhage2.03072380
12MP0005671_abnormal_response_to1.98708123
13MP0008775_abnormal_heart_ventricle1.98591477
14MP0003303_peritoneal_inflammation1.96756757
15MP0005174_abnormal_tail_pigmentation1.95150815
16MP0003890_abnormal_embryonic-extraembry1.85839277
17MP0002398_abnormal_bone_marrow1.77184879
18MP0004036_abnormal_muscle_relaxation1.75592580
19MP0003763_abnormal_thymus_physiology1.74717144
20MP0004510_myositis1.73156412
21MP0009697_abnormal_copulation1.70782464
22MP0003950_abnormal_plasma_membrane1.67814229
23MP0005000_abnormal_immune_tolerance1.58797898
24MP0001800_abnormal_humoral_immune1.56914271
25MP0001851_eye_inflammation1.52256512
26MP0002837_dystrophic_cardiac_calcinosis1.48002189
27MP0008961_abnormal_basal_metabolism1.47210510
28MP0003787_abnormal_imprinting1.47045963
29MP0003656_abnormal_erythrocyte_physiolo1.43524396
30MP0000689_abnormal_spleen_morphology1.42515121
31MP0003045_fibrosis1.39915111
32MP0000015_abnormal_ear_pigmentation1.38518743
33MP0004130_abnormal_muscle_cell1.36238608
34MP0000249_abnormal_blood_vessel1.36099456
35MP0002653_abnormal_ependyma_morphology1.35754211
36MP0000230_abnormal_systemic_arterial1.35284088
37MP0002723_abnormal_immune_serum1.34485591
38MP0002148_abnormal_hypersensitivity_rea1.33751025
39MP0003566_abnormal_cell_adhesion1.31928397
40MP0002009_preneoplasia1.26015808
41MP0002420_abnormal_adaptive_immunity1.25831573
42MP0002452_abnormal_antigen_presenting1.23922030
43MP0001879_abnormal_lymphatic_vessel1.23586394
44MP0002722_abnormal_immune_system1.22498822
45MP0001819_abnormal_immune_cell1.20599397
46MP0005310_abnormal_salivary_gland1.20015133
47MP0000703_abnormal_thymus_morphology1.19277400
48MP0002166_altered_tumor_susceptibility1.18743756
49MP0000383_abnormal_hair_follicle1.17339799
50MP0000716_abnormal_immune_system1.14541132
51MP0004883_abnormal_blood_vessel1.14334979
52MP0005387_immune_system_phenotype1.13866383
53MP0001790_abnormal_immune_system1.13866383
54MP0010352_gastrointestinal_tract_polyps1.13735277
55MP0004134_abnormal_chest_morphology1.12714746
56MP0010155_abnormal_intestine_physiology1.11670833
57MP0005187_abnormal_penis_morphology1.11344915
58MP0004484_altered_response_of1.09673150
59MP0006138_congestive_heart_failure1.09298880
60MP0002429_abnormal_blood_cell1.08764706
61MP0009764_decreased_sensitivity_to1.08095083
62MP0002736_abnormal_nociception_after1.05673716
63MP0003943_abnormal_hepatobiliary_system1.05096982
64MP0005084_abnormal_gallbladder_morpholo1.04384746
65MP0003448_altered_tumor_morphology1.02460437
66MP0002405_respiratory_system_inflammati1.02333349
67MP0004808_abnormal_hematopoietic_stem1.00184296
68MP0005167_abnormal_blood-brain_barrier0.96709813
69MP0009763_increased_sensitivity_to0.93604578
70MP0002419_abnormal_innate_immunity0.92117203
71MP0003436_decreased_susceptibility_to0.90058674
72MP0001663_abnormal_digestive_system0.87770773
73MP0005025_abnormal_response_to0.85975081
74MP0003866_abnormal_defecation0.85195346
75MP0000343_altered_response_to0.85133643
76MP0002396_abnormal_hematopoietic_system0.83938216
77MP0004947_skin_inflammation0.83417163
78MP0002168_other_aberrant_phenotype0.78570829
79MP0004215_abnormal_myocardial_fiber0.78090774
80MP0001845_abnormal_inflammatory_respons0.77383381
81MP0000858_altered_metastatic_potential0.76922434
82MP0002128_abnormal_blood_circulation0.75293511
