

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | nuclear pore complex assembly (GO:0051292) | 4.81721499 |
| 2 | nuclear pore organization (GO:0006999) | 4.79690832 |
| 3 | fusion of sperm to egg plasma membrane (GO:0007342) | 4.44141884 |
| 4 | sperm-egg recognition (GO:0035036) | 4.33501679 |
| 5 | binding of sperm to zona pellucida (GO:0007339) | 4.23611193 |
| 6 | mitotic metaphase plate congression (GO:0007080) | 4.23162850 |
| 7 | DNA replication-dependent nucleosome organization (GO:0034723) | 4.22343559 |
| 8 | DNA replication-dependent nucleosome assembly (GO:0006335) | 4.22343559 |
| 9 | DNA replication initiation (GO:0006270) | 4.16124007 |
| 10 | protein localization to chromosome, centromeric region (GO:0071459) | 4.12614380 |
| 11 | DNA synthesis involved in DNA repair (GO:0000731) | 4.11832003 |
| 12 | protein localization to kinetochore (GO:0034501) | 4.06574288 |
| 13 | mitotic nuclear envelope disassembly (GO:0007077) | 4.00653448 |
| 14 | cell wall macromolecule metabolic process (GO:0044036) | 4.00647762 |
| 15 | cell wall macromolecule catabolic process (GO:0016998) | 4.00647762 |
| 16 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.98713067 |
| 17 | synaptonemal complex assembly (GO:0007130) | 3.93975634 |
| 18 | purine nucleobase biosynthetic process (GO:0009113) | 3.90483775 |
| 19 | DNA replication checkpoint (GO:0000076) | 3.87364912 |
| 20 | nucleobase biosynthetic process (GO:0046112) | 3.86524647 |
| 21 | cell-cell recognition (GO:0009988) | 3.86417662 |
| 22 | piRNA metabolic process (GO:0034587) | 3.83694974 |
| 23 | establishment of integrated proviral latency (GO:0075713) | 3.82438649 |
| 24 | microtubule depolymerization (GO:0007019) | 3.80585121 |
| 25 | DNA strand elongation (GO:0022616) | 3.78382073 |
| 26 | pore complex assembly (GO:0046931) | 3.78362608 |
| 27 | regulation of DNA endoreduplication (GO:0032875) | 3.74271393 |
| 28 | cilium or flagellum-dependent cell motility (GO:0001539) | 3.74198695 |
| 29 | chromatin remodeling at centromere (GO:0031055) | 3.73069749 |
| 30 | histone exchange (GO:0043486) | 3.72970629 |
| 31 | DNA unwinding involved in DNA replication (GO:0006268) | 3.72434247 |
| 32 | nuclear envelope disassembly (GO:0051081) | 3.71266253 |
| 33 | membrane disassembly (GO:0030397) | 3.71266253 |
| 34 | ribosome biogenesis (GO:0042254) | 3.68999866 |
| 35 | acrosome assembly (GO:0001675) | 3.68986021 |
| 36 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.68827158 |
| 37 | synapsis (GO:0007129) | 3.65738180 |
| 38 | synaptonemal complex organization (GO:0070193) | 3.65305961 |
| 39 | metaphase plate congression (GO:0051310) | 3.62247360 |
| 40 | male meiosis (GO:0007140) | 3.59760401 |
| 41 | CENP-A containing nucleosome assembly (GO:0034080) | 3.56764171 |
| 42 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.56730366 |
| 43 | ribosome assembly (GO:0042255) | 3.56522136 |
| 44 | mitotic chromosome condensation (GO:0007076) | 3.55133025 |
| 45 | sister chromatid cohesion (GO:0007062) | 3.53898498 |
| 46 | mitotic sister chromatid segregation (GO:0000070) | 3.51772231 |
| 47 | sperm motility (GO:0030317) | 3.49497251 |
| 48 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.49063092 |
| 49 | DNA replication-independent nucleosome organization (GO:0034724) | 3.49063092 |
| 50 | kinetochore organization (GO:0051383) | 3.47380434 |
| 51 | regulation of centriole replication (GO:0046599) | 3.44657130 |
| 52 | regulation of spindle organization (GO:0090224) | 3.43469509 |
| 53 | regulation of sister chromatid cohesion (GO:0007063) | 3.42951058 |
| 54 | multicellular organism reproduction (GO:0032504) | 3.41165603 |
| 55 | mitotic sister chromatid cohesion (GO:0007064) | 3.40132223 |
| 56 | regulation of histone H3-K9 methylation (GO:0051570) | 3.39507738 |
| 57 | regulation of chromosome segregation (GO:0051983) | 3.38667622 |
| 58 | regulation of centrosome cycle (GO:0046605) | 3.38417742 |
| 59 | formation of translation preinitiation complex (GO:0001731) | 3.37832969 |
| 60 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.35881698 |
| 61 | spermatid development (GO:0007286) | 3.35104176 |
| 62 | monoubiquitinated protein deubiquitination (GO:0035520) | 3.34159913 |
| 63 | regulation of centrosome duplication (GO:0010824) | 3.33428114 |
| 64 | telomere maintenance via recombination (GO:0000722) | 3.32889550 |
| 65 | non-recombinational repair (GO:0000726) | 3.32360040 |
| 66 | double-strand break repair via nonhomologous end joining (GO:0006303) | 3.32360040 |
| 67 | chromosome organization involved in meiosis (GO:0070192) | 3.31797234 |
| 68 | DNA conformation change (GO:0071103) | 3.31748436 |
| 69 | protein K6-linked ubiquitination (GO:0085020) | 3.31288465 |
| 70 | chromosome condensation (GO:0030261) | 3.29646415 |
| 71 | positive regulation of chromosome segregation (GO:0051984) | 3.28226285 |
| 72 | axonemal dynein complex assembly (GO:0070286) | 3.27330565 |
| 73 | chaperone-mediated protein complex assembly (GO:0051131) | 3.27045314 |
| 74 | DNA deamination (GO:0045006) | 3.26480980 |
| 75 | rRNA methylation (GO:0031167) | 3.24874029 |
| 76 | mitotic spindle checkpoint (GO:0071174) | 3.24785973 |
| 77 | centriole replication (GO:0007099) | 3.24764055 |
| 78 | IMP biosynthetic process (GO:0006188) | 3.24368443 |
| 79 | maturation of SSU-rRNA (GO:0030490) | 3.23287221 |
| 80 | DNA packaging (GO:0006323) | 3.23028241 |
| 81 | mitotic recombination (GO:0006312) | 3.22842262 |
| 82 | meiotic chromosome segregation (GO:0045132) | 3.22651076 |
| 83 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.22119322 |
| 84 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.22119322 |
| 85 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.21864280 |
