DDX19A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.70819230
2maturation of 5.8S rRNA (GO:0000460)4.65261571
3regulation of nuclear cell cycle DNA replication (GO:0033262)4.63501628
4nuclear pore organization (GO:0006999)4.57078253
5protein localization to kinetochore (GO:0034501)4.52103052
6DNA unwinding involved in DNA replication (GO:0006268)4.46765638
7folic acid-containing compound biosynthetic process (GO:0009396)4.36421866
8pseudouridine synthesis (GO:0001522)4.22632997
9pre-miRNA processing (GO:0031054)4.04120594
10mitotic nuclear envelope disassembly (GO:0007077)4.03833639
11heterochromatin organization (GO:0070828)3.96612579
12mitochondrial RNA metabolic process (GO:0000959)3.90908645
13kynurenine metabolic process (GO:0070189)3.83812975
14mitotic chromosome condensation (GO:0007076)3.83539751
15sister chromatid segregation (GO:0000819)3.81973503
16somatic hypermutation of immunoglobulin genes (GO:0016446)3.81150458
17somatic diversification of immune receptors via somatic mutation (GO:0002566)3.81150458
18L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.80289835
19membrane disassembly (GO:0030397)3.78817451
20nuclear envelope disassembly (GO:0051081)3.78817451
21mitotic sister chromatid segregation (GO:0000070)3.73763519
22protein localization to chromosome, centromeric region (GO:0071459)3.70793806
23regulation of translational fidelity (GO:0006450)3.69235461
24RNA stabilization (GO:0043489)3.68202095
25mRNA stabilization (GO:0048255)3.68202095
26ubiquinone biosynthetic process (GO:0006744)3.62204592
27behavioral response to nicotine (GO:0035095)3.61371345
28regulation of sister chromatid cohesion (GO:0007063)3.58255953
29mitotic sister chromatid cohesion (GO:0007064)3.57032115
30maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.49332675
31ubiquinone metabolic process (GO:0006743)3.49110796
32histone H2A monoubiquitination (GO:0035518)3.48523260
33lysine catabolic process (GO:0006554)3.47727787
34lysine metabolic process (GO:0006553)3.47727787
35pore complex assembly (GO:0046931)3.47027827
36tRNA modification (GO:0006400)3.44926368
37rRNA catabolic process (GO:0016075)3.42026738
38dosage compensation (GO:0007549)3.40402814
39aspartate family amino acid catabolic process (GO:0009068)3.38636362
40meiotic chromosome segregation (GO:0045132)3.34162582
41negative regulation of DNA-dependent DNA replication (GO:2000104)3.33625754
42chromatin assembly (GO:0031497)3.33222952
43negative regulation of histone methylation (GO:0031061)3.32084041
44ribosome biogenesis (GO:0042254)3.28361476
45DNA duplex unwinding (GO:0032508)3.27564810
46intra-S DNA damage checkpoint (GO:0031573)3.26847461
47DNA geometric change (GO:0032392)3.24005304
48protein import into peroxisome matrix (GO:0016558)3.21668115
49DNA replication-dependent nucleosome assembly (GO:0006335)3.20916723
50DNA replication-dependent nucleosome organization (GO:0034723)3.20916723
51replication fork processing (GO:0031297)3.19922901
52negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.19887917
53water-soluble vitamin biosynthetic process (GO:0042364)3.15372645
54L-methionine salvage (GO:0071267)3.12140019
55L-methionine biosynthetic process (GO:0071265)3.12140019
56amino acid salvage (GO:0043102)3.12140019
57regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.11959308
58DNA strand renaturation (GO:0000733)3.10200853
59tryptophan metabolic process (GO:0006568)3.09629380
603-UTR-mediated mRNA stabilization (GO:0070935)3.09403036
61positive regulation of histone deacetylation (GO:0031065)3.09262258
62nuclear envelope organization (GO:0006998)3.07999563
63regulation of centrosome cycle (GO:0046605)3.07587226
64regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.06112029
65regulation of mitotic spindle checkpoint (GO:1903504)3.06112029
66L-fucose catabolic process (GO:0042355)3.06022545
67fucose catabolic process (GO:0019317)3.06022545
68L-fucose metabolic process (GO:0042354)3.06022545
69peptidyl-histidine modification (GO:0018202)3.04735529
70regulation of RNA export from nucleus (GO:0046831)3.02708918
71methionine biosynthetic process (GO:0009086)3.01846861
72negative regulation of RNA splicing (GO:0033119)3.01312665
73IMP biosynthetic process (GO:0006188)3.00912594
74positive regulation of chromosome segregation (GO:0051984)2.99882381
75regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.99746417
76regulation of centriole replication (GO:0046599)2.95131696
77regulation of translational termination (GO:0006449)2.94485683
78regulation of spindle organization (GO:0090224)2.93392488
79tRNA processing (GO:0008033)2.92372662
80peptidyl-lysine dimethylation (GO:0018027)2.90843506
81glucocorticoid receptor signaling pathway (GO:0042921)2.90502407
82NLS-bearing protein import into nucleus (GO:0006607)2.90414157
83tRNA methylation (GO:0030488)2.89573499
84rRNA modification (GO:0000154)2.88833639
85indole-containing compound catabolic process (GO:0042436)2.87104815
86indolalkylamine catabolic process (GO:0046218)2.87104815
87tryptophan catabolic process (GO:0006569)2.87104815
88positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.85582264
89positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.85582264
90positive regulation of mitotic sister chromatid separation (GO:1901970)2.85582264
91IMP metabolic process (GO:0046040)2.84555143
92mitotic metaphase plate congression (GO:0007080)2.84287458
93regulation of mitotic spindle organization (GO:0060236)2.84136457
94regulation of histone H3-K9 methylation (GO:0051570)2.83263309
95spliceosomal snRNP assembly (GO:0000387)2.82621729
96protein localization to chromosome (GO:0034502)2.82519405
97regulation of mRNA stability (GO:0043488)2.81529968
98ribosome assembly (GO:0042255)2.80888589
99DNA damage induced protein phosphorylation (GO:0006975)2.80824976
100regulation of centrosome duplication (GO:0010824)2.79746768
101DNA replication initiation (GO:0006270)2.78684055
102rRNA methylation (GO:0031167)2.78114713
103maternal placenta development (GO:0001893)2.77439530
104positive regulation of SMAD protein import into nucleus (GO:0060391)2.77294262
105mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.76455418
106mitochondrial respiratory chain complex I assembly (GO:0032981)2.76455418
107NADH dehydrogenase complex assembly (GO:0010257)2.76455418
108RNA modification (GO:0009451)2.75722125