83MP0008872_abnormal_physiological_respon0.73524327
84MP0003183_abnormal_peptide_metabolism0.73223628
85MP0001915_intracranial_hemorrhage0.72522332
86MP0002998_abnormal_bone_remodeling0.72102885
87MP0001784_abnormal_fluid_regulation0.71588648
88MP0001191_abnormal_skin_condition0.71547439
89MP0004381_abnormal_hair_follicle0.68993398
90MP0000685_abnormal_immune_system0.66987401
91MP0010307_abnormal_tumor_latency0.66839631
92MP0010368_abnormal_lymphatic_system0.62478202
93MP0003638_abnormal_response/metabolism_0.62156250
94MP0005385_cardiovascular_system_phenoty0.62119281
95MP0001544_abnormal_cardiovascular_syste0.62119281
96MP0003091_abnormal_cell_migration0.61898687
97MP0003868_abnormal_feces_composition0.61828165
98MP0010678_abnormal_skin_adnexa0.61261661
99MP0005409_darkened_coat_color0.60908947
100MP0002972_abnormal_cardiac_muscle0.60828870

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)8.04705452
2Increased mean platelet volume (HP:0011877)7.32821947
3Menorrhagia (HP:0000132)7.22077710
4Abnormal platelet volume (HP:0011876)6.87581546
5Petechiae (HP:0000967)6.10027361
6Epistaxis (HP:0000421)5.83847932
7Gingival bleeding (HP:0000225)5.59425145
8Purpura (HP:0000979)5.30145742
9Hyperlipoproteinemia (HP:0010980)5.21165199
10Spontaneous hematomas (HP:0007420)4.39054275
11Papillary thyroid carcinoma (HP:0002895)4.26299155
12Abnormal platelet function (HP:0011869)4.08462097
13Impaired platelet aggregation (HP:0003540)4.08462097
14Dynein arm defect of respiratory motile cilia (HP:0012255)3.98487115
15Absent/shortened dynein arms (HP:0200106)3.98487115
16Poikilocytosis (HP:0004447)3.58028133
17Acanthocytosis (HP:0001927)3.47737711
18Volvulus (HP:0002580)3.41934160
19Conjunctival telangiectasia (HP:0000524)3.39232879
20Fair hair (HP:0002286)3.35553469
21Autoimmune hemolytic anemia (HP:0001890)3.31048771
22Dyschromatopsia (HP:0007641)3.20109673
23T lymphocytopenia (HP:0005403)3.05047440
24Hypoproteinemia (HP:0003075)2.94503396
25Abnormal hair whorl (HP:0010721)2.92032613
26Abnormality of the vasculature of the conjunctiva (HP:0008054)2.91347811
27Acute lymphatic leukemia (HP:0006721)2.86249147
28Abnormal ciliary motility (HP:0012262)2.79103339
29Abnormality of T cell number (HP:0011839)2.72298355
30Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.55909174
31Septate vagina (HP:0001153)2.55481660
32Rectovaginal fistula (HP:0000143)2.54224113
33Rectal fistula (HP:0100590)2.54224113
34Generalized hypopigmentation of hair (HP:0011358)2.54178619
35Portal hypertension (HP:0001409)2.53978327
36Bruising susceptibility (HP:0000978)2.52421814
37Abnormality of the common coagulation pathway (HP:0010990)2.51686308
38Thyroid carcinoma (HP:0002890)2.51572507
39Abnormality of the heme biosynthetic pathway (HP:0010472)2.42396910
40Intestinal fistula (HP:0100819)2.41350864
41B lymphocytopenia (HP:0010976)2.39554483
42Abnormality of B cell number (HP:0010975)2.31828265
43Abnormal respiratory motile cilium morphology (HP:0005938)2.31272158
44Abnormal respiratory epithelium morphology (HP:0012253)2.31272158
45Renal cortical cysts (HP:0000803)2.29838999
46Abnormality of the hepatic vasculature (HP:0006707)2.26157802
47Chest pain (HP:0100749)2.14250966
48IgA deficiency (HP:0002720)2.14230442
49Encephalitis (HP:0002383)2.09854467
50Truncal obesity (HP:0001956)2.05802311
51Facial diplegia (HP:0001349)2.03609150