| 86 | sister chromatid segregation (GO:0000819) | 3.21559124 |
| 87 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 3.21447305 |
| 88 | mitotic spindle assembly checkpoint (GO:0007094) | 3.20855923 |
| 89 | establishment of chromosome localization (GO:0051303) | 3.20147673 |
| 90 | rRNA modification (GO:0000154) | 3.18966798 |
| 91 | centriole assembly (GO:0098534) | 3.18214740 |
| 92 | negative regulation of chromosome segregation (GO:0051985) | 3.17546582 |
| 93 | nuclear envelope organization (GO:0006998) | 3.16860140 |
| 94 | plasma membrane fusion (GO:0045026) | 3.16757499 |
| 95 | DNA ligation (GO:0006266) | 3.16255439 |
| 96 | meiotic nuclear division (GO:0007126) | 3.14382913 |
| 97 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 3.13397589 |
| 98 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 3.13397589 |
| 99 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 3.13397589 |
| 100 | negative regulation of sister chromatid segregation (GO:0033046) | 3.13397589 |
| 101 | motile cilium assembly (GO:0044458) | 3.12462703 |
| 102 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 3.10319635 |
| 103 | kinetochore assembly (GO:0051382) | 3.10241341 |
| 104 | regulation of helicase activity (GO:0051095) | 3.10151952 |
| 105 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.09378255 |
| 106 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.08460496 |
| 107 | protein localization to chromosome (GO:0034502) | 3.07711720 |
| 108 | spindle checkpoint (GO:0031577) | 3.06372679 |
| 109 | DNA topological change (GO:0006265) | 3.06135607 |
| 110 | regulation of spindle checkpoint (GO:0090231) | 3.04076509 |
| 111 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 3.03050104 |
| 112 | chromatin assembly or disassembly (GO:0006333) | 3.02514967 |
| 113 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 3.02393805 |
| 114 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.01175186 |
| 115 | termination of RNA polymerase II transcription (GO:0006369) | 3.00772023 |
| 116 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.00599398 |
| 117 | negative regulation of mRNA processing (GO:0050686) | 3.00234079 |
| 118 | negative regulation of RNA splicing (GO:0033119) | 2.99636322 |
| 119 | ATP-dependent chromatin remodeling (GO:0043044) | 2.97872562 |
| 120 | chromosome segregation (GO:0007059) | 2.97586097 |
| 121 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 2.97427888 |
| 122 | DNA geometric change (GO:0032392) | 2.97399107 |
| 123 | DNA duplex unwinding (GO:0032508) | 2.96799504 |
| 124 | DNA double-strand break processing (GO:0000729) | 2.96648992 |
| 125 | mitotic G2/M transition checkpoint (GO:0044818) | 2.96147495 |
| 126 | spindle assembly checkpoint (GO:0071173) | 2.95974292 |
| 127 | regulation of sister chromatid segregation (GO:0033045) | 2.94993987 |
| 128 | regulation of mitotic sister chromatid separation (GO:0010965) | 2.94993987 |
| 129 | regulation of mitotic sister chromatid segregation (GO:0033047) | 2.94993987 |
| 130 | positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101) | 2.94779513 |
| 131 | positive regulation of mitotic sister chromatid separation (GO:1901970) | 2.94779513 |
| 132 | mitochondrial RNA metabolic process (GO:0000959) | 2.93887826 |
| 133 | establishment of viral latency (GO:0019043) | 2.89840413 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 8.66019966 |
| 2 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 5.04404271 |
| 3 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 4.49247929 |
| 4 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.99415891 |
| 5 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.93920468 |
| 6 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 3.27255312 |
| 7 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.84189600 |
| 8 | * MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.82833973 |
| 9 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.73380923 |
| 10 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.64908532 |
| 11 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.59835742 |
| 12 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.56527666 |
| 13 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.45853133 |
| 14 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.43255963 |
| 15 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.30755001 |
| 16 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.30104993 |
| 17 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.29654804 |
| 18 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.22337796 |
| 19 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 2.17870403 |
| 20 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.10928159 |
| 21 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.08692713 |
| 22 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.08024798 |
| 23 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 2.05449858 |
| 24 | * MYCN_18555785_ChIP-Seq_MESCs_Mouse | 2.03332320 |
| 25 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.02281843 |
| 26 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.98148403 |
| 27 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.82771940 |
| 28 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.80875339 |
| 29 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.75799899 |
| 30 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.74779856 |
| 31 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.74548103 |
| 32 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.73436920 |
| 33 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.69746894 |
| 34 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.69365762 |
