DDX3P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.88930567
2pyrimidine nucleobase catabolic process (GO:0006208)4.82839335
3neural tube formation (GO:0001841)4.70361028
4behavioral response to ethanol (GO:0048149)4.54485312
5urinary tract smooth muscle contraction (GO:0014848)4.46912020
6nonmotile primary cilium assembly (GO:0035058)4.46016113
7protein localization to cilium (GO:0061512)4.37504901
8limb bud formation (GO:0060174)4.35788115
9neuronal action potential (GO:0019228)4.02095637
10negative regulation of cytosolic calcium ion concentration (GO:0051481)3.96685878
11nucleobase catabolic process (GO:0046113)3.91631417
12positive regulation of action potential (GO:0045760)3.91579887
13response to pheromone (GO:0019236)3.82920091
14tachykinin receptor signaling pathway (GO:0007217)3.68934599
15negative regulation of synaptic transmission, GABAergic (GO:0032229)3.68351282
16regulation of cilium movement (GO:0003352)3.65587613
17protein polyglutamylation (GO:0018095)3.57386452
18olfactory bulb development (GO:0021772)3.43347721
19snRNA transcription (GO:0009301)3.34177303
20gamma-aminobutyric acid transport (GO:0015812)3.30595856
21auditory behavior (GO:0031223)3.28469984
22regulation of meiosis I (GO:0060631)3.18398366
23negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.15683511
24presynaptic membrane assembly (GO:0097105)3.14981460
25somite rostral/caudal axis specification (GO:0032525)3.12396000
26negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.11478515
27negative regulation of translation, ncRNA-mediated (GO:0040033)3.11478515
28regulation of translation, ncRNA-mediated (GO:0045974)3.11478515
29glial cell proliferation (GO:0014009)3.09692300
30G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.06341603
31intraciliary transport (GO:0042073)3.04433976
32cilium assembly (GO:0042384)3.03773050
33synaptic transmission, cholinergic (GO:0007271)3.03770118
34membrane depolarization during action potential (GO:0086010)3.02492391
35neuronal action potential propagation (GO:0019227)3.02466759
36regulation of action potential (GO:0098900)3.02174666
37cilium organization (GO:0044782)3.02159867
38mechanosensory behavior (GO:0007638)3.00870644
39response to auditory stimulus (GO:0010996)2.98851586
40regulation of glutamate secretion (GO:0014048)2.97216393
41cell migration in hindbrain (GO:0021535)2.95447789
42positive regulation of synaptic transmission, GABAergic (GO:0032230)2.93122330
43cornea development in camera-type eye (GO:0061303)2.92694363
44detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.91676342
45regulation of synaptic transmission, GABAergic (GO:0032228)2.91134852
46DNA double-strand break processing (GO:0000729)2.90121428
47establishment of protein localization to Golgi (GO:0072600)2.89481742
48spinal cord development (GO:0021510)2.89391236
49sympathetic nervous system development (GO:0048485)2.88027578
50regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.87703320
51righting reflex (GO:0060013)2.86269803
52presynaptic membrane organization (GO:0097090)2.86106945
53pyrimidine dimer repair (GO:0006290)2.82617316
54retinal ganglion cell axon guidance (GO:0031290)2.82095045
55melanosome transport (GO:0032402)2.77184955
56microtubule depolymerization (GO:0007019)2.77142041
57embryonic retina morphogenesis in camera-type eye (GO:0060059)2.75731873
58establishment of melanosome localization (GO:0032401)2.75188847
59cilium or flagellum-dependent cell motility (GO:0001539)2.75110992
60proline transport (GO:0015824)2.73222111
61pigment granule transport (GO:0051904)2.73130099
62cilium morphogenesis (GO:0060271)2.72353687
63reflex (GO:0060004)2.72135465
