DDX18P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1monoubiquitinated protein deubiquitination (GO:0035520)8.47803810
2protein K48-linked deubiquitination (GO:0071108)5.19832177
3determination of adult lifespan (GO:0008340)4.86533812
4nuclear pore complex assembly (GO:0051292)4.81463868
5positive regulation of growth hormone secretion (GO:0060124)4.32454709
6regulation of growth hormone secretion (GO:0060123)4.30743757
7histone-serine phosphorylation (GO:0035404)4.21905251
8regulation of mitotic spindle checkpoint (GO:1903504)4.19047116
9regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.19047116
10nuclear pore organization (GO:0006999)4.13150506
11protein localization to kinetochore (GO:0034501)3.97241730
12negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.86611245
13negative regulation of translation, ncRNA-mediated (GO:0040033)3.86611245
14regulation of translation, ncRNA-mediated (GO:0045974)3.86611245
15positive regulation of mRNA catabolic process (GO:0061014)3.80489994
16sister chromatid segregation (GO:0000819)3.73325215
17regulation of mRNA catabolic process (GO:0061013)3.73038671
18chromatin remodeling at centromere (GO:0031055)3.69623765
19V(D)J recombination (GO:0033151)3.69049608
20protein localization to chromosome, centromeric region (GO:0071459)3.68981648
21RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.67092487
22negative regulation of DNA repair (GO:0045738)3.65281530
23CENP-A containing nucleosome assembly (GO:0034080)3.64402562
24prenylation (GO:0097354)3.63898865
25protein prenylation (GO:0018342)3.63898865
26mitotic sister chromatid cohesion (GO:0007064)3.58610918
27positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)3.57462267
28kinetochore organization (GO:0051383)3.53948813
29response to UV-C (GO:0010225)3.53845899
30natural killer cell differentiation (GO:0001779)3.53387681
31regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.52068148
32positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.52068148
33L-serine transport (GO:0015825)3.50305182
34cytoplasmic mRNA processing body assembly (GO:0033962)3.47091105
35DNA topological change (GO:0006265)3.45250123
36regulation of RNA export from nucleus (GO:0046831)3.44821735
37protein K6-linked ubiquitination (GO:0085020)3.43208889
38pore complex assembly (GO:0046931)3.41551985
39kinetochore assembly (GO:0051382)3.32473065
40negative regulation of DNA-dependent DNA replication (GO:2000104)3.31329760
41regulation of RIG-I signaling pathway (GO:0039535)3.27600111
42growth hormone secretion (GO:0030252)3.26211986
43positive regulation of cell cycle checkpoint (GO:1901978)3.25521859
44regulation of mRNA 3-end processing (GO:0031440)3.21136664
45negative regulation of chromosome segregation (GO:0051985)3.20386580
46pre-miRNA processing (GO:0031054)3.16482213
47regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.16476541
48positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.14162953
49regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.14162953
50embryonic process involved in female pregnancy (GO:0060136)3.11837241
51positive regulation of mRNA metabolic process (GO:1903313)3.11798042
52microtubule anchoring (GO:0034453)3.11450065
53negative regulation of mitotic sister chromatid separation (GO:2000816)3.11296974
54negative regulation of sister chromatid segregation (GO:0033046)3.11296974
55negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.11296974
56negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.11296974
57negative regulation of mitotic sister chromatid segregation (GO:0033048)3.11296974
58DNA replication-dependent nucleosome assembly (GO:0006335)3.10928155