| 35 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.68776540 |
| 36 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.68422157 |
| 37 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.64116921 |
| 38 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.64107282 |
| 39 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.62734769 |
| 40 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.61516632 |
| 41 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.61391865 |
| 42 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.59758992 |
| 43 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.57779289 |
| 44 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.55469874 |
| 45 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.48942517 |
| 46 | FUS_26573619_Chip-Seq_HEK293_Human | 1.48213393 |
| 47 | * KDM5A_27292631_Chip-Seq_BREAST_Human | 1.47024731 |
| 48 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.43052084 |
| 49 | * ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.40616357 |
| 50 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.40472321 |
| 51 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.40180671 |
| 52 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.39062657 |
| 53 | EWS_26573619_Chip-Seq_HEK293_Human | 1.38027371 |
| 54 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.37865538 |
| 55 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.35015734 |
| 56 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.33492222 |
| 57 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.31246744 |
| 58 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.30608489 |
| 59 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.28999553 |
| 60 | * SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.28051994 |
| 61 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.27266421 |
| 62 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.24928510 |
| 63 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.24531734 |
| 64 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.23019116 |
| 65 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.22752573 |
| 66 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.22444346 |
| 67 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.17226255 |
| 68 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.16293152 |
| 69 | MYC_22102868_ChIP-Seq_BL_Human | 1.15231854 |
| 70 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.09870102 |
| 71 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 1.09635732 |
| 72 | * DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.08210809 |
| 73 | * E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.07523864 |
| 74 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.06841079 |
| 75 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.05469903 |
| 76 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.04120910 |
| 77 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.00296868 |
| 78 | * ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.99840803 |
| 79 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 0.99351396 |
| 80 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.94750345 |
| 81 | PKCTHETA_26484144_Chip-Seq_BREAST_Human | 0.93944678 |
| 82 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.93768253 |
| 83 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.92493767 |
| 84 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 0.92109194 |
| 85 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 0.92109194 |
| 86 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 0.92109194 |
| 87 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 0.91971588 |
| 88 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.91481827 |
| 89 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.91073994 |
| 90 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 0.90040217 |
| 91 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.89574352 |
| 92 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.89178999 |
| 93 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.87739011 |
| 94 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.86824644 |
| 95 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.86362162 |
| 96 | * NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.86333163 |
| 97 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.85185021 |
| 98 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.83519922 |
| 99 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.82646394 |
| 100 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.82289813 |
| 101 | * CHD1_26751641_Chip-Seq_LNCaP_Human | 0.81072234 |
| 102 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.80819389 |
| 103 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.80184314 |
| 104 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.80017060 |
| 105 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.79861054 |
| 106 | * TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 0.79708880 |
| 107 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 0.79400393 |
| 108 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.79090082 |
| 109 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.78827152 |
| 110 | * CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.77613237 |
| 111 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.77353104 |
| 112 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.75901774 |
| 113 | POU5F1_18692474_ChIP-Seq_MESCs_Mouse | 0.73271134 |
| 114 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.73001913 |
| 115 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.72381279 |
| 116 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 0.72367067 |