64establishment of pigment granule localization (GO:0051905)2.71397077
65regulation of microtubule-based movement (GO:0060632)2.71129254
66photoreceptor cell maintenance (GO:0045494)2.70060052
67somite development (GO:0061053)2.69134220
68detection of light stimulus involved in sensory perception (GO:0050962)2.67745364
69detection of light stimulus involved in visual perception (GO:0050908)2.67745364
70positive regulation of mitochondrial fission (GO:0090141)2.65733877
71central nervous system neuron axonogenesis (GO:0021955)2.65103985
72DNA integration (GO:0015074)2.65059811
73regulation of collateral sprouting (GO:0048670)2.64873787
74central nervous system projection neuron axonogenesis (GO:0021952)2.62994396
75epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.61443053
76action potential (GO:0001508)2.61287673
77melanosome localization (GO:0032400)2.60548761
78brain morphogenesis (GO:0048854)2.59789746
79vascular smooth muscle contraction (GO:0014829)2.58948939
80epithelial cilium movement (GO:0003351)2.58769535
81pigment granule localization (GO:0051875)2.57645936
82calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.55344899
83negative regulation of amino acid transport (GO:0051956)2.54658051
84positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.54591263
85microtubule anchoring (GO:0034453)2.53700354
86calcium ion import (GO:0070509)2.51513907
87head development (GO:0060322)2.51332161
88appendage development (GO:0048736)2.50856384
89limb development (GO:0060173)2.50856384
90phosphorelay signal transduction system (GO:0000160)2.49244466
91transmission of nerve impulse (GO:0019226)2.49060269
92artery smooth muscle contraction (GO:0014824)2.48350438
93postsynaptic membrane organization (GO:0001941)2.48150761
94positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.47762892
95mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.47762892
96glycosphingolipid biosynthetic process (GO:0006688)2.47697851
97behavioral fear response (GO:0001662)2.47087680
98behavioral defense response (GO:0002209)2.47087680
99protein targeting to Golgi (GO:0000042)2.45508286
100chemosensory behavior (GO:0007635)2.45448664

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.60285130
2EZH2_22144423_ChIP-Seq_EOC_Human3.53784286
3GBX2_23144817_ChIP-Seq_PC3_Human3.26805813
4IGF1R_20145208_ChIP-Seq_DFB_Human3.10565144
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.88176027
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.87113468
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.82548231
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.55516412
9TAF15_26573619_Chip-Seq_HEK293_Human2.52903515
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.45468426
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.42908637
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.25754463
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.22287198
14P300_19829295_ChIP-Seq_ESCs_Human2.18999354
15AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.05941620
16SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.04824609
17EWS_26573619_Chip-Seq_HEK293_Human2.04783433
18FUS_26573619_Chip-Seq_HEK293_Human2.03735288
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.96301439
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94807965
21SMAD4_21799915_ChIP-Seq_A2780_Human1.94207019
22PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.93064530
23PIAS1_25552417_ChIP-Seq_VCAP_Human1.92476445
24VDR_22108803_ChIP-Seq_LS180_Human1.91157064
25SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.82543719
26CBX2_27304074_Chip-Seq_ESCs_Mouse1.81634663
27STAT3_23295773_ChIP-Seq_U87_Human1.72715493
28UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.70037386
29OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.67987927
30ER_23166858_ChIP-Seq_MCF-7_Human1.66701594
31IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.66303671
32CBP_20019798_ChIP-Seq_JUKART_Human1.66303671
33MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.66257902
34TOP2B_26459242_ChIP-Seq_MCF-7_Human1.61437226
35RNF2_27304074_Chip-Seq_NSC_Mouse1.60224721
36SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.58252521
37TCF4_23295773_ChIP-Seq_U87_Human1.55598239
38AR_25329375_ChIP-Seq_VCAP_Human1.54842220
39SMAD3_21741376_ChIP-Seq_EPCs_Human1.52169805
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.50550361
41POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.48412957
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48412957
43NR3C1_21868756_ChIP-Seq_MCF10A_Human1.47321901
44BCAT_22108803_ChIP-Seq_LS180_Human1.43471506
45MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38147003
46TCF4_22108803_ChIP-Seq_LS180_Human1.35968978
47REST_21632747_ChIP-Seq_MESCs_Mouse1.35821441
48KLF5_20875108_ChIP-Seq_MESCs_Mouse1.35076286
49IRF1_19129219_ChIP-ChIP_H3396_Human1.33118442
50CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31354687
51NANOG_18555785_Chip-Seq_ESCs_Mouse1.30940516
52SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.30829239
53NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.30069756
54RUNX2_22187159_ChIP-Seq_PCA_Human1.29240157
55TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29197936
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26320147
57SOX2_21211035_ChIP-Seq_LN229_Gbm1.25367832
58TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24019456
59BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.23558500
60TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21642852
61EZH2_27304074_Chip-Seq_ESCs_Mouse1.21421456
62HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20338002
63TAL1_26923725_Chip-Seq_HPCs_Mouse1.19795305
64FLI1_21867929_ChIP-Seq_TH2_Mouse1.19332868
65SOX9_26525672_Chip-Seq_HEART_Mouse1.18713135
66EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18596493
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17187228
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.15498134
69KDM2B_26808549_Chip-Seq_REH_Human1.15451922
70MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14539903
71SOX2_19829295_ChIP-Seq_ESCs_Human1.14517195
72NANOG_19829295_ChIP-Seq_ESCs_Human1.14517195
73EED_16625203_ChIP-ChIP_MESCs_Mouse1.14038900
74NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13973441
75NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13973441
76KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13266680
77CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.13008065
78P53_22387025_ChIP-Seq_ESCs_Mouse1.12179701
79JARID2_20064375_ChIP-Seq_MESCs_Mouse1.12095687
80TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11964837
81MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10989665
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.10401767
83BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10151490
84AR_21572438_ChIP-Seq_LNCaP_Human1.09428069
85AHR_22903824_ChIP-Seq_MCF-7_Human1.09015566
86PRDM14_20953172_ChIP-Seq_ESCs_Human1.08224851
87EZH2_27294783_Chip-Seq_NPCs_Mouse1.07807839
88E2F1_18555785_Chip-Seq_ESCs_Mouse1.07636011
89TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.07459167
90SMAD4_21741376_ChIP-Seq_EPCs_Human1.07366392
91CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97998880
92TP53_22573176_ChIP-Seq_HFKS_Human0.96767975
93RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96646971
94PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96496801
95SUZ12_18555785_Chip-Seq_ESCs_Mouse0.94633836
96AR_19668381_ChIP-Seq_PC3_Human0.94401513
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94106812
98CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.93884449
99NFE2_27457419_Chip-Seq_LIVER_Mouse0.93852814
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93640219

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001529_abnormal_vocalization4.64884917
2MP0003880_abnormal_central_pattern3.68191245
3MP0001968_abnormal_touch/_nociception3.07800029
4MP0008789_abnormal_olfactory_epithelium2.88359270
5MP0001984_abnormal_olfaction2.73011216
6MP0005394_taste/olfaction_phenotype2.46734361
7MP0005499_abnormal_olfactory_system2.46734361
8MP0009046_muscle_twitch2.27769537
9MP0002736_abnormal_nociception_after2.25561695
10MP0002735_abnormal_chemical_nociception2.24024572
11MP0006276_abnormal_autonomic_nervous2.08452335
12MP0005551_abnormal_eye_electrophysiolog2.04783823
13MP0004270_analgesia1.97856955
14MP0004145_abnormal_muscle_electrophysio1.95233617
15MP0005253_abnormal_eye_physiology1.92848295
16MP0005423_abnormal_somatic_nervous1.87501062
17MP0005645_abnormal_hypothalamus_physiol1.85555290
18MP0000569_abnormal_digit_pigmentation1.82251078
19MP0001188_hyperpigmentation1.81403306
20MP0002102_abnormal_ear_morphology1.80925023
21MP0009745_abnormal_behavioral_response1.80349180
22MP0000778_abnormal_nervous_system1.76961240
23MP0004924_abnormal_behavior1.75736980
24MP0005386_behavior/neurological_phenoty1.75736980
25MP0001486_abnormal_startle_reflex1.74862168
26MP0003011_delayed_dark_adaptation1.72925505
27MP0002734_abnormal_mechanical_nocicepti1.72380439
28MP0006292_abnormal_olfactory_placode1.71427719
29MP0002090_abnormal_vision1.65625276
30MP0008057_abnormal_DNA_replication1.64292402
31MP0000631_abnormal_neuroendocrine_gland1.64264407
32MP0002272_abnormal_nervous_system1.64099674
33MP0002751_abnormal_autonomic_nervous1.64092209
34MP0001986_abnormal_taste_sensitivity1.62199670
35MP0001485_abnormal_pinna_reflex1.62012072
36MP0004859_abnormal_synaptic_plasticity1.61474465
37MP0006072_abnormal_retinal_apoptosis1.57212225
38MP0002184_abnormal_innervation1.56665894
39MP0002572_abnormal_emotion/affect_behav1.55017390
40MP0003635_abnormal_synaptic_transmissio1.48379454
41MP0001970_abnormal_pain_threshold1.47569889
42MP0002067_abnormal_sensory_capabilities1.47441396
43MP0002557_abnormal_social/conspecific_i1.40682475
44MP0003122_maternal_imprinting1.35566882
45MP0000647_abnormal_sebaceous_gland1.34998013
46MP0002064_seizures1.33243429
47MP0002063_abnormal_learning/memory/cond1.31041005
48MP0003890_abnormal_embryonic-extraembry1.27279098
49MP0004043_abnormal_pH_regulation1.27235938
50MP0002653_abnormal_ependyma_morphology1.27229204
51MP0004133_heterotaxia1.26981757
52MP0009697_abnormal_copulation1.25451618
53MP0004885_abnormal_endolymph1.24948400
54MP0005646_abnormal_pituitary_gland1.24825596
55MP0004142_abnormal_muscle_tone1.24138052
56MP0002938_white_spotting1.20786519
57MP0002234_abnormal_pharynx_morphology1.19862439
58MP0003937_abnormal_limbs/digits/tail_de1.16476596
59MP0002733_abnormal_thermal_nociception1.14540774
60MP0002752_abnormal_somatic_nervous1.13972723
61MP0004147_increased_porphyrin_level1.12737270
62MP0010386_abnormal_urinary_bladder1.10994824
63MP0002882_abnormal_neuron_morphology1.10792340
64MP0003787_abnormal_imprinting1.08458277
65MP0003195_calcinosis1.08177727
66MP0002233_abnormal_nose_morphology1.06050302
67MP0004215_abnormal_myocardial_fiber1.05551813
68MP0005187_abnormal_penis_morphology1.04941252
69MP0004742_abnormal_vestibular_system1.04165875
70MP0002822_catalepsy1.00660895