109negative regulation of mRNA processing (GO:0050686)2.75385923
110chromatin assembly or disassembly (GO:0006333)2.75369460
111tRNA metabolic process (GO:0006399)2.74661333
112replicative senescence (GO:0090399)2.74217406
113trophectodermal cell differentiation (GO:0001829)2.73679769
114spliceosomal tri-snRNP complex assembly (GO:0000244)2.73525433
115recombinational repair (GO:0000725)2.72949940
116double-strand break repair via homologous recombination (GO:0000724)2.72820673
117regulation of RNA stability (GO:0043487)2.72669324
118reciprocal meiotic recombination (GO:0007131)2.71878226
119reciprocal DNA recombination (GO:0035825)2.71878226
120nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.71535950
121DNA deamination (GO:0045006)2.71121623
122DNA strand elongation involved in DNA replication (GO:0006271)2.71116086
123formation of translation preinitiation complex (GO:0001731)2.70662103
124ncRNA processing (GO:0034470)2.69234403
125aspartate family amino acid biosynthetic process (GO:0009067)2.68155877
126negative regulation of mRNA metabolic process (GO:1903312)2.67325412
127paraxial mesoderm development (GO:0048339)2.67132168
128ribonucleoprotein complex biogenesis (GO:0022613)2.66421005
129rRNA metabolic process (GO:0016072)2.65491304
130nucleobase biosynthetic process (GO:0046112)2.64543504
131intracellular estrogen receptor signaling pathway (GO:0030520)2.64514606
132rRNA processing (GO:0006364)2.64050731
133sulfur amino acid biosynthetic process (GO:0000097)2.63568115
134ncRNA metabolic process (GO:0034660)2.63108491
135T cell apoptotic process (GO:0070231)2.62554220
136quinone biosynthetic process (GO:1901663)2.60938401
137RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.60902921
138regulation of posttranscriptional gene silencing (GO:0060147)2.60476673
139regulation of gene silencing by miRNA (GO:0060964)2.60476673
140regulation of gene silencing by RNA (GO:0060966)2.60476673
141gene silencing by RNA (GO:0031047)2.60460547
142cellular ketone body metabolic process (GO:0046950)2.58966780
143response to UV-C (GO:0010225)2.58819969
144DNA conformation change (GO:0071103)2.58771913
145tetrahydrofolate metabolic process (GO:0046653)2.58602254
146mitochondrial respiratory chain complex assembly (GO:0033108)2.58160789
147inner cell mass cell proliferation (GO:0001833)2.57235582
148chromosome condensation (GO:0030261)2.55815958
149DNA strand elongation (GO:0022616)2.55778503
150DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.54412840
151indolalkylamine metabolic process (GO:0006586)2.53976119
152ncRNA catabolic process (GO:0034661)2.53196022
153regulation of stem cell maintenance (GO:2000036)2.52996388
154translesion synthesis (GO:0019985)2.52974634
155regulation of hippo signaling (GO:0035330)2.52907323
156maturation of SSU-rRNA (GO:0030490)2.52097237
157metaphase plate congression (GO:0051310)2.51202597
158methionine metabolic process (GO:0006555)2.50844145
159aspartate family amino acid metabolic process (GO:0009066)2.50250492
160regulation of telomere maintenance via telomerase (GO:0032210)2.48715506
161cellular component biogenesis (GO:0044085)2.48122256
162regulation of mitochondrial translation (GO:0070129)2.47784626
163transcription elongation from RNA polymerase I promoter (GO:0006362)2.47575360
164preassembly of GPI anchor in ER membrane (GO:0016254)2.46945831
165negative regulation of telomere maintenance (GO:0032205)2.45761128
166corticosteroid receptor signaling pathway (GO:0031958)2.45182028
167DNA replication checkpoint (GO:0000076)2.44718385
168regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.44098299
169folic acid metabolic process (GO:0046655)2.43350194
170DNA methylation involved in gamete generation (GO:0043046)2.42840727
171respiratory chain complex IV assembly (GO:0008535)2.42753254
172histone H2A ubiquitination (GO:0033522)2.42527377
173positive regulation of gene expression, epigenetic (GO:0045815)2.41346709
174somatic diversification of immunoglobulins (GO:0016445)2.41219108
175protein complex biogenesis (GO:0070271)2.40941374
176peptidyl-arginine omega-N-methylation (GO:0035247)2.40690410
177regulation of SMAD protein import into nucleus (GO:0060390)2.40202932
178gene silencing (GO:0016458)2.39964972
179apoptotic process involved in morphogenesis (GO:0060561)2.38298061
180alternative mRNA splicing, via spliceosome (GO:0000380)2.37722897
181regulation of chromosome segregation (GO:0051983)2.37131345
182regulation of nucleobase-containing compound transport (GO:0032239)2.36382904
183positive regulation of protein deacetylation (GO:0090312)2.36349690
184DNA damage response, signal transduction resulting in transcription (GO:0042772)2.33480669
185establishment of chromosome localization (GO:0051303)2.32209921
186* mRNA transport (GO:0051028)2.29937741
187chromosome segregation (GO:0007059)2.28991374
188cytoplasmic mRNA processing body assembly (GO:0033962)2.28846555
189regulation of protein heterodimerization activity (GO:0043497)2.27821100

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.24634948
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.07638570
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.86953551
4* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.81504070
5ZNF274_21170338_ChIP-Seq_K562_Hela3.80787623
6* ETS1_20019798_ChIP-Seq_JURKAT_Human3.52050123
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.50240665
8* MYC_22102868_ChIP-Seq_BL_Human3.47602021
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.36980110
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.27231902
11NOTCH1_21737748_ChIP-Seq_TLL_Human3.21524546
12* EST1_17652178_ChIP-ChIP_JURKAT_Human3.06978995
13* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.05591543
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.00970240
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.94207923
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.90469683
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.87661718
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.72319953
19MYC_18555785_ChIP-Seq_MESCs_Mouse2.67013642
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.40345690
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.26868154
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.25843302
23* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.22754365
