DDX23

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the U5 snRNP complex; it may facilitate conformational changes in the spliceosome during nuclear pre-mRNA splicing. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic chromosome condensation (GO:0007076)5.13656072
2nuclear pore organization (GO:0006999)4.59653109
3Golgi transport vesicle coating (GO:0048200)4.59152399
4COPI coating of Golgi vesicle (GO:0048205)4.59152399
5negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)4.45883645
6spliceosomal tri-snRNP complex assembly (GO:0000244)4.32820761
7viral transcription (GO:0019083)4.13720558
8pore complex assembly (GO:0046931)4.07878263
9RNA stabilization (GO:0043489)3.95250392
10mRNA stabilization (GO:0048255)3.95250392
11negative regulation of erythrocyte differentiation (GO:0045647)3.83248689
12translational termination (GO:0006415)3.82434765
13regulation of RNA export from nucleus (GO:0046831)3.77663866
14positive regulation of protein kinase C signaling (GO:0090037)3.66858148
15DNA synthesis involved in DNA repair (GO:0000731)3.64868646
16positive regulation of histone deacetylation (GO:0031065)3.63641281
17proline biosynthetic process (GO:0006561)3.62481591
18mitotic sister chromatid cohesion (GO:0007064)3.62046184
19heterochromatin organization (GO:0070828)3.58045460
20formation of translation preinitiation complex (GO:0001731)3.57693036
21mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.56339717
22DNA strand elongation involved in DNA replication (GO:0006271)3.51548000
23DNA topological change (GO:0006265)3.49196452
24DNA strand elongation (GO:0022616)3.44917804
25interkinetic nuclear migration (GO:0022027)3.44310438
26regulation of nucleobase-containing compound transport (GO:0032239)3.42734388
27DNA replication initiation (GO:0006270)3.38795060
28negative regulation of Ras GTPase activity (GO:0034261)3.37311473
29DNA duplex unwinding (GO:0032508)3.31035385
30metanephric tubule development (GO:0072170)3.30869168
31metanephric nephron tubule development (GO:0072234)3.30869168
32regulation of histone H3-K27 methylation (GO:0061085)3.30352542
33eyelid development in camera-type eye (GO:0061029)3.28482194
34nephron tubule formation (GO:0072079)3.27023187
35pentose-phosphate shunt (GO:0006098)3.23148106
36mitotic sister chromatid segregation (GO:0000070)3.22613317
37metanephric nephron epithelium development (GO:0072243)3.21676386
38positive regulation of Cdc42 GTPase activity (GO:0043089)3.18511836
39regulation of stem cell maintenance (GO:2000036)3.18105418
40maternal placenta development (GO:0001893)3.14884531
41nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.14876077
42establishment of apical/basal cell polarity (GO:0035089)3.11250484
43regulation of mammary gland epithelial cell proliferation (GO:0033599)3.10532163
44peptidyl-lysine dimethylation (GO:0018027)3.10102982
45regulation of chromatin binding (GO:0035561)3.09787373
46retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.09364555
47endothelium development (GO:0003158)3.08725612
48protein export from nucleus (GO:0006611)3.08096429
49sister chromatid segregation (GO:0000819)3.06171973
50DNA geometric change (GO:0032392)3.05593766
51dosage compensation (GO:0007549)3.05503599
52apoptotic process involved in morphogenesis (GO:0060561)3.03557399
53chromosome condensation (GO:0030261)3.03413331
54regulation of histone H3-K4 methylation (GO:0051569)3.02270372
55chromatin assembly (GO:0031497)3.00501080
56pattern specification involved in kidney development (GO:0061004)3.00458873
57positive thymic T cell selection (GO:0045059)3.00006529
58ribosomal small subunit biogenesis (GO:0042274)2.99667147
59mitotic nuclear envelope disassembly (GO:0007077)2.97827051
60metanephric epithelium development (GO:0072207)2.97791693
61protein-DNA complex disassembly (GO:0032986)2.95999029
62nucleosome disassembly (GO:0006337)2.95999029
63translational elongation (GO:0006414)2.95294368
64protein complex localization (GO:0031503)2.95269539
65establishment of mitotic spindle localization (GO:0040001)2.94510897
66membrane disassembly (GO:0030397)2.94380130
67nuclear envelope disassembly (GO:0051081)2.94380130
68regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.94269813
69protein localization to chromosome, centromeric region (GO:0071459)2.94112758
70activation of Rac GTPase activity (GO:0032863)2.93195882
71regulation of mRNA stability (GO:0043488)2.91886627
72DNA conformation change (GO:0071103)2.90740800
73determination of adult lifespan (GO:0008340)2.90284434
74regulation of gene silencing by miRNA (GO:0060964)2.88890206
75regulation of gene silencing by RNA (GO:0060966)2.88890206
76regulation of posttranscriptional gene silencing (GO:0060147)2.88890206
77cellular hyperosmotic response (GO:0071474)2.88489289
78cell-substrate adherens junction assembly (GO:0007045)2.88186634
79focal adhesion assembly (GO:0048041)2.88186634
80SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.87520084
81short-term memory (GO:0007614)2.86024717
82protein targeting to ER (GO:0045047)2.84948826
83nephron epithelium development (GO:0072009)2.84257830
84axis elongation (GO:0003401)2.83746119
85genitalia morphogenesis (GO:0035112)2.83628427
86translational initiation (GO:0006413)2.83591188
87regulation of glucose import in response to insulin stimulus (GO:2001273)2.81197214
88negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.79357734
89protein localization to endosome (GO:0036010)2.78241477
90cellular response to epidermal growth factor stimulus (GO:0071364)2.77834537
91cellular protein complex localization (GO:0034629)2.77759523
92NADPH regeneration (GO:0006740)2.76542294
93cotranslational protein targeting to membrane (GO:0006613)2.76390487
94negative regulation of mRNA processing (GO:0050686)2.74480789