52Chronic hepatic failure (HP:0100626)2.03092530
53Abnormal respiratory motile cilium physiology (HP:0012261)1.95751343
54Constricted visual fields (HP:0001133)1.92958794
55Abnormality of the fingertips (HP:0001211)1.92325984
56Febrile seizures (HP:0002373)1.91611184
57Recurrent abscess formation (HP:0002722)1.87866939
58Tubulointerstitial nephritis (HP:0001970)1.85490474
59Widely spaced teeth (HP:0000687)1.84317024
60Increased density of long bones (HP:0006392)1.83332215
61Recurrent bronchitis (HP:0002837)1.81163449
62Progressive cerebellar ataxia (HP:0002073)1.79982437
63Vaginal fistula (HP:0004320)1.79595082
64Abnormal auditory evoked potentials (HP:0006958)1.77413728
65Amaurosis fugax (HP:0100576)1.75232612
66Increased IgM level (HP:0003496)1.74504459
67Spontaneous abortion (HP:0005268)1.74099683
68Arterial thrombosis (HP:0004420)1.71636777
69Thyroiditis (HP:0100646)1.71123150
70Myocardial infarction (HP:0001658)1.70890490
71Submucous cleft hard palate (HP:0000176)1.70184907
72Tinnitus (HP:0000360)1.69663065
73Hypoplastic nipples (HP:0002557)1.68494990
74Abnormality of the renal cortex (HP:0011035)1.66039216
75Abnormality of T cells (HP:0002843)1.65959599
76Horizontal nystagmus (HP:0000666)1.63002598
77IgM deficiency (HP:0002850)1.62894814
78Protruding tongue (HP:0010808)1.62618112
79Absent frontal sinuses (HP:0002688)1.62364820
80Hypochromic microcytic anemia (HP:0004840)1.62241228
81Joint swelling (HP:0001386)1.61696216
82Recurrent fungal infections (HP:0002841)1.61249917
83Panhypogammaglobulinemia (HP:0003139)1.61186878
84Eosinophilia (HP:0001880)1.60745498
85Clumsiness (HP:0002312)1.60316257
86Skull defect (HP:0001362)1.59812427
87Abnormality of the prostate (HP:0008775)1.59027087
88Gaze-evoked nystagmus (HP:0000640)1.58803903
89Recurrent viral infections (HP:0004429)1.57888063
90Hyperventilation (HP:0002883)1.56987067
91Rhinitis (HP:0012384)1.53038096
92Acute myeloid leukemia (HP:0004808)1.51709468
93Cutis marmorata (HP:0000965)1.51541024
94Transitional cell carcinoma of the bladder (HP:0006740)1.51281011
95IgG deficiency (HP:0004315)1.51053031
96Genetic anticipation (HP:0003743)1.47233705
97Intestinal atresia (HP:0011100)1.46872063
98Abnormal pupillary function (HP:0007686)1.46749313
99Deep philtrum (HP:0002002)1.46659375
100Clitoromegaly (HP:0000057)1.46402337

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.97652005
2TEC3.38136924
3FRK3.01014489
4TAOK32.50726344
5NEK12.46624656
6ACVR1B2.44982429
7BTK2.42535700
8MST42.40457247
9CAMK1G2.12649147
10PIK3CG2.10272394
11PNCK1.86155509
12EIF2AK11.84147508
13SYK1.81826567
14BRSK21.74828779
15CAMKK21.72156311
16TXK1.71327904
17ITK1.68795579
18STK31.67187770
19MAP4K21.65731831
20AKT31.63314930
21ZAP701.63050471
22PTK2B1.62934281
23BMX1.59512168
24BLK1.58921983
25PIK3CA1.57999501
26NLK1.53938774
27IRAK11.53006704
28EPHA31.45489441
29CAMK1D1.39471737
30BMPR21.39360754
31SGK21.36348665
32HCK1.29161770
33MAPK131.28502200
34ADRBK21.28352998
35MYLK1.26467030
36CSF1R1.25253843
37PKN11.18570133
38GRK61.18278015
39YES11.18217070
40FES1.12890933
41PLK21.09556490
42TLK11.08338886
43TNIK1.08077867
44ERBB21.03402973
45CSK1.00055255
46NEK90.97867878
47NUAK10.97359220
48TRPM70.95844817
49IRAK20.92730984
50PLK40.91810682
51PDK10.90768668
52MAP3K50.88904930
53JAK10.86840790
54GRK50.86681883
55IKBKB0.86534009
56STK100.85987069
57PAK30.85549565
