DDX39A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the DEAD box protein family. These proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD) and are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene is thought to play a role in the prognosis of patients with gastrointestinal stromal tumors. A pseudogene of this gene is present on chromosome 13. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)4.51193235
2DNA strand elongation (GO:0022616)4.35887069
3telomere maintenance via semi-conservative replication (GO:0032201)4.25175387
4DNA unwinding involved in DNA replication (GO:0006268)4.01996160
5negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.89067411
6proteasome assembly (GO:0043248)3.80934675
7DNA replication initiation (GO:0006270)3.72267502
8regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.69734791
9anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.67514575
10positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.67149457
11negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.60019804
12negative regulation of ligase activity (GO:0051352)3.60019804
13establishment of integrated proviral latency (GO:0075713)3.59528319
14mitotic sister chromatid segregation (GO:0000070)3.56713978
15mitotic chromosome condensation (GO:0007076)3.56512271
16telomere maintenance via recombination (GO:0000722)3.51756787
17DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.33851292
18DNA synthesis involved in DNA repair (GO:0000731)3.32294082
19signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.31478025
20intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.31478025
21mitotic metaphase plate congression (GO:0007080)3.30421063
22signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.29281266
23signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.29281266
24signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.29281266
25mitotic recombination (GO:0006312)3.27514171
26deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.26813324
27signal transduction involved in DNA integrity checkpoint (GO:0072401)3.26660119
28signal transduction involved in DNA damage checkpoint (GO:0072422)3.26660119
29establishment of viral latency (GO:0019043)3.23825433
30ribosome biogenesis (GO:0042254)3.22882594
31formation of translation preinitiation complex (GO:0001731)3.22308293
32positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.21466688
33signal transduction involved in cell cycle checkpoint (GO:0072395)3.18724047
34sister chromatid segregation (GO:0000819)3.18284711
35maturation of SSU-rRNA (GO:0030490)3.15498444
36ribosomal small subunit biogenesis (GO:0042274)3.14396950
37DNA ligation (GO:0006266)3.14296385
38ribosome assembly (GO:0042255)3.12951322
39positive regulation of ligase activity (GO:0051351)3.07556396
40mitotic nuclear envelope disassembly (GO:0007077)3.07266769
41regulation of cellular amino acid metabolic process (GO:0006521)3.06720828
42negative regulation of B cell apoptotic process (GO:0002903)3.04476387
43antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.03877964
44ribonucleoprotein complex biogenesis (GO:0022613)3.03815743
45DNA topological change (GO:0006265)3.03561118
46negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.02601415
47rRNA modification (GO:0000154)2.99951926
48synapsis (GO:0007129)2.97051039
49regulation of ubiquitin-protein transferase activity (GO:0051438)2.94895436
50telomere maintenance via telomere lengthening (GO:0010833)2.93637290
51nucleotide-excision repair, DNA gap filling (GO:0006297)2.92644865
52pseudouridine synthesis (GO:0001522)2.90988773
53rRNA processing (GO:0006364)2.89980444
54DNA replication checkpoint (GO:0000076)2.88833852
55G1/S transition of mitotic cell cycle (GO:0000082)2.88623366
56cell cycle G1/S phase transition (GO:0044843)2.88623366
57spliceosomal snRNP assembly (GO:0000387)2.86876783
58antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.86211309
59protein localization to chromosome, centromeric region (GO:0071459)2.85125340
60membrane disassembly (GO:0030397)2.84672051
61nuclear envelope disassembly (GO:0051081)2.84672051
62regulation of ligase activity (GO:0051340)2.84306835
63ribosomal small subunit assembly (GO:0000028)2.83612518
64transcription from mitochondrial promoter (GO:0006390)2.83331541