95establishment of protein localization to endoplasmic reticulum (GO:0072599)2.73997064
96pre-miRNA processing (GO:0031054)2.72912627
97positive regulation of hormone metabolic process (GO:0032352)2.72265516
98histone H3-K36 demethylation (GO:0070544)2.72251633
99establishment of mitotic spindle orientation (GO:0000132)2.72007888
100telomere maintenance via semi-conservative replication (GO:0032201)2.70873963
101viral life cycle (GO:0019058)2.70117700
102nuclear pore complex assembly (GO:0051292)2.69982652
103positive regulation of keratinocyte differentiation (GO:0045618)2.69577220
104mannose metabolic process (GO:0006013)2.69294618
105mesenchymal to epithelial transition (GO:0060231)2.68469746
106cellular protein complex disassembly (GO:0043624)2.66980935
107regulation of RNA stability (GO:0043487)2.66689388
108peptidyl-arginine omega-N-methylation (GO:0035247)2.65877295
109folic acid-containing compound biosynthetic process (GO:0009396)2.65686933
110cell-substrate junction assembly (GO:0007044)2.65570327
111DNA packaging (GO:0006323)2.64650175
112regulation of translational fidelity (GO:0006450)2.64584390
113embryonic process involved in female pregnancy (GO:0060136)2.62743801
114regulation of mitotic spindle organization (GO:0060236)2.62680974
115protein retention in ER lumen (GO:0006621)2.62655259
116negative regulation of mRNA metabolic process (GO:1903312)2.62091697
117maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.61967428
118glucocorticoid receptor signaling pathway (GO:0042921)2.61737309
119histone H3-K9 demethylation (GO:0033169)2.61210817
120mitochondrial DNA metabolic process (GO:0032042)2.60344172
121negative regulation of RNA splicing (GO:0033119)2.59973138
122positive regulation of endothelial cell apoptotic process (GO:2000353)2.59915799
123facial nerve structural organization (GO:0021612)2.59486916
124protein complex disassembly (GO:0043241)2.59343424
125adherens junction assembly (GO:0034333)2.58850114
126nuclear envelope organization (GO:0006998)2.58602982
1273-UTR-mediated mRNA stabilization (GO:0070935)2.58549717
128regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.58388823
129postsynaptic membrane organization (GO:0001941)2.58345391
130negative regulation of granulocyte differentiation (GO:0030853)2.58154053
131negative regulation of histone methylation (GO:0031061)2.58143016
132epithelial cell differentiation involved in prostate gland development (GO:0060742)2.57798020
133intracellular estrogen receptor signaling pathway (GO:0030520)2.56749843
134regulation of sister chromatid cohesion (GO:0007063)2.55063109
135DNA unwinding involved in DNA replication (GO:0006268)2.54872605
136glucose catabolic process (GO:0006007)2.54327861
137peptidyl-threonine dephosphorylation (GO:0035970)2.53509790
138regulation of apoptotic process involved in morphogenesis (GO:1902337)2.53427330
139histone H2B ubiquitination (GO:0033523)2.51149503
140positive regulation of nuclease activity (GO:0032075)2.49773107
141response to epidermal growth factor (GO:0070849)2.47596018
142protein localization to kinetochore (GO:0034501)2.47413801
143activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.46801523
144protein localization to endoplasmic reticulum (GO:0070972)2.46582357
145regulation of histone H3-K9 methylation (GO:0051570)2.42538311
146regulation of translational termination (GO:0006449)2.42519118
147regulation of NFAT protein import into nucleus (GO:0051532)2.41854662
148ncRNA 3-end processing (GO:0043628)2.41743038
149regulation of early endosome to late endosome transport (GO:2000641)2.41591269
150regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)2.40178774
151snRNA metabolic process (GO:0016073)2.40129087
152mitotic metaphase plate congression (GO:0007080)2.39078659
153organ growth (GO:0035265)2.38988781
154trophectodermal cell differentiation (GO:0001829)2.38978403
155ribosome biogenesis (GO:0042254)2.38906192
156positive regulation of chromosome segregation (GO:0051984)2.37797495
157Leydig cell differentiation (GO:0033327)2.37475610
158establishment of integrated proviral latency (GO:0075713)2.37249285
159mRNA transport (GO:0051028)2.36633936
160mRNA transcription (GO:0009299)2.36203288
161apoptotic process involved in development (GO:1902742)2.35936658
162regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.35335265
163peptidyl-arginine methylation (GO:0018216)2.35310945
164peptidyl-arginine N-methylation (GO:0035246)2.35310945
165positive regulation of RNA splicing (GO:0033120)2.34892314
166positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.34856454
167thymic T cell selection (GO:0045061)2.29948413
168receptor catabolic process (GO:0032801)2.29450734
169melanin metabolic process (GO:0006582)2.28947111
170macromolecular complex disassembly (GO:0032984)2.27713844
171regulation of DNA endoreduplication (GO:0032875)2.25585705
172head development (GO:0060322)2.25553872
173negative regulation of cell size (GO:0045792)2.25141307
174mRNA transcription from RNA polymerase II promoter (GO:0042789)2.24650988
175positive regulation of protein deacetylation (GO:0090312)2.24152621
176nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.24054322

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.60952847
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.17380723
3MYC_22102868_ChIP-Seq_BL_Human3.60410333
4VDR_21846776_ChIP-Seq_THP-1_Human3.30613578
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.30566898
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.94172259
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.94172259
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.94172259
9* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.93837796
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.82040055
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.78705388
