DDX28

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene is intronless. It encodes an RNA-dependent ATPase. The encoded protein is localized in the mitochondria and the nucleus, and can be transported between the mitochondria and the nucleus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.01780299
2purine nucleobase biosynthetic process (GO:0009113)4.50402243
3nucleobase biosynthetic process (GO:0046112)4.40803455
4folic acid-containing compound biosynthetic process (GO:0009396)4.25405364
5deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.23072696
6folic acid metabolic process (GO:0046655)4.06756120
7glycine metabolic process (GO:0006544)3.95440323
8maturation of SSU-rRNA (GO:0030490)3.86410537
9formation of translation preinitiation complex (GO:0001731)3.81595892
10DNA strand elongation involved in DNA replication (GO:0006271)3.72968483
11DNA replication initiation (GO:0006270)3.66988399
12ribosome assembly (GO:0042255)3.62508429
13DNA unwinding involved in DNA replication (GO:0006268)3.59195075
14DNA strand elongation (GO:0022616)3.55573017
15peptidyl-arginine omega-N-methylation (GO:0035247)3.53388159
16IMP metabolic process (GO:0046040)3.52449974
17translational termination (GO:0006415)3.50457766
18viral transcription (GO:0019083)3.48801734
19ribosome biogenesis (GO:0042254)3.48615200
20ribosomal small subunit assembly (GO:0000028)3.47347500
21IMP biosynthetic process (GO:0006188)3.43677187
22ribosomal large subunit biogenesis (GO:0042273)3.33051427
23translational elongation (GO:0006414)3.31888631
24pteridine-containing compound biosynthetic process (GO:0042559)3.31808763
25ribonucleoprotein complex biogenesis (GO:0022613)3.29213482
26proteasome assembly (GO:0043248)3.28965412
27DNA replication checkpoint (GO:0000076)3.26486516
28regulation of mitochondrial translation (GO:0070129)3.24123107
29translational initiation (GO:0006413)3.21585876
30serine family amino acid biosynthetic process (GO:0009070)3.20319575
31telomere maintenance via semi-conservative replication (GO:0032201)3.19176413
32establishment of integrated proviral latency (GO:0075713)3.11756272
33pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.11043276
34negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.10671980
35mitotic metaphase plate congression (GO:0007080)3.08605627
36ribosomal small subunit biogenesis (GO:0042274)3.07330747
37deoxyribonucleotide catabolic process (GO:0009264)3.04909221
38serine family amino acid metabolic process (GO:0009069)3.04596372
39protein localization to kinetochore (GO:0034501)3.02682964
40amino acid salvage (GO:0043102)3.02067332
41L-methionine salvage (GO:0071267)3.02067332
42L-methionine biosynthetic process (GO:0071265)3.02067332
43histone arginine methylation (GO:0034969)2.98736167
44pentose-phosphate shunt (GO:0006098)2.96582354
45establishment of viral latency (GO:0019043)2.96184188
46deoxyribose phosphate catabolic process (GO:0046386)2.94293376
47negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.92927251
48rRNA transcription (GO:0009303)2.91763783
49anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.91497464
50serine family amino acid catabolic process (GO:0009071)2.89952400
51regulation of translational termination (GO:0006449)2.89804615
52mitotic nuclear envelope disassembly (GO:0007077)2.89214153
53L-serine metabolic process (GO:0006563)2.88935177
54purine deoxyribonucleotide catabolic process (GO:0009155)2.87763294
55spliceosomal snRNP assembly (GO:0000387)2.86999698
56SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.86329736
57pseudouridine synthesis (GO:0001522)2.85933414
58rRNA processing (GO:0006364)2.85484996
59base-excision repair (GO:0006284)2.84480801
60pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.84240662
61L-phenylalanine metabolic process (GO:0006558)2.83877730
62erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.83877730
63sulfur amino acid biosynthetic process (GO:0000097)2.83856506
64tetrahydrofolate metabolic process (GO:0046653)2.83629853
65peptidyl-arginine N-methylation (GO:0035246)2.83595094
66peptidyl-arginine methylation (GO:0018216)2.83595094
67folic acid-containing compound metabolic process (GO:0006760)2.83248194
68tRNA methylation (GO:0030488)2.83222578
69base-excision repair, AP site formation (GO:0006285)2.82466938
70nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.81555911
71positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.81074096
72one-carbon metabolic process (GO:0006730)2.80849168
73regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.80446443
74pyrimidine nucleotide catabolic process (GO:0006244)2.80309169
75viral mRNA export from host cell nucleus (GO:0046784)2.79597525
76cotranslational protein targeting to membrane (GO:0006613)2.78316000
77protein targeting to ER (GO:0045047)2.78049117
78pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.77071788
79L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.75800278
80negative regulation of B cell apoptotic process (GO:0002903)2.75229587
81mitotic recombination (GO:0006312)2.74950258
82rRNA metabolic process (GO:0016072)2.74462354
83cysteine metabolic process (GO:0006534)2.74426356
84cellular protein complex disassembly (GO:0043624)2.74036690
85aspartate family amino acid biosynthetic process (GO:0009067)2.72978361