65transcription-coupled nucleotide-excision repair (GO:0006283)2.83086142
66nucleobase biosynthetic process (GO:0046112)2.79717011
67regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.79527132
68rRNA metabolic process (GO:0016072)2.75598228
69protein localization to kinetochore (GO:0034501)2.75162270
70folic acid-containing compound biosynthetic process (GO:0009396)2.74699216
71chromosome organization involved in meiosis (GO:0070192)2.73855649
72negative regulation of mRNA processing (GO:0050686)2.73619960
73viral mRNA export from host cell nucleus (GO:0046784)2.72128148
74CENP-A containing nucleosome assembly (GO:0034080)2.71653456
75deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.69529500
76purine nucleobase biosynthetic process (GO:0009113)2.69389649
77ribosomal large subunit biogenesis (GO:0042273)2.69381218
78negative regulation of chromosome segregation (GO:0051985)2.66943219
79metaphase plate congression (GO:0051310)2.65920117
80IMP biosynthetic process (GO:0006188)2.64911845
81meiosis I (GO:0007127)2.64419305
82positive regulation of cell cycle arrest (GO:0071158)2.64232544
83protein maturation by protein folding (GO:0022417)2.64212262
84base-excision repair (GO:0006284)2.63999517
85mitotic spindle assembly checkpoint (GO:0007094)2.63626269
86deoxyribonucleotide biosynthetic process (GO:0009263)2.63412169
87chromatin remodeling at centromere (GO:0031055)2.63069477
88tRNA methylation (GO:0030488)2.62446275
89negative regulation of RNA splicing (GO:0033119)2.60923961
90mitotic spindle checkpoint (GO:0071174)2.60574021
91DNA catabolic process, exonucleolytic (GO:0000738)2.60011354
92kinetochore organization (GO:0051383)2.59994953
93meiotic chromosome segregation (GO:0045132)2.59990275
94negative regulation of mitotic sister chromatid separation (GO:2000816)2.59438115
95negative regulation of sister chromatid segregation (GO:0033046)2.59438115
96negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.59438115
97negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.59438115
98negative regulation of mitotic sister chromatid segregation (GO:0033048)2.59438115
99pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.59267270
100protein targeting to mitochondrion (GO:0006626)2.59233131

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.27333026
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.57421169
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.43678501
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.34765763
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.18872133
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.15440030
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.08416411
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.91672855
9* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.82413284
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.73356568
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.70633140
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.59376596
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.58983562
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.56862857
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.55837922
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.53194588
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.52138299
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.45516896
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.34250740
20XRN2_22483619_ChIP-Seq_HELA_Human2.16592267
21MYC_22102868_ChIP-Seq_BL_Human2.15097469
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.13448036
23DCP1A_22483619_ChIP-Seq_HELA_Human2.13425575
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.12905211
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.01954434
26NELFA_20434984_ChIP-Seq_ESCs_Mouse1.99204864
27FOXP3_21729870_ChIP-Seq_TREG_Human1.96500212
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.96282853
29VDR_23849224_ChIP-Seq_CD4+_Human1.96253887
30GABP_19822575_ChIP-Seq_HepG2_Human1.90484538
31VDR_21846776_ChIP-Seq_THP-1_Human1.84944444
32CIITA_25753668_ChIP-Seq_RAJI_Human1.80612273
33YY1_21170310_ChIP-Seq_MESCs_Mouse1.77753336
34E2F1_18555785_ChIP-Seq_MESCs_Mouse1.77734290
35TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.76132281