| 117 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.70518315 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.10899240 |
| 2 | MP0003111_abnormal_nucleus_morphology | 4.50768182 |
| 3 | MP0010094_abnormal_chromosome_stability | 4.50137429 |
| 4 | MP0005410_abnormal_fertilization | 4.35474218 |
| 5 | MP0008057_abnormal_DNA_replication | 4.15575421 |
| 6 | MP0004957_abnormal_blastocyst_morpholog | 3.92731130 |
| 7 | MP0003077_abnormal_cell_cycle | 3.83027359 |
| 8 | MP0008877_abnormal_DNA_methylation | 3.72116416 |
| 9 | MP0008058_abnormal_DNA_repair | 3.54055983 |
| 10 | MP0008007_abnormal_cellular_replicative | 2.78826328 |
| 11 | MP0001929_abnormal_gametogenesis | 2.66736772 |
| 12 | MP0002210_abnormal_sex_determination | 2.40517584 |
| 13 | MP0001730_embryonic_growth_arrest | 2.38806848 |
| 14 | MP0008932_abnormal_embryonic_tissue | 2.36229952 |
| 15 | MP0003698_abnormal_male_reproductive | 2.30729736 |
| 16 | MP0010307_abnormal_tumor_latency | 2.20609118 |
| 17 | MP0009697_abnormal_copulation | 2.13310615 |
| 18 | MP0000350_abnormal_cell_proliferation | 2.10540310 |
| 19 | MP0003123_paternal_imprinting | 2.10038102 |
| 20 | MP0001145_abnormal_male_reproductive | 2.08728340 |
| 21 | MP0003786_premature_aging | 2.04861498 |
| 22 | MP0010352_gastrointestinal_tract_polyps | 1.85472105 |
| 23 | MP0001672_abnormal_embryogenesis/_devel | 1.85330473 |
| 24 | MP0005380_embryogenesis_phenotype | 1.85330473 |
| 25 | MP0002653_abnormal_ependyma_morphology | 1.80712568 |
| 26 | * MP0000653_abnormal_sex_gland | 1.75249560 |
| 27 | MP0001697_abnormal_embryo_size | 1.70207808 |
| 28 | MP0003984_embryonic_growth_retardation | 1.65191328 |
| 29 | MP0002009_preneoplasia | 1.63599654 |
| 30 | MP0002088_abnormal_embryonic_growth/wei | 1.60580927 |
| 31 | MP0002160_abnormal_reproductive_system | 1.55990396 |
| 32 | MP0002085_abnormal_embryonic_tissue | 1.55947346 |
| 33 | MP0003718_maternal_effect | 1.53913052 |
| 34 | MP0002396_abnormal_hematopoietic_system | 1.53476219 |
| 35 | * MP0002080_prenatal_lethality | 1.52625591 |
| 36 | MP0002084_abnormal_developmental_patter | 1.51904469 |
| 37 | MP0003890_abnormal_embryonic-extraembry | 1.51810665 |
| 38 | MP0008789_abnormal_olfactory_epithelium | 1.50796872 |
| 39 | MP0006035_abnormal_mitochondrial_morpho | 1.50758108 |
| 40 | MP0003221_abnormal_cardiomyocyte_apopto | 1.47966349 |
| 41 | MP0001293_anophthalmia | 1.46707081 |
| 42 | MP0004197_abnormal_fetal_growth/weight/ | 1.45018844 |
| 43 | MP0002161_abnormal_fertility/fecundity | 1.43608231 |
| 44 | MP0000313_abnormal_cell_death | 1.40809830 |
| 45 | MP0002086_abnormal_extraembryonic_tissu | 1.39275901 |
| 46 | MP0000490_abnormal_crypts_of | 1.36558872 |
| 47 | MP0005367_renal/urinary_system_phenotyp | 1.34470117 |
| 48 | MP0000516_abnormal_urinary_system | 1.34470117 |
| 49 | MP0001529_abnormal_vocalization | 1.26863530 |
| 50 | MP0004808_abnormal_hematopoietic_stem | 1.25649913 |
| 51 | MP0005076_abnormal_cell_differentiation | 1.25168510 |
| 52 | MP0002019_abnormal_tumor_incidence | 1.24645391 |
| 53 | MP0005389_reproductive_system_phenotype | 1.11941497 |
| 54 | MP0002163_abnormal_gland_morphology | 1.11627500 |
| 55 | MP0003806_abnormal_nucleotide_metabolis | 1.09187193 |
| 56 | MP0006292_abnormal_olfactory_placode | 1.06226841 |
| 57 | MP0003121_genomic_imprinting | 1.05602237 |
| 58 | MP0003119_abnormal_digestive_system | 1.04880119 |
| 59 | MP0005499_abnormal_olfactory_system | 1.04480553 |
| 60 | MP0005394_taste/olfaction_phenotype | 1.04480553 |
| 61 | MP0003567_abnormal_fetal_cardiomyocyte | 1.02519139 |
| 62 | MP0005397_hematopoietic_system_phenotyp | 1.01920156 |
| 63 | MP0001545_abnormal_hematopoietic_system | 1.01920156 |
| 64 | MP0003385_abnormal_body_wall | 0.97221311 |
| 65 | MP0000358_abnormal_cell_content/ | 0.94093237 |
| 66 | MP0004185_abnormal_adipocyte_glucose | 0.94076446 |
| 67 | MP0002233_abnormal_nose_morphology | 0.91591345 |
| 68 | MP0001849_ear_inflammation | 0.90887012 |
| 69 | * MP0001119_abnormal_female_reproductive | 0.89341071 |
| 70 | MP0008995_early_reproductive_senescence | 0.88266905 |
| 71 | MP0009333_abnormal_splenocyte_physiolog | 0.88111420 |
| 72 | MP0004133_heterotaxia | 0.87688531 |
| 73 | MP0003315_abnormal_perineum_morphology | 0.85187968 |
| 74 | MP0009703_decreased_birth_body | 0.84141193 |
| 75 | MP0009053_abnormal_anal_canal | 0.83763745 |
| 76 | MP0003763_abnormal_thymus_physiology | 0.82117041 |
| 77 | MP0009672_abnormal_birth_weight | 0.81860663 |
| 78 | MP0000703_abnormal_thymus_morphology | 0.81411842 |
| 79 | MP0002132_abnormal_respiratory_system | 0.79279776 |
| 80 | MP0002092_abnormal_eye_morphology | 0.78642123 |
| 81 | MP0003828_pulmonary_edema | 0.77774927 |
| 82 | MP0005379_endocrine/exocrine_gland_phen | 0.77282926 |
| 83 | MP0005384_cellular_phenotype | 0.74662752 |
| 84 | MP0000537_abnormal_urethra_morphology | 0.73003914 |
| 85 | MP0003937_abnormal_limbs/digits/tail_de | 0.72395037 |
| 86 | MP0002398_abnormal_bone_marrow | 0.69976428 |
| 87 | MP0001661_extended_life_span | 0.69969310 |
| 88 | MP0005621_abnormal_cell_physiology | 0.68088977 |
| 89 | MP0000569_abnormal_digit_pigmentation | 0.67696535 |
| 90 | MP0003941_abnormal_skin_development | 0.67299032 |
| 91 | MP0005391_vision/eye_phenotype | 0.66788383 |
| 92 | MP0000689_abnormal_spleen_morphology | 0.66635182 |
| 93 | MP0001346_abnormal_lacrimal_gland | 0.66478652 |
| 94 | MP0002234_abnormal_pharynx_morphology | 0.66220616 |
| 95 | MP0002722_abnormal_immune_system | 0.66033648 |
| 96 | MP0000049_abnormal_middle_ear | 0.64907991 |
| 97 | MP0001286_abnormal_eye_development | 0.64688396 |
| 98 | MP0001915_intracranial_hemorrhage | 0.64044295 |
| 99 | MP0000432_abnormal_head_morphology | 0.63086923 |