24* SRF_21415370_ChIP-Seq_HL-1_Mouse2.19930085
25AR_21909140_ChIP-Seq_LNCAP_Human2.16016057
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.12375609
27MYC_18940864_ChIP-ChIP_HL60_Human2.04056093
28YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.03740504
29* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.03066046
30* DCP1A_22483619_ChIP-Seq_HELA_Human2.02691032
31* VDR_21846776_ChIP-Seq_THP-1_Human1.94822748
32E2F1_21310950_ChIP-Seq_MCF-7_Human1.94764028
33ELK1_19687146_ChIP-ChIP_HELA_Human1.90442917
34YY1_21170310_ChIP-Seq_MESCs_Mouse1.87594168
35TCF7_22412390_ChIP-Seq_EML_Mouse1.79295696
36* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.78401378
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.74555466
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.71976928
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.68021843
40* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.67500867
41CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.63180348
42TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61281943
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.57593147
44TP63_19390658_ChIP-ChIP_HaCaT_Human1.56360635
45KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.56142449
46* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.55933399
47CIITA_25753668_ChIP-Seq_RAJI_Human1.55441030
48CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.54809145
49* XRN2_22483619_ChIP-Seq_HELA_Human1.54282722
50IRF1_19129219_ChIP-ChIP_H3396_Human1.54120238
51KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.53458012
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.52408871
53PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.52146588
54BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.49830919
55TP63_17297297_ChIP-ChIP_HaCaT_Human1.48509513
56TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.47148348
57KDM2B_26808549_Chip-Seq_DND41_Human1.46712684
58UTX_26944678_Chip-Seq_JUKART_Human1.46480620
59SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.45232378
60MAF_26560356_Chip-Seq_TH1_Human1.44659421
61VDR_22108803_ChIP-Seq_LS180_Human1.44035167
62CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.43668162
63ELK3_25401928_ChIP-Seq_HUVEC_Human1.43211928
64ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37811440
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.37493932
66STAT3_1855785_ChIP-Seq_MESCs_Mouse1.35891366
67KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.34728300
68MYCN_18555785_ChIP-Seq_MESCs_Mouse1.33615456
69* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.33365758
70* KDM5A_27292631_Chip-Seq_BREAST_Human1.32586849
71EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32456856
72HIF1A_21447827_ChIP-Seq_MCF-7_Human1.30184864
73DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.29479982
74ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.28139289
75KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27340484
76POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.27210262
77MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.25658938
78EWS_26573619_Chip-Seq_HEK293_Human1.25431789
79CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24862533
80ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23768358
81CLOCK_20551151_ChIP-Seq_293T_Human1.23600575
82MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.22394710
83CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.22273388
84ATF3_27146783_Chip-Seq_COLON_Human1.21553312
85ESR1_15608294_ChIP-ChIP_MCF-7_Human1.21466250
86TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20476424
87NANOG_18555785_ChIP-Seq_MESCs_Mouse1.20113592
88POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16331494
89TP53_22573176_ChIP-Seq_HFKS_Human1.15953967
90CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.15418735
91SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.14436528
92NCOR1_26117541_ChIP-Seq_K562_Human1.13596536
93CHD1_26751641_Chip-Seq_LNCaP_Human1.12421290
94MYB_26560356_Chip-Seq_TH2_Human1.12172506
95KDM2B_26808549_Chip-Seq_SUP-B15_Human1.12094869
96MYB_26560356_Chip-Seq_TH1_Human1.12019392
97ZNF263_19887448_ChIP-Seq_K562_Human1.11810267
98NANOG_21062744_ChIP-ChIP_HESCs_Human1.11577104
99STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.11540629
100ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.10577617
101PKCTHETA_26484144_Chip-Seq_BREAST_Human1.10569070
102TFEB_21752829_ChIP-Seq_HELA_Human1.10002495
103FOXP1_21924763_ChIP-Seq_HESCs_Human1.07443229
104BRD4_27068464_Chip-Seq_AML-cells_Mouse1.07367041
105EGR1_23403033_ChIP-Seq_LIVER_Mouse1.06463112
106FUS_26573619_Chip-Seq_HEK293_Human1.05337387
107TCF3_18692474_ChIP-Seq_MEFs_Mouse1.03567360
108* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02832682
109KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02365284
110ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01800762
111PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01510586
112ERA_21632823_ChIP-Seq_H3396_Human1.01399231
113ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.00953518
114SCL_19346495_ChIP-Seq_HPC-7_Human0.99739443
115KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99507516
116P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99011273
117POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98834475
118NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.98646555
119SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.98534120
120HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97962394
121NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.97641485
122TTF2_22483619_ChIP-Seq_HELA_Human0.97391308
123KDM2B_26808549_Chip-Seq_JURKAT_Human0.96297567
124* GABP_19822575_ChIP-Seq_HepG2_Human0.96212468
125GATA6_25053715_ChIP-Seq_YYC3_Human0.96074662
126MAF_26560356_Chip-Seq_TH2_Human0.95834707
127PPARA_22158963_ChIP-Seq_LIVER_Mouse0.95681649
128* FOXP3_21729870_ChIP-Seq_TREG_Human0.95606433
129CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95286046
130VDR_24763502_ChIP-Seq_THP-1_Human0.95255715
131* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94497082
132TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94294768
133MYB_21317192_ChIP-Seq_ERMYB_Mouse0.94286377
134HOXB7_26014856_ChIP-Seq_BT474_Human0.94050103
135RACK7_27058665_Chip-Seq_MCF-7_Human0.93635334