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.62950580
13KDM2B_26808549_Chip-Seq_DND41_Human2.58976100
14KDM2B_26808549_Chip-Seq_SUP-B15_Human2.57113979
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.55456213
16TCF7_22412390_ChIP-Seq_EML_Mouse2.51436077
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.49197319
18* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.48362140
19KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.44442301
20KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.35052919
21TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.32881372
22SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.28442022
23MAF_26560356_Chip-Seq_TH1_Human2.27702808
24KDM2B_26808549_Chip-Seq_JURKAT_Human2.21490822
25ELK3_25401928_ChIP-Seq_HUVEC_Human2.14888412
26ZFP281_27345836_Chip-Seq_ESCs_Mouse1.99721300
27SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.97785907
28SCL_19346495_ChIP-Seq_HPC-7_Human1.95717190
29LXR_22292898_ChIP-Seq_THP-1_Human1.94469304
30ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.94377370
31VDR_24763502_ChIP-Seq_THP-1_Human1.94149506
32UTX_26944678_Chip-Seq_JUKART_Human1.93698620
33* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.78188584
34ZFX_18555785_ChIP-Seq_MESCs_Mouse1.72818040
35MYC_18358816_ChIP-ChIP_MESCs_Mouse1.70903608
36EZH2_22144423_ChIP-Seq_EOC_Human1.70442996
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.67534970
38XRN2_22483619_ChIP-Seq_HELA_Human1.67444534
39* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.66672551
40* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.66123102
41CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.61328814
42RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60583577
43NCOR1_26117541_ChIP-Seq_K562_Human1.59953951
44KDM2B_26808549_Chip-Seq_K562_Human1.59644259
45* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.58246561
46STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.55386841
47* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.55246392
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.55240610
49NELFA_20434984_ChIP-Seq_ESCs_Mouse1.54608602
50KLF4_18555785_ChIP-Seq_MESCs_Mouse1.54115656
51* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.53531799
52CLOCK_20551151_ChIP-Seq_293T_Human1.53379322
53TCF3_18692474_ChIP-Seq_MEFs_Mouse1.52810389
54FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.51135460
55AR_21909140_ChIP-Seq_LNCAP_Human1.51038682
56TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.50439105
57CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.50000795
58PKCTHETA_26484144_Chip-Seq_BREAST_Human1.46899078
59MYCN_18555785_ChIP-Seq_MESCs_Mouse1.46389689
60TP63_19390658_ChIP-ChIP_HaCaT_Human1.46162407
61TCF3_18692474_ChIP-Seq_MESCs_Mouse1.46080789
62RACK7_27058665_Chip-Seq_MCF-7_Human1.44969610
63MAF_26560356_Chip-Seq_TH2_Human1.44113066
64KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.42862406
65* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.37962489
66CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.35332596
67EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.34513803
68* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33217065
69* SA1_27219007_Chip-Seq_ERYTHROID_Human1.32348350
70PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.31561269
71KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30694066
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30556254
73MYB_26560356_Chip-Seq_TH1_Human1.29564132
74ZFP281_18757296_ChIP-ChIP_E14_Mouse1.28665138
75NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.27871714
76STAT3_1855785_ChIP-Seq_MESCs_Mouse1.26674844
77FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.25727567
78NFIB_24661679_ChIP-Seq_LUNG_Mouse1.25137891
79TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25051871
80MYC_19079543_ChIP-ChIP_MESCs_Mouse1.25021321
81CIITA_25753668_ChIP-Seq_RAJI_Human1.24524732
82TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.24150849
83KDM5A_27292631_Chip-Seq_BREAST_Human1.23800578
84ELF1_17652178_ChIP-ChIP_JURKAT_Human1.23596731
85* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.22874050
86* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.22035806
87* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.21864463
88RUNX1_22412390_ChIP-Seq_EML_Mouse1.21604233
89POU5F1_16518401_ChIP-PET_MESCs_Mouse1.19413726
90RARG_19884340_ChIP-ChIP_MEFs_Mouse1.18898282
91* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.18755581
92DCP1A_22483619_ChIP-Seq_HELA_Human1.17210205
93SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.16746603
94WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.16660471
95TFEB_21752829_ChIP-Seq_HELA_Human1.16020381
96MYB_21317192_ChIP-Seq_ERMYB_Mouse1.14842220
97* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14749126
98* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.14659279
99SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.13795963
100E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.13748498
101TP53_22127205_ChIP-Seq_IMR90_Human1.12554072
102CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.12393028
103ESR1_15608294_ChIP-ChIP_MCF-7_Human1.11269168
104UBF1/2_26484160_Chip-Seq_HMECs_Human1.09919562
105TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09668854
106CDX2_20551321_ChIP-Seq_CACO-2_Human1.09651596
107UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.09489346
108NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07722555
109CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07570318
110CHD1_26751641_Chip-Seq_LNCaP_Human1.07359739
111TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06908079
112ZNF263_19887448_ChIP-Seq_K562_Human1.06058995
113* TET1_21451524_ChIP-Seq_MESCs_Mouse1.05672111
114DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05299481
115RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.04714111
116SPI1_23127762_ChIP-Seq_K562_Human1.04469876
117* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04303236
118SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04298510
119ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04287152
120SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03732731
121THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03477386
122CREB1_26743006_Chip-Seq_LNCaP_Human1.02862059
123* MYB_26560356_Chip-Seq_TH2_Human1.02203067
124GABP_19822575_ChIP-Seq_HepG2_Human1.02174189
125BP1_19119308_ChIP-ChIP_Hs578T_Human1.01840775
126KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01463152
127RUNX1_27514584_Chip-Seq_MCF-7_Human1.00930446
128ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00910043
129ESR1_20079471_ChIP-ChIP_T-47D_Human1.00868322
130P68_20966046_ChIP-Seq_HELA_Human1.00282623
131SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00249828
132CREB1_15753290_ChIP-ChIP_HEK293T_Human0.99505403
133SMC4_20622854_ChIP-Seq_HELA_Human0.99482653
134POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99195908
135PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.98986805
136* JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.98650480
137STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.96773977
138KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96720434
139GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96023987
140NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.95855233
141* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95722251
142MYC_18555785_ChIP-Seq_MESCs_Mouse0.94128542
143WT1_19549856_ChIP-ChIP_CCG9911_Human0.93957494
144* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93758363
145ATF3_27146783_Chip-Seq_COLON_Human0.93358743
146FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.90763492
147DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90601214
148PU_27001747_Chip-Seq_BMDM_Mouse0.90593732
149* E2F1_21310950_ChIP-Seq_MCF-7_Human0.88997918
150* GATA1_19941827_ChIP-Seq_MEL_Mouse0.88518538
151ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.88130046

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color5.22874106
2MP0003303_peritoneal_inflammation4.06545333
3MP0005451_abnormal_body_composition3.46588258
4MP0005409_darkened_coat_color3.40968826
5MP0009379_abnormal_foot_pigmentation3.27724688
6MP0004381_abnormal_hair_follicle3.22102695
7MP0005174_abnormal_tail_pigmentation2.98417516
8MP0010234_abnormal_vibrissa_follicle2.88686370
9MP0003693_abnormal_embryo_hatching2.79873052
10MP0003705_abnormal_hypodermis_morpholog2.53241565
11MP0010094_abnormal_chromosome_stability2.52985126
12MP0004957_abnormal_blastocyst_morpholog2.39859678
13MP0008260_abnormal_autophagy2.39255314
14MP0003077_abnormal_cell_cycle2.27560997
15MP0005076_abnormal_cell_differentiation2.21975989
16MP0001730_embryonic_growth_arrest2.15557504
17MP0001188_hyperpigmentation2.09513510
18MP0004233_abnormal_muscle_weight2.09162641
19MP0008057_abnormal_DNA_replication1.97123374
20MP0000015_abnormal_ear_pigmentation1.91502438
21MP0000751_myopathy1.87277548
22MP0001849_ear_inflammation1.85848930
23MP0004264_abnormal_extraembryonic_tissu1.79656043
24MP0005257_abnormal_intraocular_pressure1.78931198
25MP0000537_abnormal_urethra_morphology1.78676744
26MP0003828_pulmonary_edema1.75608718
27MP0002249_abnormal_larynx_morphology1.73578284
28MP0005058_abnormal_lysosome_morphology1.67327826
29MP0005666_abnormal_adipose_tissue1.64337293
30MP0004185_abnormal_adipocyte_glucose1.62649815
31MP0000428_abnormal_craniofacial_morphol1.61276279
32MP0003300_gastrointestinal_ulcer1.60528609
33MP0000678_abnormal_parathyroid_gland1.55265228
34MP0006292_abnormal_olfactory_placode1.53742110
35MP0002177_abnormal_outer_ear1.53524963
36MP0000750_abnormal_muscle_regeneration1.51386992
37MP0008932_abnormal_embryonic_tissue1.50795331
38MP0001348_abnormal_lacrimal_gland1.48996969
39MP0004858_abnormal_nervous_system1.45649384
40MP0003984_embryonic_growth_retardation1.45023711
41MP0002080_prenatal_lethality1.43493237
42MP0009278_abnormal_bone_marrow1.42980496
43MP0000858_altered_metastatic_potential1.40951275
44MP0009672_abnormal_birth_weight1.40239724
45MP0008007_abnormal_cellular_replicative1.40097319
46MP0003221_abnormal_cardiomyocyte_apopto1.38664213
47MP0003566_abnormal_cell_adhesion1.38207287
48MP0002009_preneoplasia1.37924290
49MP0002088_abnormal_embryonic_growth/wei1.37761518
50MP0002086_abnormal_extraembryonic_tissu1.33389878
51MP0000490_abnormal_crypts_of1.33325465
52MP0000467_abnormal_esophagus_morphology1.32253691
53MP0000049_abnormal_middle_ear1.29827392
54MP0003724_increased_susceptibility_to1.27021466
55MP0003191_abnormal_cellular_cholesterol1.25797799
56MP0000733_abnormal_muscle_development1.23132070
57MP0002092_abnormal_eye_morphology1.22332956
58MP0000313_abnormal_cell_death1.21671374
59MP0002697_abnormal_eye_size1.21318877
60MP0001697_abnormal_embryo_size1.21142250
61MP0005621_abnormal_cell_physiology1.20454480
62MP0003453_abnormal_keratinocyte_physiol1.19997756
63MP0003937_abnormal_limbs/digits/tail_de1.18975991
64MP0002877_abnormal_melanocyte_morpholog1.18627252
65MP0004947_skin_inflammation1.18313991
66MP0003938_abnormal_ear_development1.18312388
67MP0004272_abnormal_basement_membrane1.18304105
68MP0003935_abnormal_craniofacial_develop1.17881826
69MP0003315_abnormal_perineum_morphology1.17431794
70MP0003091_abnormal_cell_migration1.17153808
71MP0010352_gastrointestinal_tract_polyps1.16606069
72MP0004197_abnormal_fetal_growth/weight/1.14390377
73MP0005083_abnormal_biliary_tract1.13268556
74MP0001661_extended_life_span1.13240031
75MP0005623_abnormal_meninges_morphology1.12559291