862-deoxyribonucleotide biosynthetic process (GO:0009265)2.72871052
87deoxyribose phosphate biosynthetic process (GO:0046385)2.72871052
88methionine metabolic process (GO:0006555)2.72605084
89mitochondrial fusion (GO:0008053)2.72301627
90telomere maintenance via recombination (GO:0000722)2.72290412
91mitochondrial RNA metabolic process (GO:0000959)2.71393733
92viral life cycle (GO:0019058)2.70621292
93regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.70263380
94rRNA modification (GO:0000154)2.68308056
95negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.68221992
96negative regulation of ligase activity (GO:0051352)2.68221992
97protein localization to endoplasmic reticulum (GO:0070972)2.67959892
98NADPH regeneration (GO:0006740)2.67682996
99negative regulation of mRNA processing (GO:0050686)2.66339136
100regulation of cellular amino acid metabolic process (GO:0006521)2.65666031
101nuclear envelope disassembly (GO:0051081)2.65590357
102membrane disassembly (GO:0030397)2.65590357
103telomere maintenance via telomere lengthening (GO:0010833)2.65198734
104protein maturation by protein folding (GO:0022417)2.64367286
105nucleoside salvage (GO:0043174)2.64315688
106cellular component biogenesis (GO:0044085)2.63915398
107protein targeting to mitochondrion (GO:0006626)2.63442583
108establishment of protein localization to endoplasmic reticulum (GO:0072599)2.63097334
109pteridine-containing compound metabolic process (GO:0042558)2.63086682
110deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.62893992
111methionine biosynthetic process (GO:0009086)2.62822423
112mitotic chromosome condensation (GO:0007076)2.62377715
113pentose metabolic process (GO:0019321)2.61852718
114kynurenine metabolic process (GO:0070189)2.61617924
115immunoglobulin mediated immune response (GO:0016064)2.61581628
116negative regulation of RNA splicing (GO:0033119)2.60665240
117chaperone-mediated protein transport (GO:0072321)2.60377257
118transcription from mitochondrial promoter (GO:0006390)2.59973506
119AMP metabolic process (GO:0046033)2.59971880
120nucleobase-containing small molecule interconversion (GO:0015949)2.59460628
121translation (GO:0006412)2.59349861
122nucleotide-excision repair, DNA gap filling (GO:0006297)2.58805436
123pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.58012539
124UMP biosynthetic process (GO:0006222)2.58012539
125pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.58012539
126UMP metabolic process (GO:0046049)2.58012539
127iron-sulfur cluster assembly (GO:0016226)2.57315541
128metallo-sulfur cluster assembly (GO:0031163)2.57315541
129spliceosomal tri-snRNP complex assembly (GO:0000244)2.56433197
130purine nucleobase metabolic process (GO:0006144)2.56223491
131regulation of double-strand break repair via homologous recombination (GO:0010569)2.54550131
132intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.53664313
133signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.53664313
134pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.53319458
135DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.53186478
136deoxyribonucleotide biosynthetic process (GO:0009263)2.53071706
137oxidative phosphorylation (GO:0006119)2.52583757
138urea cycle (GO:0000050)2.52520380
139urea metabolic process (GO:0019627)2.52520380
1402-deoxyribonucleotide metabolic process (GO:0009394)2.52321021
141antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.52317049
142signal transduction involved in DNA damage checkpoint (GO:0072422)2.52112342
143signal transduction involved in DNA integrity checkpoint (GO:0072401)2.52112342
144DNA replication-dependent nucleosome organization (GO:0034723)2.51760719
145DNA replication-dependent nucleosome assembly (GO:0006335)2.51760719
146signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.51730411
147signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.51730411
148signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.51730411
149nucleotide salvage (GO:0043173)2.51623628
150L-phenylalanine catabolic process (GO:0006559)2.51439854
151erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.51439854
152antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.49659233
153pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.48845480
154negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.46209479
155signal transduction involved in cell cycle checkpoint (GO:0072395)2.46070991
156GDP-mannose metabolic process (GO:0019673)2.45292627
157deoxyribose phosphate metabolic process (GO:0019692)2.43161692
158B cell mediated immunity (GO:0019724)2.42660785
159DNA ligation (GO:0006266)2.41920141

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.63058684
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.96902937
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.83109954
4* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.92292883
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.87100868
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.79915053
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.76714878
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.73990166
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.69648344