59DNA replication-dependent nucleosome organization (GO:0034723)3.10928155
60histone mRNA catabolic process (GO:0071044)3.09395861
61regulation of sister chromatid segregation (GO:0033045)3.05834575
62regulation of mitotic sister chromatid separation (GO:0010965)3.05834575
63regulation of mitotic sister chromatid segregation (GO:0033047)3.05834575
64peptidyl-lysine trimethylation (GO:0018023)3.03880932
65spindle checkpoint (GO:0031577)3.03583904
66regulation of DNA endoreduplication (GO:0032875)3.02771844
67somatic diversification of immune receptors via somatic mutation (GO:0002566)3.01209687
68somatic hypermutation of immunoglobulin genes (GO:0016446)3.01209687
69regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.01109235
70regulation of mitotic metaphase/anaphase transition (GO:0030071)3.01109235
71histone exchange (GO:0043486)3.00996630
72mitotic spindle checkpoint (GO:0071174)2.98286982
73protein K63-linked deubiquitination (GO:0070536)2.97607686
74mitotic G2/M transition checkpoint (GO:0044818)2.97114144
75DNA demethylation (GO:0080111)2.96689047
76mitotic sister chromatid segregation (GO:0000070)2.96549860
77positive regulation of mRNA 3-end processing (GO:0031442)2.96538349
78regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.96146078
79DNA dealkylation (GO:0035510)2.95272083
80regulation of histone H3-K9 methylation (GO:0051570)2.94974300
81response to X-ray (GO:0010165)2.94770329
82peptidyl-lysine dimethylation (GO:0018027)2.93878619
83protein localization to chromosome (GO:0034502)2.93504418
84replication fork processing (GO:0031297)2.93080890
85regulation of spindle checkpoint (GO:0090231)2.92124268
86attachment of spindle microtubules to kinetochore (GO:0008608)2.87927902
87regulation of establishment of cell polarity (GO:2000114)2.87808263
88histone deubiquitination (GO:0016578)2.87467137
89pyrimidine nucleotide catabolic process (GO:0006244)2.86962431
90DNA replication-independent nucleosome organization (GO:0034724)2.85652300
91DNA replication-independent nucleosome assembly (GO:0006336)2.85652300
92negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.85559289
93somatic diversification of immune receptors (GO:0002200)2.85336155
94positive regulation of mRNA processing (GO:0050685)2.85097674
95mitotic spindle assembly checkpoint (GO:0007094)2.84876061
96cellular response to ethanol (GO:0071361)2.84807241
97positive regulation of developmental pigmentation (GO:0048087)2.83080193
98positive regulation of granulocyte differentiation (GO:0030854)2.82760866
99replicative senescence (GO:0090399)2.82611684
100exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.82601693

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.61799881
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.04816149
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.99109083
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.99741690
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.86805404
6VDR_22108803_ChIP-Seq_LS180_Human2.69578583
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.53213812
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.51727137
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.51547540
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.50948498
11FUS_26573619_Chip-Seq_HEK293_Human2.45940197
12TAF15_26573619_Chip-Seq_HEK293_Human2.44364229
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.38238868
14EWS_26573619_Chip-Seq_HEK293_Human2.29310300
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.16533428
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.07056273