36TTF2_22483619_ChIP-Seq_HELA_Human1.71831701
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.69774117
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.69206259
39CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.68385291
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67511943
41PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.64824942
42FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.62785796
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.61364516
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.60203305
45MYCN_18555785_ChIP-Seq_MESCs_Mouse1.58374218
46DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.57244250
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.56139430
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.56063903
49KDM5A_27292631_Chip-Seq_BREAST_Human1.55040197
50TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.52411609
51TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52356118
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.51304686
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49309496
54CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.45377910
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44740843
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44341478
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.42739259
58MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.38640331
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.37833715
60HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.36558884
61CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.33065891
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29730739
63BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.29032283
64MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.28028565
65NANOG_18555785_ChIP-Seq_MESCs_Mouse1.26116178
66CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.24751524
67E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.24454813
68EGR1_19374776_ChIP-ChIP_THP-1_Human1.24295681
69STAT4_19710469_ChIP-ChIP_TH1__Mouse1.23494318
70SPI1_23547873_ChIP-Seq_NB4_Human1.20440248
71TFEB_21752829_ChIP-Seq_HELA_Human1.18887564
72CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.18866735
73ELK1_19687146_ChIP-ChIP_HELA_Human1.14600195
74MAF_26560356_Chip-Seq_TH1_Human1.14362132
75CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.13713968
76STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12561564
77MAF_26560356_Chip-Seq_TH2_Human1.12214563
78IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.11893918
79GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.10102216
80HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09476578
81CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08243409
82UTX_26944678_Chip-Seq_JUKART_Human1.07800312
83AR_21909140_ChIP-Seq_LNCAP_Human1.06000142
84NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.03385653
85KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02003589
86MYB_26560356_Chip-Seq_TH2_Human1.00821708
87SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96252391
88MYB_26560356_Chip-Seq_TH1_Human0.96201042
89CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96141537
90PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96115344
91NOTCH1_21737748_ChIP-Seq_TLL_Human0.95689949
92ELF1_20517297_ChIP-Seq_JURKAT_Human0.93174556
93CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92735494
94BP1_19119308_ChIP-ChIP_Hs578T_Human0.92095576
95IRF8_22096565_ChIP-ChIP_GC-B_Human0.91320999
96MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.90635903
97RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.90542013
98PU.1_20513432_ChIP-Seq_Bcells_Mouse0.90361475
99ZNF263_19887448_ChIP-Seq_K562_Human0.90315982
100TET1_21451524_ChIP-Seq_MESCs_Mouse0.88706264

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.35728456
2MP0010094_abnormal_chromosome_stability4.31596518
3MP0003111_abnormal_nucleus_morphology4.05263524
4MP0008058_abnormal_DNA_repair3.80278026
5MP0003077_abnormal_cell_cycle3.30823333
6MP0004957_abnormal_blastocyst_morpholog3.27395071
7MP0003763_abnormal_thymus_physiology2.76784398
8MP0003806_abnormal_nucleotide_metabolis2.67741566
9MP0008057_abnormal_DNA_replication2.67597129