10* EST1_17652178_ChIP-ChIP_JURKAT_Human2.59541436
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.51968625
12* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.49500216
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.49036496
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.39512702
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.38840655
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.27646156
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.19047952
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.11241121
19XRN2_22483619_ChIP-Seq_HELA_Human2.08772395
20* VDR_23849224_ChIP-Seq_CD4+_Human2.05677376
21CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.02571179
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.01662649
23DCP1A_22483619_ChIP-Seq_HELA_Human1.93696809
24* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.91761098
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.90993728
26PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.90728899
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.89127857
28GABP_19822575_ChIP-Seq_HepG2_Human1.88758634
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.87922643
30* FOXP3_21729870_ChIP-Seq_TREG_Human1.78341181
31AR_21909140_ChIP-Seq_LNCAP_Human1.74646567
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.74235609
33CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.73517881
34PPARA_22158963_ChIP-Seq_LIVER_Mouse1.73203110
35MYC_22102868_ChIP-Seq_BL_Human1.73143456
36RXR_22158963_ChIP-Seq_LIVER_Mouse1.71696617
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.65993597
38* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.61973240
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.61430315
40CIITA_25753668_ChIP-Seq_RAJI_Human1.59531187
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.58436870
42* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.57669102
43NANOG_18555785_ChIP-Seq_MESCs_Mouse1.56701506
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.55297600
45EGR1_23403033_ChIP-Seq_LIVER_Mouse1.54195275
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.52614448
47TTF2_22483619_ChIP-Seq_HELA_Human1.51415775
48SRF_21415370_ChIP-Seq_HL-1_Mouse1.49495514
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48743067
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.48370486
51SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.46964312
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.46269475
53STAT3_1855785_ChIP-Seq_MESCs_Mouse1.43924385
54E2F1_21310950_ChIP-Seq_MCF-7_Human1.41786911
55SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.40748702
56* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.40514706
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.36883138
58* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.35134665
59VDR_21846776_ChIP-Seq_THP-1_Human1.34367458
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.34364021
61KDM5A_27292631_Chip-Seq_BREAST_Human1.34202506
62HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32831916
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.32128718
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.28832132
65* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.27737812
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27377155
67MAF_26560356_Chip-Seq_TH1_Human1.26942633
68TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26820667
69POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25065163
70TFEB_21752829_ChIP-Seq_HELA_Human1.23768321
71VDR_24763502_ChIP-Seq_THP-1_Human1.23583337
72ZNF263_19887448_ChIP-Seq_K562_Human1.20873837
73TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20768358
74PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.20448275
75KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19921222
76SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.19618150
77UTX_26944678_Chip-Seq_JUKART_Human1.19023932
78EGR1_19374776_ChIP-ChIP_THP-1_Human1.17739853
79MAF_26560356_Chip-Seq_TH2_Human1.16347022
80STAT4_19710469_ChIP-ChIP_TH1__Mouse1.15607912
81DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14348139
82TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.14311035
83RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.12105735
84KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11108594
85CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10186247
86BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09899000
87TET1_21451524_ChIP-Seq_MESCs_Mouse1.08868581
88SPI1_23547873_ChIP-Seq_NB4_Human1.08007764
89ELK1_19687146_ChIP-ChIP_HELA_Human1.07627540
90IRF8_22096565_ChIP-ChIP_GC-B_Human1.05650463
91ELK3_25401928_ChIP-Seq_HUVEC_Human1.05449547
92SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05186903
93E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02771738
94CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02473291
95ELF1_20517297_ChIP-Seq_JURKAT_Human1.01673044
96LXR_22292898_ChIP-Seq_THP-1_Human1.01033517
97HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01024406
98MYB_21317192_ChIP-Seq_ERMYB_Mouse1.00991094
99DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.00068743
100YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00018786
101PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99513445
102MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.99440934
103CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99031364
104* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98802858
105BP1_19119308_ChIP-ChIP_Hs578T_Human0.97679771
106HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.95692686
107NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.95222983
108CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94001208
109IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.92192220
110IRF8_21731497_ChIP-ChIP_J774_Mouse0.91976864
111GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91784301
112LXR_22158963_ChIP-Seq_LIVER_Mouse0.91729384
113SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.91606932
114KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88887444
115MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.86891908
116* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.83787716
117PADI4_21655091_ChIP-ChIP_MCF-7_Human0.83188712
118OCT4_18692474_ChIP-Seq_MEFs_Mouse0.82980827

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.10565133
2MP0003693_abnormal_embryo_hatching3.90441020
3MP0009840_abnormal_foam_cell3.44692909
4MP0005360_urolithiasis3.21194756
5MP0002139_abnormal_hepatobiliary_system3.11887862
6MP0004957_abnormal_blastocyst_morpholog3.06904964
7MP0003111_abnormal_nucleus_morphology2.91128530
8MP0010094_abnormal_chromosome_stability2.84068658
9MP0005365_abnormal_bile_salt2.65140621
10MP0009278_abnormal_bone_marrow2.54465714
11MP0005085_abnormal_gallbladder_physiolo2.53703906
12MP0003077_abnormal_cell_cycle2.48483582
13MP0008875_abnormal_xenobiotic_pharmacok2.06521132
14MP0003718_maternal_effect2.03778505
15MP0008057_abnormal_DNA_replication2.01842865
16MP0008058_abnormal_DNA_repair1.91697845
17MP0003646_muscle_fatigue1.89523260
18MP0003786_premature_aging1.88602145
19MP0002396_abnormal_hematopoietic_system1.85763651
20MP0003186_abnormal_redox_activity1.84104550
21MP0010329_abnormal_lipoprotein_level1.79885494
22MP0008260_abnormal_autophagy1.79746226
23MP0003191_abnormal_cellular_cholesterol1.77995617
24MP0006036_abnormal_mitochondrial_physio1.74006894
25MP0003656_abnormal_erythrocyte_physiolo1.70061931
26MP0001730_embryonic_growth_arrest1.67109352
27MP0009333_abnormal_splenocyte_physiolog1.65133026
28MP0003303_peritoneal_inflammation1.63999757
29MP0001764_abnormal_homeostasis1.61845858
30MP0000609_abnormal_liver_physiology1.59531165
31MP0008932_abnormal_embryonic_tissue1.56956517
32MP0001790_abnormal_immune_system1.56111549
33MP0005387_immune_system_phenotype1.56111549
34MP0003011_delayed_dark_adaptation1.53384781
35MP0005332_abnormal_amino_acid1.52810869
36MP0006035_abnormal_mitochondrial_morpho1.52291660
37MP0002148_abnormal_hypersensitivity_rea1.50385610
38MP0003763_abnormal_thymus_physiology1.44404805
39MP0001835_abnormal_antigen_presentation1.39790004
40MP0010352_gastrointestinal_tract_polyps1.38531382
41MP0008007_abnormal_cellular_replicative1.38521975
42MP0002019_abnormal_tumor_incidence1.38385341
43MP0000358_abnormal_cell_content/1.37320020
44MP0000689_abnormal_spleen_morphology1.37305949
45MP0005319_abnormal_enzyme/_coenzyme1.34951300
46MP0000350_abnormal_cell_proliferation1.34473993
47MP0010307_abnormal_tumor_latency1.34401992
48MP0003436_decreased_susceptibility_to1.33762691
49MP0004808_abnormal_hematopoietic_stem1.31097347
50MP0000598_abnormal_liver_morphology1.31090728
51MP0000490_abnormal_crypts_of1.29313825
52MP0004233_abnormal_muscle_weight1.25885030
53MP0002722_abnormal_immune_system1.25361517
54MP0005397_hematopoietic_system_phenotyp1.24627780
55MP0001545_abnormal_hematopoietic_system1.24627780
56MP0000465_gastrointestinal_hemorrhage1.23688968
57MP0009785_altered_susceptibility_to1.23014401
58MP0002398_abnormal_bone_marrow1.22147372
59MP0005083_abnormal_biliary_tract1.18406540
60MP0005310_abnormal_salivary_gland1.17232176
61MP0005058_abnormal_lysosome_morphology1.16962108
62MP0003221_abnormal_cardiomyocyte_apopto1.15583784
63MP0008469_abnormal_protein_level1.14746912
64MP0005451_abnormal_body_composition1.13662712
65MP0002132_abnormal_respiratory_system1.12674713
66MP0005266_abnormal_metabolism1.11268901
67MP0005501_abnormal_skin_physiology1.10413961
68MP0000858_altered_metastatic_potential1.08288500
69MP0001800_abnormal_humoral_immune1.08056869
70MP0005025_abnormal_response_to1.07260238
71MP0002429_abnormal_blood_cell1.06932503
72MP0002080_prenatal_lethality1.05986824
73MP0001727_abnormal_embryo_implantation1.05973563
74MP0000685_abnormal_immune_system1.03344385
75MP0005671_abnormal_response_to1.03187030
76MP0005464_abnormal_platelet_physiology1.03049295
77MP0002723_abnormal_immune_serum1.02671352
78MP0000716_abnormal_immune_system1.00314070
79MP0000313_abnormal_cell_death1.00216431
80MP0001672_abnormal_embryogenesis/_devel1.00207708
81MP0005380_embryogenesis_phenotype1.00207708
82MP0001697_abnormal_embryo_size0.99290253
83MP0002163_abnormal_gland_morphology0.99116690
84MP0001853_heart_inflammation0.99111871
85MP0003705_abnormal_hypodermis_morpholog0.98891049
86MP0005670_abnormal_white_adipose0.98414186
87MP0002420_abnormal_adaptive_immunity0.97311960
88MP0001666_abnormal_nutrient_absorption0.97001201
89MP0001873_stomach_inflammation0.96731791