58JAK20.84673474
59PDGFRB0.80970192
60MELK0.80245275
61CAMK10.79026672
62PKN20.78882131
63LYN0.78247890
64ADRBK10.76689374
65MARK30.75227796
66STK240.75199279
67SGK30.73029739
68FLT30.69449145
69BRD40.68636396
70LCK0.64825601
71LATS10.62644958
72RET0.62013845
73MKNK20.61332517
74PIM10.59861103
75TYK20.57785782
76WNK10.57457798
77IKBKE0.57456510
78FER0.55281983
79STK160.53564998
80FGFR30.52959559
81BMPR1B0.52346226
82STK40.51813935
83FGR0.50172526
84MAPK110.49525107
85MAP2K30.49156964
86ZAK0.49038511
87SGK2230.48236276
88SGK4940.48236276
89PRKCQ0.46685467
90KSR10.43990282
91MAP3K10.43448694
92CAMK40.40351568
93PAK10.38632975
94MAP3K20.37753663
95PDPK10.36953703
96MAP4K10.36623759
97CDK80.36522121
98IGF1R0.34041058
99GRK10.32393351
100NEK20.32082356

Predicted pathways (KEGG)

RankGene SetZ-score
1Platelet activation_Homo sapiens_hsa046113.96984608
2Hematopoietic cell lineage_Homo sapiens_hsa046402.02933973
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.76775360
4Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.75497893
5T cell receptor signaling pathway_Homo sapiens_hsa046601.71113514
6SNARE interactions in vesicular transport_Homo sapiens_hsa041301.70093921
7B cell receptor signaling pathway_Homo sapiens_hsa046621.69457745
8Systemic lupus erythematosus_Homo sapiens_hsa053221.65968711
9Primary immunodeficiency_Homo sapiens_hsa053401.60057169
10Nitrogen metabolism_Homo sapiens_hsa009101.58424388
11Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.53120550
12Non-small cell lung cancer_Homo sapiens_hsa052231.52928340
13Alcoholism_Homo sapiens_hsa050341.40042456
14Chemokine signaling pathway_Homo sapiens_hsa040621.36506275
15Pancreatic cancer_Homo sapiens_hsa052121.31927603
16Measles_Homo sapiens_hsa051621.30719073
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.26672128
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.26149508
19ECM-receptor interaction_Homo sapiens_hsa045121.25349091
20Phosphatidylinositol signaling system_Homo sapiens_hsa040701.24985919
21Vascular smooth muscle contraction_Homo sapiens_hsa042701.21332465
22Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.20384429
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.18039902
24Osteoclast differentiation_Homo sapiens_hsa043801.17888008
25Regulation of actin cytoskeleton_Homo sapiens_hsa048101.17620909
26Choline metabolism in cancer_Homo sapiens_hsa052311.12906370
27Long-term depression_Homo sapiens_hsa047301.09548581
28Viral carcinogenesis_Homo sapiens_hsa052031.09216871
29Dorso-ventral axis formation_Homo sapiens_hsa043201.07076032
30Transcriptional misregulation in cancer_Homo sapiens_hsa052021.06988445
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.02528359
32Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.99934939
33Endometrial cancer_Homo sapiens_hsa052130.98528183
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.97821762
35Leukocyte transendothelial migration_Homo sapiens_hsa046700.97488226
36NF-kappa B signaling pathway_Homo sapiens_hsa040640.96517810
37Chronic myeloid leukemia_Homo sapiens_hsa052200.96402071
38Gap junction_Homo sapiens_hsa045400.95885945
39Phospholipase D signaling pathway_Homo sapiens_hsa040720.93372467
40Malaria_Homo sapiens_hsa051440.91012253
41Adherens junction_Homo sapiens_hsa045200.90966787
42Serotonergic synapse_Homo sapiens_hsa047260.89673919