| 100 | * MP0003699_abnormal_female_reproductive | 0.63072074 |
| 101 | MP0008260_abnormal_autophagy | 0.62480481 |
| 102 | MP0010234_abnormal_vibrissa_follicle | 0.62275930 |
| 103 | MP0005395_other_phenotype | 0.62272301 |
| 104 | MP0001919_abnormal_reproductive_system | 0.62065807 |
| 105 | MP0008770_decreased_survivor_rate | 0.60910461 |
| 106 | MP0002697_abnormal_eye_size | 0.60551525 |
| 107 | MP0005623_abnormal_meninges_morphology | 0.60490688 |
| 108 | MP0010030_abnormal_orbit_morphology | 0.60101069 |
| 109 | MP0002111_abnormal_tail_morphology | 0.59261362 |
| 110 | MP0003943_abnormal_hepatobiliary_system | 0.58675138 |
| 111 | MP0002102_abnormal_ear_morphology | 0.58281480 |
| 112 | MP0000858_altered_metastatic_potential | 0.58030252 |
| 113 | MP0005501_abnormal_skin_physiology | 0.57717281 |
| 114 | MP0003115_abnormal_respiratory_system | 0.57139209 |
| 115 | MP0002081_perinatal_lethality | 0.54107686 |
| 116 | MP0000428_abnormal_craniofacial_morphol | 0.53254785 |
| 117 | MP0000371_diluted_coat_color | 0.53208774 |
| 118 | MP0004264_abnormal_extraembryonic_tissu | 0.52472516 |
| 119 | MP0004233_abnormal_muscle_weight | 0.51124525 |
| 120 | MP0003936_abnormal_reproductive_system | 0.51061631 |
| 121 | MP0002429_abnormal_blood_cell | 0.50446465 |
| 122 | MP0003861_abnormal_nervous_system | 0.50302135 |
| 123 | MP0009278_abnormal_bone_marrow | 0.48870725 |
| 124 | MP0003878_abnormal_ear_physiology | 0.47770646 |
| 125 | MP0005377_hearing/vestibular/ear_phenot | 0.47770646 |
| 126 | MP0000733_abnormal_muscle_development | 0.47598327 |
| 127 | MP0002075_abnormal_coat/hair_pigmentati | 0.47009785 |
| 128 | MP0003935_abnormal_craniofacial_develop | 0.44998149 |
| 129 | MP0001727_abnormal_embryo_implantation | 0.44886651 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 5.69846442 |
| 2 | Absent/shortened dynein arms (HP:0200106) | 4.80118027 |
| 3 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 4.80118027 |
| 4 | Volvulus (HP:0002580) | 4.39055055 |
| 5 | Birth length less than 3rd percentile (HP:0003561) | 4.31746573 |
| 6 | Impulsivity (HP:0100710) | 3.92786397 |
| 7 | Chromsome breakage (HP:0040012) | 3.90449181 |
| 8 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.85371359 |
| 9 | Abnormal respiratory epithelium morphology (HP:0012253) | 3.83315209 |
| 10 | Abnormal respiratory motile cilium morphology (HP:0005938) | 3.83315209 |
| 11 | Abnormal spermatogenesis (HP:0008669) | 3.71646471 |
| 12 | Chronic bronchitis (HP:0004469) | 3.69170308 |
| 13 | Abnormal respiratory motile cilium physiology (HP:0012261) | 3.61833062 |
| 14 | Breast hypoplasia (HP:0003187) | 3.57597579 |
| 15 | Tubulointerstitial nephritis (HP:0001970) | 3.29120637 |
| 16 | Selective tooth agenesis (HP:0001592) | 3.25086443 |
| 17 | Abnormality of chromosome stability (HP:0003220) | 3.22357940 |
| 18 | Embryonal renal neoplasm (HP:0011794) | 3.20903257 |
| 19 | Rhinitis (HP:0012384) | 3.20143871 |
| 20 | Meckel diverticulum (HP:0002245) | 3.16214587 |
| 21 | Abnormality of the anterior horn cell (HP:0006802) | 3.14713139 |
| 22 | Degeneration of anterior horn cells (HP:0002398) | 3.14713139 |
| 23 | Microvesicular hepatic steatosis (HP:0001414) | 3.12895085 |
| 24 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 3.09326683 |
| 25 | Abnormality of the preputium (HP:0100587) | 3.05487895 |
| 26 | Ependymoma (HP:0002888) | 3.02061383 |
| 27 | Shoulder girdle muscle weakness (HP:0003547) | 2.98883464 |
| 28 | Abnormality of the ileum (HP:0001549) | 2.98061823 |
| 29 | Carpal bone hypoplasia (HP:0001498) | 2.95537252 |
| 30 | Absent thumb (HP:0009777) | 2.81998250 |
| 31 | Patellar aplasia (HP:0006443) | 2.78263597 |
| 32 | Supernumerary spleens (HP:0009799) | 2.77601826 |
| 33 | Azoospermia (HP:0000027) | 2.76826047 |
| 34 | Abnormal ciliary motility (HP:0012262) | 2.75671795 |
| 35 | Medulloblastoma (HP:0002885) | 2.75370502 |
| 36 | Nasal polyposis (HP:0100582) | 2.72251040 |
| 37 | Duodenal stenosis (HP:0100867) | 2.71759352 |
| 38 | Small intestinal stenosis (HP:0012848) | 2.71759352 |
| 39 | Duplicated collecting system (HP:0000081) | 2.71695937 |
| 40 | Reticulocytopenia (HP:0001896) | 2.70478836 |
| 41 | Sloping forehead (HP:0000340) | 2.68010005 |
| 42 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.62946642 |
| 43 | Oral leukoplakia (HP:0002745) | 2.60334453 |
| 44 | Absent radius (HP:0003974) | 2.58922087 |
| 45 | Abnormality of the renal collecting system (HP:0004742) | 2.56854275 |
| 46 | Agnosia (HP:0010524) | 2.55017125 |
| 47 | Ectopic kidney (HP:0000086) | 2.54751189 |
| 48 | Proximal placement of thumb (HP:0009623) | 2.54312743 |
| 49 | Bronchitis (HP:0012387) | 2.53660469 |
| 50 | Myelodysplasia (HP:0002863) | 2.50679167 |
| 51 | Abnormality of the labia minora (HP:0012880) | 2.48006291 |
| 52 | Facial cleft (HP:0002006) | 2.41607370 |
| 53 | Chronic hepatic failure (HP:0100626) | 2.41225334 |
| 54 | Infertility (HP:0000789) | 2.40204345 |
| 55 | Pelvic girdle muscle weakness (HP:0003749) | 2.39512965 |
| 56 | Aplasia involving forearm bones (HP:0009822) | 2.38241744 |
| 57 | Absent forearm bone (HP:0003953) | 2.38241744 |
| 58 | Colon cancer (HP:0003003) | 2.36110607 |
| 59 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 2.33036578 |
| 60 | Rhabdomyosarcoma (HP:0002859) | 2.30835559 |
| 61 | Bronchiectasis (HP:0002110) | 2.30502658 |
| 62 | Male infertility (HP:0003251) | 2.29671794 |
| 63 | Cortical dysplasia (HP:0002539) | 2.27889141 |
| 64 | Abnormality of DNA repair (HP:0003254) | 2.27795476 |
| 65 | Deviation of the thumb (HP:0009603) | 2.27499596 |
| 66 | Short middle phalanx of the 5th finger (HP:0004220) | 2.26376872 |
| 67 | Rough bone trabeculation (HP:0100670) | 2.24522850 |
| 68 | Neoplasm of the pancreas (HP:0002894) | 2.23677479 |