10MP0003786_premature_aging2.61020045
11MP0009333_abnormal_splenocyte_physiolog2.59154295
12MP0008007_abnormal_cellular_replicative2.55929990
13MP0001835_abnormal_antigen_presentation2.38704816
14MP0002396_abnormal_hematopoietic_system2.36555764
15MP0001853_heart_inflammation2.25711632
16MP0008932_abnormal_embryonic_tissue2.13055944
17MP0005671_abnormal_response_to1.92573922
18MP0002398_abnormal_bone_marrow1.90881084
19MP0000703_abnormal_thymus_morphology1.86007211
20MP0000685_abnormal_immune_system1.85879755
21MP0003436_decreased_susceptibility_to1.77200696
22MP0001800_abnormal_humoral_immune1.75519349
23MP0000490_abnormal_crypts_of1.72933723
24MP0002722_abnormal_immune_system1.69508336
25MP0001730_embryonic_growth_arrest1.68918092
26MP0006036_abnormal_mitochondrial_physio1.68799606
27MP0000350_abnormal_cell_proliferation1.68780616
28MP0002019_abnormal_tumor_incidence1.68091596
29MP0001873_stomach_inflammation1.67331919
30MP0008260_abnormal_autophagy1.66627406
31MP0005000_abnormal_immune_tolerance1.64366858
32MP0000313_abnormal_cell_death1.63695731
33MP0006035_abnormal_mitochondrial_morpho1.62964186
34MP0000689_abnormal_spleen_morphology1.61831828
35MP0002420_abnormal_adaptive_immunity1.57245977
36MP0004808_abnormal_hematopoietic_stem1.54453635
37MP0001819_abnormal_immune_cell1.54244179
38MP0002429_abnormal_blood_cell1.52722509
39MP0000716_abnormal_immune_system1.48852859
40MP0002723_abnormal_immune_serum1.48694038
41MP0002452_abnormal_antigen_presenting1.48565274
42MP0002877_abnormal_melanocyte_morpholog1.48312166
43MP0002148_abnormal_hypersensitivity_rea1.42080940
44MP0009278_abnormal_bone_marrow1.40113361
45MP0005387_immune_system_phenotype1.38647001
46MP0001790_abnormal_immune_system1.38647001
47MP0005025_abnormal_response_to1.35909396
48MP0005058_abnormal_lysosome_morphology1.35265122
49MP0002210_abnormal_sex_determination1.30993131
50MP0002166_altered_tumor_susceptibility1.29425737
51MP0003718_maternal_effect1.28945524
52MP0009785_altered_susceptibility_to1.23148128
53MP0002405_respiratory_system_inflammati1.22825374
54MP0002080_prenatal_lethality1.22423399
55MP0000015_abnormal_ear_pigmentation1.22125193
56MP0005075_abnormal_melanosome_morpholog1.19717099
57MP0008995_early_reproductive_senescence1.16567307
58MP0001929_abnormal_gametogenesis1.15452290
59MP0002006_tumorigenesis1.14406990
60MP0008877_abnormal_DNA_methylation1.13871784
61MP0000358_abnormal_cell_content/1.11515100
62MP0005451_abnormal_body_composition1.10408781
63MP0005397_hematopoietic_system_phenotyp1.09387654
64MP0001545_abnormal_hematopoietic_system1.09387654
65MP0000372_irregular_coat_pigmentation1.08560640
66MP0001697_abnormal_embryo_size1.06880296
67MP0002419_abnormal_innate_immunity1.04671030
68MP0003186_abnormal_redox_activity1.04406180
69MP0001145_abnormal_male_reproductive1.01659566
70MP0001672_abnormal_embryogenesis/_devel1.00896348
71MP0005380_embryogenesis_phenotype1.00896348
72MP0005464_abnormal_platelet_physiology1.00566300
73MP0010307_abnormal_tumor_latency0.94666419
74MP0004185_abnormal_adipocyte_glucose0.93381805
75MP0003656_abnormal_erythrocyte_physiolo0.89115340
76MP0001845_abnormal_inflammatory_respons0.88900770
77MP0005501_abnormal_skin_physiology0.88511744
78MP0010155_abnormal_intestine_physiology0.88069199
79MP0003984_embryonic_growth_retardation0.87634282
80MP0004947_skin_inflammation0.86832181
81MP0000653_abnormal_sex_gland0.83570988
82MP0001727_abnormal_embryo_implantation0.83193357
83MP0001764_abnormal_homeostasis0.82652171
84MP0002088_abnormal_embryonic_growth/wei0.81831696
85MP0000858_altered_metastatic_potential0.81043880
86MP0005310_abnormal_salivary_gland0.78520526
87MP0003303_peritoneal_inflammation0.77930187
88MP0004381_abnormal_hair_follicle0.76698833
89MP0003866_abnormal_defecation0.76153160
90MP0005384_cellular_phenotype0.75921984
91MP0001119_abnormal_female_reproductive0.74515516
92MP0000465_gastrointestinal_hemorrhage0.74080008
93MP0002095_abnormal_skin_pigmentation0.73951235
94MP0005076_abnormal_cell_differentiation0.72724681
95MP0008469_abnormal_protein_level0.72564868
96MP0005621_abnormal_cell_physiology0.72235384
97MP0009697_abnormal_copulation0.71457642
98MP0002163_abnormal_gland_morphology0.71387176
99MP0002132_abnormal_respiratory_system0.68974198
100MP0003699_abnormal_female_reproductive0.67631203