136ZFP281_27345836_Chip-Seq_ESCs_Mouse0.93269710
137ELF1_17652178_ChIP-ChIP_JURKAT_Human0.92949873
138TBX5_21415370_ChIP-Seq_HL-1_Mouse0.92588901
139RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.92481472
140HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.91927103
141SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91341525
142E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.90342859
143SOX2_16153702_ChIP-ChIP_HESCs_Human0.90022504
144* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.89833083
145RUNX1_22412390_ChIP-Seq_EML_Mouse0.89218246
146ZFP281_18757296_ChIP-ChIP_E14_Mouse0.89010631
147SALL1_21062744_ChIP-ChIP_HESCs_Human0.87053677
148ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.87033399
149SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.85532713
150ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85456339
151* E2F1_17053090_ChIP-ChIP_MCF-7_Human0.84734291
152* VDR_23849224_ChIP-Seq_CD4+_Human0.84471434
153KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.83853320
154KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.83853320
155ERG_20887958_ChIP-Seq_HPC-7_Mouse0.81460880
156EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.81401205
157DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.78945748
158* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78517147
159SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.78262589
160AR_21572438_ChIP-Seq_LNCaP_Human0.78165706
161YY1_22570637_ChIP-Seq_MALME-3M_Human0.77521173
162PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.76041792
163SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.75547082
164PHF8_20622854_ChIP-Seq_HELA_Human0.74087885

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color3.88572959
2MP0003705_abnormal_hypodermis_morpholog3.43104003
3MP0003646_muscle_fatigue3.15052924
4MP0010352_gastrointestinal_tract_polyps3.13012580
5MP0005171_absent_coat_pigmentation3.03117691
6MP0004957_abnormal_blastocyst_morpholog2.76450263
7MP0003693_abnormal_embryo_hatching2.65665262
8MP0003111_abnormal_nucleus_morphology2.62452973
9MP0005076_abnormal_cell_differentiation2.60317906
10MP0010094_abnormal_chromosome_stability2.58044256
11MP0003077_abnormal_cell_cycle2.50759537
12MP0002938_white_spotting2.32325302
13MP0008057_abnormal_DNA_replication2.11782067
14MP0010307_abnormal_tumor_latency2.05022919
15MP0001730_embryonic_growth_arrest2.02706111
16MP0003300_gastrointestinal_ulcer2.00415294
17MP0008877_abnormal_DNA_methylation1.99105850
18MP0006292_abnormal_olfactory_placode1.97511461
19MP0000350_abnormal_cell_proliferation1.89396023
20MP0001661_extended_life_span1.87706014
21MP0003718_maternal_effect1.84662180
22MP0002396_abnormal_hematopoietic_system1.82838999
23MP0001672_abnormal_embryogenesis/_devel1.76397948
24MP0005380_embryogenesis_phenotype1.76397948
25MP0003984_embryonic_growth_retardation1.70711148
26MP0004197_abnormal_fetal_growth/weight/1.70468744
27MP0002088_abnormal_embryonic_growth/wei1.69612571
28MP0002086_abnormal_extraembryonic_tissu1.64536178
29MP0005083_abnormal_biliary_tract1.63425749
30MP0008875_abnormal_xenobiotic_pharmacok1.63097569
31MP0009053_abnormal_anal_canal1.62466940
32MP0004147_increased_porphyrin_level1.61702275
33MP0008007_abnormal_cellular_replicative1.60490717
34MP0002084_abnormal_developmental_patter1.60462384
35MP0002877_abnormal_melanocyte_morpholog1.58635865
36MP0003566_abnormal_cell_adhesion1.58524859
37MP0004808_abnormal_hematopoietic_stem1.57621075
38MP0002254_reproductive_system_inflammat1.57156055
39MP0003123_paternal_imprinting1.57084279
40MP0001697_abnormal_embryo_size1.56548570
41MP0010030_abnormal_orbit_morphology1.55202443
42MP0002085_abnormal_embryonic_tissue1.53768707
43MP0001849_ear_inflammation1.53550394
44MP0000372_irregular_coat_pigmentation1.53265040
45MP0003195_calcinosis1.52065168
46MP0000569_abnormal_digit_pigmentation1.51631549
47MP0001986_abnormal_taste_sensitivity1.51214284
48MP0001529_abnormal_vocalization1.50560731
49MP0010234_abnormal_vibrissa_follicle1.47359601
50MP0002876_abnormal_thyroid_physiology1.44040734
51MP0006035_abnormal_mitochondrial_morpho1.43662637
52MP0004264_abnormal_extraembryonic_tissu1.43340997
53MP0008872_abnormal_physiological_respon1.43296543
54MP0000537_abnormal_urethra_morphology1.40354200
55MP0000733_abnormal_muscle_development1.40345268
56MP0002837_dystrophic_cardiac_calcinosis1.39523792
57MP0002080_prenatal_lethality1.39042033
58MP0009278_abnormal_bone_marrow1.38577609
59MP0009697_abnormal_copulation1.38366794
60MP0004043_abnormal_pH_regulation1.38014994
61MP0003786_premature_aging1.35707705
62MP0000490_abnormal_crypts_of1.33869644
63MP0005023_abnormal_wound_healing1.33621002
64MP0005174_abnormal_tail_pigmentation1.31808408
65MP0005551_abnormal_eye_electrophysiolog1.31639538
66MP0004233_abnormal_muscle_weight1.29822309
67MP0001915_intracranial_hemorrhage1.28625327
68MP0004133_heterotaxia1.26847177
69MP0004185_abnormal_adipocyte_glucose1.24225863
70MP0003763_abnormal_thymus_physiology1.23800825
71MP0002638_abnormal_pupillary_reflex1.23245705
72MP0002160_abnormal_reproductive_system1.22570722
73MP0003121_genomic_imprinting1.22371256
74MP0002019_abnormal_tumor_incidence1.21540421
75MP0000703_abnormal_thymus_morphology1.18454135
76MP0006054_spinal_hemorrhage1.18053210
77MP0008932_abnormal_embryonic_tissue1.17737178
78MP0003890_abnormal_embryonic-extraembry1.17577703
79MP0000358_abnormal_cell_content/1.17083001
80MP0003950_abnormal_plasma_membrane1.16238453
81MP0004145_abnormal_muscle_electrophysio1.16210602
82MP0003567_abnormal_fetal_cardiomyocyte1.15438988
83MP0009672_abnormal_birth_weight1.15066696
84MP0003303_peritoneal_inflammation1.13081403
85MP0009384_cardiac_valve_regurgitation1.12846599
86MP0004142_abnormal_muscle_tone1.09722894
87MP0005646_abnormal_pituitary_gland1.08385135
88MP0000566_synostosis1.08023582
89MP0000428_abnormal_craniofacial_morphol1.06842868
90MP0002398_abnormal_bone_marrow1.06535232
91MP0001545_abnormal_hematopoietic_system1.06436612
92MP0005397_hematopoietic_system_phenotyp1.06436612
93MP0002102_abnormal_ear_morphology1.04495957
94MP0000313_abnormal_cell_death1.03523331
95MP0002092_abnormal_eye_morphology1.03007925
96MP0009333_abnormal_splenocyte_physiolog1.01658425
97MP0009046_muscle_twitch1.01541786
98MP0002722_abnormal_immune_system0.98583896