76MP0000432_abnormal_head_morphology1.11141331
77MP0003763_abnormal_thymus_physiology1.10605644
78MP0002166_altered_tumor_susceptibility1.09148675
79MP0000579_abnormal_nail_morphology1.08936544
80MP0002396_abnormal_hematopoietic_system1.07165833
81MP0002089_abnormal_postnatal_growth/wei1.06535821
82MP0003436_decreased_susceptibility_to1.05251429
83MP0002060_abnormal_skin_morphology1.03043972
84MP0009840_abnormal_foam_cell1.02728812
85MP0002933_joint_inflammation1.01182109
86MP0001216_abnormal_epidermal_layer1.01133082
87MP0003045_fibrosis1.00762166
88MP0002095_abnormal_skin_pigmentation0.99886792
89MP0004808_abnormal_hematopoietic_stem0.99503426
90MP0003385_abnormal_body_wall0.99408136
91MP0005375_adipose_tissue_phenotype0.98192950
92MP0005384_cellular_phenotype0.97073662
93MP0000371_diluted_coat_color0.96886861
94MP0010307_abnormal_tumor_latency0.96701039
95MP0008058_abnormal_DNA_repair0.95707894
96MP0003448_altered_tumor_morphology0.95698906
97MP0008438_abnormal_cutaneous_collagen0.94548643
98MP0002282_abnormal_trachea_morphology0.94034225
99MP0001873_stomach_inflammation0.93942013
100MP0002111_abnormal_tail_morphology0.93301519
101MP0003111_abnormal_nucleus_morphology0.93204592
102MP0001340_abnormal_eyelid_morphology0.90838912
103MP0003567_abnormal_fetal_cardiomyocyte0.88032691
104MP0002085_abnormal_embryonic_tissue0.87956103
105MP0009931_abnormal_skin_appearance0.87815667
106MP0005501_abnormal_skin_physiology0.86715729
107MP0002084_abnormal_developmental_patter0.85115036
108MP0002098_abnormal_vibrissa_morphology0.83153554
109MP0009333_abnormal_splenocyte_physiolog0.83120340
110MP0000377_abnormal_hair_follicle0.82269021
111MP0005023_abnormal_wound_healing0.81931642
112MP0000003_abnormal_adipose_tissue0.81558437
113MP0002019_abnormal_tumor_incidence0.80400848
114MP0000747_muscle_weakness0.80078067
115MP0000358_abnormal_cell_content/0.79720082
116MP0004782_abnormal_surfactant_physiolog0.79461214
117MP0002075_abnormal_coat/hair_pigmentati0.78669588
118MP0003959_abnormal_lean_body0.77856108
119MP0000465_gastrointestinal_hemorrhage0.77611409
120MP0005397_hematopoietic_system_phenotyp0.77297246
121MP0001545_abnormal_hematopoietic_system0.77297246
122MP0000703_abnormal_thymus_morphology0.76672635
123MP0001286_abnormal_eye_development0.76527035
124MP0001853_heart_inflammation0.76517651
125MP0001672_abnormal_embryogenesis/_devel0.76467526
126MP0005380_embryogenesis_phenotype0.76467526
127MP0001727_abnormal_embryo_implantation0.75465633
128MP0000759_abnormal_skeletal_muscle0.74889859
129MP0003868_abnormal_feces_composition0.74048812
130MP0000477_abnormal_intestine_morphology0.73713469
131MP0001800_abnormal_humoral_immune0.73260975
132MP0002796_impaired_skin_barrier0.72153749
133MP0000685_abnormal_immune_system0.71255363
134MP0005075_abnormal_melanosome_morpholog0.71146775
135MP0003656_abnormal_erythrocyte_physiolo0.71072413
136MP0002971_abnormal_brown_adipose0.70806049
137MP0001919_abnormal_reproductive_system0.70632548
138MP0000767_abnormal_smooth_muscle0.70430959
139MP0002429_abnormal_blood_cell0.70193921
140MP0003941_abnormal_skin_development0.69888770
141MP0002722_abnormal_immune_system0.69237801
142MP0010630_abnormal_cardiac_muscle0.69235231
143MP0004130_abnormal_muscle_cell0.68483565
144MP0003115_abnormal_respiratory_system0.68436814
145MP0001915_intracranial_hemorrhage0.68170772
146MP0000350_abnormal_cell_proliferation0.67868108
147MP0002398_abnormal_bone_marrow0.67390021
148MP0002102_abnormal_ear_morphology0.67013174
149MP0008770_decreased_survivor_rate0.66662156
150MP0000689_abnormal_spleen_morphology0.66511941

Predicted human phenotypes

RankGene SetZ-score
1Abnormal sex determination (HP:0012244)3.94188405
2Sex reversal (HP:0012245)3.94188405
3Obstructive sleep apnea (HP:0002870)3.39834764
4Ankle contracture (HP:0006466)3.32619971
5Asymmetry of the thorax (HP:0001555)2.82672434
6Prolonged partial thromboplastin time (HP:0003645)2.78287458
7Joint hemorrhage (HP:0005261)2.73235442
8Laryngomalacia (HP:0001601)2.72067216
9Progressive muscle weakness (HP:0003323)2.69588351
10Agammaglobulinemia (HP:0004432)2.67744866
11Ragged-red muscle fibers (HP:0003200)2.66370418
12Insomnia (HP:0100785)2.61096132
13Menorrhagia (HP:0000132)2.60832700
14Flat acetabular roof (HP:0003180)2.60365192
15Cerebral aneurysm (HP:0004944)2.59031638
16Ankyloglossia (HP:0010296)2.55539272
17Progressive external ophthalmoplegia (HP:0000590)2.48088700
18Distal lower limb amyotrophy (HP:0008944)2.47343485
19Cellulitis (HP:0100658)2.45843200
20Rectal prolapse (HP:0002035)2.41220966
21Hypochromic anemia (HP:0001931)2.37679156
22Abnormality of secondary sexual hair (HP:0009888)2.37280243
23Abnormality of the axillary hair (HP:0100134)2.37280243
24Microvesicular hepatic steatosis (HP:0001414)2.36024089
25Hyperacusis (HP:0010780)2.35183398
26Thoracic kyphosis (HP:0002942)2.33100748
27Chromosomal breakage induced by crosslinking agents (HP:0003221)2.32363151
28Elfin facies (HP:0004428)2.29651585
29Centrally nucleated skeletal muscle fibers (HP:0003687)2.29014915
30Abnormality of the fingertips (HP:0001211)2.27706764
31Thyroid-stimulating hormone excess (HP:0002925)2.27187805
32Broad face (HP:0000283)2.27003616
33Chromsome breakage (HP:0040012)2.25442446
34Pseudobulbar signs (HP:0002200)2.24879965
35Abnormality of oral frenula (HP:0000190)2.23397209
36Testicular atrophy (HP:0000029)2.23387669
37Achilles tendon contracture (HP:0001771)2.22746313
38Abnormality of the peritoneum (HP:0002585)2.22314026
39Reduced antithrombin III activity (HP:0001976)2.22306589
40Germ cell neoplasia (HP:0100728)2.20365261
41Long palpebral fissure (HP:0000637)2.18369528
42Increased connective tissue (HP:0009025)2.17044454
43Reticulocytopenia (HP:0001896)2.15256857
44Ulnar bowing (HP:0003031)2.14991581
45Abnormal platelet volume (HP:0011876)2.12593006