71MP0008872_abnormal_physiological_respon1.00553121
72MP0005195_abnormal_posterior_eye0.99577629
73MP0003119_abnormal_digestive_system0.98674719
74MP0000751_myopathy0.98025106
75MP0005084_abnormal_gallbladder_morpholo0.97717507
76MP0000427_abnormal_hair_cycle0.97567259
77MP0000955_abnormal_spinal_cord0.97338666
78MP0005248_abnormal_Harderian_gland0.95246942
79MP0003385_abnormal_body_wall0.95200873
80MP0001764_abnormal_homeostasis0.94531279
81MP0000383_abnormal_hair_follicle0.92308919
82MP0005391_vision/eye_phenotype0.91538172
83MP0001501_abnormal_sleep_pattern0.89505364
84MP0003283_abnormal_digestive_organ0.87670835
85MP0004811_abnormal_neuron_physiology0.87210138
86MP0008058_abnormal_DNA_repair0.86957584
87MP0003633_abnormal_nervous_system0.86391722
88MP0002152_abnormal_brain_morphology0.85987282
89MP0001963_abnormal_hearing_physiology0.84978003
90MP0002909_abnormal_adrenal_gland0.83526179
91MP0003121_genomic_imprinting0.83151240
92MP0008877_abnormal_DNA_methylation0.82806563
93MP0000026_abnormal_inner_ear0.82355651
94MP0003861_abnormal_nervous_system0.79796286
95MP0002127_abnormal_cardiovascular_syste0.76193976
96MP0003646_muscle_fatigue0.74925945
97MP0004085_abnormal_heartbeat0.72223840
98MP0003698_abnormal_male_reproductive0.71697113
99MP0002066_abnormal_motor_capabilities/c0.71400778
100MP0000049_abnormal_middle_ear0.71159305

Predicted human phenotypes

RankGene SetZ-score
1Medial flaring of the eyebrow (HP:0010747)4.11877101
2Gait imbalance (HP:0002141)3.97664999
3Congenital primary aphakia (HP:0007707)3.74491703
4Pancreatic fibrosis (HP:0100732)3.71706437
5Hyperventilation (HP:0002883)3.68685601
6Pancreatic cysts (HP:0001737)3.59496980
7True hermaphroditism (HP:0010459)3.51368784
8Nephronophthisis (HP:0000090)3.41364354
9Nephrogenic diabetes insipidus (HP:0009806)3.37580243
10Abolished electroretinogram (ERG) (HP:0000550)3.36879142
11Congenital stationary night blindness (HP:0007642)3.28662735
12Vitreoretinal degeneration (HP:0000655)3.24932269
13Genital tract atresia (HP:0001827)3.20573392
14Vaginal atresia (HP:0000148)3.19869161
15Cerebellar dysplasia (HP:0007033)3.18548001
16Molar tooth sign on MRI (HP:0002419)3.08318350
17Abnormality of midbrain morphology (HP:0002418)3.08318350
18Type II lissencephaly (HP:0007260)2.95185931
19Postaxial foot polydactyly (HP:0001830)2.94356986
20Gaze-evoked nystagmus (HP:0000640)2.91064369
21Poor coordination (HP:0002370)2.86517164
22Abnormality of the renal medulla (HP:0100957)2.79206379
23Chronic hepatic failure (HP:0100626)2.78301513
24Optic nerve hypoplasia (HP:0000609)2.78013045
25Adactyly (HP:0009776)2.73308660
26Postaxial hand polydactyly (HP:0001162)2.64476038
27Cystic liver disease (HP:0006706)2.56446783
28Febrile seizures (HP:0002373)2.56063272
29Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.55199982
30Abnormality of alanine metabolism (HP:0010916)2.55199982
31Hyperalaninemia (HP:0003348)2.55199982
32Focal seizures (HP:0007359)2.54512028
33Polyphagia (HP:0002591)2.49302129
34Pendular nystagmus (HP:0012043)2.48843393
35Congenital hepatic fibrosis (HP:0002612)2.47527818
36Increased corneal curvature (HP:0100692)2.44105057
37Keratoconus (HP:0000563)2.44105057
38Progressive cerebellar ataxia (HP:0002073)2.42531757
39Drooling (HP:0002307)2.40725273
40Lissencephaly (HP:0001339)2.37188102
41Chorioretinal atrophy (HP:0000533)2.34210716
42Anencephaly (HP:0002323)2.32886356
43Bony spicule pigmentary retinopathy (HP:0007737)2.32245367
44Aplasia/Hypoplasia of the tongue (HP:0010295)2.30183462
45Intestinal atresia (HP:0011100)2.27856876
46Attenuation of retinal blood vessels (HP:0007843)2.27764045
47Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.26383142
48Atonic seizures (HP:0010819)2.23557278
49Absent speech (HP:0001344)2.22897897
50Abnormality of the renal cortex (HP:0011035)2.16321442
513-Methylglutaconic aciduria (HP:0003535)2.15583052
52Excessive salivation (HP:0003781)2.13726513
53Colon cancer (HP:0003003)2.10465916
54Narrow forehead (HP:0000341)2.09821784
55Thyroid-stimulating hormone excess (HP:0002925)2.09720438
56Hypoplastic iliac wings (HP:0002866)2.09071293
57Aplasia/Hypoplasia of the tibia (HP:0005772)2.08264681
58Retinal dysplasia (HP:0007973)2.05616087
59Broad foot (HP:0001769)2.04979577
60Hemiparesis (HP:0001269)2.03830299
61Growth hormone deficiency (HP:0000824)2.02031256
62Aplasia/Hypoplasia of the lens (HP:0008063)2.00565320
63Tubulointerstitial nephritis (HP:0001970)1.97057407
64Focal motor seizures (HP:0011153)1.95905456
65Astigmatism (HP:0000483)1.95769245
66Pachygyria (HP:0001302)1.95048165
67Broad-based gait (HP:0002136)1.94296573
68Specific learning disability (HP:0001328)1.92663211
69Renal cortical cysts (HP:0000803)1.89167757
70Severe muscular hypotonia (HP:0006829)1.88982759
71Dialeptic seizures (HP:0011146)1.83517618
72Patellar aplasia (HP:0006443)1.82262528
73Oligodactyly (hands) (HP:0001180)1.81735181
74Sclerocornea (HP:0000647)1.80178244
75Protruding tongue (HP:0010808)1.79892353
76Prominent nasal bridge (HP:0000426)1.79500535
77Severe Myopia (HP:0011003)1.79382617
78Dandy-Walker malformation (HP:0001305)1.79285132
79Disproportionate short-trunk short stature (HP:0003521)1.78291634
80Hypoplasia of the pons (HP:0012110)1.77849358
81Retinitis pigmentosa (HP:0000510)1.77350645
82Short foot (HP:0001773)1.76237214
83Left ventricular hypertrophy (HP:0001712)1.75590736
84Hypothermia (HP:0002045)1.74742165
85Preaxial hand polydactyly (HP:0001177)1.73289519
86Aplasia/Hypoplasia of the fovea (HP:0008060)1.72458117
87Hypoplasia of the fovea (HP:0007750)1.72458117
88Epileptic encephalopathy (HP:0200134)1.71185710
89Short 1st metacarpal (HP:0010034)1.71063350
90Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.71063350
91Hepatoblastoma (HP:0002884)1.70592409
92Aplasia/Hypoplasia of the patella (HP:0006498)1.69092346
93Dysdiadochokinesis (HP:0002075)1.68511331
94Slow-growing hair (HP:0002217)1.68499190
95Abnormality of hair growth rate (HP:0011363)1.68499190
96Abnormality of the astrocytes (HP:0100707)1.65626481
97Astrocytoma (HP:0009592)1.65626481
98Abnormal rod and cone electroretinograms (HP:0008323)1.65089526
99Acute necrotizing encephalopathy (HP:0006965)1.65033754
100Abnormality of the intervertebral disk (HP:0005108)1.64428036

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.42113169
2MAP3K43.30051392
3NUAK13.26415177
4FRK3.15110316
5AKT33.11511968
6MARK12.93729583
7LATS12.92644407
8WNK32.66887627
9MAPK132.66079893
10MAP2K72.38426720
11MAP4K22.33750638
12TRIM282.32531278
13ADRBK22.27897999
14BCR2.27377138
15TNIK2.03897119
16DYRK31.91501688
17INSRR1.84814078
18DAPK21.82432256
19PAK31.74067739
20ERBB31.68800677
21GRK11.51484748
22EPHA41.49326945
23CSNK1A1L1.45025193
24PNCK1.44283818
25DYRK21.37426059
26CAMKK21.31363125
27CSNK1G21.27644062
28NTRK21.24891614
29CAMK1G1.22619690
30CSNK1G31.16709637
31BMPR1B1.16308828
32PRKCE1.12640262
33CSNK1G11.12520923
34NTRK31.07866101
35IRAK11.06821024
36PLK21.05339771
37BRD41.00962072
38PRKCG0.97047912
39SGK20.94867768
40OXSR10.94027470
41MAP2K40.93873526
42CAMK40.88506350
43NLK0.86834784
44PRKD30.85278030
45DYRK1A0.84919670
46IRAK20.84258181
47PDK20.82509447
48PIK3CA0.81684106
49MINK10.80846640
50PKN10.76317415
51STK390.75852858
52SIK30.75519152
53SGK4940.75226528
54SGK2230.75226528
55WNK40.74579773
56CAMK1D0.73560739
57CAMK2A0.71797291
58STK38L0.71072707
59MUSK0.68791588