99MP0002925_abnormal_cardiovascular_devel0.97535660
100MP0008058_abnormal_DNA_repair0.97048505
101MP0002163_abnormal_gland_morphology0.96979495
102MP0006072_abnormal_retinal_apoptosis0.95604422
103MP0003453_abnormal_keratinocyte_physiol0.94445959
104MP0001293_anophthalmia0.93596050
105MP0009703_decreased_birth_body0.93086273
106MP0005253_abnormal_eye_physiology0.93077835
107MP0000689_abnormal_spleen_morphology0.92611396
108MP0004130_abnormal_muscle_cell0.92267883
109MP0002697_abnormal_eye_size0.91562961
110MP0000685_abnormal_immune_system0.90292499
111MP0002210_abnormal_sex_determination0.89976406
112MP0003115_abnormal_respiratory_system0.89132453
113MP0006036_abnormal_mitochondrial_physio0.88954215
114MP0000858_altered_metastatic_potential0.85697247
115MP0004947_skin_inflammation0.85031169
116MP0003119_abnormal_digestive_system0.84880303
117MP0001324_abnormal_eye_pigmentation0.84650847
118MP0003935_abnormal_craniofacial_develop0.82152491
119MP0002653_abnormal_ependyma_morphology0.81513595
120MP0010630_abnormal_cardiac_muscle0.81370783
121MP0008961_abnormal_basal_metabolism0.81065404
122MP0001929_abnormal_gametogenesis0.79713798
123MP0000477_abnormal_intestine_morphology0.79638881
124MP0002111_abnormal_tail_morphology0.79374438
125MP0002269_muscular_atrophy0.79344941
126MP0005391_vision/eye_phenotype0.79282004
127MP0000049_abnormal_middle_ear0.78876763
128MP0002075_abnormal_coat/hair_pigmentati0.78865320
129MP0005266_abnormal_metabolism0.78754706
130MP0000266_abnormal_heart_morphology0.78224348
131MP0000598_abnormal_liver_morphology0.77787338
132MP0003091_abnormal_cell_migration0.77733549
133MP0000427_abnormal_hair_cycle0.77676893
134MP0000750_abnormal_muscle_regeneration0.76389443
135MP0001800_abnormal_humoral_immune0.76357821
136MP0002932_abnormal_joint_morphology0.75875417
137MP0002429_abnormal_blood_cell0.75843973
138MP0002106_abnormal_muscle_physiology0.74871527
139MP0000631_abnormal_neuroendocrine_gland0.74555408
140MP0008770_decreased_survivor_rate0.74500207
141MP0002095_abnormal_skin_pigmentation0.74078622
142MP0005389_reproductive_system_phenotype0.73257464
143MP0005621_abnormal_cell_physiology0.73027340
144MP0005623_abnormal_meninges_morphology0.71796917
145MP0003937_abnormal_limbs/digits/tail_de0.71633116
146MP0000432_abnormal_head_morphology0.71615325
147MP0003698_abnormal_male_reproductive0.70784893
148MP0000371_diluted_coat_color0.70459571
149MP0001346_abnormal_lacrimal_gland0.70187603
150MP0000716_abnormal_immune_system0.68325747
151MP0000609_abnormal_liver_physiology0.68246699
152MP0001145_abnormal_male_reproductive0.68131780
153MP0002405_respiratory_system_inflammati0.68100581
154MP0002166_altered_tumor_susceptibility0.68025983
155MP0003448_altered_tumor_morphology0.67873745
156MP0005257_abnormal_intraocular_pressure0.67108739
157MP0005369_muscle_phenotype0.66189781
158MP0005195_abnormal_posterior_eye0.65960733
159MP0010368_abnormal_lymphatic_system0.65948822
160MP0003959_abnormal_lean_body0.65745912
161MP0000377_abnormal_hair_follicle0.65610646
162MP0008995_early_reproductive_senescence0.65416133
163MP0005410_abnormal_fertilization0.64418113
164MP0000653_abnormal_sex_gland0.64285107
165MP0005384_cellular_phenotype0.63377813
166MP0010155_abnormal_intestine_physiology0.62768772
167MP0005666_abnormal_adipose_tissue0.62538825
168MP0003943_abnormal_hepatobiliary_system0.62331828
169MP0005332_abnormal_amino_acid0.62204808
170MP0005501_abnormal_skin_physiology0.62072106
171MP0008775_abnormal_heart_ventricle0.62039545

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.30729837
2Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.01842840
3Abnormality of alanine metabolism (HP:0010916)4.01842840
4Hyperalaninemia (HP:0003348)4.01842840
5Abnormality of the pons (HP:0007361)3.61697915
6Hypoplasia of the pons (HP:0012110)3.27774639
7Ependymoma (HP:0002888)3.21488778
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.18130585
9Type II lissencephaly (HP:0007260)3.13584136
10Pancreatic cysts (HP:0001737)2.95238745
11Cerebellar dysplasia (HP:0007033)2.88810821
12Increased density of long bones (HP:0006392)2.77600260
13Breast hypoplasia (HP:0003187)2.77075735
14Duplicated collecting system (HP:0000081)2.72777668
15Abnormality of the fingertips (HP:0001211)2.70407461
16Short 4th metacarpal (HP:0010044)2.68248872
17Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.68248872
18Selective tooth agenesis (HP:0001592)2.64635213
19Large for gestational age (HP:0001520)2.61364754
20Increased nuchal translucency (HP:0010880)2.56059248
21Abnormality of the ileum (HP:0001549)2.54562932
22Meckel diverticulum (HP:0002245)2.54179827
23Attenuation of retinal blood vessels (HP:0007843)2.52573498
24Astrocytoma (HP:0009592)2.52236756
25Abnormality of the astrocytes (HP:0100707)2.52236756
26Hyperacusis (HP:0010780)2.51651725
27Deviation of the thumb (HP:0009603)2.50284886
28Abnormality of the renal collecting system (HP:0004742)2.48180450
29Pancreatic fibrosis (HP:0100732)2.44675907
30Pseudobulbar signs (HP:0002200)2.41756822
31Shallow orbits (HP:0000586)2.41521726
32Molar tooth sign on MRI (HP:0002419)2.40531581
33Abnormality of midbrain morphology (HP:0002418)2.40531581
34Severe muscular hypotonia (HP:0006829)2.40090027
35Cerebral aneurysm (HP:0004944)2.39122807
36Aplasia/Hypoplasia of the uvula (HP:0010293)2.38074534
37Abnormal number of erythroid precursors (HP:0012131)2.37185188
38Rhabdomyosarcoma (HP:0002859)2.36097045
39Abnormality of the renal cortex (HP:0011035)2.35778210
40Proximal placement of thumb (HP:0009623)2.34669765
41Protrusio acetabuli (HP:0003179)2.33949997
42Nephronophthisis (HP:0000090)2.33445219
43Renal duplication (HP:0000075)2.33365812
44Progressive inability to walk (HP:0002505)2.33086938
45Congenital stationary night blindness (HP:0007642)2.32014767
46Lissencephaly (HP:0001339)2.31571520
47Pendular nystagmus (HP:0012043)2.30676684
48Volvulus (HP:0002580)2.25397642
49Basal cell carcinoma (HP:0002671)2.24986733
50Abnormality of the carotid arteries (HP:0005344)2.24217971
51Abnormality of the 4th metacarpal (HP:0010012)2.23973152
52Gastrointestinal carcinoma (HP:0002672)2.23470993
53Malignant gastrointestinal tract tumors (HP:0006749)2.23470993
54Increased serum lactate (HP:0002151)2.23274192
55Medulloblastoma (HP:0002885)2.18567425
56Neoplasm of striated muscle (HP:0009728)2.17817484
57Cortical dysplasia (HP:0002539)2.17447926