46Mitral valve prolapse (HP:0001634)2.12571504
47Chin dimple (HP:0010751)2.11148812
48Abnormal platelet function (HP:0011869)2.10141112
49Impaired platelet aggregation (HP:0003540)2.10141112
50Round ear (HP:0100830)2.09848565
51Abnormality of the calcaneus (HP:0008364)2.08538369
52Increased density of long bones (HP:0006392)2.07218575
53Back pain (HP:0003418)2.05446340
54Shallow orbits (HP:0000586)2.05064599
55Patellar dislocation (HP:0002999)2.04939074
56Abnormality of the distal phalanx of the thumb (HP:0009617)2.04170282
57Vertebral compression fractures (HP:0002953)2.04075131
58Selective tooth agenesis (HP:0001592)2.03231731
59Supernumerary ribs (HP:0005815)2.02905632
60Knee flexion contracture (HP:0006380)2.01836235
61Distal upper limb amyotrophy (HP:0007149)2.00593946
62Upper limb amyotrophy (HP:0009129)2.00593946
63Disproportionate tall stature (HP:0001519)2.00366612
64Syringomyelia (HP:0003396)2.00289337
65Spinal cord lesions (HP:0100561)2.00289337
66Abnormality of the Achilles tendon (HP:0005109)2.00182919
67Overriding aorta (HP:0002623)1.99859877
68Termporal pattern (HP:0011008)1.99456460
69Insidious onset (HP:0003587)1.99456460
70Micronodular cirrhosis (HP:0001413)1.96759955
71Abnormality of the distal phalanges of the toes (HP:0010182)1.94794338
72Verrucae (HP:0200043)1.94699598
73Papilloma (HP:0012740)1.94699598
74Increased mean platelet volume (HP:0011877)1.94425829
75Trismus (HP:0000211)1.93767372
76Metaphyseal cupping (HP:0003021)1.93642405
77Sparse lateral eyebrow (HP:0005338)1.92972684
78Nasal polyposis (HP:0100582)1.92810266
79Large earlobe (HP:0009748)1.91335844
80Premature rupture of membranes (HP:0001788)1.87466883
81Abnormality of the nasal mucosa (HP:0000433)1.86894635
82Rib fusion (HP:0000902)1.86770439
83Missing ribs (HP:0000921)1.86227697
84Thin bony cortex (HP:0002753)1.84863327
85Abnormality of the tricuspid valve (HP:0001702)1.84620679
86Short nail (HP:0001799)1.84351961
87Ocular albinism (HP:0001107)1.84159959
88Pointed chin (HP:0000307)1.83515124
89Abnormality of the thoracic spine (HP:0100711)1.82829659
90Vertebral arch anomaly (HP:0008438)1.82774756
91Abnormality of reticulocytes (HP:0004312)1.82384653
92Dysmetric saccades (HP:0000641)1.81233273
93Annular pancreas (HP:0001734)1.80746209
94Broad distal phalanx of finger (HP:0009836)1.80208527
95Protrusio acetabuli (HP:0003179)1.79795624
96Cholecystitis (HP:0001082)1.79240914
97Abnormal gallbladder physiology (HP:0012438)1.79240914
98Chronic obstructive pulmonary disease (HP:0006510)1.78566429
99Obstructive lung disease (HP:0006536)1.78566429
100Heterotopia (HP:0002282)1.78561892
101Ependymoma (HP:0002888)1.77750951
102Meningitis (HP:0001287)1.77691766
103Abnormal number of incisors (HP:0011064)1.77604902
104Smooth philtrum (HP:0000319)1.77220909
105Renal duplication (HP:0000075)1.76707285
106Myocardial infarction (HP:0001658)1.75121174
107Deep philtrum (HP:0002002)1.75099970
108Supernumerary bones of the axial skeleton (HP:0009144)1.73421690
109Osteolytic defects of the phalanges of the hand (HP:0009771)1.72702956
110Osteolytic defects of the hand bones (HP:0009699)1.72702956
111Renovascular hypertension (HP:0100817)1.72385764
112Craniofacial hyperostosis (HP:0004493)1.71583476
113Abnormal hemoglobin (HP:0011902)1.71178833
11411 pairs of ribs (HP:0000878)1.70985172
115Fatigue (HP:0012378)1.70634023
116Deep palmar crease (HP:0006191)1.70243191
117Advanced eruption of teeth (HP:0006288)1.69294320
118Malignant gastrointestinal tract tumors (HP:0006749)1.68135156
119Gastrointestinal carcinoma (HP:0002672)1.68135156
120Proximal placement of thumb (HP:0009623)1.67324710
121Progressive hearing impairment (HP:0001730)1.67317327
122Orthostatic hypotension (HP:0001278)1.67062586
123Colitis (HP:0002583)1.66559841
124Microcytic anemia (HP:0001935)1.66476376
125Inflammation of the large intestine (HP:0002037)1.66163167
126Multiple enchondromatosis (HP:0005701)1.65960709
127Concave nail (HP:0001598)1.65320050
128Abnormal biliary tract physiology (HP:0012439)1.64259067
129Bile duct proliferation (HP:0001408)1.64259067
130Premature ovarian failure (HP:0008209)1.64047404
131Subacute progressive viral hepatitis (HP:0006572)1.63976889
132Hyperparathyroidism (HP:0000843)1.63912502
133Reticulocytosis (HP:0001923)1.63894038
134Abnormal foot bone ossification (HP:0010675)1.63544581
135Flattened epiphyses (HP:0003071)1.63041726
136Hand muscle atrophy (HP:0009130)1.61433492
137Mildly elevated creatine phosphokinase (HP:0008180)1.61362005
138Pili torti (HP:0003777)1.61147157
139Spontaneous hematomas (HP:0007420)1.61126325
140Abnormality of cells of the erythroid lineage (HP:0012130)1.60386196
141Atrophic scars (HP:0001075)1.60149717
142Epistaxis (HP:0000421)1.59370052
143Long eyelashes (HP:0000527)1.59006153
144Seborrheic dermatitis (HP:0001051)1.58398333
145Lower limb hyperreflexia (HP:0002395)1.58286469
146Increased nuchal translucency (HP:0010880)1.58118788
147Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.57782797
148Hypoparathyroidism (HP:0000829)1.57761002
149Late onset (HP:0003584)1.57623290
150Bowel incontinence (HP:0002607)1.56271322
151Hypoplasia of the ulna (HP:0003022)1.56208151
152Abnormality of the umbilical cord (HP:0010881)1.56179882
153Overlapping toe (HP:0001845)1.56179220
154Gastrointestinal inflammation (HP:0004386)1.56023932
155Leiomyosarcoma (HP:0100243)1.55901613
156Uterine leiomyosarcoma (HP:0002891)1.55901613
157Arnold-Chiari malformation (HP:0002308)1.55594829
158High anterior hairline (HP:0009890)1.54708227
159Deviation of the thumb (HP:0009603)1.54360011
160Abnormal large intestine physiology (HP:0012700)1.54272877
161Difficulty running (HP:0009046)1.53984966
162Entropion (HP:0000621)1.53738479
163Midline defect of the nose (HP:0004122)1.53623456
164Difficulty climbing stairs (HP:0003551)1.53574858