Predicted human phenotypes

RankGene SetZ-score
1Microvesicular hepatic steatosis (HP:0001414)4.35958045
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.46053000
3Rough bone trabeculation (HP:0100670)3.08798368
4Panhypogammaglobulinemia (HP:0003139)3.02579917
5Type I transferrin isoform profile (HP:0003642)3.01936169
6Agammaglobulinemia (HP:0004432)2.97865582
7Reticulocytopenia (HP:0001896)2.95089179
8Chromsome breakage (HP:0040012)2.93510424
9Progressive muscle weakness (HP:0003323)2.92229256
10Abnormal mitochondria in muscle tissue (HP:0008316)2.91979936
11Hepatocellular necrosis (HP:0001404)2.90670715
12Abnormal number of erythroid precursors (HP:0012131)2.88840483
13Aplastic anemia (HP:0001915)2.86125401
14Recurrent viral infections (HP:0004429)2.83781138
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.83357015
16Pancytopenia (HP:0001876)2.80149003
17Ragged-red muscle fibers (HP:0003200)2.79711912
18Abnormality of the preputium (HP:0100587)2.77832750
19Abnormality of cells of the erythroid lineage (HP:0012130)2.76980873
20Mitochondrial inheritance (HP:0001427)2.76952625
21Acute necrotizing encephalopathy (HP:0006965)2.76620599
22Increased CSF lactate (HP:0002490)2.74739994
23Oral leukoplakia (HP:0002745)2.71760926
24IgM deficiency (HP:0002850)2.68470791
25Increased serum lactate (HP:0002151)2.67308780
26Combined immunodeficiency (HP:0005387)2.64380162
27Testicular atrophy (HP:0000029)2.59915504
28Abnormality of T cell physiology (HP:0011840)2.58253408
29Premature ovarian failure (HP:0008209)2.56890764
30Abnormal protein glycosylation (HP:0012346)2.56583997
31Abnormal glycosylation (HP:0012345)2.56583997
32Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.56583997
33Abnormal protein N-linked glycosylation (HP:0012347)2.56583997
34Squamous cell carcinoma (HP:0002860)2.54686183
35Hepatic necrosis (HP:0002605)2.52568144
36Myelodysplasia (HP:0002863)2.52345014
37Increased intramyocellular lipid droplets (HP:0012240)2.49480271
38Acute encephalopathy (HP:0006846)2.46641407
39Progressive external ophthalmoplegia (HP:0000590)2.42521984
40B lymphocytopenia (HP:0010976)2.41723844
41Abnormal trabecular bone morphology (HP:0100671)2.39539812
42Multiple enchondromatosis (HP:0005701)2.35689444
43Respiratory difficulties (HP:0002880)2.35072194
44IgG deficiency (HP:0004315)2.34540111
45Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.32324337
46Severe combined immunodeficiency (HP:0004430)2.32076836
47Decreased activity of mitochondrial respiratory chain (HP:0008972)2.31051741
48Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.31051741
49Increased muscle lipid content (HP:0009058)2.27871243
50Exercise intolerance (HP:0003546)2.25603617
51Cerebral hypomyelination (HP:0006808)2.25126871
52Elevated erythrocyte sedimentation rate (HP:0003565)2.25003524
53Aplasia/Hypoplasia of the sacrum (HP:0008517)2.24737012
54Increased hepatocellular lipid droplets (HP:0006565)2.24625261
55Abnormality of glycolysis (HP:0004366)2.22126781
56Abnormal gallbladder physiology (HP:0012438)2.21049658
57Cholecystitis (HP:0001082)2.21049658
58Lactic acidosis (HP:0003128)2.21006232
59Abnormality of T cells (HP:0002843)2.18296817
60Bone marrow hypocellularity (HP:0005528)2.18028570
61Hepatosplenomegaly (HP:0001433)2.16642127
62Lymphoma (HP:0002665)2.15356939
63Birth length less than 3rd percentile (HP:0003561)2.13768517
64Abnormality of the anterior horn cell (HP:0006802)2.13005460
65Degeneration of anterior horn cells (HP:0002398)2.13005460
66Secondary amenorrhea (HP:0000869)2.12291805
67Meckel diverticulum (HP:0002245)2.11629369
68Premature graying of hair (HP:0002216)2.11410406
69Abnormality of B cell number (HP:0010975)2.11267012
70Lipid accumulation in hepatocytes (HP:0006561)2.11174790
71Broad distal phalanx of finger (HP:0009836)2.11039328
72Entropion (HP:0000621)2.10298413
73Increased serum pyruvate (HP:0003542)2.08719619
743-Methylglutaconic aciduria (HP:0003535)2.07671213
75Seborrheic dermatitis (HP:0001051)2.07645325
76Chronic obstructive pulmonary disease (HP:0006510)2.06634028
77Obstructive lung disease (HP:0006536)2.06634028
78Granulocytopenia (HP:0001913)2.05181054
79Recurrent fungal infections (HP:0002841)2.04560830
80Pallor (HP:0000980)2.04270138
81Abnormality of the ileum (HP:0001549)2.02887141