90MP0002405_respiratory_system_inflammati0.96389782
91MP0003123_paternal_imprinting0.96339375
92MP0001819_abnormal_immune_cell0.96093117
93MP0000703_abnormal_thymus_morphology0.95362903
94MP0002452_abnormal_antigen_presenting0.93776174
95MP0002277_abnormal_respiratory_mucosa0.93590227
96MP0001845_abnormal_inflammatory_respons0.92635799
97MP0008873_increased_physiological_sensi0.91692084
98MP0006082_CNS_inflammation0.91632699
99MP0005584_abnormal_enzyme/coenzyme_acti0.91021012
100MP0005000_abnormal_immune_tolerance0.90277024
101MP0003984_embryonic_growth_retardation0.89833362
102MP0002419_abnormal_innate_immunity0.89678336
103MP0009763_increased_sensitivity_to0.89415595
104MP0002796_impaired_skin_barrier0.87980406
105MP0001881_abnormal_mammary_gland0.87657349
106MP0002088_abnormal_embryonic_growth/wei0.87037125
107MP0002118_abnormal_lipid_homeostasis0.85827541
108MP0001661_extended_life_span0.84308680
109MP0004019_abnormal_vitamin_homeostasis0.82676966
110MP0005376_homeostasis/metabolism_phenot0.82669456
111MP0009672_abnormal_birth_weight0.82311481
112MP0005384_cellular_phenotype0.82141548
113MP0001915_intracranial_hemorrhage0.81984818
114MP0002269_muscular_atrophy0.81929252
115MP0001346_abnormal_lacrimal_gland0.80952463
116MP0005395_other_phenotype0.80501128
117MP0005621_abnormal_cell_physiology0.80149952
118MP0000015_abnormal_ear_pigmentation0.80105642
119MP0005023_abnormal_wound_healing0.79953039
120MP0009643_abnormal_urine_homeostasis0.78970953
121MP0004947_skin_inflammation0.78870727
122MP0003172_abnormal_lysosome_physiology0.76969109
123MP0004185_abnormal_adipocyte_glucose0.76681705
124MP0001348_abnormal_lacrimal_gland0.75320700
125MP0003075_altered_response_to0.73806985
126MP0005075_abnormal_melanosome_morpholog0.73334814
127MP0010155_abnormal_intestine_physiology0.72717026
128MP0003866_abnormal_defecation0.72356896
129MP0008995_early_reproductive_senescence0.72316641
130MP0002166_altered_tumor_susceptibility0.70324411
131MP0000681_abnormal_thyroid_gland0.66840416

Predicted human phenotypes

RankGene SetZ-score
1Hypobetalipoproteinemia (HP:0003563)4.44928192
2Microvesicular hepatic steatosis (HP:0001414)4.38306946
3Abnormality of cells of the erythroid lineage (HP:0012130)3.92170678
4Abnormality of aromatic amino acid family metabolism (HP:0004338)3.89613085
5Abnormal number of erythroid precursors (HP:0012131)3.79524395
6Abnormality of pyrimidine metabolism (HP:0004353)3.45465126
7Abnormality of monocarboxylic acid metabolism (HP:0010996)3.37998696
8Multiple enchondromatosis (HP:0005701)3.27169043
9Oral leukoplakia (HP:0002745)3.25529249
10Reticulocytopenia (HP:0001896)3.24928231
11Deep venous thrombosis (HP:0002625)3.23708286
12Hypertensive crisis (HP:0100735)3.15502784
13Birth length less than 3rd percentile (HP:0003561)3.13013923
14Increased intramyocellular lipid droplets (HP:0012240)3.05905673
15Xanthomatosis (HP:0000991)3.04528375
16Hypolipoproteinemia (HP:0010981)3.03592449
17Intrahepatic cholestasis (HP:0001406)2.88912851
18Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.87591184
19Hyperammonemia (HP:0001987)2.86619343
20Abnormality of methionine metabolism (HP:0010901)2.85628987
21Premature ovarian failure (HP:0008209)2.84057780
22Hyperglycinemia (HP:0002154)2.76186398
23Chronic obstructive pulmonary disease (HP:0006510)2.74068299
24Obstructive lung disease (HP:0006536)2.74068299
25Progressive external ophthalmoplegia (HP:0000590)2.72838895
26Hyperlipoproteinemia (HP:0010980)2.71686486
27Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.70849577
28Decreased activity of mitochondrial respiratory chain (HP:0008972)2.70849577
29Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.70753567
30Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.67492445
31Abnormality of serum amino acid levels (HP:0003112)2.63628517
32Abnormal mitochondria in muscle tissue (HP:0008316)2.63528673
33Spastic diplegia (HP:0001264)2.62097248
34Hyperglycinuria (HP:0003108)2.57654943
35Cholecystitis (HP:0001082)2.57038134
36Abnormal gallbladder physiology (HP:0012438)2.57038134
37Macrocytic anemia (HP:0001972)2.52094456
38Mediastinal lymphadenopathy (HP:0100721)2.51311856
39Microretrognathia (HP:0000308)2.50712991
40Breast hypoplasia (HP:0003187)2.49847621
41Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.48953713
42Abnormality of alanine metabolism (HP:0010916)2.48953713
43Hyperalaninemia (HP:0003348)2.48953713
44Abnormality of sulfur amino acid metabolism (HP:0004339)2.47998359
45Aplasia/Hypoplasia of the thymus (HP:0010515)2.47618335
46Aplasia/Hypoplasia of the sacrum (HP:0008517)2.47115645
47Abnormality of fatty-acid metabolism (HP:0004359)2.44754652
48Aplastic anemia (HP:0001915)2.44150619
49Agammaglobulinemia (HP:0004432)2.42306777
50Recurrent viral infections (HP:0004429)2.42152293
51Hepatosplenomegaly (HP:0001433)2.40263143
52Respiratory difficulties (HP:0002880)2.39153479
53Degeneration of anterior horn cells (HP:0002398)2.38459381
54Abnormality of the anterior horn cell (HP:0006802)2.38459381
55Pallor (HP:0000980)2.37105303
56Brushfield spots (HP:0001088)2.36698001
57Abnormality of aspartate family amino acid metabolism (HP:0010899)2.36586919
58Cerebral edema (HP:0002181)2.33678249
59Type I transferrin isoform profile (HP:0003642)2.33189146
60Recurrent abscess formation (HP:0002722)2.32516881
61Abnormality of serine family amino acid metabolism (HP:0010894)2.31864263
62Abnormality of glycine metabolism (HP:0010895)2.31864263
63Seborrheic dermatitis (HP:0001051)2.31788638
64Agnosia (HP:0010524)2.31191812
65Cerebral hypomyelination (HP:0006808)2.30672794
66Rhabdomyolysis (HP:0003201)2.30400942
67Increased CSF lactate (HP:0002490)2.29755029
68Chronic otitis media (HP:0000389)2.28841397
69Increased serum ferritin (HP:0003281)2.28134340
70Recurrent bacterial skin infections (HP:0005406)2.27967654
71Hepatic necrosis (HP:0002605)2.27268895
72Mitochondrial inheritance (HP:0001427)2.26766510
73Reduced antithrombin III activity (HP:0001976)2.26495873
74Squamous cell carcinoma (HP:0002860)2.23083135
75Abnormality of the common coagulation pathway (HP:0010990)2.22483390
76Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.22446015
77IgM deficiency (HP:0002850)2.22100775
78Acute necrotizing encephalopathy (HP:0006965)2.21886118
79Hepatocellular necrosis (HP:0001404)2.21833527
80Cleft eyelid (HP:0000625)2.21525494
81Cellulitis (HP:0100658)2.21375868
82Exercise intolerance (HP:0003546)2.21205470
83Abnormal trabecular bone morphology (HP:0100671)2.20783396
84Prolonged partial thromboplastin time (HP:0003645)2.20601388
85Panhypogammaglobulinemia (HP:0003139)2.20413186
86Increased serum lactate (HP:0002151)2.18412010
87Combined immunodeficiency (HP:0005387)2.17072313
88Truncus arteriosus (HP:0001660)2.16985156
89Progressive muscle weakness (HP:0003323)2.16793855
90Elevated erythrocyte sedimentation rate (HP:0003565)2.16634818
91Lethargy (HP:0001254)2.15599237
92Abnormality of iron homeostasis (HP:0011031)2.15499997
93Cellular immunodeficiency (HP:0005374)2.13876087
94Hypoalphalipoproteinemia (HP:0003233)2.13079640
95Abnormality of reticulocytes (HP:0004312)2.11999763
96Thrombocytosis (HP:0001894)2.10788804
97Lymphopenia (HP:0001888)2.10680567
98Rough bone trabeculation (HP:0100670)2.10134790
99Abnormal protein glycosylation (HP:0012346)2.10002898
100Abnormal glycosylation (HP:0012345)2.10002898
101Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.10002898
102Abnormal protein N-linked glycosylation (HP:0012347)2.10002898
103Recurrent fungal infections (HP:0002841)2.10002091
104CNS demyelination (HP:0007305)2.09738416
105Increased IgM level (HP:0003496)2.09711497
106Ragged-red muscle fibers (HP:0003200)2.06472720
107Abnormality of nucleobase metabolism (HP:0010932)2.05653502
108Abnormality of transition element cation homeostasis (HP:0011030)2.05302167
109Stomatitis (HP:0010280)2.05169713
110IgA deficiency (HP:0002720)2.02022585
111Chromsome breakage (HP:0040012)2.01740458
112Chromosomal breakage induced by crosslinking agents (HP:0003221)2.01637635
113Secondary amenorrhea (HP:0000869)2.00064936
114Hypergonadotropic hypogonadism (HP:0000815)1.99452474
115Impaired proprioception (HP:0010831)1.99181962
116Complement deficiency (HP:0004431)1.97654156
117Nausea (HP:0002018)1.96251766
118Meningitis (HP:0001287)1.96058515
119Increased serum pyruvate (HP:0003542)1.95736135
120Abnormality of glycolysis (HP:0004366)1.95736135
121Abnormality of dicarboxylic acid metabolism (HP:0010995)1.94455757
122Dicarboxylic aciduria (HP:0003215)1.94455757
123Atrophy/Degeneration involving motor neurons (HP:0007373)1.93645065
124Abnormal cartilage morphology (HP:0002763)1.92517503
125Severe combined immunodeficiency (HP:0004430)1.92439450
126Abnormality of the motor neurons (HP:0002450)1.92287510
127Abnormal neuron morphology (HP:0012757)1.92287510
128Abnormality of cells of the lymphoid lineage (HP:0012140)1.91945112
129Epidermoid cyst (HP:0200040)1.91413497
130Fatigue (HP:0012378)1.90845825
131Acute encephalopathy (HP:0006846)1.89993251
132Lactic acidosis (HP:0003128)1.89272593
133Eczematoid dermatitis (HP:0000976)1.89081938
134Gastrointestinal stroma tumor (HP:0100723)1.88765444
135Abnormality of lateral ventricle (HP:0030047)1.88536013
136Acute hepatic failure (HP:0006554)1.85538345
137Urticaria (HP:0001025)1.84500950
138Bone marrow hypocellularity (HP:0005528)1.84478325
139Lymphoma (HP:0002665)1.83625961
140Global brain atrophy (HP:0002283)1.83467217
141Megaloblastic anemia (HP:0001889)1.83164602
142Pancytopenia (HP:0001876)1.82706460
143Abnormality of complement system (HP:0005339)1.80456654
144Absent thumb (HP:0009777)1.79721410
145Patellar aplasia (HP:0006443)1.79639008
146Hyperbilirubinemia (HP:0002904)1.79295244
147Increased muscle lipid content (HP:0009058)1.79192603
148Death in infancy (HP:0001522)1.78023452
149Acanthocytosis (HP:0001927)1.77662096
1503-Methylglutaconic aciduria (HP:0003535)1.77458564
151Pustule (HP:0200039)1.77233166
152Upper motor neuron abnormality (HP:0002127)1.76842672
153Ketosis (HP:0001946)1.76618975
154Abnormality of the preputium (HP:0100587)1.75536052
155Petechiae (HP:0000967)1.75008382
156Abnormality of the intrinsic pathway (HP:0010989)1.74648156
157Abnormality of macrophages (HP:0004311)1.74392782
158CNS hypomyelination (HP:0003429)1.74127501
159Spastic paraparesis (HP:0002313)1.72515040
160Abnormality of T cell physiology (HP:0011840)1.71614171
161Trismus (HP:0000211)1.71252161
162Abnormality of the heme biosynthetic pathway (HP:0010472)1.70089865
163Carpal bone hypoplasia (HP:0001498)1.69989797

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.18189316
2NME23.69175689
3VRK23.32426745
4WEE13.20238394
5BCKDK2.95669705
6SMG12.91385041
7CDC72.49726001
8EIF2AK12.49673798
9FLT32.24104663
10NEK22.07328901
11MAP4K12.07124628
12TESK22.05734851
13SCYL22.05420997
14BRAF1.89717195
15TSSK61.84586498
16NEK11.83373159
17PRPF4B1.82686208
18PKN21.80309576
19ACVR1B1.75454876
20MAP3K111.73370882
21EIF2AK31.72745016
22KDR1.70582998
23ZAK1.70540522
24TRIB31.69288466
25RPS6KA41.63707978
26STK161.56353821
27TTK1.50661666
28RPS6KB21.48132176
29MAP3K81.47565851
30STK101.41634924
31CCNB11.41103577
32EEF2K1.39466569
33TYK21.38771591
34AKT31.36784397
35BRSK21.31526112
36ZAP701.29849321
37LRRK21.23274593
38PLK11.21576576
39ERN11.20805192
40MAPKAPK31.20589578
41CDK121.20033099
42PDK21.17758849
43TEC1.16547374
44TAOK21.13743033
45IRAK41.11719975
46PLK41.10569805
47CDK41.10221733
48TBK11.09793563
49PIM21.09625872
50IKBKB1.09092615
51PBK1.08883225
52DYRK31.08757591
53VRK11.08084205
54MAP2K31.08029797
55GRK61.06764446
56TAOK31.06541064
57AURKA1.06534590
58AURKB1.06515047
59ARAF1.05997786
60KIT1.05900181
61MAP3K131.04234837
62RIPK41.00183047
63MAP3K140.98957295
64PASK0.98565812
65NME10.98075896
66TNK20.96234147
67FGFR40.93552339
68CDK70.93369348
69PDK40.91027465
70PDK30.91027465
71BRSK10.85729515
72MAP3K100.83890041
73PIM10.82877565
74CHEK20.82280296
75TGFBR10.78956658
76BTK0.78828121
77RPS6KA50.78308477
78EPHA20.76620150
79BMX0.75114584
80TLK10.74420093
81CSNK1G30.74002608
82ATR0.73928016
83MAP3K50.71460899
84CDK90.71194375
85PAK40.68819248
86TESK10.68602264
87DAPK10.66944104
88TAF10.65211727
89ERBB40.64629662
90MAPK110.62807042
91DAPK30.61540349
92IKBKE0.61370569
93FES0.60345001
94SYK0.60087024
95MAP3K30.59789671
96MST1R0.59677868
97CDK80.59427816
98MAP3K10.59404476
99MAP2K20.59148469
100CDK190.57775774
101CHEK10.57753258
102ABL20.56844233
103CSF1R0.55790477
104BLK0.54985936
105TAOK10.53625158
106SIK30.52570394
107CSNK2A20.51958767
108RAF10.51791992
109IRAK30.51730687
110MOS0.51652877
111LATS20.50798957
112TXK0.50627277
113PLK30.50590198
114JAK30.50348245
115LYN0.49686689
116ITK0.49593945
117STK40.49414977
118MAP2K60.48945100
119PAK10.47860355
120CSNK2A10.46912064
121SRPK10.46289673
122ALK0.46257234
123NUAK10.45350191
124CSNK1A1L0.44745348
125IRAK20.43088612
126MAP3K60.39502002
127CDK20.39089374
128DYRK20.39035101
129CDK60.38476434
130AKT20.35852528
131NEK90.35564831
132CSNK1G10.34803483
133ATM0.34665193

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.36770421
2Proteasome_Homo sapiens_hsa030503.05583550
3Ribosome_Homo sapiens_hsa030102.81508478
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.49740832
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.47997912
6Mismatch repair_Homo sapiens_hsa034302.45733218
7RNA polymerase_Homo sapiens_hsa030202.41321914
8One carbon pool by folate_Homo sapiens_hsa006702.30468584
9Vitamin B6 metabolism_Homo sapiens_hsa007502.22620749
10Base excision repair_Homo sapiens_hsa034102.20522683
11Folate biosynthesis_Homo sapiens_hsa007902.11780579
12Primary bile acid biosynthesis_Homo sapiens_hsa001202.11098884
13Cysteine and methionine metabolism_Homo sapiens_hsa002702.08271085
14RNA transport_Homo sapiens_hsa030132.06074517
15Biosynthesis of amino acids_Homo sapiens_hsa012302.04030662
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.02821833
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.00749194
18Pyrimidine metabolism_Homo sapiens_hsa002402.00167637
19Drug metabolism - other enzymes_Homo sapiens_hsa009831.98527145
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.94113490
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.92810584
22Pentose phosphate pathway_Homo sapiens_hsa000301.91718801
23Spliceosome_Homo sapiens_hsa030401.83498122
24Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.77978016
25Sulfur relay system_Homo sapiens_hsa041221.72928905
26Arginine biosynthesis_Homo sapiens_hsa002201.70704933
27Selenocompound metabolism_Homo sapiens_hsa004501.62588066
28Carbon metabolism_Homo sapiens_hsa012001.58546984
29Nucleotide excision repair_Homo sapiens_hsa034201.56145668
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.47366112
31Homologous recombination_Homo sapiens_hsa034401.41147984
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.39664166
33Cell cycle_Homo sapiens_hsa041101.34968898
34Caffeine metabolism_Homo sapiens_hsa002321.33715719
35Oxidative phosphorylation_Homo sapiens_hsa001901.23610944
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.23060942
37Allograft rejection_Homo sapiens_hsa053301.19126727
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.19037764
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17459634
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.13166843
41Peroxisome_Homo sapiens_hsa041461.10803373
42Complement and coagulation cascades_Homo sapiens_hsa046101.09035757
43Autoimmune thyroid disease_Homo sapiens_hsa053201.07989874
44Asthma_Homo sapiens_hsa053101.06696244
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.06660970
46Intestinal immune network for IgA production_Homo sapiens_hsa046721.05196619
47Pentose and glucuronate interconversions_Homo sapiens_hsa000401.03485988
48Tryptophan metabolism_Homo sapiens_hsa003801.02972127
49RNA degradation_Homo sapiens_hsa030181.00243884