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.05412765
18TP63_19390658_ChIP-ChIP_HaCaT_Human1.90165548
19P300_19829295_ChIP-Seq_ESCs_Human1.87135996
20KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.85679212
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.76743603
22SMAD3_21741376_ChIP-Seq_EPCs_Human1.76217112
23EZH2_27294783_Chip-Seq_NPCs_Mouse1.75757875
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.72852302
25AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.71348981
26E2F1_21310950_ChIP-Seq_MCF-7_Human1.71294136
27GBX2_23144817_ChIP-Seq_PC3_Human1.71158421
28POU5F1_16153702_ChIP-ChIP_HESCs_Human1.69661413
29STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.58667644
30SUZ12_27294783_Chip-Seq_NPCs_Mouse1.56611543
31CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.54433882
32CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.53981395
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52322559
34NFE2_27457419_Chip-Seq_LIVER_Mouse1.49776519
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47096054
36ER_23166858_ChIP-Seq_MCF-7_Human1.46562932
37MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.45067972
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.41871512
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.39432286
40IGF1R_20145208_ChIP-Seq_DFB_Human1.37206047
41GATA1_22025678_ChIP-Seq_K562_Human1.35163205
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32879211
43PADI4_21655091_ChIP-ChIP_MCF-7_Human1.31284263
44ELK1_19687146_ChIP-ChIP_HELA_Human1.31059308
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.30174967
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26307393
47STAT3_23295773_ChIP-Seq_U87_Human1.24191677
48CRX_20693478_ChIP-Seq_RETINA_Mouse1.24022808
49PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23782069
50ZNF274_21170338_ChIP-Seq_K562_Hela1.23733724
51AR_21909140_ChIP-Seq_LNCAP_Human1.21919053
52TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20990424
53SCL_19346495_ChIP-Seq_HPC-7_Human1.20798142
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20620459
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20493404
56SMAD4_21799915_ChIP-Seq_A2780_Human1.17850713
57RUNX_20019798_ChIP-Seq_JUKART_Human1.17703502
58FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.17550406
59TP53_16413492_ChIP-PET_HCT116_Human1.17417757
60OCT4_21477851_ChIP-Seq_ESCs_Mouse1.16751015
61HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.16516526
62E2F1_18555785_Chip-Seq_ESCs_Mouse1.15705931
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15175862
64NANOG_18555785_Chip-Seq_ESCs_Mouse1.15151475
65VDR_23849224_ChIP-Seq_CD4+_Human1.15068336
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.13465052
67FOXM1_26456572_ChIP-Seq_MCF-7_Human1.10931644
68CBP_20019798_ChIP-Seq_JUKART_Human1.10820887
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10820887
70FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.10666521
71SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.10359282
72TCF4_23295773_ChIP-Seq_U87_Human1.08959195
73OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08623921
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08372566
75RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.07553573
76FLI1_21867929_ChIP-Seq_TH2_Mouse1.07073979
77BCAT_22108803_ChIP-Seq_LS180_Human1.06001619
78TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05399101
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05025724
80ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.03258853
81NFYB_21822215_ChIP-Seq_K562_Human1.02290211
82CMYC_18555785_Chip-Seq_ESCs_Mouse1.02167055
