DDX31

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)6.58473616
2polyketide metabolic process (GO:0030638)6.58473616
3doxorubicin metabolic process (GO:0044598)6.58473616
4protein localization to kinetochore (GO:0034501)6.12116299
5ribosome assembly (GO:0042255)5.43344491
6negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.09173237
7protein localization to chromosome, centromeric region (GO:0071459)5.08885303
8regulation of nuclear cell cycle DNA replication (GO:0033262)4.92292745
9regulation of telomere maintenance via telomerase (GO:0032210)4.87222539
10nuclear pore complex assembly (GO:0051292)4.84266530
11negative regulation of cell cycle G2/M phase transition (GO:1902750)4.79250228
12rRNA transcription (GO:0009303)4.69824676
13nuclear pore organization (GO:0006999)4.60515395
14DNA replication-dependent nucleosome assembly (GO:0006335)4.54002861
15DNA replication-dependent nucleosome organization (GO:0034723)4.54002861
16rRNA methylation (GO:0031167)4.51934051
17rRNA modification (GO:0000154)4.50101265
18DNA replication checkpoint (GO:0000076)4.49980940
19histone H4-K12 acetylation (GO:0043983)4.49568173
20mitotic sister chromatid segregation (GO:0000070)4.47219695
21regulation of translation in response to stress (GO:0043555)4.39859770
22negative regulation of telomerase activity (GO:0051974)4.36755215
23histone H4-K8 acetylation (GO:0043982)4.35974844
24histone H4-K5 acetylation (GO:0043981)4.35974844
25maintenance of protein location in nucleus (GO:0051457)4.34336079
26heterochromatin organization (GO:0070828)4.32218770
27regulation of mammary gland epithelial cell proliferation (GO:0033599)4.25186151
28mitotic sister chromatid cohesion (GO:0007064)4.23618122
29ribosome biogenesis (GO:0042254)4.15187667
30negative regulation of epidermis development (GO:0045683)4.11485087
31regulation of translational fidelity (GO:0006450)4.09651988
32aminoglycoside antibiotic metabolic process (GO:0030647)4.06697485
33formation of translation preinitiation complex (GO:0001731)4.05671007
34DNA unwinding involved in DNA replication (GO:0006268)3.96532038
35DNA replication initiation (GO:0006270)3.91959428
36somite rostral/caudal axis specification (GO:0032525)3.90948320
37pore complex assembly (GO:0046931)3.89556694
38sister chromatid segregation (GO:0000819)3.84204587
39protein complex localization (GO:0031503)3.83026413
40DNA duplex unwinding (GO:0032508)3.79036738
41cellular protein complex localization (GO:0034629)3.75217437
42DNA geometric change (GO:0032392)3.74312565
43chromatin assembly (GO:0031497)3.69089621
44negative regulation of telomere maintenance (GO:0032205)3.60683623
45mitotic chromosome condensation (GO:0007076)3.58995124
46negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.58768247
47muscle organ morphogenesis (GO:0048644)3.54931306
48pseudouridine synthesis (GO:0001522)3.54852037
49positive regulation of DNA-dependent DNA replication (GO:2000105)3.46756008
50regulation of response to osmotic stress (GO:0047484)3.44811772
51regulation of centriole replication (GO:0046599)3.41355144
52ribonucleoprotein complex biogenesis (GO:0022613)3.37514344
53mitotic nuclear envelope disassembly (GO:0007077)3.37098921
54folic acid-containing compound biosynthetic process (GO:0009396)3.37029033
55positive regulation of chromosome segregation (GO:0051984)3.36255030
56telomere maintenance via recombination (GO:0000722)3.34755785
57establishment of integrated proviral latency (GO:0075713)3.33630025
58Golgi transport vesicle coating (GO:0048200)3.32435491
59COPI coating of Golgi vesicle (GO:0048205)3.32435491
60ribosomal large subunit biogenesis (GO:0042273)3.32323581
61tRNA aminoacylation for protein translation (GO:0006418)3.32186447
62regulation of translational termination (GO:0006449)3.31927358
63maturation of SSU-rRNA (GO:0030490)3.31493293
64negative regulation of epidermal cell differentiation (GO:0045605)3.30292775
65mitotic metaphase plate congression (GO:0007080)3.29468775
66histone H4-K16 acetylation (GO:0043984)3.28431659
67pteridine-containing compound biosynthetic process (GO:0042559)3.25947148
68tRNA aminoacylation (GO:0043039)3.25655820
69amino acid activation (GO:0043038)3.25655820
70spliceosomal tri-snRNP complex assembly (GO:0000244)3.25363538
71RNA stabilization (GO:0043489)3.22017366
72mRNA stabilization (GO:0048255)3.22017366
73DNA strand elongation involved in DNA replication (GO:0006271)3.20034213
74nucleobase biosynthetic process (GO:0046112)3.18755777
75mitotic recombination (GO:0006312)3.18602835
76tRNA methylation (GO:0030488)3.17306674
77mitochondrial DNA replication (GO:0006264)3.16778061
78maturation of 5.8S rRNA (GO:0000460)3.13686994
79regulation of RNA export from nucleus (GO:0046831)3.12813451
80nuclear envelope organization (GO:0006998)3.12675199
81pre-miRNA processing (GO:0031054)3.11923959
82IMP biosynthetic process (GO:0006188)3.11792023
83cytidine metabolic process (GO:0046087)3.11372001
84cytidine catabolic process (GO:0006216)3.11372001
85cytidine deamination (GO:0009972)3.11372001
86regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.11226280
87interferon-gamma production (GO:0032609)3.10492720
88membrane disassembly (GO:0030397)3.10222595
89nuclear envelope disassembly (GO:0051081)3.10222595
90regulation of MHC class I biosynthetic process (GO:0045343)3.08988868
91regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.08399616
92negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.06280151
93mitochondrial RNA metabolic process (GO:0000959)3.05612574
94protein localization to chromosome (GO:0034502)3.05537516
95double-strand break repair via nonhomologous end joining (GO:0006303)3.04408190
96non-recombinational repair (GO:0000726)3.04408190
97ribosomal small subunit biogenesis (GO:0042274)3.03807178
98cullin deneddylation (GO:0010388)3.03111082
99DNA strand elongation (GO:0022616)3.02862574
100regulation of chromosome segregation (GO:0051983)3.01617581
101establishment of chromosome localization (GO:0051303)2.99133246
102proteasome assembly (GO:0043248)2.98531214
103attachment of spindle microtubules to kinetochore (GO:0008608)2.98046409
104DNA conformation change (GO:0071103)2.98023247
105spliceosomal snRNP assembly (GO:0000387)2.97807987
106notochord development (GO:0030903)2.96216535
107regulation of mitotic spindle organization (GO:0060236)2.95657016
108regulation of spindle organization (GO:0090224)2.95188587
109regulation of apoptotic process involved in morphogenesis (GO:1902337)2.94604528
110regulation of sister chromatid cohesion (GO:0007063)2.93307923
111regulation of double-strand break repair (GO:2000779)2.93118727
112purine nucleobase biosynthetic process (GO:0009113)2.92233833
113CENP-A containing nucleosome assembly (GO:0034080)2.91056765
114regulation of telomere maintenance (GO:0032204)2.90261717
115negative regulation of mRNA metabolic process (GO:1903312)2.89664922
116spindle checkpoint (GO:0031577)2.88600093
117mitotic spindle checkpoint (GO:0071174)2.88473130
118negative regulation of mRNA processing (GO:0050686)2.87309509
119chromosome condensation (GO:0030261)2.87111804
120negative regulation of chromosome segregation (GO:0051985)2.86788952
121establishment of viral latency (GO:0019043)2.85176267
122DNA damage response, detection of DNA damage (GO:0042769)2.85115263
123regulation of double-strand break repair via homologous recombination (GO:0010569)2.83280342
124IMP metabolic process (GO:0046040)2.83274163
125positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.83240415
126positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.83240415
127positive regulation of mitotic sister chromatid separation (GO:1901970)2.83240415
128protein deneddylation (GO:0000338)2.82710668
129chromatin assembly or disassembly (GO:0006333)2.82059930
130mitochondrial DNA metabolic process (GO:0032042)2.81577851
131mRNA cleavage (GO:0006379)2.80816800
132regulation of centrosome cycle (GO:0046605)2.79817596
133nucleobase-containing small molecule interconversion (GO:0015949)2.79427264
134regulation of DNA-dependent DNA replication (GO:0090329)2.78633939
135chromatin remodeling at centromere (GO:0031055)2.78576109
136metaphase plate congression (GO:0051310)2.78090936
137primitive streak formation (GO:0090009)2.77424531
1383-UTR-mediated mRNA stabilization (GO:0070935)2.77298493
139mitotic spindle assembly checkpoint (GO:0007094)2.76488068
1407-methylguanosine mRNA capping (GO:0006370)2.76378773
141mitotic G2/M transition checkpoint (GO:0044818)2.76199571
142rRNA processing (GO:0006364)2.75816873
143termination of RNA polymerase II transcription (GO:0006369)2.74695437
144regulation of telomerase activity (GO:0051972)2.73945465
145negative regulation of mitotic sister chromatid segregation (GO:0033048)2.73762159
146negative regulation of mitotic sister chromatid separation (GO:2000816)2.73762159
147negative regulation of sister chromatid segregation (GO:0033046)2.73762159
148negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.73762159
149negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.73762159
150spindle assembly (GO:0051225)2.72914719
151somatic hypermutation of immunoglobulin genes (GO:0016446)2.72862442
152somatic diversification of immune receptors via somatic mutation (GO:0002566)2.72862442
153maintenance of protein localization in organelle (GO:0072595)2.72012311
154nucleoside transmembrane transport (GO:1901642)2.71876762
155spindle assembly checkpoint (GO:0071173)2.71501518
156telomere maintenance via semi-conservative replication (GO:0032201)2.71429072
157transcription from mitochondrial promoter (GO:0006390)2.68598390
158regulation of cilium movement (GO:0003352)2.68009228
159rRNA metabolic process (GO:0016072)2.66515884

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.45171531
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.68230862
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.48564669
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.48564669
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.48564669
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.48261265
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.37773254
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.30439629
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.25425257
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.82428698
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.67684560
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.59849662
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.42513636
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.42467005
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.36942194
16* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.26412723
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.26055367