| 69 | Abnormality of the duodenum (HP:0002246) | 2.23428530 |
| 70 | Bone marrow hypocellularity (HP:0005528) | 2.20641757 |
| 71 | Abnormality of the carotid arteries (HP:0005344) | 2.19347600 |
| 72 | Prominent nose (HP:0000448) | 2.19136255 |
| 73 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.18247956 |
| 74 | 11 pairs of ribs (HP:0000878) | 2.17751688 |
| 75 | Abnormality of the hip-girdle musculature (HP:0001445) | 2.16527207 |
| 76 | Abnormality of the musculature of the pelvis (HP:0001469) | 2.16527207 |
| 77 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.16368120 |
| 78 | Sensory axonal neuropathy (HP:0003390) | 2.13321532 |
| 79 | Arteriovenous malformation (HP:0100026) | 2.13060548 |
| 80 | Abnormality of the nasal mucosa (HP:0000433) | 2.09269414 |
| 81 | Progressive external ophthalmoplegia (HP:0000590) | 2.07405187 |
| 82 | Increased nuchal translucency (HP:0010880) | 2.05486519 |
| 83 | Cerebral hypomyelination (HP:0006808) | 2.04606704 |
| 84 | Abnormal lung lobation (HP:0002101) | 2.04464040 |
| 85 | Abnormality of cochlea (HP:0000375) | 2.04204539 |
| 86 | Clubbing of toes (HP:0100760) | 2.03982559 |
| 87 | Abnormal number of erythroid precursors (HP:0012131) | 2.03831479 |
| 88 | Aplasia/Hypoplasia of the earlobes (HP:0009906) | 2.03566335 |
| 89 | Squamous cell carcinoma (HP:0002860) | 2.03254530 |
| 90 | Progressive muscle weakness (HP:0003323) | 2.02008997 |
| 91 | Abnormality of the astrocytes (HP:0100707) | 2.01833709 |
| 92 | Astrocytoma (HP:0009592) | 2.01833709 |
| 93 | Embryonal neoplasm (HP:0002898) | 2.01025977 |
| 94 | Glioma (HP:0009733) | 1.98973849 |
| 95 | Obsessive-compulsive behavior (HP:0000722) | 1.97545403 |
| 96 | Tracheoesophageal fistula (HP:0002575) | 1.96715979 |
| 97 | Abnormality of abdominal situs (HP:0011620) | 1.96675693 |
| 98 | Abdominal situs inversus (HP:0003363) | 1.96675693 |
| 99 | Tongue fasciculations (HP:0001308) | 1.96413413 |
| 100 | Choanal atresia (HP:0000453) | 1.95852565 |
| 101 | High anterior hairline (HP:0009890) | 1.95785951 |
| 102 | Ureteral duplication (HP:0000073) | 1.94159151 |
| 103 | Triphalangeal thumb (HP:0001199) | 1.93979914 |
| 104 | Nephronophthisis (HP:0000090) | 1.93582836 |
| 105 | Multiple enchondromatosis (HP:0005701) | 1.92684210 |
| 106 | Aplasia/hypoplasia of the humerus (HP:0006507) | 1.92264994 |
| 107 | Horseshoe kidney (HP:0000085) | 1.92156665 |
| 108 | Basal cell carcinoma (HP:0002671) | 1.91971261 |
| 109 | Termporal pattern (HP:0011008) | 1.91620874 |
| 110 | Insidious onset (HP:0003587) | 1.91620874 |
| 111 | Atresia of the external auditory canal (HP:0000413) | 1.90373381 |
| 112 | Aplastic anemia (HP:0001915) | 1.89117258 |
| 113 | Neoplasm of the adrenal cortex (HP:0100641) | 1.88917402 |
| 114 | Nephroblastoma (Wilms tumor) (HP:0002667) | 1.88629439 |
| 115 | Premature graying of hair (HP:0002216) | 1.85710838 |
| 116 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.85347640 |
| 117 | Cafe-au-lait spot (HP:0000957) | 1.85241876 |
| 118 | Neoplasm of the colon (HP:0100273) | 1.84798365 |
| 119 | Sandal gap (HP:0001852) | 1.82523393 |
| 120 | Abnormality of the lower motor neuron (HP:0002366) | 1.81992180 |
| 121 | Recurrent sinusitis (HP:0011108) | 1.80207767 |
| 122 | Facial hemangioma (HP:0000329) | 1.79630395 |
| 123 | Short thumb (HP:0009778) | 1.78673178 |
| 124 | Cleft eyelid (HP:0000625) | 1.78453215 |
| 125 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 1.78275658 |
| 126 | Breast carcinoma (HP:0003002) | 1.77708475 |
| 127 | Abnormality of the pons (HP:0007361) | 1.77211108 |
| 128 | Recurrent bronchitis (HP:0002837) | 1.76653909 |
| 129 | Biliary tract neoplasm (HP:0100574) | 1.76024278 |
| 130 | Premature ovarian failure (HP:0008209) | 1.75907724 |
| 131 | IgM deficiency (HP:0002850) | 1.75552484 |
| 132 | Capillary hemangiomas (HP:0005306) | 1.74711397 |
| 133 | Abnormality of the fetal cardiovascular system (HP:0010948) | 1.73613654 |
| 134 | Abnormal umbilical cord blood vessels (HP:0011403) | 1.73613654 |
| 135 | Single umbilical artery (HP:0001195) | 1.73613654 |
| 136 | Esophageal atresia (HP:0002032) | 1.73305165 |
| 137 | Poikiloderma (HP:0001029) | 1.73045723 |
| 138 | Hypoplasia of the pons (HP:0012110) | 1.68784148 |
| 139 | Oligodactyly (hands) (HP:0001180) | 1.67383515 |
| 140 | Abnormality of the septum pellucidum (HP:0007375) | 1.66407469 |
| 141 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 1.66345395 |
| 142 | Deep philtrum (HP:0002002) | 1.65941558 |
| 143 | Neoplasm of striated muscle (HP:0009728) | 1.62427694 |
| 144 | Papillary thyroid carcinoma (HP:0002895) | 1.61810308 |
| 145 | Abnormal number of incisors (HP:0011064) | 1.61516020 |
| 146 | Acute myeloid leukemia (HP:0004808) | 1.61254039 |
| 147 | Syringomyelia (HP:0003396) | 1.59861140 |
| 148 | Spinal cord lesions (HP:0100561) | 1.59861140 |
| 149 | Oligodactyly (HP:0012165) | 1.55310244 |
| 150 | Aplasia/Hypoplasia of the nipples (HP:0006709) | 1.54925733 |
| 151 | Scotoma (HP:0000575) | 1.54873345 |
| 152 | Central scotoma (HP:0000603) | 1.54110837 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 4.35055302 |
| 2 | CDC7 | 4.12852402 |
| 3 | WEE1 | 4.12782691 |
| 4 | NEK2 | 3.40075030 |
| 5 | PDK4 | 3.39840124 |
| 6 | PDK3 | 3.39840124 |
| 7 | PLK4 | 2.67353569 |
| 8 | TTK | 2.62184994 |
| 9 | SRPK1 | 2.60170960 |
| 10 | EIF2AK1 | 2.36933423 |
| 11 | PDK2 | 2.25658910 |
| 12 | CDK12 | 2.23501226 |
| 13 | PLK1 | 2.01674093 |
| 14 | DYRK3 | 2.00453711 |
| 15 | ACVR1B | 1.96431877 |
| 16 | BRSK2 | 1.94213668 |
| 17 | TESK1 | 1.94016686 |
| 18 | TRIM28 | 1.86871785 |
| 19 | ATR | 1.81706001 |
| 20 | CHEK2 | 1.72320970 |
| 21 | NEK1 | 1.71921559 |
| 22 | TSSK6 | 1.63177800 |