82Duodenal stenosis (HP:0100867)2.02854776
83Small intestinal stenosis (HP:0012848)2.02854776
84Aplasia/Hypoplasia of the thymus (HP:0010515)2.01405469
85Reduced antithrombin III activity (HP:0001976)2.00433844
86Meningitis (HP:0001287)1.99999979
87Progressive macrocephaly (HP:0004481)1.99083741
88Abnormal delayed hypersensitivity skin test (HP:0002963)1.98115091
89Hypertensive crisis (HP:0100735)1.97395321
90Cerebral edema (HP:0002181)1.95770577
91Fatigue (HP:0012378)1.95603185
92Cellular immunodeficiency (HP:0005374)1.93489788
93Cleft eyelid (HP:0000625)1.92836254
94Aplasia/Hypoplasia of the uvula (HP:0010293)1.92571835
95Increased IgM level (HP:0003496)1.91766307
96Basal cell carcinoma (HP:0002671)1.91193145
97Hypergonadotropic hypogonadism (HP:0000815)1.88165631
98Microretrognathia (HP:0000308)1.87767279
99Abnormality of chromosome stability (HP:0003220)1.86834173
100IgA deficiency (HP:0002720)1.84720802

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.87300387
2VRK24.22577681
3NME24.19059902
4TESK23.42642400
5SMG12.81109362
6CDC72.45415580
7SRPK12.35068208
8NEK12.08099840
9MAP4K12.06630920
10EIF2AK11.92521332
11VRK11.91479261
12KDR1.81555160
13PBK1.75342015
14TTK1.73110705
15TSSK61.63643649
16PIM21.59376727
17PLK41.59066953
18SCYL21.57216596
19EIF2AK31.53768939
20BCKDK1.52439991
21IRAK31.49748419
22PDK21.46976345
23ATR1.40788855
24PRPF4B1.36155121
25TAF11.33391880
26TXK1.31514271
27STK161.30362406
28ZAK1.29816436
29STK101.29728952
30CCNB11.27061169
31NME11.26247686
32TESK11.25250205
33WEE11.23111259
34CDK41.19509366
35AURKA1.17878822
36PLK11.16643670
37CDK71.14280863
38AURKB1.10278698
39PASK1.09977813
40MAP3K101.07315143
41CHEK21.05953963
42TLK11.05328602
43TAOK21.01321750
44BRSK10.99269982
45CHEK10.96750919
46ARAF0.95098012
47PAK40.94319867
48NUAK10.94022568
49CDK80.93982353
50DAPK10.93434281
51PLK30.92818683
52MAP3K80.90696659
53MST40.90475998
54IRAK40.89707888
55SIK30.85606771
56MAP3K110.84752061
57MAP3K140.84336577
58RPS6KB20.83191600
59STK40.81734519
60NEK20.79559337
61TBK10.79525424
62EIF2AK20.78664285
63CDK120.75535498
64ERN10.74271708
65MAPK110.73232306
66MAP2K30.71973353
67CLK10.71318210
68MARK30.71021973
69IKBKB0.68425846
70PRKCI0.66504727
71BRAF0.61747097
72TYK20.61175926
73BTK0.58989467
74TRIB30.58223015
75RPS6KA50.56101143
76PIM10.54495651
77PAK10.53846339
78GRK60.49879128
79IKBKE0.49534099
80EEF2K0.47626501
81CDK20.47575001
82CSNK2A20.47381012
83ATM0.46594446
84RPS6KA40.46480627
85CSF1R0.46240647
86CSNK2A10.44604218
87ITK0.44321479
88CDK90.44240319
89BMX0.43271795
90MKNK10.42891850
91RAF10.42872500
92ABL20.42642556
93CDK10.40477922
94ALK0.39967490
95IRAK20.38253229
96SYK0.37234052
97JAK30.37025484
98CDK60.36492080
99TEC0.36462017
100MAPKAPK20.33647012

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.88480557
2Proteasome_Homo sapiens_hsa030504.41794312
3Mismatch repair_Homo sapiens_hsa034303.44555448
4Base excision repair_Homo sapiens_hsa034103.27142656
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.07449012
6Ribosome_Homo sapiens_hsa030102.80681640
7Spliceosome_Homo sapiens_hsa030402.74909602
8Homologous recombination_Homo sapiens_hsa034402.72849945
9RNA polymerase_Homo sapiens_hsa030202.50406163
10Pyrimidine metabolism_Homo sapiens_hsa002402.26729021
11Nucleotide excision repair_Homo sapiens_hsa034202.23379369
12Non-homologous end-joining_Homo sapiens_hsa034502.17769541
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.14744369
14Primary immunodeficiency_Homo sapiens_hsa053402.13456651
15RNA transport_Homo sapiens_hsa030132.10864385
16Cell cycle_Homo sapiens_hsa041102.10627651
17Fanconi anemia pathway_Homo sapiens_hsa034601.82087156
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.56909524
19Parkinsons disease_Homo sapiens_hsa050121.56246468
20One carbon pool by folate_Homo sapiens_hsa006701.53199710
21Sulfur relay system_Homo sapiens_hsa041221.48957217
22Oxidative phosphorylation_Homo sapiens_hsa001901.44739462
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.40905071
24Epstein-Barr virus infection_Homo sapiens_hsa051691.35536811
25RNA degradation_Homo sapiens_hsa030181.22457949
26Antigen processing and presentation_Homo sapiens_hsa046121.19563598
27mRNA surveillance pathway_Homo sapiens_hsa030151.15656172
28Huntingtons disease_Homo sapiens_hsa050161.14940203