43Glioma_Homo sapiens_hsa052140.89520006
44Graft-versus-host disease_Homo sapiens_hsa053320.89373395
45Acute myeloid leukemia_Homo sapiens_hsa052210.85301467
46FoxO signaling pathway_Homo sapiens_hsa040680.83959173
47Arachidonic acid metabolism_Homo sapiens_hsa005900.83941872
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83570801
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81545036
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80614397
51Autoimmune thyroid disease_Homo sapiens_hsa053200.79676391
52Shigellosis_Homo sapiens_hsa051310.79468508
53Endocytosis_Homo sapiens_hsa041440.77815318
54Pancreatic secretion_Homo sapiens_hsa049720.77683213
55Small cell lung cancer_Homo sapiens_hsa052220.77287469
56Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75687829
57Focal adhesion_Homo sapiens_hsa045100.74212451
58Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.72626077
59TNF signaling pathway_Homo sapiens_hsa046680.71788899
60Prostate cancer_Homo sapiens_hsa052150.71300024
61Melanoma_Homo sapiens_hsa052180.71169021
62Allograft rejection_Homo sapiens_hsa053300.71107607
63ABC transporters_Homo sapiens_hsa020100.70914416
64Glycerolipid metabolism_Homo sapiens_hsa005610.70574463
65Renal cell carcinoma_Homo sapiens_hsa052110.70471186
66Linoleic acid metabolism_Homo sapiens_hsa005910.69111267
67Mismatch repair_Homo sapiens_hsa034300.69061262
68Hepatitis B_Homo sapiens_hsa051610.68664621
69Notch signaling pathway_Homo sapiens_hsa043300.68530869
70Inositol phosphate metabolism_Homo sapiens_hsa005620.66968541
71Leishmaniasis_Homo sapiens_hsa051400.66706095
72Colorectal cancer_Homo sapiens_hsa052100.65398291
73TGF-beta signaling pathway_Homo sapiens_hsa043500.63808278
74Rap1 signaling pathway_Homo sapiens_hsa040150.63512007
75Prolactin signaling pathway_Homo sapiens_hsa049170.63045915
76Staphylococcus aureus infection_Homo sapiens_hsa051500.61912527
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.60827781
78Calcium signaling pathway_Homo sapiens_hsa040200.60028451
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59631729
80Amoebiasis_Homo sapiens_hsa051460.59153068
81Olfactory transduction_Homo sapiens_hsa047400.59072388
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.58619441
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58055525
84MicroRNAs in cancer_Homo sapiens_hsa052060.56855660
85Apoptosis_Homo sapiens_hsa042100.56633695
86Ras signaling pathway_Homo sapiens_hsa040140.55430481
87Cell cycle_Homo sapiens_hsa041100.55068520
88MAPK signaling pathway_Homo sapiens_hsa040100.55058677
89ErbB signaling pathway_Homo sapiens_hsa040120.54154709
90Oxytocin signaling pathway_Homo sapiens_hsa049210.54143353
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.53777670
92Tuberculosis_Homo sapiens_hsa051520.53300870
93Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52370075
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.50609509
95Influenza A_Homo sapiens_hsa051640.50205332
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49766086
97Long-term potentiation_Homo sapiens_hsa047200.48680348
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46522218
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45852841
100Intestinal immune network for IgA production_Homo sapiens_hsa046720.45332194

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