| 23 | CDK7 | 1.61925900 |
| 24 | VRK2 | 1.56751802 |
| 25 | EPHA2 | 1.56123344 |
| 26 | AURKB | 1.55747664 |
| 27 | ZAK | 1.54232648 |
| 28 | PLK3 | 1.52264853 |
| 29 | PASK | 1.50716365 |
| 30 | MKNK1 | 1.47986479 |
| 31 | CHEK1 | 1.45730517 |
| 32 | RPS6KA4 | 1.44987238 |
| 33 | PNCK | 1.41620755 |
| 34 | ICK | 1.41209938 |
| 35 | TESK2 | 1.41094624 |
| 36 | EIF2AK3 | 1.40344252 |
| 37 | STK16 | 1.39020932 |
| 38 | ERBB4 | 1.33149480 |
| 39 | VRK1 | 1.32991254 |
| 40 | CDK4 | 1.30781994 |
| 41 | MKNK2 | 1.27625667 |
| 42 | NME2 | 1.26606947 |
| 43 | TLK1 | 1.25114569 |
| 44 | RPS6KB2 | 1.20901312 |
| 45 | BCR | 1.19746187 |
| 46 | NUAK1 | 1.18003585 |
| 47 | AURKA | 1.14837659 |
| 48 | STK38L | 1.13566302 |
| 49 | STK3 | 1.11588354 |
| 50 | TAF1 | 1.10745113 |
| 51 | MAP3K8 | 1.07957369 |
| 52 | STK24 | 1.07843715 |
| 53 | ATM | 1.06944668 |
| 54 | STK10 | 1.04498476 |
| 55 | BRSK1 | 1.01729820 |
| 56 | CCNB1 | 1.01106949 |
| 57 | SCYL2 | 1.00539044 |
| 58 | EEF2K | 1.00156817 |
| 59 | MAP4K2 | 0.99326717 |
| 60 | STK4 | 0.91994759 |
| 61 | PAK4 | 0.91882683 |
| 62 | ERBB3 | 0.91377736 |
| 63 | RAF1 | 0.90121029 |
| 64 | PLK2 | 0.89984426 |
| 65 | * CDK2 | 0.88240798 |
| 66 | CAMK1G | 0.87405360 |
| 67 | PIM1 | 0.85389655 |
| 68 | NEK6 | 0.82160333 |
| 69 | BRD4 | 0.80849885 |
| 70 | MAP3K10 | 0.79553651 |
| 71 | CDK6 | 0.78524035 |
| 72 | PRKD3 | 0.74481807 |
| 73 | INSRR | 0.73269910 |
| 74 | CDK8 | 0.70474135 |
| 75 | CDK1 | 0.68000581 |
| 76 | MELK | 0.65170096 |
| 77 | CDK3 | 0.63525452 |
| 78 | ALK | 0.62835001 |
| 79 | TGFBR1 | 0.62748926 |
| 80 | AKT3 | 0.62327303 |
| 81 | EIF2AK2 | 0.60537872 |
| 82 | CSNK1G1 | 0.60237639 |
| 83 | PAK1 | 0.60023840 |
| 84 | MAP3K4 | 0.60013674 |
| 85 | CSNK2A2 | 0.59828990 |
| 86 | CSNK2A1 | 0.59221293 |
| 87 | TNIK | 0.57963195 |
| 88 | CSNK1G3 | 0.54299893 |
| 89 | MTOR | 0.53427315 |
| 90 | BRAF | 0.48227995 |
| 91 | KSR1 | 0.47787379 |
| 92 | CDK19 | 0.45411804 |
| 93 | RPS6KA5 | 0.43693491 |
| 94 | MST4 | 0.43216063 |
| 95 | LATS1 | 0.43058293 |
| 96 | KSR2 | 0.39967452 |
| 97 | NEK9 | 0.39646184 |
| 98 | WNK3 | 0.39278100 |
| 99 | CSNK1G2 | 0.39124441 |
| 100 | PRKCI | 0.39121141 |
| 101 | CSNK1E | 0.37154870 |
| 102 | FLT3 | 0.34555973 |
| 103 | CSNK1A1L | 0.34407712 |
| 104 | CLK1 | 0.34293675 |
| 105 | PRKDC | 0.33351579 |
| 106 | LMTK2 | 0.32000297 |
| 107 | NME1 | 0.30780416 |
| 108 | MAP4K1 | 0.30589689 |
| 109 | SMG1 | 0.30312960 |
| 110 | LATS2 | 0.29805211 |
| 111 | CSNK1D | 0.29436604 |
| 112 | MAP2K7 | 0.29422433 |
| 113 | MAP2K3 | 0.27701566 |
| 114 | MARK3 | 0.26298704 |
| 115 | MAP3K5 | 0.26135696 |
| 116 | YES1 | 0.24296055 |
| 117 | DYRK1B | 0.24276783 |
| 118 | MAPKAPK3 | 0.24001737 |
| 119 | PAK2 | 0.23499685 |
| 120 | IRAK3 | 0.23386016 |
| 121 | MAPK14 | 0.23025144 |
| 122 | PBK | 0.22575145 |
| 123 | RPS6KB1 | 0.22513989 |
| 124 | ZAP70 | 0.21626923 |
| 125 | PIM2 | 0.21387973 |
| 126 | GSK3B | 0.20579824 |
| 127 | AKT2 | 0.20504568 |
| 128 | PKN2 | 0.16385103 |
| 129 | STK38 | 0.16261644 |
| 130 | MAPK1 | 0.15155442 |
| 131 | AKT1 | 0.11939581 |
| 132 | RPS6KA1 | 0.11905948 |
| 133 | CDK9 | 0.09843506 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 4.61654504 |
| 2 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 4.10162041 |
| 3 | Mismatch repair_Homo sapiens_hsa03430 | 4.01070423 |
| 4 | * RNA transport_Homo sapiens_hsa03013 | 3.46056315 |
| 5 | Spliceosome_Homo sapiens_hsa03040 | 3.27100741 |
| 6 | Homologous recombination_Homo sapiens_hsa03440 | 3.03330416 |
| 7 | RNA polymerase_Homo sapiens_hsa03020 | 2.98048494 |
| 8 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.92588081 |
| 9 | Cell cycle_Homo sapiens_hsa04110 | 2.91811332 |
| 10 | Base excision repair_Homo sapiens_hsa03410 | 2.87259257 |
| 11 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.76320966 |
| 12 | Proteasome_Homo sapiens_hsa03050 | 2.61740733 |
| 13 | Basal transcription factors_Homo sapiens_hsa03022 | 2.55583732 |
| 14 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.52505732 |
| 15 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.43246787 |
| 16 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.40438888 |
| 17 | Ribosome_Homo sapiens_hsa03010 | 2.27974020 |
| 18 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 2.19683809 |
| 19 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 2.09064533 |
| 20 | RNA degradation_Homo sapiens_hsa03018 | 2.00604518 |
| 21 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.86136380 |
| 22 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.65178036 |
| 23 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.59766304 |
| 24 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.51748067 |
| 25 | Purine metabolism_Homo sapiens_hsa00230 | 1.44984623 |
| 26 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.40611618 |
| 27 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.40121160 |
| 28 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.37482579 |
| 29 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.26908704 |
| 30 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.22053791 |
| 31 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.15304367 |
| 32 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.12772386 |
| 33 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.05825132 |
| 34 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.98316546 |
| 35 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.97228938 |
| 36 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.96154734 |
| 37 | Protein export_Homo sapiens_hsa03060 | 0.86826855 |
| 38 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.83599840 |
| 39 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.81352385 |