165Elbow flexion contracture (HP:0002987)1.53271278
166Abnormality of the gastric mucosa (HP:0004295)1.52728801
167Eczematoid dermatitis (HP:0000976)1.51997870
168Abnormality of the phalanges of the hallux (HP:0010057)1.51875016
169Mitral regurgitation (HP:0001653)1.51413376
170Basal cell carcinoma (HP:0002671)1.50357593
171Lower limb amyotrophy (HP:0007210)1.48748719

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK25.42437202
2SMG14.04557182
3TLK13.36896386
4MKNK13.10929726
5EEF2K2.99996490
6TNIK2.87922335
7PRPF4B2.81578363
8MAP3K102.77957286
9BLK2.74825479
10CDK122.65435889
11CASK2.64812090
12PKN22.37771386
13FES2.35750438
14TTN2.19725606
15NLK2.05887121
16TRIB32.03387191
17FGFR41.82813319
18SCYL21.80696812
19PRKD21.57901745
20PAK21.55835651
21CSK1.49883146
22MST1R1.46666650
23TTK1.43941111
24CLK11.38945034
25BMX1.36643468
26SIK21.36608775
27MAP3K131.36051738
28SIK11.34728811
29ICK1.30172179
30RIPK11.30152346
31CDK41.25743423
32PHKG11.19097565
33PHKG21.19097565
34CDK61.16344076
35FER1.16144019
36PTK61.14981545
37STK101.14954242
38MAP4K11.14584893
39MAP3K141.12645510
40ERN11.04231081
41ALK1.02879609
42KSR21.02216779
43NME21.01395604
44RPS6KB21.00180711
45PBK0.99682547
46PRKAA20.99125939
47HIPK20.98527438
48CDK70.95256921
49DMPK0.94701896
50LATS20.93718180
51PDGFRA0.91978411
52HCK0.87470017
53LRRK20.87246110
54MTOR0.86195771
55DYRK1B0.85918283
56CHEK10.85697891
57NEK20.85025868
58FGR0.81267766
59TSSK60.80808149
60PIM10.80161683
61EIF2AK30.77442382
62CDC70.77185735
63CDK80.76730881
64PDK20.76238956
65TESK20.75276284
66BRD40.73808820
67TGFBR20.72335813
68ATR0.71508932
69TAOK30.71162248
70CDK90.71019814
71CDC42BPA0.69980370
72CAMK1G0.69136029
73IRAK40.68847682
74YES10.68739716
75MAP3K70.68294790
76MAP2K20.67394182
77EPHA20.67331865
78PDPK10.67191423
79EIF2AK10.66738805
80TAOK20.66228086
81CAMK1D0.66168949
82MAPK110.65620102
83DDR20.65151539
84AURKA0.64612493
85FLT30.64607876
86AURKB0.62300243
87UHMK10.62213218
88MAP3K80.61748833
89FGFR30.61310687
90CSF1R0.61198756
91EPHB10.61033866
92RET0.60477462
93IRAK20.60434409
94GRK60.59795738
95IRAK30.59448932
96ARAF0.58224090
97BTK0.58039273
98MAP3K10.56647617
99BUB10.56602586
100PRKD10.56003967
101RPS6KL10.55973349
102RPS6KC10.55973349
103TYRO30.55862093
104TNK20.54567470
105PAK10.54566099
106GSK3A0.53685270
107BRAF0.53288064
108CHEK20.53216983
109LCK0.52375972
110NEK60.52173541
111MELK0.51995908
112RPS6KA20.51715420
113CDK20.51490562
114SRPK10.51269709
115PASK0.50898095
116MET0.50331743
117ZAP700.50190527
118TAOK10.49299606
119CSNK1D0.48858413
120MARK20.48676334
121TYK20.46110963
122RIPK40.46044915
123NEK10.45950193
124STK40.45433455
125RPS6KB10.43292771
126PTK20.43178221
127JAK20.43147946
128RPS6KA60.42355421
129BRSK10.42302527
130TBK10.41950789
131* CDK10.41217369
132PKN10.40485250
133TRPM70.40479422
134STK110.40034138
135RPS6KA40.38889048
136RPS6KA10.38871792
137PIM20.38148964
138NEK90.37394722
139PIK3CG0.37173193
140JAK30.36548162
141MAPK150.35698789
142KIT0.35605488
143MAP2K30.34512375
144AKT20.34384196
145PRKDC0.34371897
146CAMK40.32901923
147PAK40.32469064
148LYN0.30353755
149RPS6KA50.30195504
150CSNK1E0.29750977
151ABL10.29641058
152LATS10.29469943

Predicted pathways (KEGG)

RankGene SetZ-score
1One carbon pool by folate_Homo sapiens_hsa006702.52168547
2Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.29653458
3Thyroid cancer_Homo sapiens_hsa052162.00239947
4Ribosome_Homo sapiens_hsa030101.99340206
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.99097856
6Transcriptional misregulation in cancer_Homo sapiens_hsa052021.97312620
7Lysine degradation_Homo sapiens_hsa003101.96173395
8Base excision repair_Homo sapiens_hsa034101.92836002
9Systemic lupus erythematosus_Homo sapiens_hsa053221.88954743
10Cell cycle_Homo sapiens_hsa041101.80104002
11Acute myeloid leukemia_Homo sapiens_hsa052211.79776200
12Pentose phosphate pathway_Homo sapiens_hsa000301.78748855
13Pancreatic cancer_Homo sapiens_hsa052121.77403349
14MicroRNAs in cancer_Homo sapiens_hsa052061.74874378
15Basal cell carcinoma_Homo sapiens_hsa052171.70871832
16DNA replication_Homo sapiens_hsa030301.65905487
17Biosynthesis of amino acids_Homo sapiens_hsa012301.64578753
18Small cell lung cancer_Homo sapiens_hsa052221.56527300
19Chronic myeloid leukemia_Homo sapiens_hsa052201.55513519
20Notch signaling pathway_Homo sapiens_hsa043301.51935023
21Primary immunodeficiency_Homo sapiens_hsa053401.50839411
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.48943555
23B cell receptor signaling pathway_Homo sapiens_hsa046621.43415950
24Other glycan degradation_Homo sapiens_hsa005111.42432034
25Fructose and mannose metabolism_Homo sapiens_hsa000511.38358586
26Bladder cancer_Homo sapiens_hsa052191.33743865
27* Spliceosome_Homo sapiens_hsa030401.31306266
28Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.30764988
29Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.28672834
30Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.28548513
31Prostate cancer_Homo sapiens_hsa052151.25596626
32Proteoglycans in cancer_Homo sapiens_hsa052051.25281613
33Focal adhesion_Homo sapiens_hsa045101.23577503
34NF-kappa B signaling pathway_Homo sapiens_hsa040641.20677618
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.18988655
36Fanconi anemia pathway_Homo sapiens_hsa034601.16799743
37Nucleotide excision repair_Homo sapiens_hsa034201.15905824
38AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.14142278
39Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.13888670
40Viral carcinogenesis_Homo sapiens_hsa052031.10976173
41Sulfur relay system_Homo sapiens_hsa041221.08903035
42Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.06617154
43Adherens junction_Homo sapiens_hsa045201.05643642
44Carbon metabolism_Homo sapiens_hsa012001.04307193
45Hepatitis C_Homo sapiens_hsa051601.03076588