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.18441023
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.09835188
20* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.07216849
21ZNF263_19887448_ChIP-Seq_K562_Human2.04930057
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.03394923
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.00779444
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.98929004
25POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.93317311
26SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.89580426
27MYC_22102868_ChIP-Seq_BL_Human1.87992642
28POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.80610066
29EGR1_19374776_ChIP-ChIP_THP-1_Human1.80377951
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.79464096
31NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.78615538
32FOXP3_21729870_ChIP-Seq_TREG_Human1.76615012
33XRN2_22483619_ChIP-Seq_HELA_Human1.72584020
34NELFA_20434984_ChIP-Seq_ESCs_Mouse1.69150301
35NANOG_18555785_ChIP-Seq_MESCs_Mouse1.68436073
36E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.67811651
37* VDR_23849224_ChIP-Seq_CD4+_Human1.62726256
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.61333471
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.58734694
40STAT3_1855785_ChIP-Seq_MESCs_Mouse1.57370668
41* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.53757261
42* GABP_19822575_ChIP-Seq_HepG2_Human1.52141413
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.51837829
44TCF3_18692474_ChIP-Seq_MEFs_Mouse1.51466035
45AR_21909140_ChIP-Seq_LNCAP_Human1.49964752
46* NOTCH1_21737748_ChIP-Seq_TLL_Human1.49184182
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.49144878
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48348700
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.47215707
50SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.46338581
51* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.44917154
52CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.43900280
53* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.43694878
54CIITA_25753668_ChIP-Seq_RAJI_Human1.41973690
55TCF3_18692474_ChIP-Seq_MESCs_Mouse1.41563001
56PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.41532694
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.37816413
58ELF1_17652178_ChIP-ChIP_JURKAT_Human1.36624598
59KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.35893560
60KDM5A_27292631_Chip-Seq_BREAST_Human1.35105970
61DCP1A_22483619_ChIP-Seq_HELA_Human1.34126104
62NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.33140416
63TTF2_22483619_ChIP-Seq_HELA_Human1.32963107
64E2F1_21310950_ChIP-Seq_MCF-7_Human1.27972980
65SRF_21415370_ChIP-Seq_HL-1_Mouse1.27906621
66ESR1_15608294_ChIP-ChIP_MCF-7_Human1.27290055
67ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25063528
68CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.24494750
69HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.21677703
70NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.20070427
71TFEB_21752829_ChIP-Seq_HELA_Human1.18368013
72ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.18267733
73HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17858969
74TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.16766582
75* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.16716245
76SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15848777
77NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.15211615
78YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14928977
79* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14477209
80E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13211973
81ELK1_19687146_ChIP-ChIP_HELA_Human1.12029015
82CHD1_26751641_Chip-Seq_LNCaP_Human1.08731516
83* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06580209
84IRF1_19129219_ChIP-ChIP_H3396_Human1.05983738
85MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.03494146
86ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.02339208
87SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.01699044
88NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.01554138
89TP63_17297297_ChIP-ChIP_HaCaT_Human1.00381687
90OCT4_18692474_ChIP-Seq_MEFs_Mouse0.99410894
91NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.99317216
92* ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.98281316
93ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.98190683
94HIF1A_21447827_ChIP-Seq_MCF-7_Human0.98142161
95FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.98000135
96* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97271136
97POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.97246483
98* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95830083
99CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94686617
100SPI1_23547873_ChIP-Seq_NB4_Human0.94327952
101* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.93981307
102NANOG_21062744_ChIP-ChIP_HESCs_Human0.93880833
103CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.93524325
104DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92943264
105VDR_21846776_ChIP-Seq_THP-1_Human0.92529643
106HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92166050
107TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91189390
108PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.91003157
109KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.90804721
110TBX5_21415370_ChIP-Seq_HL-1_Mouse0.89309819
111TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88768293
112SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.87789525
113EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.87426043
114SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86915833
115* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86902989
116PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86792480
117SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.86129997
118CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.86040213
119FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.85981043
120SOX17_20123909_ChIP-Seq_XEN_Mouse0.85756516
121BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85674070
122SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.85506298
123ELK1_22589737_ChIP-Seq_MCF10A_Human0.85484265
124SOX2_18692474_ChIP-Seq_MEFs_Mouse0.84785582
125* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.84670448
126KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.82233931
127PKCTHETA_26484144_Chip-Seq_BREAST_Human0.81169034
128ATF3_27146783_Chip-Seq_COLON_Human0.80041674
129SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.78709617

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004957_abnormal_blastocyst_morpholog3.95252216
2MP0008057_abnormal_DNA_replication3.60379585
3MP0004264_abnormal_extraembryonic_tissu3.51516886
4MP0003693_abnormal_embryo_hatching3.26409402
5MP0010094_abnormal_chromosome_stability3.15068551
6MP0006292_abnormal_olfactory_placode3.07052436
7MP0003011_delayed_dark_adaptation3.01977954
8MP0003111_abnormal_nucleus_morphology2.95307555
9MP0003077_abnormal_cell_cycle2.92490728
10MP0003890_abnormal_embryonic-extraembry2.89248579
11MP0010352_gastrointestinal_tract_polyps2.78181742
12MP0010234_abnormal_vibrissa_follicle2.76566992
13MP0005075_abnormal_melanosome_morpholog2.56504315
14MP0002254_reproductive_system_inflammat2.50071760
15MP0002396_abnormal_hematopoietic_system2.42457521
16MP0004233_abnormal_muscle_weight2.30119370
17MP0009697_abnormal_copulation2.17469690
18MP0005257_abnormal_intraocular_pressure2.09601642
19MP0001672_abnormal_embryogenesis/_devel2.08467413
20MP0005380_embryogenesis_phenotype2.08467413
21MP0008058_abnormal_DNA_repair2.08155123
22MP0003123_paternal_imprinting2.02719670
23MP0000350_abnormal_cell_proliferation2.02315756
24MP0003121_genomic_imprinting2.01327840
25MP0003984_embryonic_growth_retardation1.95727061
26MP0008007_abnormal_cellular_replicative1.94320962
27MP0002088_abnormal_embryonic_growth/wei1.94274357
28MP0005394_taste/olfaction_phenotype1.92577468
29MP0005499_abnormal_olfactory_system1.92577468
30MP0005076_abnormal_cell_differentiation1.86575367
31MP0003705_abnormal_hypodermis_morpholog1.76415810
32MP0001730_embryonic_growth_arrest1.74095987
33MP0008932_abnormal_embryonic_tissue1.68213663
34MP0003122_maternal_imprinting1.67763975
35MP0000537_abnormal_urethra_morphology1.66260727
36MP0000678_abnormal_parathyroid_gland1.65880197
37MP0006035_abnormal_mitochondrial_morpho1.62403077
38MP0003183_abnormal_peptide_metabolism1.57883980
39MP0000490_abnormal_crypts_of1.54207375
40MP0003786_premature_aging1.53763716
41MP0002086_abnormal_extraembryonic_tissu1.50886797
42MP0002085_abnormal_embryonic_tissue1.46516540
43MP0003806_abnormal_nucleotide_metabolis1.44190481
44MP0000313_abnormal_cell_death1.42638117
45MP0004858_abnormal_nervous_system1.41642572
46MP0002796_impaired_skin_barrier1.41564457
47MP0005501_abnormal_skin_physiology1.41262180
48MP0004185_abnormal_adipocyte_glucose1.41029591
49MP0002877_abnormal_melanocyte_morpholog1.40984685
50MP0001697_abnormal_embryo_size1.38318316
51MP0002653_abnormal_ependyma_morphology1.36440974
52MP0002080_prenatal_lethality1.34897132
53MP0002332_abnormal_exercise_endurance1.30719843
54MP0002084_abnormal_developmental_patter1.30480313
55MP0001661_extended_life_span1.29763383
56MP0001849_ear_inflammation1.28524210
57MP0009672_abnormal_birth_weight1.24001476
58MP0001881_abnormal_mammary_gland1.23270237
59MP0010030_abnormal_orbit_morphology1.22718586
60MP0002019_abnormal_tumor_incidence1.22042665
61MP0004197_abnormal_fetal_growth/weight/1.21580263
62MP0001293_anophthalmia1.21101628
63MP0001346_abnormal_lacrimal_gland1.20429617
64MP0005451_abnormal_body_composition1.19377134
65MP0003941_abnormal_skin_development1.17796144
66MP0003950_abnormal_plasma_membrane1.16679586
67MP0003315_abnormal_perineum_morphology1.15450143
68MP0000372_irregular_coat_pigmentation1.14816256
69MP0010307_abnormal_tumor_latency1.14703034
70MP0004808_abnormal_hematopoietic_stem1.13484456
71MP0002277_abnormal_respiratory_mucosa1.10674553
72MP0006082_CNS_inflammation1.10602884
73MP0008260_abnormal_autophagy1.09956616
74MP0002092_abnormal_eye_morphology1.09138370
75MP0001216_abnormal_epidermal_layer1.07496080
76MP0003718_maternal_effect1.07221374
77MP0000358_abnormal_cell_content/1.05860661
78MP0005408_hypopigmentation1.05772574
79MP0002060_abnormal_skin_morphology1.04459673
80MP0000579_abnormal_nail_morphology1.03342434
81MP0002722_abnormal_immune_system1.03242170
82MP0000627_abnormal_mammary_gland1.02470227
83MP0001727_abnormal_embryo_implantation1.01394686
84MP0000689_abnormal_spleen_morphology0.99237236
85MP0009333_abnormal_splenocyte_physiolog0.99215513
86MP0002127_abnormal_cardiovascular_syste0.98197080