| 40 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.80222146 |
| 41 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.78761078 |
| 42 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.77573944 |
| 43 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.74709784 |
| 44 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.72479205 |
| 45 | HTLV-I infection_Homo sapiens_hsa05166 | 0.72456726 |
| 46 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.71727800 |
| 47 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.71322369 |
| 48 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.65896097 |
| 49 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.63865894 |
| 50 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.59477447 |
| 51 | Legionellosis_Homo sapiens_hsa05134 | 0.55463842 |
| 52 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.54579429 |
| 53 | Carbon metabolism_Homo sapiens_hsa01200 | 0.53905946 |
| 54 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.52429502 |
| 55 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.51326271 |
| 56 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.51261940 |
| 57 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.50916648 |
| 58 | Alcoholism_Homo sapiens_hsa05034 | 0.50280309 |
| 59 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.49491854 |
| 60 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.45550938 |
| 61 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.45425901 |
| 62 | Sulfur relay system_Homo sapiens_hsa04122 | 0.43604830 |
| 63 | Thyroid cancer_Homo sapiens_hsa05216 | 0.40202152 |
| 64 | Bladder cancer_Homo sapiens_hsa05219 | 0.39847574 |
| 65 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.39760626 |
| 66 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.37469255 |
| 67 | Huntingtons disease_Homo sapiens_hsa05016 | 0.37288898 |
| 68 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.37218095 |
| 69 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.37135565 |
| 70 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.35709247 |
| 71 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.34809182 |
| 72 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.34273234 |
| 73 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.34227651 |
| 74 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.33149593 |
| 75 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.33131881 |
| 76 | Melanoma_Homo sapiens_hsa05218 | 0.32298056 |
| 77 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.32273585 |
| 78 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.31830105 |
| 79 | Measles_Homo sapiens_hsa05162 | 0.31537428 |
| 80 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.31113099 |
| 81 | Apoptosis_Homo sapiens_hsa04210 | 0.30994071 |
| 82 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.30860013 |
| 83 | Influenza A_Homo sapiens_hsa05164 | 0.29543559 |
| 84 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.27374606 |
| 85 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.26835663 |
| 86 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.26068023 |
| 87 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.25749801 |
| 88 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.24820632 |
| 89 | Lysine degradation_Homo sapiens_hsa00310 | 0.24797075 |
| 90 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.23712439 |
| 91 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.23692285 |
| 92 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.22187167 |
| 93 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.21569110 |
| 94 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.21543175 |
| 95 | Metabolic pathways_Homo sapiens_hsa01100 | 0.20389388 |
| 96 | Parkinsons disease_Homo sapiens_hsa05012 | 0.19779309 |
| 97 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.19521977 |
| 98 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.19386828 |
| 99 | Colorectal cancer_Homo sapiens_hsa05210 | 0.19081866 |
| 100 | Hepatitis B_Homo sapiens_hsa05161 | 0.18702925 |
| 101 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.18563114 |
| 102 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.18433169 |
| 103 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.18067973 |
| 104 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.17013273 |
| 105 | Adherens junction_Homo sapiens_hsa04520 | 0.16791654 |
| 106 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.16062147 |
| 107 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.14842948 |
| 108 | Prostate cancer_Homo sapiens_hsa05215 | 0.14527020 |
| 109 | Pathways in cancer_Homo sapiens_hsa05200 | 0.13128653 |
| 110 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.12495612 |
| 111 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.12021442 |
| 112 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.12003863 |
| 113 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.11731872 |
| 114 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.11535530 |
| 115 | Shigellosis_Homo sapiens_hsa05131 | 0.11051636 |
| 116 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.10830175 |
| 117 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.10219707 |
| 118 | Endometrial cancer_Homo sapiens_hsa05213 | 0.10050340 |
| 119 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.10027097 |
| 120 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.08525293 |
| 121 | Circadian rhythm_Homo sapiens_hsa04710 | 0.08349840 |
| 122 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.07680551 |
| 123 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.07629079 |
| 124 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.06445733 |