46Wnt signaling pathway_Homo sapiens_hsa043101.00401999
47Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.00401781
48ECM-receptor interaction_Homo sapiens_hsa045120.99949672
49Non-homologous end-joining_Homo sapiens_hsa034500.99630096
50Galactose metabolism_Homo sapiens_hsa000520.99480028
51Osteoclast differentiation_Homo sapiens_hsa043800.98285560
52ErbB signaling pathway_Homo sapiens_hsa040120.96584741
53Prion diseases_Homo sapiens_hsa050200.96364226
54Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.96261142
55HTLV-I infection_Homo sapiens_hsa051660.95712253
56Regulation of actin cytoskeleton_Homo sapiens_hsa048100.95162857
57Epstein-Barr virus infection_Homo sapiens_hsa051690.94842250
58Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.94776077
59Non-small cell lung cancer_Homo sapiens_hsa052230.93625422
60Jak-STAT signaling pathway_Homo sapiens_hsa046300.93552369
61Pathways in cancer_Homo sapiens_hsa052000.92391626
62Central carbon metabolism in cancer_Homo sapiens_hsa052300.91420100
63Influenza A_Homo sapiens_hsa051640.90875456
64p53 signaling pathway_Homo sapiens_hsa041150.90799204
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.90315584
66Shigellosis_Homo sapiens_hsa051310.88436094
67Measles_Homo sapiens_hsa051620.87476125
68Nitrogen metabolism_Homo sapiens_hsa009100.85553518
69T cell receptor signaling pathway_Homo sapiens_hsa046600.85508657
70Prolactin signaling pathway_Homo sapiens_hsa049170.85169416
71Hematopoietic cell lineage_Homo sapiens_hsa046400.84587822
72Viral myocarditis_Homo sapiens_hsa054160.83973941
73Complement and coagulation cascades_Homo sapiens_hsa046100.83911636
74ABC transporters_Homo sapiens_hsa020100.83756764
75Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.83377520
76Endometrial cancer_Homo sapiens_hsa052130.82737413
77Inositol phosphate metabolism_Homo sapiens_hsa005620.82701701
78Homologous recombination_Homo sapiens_hsa034400.82444190
79mRNA surveillance pathway_Homo sapiens_hsa030150.82158954
80Dorso-ventral axis formation_Homo sapiens_hsa043200.82047765
81Staphylococcus aureus infection_Homo sapiens_hsa051500.81656537
82Amoebiasis_Homo sapiens_hsa051460.80377136
83Melanoma_Homo sapiens_hsa052180.80260727
84Toll-like receptor signaling pathway_Homo sapiens_hsa046200.80159254
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79357269
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79127928
87Hepatitis B_Homo sapiens_hsa051610.77785548
88Mismatch repair_Homo sapiens_hsa034300.76968615
89Colorectal cancer_Homo sapiens_hsa052100.76881849
90Insulin signaling pathway_Homo sapiens_hsa049100.76561785
91Melanogenesis_Homo sapiens_hsa049160.75695056
92Platelet activation_Homo sapiens_hsa046110.75657401
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.75274229
94Herpes simplex infection_Homo sapiens_hsa051680.74636923
95Cyanoamino acid metabolism_Homo sapiens_hsa004600.74509833
96Choline metabolism in cancer_Homo sapiens_hsa052310.72419145
97RNA transport_Homo sapiens_hsa030130.71272863
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70713634
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70177771
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67828362
101Malaria_Homo sapiens_hsa051440.67346755
102PI3K-Akt signaling pathway_Homo sapiens_hsa041510.66741052
103mTOR signaling pathway_Homo sapiens_hsa041500.66701657
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.65864521
105Antigen processing and presentation_Homo sapiens_hsa046120.65704522
106VEGF signaling pathway_Homo sapiens_hsa043700.65649428
107Leishmaniasis_Homo sapiens_hsa051400.64530473
108TNF signaling pathway_Homo sapiens_hsa046680.63644702
109Hippo signaling pathway_Homo sapiens_hsa043900.63632110
110Renal cell carcinoma_Homo sapiens_hsa052110.63579592
111Insulin resistance_Homo sapiens_hsa049310.63378173
112Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61971668
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61872637
114AMPK signaling pathway_Homo sapiens_hsa041520.61266486
115Toxoplasmosis_Homo sapiens_hsa051450.61044962
116Apoptosis_Homo sapiens_hsa042100.60790197
117Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.60476819
118Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60233932
119RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.59335484
120Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.58546977
121N-Glycan biosynthesis_Homo sapiens_hsa005100.57339792
122Pyrimidine metabolism_Homo sapiens_hsa002400.57016127
123Fatty acid biosynthesis_Homo sapiens_hsa000610.56827851
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55699335
125Estrogen signaling pathway_Homo sapiens_hsa049150.55643128
126Hedgehog signaling pathway_Homo sapiens_hsa043400.55449336
127Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55396816
128Dilated cardiomyopathy_Homo sapiens_hsa054140.52551514
129Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52449311
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51996085
131Adipocytokine signaling pathway_Homo sapiens_hsa049200.51943825
132Phospholipase D signaling pathway_Homo sapiens_hsa040720.51616102
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.51468332
134HIF-1 signaling pathway_Homo sapiens_hsa040660.51371950
135Glucagon signaling pathway_Homo sapiens_hsa049220.50437560
136Endocytosis_Homo sapiens_hsa041440.49649027
137Glioma_Homo sapiens_hsa052140.49575697
138Alcoholism_Homo sapiens_hsa050340.49398750
139Arginine biosynthesis_Homo sapiens_hsa002200.49011455
140Rap1 signaling pathway_Homo sapiens_hsa040150.48677604
141Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48196407
142Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46069158
143FoxO signaling pathway_Homo sapiens_hsa040680.45399722

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