87MP0003453_abnormal_keratinocyte_physiol0.97803379
88MP0008961_abnormal_basal_metabolism0.95591313
89MP0002398_abnormal_bone_marrow0.95322914
90MP0000703_abnormal_thymus_morphology0.94815259
91MP0003938_abnormal_ear_development0.94716641
92MP0002970_abnormal_white_adipose0.94707801
93MP0000428_abnormal_craniofacial_morphol0.94337289
94MP0005623_abnormal_meninges_morphology0.94280759
95MP0002697_abnormal_eye_size0.94274880
96MP0005266_abnormal_metabolism0.92628557
97MP0000858_altered_metastatic_potential0.92266361
98MP0010678_abnormal_skin_adnexa0.91038058
99MP0002098_abnormal_vibrissa_morphology0.89979140
100MP0000377_abnormal_hair_follicle0.89814794
101MP0002009_preneoplasia0.89801319
102MP0003119_abnormal_digestive_system0.89072174
103MP0005384_cellular_phenotype0.87498492
104MP0002932_abnormal_joint_morphology0.85828211
105MP0003763_abnormal_thymus_physiology0.84591819
106MP0009053_abnormal_anal_canal0.84276025
107MP0002132_abnormal_respiratory_system0.83579121
108MP0003221_abnormal_cardiomyocyte_apopto0.83473867
109MP0003186_abnormal_redox_activity0.83005705
110MP0001915_intracranial_hemorrhage0.82846049
111MP0002429_abnormal_blood_cell0.82674421
112MP0002114_abnormal_axial_skeleton0.81434821
113MP0002210_abnormal_sex_determination0.80969724
114MP0003937_abnormal_limbs/digits/tail_de0.79892158
115MP0000432_abnormal_head_morphology0.78961765
116MP0008789_abnormal_olfactory_epithelium0.77322226
117MP0005023_abnormal_wound_healing0.76616898
118MP0000049_abnormal_middle_ear0.76302574
119MP0005621_abnormal_cell_physiology0.75911143
120MP0000427_abnormal_hair_cycle0.75588858
121MP0001145_abnormal_male_reproductive0.74991880
122MP0003283_abnormal_digestive_organ0.74179785
123MP0003943_abnormal_hepatobiliary_system0.74133675
124MP0009703_decreased_birth_body0.72716580
125MP0002269_muscular_atrophy0.71816721
126MP0000716_abnormal_immune_system0.71085535
127MP0002160_abnormal_reproductive_system0.70190664
128MP0000762_abnormal_tongue_morphology0.69685769
129MP0003935_abnormal_craniofacial_develop0.69543551
130MP0008770_decreased_survivor_rate0.69155557
131MP0000647_abnormal_sebaceous_gland0.68942916
132MP0000733_abnormal_muscle_development0.68173310
133MP0000750_abnormal_muscle_regeneration0.68068851
134MP0003448_altered_tumor_morphology0.68051234
135MP0005187_abnormal_penis_morphology0.67688093
136MP0001929_abnormal_gametogenesis0.66716882
137MP0000467_abnormal_esophagus_morphology0.65968565
138MP0002405_respiratory_system_inflammati0.65237103
139MP0002925_abnormal_cardiovascular_devel0.65169485
140MP0001800_abnormal_humoral_immune0.63926560
141MP0002006_tumorigenesis0.63909360
142MP0004133_heterotaxia0.63844684
143MP0003566_abnormal_cell_adhesion0.63342502
144MP0006036_abnormal_mitochondrial_physio0.62843276
145MP0001286_abnormal_eye_development0.62803360
146MP0005671_abnormal_response_to0.62518666
147MP0002111_abnormal_tail_morphology0.62131180
148MP0005058_abnormal_lysosome_morphology0.61052494
149MP0001243_abnormal_dermal_layer0.60794104
150MP0001348_abnormal_lacrimal_gland0.60793044

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)5.44125404
2Multiple enchondromatosis (HP:0005701)5.10064427
3Ependymoma (HP:0002888)5.05950800
4Hypochromic microcytic anemia (HP:0004840)4.43094627
5Progressive external ophthalmoplegia (HP:0000590)4.40221620
6Hepatoblastoma (HP:0002884)4.07186189
7Chromosomal breakage induced by crosslinking agents (HP:0003221)4.02874008
8Rhabdomyosarcoma (HP:0002859)3.88586184
9Neoplasm of striated muscle (HP:0009728)3.85841789
10Chromsome breakage (HP:0040012)3.73033178
11Rib fusion (HP:0000902)3.53248511
12Aplastic anemia (HP:0001915)3.51940915
13Abnormality of the lower motor neuron (HP:0002366)3.42517729
14Trismus (HP:0000211)3.31597676
15Sensory axonal neuropathy (HP:0003390)3.30420979
16Nephroblastoma (Wilms tumor) (HP:0002667)3.27954423
17Astrocytoma (HP:0009592)3.23342451
18Abnormality of the astrocytes (HP:0100707)3.23342451
19Embryonal renal neoplasm (HP:0011794)2.99127024
20Meckel diverticulum (HP:0002245)2.98718266
21Reduced antithrombin III activity (HP:0001976)2.98020185
22Septate vagina (HP:0001153)2.94007990
23Medulloblastoma (HP:0002885)2.91283419
24Ragged-red muscle fibers (HP:0003200)2.91039767
25Glossoptosis (HP:0000162)2.89088633
26Testicular atrophy (HP:0000029)2.87314962
27Progressive muscle weakness (HP:0003323)2.86342446
28Hyperinsulinemic hypoglycemia (HP:0000825)2.84781905
29Glioma (HP:0009733)2.79953627
30Abnormality of the ileum (HP:0001549)2.77542686
31Aplasia/Hypoplasia of the uvula (HP:0010293)2.77495441
32Abnormal lung lobation (HP:0002101)2.73711104
33Impulsivity (HP:0100710)2.71664286
34Aplasia/Hypoplasia of the fovea (HP:0008060)2.69835192
35Hypoplasia of the fovea (HP:0007750)2.69835192
36Microretrognathia (HP:0000308)2.69809882
37Impaired proprioception (HP:0010831)2.69704581
38Prominent metopic ridge (HP:0005487)2.68856696
39Sparse lateral eyebrow (HP:0005338)2.66017872
40Entropion (HP:0000621)2.65488493
41Fatigue (HP:0012378)2.58927202
42Preauricular skin tag (HP:0000384)2.54072190
43Fused cervical vertebrae (HP:0002949)2.53221622
44Rectovaginal fistula (HP:0000143)2.51495084
45Rectal fistula (HP:0100590)2.51495084
46Increased nuchal translucency (HP:0010880)2.49886326
47Abnormal cartilage morphology (HP:0002763)2.47438074
48Myelodysplasia (HP:0002863)2.47341977
49Amyotrophic lateral sclerosis (HP:0007354)2.45309959
50Abnormality of the salivary glands (HP:0010286)2.42404544
51Hyperacusis (HP:0010780)2.42359000
52Abnormality of chromosome stability (HP:0003220)2.41018787
53Deep philtrum (HP:0002002)2.40635255
54Supernumerary spleens (HP:0009799)2.39567291
55Hypochromic anemia (HP:0001931)2.38942026
56Aplasia/hypoplasia of the humerus (HP:0006507)2.37366318
57Deviation of the thumb (HP:0009603)2.36066683
58Atrophy/Degeneration involving motor neurons (HP:0007373)2.34854892
59Premature ovarian failure (HP:0008209)2.32182835
60Microvesicular hepatic steatosis (HP:0001414)2.31683545
61Intestinal fistula (HP:0100819)2.31403513
62Secondary amenorrhea (HP:0000869)2.29863160
63Abnormality of the preputium (HP:0100587)2.29394628
64Squamous cell carcinoma (HP:0002860)2.27527909
65Small intestinal stenosis (HP:0012848)2.27053893
66Duodenal stenosis (HP:0100867)2.27053893
67Aplasia/Hypoplasia of the sternum (HP:0006714)2.26977469
68Skin tags (HP:0010609)2.26426849
69Proximal placement of thumb (HP:0009623)2.24180003
70Overlapping toe (HP:0001845)2.23675903
71Type I transferrin isoform profile (HP:0003642)2.23224757
72Short 5th finger (HP:0009237)2.23095148
73Pili torti (HP:0003777)2.22964449
74Hypergonadotropic hypogonadism (HP:0000815)2.22236224
75Tongue fasciculations (HP:0001308)2.21635461
76Shoulder girdle muscle weakness (HP:0003547)2.21216228
77Sloping forehead (HP:0000340)2.21216134
78Bifid tongue (HP:0010297)2.21105668
79Short humerus (HP:0005792)2.20209369
80Selective tooth agenesis (HP:0001592)2.20201381
81Bone marrow hypocellularity (HP:0005528)2.18929227
82Poikiloderma (HP:0001029)2.18223410
83Partial duplication of thumb phalanx (HP:0009944)2.15836865
84Vaginal fistula (HP:0004320)2.15420068
85Aplasia/Hypoplasia of the sacrum (HP:0008517)2.14949287
86Cleft eyelid (HP:0000625)2.14874548
87Progressive hearing impairment (HP:0001730)2.14621312
88Nasal polyposis (HP:0100582)2.13621113
89Combined immunodeficiency (HP:0005387)2.13470751
90Rough bone trabeculation (HP:0100670)2.11658751
91Birth length less than 3rd percentile (HP:0003561)2.10021370
92Missing ribs (HP:0000921)2.09271388
93Spinal muscular atrophy (HP:0007269)2.08860450
94Abnormality of DNA repair (HP:0003254)2.06477674
95Prominent nose (HP:0000448)2.05567309
96Facial cleft (HP:0002006)2.05411907
97Overriding aorta (HP:0002623)2.04403197
98Abnormality of the metopic suture (HP:0005556)2.03783185
99Shawl scrotum (HP:0000049)2.02886312
100Abnormality of the anterior horn cell (HP:0006802)2.01985158
101Degeneration of anterior horn cells (HP:0002398)2.01985158
102Atresia of the external auditory canal (HP:0000413)2.01167845
103Urethral obstruction (HP:0000796)2.00309181
104Adenoma sebaceum (HP:0009720)1.99321493
105Angiofibromas (HP:0010615)1.99321493
106Upper motor neuron abnormality (HP:0002127)1.97237113
107Abnormality of the distal phalanges of the toes (HP:0010182)1.97022367
108Malignant neoplasm of the central nervous system (HP:0100836)1.96910653
109Abnormality of the duodenum (HP:0002246)1.96889538
110Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.96402002
111Dysphonia (HP:0001618)1.95777652
112Long palpebral fissure (HP:0000637)1.94433809
113Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.94021308
114Abnormality of chromosome segregation (HP:0002916)1.93628475
115Horizontal nystagmus (HP:0000666)1.93537378
116Muscle fibrillation (HP:0010546)1.93124266
117Anal stenosis (HP:0002025)1.93119579
118Abnormality of the fovea (HP:0000493)1.92246578
119Neoplasm of the heart (HP:0100544)1.92162637
120Abnormality of the intrinsic pathway (HP:0010989)1.91227993
121Pendular nystagmus (HP:0012043)1.90768206
122Abnormality of small intestinal villus morphology (HP:0011472)1.90374018
123Villous atrophy (HP:0011473)1.90374018
124Insomnia (HP:0100785)1.90109654
125Cafe-au-lait spot (HP:0000957)1.89987704
126Cutaneous melanoma (HP:0012056)1.89869073
127Breast hypoplasia (HP:0003187)1.89340874
128Hypopigmentation of the fundus (HP:0007894)1.88827496
129Abnormality of the carotid arteries (HP:0005344)1.88517280
130Abnormality of glycolysis (HP:0004366)1.87908307
131Increased serum pyruvate (HP:0003542)1.87908307
132Partial duplication of the phalanx of hand (HP:0009999)1.87327496
133Short nail (HP:0001799)1.85703455
134Renal duplication (HP:0000075)1.84377876
135Reticulocytopenia (HP:0001896)1.84294215
136Pelvic girdle muscle weakness (HP:0003749)1.83307055
137Horseshoe kidney (HP:0000085)1.79885380
138Ureteral duplication (HP:0000073)1.77858348
139Abnormalities of placenta or umbilical cord (HP:0001194)1.77724657
140Abnormal protein glycosylation (HP:0012346)1.77667138
141Abnormal glycosylation (HP:0012345)1.77667138
142Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.77667138
143Abnormal protein N-linked glycosylation (HP:0012347)1.77667138
144Sparse eyelashes (HP:0000653)1.75997364
145Abnormality of the umbilical cord (HP:0010881)1.75288891
146Lower limb hyperreflexia (HP:0002395)1.74332316
147Abnormality of placental membranes (HP:0011409)1.74091292
148Amniotic constriction ring (HP:0009775)1.74091292
149Choanal atresia (HP:0000453)1.72462829
150Elfin facies (HP:0004428)1.72256617
151Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.72248453
152Natal tooth (HP:0000695)1.71859471
153Aplasia cutis congenita (HP:0001057)1.70845697
154Symptomatic seizures (HP:0011145)1.70149404
155Absent radius (HP:0003974)1.68935825
156Capillary hemangiomas (HP:0005306)1.66928046
157Deep palmar crease (HP:0006191)1.66050834
158Increased serum lactate (HP:0002151)1.64488830
159Abnormal trabecular bone morphology (HP:0100671)1.62751568
160Spastic diplegia (HP:0001264)1.62670732
161Submucous cleft hard palate (HP:0000176)1.61213456
162Abnormality of methionine metabolism (HP:0010901)1.59741598
163Hypokinesia (HP:0002375)1.55350019
16411 pairs of ribs (HP:0000878)1.53149544

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.22594886
2ERN13.86240765
3GRK63.53070322
4GRK53.50710428
5TTK2.87065852
6BUB12.72689182
7MST42.72464019
8CSF1R2.51173317
9PBK2.45754244
10SMG12.43678783
11ADRBK22.43126673
12STK102.42812926
13WEE12.32714521
14CDC72.28162250
15MST1R2.17319786
16TGFBR22.08847320
17GRK12.06256748
18CDK71.94330272
19BRSK21.88833742
20ICK1.74337817
21MAP3K101.72309143
22PLK11.70301113
23IRAK31.69703906
24MATK1.63286183
25MAPK71.63263290
26CHEK21.62136478
27PDK21.50936047
28NEK21.47410645
29TYRO31.42592318
30PASK1.41896044
31GRK71.36738226
32PAK41.36685232
33EPHA21.35205979
34VRK21.34333297
35MOS1.33386541
36TRIB31.33001671
37CDK41.26230737
38BRAF1.19876380
39CHEK11.16570199
40AURKB1.14264144
41SRPK11.13241176
42BRD41.12247431
43HIPK21.11302879
44MET1.09188036
45TRIM281.06740748
46ATR1.05804506
47SCYL21.05487013
48ACVR1B1.02273906
49EIF2AK10.98914103
50NME10.97360094
51DYRK30.96166300
52PRKG20.95531751
53TSSK60.91636335
54ALK0.90498377
55ERBB40.88913893
56AURKA0.87449071
57RPS6KB20.86137166
58ITK0.85841576
59CAMK40.83895467
60RAF10.83606055
61TAF10.83126306
62MAP4K10.82527610
63BRSK10.82045313
64NME20.80118625
65FLT30.77703209
66TESK20.76859866
67PIM20.76835820
68WNK10.76639593
69ATM0.74268437
70MAP3K80.73090372
71CDK20.72626230
72EIF2AK30.72264151
73PRKCI0.71091537
74AKT20.67963847
75ZAP700.67775968
76MARK20.66960663
77FGFR30.65533610
78ADRBK10.63699616
79VRK10.61539106
80CLK10.60513223
81AKT30.58992704
82MTOR0.58436633
83TLK10.57285309
84CSK0.57083492
85EIF2AK20.57059518
86MAPK110.54954863
87MAP2K60.54015108
88NTRK10.53882469
89RPS6KA40.52174281
90MAP3K140.50924862
91MAP3K90.50745144
92PAK10.49943740
93LATS20.48884632
94LATS10.48113800
95NEK10.48028764
96PIM10.47721795
97TRPM70.47049509
98SIK10.45777920
99BLK0.45395800
100MAP2K30.44599931
101NEK90.44050040
102ARAF0.43906578
103EEF2K0.43832929
104PLK30.43531094
105STK160.42385404
106CDK10.41988284
107STK40.41184423
108STK240.40889100
109KIT0.40829037
110MAP2K40.40564595
111MARK30.39761590
112STK30.39480124
113PNCK0.38260280
114CSNK2A10.37535833
115CDK80.36976463
116MAPKAPK30.36855233
117PRKDC0.35497930
118MKNK20.35261807
119TAOK10.35233421
120BTK0.34339747
121IKBKB0.33326102
122RIPK10.33276423
123PTK20.32980972
124MAP3K30.32871510
125CDK60.32651161
126MAP3K20.31478776
127PAK20.30263837
128SIK30.29837706
129KSR20.29679483
130MAPKAPK50.29528623
131MKNK10.29491210
132RPS6KA50.29202981
133CSNK1E0.28571502
134TAOK20.28351946
135JAK30.28083008
136ZAK0.26611080
137IGF1R0.26368973
138MAPKAPK20.26159440
139CSNK2A20.25202544
140PLK40.24736733
141MELK0.22804563
142MAPK140.21980379

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.56069064
2DNA replication_Homo sapiens_hsa030303.97671294
3Vitamin B6 metabolism_Homo sapiens_hsa007503.82387894
4Mismatch repair_Homo sapiens_hsa034303.35495907
5RNA transport_Homo sapiens_hsa030132.88577989
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.83622294
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.63968322
8Homologous recombination_Homo sapiens_hsa034402.48854368
9Cell cycle_Homo sapiens_hsa041102.47665943
10One carbon pool by folate_Homo sapiens_hsa006702.46163897
11Spliceosome_Homo sapiens_hsa030402.44934455
12RNA polymerase_Homo sapiens_hsa030202.31098113
13Ribosome_Homo sapiens_hsa030102.29414105
14Base excision repair_Homo sapiens_hsa034102.18259091
15Fanconi anemia pathway_Homo sapiens_hsa034602.04842602
16Nucleotide excision repair_Homo sapiens_hsa034202.02261163
17Fructose and mannose metabolism_Homo sapiens_hsa000511.93135267
18Galactose metabolism_Homo sapiens_hsa000521.72504646
19RNA degradation_Homo sapiens_hsa030181.71778134
20mRNA surveillance pathway_Homo sapiens_hsa030151.71315907
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.70804988
22Pyrimidine metabolism_Homo sapiens_hsa002401.69478090
23Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.63174277
24p53 signaling pathway_Homo sapiens_hsa041151.57162095
25Basal transcription factors_Homo sapiens_hsa030221.56994892
26Proteasome_Homo sapiens_hsa030501.53618603
27Non-homologous end-joining_Homo sapiens_hsa034501.46540325
28Thyroid cancer_Homo sapiens_hsa052161.36397175
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.29148229
30Folate biosynthesis_Homo sapiens_hsa007901.23240505
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.09440913
32Arachidonic acid metabolism_Homo sapiens_hsa005901.08978625
33Sulfur relay system_Homo sapiens_hsa041221.08754681
34Antigen processing and presentation_Homo sapiens_hsa046121.01238333
35mTOR signaling pathway_Homo sapiens_hsa041501.00402622
36Herpes simplex infection_Homo sapiens_hsa051680.98809486
37Selenocompound metabolism_Homo sapiens_hsa004500.97275161
38Pentose phosphate pathway_Homo sapiens_hsa000300.93528052
39Viral carcinogenesis_Homo sapiens_hsa052030.90459707
40N-Glycan biosynthesis_Homo sapiens_hsa005100.88579990
41Other glycan degradation_Homo sapiens_hsa005110.88498965