29Herpes simplex infection_Homo sapiens_hsa051681.14314002
30Biosynthesis of amino acids_Homo sapiens_hsa012301.13981745
31Purine metabolism_Homo sapiens_hsa002301.11535650
32Allograft rejection_Homo sapiens_hsa053301.11361770
33Basal transcription factors_Homo sapiens_hsa030221.02872180
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01090973
35Asthma_Homo sapiens_hsa053101.00929666
36Autoimmune thyroid disease_Homo sapiens_hsa053201.00764560
37NF-kappa B signaling pathway_Homo sapiens_hsa040640.99721836
38Graft-versus-host disease_Homo sapiens_hsa053320.96672048
39Pentose phosphate pathway_Homo sapiens_hsa000300.95854970
40Intestinal immune network for IgA production_Homo sapiens_hsa046720.94269248
41Cysteine and methionine metabolism_Homo sapiens_hsa002700.93157663
42p53 signaling pathway_Homo sapiens_hsa041150.92796549
43Systemic lupus erythematosus_Homo sapiens_hsa053220.90601348
44Viral carcinogenesis_Homo sapiens_hsa052030.89146806
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.88052328
46RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86831946
47Protein export_Homo sapiens_hsa030600.86018671
48HTLV-I infection_Homo sapiens_hsa051660.84767582
49N-Glycan biosynthesis_Homo sapiens_hsa005100.84647732
50Carbon metabolism_Homo sapiens_hsa012000.82298736
51Measles_Homo sapiens_hsa051620.80700575
52Apoptosis_Homo sapiens_hsa042100.78635468
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75847222
54Shigellosis_Homo sapiens_hsa051310.74774723
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73366400
56Folate biosynthesis_Homo sapiens_hsa007900.71662426
57Fructose and mannose metabolism_Homo sapiens_hsa000510.69594816
58Alzheimers disease_Homo sapiens_hsa050100.69162895
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68013253
60Type I diabetes mellitus_Homo sapiens_hsa049400.67231853
61Viral myocarditis_Homo sapiens_hsa054160.65720306
62Fatty acid elongation_Homo sapiens_hsa000620.65055592
63Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61597643
64Hepatitis B_Homo sapiens_hsa051610.61294892
65Legionellosis_Homo sapiens_hsa051340.59632722
66T cell receptor signaling pathway_Homo sapiens_hsa046600.58620671
67Oocyte meiosis_Homo sapiens_hsa041140.57685097
68Influenza A_Homo sapiens_hsa051640.55318791
69B cell receptor signaling pathway_Homo sapiens_hsa046620.54689281
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53595367
71Acute myeloid leukemia_Homo sapiens_hsa052210.53328931
72Hematopoietic cell lineage_Homo sapiens_hsa046400.53068472
73Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.52709179
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48548429
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.48208302
76Pyruvate metabolism_Homo sapiens_hsa006200.47190886
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46961532
78Cyanoamino acid metabolism_Homo sapiens_hsa004600.46238093
79Glutathione metabolism_Homo sapiens_hsa004800.45316878
80Other glycan degradation_Homo sapiens_hsa005110.45122370
81Leishmaniasis_Homo sapiens_hsa051400.44097056
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38992567
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.38241402
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34946525
85Toll-like receptor signaling pathway_Homo sapiens_hsa046200.34327999
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33989553
87Selenocompound metabolism_Homo sapiens_hsa004500.32804801
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32547420
89Rheumatoid arthritis_Homo sapiens_hsa053230.31943939
90NOD-like receptor signaling pathway_Homo sapiens_hsa046210.31413768
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.31090888
92Bladder cancer_Homo sapiens_hsa052190.30785137
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30708658
94Metabolic pathways_Homo sapiens_hsa011000.30540765
95Osteoclast differentiation_Homo sapiens_hsa043800.27694839
96Galactose metabolism_Homo sapiens_hsa000520.26573124
97Chronic myeloid leukemia_Homo sapiens_hsa052200.25381661
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24704135
99Pancreatic cancer_Homo sapiens_hsa052120.24443577
100Non-small cell lung cancer_Homo sapiens_hsa052230.24340976

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »