DDX39B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the DEAD box family of RNA-dependent ATPases that mediate ATP hydrolysis during pre-mRNA splicing. The encoded protein is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. This gene belongs to a cluster of genes localized in the vicinity of the genes encoding tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. Mutations in this gene may be associated with rheumatoid arthritis. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on both chromosomes 6 and 11. Read-through transcription also occurs between this gene and the upstream ATP6V1G2 (ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2) gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.85526888
2negative regulation of erythrocyte differentiation (GO:0045647)4.81212695
3DNA strand elongation involved in DNA replication (GO:0006271)4.74212798
4negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.67760863
5DNA strand elongation (GO:0022616)4.54940378
6protein localization to kinetochore (GO:0034501)4.42623128
7negative regulation of RNA splicing (GO:0033119)4.25676590
8regulation of histone H3-K27 methylation (GO:0061085)4.22925142
9DNA replication initiation (GO:0006270)4.22357975
10telomere maintenance via semi-conservative replication (GO:0032201)4.14103477
11histone H3-K36 demethylation (GO:0070544)4.11209486
12IMP biosynthetic process (GO:0006188)4.00614699
13formation of translation preinitiation complex (GO:0001731)3.96195955
14mitotic nuclear envelope disassembly (GO:0007077)3.95973824
15mRNA stabilization (GO:0048255)3.93271371
16RNA stabilization (GO:0043489)3.93271371
17negative regulation of mRNA processing (GO:0050686)3.86821932
18DNA replication-dependent nucleosome organization (GO:0034723)3.78600019
19DNA replication-dependent nucleosome assembly (GO:0006335)3.78600019
20DNA duplex unwinding (GO:0032508)3.76991527
21ribosomal small subunit assembly (GO:0000028)3.74899219
22DNA geometric change (GO:0032392)3.73645084
23protein localization to chromosome, centromeric region (GO:0071459)3.71693493
24regulation of RNA export from nucleus (GO:0046831)3.70763539
25membrane disassembly (GO:0030397)3.68778948
26nuclear envelope disassembly (GO:0051081)3.68778948
27mitotic recombination (GO:0006312)3.65843394
28telomere maintenance via recombination (GO:0000722)3.62185053
29nuclear pore organization (GO:0006999)3.60747946
30nucleobase biosynthetic process (GO:0046112)3.59607703
31folic acid-containing compound biosynthetic process (GO:0009396)3.58077333
32sister chromatid segregation (GO:0000819)3.50252256
33histone lysine demethylation (GO:0070076)3.46711770
34mitotic chromosome condensation (GO:0007076)3.46532024
35mitotic sister chromatid segregation (GO:0000070)3.43636875
36DNA replication checkpoint (GO:0000076)3.43184896
37negative regulation of mRNA metabolic process (GO:1903312)3.42093356
38telomere maintenance via telomere lengthening (GO:0010833)3.41715999
39regulation of nucleobase-containing compound transport (GO:0032239)3.41571596
40nuclear pore complex assembly (GO:0051292)3.39948173
41IMP metabolic process (GO:0046040)3.39412758
42mitotic metaphase plate congression (GO:0007080)3.38945162
43embryonic process involved in female pregnancy (GO:0060136)3.38694673
44mannose metabolic process (GO:0006013)3.36777058
45peptidyl-arginine omega-N-methylation (GO:0035247)3.34590414
46* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.33419166
47* mRNA splicing, via spliceosome (GO:0000398)3.33419166
48regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.31536164
49pre-miRNA processing (GO:0031054)3.30860908
50* RNA splicing, via transesterification reactions (GO:0000375)3.29410370
51nucleotide-excision repair, DNA gap filling (GO:0006297)3.28426770
52regulation of NFAT protein import into nucleus (GO:0051532)3.28246277
53dosage compensation (GO:0007549)3.28056475
54histone demethylation (GO:0016577)3.27175681
55maturation of SSU-rRNA (GO:0030490)3.26316403
56histone H2A acetylation (GO:0043968)3.25306412
57negative regulation of histone methylation (GO:0031061)3.22629261
58positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.22055876
59regulation of spindle organization (GO:0090224)3.20319898
60cell-substrate adherens junction assembly (GO:0007045)3.18980988
61focal adhesion assembly (GO:0048041)3.18980988
62viral transcription (GO:0019083)3.17994618
63adherens junction assembly (GO:0034333)3.15739297
64translesion synthesis (GO:0019985)3.15318113
65termination of RNA polymerase II transcription (GO:0006369)3.14181670
66DNA topological change (GO:0006265)3.13416171
67regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.11920706
68regulation of mammary gland epithelial cell proliferation (GO:0033599)3.11456387
69apoptotic process involved in morphogenesis (GO:0060561)3.10189606
70protein-DNA complex disassembly (GO:0032986)3.09973453
71nucleosome disassembly (GO:0006337)3.09973453
72positive regulation of gamma-delta T cell activation (GO:0046645)3.07850575
73translational termination (GO:0006415)3.07820408
74metaphase plate congression (GO:0051310)3.07659738
75DNA conformation change (GO:0071103)3.06149526
76DNA replication-independent nucleosome assembly (GO:0006336)3.05965917
77DNA replication-independent nucleosome organization (GO:0034724)3.05965917
78regulation of translational fidelity (GO:0006450)3.05872420
79purine nucleobase biosynthetic process (GO:0009113)3.04991724
80cellular response to epidermal growth factor stimulus (GO:0071364)3.04836906
81regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.04830820
82response to muramyl dipeptide (GO:0032495)3.04616434
83postreplication repair (GO:0006301)3.02290656
84regulation of somitogenesis (GO:0014807)3.01769145
85translational elongation (GO:0006414)3.01492304
86histone H3-K9 demethylation (GO:0033169)3.00465654
87heterochromatin organization (GO:0070828)3.00198022
88peptidyl-arginine methylation (GO:0018216)2.99117011
89peptidyl-arginine N-methylation (GO:0035246)2.99117011
90response to laminar fluid shear stress (GO:0034616)2.98806832
91somatic hypermutation of immunoglobulin genes (GO:0016446)2.98533495
92somatic diversification of immune receptors via somatic mutation (GO:0002566)2.98533495
93translational initiation (GO:0006413)2.98340410
94positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.96448844
95regulation of chromatin binding (GO:0035561)2.96113010
96nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.95446732
97negative regulation of myotube differentiation (GO:0010832)2.94740101
98ATP-dependent chromatin remodeling (GO:0043044)2.94501587
99base-excision repair (GO:0006284)2.94269372
100nuclear envelope organization (GO:0006998)2.93357451
101regulation of mRNA stability (GO:0043488)2.93278422
102regulation of histone H3-K9 methylation (GO:0051570)2.92651962
103chromatin assembly or disassembly (GO:0006333)2.92341388
104negative regulation of chromosome segregation (GO:0051985)2.91568998
105intracellular estrogen receptor signaling pathway (GO:0030520)2.91041504
106alternative mRNA splicing, via spliceosome (GO:0000380)2.90919198
107establishment of chromosome localization (GO:0051303)2.90224116
108pore complex assembly (GO:0046931)2.90100689
109spliceosomal tri-snRNP complex assembly (GO:0000244)2.88998697
110negative regulation of mitotic sister chromatid separation (GO:2000816)2.87186921
111negative regulation of mitotic sister chromatid segregation (GO:0033048)2.87186921
112negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.87186921
113negative regulation of sister chromatid segregation (GO:0033046)2.87186921
114spliceosomal snRNP assembly (GO:0000387)2.87101735
115mitotic spindle assembly checkpoint (GO:0007094)2.86381527
116protein dealkylation (GO:0008214)2.85435970
117protein demethylation (GO:0006482)2.85435970
118regulation of sister chromatid cohesion (GO:0007063)2.85433907
119CENP-A containing nucleosome assembly (GO:0034080)2.85384337
120spindle assembly checkpoint (GO:0071173)2.85328851
1213-UTR-mediated mRNA stabilization (GO:0070935)2.84216968
122regulation of chromosome segregation (GO:0051983)2.83342749
123peptidyl-lysine dimethylation (GO:0018027)2.83118525
124kinetochore organization (GO:0051383)2.83034503
125chromatin remodeling at centromere (GO:0031055)2.82982613
126cellular hyperosmotic response (GO:0071474)2.82813643
127maternal placenta development (GO:0001893)2.82606012
128positive regulation of chromosome segregation (GO:0051984)2.81886494
129response to epidermal growth factor (GO:0070849)2.81537735
130mismatch repair (GO:0006298)2.80777932
131regulation of RNA stability (GO:0043487)2.80584274
132histone arginine methylation (GO:0034969)2.80275008
133protein localization to chromosome (GO:0034502)2.80051980
134ribosome biogenesis (GO:0042254)2.79247555
135regulation of mitotic spindle organization (GO:0060236)2.77246129
136snRNA processing (GO:0016180)2.77238874
137thymic T cell selection (GO:0045061)2.76697217
138antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.75432353
139trophectodermal cell differentiation (GO:0001829)2.71748109
140antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.70374223
141protein export from nucleus (GO:0006611)2.67676210
142planar cell polarity pathway involved in neural tube closure (GO:0090179)2.63529309
143regulation of gamma-delta T cell differentiation (GO:0045586)2.61200308
144COPI coating of Golgi vesicle (GO:0048205)2.60669573
145Golgi transport vesicle coating (GO:0048200)2.60669573
146epithelial cell differentiation involved in prostate gland development (GO:0060742)2.58143176
147histone H4 deacetylation (GO:0070933)2.55518618
148regulation of gamma-delta T cell activation (GO:0046643)2.54723677
149poly(A)+ mRNA export from nucleus (GO:0016973)2.53602306
150activation of Rac GTPase activity (GO:0032863)2.51859973
151histone H3-K4 methylation (GO:0051568)2.51206009
152stress granule assembly (GO:0034063)2.49911899
153positive thymic T cell selection (GO:0045059)2.49110544
154antigen processing and presentation of endogenous antigen (GO:0019883)2.48015980
155positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.47194187
156positive regulation of RNA splicing (GO:0033120)2.46784452
157regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.45519496
158histone H4-K16 acetylation (GO:0043984)2.44419479
159glucocorticoid receptor signaling pathway (GO:0042921)2.42064462
160regulation of necroptotic process (GO:0060544)2.41640634
161negative regulation of cell killing (GO:0031342)2.39574907
162negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.39574907
163positive regulation by symbiont of host defense response (GO:0052509)2.38663763
164modulation by symbiont of host defense response (GO:0052031)2.38663763
165modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.38663763
166modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.38663763
167positive regulation by organism of defense response of other organism involved in symbiotic interact2.38663763
168modulation by symbiont of host immune response (GO:0052553)2.38663763
169regulation of glucose import in response to insulin stimulus (GO:2001273)2.37643315
170modulation by virus of host process (GO:0019054)2.37607391
171cellular protein complex localization (GO:0034629)2.35970372
172positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.33170121
173negative thymic T cell selection (GO:0045060)2.32974502
174cellular response to interleukin-4 (GO:0071353)2.31961110
175histone H3 deacetylation (GO:0070932)2.28104258
176negative regulation of viral release from host cell (GO:1902187)2.28070040
177snRNA metabolic process (GO:0016073)2.27845788
178modulation by symbiont of host cellular process (GO:0044068)2.26538050
179cell-substrate junction assembly (GO:0007044)2.25821826

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.98165619
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.57509718
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.72933909
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.69193602
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.43965986
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.00201414
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.99672686
8MYC_22102868_ChIP-Seq_BL_Human2.97169077
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.78956347
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.45231871
11KDM2B_26808549_Chip-Seq_SUP-B15_Human2.43330153
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.36415440
13CIITA_25753668_ChIP-Seq_RAJI_Human2.33166835
14XRN2_22483619_ChIP-Seq_HELA_Human2.31764136
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.19581238
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.12357185
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.08189113
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.04840685
19LXR_22292898_ChIP-Seq_THP-1_Human2.02357159
20E2F1_21310950_ChIP-Seq_MCF-7_Human1.97560931
21STAT6_21828071_ChIP-Seq_BEAS2B_Human1.97127087
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.96876055
23VDR_21846776_ChIP-Seq_THP-1_Human1.92797794
24AR_21909140_ChIP-Seq_LNCAP_Human1.80571673
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.80314737
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.80295575
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.79831418
28RACK7_27058665_Chip-Seq_MCF-7_Human1.76703114
29CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.76146821
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.75662490
31KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.73833915
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.73787705
33KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.73750046
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.72783093
35CLOCK_20551151_ChIP-Seq_293T_Human1.67401921
36KDM2B_26808549_Chip-Seq_JURKAT_Human1.67045617
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.66890540
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.66057045
39TP63_17297297_ChIP-ChIP_HaCaT_Human1.66044479
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.65579089
41FOXP3_21729870_ChIP-Seq_TREG_Human1.64812598
42VDR_23849224_ChIP-Seq_CD4+_Human1.64521468
43GABP_17652178_ChIP-ChIP_JURKAT_Human1.63740801
44ELF1_17652178_ChIP-ChIP_JURKAT_Human1.61761046
45TTF2_22483619_ChIP-Seq_HELA_Human1.61553958
46GABP_19822575_ChIP-Seq_HepG2_Human1.61486901
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.60983296
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.58616256
49TP63_19390658_ChIP-ChIP_HaCaT_Human1.57923087
50* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.56760533
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.56474621
52CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.55004956
53* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54573268
54KDM2B_26808549_Chip-Seq_K562_Human1.54303892
55E2F1_18555785_ChIP-Seq_MESCs_Mouse1.53534758
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52008394
57KDM5A_27292631_Chip-Seq_BREAST_Human1.51787235
58KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.47624801
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45904624
60* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.44639110
61DCP1A_22483619_ChIP-Seq_HELA_Human1.44566710
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.44033782
63TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43429245
64CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.42655830
65NCOR1_26117541_ChIP-Seq_K562_Human1.41850177
66BRD4_27068464_Chip-Seq_AML-cells_Mouse1.39758509
67TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.38942499
68KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.38558087
69ZFP281_27345836_Chip-Seq_ESCs_Mouse1.37579336
70ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.36022732
71RUNX1_22412390_ChIP-Seq_EML_Mouse1.35940334
72WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.35464685
73MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.32679939
74P300_27058665_Chip-Seq_ZR-75-30cells_Human1.32575671
75RARG_19884340_ChIP-ChIP_MEFs_Mouse1.31558554
76E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.29096031
77ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27822061
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27607503
79CTCF_27219007_Chip-Seq_ERYTHROID_Human1.27519687
80DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.27237442
81SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26668138
82SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.25955469
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.24634212
84POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21590513
85TCF7_22412390_ChIP-Seq_EML_Mouse1.21437667
86KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20255134
87RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.19993408
88MYB_26560356_Chip-Seq_TH1_Human1.19774319
89YY1_21170310_ChIP-Seq_MESCs_Mouse1.18038276
90CREB1_26743006_Chip-Seq_LNCaP_Human1.17676868
91UTX_26944678_Chip-Seq_JUKART_Human1.16521868
92EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.15974495
93HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15579001
94RUNX1_27514584_Chip-Seq_MCF-7_Human1.15418099
95KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.15366363
96SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15186940
97TFEB_21752829_ChIP-Seq_HELA_Human1.15062718
98MYB_21317192_ChIP-Seq_ERMYB_Mouse1.15026473
99E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14123199
100GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12941903
101DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.12629678
102* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.12381165
103SA1_27219007_Chip-Seq_ERYTHROID_Human1.11829643
104CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.11438076
105CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11426944
106NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11423163
107SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.10399389
108ZNF263_19887448_ChIP-Seq_K562_Human1.10256691
109FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.09873931
110MAF_26560356_Chip-Seq_TH1_Human1.09795943
111NANOG_21062744_ChIP-ChIP_HESCs_Human1.09456837
112SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07364229
113STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06449153
114ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06091015
115VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05887450
116ELK3_25401928_ChIP-Seq_HUVEC_Human1.04173066
117TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03973311
118PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.03953559
119SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.03569614
120UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03553595
121P68_20966046_ChIP-Seq_HELA_Human1.03452880
122KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.03285268
123KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.03285268
124KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.03285268
125KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03165624
126KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02138901
127TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01593982
128STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.01201592
129POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01037414
130ELK1_19687146_ChIP-ChIP_HELA_Human1.01003470
131CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00615910
132SMC4_20622854_ChIP-Seq_HELA_Human1.00335613
133FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.00197327
134PKCTHETA_26484144_Chip-Seq_BREAST_Human0.99073367
135KDM2B_26808549_Chip-Seq_DND41_Human0.98853785
136GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98713798
137SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.98170086
138KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98091995
139TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.97892814
140HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.97199223
141TET1_21451524_ChIP-Seq_MESCs_Mouse0.94321007
142RBPJ_22232070_ChIP-Seq_NCS_Mouse0.93052534
143ZFP281_18757296_ChIP-ChIP_E14_Mouse0.91902625
144CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90633775
145MAF_26560356_Chip-Seq_TH2_Human0.88005099
146BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87639978
147PADI4_21655091_ChIP-ChIP_MCF-7_Human0.87207694
148SPI1_23547873_ChIP-Seq_NB4_Human0.85959694
149CHD1_26751641_Chip-Seq_LNCaP_Human0.85513412
150VDR_24763502_ChIP-Seq_THP-1_Human0.82727715
151TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82428485
152MYB_26560356_Chip-Seq_TH2_Human0.81219796
153SCL_19346495_ChIP-Seq_HPC-7_Human0.81113896

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.12172379
2MP0010094_abnormal_chromosome_stability4.05328790
3MP0003111_abnormal_nucleus_morphology4.03597830
4MP0004957_abnormal_blastocyst_morpholog3.66687948
5MP0003077_abnormal_cell_cycle3.62054331
6MP0008057_abnormal_DNA_replication3.11160954
7MP0008007_abnormal_cellular_replicative2.73858304
8MP0002009_preneoplasia2.73815091
9MP0002396_abnormal_hematopoietic_system2.60343603
10MP0003123_paternal_imprinting2.60061768
11MP0008058_abnormal_DNA_repair2.58952415
12MP0010352_gastrointestinal_tract_polyps2.51457591
13MP0001730_embryonic_growth_arrest2.37705971
14MP0000350_abnormal_cell_proliferation2.24459904
15MP0008932_abnormal_embryonic_tissue2.09606224
16MP0005076_abnormal_cell_differentiation2.06554385
17MP0004185_abnormal_adipocyte_glucose2.05792514
18MP0004808_abnormal_hematopoietic_stem2.03583144
19MP0000537_abnormal_urethra_morphology1.98400670
20MP0010030_abnormal_orbit_morphology1.97988261
21MP0003436_decreased_susceptibility_to1.94732827
22MP0005409_darkened_coat_color1.92495894
23MP0003121_genomic_imprinting1.83525981
24MP0005380_embryogenesis_phenotype1.83107206
25MP0001672_abnormal_embryogenesis/_devel1.83107206
26MP0009278_abnormal_bone_marrow1.82441004
27MP0001697_abnormal_embryo_size1.79979598
28MP0005451_abnormal_body_composition1.77221003
29MP0008260_abnormal_autophagy1.76550773
30MP0002085_abnormal_embryonic_tissue1.73474196
31MP0004197_abnormal_fetal_growth/weight/1.73394226
32MP0003300_gastrointestinal_ulcer1.71520464
33MP0003984_embryonic_growth_retardation1.71312072
34MP0002080_prenatal_lethality1.70108917
35MP0002084_abnormal_developmental_patter1.69447500
36MP0002088_abnormal_embryonic_growth/wei1.68030946
37MP0010307_abnormal_tumor_latency1.66182555
38MP0003763_abnormal_thymus_physiology1.61485971
39MP0001873_stomach_inflammation1.59596322
40MP0003567_abnormal_fetal_cardiomyocyte1.57199954
41MP0000490_abnormal_crypts_of1.53938719
42MP0002653_abnormal_ependyma_morphology1.52714882
43MP0002877_abnormal_melanocyte_morpholog1.52626135
44MP0005666_abnormal_adipose_tissue1.50095099
45MP0002086_abnormal_extraembryonic_tissu1.49722969
46MP0000703_abnormal_thymus_morphology1.48978711
47MP0008877_abnormal_DNA_methylation1.47137632
48MP0003705_abnormal_hypodermis_morpholog1.44924319
49MP0010630_abnormal_cardiac_muscle1.44514120
50MP0003091_abnormal_cell_migration1.43928960
51MP0006054_spinal_hemorrhage1.43567648
52MP0000313_abnormal_cell_death1.42649582
53MP0009053_abnormal_anal_canal1.42197842
54MP0002019_abnormal_tumor_incidence1.35832493
55MP0002249_abnormal_larynx_morphology1.35523915
56MP0001545_abnormal_hematopoietic_system1.34967843
57MP0005397_hematopoietic_system_phenotyp1.34967843
58MP0003303_peritoneal_inflammation1.32447120
59MP0001293_anophthalmia1.32294686
60MP0001849_ear_inflammation1.31934053
61MP0003119_abnormal_digestive_system1.31031845
62MP0003890_abnormal_embryonic-extraembry1.30190576
63MP0004858_abnormal_nervous_system1.29530545
64MP0003221_abnormal_cardiomyocyte_apopto1.26659843
65MP0002398_abnormal_bone_marrow1.25525200
66MP0005375_adipose_tissue_phenotype1.25251185
67MP0002166_altered_tumor_susceptibility1.24186083
68MP0009672_abnormal_birth_weight1.21991928
69MP0001348_abnormal_lacrimal_gland1.20884378
70MP0003183_abnormal_peptide_metabolism1.20418719
71MP0000003_abnormal_adipose_tissue1.18422662
72MP0009333_abnormal_splenocyte_physiolog1.17831483
73MP0000428_abnormal_craniofacial_morphol1.16875976
74MP0000751_myopathy1.15855763
75MP0003786_premature_aging1.14547420
76MP0004947_skin_inflammation1.13665912
77MP0001800_abnormal_humoral_immune1.11924691
78MP0002722_abnormal_immune_system1.09077017
79MP0003115_abnormal_respiratory_system1.08876295
80MP0003122_maternal_imprinting1.08318439
81MP0004087_abnormal_muscle_fiber1.07745015
82MP0003453_abnormal_keratinocyte_physiol1.05588884
83MP0003172_abnormal_lysosome_physiology1.00802729
84MP0003315_abnormal_perineum_morphology0.99476538
85MP0000689_abnormal_spleen_morphology0.97687470
86MP0000733_abnormal_muscle_development0.97287072
87MP0002111_abnormal_tail_morphology0.97044293
88MP0004233_abnormal_muscle_weight0.96071911
89MP0003828_pulmonary_edema0.95501042
90MP0002405_respiratory_system_inflammati0.94209617
91MP0003942_abnormal_urinary_system0.93303749
92MP0001915_intracranial_hemorrhage0.93299598
93MP0006138_congestive_heart_failure0.93267263
94MP0008961_abnormal_basal_metabolism0.92692103
95MP0009703_decreased_birth_body0.91741173
96MP0002429_abnormal_blood_cell0.90378748
97MP0003935_abnormal_craniofacial_develop0.88387486
98MP0003283_abnormal_digestive_organ0.88312631
99MP0004510_myositis0.87984562
100MP0004381_abnormal_hair_follicle0.87905838
101MP0001346_abnormal_lacrimal_gland0.86667159
102MP0002420_abnormal_adaptive_immunity0.85952766
103MP0004133_heterotaxia0.85027668
104MP0002932_abnormal_joint_morphology0.84879304
105MP0005058_abnormal_lysosome_morphology0.84670705
106MP0001819_abnormal_immune_cell0.84535439
107MP0001835_abnormal_antigen_presentation0.84487293
108MP0001661_extended_life_span0.83933728
109MP0002092_abnormal_eye_morphology0.83476122
110MP0000759_abnormal_skeletal_muscle0.83093435
111MP0003566_abnormal_cell_adhesion0.83060219
112MP0002925_abnormal_cardiovascular_devel0.82985077
113MP0002089_abnormal_postnatal_growth/wei0.81964417
114MP0000049_abnormal_middle_ear0.80598060
115MP0005023_abnormal_wound_healing0.79932624
116MP0002933_joint_inflammation0.79436475
117MP0003787_abnormal_imprinting0.78885131
118MP0005384_cellular_phenotype0.78372031
119MP0000716_abnormal_immune_system0.78338013
120MP0000477_abnormal_intestine_morphology0.77281928
121MP0001851_eye_inflammation0.77048598
122MP0000858_altered_metastatic_potential0.75311255
123MP0010155_abnormal_intestine_physiology0.75169524
124MP0005000_abnormal_immune_tolerance0.75105096
125MP0003861_abnormal_nervous_system0.73590309
126MP0002210_abnormal_sex_determination0.73564348
127MP0005621_abnormal_cell_physiology0.73223573
128MP0000678_abnormal_parathyroid_gland0.71599553
129MP0000534_abnormal_ureter_morphology0.70057539
130MP0000358_abnormal_cell_content/0.68610676
131MP0000685_abnormal_immune_system0.68337580
132MP0000266_abnormal_heart_morphology0.67813684
133MP0008789_abnormal_olfactory_epithelium0.67432740
134MP0000465_gastrointestinal_hemorrhage0.67396005
135MP0003385_abnormal_body_wall0.67353912
136MP0008770_decreased_survivor_rate0.67326729
137MP0001145_abnormal_male_reproductive0.66724494
138MP0004264_abnormal_extraembryonic_tissu0.66214316
139MP0002114_abnormal_axial_skeleton0.65591362
140MP0002938_white_spotting0.65197024
141MP0001286_abnormal_eye_development0.65107852
142MP0003943_abnormal_hepatobiliary_system0.64829253
143MP0002697_abnormal_eye_size0.63572767
144MP0000432_abnormal_head_morphology0.62416105

Predicted human phenotypes

RankGene SetZ-score
1Colon cancer (HP:0003003)3.69054358
2Ependymoma (HP:0002888)3.66591567
3Short 4th metacarpal (HP:0010044)3.50406067
4Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.50406067
5Medulloblastoma (HP:0002885)3.40538164
6Selective tooth agenesis (HP:0001592)3.34851162
7Hyperacusis (HP:0010780)3.32836531
8Renal duplication (HP:0000075)3.15528538
9Increased nuchal translucency (HP:0010880)3.09744033
10Slow saccadic eye movements (HP:0000514)3.05593836
11Flat acetabular roof (HP:0003180)3.05339753
12Patellar aplasia (HP:0006443)2.78061931
13Abnormal number of incisors (HP:0011064)2.76781215
14Vertebral arch anomaly (HP:0008438)2.75713181
15Birth length less than 3rd percentile (HP:0003561)2.75547771
16Broad face (HP:0000283)2.73055724
17Abnormality of the 4th metacarpal (HP:0010012)2.66359595
18Obstructive sleep apnea (HP:0002870)2.65236516
19Aplasia/Hypoplasia of the patella (HP:0006498)2.64396900
20Degeneration of anterior horn cells (HP:0002398)2.61185615
21Abnormality of the anterior horn cell (HP:0006802)2.61185615
22Reticulocytopenia (HP:0001896)2.59020220
23Basal cell carcinoma (HP:0002671)2.55371692
24Sparse lateral eyebrow (HP:0005338)2.54047229
25Astrocytoma (HP:0009592)2.50760568
26Abnormality of the astrocytes (HP:0100707)2.50760568
27Abnormality of the fingertips (HP:0001211)2.46661974
28Neonatal hypoglycemia (HP:0001998)2.46431676
29Asymmetry of the thorax (HP:0001555)2.45417848
30Syringomyelia (HP:0003396)2.42600027
31Spinal cord lesions (HP:0100561)2.42600027
32Disproportionate tall stature (HP:0001519)2.39398300
33Eczematoid dermatitis (HP:0000976)2.37386827
34Neoplasm of the pancreas (HP:0002894)2.35278815
35Broad palm (HP:0001169)2.35056107
36Proximal placement of thumb (HP:0009623)2.34799702
37Metaphyseal cupping (HP:0003021)2.32974810
38Cellulitis (HP:0100658)2.29250103
39Ankyloglossia (HP:0010296)2.28334086
40Abnormality of cells of the erythroid lineage (HP:0012130)2.27880905
41Oral leukoplakia (HP:0002745)2.27123945
42Deviation of the thumb (HP:0009603)2.26256304
43Dysmetric saccades (HP:0000641)2.26041518
44Abnormal number of erythroid precursors (HP:0012131)2.25825652
45Dislocated radial head (HP:0003083)2.24100422
46Colitis (HP:0002583)2.23846570
47Long eyelashes (HP:0000527)2.18692582
48Elfin facies (HP:0004428)2.17196741
49Cerebral aneurysm (HP:0004944)2.15714170
50Skin tags (HP:0010609)2.14920097
51Renovascular hypertension (HP:0100817)2.14652736
52Urethral obstruction (HP:0000796)2.14428330
53Atresia of the external auditory canal (HP:0000413)2.14358055
54High pitched voice (HP:0001620)2.12686710
55Overriding aorta (HP:0002623)2.11851626
56Abnormality of the distal phalanx of the thumb (HP:0009617)2.09563636
57Trigonocephaly (HP:0000243)2.09229282
58Glioma (HP:0009733)2.09204959
59Myelodysplasia (HP:0002863)2.07921276
60Aplastic anemia (HP:0001915)2.07048215
61Neoplasm of the oral cavity (HP:0100649)2.07027237
62Abnormality of the thoracic spine (HP:0100711)2.06915782
63Agnosia (HP:0010524)2.06714051
64Preauricular skin tag (HP:0000384)2.06046265
65Abnormality of the radial head (HP:0003995)2.04260085
66Abnormal lung lobation (HP:0002101)2.03595746
67Rhabdomyosarcoma (HP:0002859)2.03550615
68Missing ribs (HP:0000921)2.02022726
69Deep venous thrombosis (HP:0002625)2.01991232
70Optic nerve coloboma (HP:0000588)2.01506060
71Abnormality of the columella (HP:0009929)2.01445457
72Diastasis recti (HP:0001540)2.00048420
73Distal lower limb amyotrophy (HP:0008944)1.99388504
74Overlapping toe (HP:0001845)1.99341747
75Thrombocytosis (HP:0001894)1.99172768
76Neoplasm of striated muscle (HP:0009728)1.98393816
77Hemorrhage of the eye (HP:0011885)1.98121096
78Aplasia/Hypoplasia of the sternum (HP:0006714)1.96811665
79Abnormality of the lumbar spine (HP:0100712)1.96359132
80Pointed chin (HP:0000307)1.96114864
81Meckel diverticulum (HP:0002245)1.94621167
82Progressive external ophthalmoplegia (HP:0000590)1.94306980
8311 pairs of ribs (HP:0000878)1.94287916
84Amaurosis fugax (HP:0100576)1.93501653
85Shallow orbits (HP:0000586)1.92082043
86Cafe-au-lait spot (HP:0000957)1.91837993
87Tracheoesophageal fistula (HP:0002575)1.90840425
88Increased density of long bones (HP:0006392)1.90340810
89Thoracic kyphosis (HP:0002942)1.90243191
90Subacute progressive viral hepatitis (HP:0006572)1.89207635
91Prominent nose (HP:0000448)1.88915284
92Carpal bone hypoplasia (HP:0001498)1.88261162
93Malignant gastrointestinal tract tumors (HP:0006749)1.88132051
94Gastrointestinal carcinoma (HP:0002672)1.88132051
95Short 5th finger (HP:0009237)1.87911418
96Abnormality of the ileum (HP:0001549)1.87782455
97Ulnar bowing (HP:0003031)1.87610853
98Ectopic kidney (HP:0000086)1.87475695
99Viral hepatitis (HP:0006562)1.87268107
100Bowel diverticulosis (HP:0005222)1.87015542
101Protrusio acetabuli (HP:0003179)1.86909209
102Insomnia (HP:0100785)1.86601886
103Abnormality of the calcaneus (HP:0008364)1.85962784
104Volvulus (HP:0002580)1.85581552
105Breast hypoplasia (HP:0003187)1.84970950
106Thin ribs (HP:0000883)1.84804372
107Centrally nucleated skeletal muscle fibers (HP:0003687)1.84024586
108Persistence of primary teeth (HP:0006335)1.83764872
109Abnormality of oral frenula (HP:0000190)1.83483248
110Cellular immunodeficiency (HP:0005374)1.82550266
111Premature graying of hair (HP:0002216)1.80120227
112Bicuspid aortic valve (HP:0001647)1.79533122
113Adenoma sebaceum (HP:0009720)1.79168425
114Angiofibromas (HP:0010615)1.79168425
115Broad thumb (HP:0011304)1.78725578
116Slender long bone (HP:0003100)1.78363515
117Intestinal polyp (HP:0005266)1.77746125
118Abnormality of the metopic suture (HP:0005556)1.76520420
119Increased connective tissue (HP:0009025)1.74896981
120Prominent metopic ridge (HP:0005487)1.74715582
121Chromsome breakage (HP:0040012)1.74353342
122Cutis marmorata (HP:0000965)1.74301177
123Rough bone trabeculation (HP:0100670)1.73819103
124Abnormality of the carotid arteries (HP:0005344)1.73762409
125Gastrointestinal inflammation (HP:0004386)1.73621762
126Lip pit (HP:0100267)1.72272904
127Neoplasm of the colon (HP:0100273)1.71084308
128Broad phalanges of the hand (HP:0009768)1.70976700
129Duodenal stenosis (HP:0100867)1.70316435
130Small intestinal stenosis (HP:0012848)1.70316435
131Increased IgE level (HP:0003212)1.69855768
132Ovarian neoplasm (HP:0100615)1.69690496
133Atrophy/Degeneration involving motor neurons (HP:0007373)1.69681283
134Acute lymphatic leukemia (HP:0006721)1.68624660
135Abnormality of chromosome stability (HP:0003220)1.68201396
136Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.68180317
137Freckling (HP:0001480)1.67924779
138Anal stenosis (HP:0002025)1.67869658
139Flat cornea (HP:0007720)1.67625415
140Progressive muscle weakness (HP:0003323)1.67393307
141Lymphoma (HP:0002665)1.67353502
142Megalocornea (HP:0000485)1.66857605
143Long palpebral fissure (HP:0000637)1.66654233
144Abnormality of the intervertebral disk (HP:0005108)1.66456136
145Intestinal polyposis (HP:0200008)1.66274168
146Biconcave vertebral bodies (HP:0004586)1.66150018
147Pelvic girdle muscle weakness (HP:0003749)1.65887281
148Heterotopia (HP:0002282)1.65437824
149Mitral valve prolapse (HP:0001634)1.64207940
150Abnormal delayed hypersensitivity skin test (HP:0002963)1.62832117
151Germ cell neoplasia (HP:0100728)1.62549080
152Narrow palate (HP:0000189)1.62167937
153Segmental peripheral demyelination/remyelination (HP:0003481)1.61797889
154Anomalous pulmonary venous return (HP:0010772)1.61438185
155Aneurysm (HP:0002617)1.59852536
156Spina bifida occulta (HP:0003298)1.59592403
157Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.59000995
158Rectal prolapse (HP:0002035)1.58743636
159Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.58520042
160Reticulocytosis (HP:0001923)1.58198046
161Flared metaphyses (HP:0003015)1.56002888
162Deep philtrum (HP:0002002)1.55982779
163J-shaped sella turcica (HP:0002680)1.55374123
164Recurrent viral infections (HP:0004429)1.55050754
165Uterine leiomyosarcoma (HP:0002891)1.54426322
166Leiomyosarcoma (HP:0100243)1.54426322
167Premature skin wrinkling (HP:0100678)1.54120356
168Supernumerary ribs (HP:0005815)1.53975272
169Abnormality of the humeroradial joint (HP:0100744)1.52416185
170Fatigue (HP:0012378)1.52182779
171Deep palmar crease (HP:0006191)1.50374985
172Agammaglobulinemia (HP:0004432)1.50282864
173Chin dimple (HP:0010751)1.49689263
174Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.48673606
175Thin bony cortex (HP:0002753)1.48476121
176High anterior hairline (HP:0009890)1.47812465
177Polygenic inheritance (HP:0010982)1.47061346
178Inflammation of the large intestine (HP:0002037)1.46710366
179Arnold-Chiari malformation (HP:0002308)1.46594535
180Macroorchidism (HP:0000053)1.45987682
181Advanced eruption of teeth (HP:0006288)1.45440338
182Deformed sella turcica (HP:0002681)1.44508405
183Pseudobulbar signs (HP:0002200)1.44310383
184Abnormality of the salivary glands (HP:0010286)1.43962932
185Dilatation of the ascending aorta (HP:0005111)1.43575737
186Seborrheic dermatitis (HP:0001051)1.41974144

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.14363399
2PRPF4B3.75022248
3EEF2K3.53441579
4MAP3K103.32782012
5SMG13.31773261
6BUB13.30165847
7WEE12.93504903
8BLK2.91994047
9NEK22.68864696
10PKN22.58204207
11PASK2.56599889
12TSSK62.51021080
13FGFR42.43565258
14CDK122.40000386
15TRIB32.35016021
16NEK12.08667970
17TESK21.95343038
18SIK11.87697281
19RPS6KB21.85169644
20MKNK11.84960602
21TGFBR11.76529836
22ATR1.75548169
23TTK1.75291701
24MAP4K11.73228258
25SRPK11.64539397
26CDK71.61592517
27PAK41.59137519
28STK101.53912791
29CDK41.47142115
30PLK11.46523469
31RPS6KA41.41914438
32BRSK21.39549868
33ACVR1B1.38209509
34BRD41.37046300
35MAP3K131.36964378
36SCYL21.35961973
37BRSK11.34181168
38MAP3K81.33487577
39EIF2AK11.31214202
40AURKB1.31095393
41KSR21.29372653
42MAP3K61.28199378
43RIPK41.28151901
44MKNK21.27811973
45ALK1.25464013
46LRRK21.21678215
47CHEK11.21133702
48MARK21.13032328
49MAP3K71.12426305
50FGFR31.11879336
51CDC42BPA1.10204217
52PLK31.07330084
53FLT31.06800305
54DYRK31.05641219
55CAMK1D1.05086700
56MAP3K141.01540530
57CCNB11.01424981
58RET1.00207906
59TYK20.96539154
60TYRO30.94745184
61TLK10.94737127
62CHEK20.94571614
63PTK60.93613495
64CDK60.93021329
65CDK20.92024094
66STK40.90520083
67MTOR0.88969868
68VRK10.88384260
69ERN10.86764228
70CLK10.86349200
71EPHB10.86022210
72TESK10.85456931
73IRAK40.84905590
74AURKA0.84074752
75HIPK20.83834716
76PLK40.83767394
77BTK0.82153185
78ATM0.79524471
79GRK60.79008464
80SIK30.76048061
81ZAP700.75361142
82MAP2K30.74684101
83TTN0.72161879
84IRAK30.71113714
85PDGFRA0.70397840
86ILK0.70347928
87FGFR10.69869699
88BMX0.69167230
89PIM10.67776102
90PDGFRB0.66395159
91CDK10.64054964
92CAMK1G0.62253265
93EIF2AK30.62038841
94ICK0.60750799
95PAK10.58238495
96MAPK120.56953778
97DAPK10.56929319
98CAMKK10.56033941
99PDPK10.55941541
100CSK0.55928906
101CAMK40.55635942
102YES10.54653229
103HCK0.54547703
104CDK90.54432881
105PAK20.54298536
106LATS20.51813759
107SGK30.51177616
108MELK0.50249385
109AKT20.49740505
110KDR0.49100177
111FGFR20.47904737
112JAK20.47533939
113RPS6KL10.47442409
114RPS6KC10.47442409
115CSNK2A20.47128503
116SIK20.47084022
117CSF1R0.46238772
118MAP3K10.45829011
119PDK10.45808543
120WNK10.45099474
121MAPK70.45082882
122RPS6KA60.44731892
123MAP3K30.44727496
124CDK80.44671481
125DYRK1B0.44033247
126MAPK110.43675102
127JAK30.43559461
128MAPKAPK30.43067755
129SYK0.41589944
130PRKDC0.41325553
131MAP3K20.40739876
132RPS6KA10.40429772
133JAK10.40212829
134IRAK20.38504364
135UHMK10.37458304
136FGR0.37374159
137TAOK20.37296171
138CSNK2A10.36113677
139PTK20.35189068
140TAOK10.35081011
141MAP3K110.34202577
142MARK30.34170432
143PRKCI0.33670462
144PRKD20.33315130
145STK30.33296524
146NME20.31966819
147MAPK140.31900292
148MAP2K20.31575481
149RPS6KA20.31380798
150AKT10.30642139
151ERBB30.30580212
152CHUK0.30540323
153RIPK10.29488545

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.92895300
2Mismatch repair_Homo sapiens_hsa034304.14592886
3* Spliceosome_Homo sapiens_hsa030403.52527015
4Base excision repair_Homo sapiens_hsa034103.28963287
5* RNA transport_Homo sapiens_hsa030132.86571534
6Cell cycle_Homo sapiens_hsa041102.83056285
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.72883658
8One carbon pool by folate_Homo sapiens_hsa006702.49356718
9Nucleotide excision repair_Homo sapiens_hsa034202.47015275
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.43461185
11Homologous recombination_Homo sapiens_hsa034402.40340799
12Ribosome_Homo sapiens_hsa030102.32963195
13* mRNA surveillance pathway_Homo sapiens_hsa030152.07025580
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.05104000
15Proteasome_Homo sapiens_hsa030501.82057330
16RNA polymerase_Homo sapiens_hsa030201.78883483
17Non-homologous end-joining_Homo sapiens_hsa034501.77860243
18Pyrimidine metabolism_Homo sapiens_hsa002401.68529161
19Fanconi anemia pathway_Homo sapiens_hsa034601.65440930
20RNA degradation_Homo sapiens_hsa030181.63076808
21Other glycan degradation_Homo sapiens_hsa005111.62872819
22Renal cell carcinoma_Homo sapiens_hsa052111.41383961
23p53 signaling pathway_Homo sapiens_hsa041151.41261443
24Osteoclast differentiation_Homo sapiens_hsa043801.31205350
25Notch signaling pathway_Homo sapiens_hsa043301.29130856
26Epstein-Barr virus infection_Homo sapiens_hsa051691.28258076
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.24644871
28HTLV-I infection_Homo sapiens_hsa051661.24155169
29Chronic myeloid leukemia_Homo sapiens_hsa052201.23625316
30Viral carcinogenesis_Homo sapiens_hsa052031.19054791
31Longevity regulating pathway - mammal_Homo sapiens_hsa042111.18393516
32Antigen processing and presentation_Homo sapiens_hsa046121.18060779
33ErbB signaling pathway_Homo sapiens_hsa040121.17772061
34Choline metabolism in cancer_Homo sapiens_hsa052311.15682414
35Herpes simplex infection_Homo sapiens_hsa051681.15530378
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.14810473
37Primary immunodeficiency_Homo sapiens_hsa053401.14759712