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88179760
43Pyruvate metabolism_Homo sapiens_hsa006200.87781651
44Primary immunodeficiency_Homo sapiens_hsa053400.85535748
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85310196
46Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84349990
47RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.82289777
48Linoleic acid metabolism_Homo sapiens_hsa005910.81357376
49Epstein-Barr virus infection_Homo sapiens_hsa051690.81166557
50Maturity onset diabetes of the young_Homo sapiens_hsa049500.81046443
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80258364
52MicroRNAs in cancer_Homo sapiens_hsa052060.79410895
53Glycosaminoglycan degradation_Homo sapiens_hsa005310.75321660
54Purine metabolism_Homo sapiens_hsa002300.74537310
55NF-kappa B signaling pathway_Homo sapiens_hsa040640.73701700
56Prostate cancer_Homo sapiens_hsa052150.72426503
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.70973356
58HTLV-I infection_Homo sapiens_hsa051660.67641358
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67403464
60Steroid biosynthesis_Homo sapiens_hsa001000.66856238
61Apoptosis_Homo sapiens_hsa042100.60701430
62Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60688192
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60103468
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60054540
65Adherens junction_Homo sapiens_hsa045200.59809895
66Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59684860
67Acute myeloid leukemia_Homo sapiens_hsa052210.58890273
68Bladder cancer_Homo sapiens_hsa052190.57909187
69Glutathione metabolism_Homo sapiens_hsa004800.57025141
70Biosynthesis of amino acids_Homo sapiens_hsa012300.56396871
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56031046
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.55641848
73Sulfur metabolism_Homo sapiens_hsa009200.54259622
74Legionellosis_Homo sapiens_hsa051340.53988596
75Systemic lupus erythematosus_Homo sapiens_hsa053220.53946648
76Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53300313
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52501045
78Regulation of autophagy_Homo sapiens_hsa041400.49167448
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.48825831
80Non-small cell lung cancer_Homo sapiens_hsa052230.46739039
81Alcoholism_Homo sapiens_hsa050340.43729871
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43207214
83Small cell lung cancer_Homo sapiens_hsa052220.42469307
84Fatty acid elongation_Homo sapiens_hsa000620.41977895
85Oocyte meiosis_Homo sapiens_hsa041140.40560670
86Pathways in cancer_Homo sapiens_hsa052000.40417825
87Shigellosis_Homo sapiens_hsa051310.40321154
88TGF-beta signaling pathway_Homo sapiens_hsa043500.39861693
89Huntingtons disease_Homo sapiens_hsa050160.39191435
90Endometrial cancer_Homo sapiens_hsa052130.38953998
91Melanoma_Homo sapiens_hsa052180.37794878
92Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37397908
93Vibrio cholerae infection_Homo sapiens_hsa051100.37312995
94Hippo signaling pathway_Homo sapiens_hsa043900.37274924
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37093370
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36049917
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.35550093
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34512842
99Inositol phosphate metabolism_Homo sapiens_hsa005620.34254916
100Pancreatic cancer_Homo sapiens_hsa052120.32919453
101Colorectal cancer_Homo sapiens_hsa052100.31847993
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31845504
103Arginine and proline metabolism_Homo sapiens_hsa003300.31611140
104Carbon metabolism_Homo sapiens_hsa012000.31038119
105B cell receptor signaling pathway_Homo sapiens_hsa046620.30695007
106Wnt signaling pathway_Homo sapiens_hsa043100.30653557
107Intestinal immune network for IgA production_Homo sapiens_hsa046720.30077601
108Measles_Homo sapiens_hsa051620.30030961
109Leishmaniasis_Homo sapiens_hsa051400.29865708
110Proteoglycans in cancer_Homo sapiens_hsa052050.29839350
111Influenza A_Homo sapiens_hsa051640.29749209
112Chronic myeloid leukemia_Homo sapiens_hsa052200.29074653
113T cell receptor signaling pathway_Homo sapiens_hsa046600.28571792
114Tight junction_Homo sapiens_hsa045300.27840195
115Notch signaling pathway_Homo sapiens_hsa043300.27593480
116Propanoate metabolism_Homo sapiens_hsa006400.25642210
117Cyanoamino acid metabolism_Homo sapiens_hsa004600.25403302
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25063527
119Metabolic pathways_Homo sapiens_hsa011000.25012495
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24967019
121AMPK signaling pathway_Homo sapiens_hsa041520.23956528
122Hematopoietic cell lineage_Homo sapiens_hsa046400.23494480
123Hepatitis B_Homo sapiens_hsa051610.23430840
124ErbB signaling pathway_Homo sapiens_hsa040120.23333537
125Protein export_Homo sapiens_hsa030600.23047432
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.22848251
127Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.22618645
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.22606545
129Leukocyte transendothelial migration_Homo sapiens_hsa046700.21738720
130Jak-STAT signaling pathway_Homo sapiens_hsa046300.19308801
131Lysine degradation_Homo sapiens_hsa003100.18004358
132Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.17289514

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