58High pitched voice (HP:0001620)2.16387058
59Ulnar bowing (HP:0003031)2.16044286
60Chorioretinal atrophy (HP:0000533)2.15784258
61Rectal prolapse (HP:0002035)2.14793717
62Long eyelashes (HP:0000527)2.14590715
63Absent thumb (HP:0009777)2.12011207
64Protruding tongue (HP:0010808)2.11126478
65Colon cancer (HP:0003003)2.10139983
66True hermaphroditism (HP:0010459)2.09324270
67Lipid accumulation in hepatocytes (HP:0006561)2.08193125
68Prominent nose (HP:0000448)2.08100295
69Skin tags (HP:0010609)2.06671522
70Impulsivity (HP:0100710)2.06630718
71Short thumb (HP:0009778)2.03981579
72Abnormality of the renal medulla (HP:0100957)2.03956371
73Ankle contracture (HP:0006466)2.03312273
74Absent radius (HP:0003974)2.02375302
75Multiple enchondromatosis (HP:0005701)1.99044843
76Abnormality of cells of the erythroid lineage (HP:0012130)1.98719060
77Hypoplasia of the capital femoral epiphysis (HP:0003090)1.98309286
78Partial agenesis of the corpus callosum (HP:0001338)1.97782039
79Abnormality of DNA repair (HP:0003254)1.97096588
80Mitral valve prolapse (HP:0001634)1.96564145
81Aplasia involving forearm bones (HP:0009822)1.96298897
82Absent forearm bone (HP:0003953)1.96298897
83Inability to walk (HP:0002540)1.96171677
84Abnormality of the preputium (HP:0100587)1.95592469
85Sloping forehead (HP:0000340)1.95003965
86Biliary tract neoplasm (HP:0100574)1.94635723
87Increased CSF lactate (HP:0002490)1.94369632
88Spastic diplegia (HP:0001264)1.94098761
89Tubular atrophy (HP:0000092)1.93496819
90Subacute progressive viral hepatitis (HP:0006572)1.92746802
91Chronic hepatic failure (HP:0100626)1.92663742
92Renal cortical cysts (HP:0000803)1.92220586
93Genetic anticipation (HP:0003743)1.90874315
94Broad thumb (HP:0011304)1.89651445
95Preauricular skin tag (HP:0000384)1.89643719
96Concave nail (HP:0001598)1.88120370
97Type I transferrin isoform profile (HP:0003642)1.88051299
98Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.86343859
99Abnormal protein N-linked glycosylation (HP:0012347)1.86343859
100Abnormal protein glycosylation (HP:0012346)1.86343859
101Abnormal glycosylation (HP:0012345)1.86343859
102Ectopic kidney (HP:0000086)1.86108739
103Heterotopia (HP:0002282)1.85672873
104Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.84963860
105Cutis marmorata (HP:0000965)1.84863556
106Sclerocornea (HP:0000647)1.84603713
107Neonatal respiratory distress (HP:0002643)1.83927349
108Renovascular hypertension (HP:0100817)1.83315541
109Abnormality of homocysteine metabolism (HP:0010919)1.82987209
110Homocystinuria (HP:0002156)1.82987209
111Glioma (HP:0009733)1.82959396
112Abnormal number of incisors (HP:0011064)1.82470127
113Facial hemangioma (HP:0000329)1.82047479
114Hepatocellular necrosis (HP:0001404)1.81706224
115Clubbing of toes (HP:0100760)1.80287853
116Angiofibromas (HP:0010615)1.79750701
117Adenoma sebaceum (HP:0009720)1.79750701
118Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.79225992
119Aneurysm (HP:0002617)1.78993099
120Atresia of the external auditory canal (HP:0000413)1.78603325
121Abnormality of the nasal septum (HP:0000419)1.77925781
122Cafe-au-lait spot (HP:0000957)1.77875598
123Genu recurvatum (HP:0002816)1.77791694
124Aplasia/Hypoplasia involving the musculature (HP:0001460)1.77685461
125Clumsiness (HP:0002312)1.77452562
126Broad palm (HP:0001169)1.76834221
127Rib fusion (HP:0000902)1.76322237
128Uterine neoplasm (HP:0010784)1.74990614
129Abnormality of chromosome stability (HP:0003220)1.74973664
130Sandal gap (HP:0001852)1.74489578
131Hepatic necrosis (HP:0002605)1.73438438
132Neoplasm of the oral cavity (HP:0100649)1.73089501
133Patellar aplasia (HP:0006443)1.72107175
134Opisthotonus (HP:0002179)1.71436594
135Back pain (HP:0003418)1.71357741
136Missing ribs (HP:0000921)1.71216326
137Chromsome breakage (HP:0040012)1.70412912
138Cutaneous melanoma (HP:0012056)1.68640329
139Trigonocephaly (HP:0000243)1.67847077
140Abnormality of the peritoneum (HP:0002585)1.67389015
141Hypochromic microcytic anemia (HP:0004840)1.67189751
142Fibroma (HP:0010614)1.66543724
143Skull defect (HP:0001362)1.66083626
144Hypoplasia of the radius (HP:0002984)1.65893538
145Cystic liver disease (HP:0006706)1.65674102
146Abnormal platelet volume (HP:0011876)1.65379633
147Fibrous tissue neoplasm (HP:0012316)1.64477643
148Thin bony cortex (HP:0002753)1.64323075
149Increased mean platelet volume (HP:0011877)1.63388832
150Abnormality of the labia minora (HP:0012880)1.63288229
151Enlarged penis (HP:0000040)1.63207023
152Female pseudohermaphroditism (HP:0010458)1.62981467
153Intestinal polyp (HP:0005266)1.62014476
154Leiomyosarcoma (HP:0100243)1.61866143
155Uterine leiomyosarcoma (HP:0002891)1.61866143
156Persistence of primary teeth (HP:0006335)1.60641389
157Bile duct proliferation (HP:0001408)1.59858912
158Abnormal biliary tract physiology (HP:0012439)1.59858912
159Triphalangeal thumb (HP:0001199)1.59819782
160Bilateral microphthalmos (HP:0007633)1.59800158
161Hyperventilation (HP:0002883)1.59695234
162Microretrognathia (HP:0000308)1.58590083
163Mitochondrial inheritance (HP:0001427)1.58304671
164Hallux valgus (HP:0001822)1.58243792
165Abnormality of serum amino acid levels (HP:0003112)1.58069565
166Lymphangioma (HP:0100764)1.57990498
167Aplasia/Hypoplasia of the patella (HP:0006498)1.57917611
168Deep philtrum (HP:0002002)1.57911785
169Hypochromic anemia (HP:0001931)1.56834877
170Macroorchidism (HP:0000053)1.56440837
171Abnormality of the calcaneus (HP:0008364)1.56379661
172Intestinal polyposis (HP:0200008)1.55921771
173Hyperglycinuria (HP:0003108)1.55495445
174Elfin facies (HP:0004428)1.55375739
175Bowel diverticulosis (HP:0005222)1.55032823
176Short 5th finger (HP:0009237)1.54979236
177Bicuspid aortic valve (HP:0001647)1.54882783
178Deviation of the hallux (HP:0010051)1.54678814
179Horseshoe kidney (HP:0000085)1.54561832
180Bulbous nose (HP:0000414)1.54351742
181Absent epiphyses (HP:0010577)1.53948149
182Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.53948149
183Dandy-Walker malformation (HP:0001305)1.53569828
184Squamous cell carcinoma (HP:0002860)1.53370011
185Progressive muscle weakness (HP:0003323)1.53127713
186Brushfield spots (HP:0001088)1.52920529
187Acute myeloid leukemia (HP:0004808)1.52905718
188Aortic aneurysm (HP:0004942)1.52555114
189Sparse lateral eyebrow (HP:0005338)1.52210169
190Testicular atrophy (HP:0000029)1.52061400