83KDM2B_26808549_Chip-Seq_REH_Human1.01533752
84EST1_17652178_ChIP-ChIP_JURKAT_Human1.01299004
85PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01081986
86TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01002522
87CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00396727
88P300_18555785_Chip-Seq_ESCs_Mouse0.99841269
89TBL1_22424771_ChIP-Seq_293T_Human0.99304063
90SALL4_22934838_ChIP-ChIP_CD34+_Human0.99099798
91YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98079267
92SMAD3_21741376_ChIP-Seq_HESCs_Human0.98004206
93TCF4_22108803_ChIP-Seq_LS180_Human0.97501577
94SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97212394
95STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.97149701
96P53_22387025_ChIP-Seq_ESCs_Mouse0.96527418
97PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.95830960
98JUN_21703547_ChIP-Seq_K562_Human0.95818346
99SMAD4_21741376_ChIP-Seq_EPCs_Human0.94057172
100RXR_22108803_ChIP-Seq_LS180_Human0.93457943

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.33544837
2MP0003890_abnormal_embryonic-extraembry5.20193513
3MP0010094_abnormal_chromosome_stability3.58858343
4MP0008058_abnormal_DNA_repair3.24723656
5MP0000569_abnormal_digit_pigmentation3.14912827
6MP0003646_muscle_fatigue3.05746768
7MP0002102_abnormal_ear_morphology3.05556857
8MP0002009_preneoplasia2.39683441
9MP0003763_abnormal_thymus_physiology2.37009780
10MP0010307_abnormal_tumor_latency2.22626104
11MP0000015_abnormal_ear_pigmentation2.21075221
12MP0002396_abnormal_hematopoietic_system2.14420295
13MP0005499_abnormal_olfactory_system2.13693889
14MP0005394_taste/olfaction_phenotype2.13693889
15MP0003111_abnormal_nucleus_morphology2.13425119
16MP0010352_gastrointestinal_tract_polyps2.11104367
17MP0003077_abnormal_cell_cycle2.10690233
18MP0004957_abnormal_blastocyst_morpholog2.06496587
19MP0009697_abnormal_copulation1.85588840
20MP0008877_abnormal_DNA_methylation1.85250453
21MP0001984_abnormal_olfaction1.84266221
22MP0005671_abnormal_response_to1.75065691
23MP0003787_abnormal_imprinting1.71803811
24MP0000427_abnormal_hair_cycle1.69630752
25MP0006276_abnormal_autonomic_nervous1.61380590
26MP0005266_abnormal_metabolism1.56655458
27MP0001501_abnormal_sleep_pattern1.56522654
28MP0005075_abnormal_melanosome_morpholog1.51279704
29MP0004381_abnormal_hair_follicle1.50647214
30MP0003786_premature_aging1.47372642
31MP0001286_abnormal_eye_development1.39343212
32MP0006292_abnormal_olfactory_placode1.39052246
33MP0003121_genomic_imprinting1.38605138
34MP0003183_abnormal_peptide_metabolism1.33992944
35MP0001293_anophthalmia1.31706003
36MP0000631_abnormal_neuroendocrine_gland1.25998523
37MP0002166_altered_tumor_susceptibility1.25311050
38MP0003937_abnormal_limbs/digits/tail_de1.18485821
39MP0001672_abnormal_embryogenesis/_devel1.18313805
40MP0005380_embryogenesis_phenotype1.18313805
41MP0003195_calcinosis1.09965323
42MP0005174_abnormal_tail_pigmentation1.09657191
43MP0008007_abnormal_cellular_replicative1.08928772
44MP0000350_abnormal_cell_proliferation1.08140665
45MP0003984_embryonic_growth_retardation1.07891370
46MP0006054_spinal_hemorrhage1.07756009
47MP0001853_heart_inflammation1.07724849
48MP0002088_abnormal_embryonic_growth/wei1.06016103
49MP0008932_abnormal_embryonic_tissue1.05507622
50MP0000566_synostosis1.05442391
51MP0004145_abnormal_muscle_electrophysio1.02546675
52MP0000703_abnormal_thymus_morphology0.98148325
53MP0004133_heterotaxia0.94374530
54MP0001730_embryonic_growth_arrest0.94172562
55MP0000383_abnormal_hair_follicle0.92256985
56MP0001929_abnormal_gametogenesis0.92009853
57MP0002084_abnormal_developmental_patter0.91597399
58MP0002019_abnormal_tumor_incidence0.91526974