50Propanoate metabolism_Homo sapiens_hsa006400.99494485
51B cell receptor signaling pathway_Homo sapiens_hsa046620.98538547
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.97602127
53Pyruvate metabolism_Homo sapiens_hsa006200.97247245
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.96760154
55Fatty acid degradation_Homo sapiens_hsa000710.93672006
56beta-Alanine metabolism_Homo sapiens_hsa004100.91406205
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90449300
58Purine metabolism_Homo sapiens_hsa002300.89049398
59Leishmaniasis_Homo sapiens_hsa051400.87980539
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.87446961
61Shigellosis_Homo sapiens_hsa051310.84983106
62Viral myocarditis_Homo sapiens_hsa054160.84867218
63Antigen processing and presentation_Homo sapiens_hsa046120.84638282
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83437768
65Phenylalanine metabolism_Homo sapiens_hsa003600.83269264
66Epstein-Barr virus infection_Homo sapiens_hsa051690.81387514
67Other glycan degradation_Homo sapiens_hsa005110.80987895
68p53 signaling pathway_Homo sapiens_hsa041150.80470014
69N-Glycan biosynthesis_Homo sapiens_hsa005100.79259563
70Staphylococcus aureus infection_Homo sapiens_hsa051500.78598906
71NF-kappa B signaling pathway_Homo sapiens_hsa040640.77738804
72Graft-versus-host disease_Homo sapiens_hsa053320.76804307
73Bladder cancer_Homo sapiens_hsa052190.76503670
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76419071
75Alcoholism_Homo sapiens_hsa050340.75409926
76Non-homologous end-joining_Homo sapiens_hsa034500.75302721
77Nitrogen metabolism_Homo sapiens_hsa009100.73125979
78HTLV-I infection_Homo sapiens_hsa051660.73061376
79Glutathione metabolism_Homo sapiens_hsa004800.70841109
80Systemic lupus erythematosus_Homo sapiens_hsa053220.70759508
81Hepatitis B_Homo sapiens_hsa051610.70248949
82Fanconi anemia pathway_Homo sapiens_hsa034600.69428872
83Basal transcription factors_Homo sapiens_hsa030220.69031524
84Retinol metabolism_Homo sapiens_hsa008300.68063361
85Fructose and mannose metabolism_Homo sapiens_hsa000510.67729190
86Chronic myeloid leukemia_Homo sapiens_hsa052200.66211838
87Influenza A_Homo sapiens_hsa051640.62071458
88Arginine and proline metabolism_Homo sapiens_hsa003300.60438806
89Osteoclast differentiation_Homo sapiens_hsa043800.57543788
90Chemical carcinogenesis_Homo sapiens_hsa052040.57468070
91Non-small cell lung cancer_Homo sapiens_hsa052230.57336442
92Toll-like receptor signaling pathway_Homo sapiens_hsa046200.57255765
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56669111
94Tyrosine metabolism_Homo sapiens_hsa003500.55426491
95Metabolic pathways_Homo sapiens_hsa011000.55421021
96Galactose metabolism_Homo sapiens_hsa000520.55096247
97Primary immunodeficiency_Homo sapiens_hsa053400.55063361
98Fatty acid metabolism_Homo sapiens_hsa012120.54046160
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53840763
100PPAR signaling pathway_Homo sapiens_hsa033200.52443752
101Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51981290
102mRNA surveillance pathway_Homo sapiens_hsa030150.50794449
103Type I diabetes mellitus_Homo sapiens_hsa049400.50624541
104Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50207877
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49620982
106Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47740136
107Tuberculosis_Homo sapiens_hsa051520.47526206
108Lysosome_Homo sapiens_hsa041420.47466172
109Pancreatic cancer_Homo sapiens_hsa052120.47383156
110Alzheimers disease_Homo sapiens_hsa050100.47366354
111Hematopoietic cell lineage_Homo sapiens_hsa046400.46868653
112Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.46175905
113Fat digestion and absorption_Homo sapiens_hsa049750.44937182
114Legionellosis_Homo sapiens_hsa051340.44384928
115Histidine metabolism_Homo sapiens_hsa003400.43003245
116Herpes simplex infection_Homo sapiens_hsa051680.42653428
117Viral carcinogenesis_Homo sapiens_hsa052030.41930897
118Butanoate metabolism_Homo sapiens_hsa006500.41279001
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40278508
120Thyroid cancer_Homo sapiens_hsa052160.39960553
121Parkinsons disease_Homo sapiens_hsa050120.38988993
122Fatty acid elongation_Homo sapiens_hsa000620.37612323
123Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37104872
124Vitamin digestion and absorption_Homo sapiens_hsa049770.37027246
125Regulation of autophagy_Homo sapiens_hsa041400.36130737
126Sulfur metabolism_Homo sapiens_hsa009200.35344806
127Rheumatoid arthritis_Homo sapiens_hsa053230.34648052
128Acute myeloid leukemia_Homo sapiens_hsa052210.33690666
129Measles_Homo sapiens_hsa051620.33603966
130Starch and sucrose metabolism_Homo sapiens_hsa005000.31878936
131Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30331154
132Apoptosis_Homo sapiens_hsa042100.26333131
133Central carbon metabolism in cancer_Homo sapiens_hsa052300.25434392
134Protein export_Homo sapiens_hsa030600.24514177
135Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23640591
136Huntingtons disease_Homo sapiens_hsa050160.23335446
137Steroid hormone biosynthesis_Homo sapiens_hsa001400.21718120
138Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.21421946

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