191Blepharitis (HP:0000498)1.51737193
192Radial bowing (HP:0002986)1.50744585
193Transitional cell carcinoma of the bladder (HP:0006740)1.50668254
194Abnormality of the distal phalanx of the thumb (HP:0009617)1.50314209

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK4.57950966
2CDK124.46504393
3EEF2K4.05953118
4BMPR1B3.81631614
5TRIB33.54449018
6TLK13.26968170
7FRK3.22268762
8PKN23.19340805
9MAP3K103.12606084
10WNK42.91331873
11CDC72.89746272
12PDK22.47079107
13NEK22.30589673
14LATS12.19679034
15STK102.18044175
16ADRBK22.16957804
17SRPK12.00270399
18MKNK21.94741090
19ERN11.93557988
20MAP3K41.87949616
21MAP4K11.87166085
22MAP2K71.75795429
23RPS6KB21.75082857
24TTK1.68346791
25INSRR1.65625839
26NUAK11.64027798
27VRK11.57768139
28CDK41.56339273
29LRRK21.51723073
30VRK21.51171079
31PTK61.51075967
32STK31.46002628
33TTN1.42909550
34PASK1.39955996
35CDK61.39888437
36ALK1.36365814
37SCYL21.35234015
38PLK41.34804136
39MAP3K81.32004885
40SIK11.31750906
41RPS6KA41.30578811
42RIPK11.30269501
43MTOR1.25102563
44GRK11.24875602
45PDGFRA1.23010646
46GRK61.22960777
47OBSCN1.22468638
48TIE11.21766253
49CDK71.20792718
50NEK11.20017984
51PAK41.19012057
52PHKG11.17720076
53PHKG21.17720076
54NME11.16623659
55TGFBR11.13623853
56BRD41.11809417
57EPHA21.03124253
58FLT31.01570664
59* CHEK10.99353563
60RPS6KA50.99206495
61TSSK60.99185216
62WEE10.97566708
63LATS20.96889701
64AURKB0.95754375
65ATR0.95402832
66ICK0.94379293
67STK390.93945451
68STK40.93663990
69PLK10.90382547
70JAK30.90032362
71STK160.89534897
72BMX0.88975589
73FGFR40.88465455
74TAOK10.88026410
75CHEK20.87589875
76PIM10.86441267
77MELK0.85897997
78STK38L0.81958188
79CSF1R0.78270219
80MAP2K20.77829876
81MAPK130.76309838
82PAK20.76145471
83TAF10.76009860
84CDK90.75745395
85PAK60.75493473
86CAMK1D0.75074442
87CAMK1G0.74159300
88MAP2K30.72700649
89ATM0.72624077
90BUB10.72394227
91MAPKAPK50.71529197
92CDK20.70921954
93FGFR30.70445184
94CDK80.70152648
95ZAP700.68772352
96DMPK0.67469861
97CHUK0.67012887
98CASK0.66450078
99FGFR10.66243970
100CSNK1A1L0.63211485
101ADRBK10.63027980
102PRKCI0.62787539
103BRSK20.62573540
104PBK0.61158838
105NEK90.59855287
106WNK30.59363568
107TAOK30.58963693
108BCKDK0.58157557
109TESK20.57612000
110MAPKAPK30.57132843
111MAP2K10.56490121
112MAPK110.56290895
113MAP4K20.56251844
114TYRO30.56024516
115DYRK20.55205677
116PRKAA20.54832453
117PDGFRB0.54112536
118PRKAA10.53585739
119PAK30.52236343
120AKT20.52056389
121TNIK0.51713661
122HIPK20.51706737
123BTK0.51638553
124PTK20.50522012
125MAP2K40.50507609
126MAP3K70.50163619
127DAPK20.49538190
128PIM20.49144840
129ITK0.48593051
130MUSK0.48326525
131ILK0.48305724
132CSNK1G10.47976414
133CSNK1E0.47702150
134CDK10.45940584
135TGFBR20.45345407
136CAMK40.45119106
137CSNK1D0.44691116
138CSNK1G30.44513440
139DYRK30.44290684
140MAPK150.44259886
141TYK20.43710458
142OXSR10.43609865
143ERBB40.43131673
144RAF10.42268553
145MKNK10.41940274
146AKT30.41624475
147KDR0.40049416
148RPS6KA10.39618282
149PLK30.38233162
150PRKDC0.37808654
151JAK20.37382691
152CCNB10.37373994
153ACVR1B0.37212213
154MAPK10.36347553
155AURKA0.35144905
156RET0.34810145
157AKT10.34596319
158MAPK140.34227959
159CSK0.33905773
160EIF2AK10.33558221
161MAPKAPK20.33035610

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.60967233
2RNA polymerase_Homo sapiens_hsa030203.01949903
3DNA replication_Homo sapiens_hsa030302.88788571
4One carbon pool by folate_Homo sapiens_hsa006702.63920437
5Cell cycle_Homo sapiens_hsa041102.42834950
6RNA transport_Homo sapiens_hsa030132.33333467
7Mismatch repair_Homo sapiens_hsa034302.29921788
8Basal transcription factors_Homo sapiens_hsa030222.15778771
9Spliceosome_Homo sapiens_hsa030402.05721696
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.93803764
11Base excision repair_Homo sapiens_hsa034101.86894275
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.81577932
13Pyrimidine metabolism_Homo sapiens_hsa002401.81183420
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.76659199
15Lysine degradation_Homo sapiens_hsa003101.75336715
16mRNA surveillance pathway_Homo sapiens_hsa030151.74844488
17Chronic myeloid leukemia_Homo sapiens_hsa052201.74168967
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.64503348
19Phototransduction_Homo sapiens_hsa047441.61903588
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.60236808
21Small cell lung cancer_Homo sapiens_hsa052221.53559216
22p53 signaling pathway_Homo sapiens_hsa041151.52491762
23Butanoate metabolism_Homo sapiens_hsa006501.52384681
24MicroRNAs in cancer_Homo sapiens_hsa052061.51503159
25Viral carcinogenesis_Homo sapiens_hsa052031.41450570
26Purine metabolism_Homo sapiens_hsa002301.40826102
27mTOR signaling pathway_Homo sapiens_hsa041501.37971946
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.34811998
29HTLV-I infection_Homo sapiens_hsa051661.33844118
30Nucleotide excision repair_Homo sapiens_hsa034201.31515304
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.31231244
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.30160337
33Adherens junction_Homo sapiens_hsa045201.29603964
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29259883
35Notch signaling pathway_Homo sapiens_hsa043301.29012229
36RNA degradation_Homo sapiens_hsa030181.28220409
37Pancreatic cancer_Homo sapiens_hsa052121.28057860
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28004471
39Antigen processing and presentation_Homo sapiens_hsa046121.27945849
40Selenocompound metabolism_Homo sapiens_hsa004501.26989008
41Bladder cancer_Homo sapiens_hsa052191.22542746
42Thyroid cancer_Homo sapiens_hsa052161.21318539
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18357919
44Colorectal cancer_Homo sapiens_hsa052101.16894806
45Proteasome_Homo sapiens_hsa030501.15763553
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.13815384
47Acute myeloid leukemia_Homo sapiens_hsa052211.13658927
48Tryptophan metabolism_Homo sapiens_hsa003801.12466936
49Non-small cell lung cancer_Homo sapiens_hsa052231.11812052
50Biosynthesis of amino acids_Homo sapiens_hsa012301.11442818
51Homologous recombination_Homo sapiens_hsa034401.10322000
52Herpes simplex infection_Homo sapiens_hsa051681.09503462
53Primary immunodeficiency_Homo sapiens_hsa053401.08843432
54Central carbon metabolism in cancer_Homo sapiens_hsa052301.06896238
55Proteoglycans in cancer_Homo sapiens_hsa052051.06155703