59MP0003943_abnormal_hepatobiliary_system0.88511452
60MP0000428_abnormal_craniofacial_morphol0.88250796
61MP0003567_abnormal_fetal_cardiomyocyte0.87976591
62MP0002398_abnormal_bone_marrow0.87517528
63MP0002736_abnormal_nociception_after0.86393966
64MP0002938_white_spotting0.86045551
65MP0002086_abnormal_extraembryonic_tissu0.85864803
66MP0003828_pulmonary_edema0.84611752
67MP0003936_abnormal_reproductive_system0.84367149
68MP0001697_abnormal_embryo_size0.82954566
69MP0004808_abnormal_hematopoietic_stem0.82861406
70MP0001119_abnormal_female_reproductive0.82198999
71MP0003693_abnormal_embryo_hatching0.81910336
72MP0002254_reproductive_system_inflammat0.80440067
73MP0005647_abnormal_sex_gland0.80403074
74MP0001324_abnormal_eye_pigmentation0.77402179
75MP0002095_abnormal_skin_pigmentation0.76982320
76MP0002210_abnormal_sex_determination0.76845685
77MP0000653_abnormal_sex_gland0.74558426
78MP0002085_abnormal_embryonic_tissue0.72758575
79MP0004197_abnormal_fetal_growth/weight/0.71678184
80MP0002697_abnormal_eye_size0.70774240
81MP0003119_abnormal_digestive_system0.70584770
82MP0001485_abnormal_pinna_reflex0.69989504
83MP0000689_abnormal_spleen_morphology0.69645336
84MP0003698_abnormal_male_reproductive0.68734123
85MP0008004_abnormal_stomach_pH0.67950908
86MP0005551_abnormal_eye_electrophysiolog0.66618512
87MP0002006_tumorigenesis0.66428046
88MP0001145_abnormal_male_reproductive0.65651285
89MP0003656_abnormal_erythrocyte_physiolo0.65371296
90MP0002111_abnormal_tail_morphology0.65320750
91MP0005367_renal/urinary_system_phenotyp0.64536265
92MP0000516_abnormal_urinary_system0.64536265
93MP0001873_stomach_inflammation0.63746529
94MP0002109_abnormal_limb_morphology0.63167187
95MP0004185_abnormal_adipocyte_glucose0.62866943
96MP0001881_abnormal_mammary_gland0.62030257
97MP0002177_abnormal_outer_ear0.60117567
98MP0010678_abnormal_skin_adnexa0.58977653
99MP0006072_abnormal_retinal_apoptosis0.58433148
100MP0002168_other_aberrant_phenotype0.57947424

Predicted human phenotypes

RankGene SetZ-score
1Cutaneous melanoma (HP:0012056)3.83036879
2Sensory axonal neuropathy (HP:0003390)3.82592056
3Volvulus (HP:0002580)3.21975536
4Abnormality of the fetal cardiovascular system (HP:0010948)3.11445975
5Abnormal umbilical cord blood vessels (HP:0011403)3.11445975
6Single umbilical artery (HP:0001195)3.11445975
7T lymphocytopenia (HP:0005403)3.06944780
8Genetic anticipation (HP:0003743)3.02885085
9Abnormality of chromosome stability (HP:0003220)3.01177925
10Protruding tongue (HP:0010808)2.95614039
11Absent radius (HP:0003974)2.84490939
12Chromosomal breakage induced by crosslinking agents (HP:0003221)2.78463974
13Abnormality of T cell number (HP:0011839)2.71818529
14Acute myeloid leukemia (HP:0004808)2.71703709
15Papillary thyroid carcinoma (HP:0002895)2.67422512
16Thyroiditis (HP:0100646)2.66677560
17Absent forearm bone (HP:0003953)2.62632087
18Aplasia involving forearm bones (HP:0009822)2.62632087
19Acute lymphatic leukemia (HP:0006721)2.58449641
20Scotoma (HP:0000575)2.54203713
21Central scotoma (HP:0000603)2.53541008
22Chromsome breakage (HP:0040012)2.52329265
23Abnormality of the labia minora (HP:0012880)2.50819756
24Clubbing of toes (HP:0100760)2.47737213
25Aplasia/Hypoplasia of the uvula (HP:0010293)2.44949371
26IgM deficiency (HP:0002850)2.41657206
27Growth hormone deficiency (HP:0000824)2.38861782
28Cupped ear (HP:0000378)2.37195320
29Meningioma (HP:0002858)2.37071377
30Abnormality of the fingertips (HP:0001211)2.36801612
31Prostate neoplasm (HP:0100787)2.36060069
32Chronic hepatic failure (HP:0100626)2.35275212
33Abolished electroretinogram (ERG) (HP:0000550)2.35212337
34Clumsiness (HP:0002312)2.32458782
35Colon cancer (HP:0003003)2.27751717
36Aqueductal stenosis (HP:0002410)2.27183938
37Prominent nose (HP:0000448)2.21811601
38Cellular immunodeficiency (HP:0005374)2.21598995
39Birth length less than 3rd percentile (HP:0003561)2.18989869
40Attenuation of retinal blood vessels (HP:0007843)2.18360374
41Slow saccadic eye movements (HP:0000514)2.16784258
42Abnormality of the columella (HP:0009929)2.10985346
43Nephroblastoma (Wilms tumor) (HP:0002667)2.10714809
44Fair hair (HP:0002286)2.10549628
45Embryonal renal neoplasm (HP:0011794)2.10376684
46Long eyelashes (HP:0000527)2.10334471
47Rhabdomyosarcoma (HP:0002859)2.08305479
48Aplasia/Hypoplasia of the earlobes (HP:0009906)2.01765994
49Oligodactyly (hands) (HP:0001180)2.01260890
50Triphalangeal thumb (HP:0001199)1.99397348
51Intestinal atresia (HP:0011100)1.97804493
52Bony spicule pigmentary retinopathy (HP:0007737)1.96811146
53Anal stenosis (HP:0002025)1.96621957
54Neoplasm of the adrenal cortex (HP:0100641)1.96046913
55Cerebral hypomyelination (HP:0006808)1.93384012
56Abnormal hair whorl (HP:0010721)1.93121347
57Abnormality of the preputium (HP:0100587)1.90998868
58Abnormality of the parathyroid morphology (HP:0011766)1.88574750
59Tubular atrophy (HP:0000092)1.87420515
60Medulloblastoma (HP:0002885)1.85482282
61Esophageal atresia (HP:0002032)1.84244004
62Sloping forehead (HP:0000340)1.84227804
63Abnormal auditory evoked potentials (HP:0006958)1.82499835
64Tubulointerstitial fibrosis (HP:0005576)1.80746800
65Constricted visual fields (HP:0001133)1.80557900
66Abnormal ventriculo-arterial connection (HP:0011563)1.80097576
67Transposition of the great arteries (HP:0001669)1.80097576
68Abnormal connection of the cardiac segments (HP:0011545)1.80097576
69Hematochezia (HP:0002573)1.78618195
70Abdominal situs inversus (HP:0003363)1.78495801
71Abnormality of abdominal situs (HP:0011620)1.78495801
72Tubulointerstitial abnormality (HP:0001969)1.77973180
73Thyroid carcinoma (HP:0002890)1.77968959
74IgA deficiency (HP:0002720)1.74703464
75Hip dysplasia (HP:0001385)1.73646265
76Meckel diverticulum (HP:0002245)1.73533427
77Neoplasm of the small intestine (HP:0100833)1.72688317
78Truncal obesity (HP:0001956)1.72127158
79Depressed nasal tip (HP:0000437)1.71907762
80Duplication of thumb phalanx (HP:0009942)1.71821450
81Abnormality of the duodenum (HP:0002246)1.71372263
82Thoracolumbar scoliosis (HP:0002944)1.71087083
83Gaze-evoked nystagmus (HP:0000640)1.70735589
84Abnormality of B cell number (HP:0010975)1.70642681
85Sandal gap (HP:0001852)1.69834044
86Preaxial foot polydactyly (HP:0001841)1.69134912
87Downturned corners of mouth (HP:0002714)1.68547408
88Abnormality of homocysteine metabolism (HP:0010919)1.68091907
89Homocystinuria (HP:0002156)1.68091907
90Abnormality of alanine metabolism (HP:0010916)1.67762187
91Hyperalaninemia (HP:0003348)1.67762187
92Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.67762187
93Autoimmune hemolytic anemia (HP:0001890)1.65415240
94Retinal dysplasia (HP:0007973)1.65308630
95Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.65308202
96Severe combined immunodeficiency (HP:0004430)1.64568443
97Progressive inability to walk (HP:0002505)1.64515024
98Glioma (HP:0009733)1.63720559
99Abnormality of the ileum (HP:0001549)1.63057360
100Hypoalphalipoproteinemia (HP:0003233)1.62213277

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.44019237
2ACVR1B3.88010042
3EIF2AK33.74957296
4PKN23.66427506
5MKNK23.54343145
6LATS13.20529474
7BRD42.85233187
8BRSK22.71469471
9NUAK12.58746806
10BMPR1B2.43466574
11FLT32.27661077
12INSRR2.10290637
13ZAK2.04011734
14MKNK12.00287630
15PRKD31.99139334
16CDC71.73531918
17NLK1.69178414
18AKT31.62197602
19TRIM281.53803247
20MAP3K41.43508317
21MELK1.42230039
22PLK41.41219457
23TEC1.36959412
24SRPK11.34216806
25CDK121.27071216
26CAMKK21.25764554
27STK31.22146679
28ERBB31.21830987
29MAP3K61.21220618
30TNIK1.18268159
31CHEK21.15885044
32VRK11.15048172
33WEE11.14747485
34MAP3K101.13462305
35EIF2AK21.11621663
36BCKDK1.08489097
37PBK1.05654020
38BUB11.02883884
39PLK10.99302935
40CDK60.98105131
41TTK0.97047337
42TXK0.93417764
43PLK30.92525068
44WNK30.91604291
45SGK20.91118023
46PRKCH0.91048946
47TLK10.90692136
48ATR0.90382127
49OBSCN0.89273194
50ERBB40.88559664
51CDK190.86522725
52IRAK10.79718067
53OXSR10.79271514
54CDK40.78485694
55CAMK1G0.77545002
56FGFR20.77082827
57BTK0.76167480
58IKBKE0.75785777
59NEK20.74146747
60STK40.70418829
61CAMK1D0.69694892
62IRAK40.69366569
63BLK0.69086398
64ATM0.69034917
65CDK30.66240089
66CHEK10.62824153
67RPS6KB20.59992697
68BRAF0.59247900
69BRSK10.58705655
70PIK3CG0.58129415
71MAPK130.55467317
72TSSK60.53307549
73SYK0.50962331
74IRAK20.50849607
75PIM10.50814076
76GRK10.50779657
77TGFBR10.47159528
78ITK0.47142588
79WNK10.44566493
80HCK0.44353247
81PRKAA20.43800296
82FGFR10.43256081
83SGK4940.43228145
84SGK2230.43228145
85TRPM70.42797250
86MAP3K120.40364954
87STK100.39134370
88CDK20.36524639
89NEK10.36263350
90PIK3CA0.36261532
91SGK30.34217269
92AURKB0.32892378
93PRKAA10.32188877
94TAF10.31145048
95SIK30.30696859
96STK390.30494558
97PRKCB0.30101818
98YES10.27436763
99CDK10.25233252
100PRKD20.24280565

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034504.84124922
2Fanconi anemia pathway_Homo sapiens_hsa034602.88451264
3Cell cycle_Homo sapiens_hsa041102.76616370
4Homologous recombination_Homo sapiens_hsa034402.41474959
5Systemic lupus erythematosus_Homo sapiens_hsa053222.13763229
6RNA degradation_Homo sapiens_hsa030182.09358219
7Base excision repair_Homo sapiens_hsa034102.04587306
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.00710557
9DNA replication_Homo sapiens_hsa030301.99090423
10p53 signaling pathway_Homo sapiens_hsa041151.95501388
11RNA polymerase_Homo sapiens_hsa030201.93323350
12Mismatch repair_Homo sapiens_hsa034301.86238697
13Non-small cell lung cancer_Homo sapiens_hsa052231.85545455
14Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.83263463
15Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.81106776
16Basal transcription factors_Homo sapiens_hsa030221.66154146
17Melanoma_Homo sapiens_hsa052181.47906750
18Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.45282406
19Lysine degradation_Homo sapiens_hsa003101.45023089
20MicroRNAs in cancer_Homo sapiens_hsa052061.42823373
21Alcoholism_Homo sapiens_hsa050341.40513154
22mRNA surveillance pathway_Homo sapiens_hsa030151.39213987
23Colorectal cancer_Homo sapiens_hsa052101.36044478
24Pancreatic cancer_Homo sapiens_hsa052121.35020789
25Selenocompound metabolism_Homo sapiens_hsa004501.32670622
26Butanoate metabolism_Homo sapiens_hsa006501.28212870
27Primary immunodeficiency_Homo sapiens_hsa053401.24209687
28Olfactory transduction_Homo sapiens_hsa047401.23198892
29Nucleotide excision repair_Homo sapiens_hsa034201.22107580
30Prostate cancer_Homo sapiens_hsa052151.22069202
31TGF-beta signaling pathway_Homo sapiens_hsa043501.16704400
32Pyrimidine metabolism_Homo sapiens_hsa002401.16314810
33Measles_Homo sapiens_hsa051621.15095179
34Circadian rhythm_Homo sapiens_hsa047101.13579444
35Glioma_Homo sapiens_hsa052141.12426462
36Viral carcinogenesis_Homo sapiens_hsa052031.12397008
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.12336417
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.10933941
39Oocyte meiosis_Homo sapiens_hsa041141.10816091
40Caffeine metabolism_Homo sapiens_hsa002321.09813978
41T cell receptor signaling pathway_Homo sapiens_hsa046601.08544297
42RNA transport_Homo sapiens_hsa030131.03813037
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.97195793
44Thyroid cancer_Homo sapiens_hsa052160.96314029
45Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.95076020
46Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92784961
47Dorso-ventral axis formation_Homo sapiens_hsa043200.92542829
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92441229
49Fatty acid biosynthesis_Homo sapiens_hsa000610.92395150
50Spliceosome_Homo sapiens_hsa030400.92044245
51FoxO signaling pathway_Homo sapiens_hsa040680.91745279
52One carbon pool by folate_Homo sapiens_hsa006700.89940286
53Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89676644
54Purine metabolism_Homo sapiens_hsa002300.84658313
55Chronic myeloid leukemia_Homo sapiens_hsa052200.84251276
56Taste transduction_Homo sapiens_hsa047420.82215520
57Small cell lung cancer_Homo sapiens_hsa052220.81601409
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80141262
59B cell receptor signaling pathway_Homo sapiens_hsa046620.77367238
60Protein export_Homo sapiens_hsa030600.76179344
61Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.75835012
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74484820
63Hepatitis B_Homo sapiens_hsa051610.69371944
64Endometrial cancer_Homo sapiens_hsa052130.65515167
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.63908312
66Propanoate metabolism_Homo sapiens_hsa006400.62618525
67Wnt signaling pathway_Homo sapiens_hsa043100.61687331
68Herpes simplex infection_Homo sapiens_hsa051680.61491230
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58807173
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57728863
71Acute myeloid leukemia_Homo sapiens_hsa052210.53441841
72Inositol phosphate metabolism_Homo sapiens_hsa005620.52807925
73HTLV-I infection_Homo sapiens_hsa051660.50839361
74ABC transporters_Homo sapiens_hsa020100.50698292
75NF-kappa B signaling pathway_Homo sapiens_hsa040640.49970637
76Platelet activation_Homo sapiens_hsa046110.46257646
77Tryptophan metabolism_Homo sapiens_hsa003800.45043124
78Graft-versus-host disease_Homo sapiens_hsa053320.44739282
79Peroxisome_Homo sapiens_hsa041460.44601475
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43775338
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43476455
82Basal cell carcinoma_Homo sapiens_hsa052170.41848111
83Calcium signaling pathway_Homo sapiens_hsa040200.41575948
84Vitamin digestion and absorption_Homo sapiens_hsa049770.37424376
85Epstein-Barr virus infection_Homo sapiens_hsa051690.36420747
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.36001174
87Nicotine addiction_Homo sapiens_hsa050330.35843110
88Type II diabetes mellitus_Homo sapiens_hsa049300.35603365
89Pathways in cancer_Homo sapiens_hsa052000.35384349
90Serotonergic synapse_Homo sapiens_hsa047260.33359251
91Renal cell carcinoma_Homo sapiens_hsa052110.33278452
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32861828
93Hippo signaling pathway_Homo sapiens_hsa043900.31568372
94Sulfur relay system_Homo sapiens_hsa041220.31151584
95Adherens junction_Homo sapiens_hsa045200.30985355
96Linoleic acid metabolism_Homo sapiens_hsa005910.30410445
97mTOR signaling pathway_Homo sapiens_hsa041500.30306207
98Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.29467401
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29332863
100Hedgehog signaling pathway_Homo sapiens_hsa043400.29301280

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