38Colorectal cancer_Homo sapiens_hsa052101.11632958
39Basal cell carcinoma_Homo sapiens_hsa052171.10901332
40Prolactin signaling pathway_Homo sapiens_hsa049171.09442757
41Basal transcription factors_Homo sapiens_hsa030221.06728478
42Oocyte meiosis_Homo sapiens_hsa041141.06320178
43Thyroid cancer_Homo sapiens_hsa052161.06079282
44MicroRNAs in cancer_Homo sapiens_hsa052061.04492025
45Phospholipase D signaling pathway_Homo sapiens_hsa040721.01769821
46GnRH signaling pathway_Homo sapiens_hsa049120.99549532
47Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97611297
48Hepatitis C_Homo sapiens_hsa051600.95660690
49Small cell lung cancer_Homo sapiens_hsa052220.94847638
50Estrogen signaling pathway_Homo sapiens_hsa049150.92534626
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90189241
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89890778
53Inositol phosphate metabolism_Homo sapiens_hsa005620.88979392
54Fructose and mannose metabolism_Homo sapiens_hsa000510.87431399
55TNF signaling pathway_Homo sapiens_hsa046680.85307345
56Hippo signaling pathway_Homo sapiens_hsa043900.84612392
57Toll-like receptor signaling pathway_Homo sapiens_hsa046200.84312921
58Insulin resistance_Homo sapiens_hsa049310.84133546
59Acute myeloid leukemia_Homo sapiens_hsa052210.83257290
60Lysine degradation_Homo sapiens_hsa003100.82968357
61mTOR signaling pathway_Homo sapiens_hsa041500.82852688
62Non-small cell lung cancer_Homo sapiens_hsa052230.82505520
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80199456
64Biosynthesis of amino acids_Homo sapiens_hsa012300.79892327
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79394151
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.78817134
67Systemic lupus erythematosus_Homo sapiens_hsa053220.77893422
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.77016808
69Viral myocarditis_Homo sapiens_hsa054160.75728944
70Prion diseases_Homo sapiens_hsa050200.75099203
71AMPK signaling pathway_Homo sapiens_hsa041520.75046807
72Purine metabolism_Homo sapiens_hsa002300.74399195
73Platelet activation_Homo sapiens_hsa046110.73615794
74Focal adhesion_Homo sapiens_hsa045100.73514727
75Endometrial cancer_Homo sapiens_hsa052130.72853896
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72639861
77Legionellosis_Homo sapiens_hsa051340.72364592
78Cyanoamino acid metabolism_Homo sapiens_hsa004600.71892850
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71454252
80Bladder cancer_Homo sapiens_hsa052190.70998803
81Hepatitis B_Homo sapiens_hsa051610.70902584
82Apoptosis_Homo sapiens_hsa042100.69172036
83N-Glycan biosynthesis_Homo sapiens_hsa005100.67892204
84Hedgehog signaling pathway_Homo sapiens_hsa043400.67645521
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66215098
86Measles_Homo sapiens_hsa051620.65910732
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.64844351
88Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63733734
89Shigellosis_Homo sapiens_hsa051310.63495378
90RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63161195
91Selenocompound metabolism_Homo sapiens_hsa004500.62783764
92B cell receptor signaling pathway_Homo sapiens_hsa046620.62514864
93Chemokine signaling pathway_Homo sapiens_hsa040620.61631572
94Pancreatic cancer_Homo sapiens_hsa052120.61494883
952-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.61084101
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.60831976
97Amoebiasis_Homo sapiens_hsa051460.58855682
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58730530
99Type II diabetes mellitus_Homo sapiens_hsa049300.58653242
100Tuberculosis_Homo sapiens_hsa051520.58091025
101Pathways in cancer_Homo sapiens_hsa052000.57331861
102Staphylococcus aureus infection_Homo sapiens_hsa051500.55803085
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.55323463
104T cell receptor signaling pathway_Homo sapiens_hsa046600.55239603
105Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54404488
106Pentose phosphate pathway_Homo sapiens_hsa000300.54268710
107Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53988769
108TGF-beta signaling pathway_Homo sapiens_hsa043500.53941386
109Adherens junction_Homo sapiens_hsa045200.53893717
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53368782
111Proteoglycans in cancer_Homo sapiens_hsa052050.52920961
112MAPK signaling pathway_Homo sapiens_hsa040100.51988209
113HIF-1 signaling pathway_Homo sapiens_hsa040660.51514609
114Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51421900
115Melanogenesis_Homo sapiens_hsa049160.49202538
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49196020
117Long-term potentiation_Homo sapiens_hsa047200.48799709
118Prostate cancer_Homo sapiens_hsa052150.44829112
119Alcoholism_Homo sapiens_hsa050340.43591878
120Cysteine and methionine metabolism_Homo sapiens_hsa002700.43343673
121Wnt signaling pathway_Homo sapiens_hsa043100.43017534
122NF-kappa B signaling pathway_Homo sapiens_hsa040640.41881096
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39494875
124* Influenza A_Homo sapiens_hsa051640.39406353
125Leukocyte transendothelial migration_Homo sapiens_hsa046700.39000090
126Sulfur relay system_Homo sapiens_hsa041220.36076347
127AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35535684
128Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.35154934
129Carbon metabolism_Homo sapiens_hsa012000.34683711
130FoxO signaling pathway_Homo sapiens_hsa040680.33557045
131Toxoplasmosis_Homo sapiens_hsa051450.33383470
132Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32449954
133Glioma_Homo sapiens_hsa052140.32367934
134Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.29681017
135VEGF signaling pathway_Homo sapiens_hsa043700.29242778
136Leishmaniasis_Homo sapiens_hsa051400.28106345
137Insulin signaling pathway_Homo sapiens_hsa049100.27504947
138Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27162339

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