56Pyruvate metabolism_Homo sapiens_hsa006201.06111059
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05346125
58Systemic lupus erythematosus_Homo sapiens_hsa053221.04856375
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.04831017
60Viral myocarditis_Homo sapiens_hsa054161.04817624
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00538738
62Nitrogen metabolism_Homo sapiens_hsa009101.00096127
63Oxidative phosphorylation_Homo sapiens_hsa001900.99982723
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.99806831
65Basal cell carcinoma_Homo sapiens_hsa052170.99231469
66Hippo signaling pathway_Homo sapiens_hsa043900.99119009
67Propanoate metabolism_Homo sapiens_hsa006400.97981358
68Fanconi anemia pathway_Homo sapiens_hsa034600.97575267
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96503694
70Hepatitis B_Homo sapiens_hsa051610.95877733
71Non-homologous end-joining_Homo sapiens_hsa034500.95076577
72Parkinsons disease_Homo sapiens_hsa050120.94953075
73Endometrial cancer_Homo sapiens_hsa052130.94383055
74B cell receptor signaling pathway_Homo sapiens_hsa046620.94182938
75Huntingtons disease_Homo sapiens_hsa050160.93025493
76Apoptosis_Homo sapiens_hsa042100.90873237
77Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89208000
78ABC transporters_Homo sapiens_hsa020100.87364072
79Steroid biosynthesis_Homo sapiens_hsa001000.86104074
80Peroxisome_Homo sapiens_hsa041460.85685572
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.83542628
82TGF-beta signaling pathway_Homo sapiens_hsa043500.82418574
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82180748
84NF-kappa B signaling pathway_Homo sapiens_hsa040640.79612482
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79213961
86Toxoplasmosis_Homo sapiens_hsa051450.78473163
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78383525
88Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.78286174
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78135201
90Insulin resistance_Homo sapiens_hsa049310.77941258
91Focal adhesion_Homo sapiens_hsa045100.77555435
92Prostate cancer_Homo sapiens_hsa052150.77430394
93Epstein-Barr virus infection_Homo sapiens_hsa051690.77060431
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.76706639
95T cell receptor signaling pathway_Homo sapiens_hsa046600.75944731
96Linoleic acid metabolism_Homo sapiens_hsa005910.74866883
97Measles_Homo sapiens_hsa051620.74733709
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74036533
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73309295
100Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72394090
1012-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.71704194
102Primary bile acid biosynthesis_Homo sapiens_hsa001200.71632645
103Metabolic pathways_Homo sapiens_hsa011000.71563209
104Pentose phosphate pathway_Homo sapiens_hsa000300.70836885
105Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.68490321
106Pathways in cancer_Homo sapiens_hsa052000.67575206
107Cyanoamino acid metabolism_Homo sapiens_hsa004600.67069732
108Shigellosis_Homo sapiens_hsa051310.66330393
109Ribosome_Homo sapiens_hsa030100.65776956
110Maturity onset diabetes of the young_Homo sapiens_hsa049500.65660168
111HIF-1 signaling pathway_Homo sapiens_hsa040660.64858114
112AMPK signaling pathway_Homo sapiens_hsa041520.64426554
113Arginine and proline metabolism_Homo sapiens_hsa003300.64023909
114Legionellosis_Homo sapiens_hsa051340.63183539
115Carbon metabolism_Homo sapiens_hsa012000.62825747
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62805924
117Protein export_Homo sapiens_hsa030600.61970665
118VEGF signaling pathway_Homo sapiens_hsa043700.60663495
119Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60627607
120Leishmaniasis_Homo sapiens_hsa051400.60452675
121Renal cell carcinoma_Homo sapiens_hsa052110.60278651
122N-Glycan biosynthesis_Homo sapiens_hsa005100.59796194
123FoxO signaling pathway_Homo sapiens_hsa040680.59525886
124Prolactin signaling pathway_Homo sapiens_hsa049170.59381846
125Neurotrophin signaling pathway_Homo sapiens_hsa047220.59185222
126Cysteine and methionine metabolism_Homo sapiens_hsa002700.59129540
127Jak-STAT signaling pathway_Homo sapiens_hsa046300.55839281
128Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53134970
129Glycerolipid metabolism_Homo sapiens_hsa005610.52154232
130Osteoclast differentiation_Homo sapiens_hsa043800.51590498
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51430688
132Arginine biosynthesis_Homo sapiens_hsa002200.50157037
133Sulfur relay system_Homo sapiens_hsa041220.49341182
134Insulin signaling pathway_Homo sapiens_hsa049100.48331487
135Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.47583459
136Hematopoietic cell lineage_Homo sapiens_hsa046400.47089457
137Alcoholism_Homo sapiens_hsa050340.46941427
138Glioma_Homo sapiens_hsa052140.46815288
139Oocyte meiosis_Homo sapiens_hsa041140.46058792
140Influenza A_Homo sapiens_hsa051640.45932372
141Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45372227
142Drug metabolism - other enzymes_Homo sapiens_hsa009830.45178844
143Fatty acid degradation_Homo sapiens_hsa000710.43982685
144Alzheimers disease_Homo sapiens_hsa050100.41727787
145Steroid hormone biosynthesis_Homo sapiens_hsa001400.40953225
146beta-Alanine metabolism_Homo sapiens_hsa004100.39137076
147Fructose and mannose metabolism_Homo sapiens_hsa000510.38320746
148Fatty acid metabolism_Homo sapiens_hsa012120.37202647
149Fat digestion and absorption_Homo sapiens_hsa049750.35960287
150Taste transduction_Homo sapiens_hsa047420.35491338
151Vitamin digestion and absorption_Homo sapiens_hsa049770.35180593
152Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.32968778
153Cardiac muscle contraction_Homo sapiens_hsa042600.28671530
154Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28488053
155Hedgehog signaling pathway_Homo sapiens_hsa043400.27997008
156Ovarian steroidogenesis_Homo sapiens_hsa049130.27807256
157Chemical carcinogenesis_Homo sapiens_hsa052040.27566329
158Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.27291474
159Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.26046787
160Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.25080699
161Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24436027
162Ether lipid metabolism_Homo sapiens_hsa005650.24356548

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