60RPS6KA40.68103978
61MAP3K60.67324825
62BRAF0.67157385
63PINK10.64660416
64MKNK20.63320888
65VRK10.63262337
66FER0.62296857
67CAMK10.59935455
68ADRBK10.59881952
69STK30.58775565
70MET0.57420035
71OBSCN0.56748449
72PTK2B0.55265522
73UHMK10.53427588
74CDC70.53172650
75TAF10.52810977
76TIE10.52035827
77ZAK0.50951826
78MAP3K70.49727354
79STK110.49175921
80KSR10.46278185
81PRKG10.45228464
82BRSK20.44505726
83CAMK2B0.43130965
84YES10.42189097
85NEK10.41507344
86ERBB20.40738988
87PHKG10.40611008
88PHKG20.40611008
89PRKAA10.40587258
90PAK60.39272660
91PRKAA20.38913995
92CHUK0.35241247
93SIK20.35169498
94CSNK1D0.35040346
95CDK50.34976417
96PLK40.34769282
97PRKACA0.32055335
98SRPK10.32005120
99SGK30.31717158
100WNK10.31049768

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.37521287
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.79937930
3Nitrogen metabolism_Homo sapiens_hsa009102.55886842
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.43716840
5Taste transduction_Homo sapiens_hsa047422.33438207
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.24391887
7Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.19906989
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.17139912
9GABAergic synapse_Homo sapiens_hsa047272.13281586
10Phototransduction_Homo sapiens_hsa047442.03668472
11Butanoate metabolism_Homo sapiens_hsa006502.00886525
12Morphine addiction_Homo sapiens_hsa050322.00257107
13Protein export_Homo sapiens_hsa030601.93407144
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.92369390
15Circadian entrainment_Homo sapiens_hsa047131.82891027
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.81848230
17Propanoate metabolism_Homo sapiens_hsa006401.77450841
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.76681037
19Glutamatergic synapse_Homo sapiens_hsa047241.68949886
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.57306400
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.54216835
22Ether lipid metabolism_Homo sapiens_hsa005651.53168772
23Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.52308712
24Regulation of autophagy_Homo sapiens_hsa041401.51468593
25Fatty acid elongation_Homo sapiens_hsa000621.49637538
26Insulin secretion_Homo sapiens_hsa049111.45477002
27Steroid biosynthesis_Homo sapiens_hsa001001.33436174
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32424851
29Serotonergic synapse_Homo sapiens_hsa047261.31848291
30Dopaminergic synapse_Homo sapiens_hsa047281.29026322
31Linoleic acid metabolism_Homo sapiens_hsa005911.23729946
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.22103828
33Long-term depression_Homo sapiens_hsa047301.21074074
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.19793103
35Chemical carcinogenesis_Homo sapiens_hsa052041.17877090
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.16676399
37Oxidative phosphorylation_Homo sapiens_hsa001901.15721732
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15643030
39Basal transcription factors_Homo sapiens_hsa030221.13073940
40Calcium signaling pathway_Homo sapiens_hsa040201.12472009
41Fanconi anemia pathway_Homo sapiens_hsa034601.11917776
42Axon guidance_Homo sapiens_hsa043601.10700392
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.08408769
44Cholinergic synapse_Homo sapiens_hsa047251.04879760
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03520971
46Amphetamine addiction_Homo sapiens_hsa050311.02669691
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99016826
48Retinol metabolism_Homo sapiens_hsa008300.94859486
49Salivary secretion_Homo sapiens_hsa049700.90103840
50Circadian rhythm_Homo sapiens_hsa047100.89983847
51Cocaine addiction_Homo sapiens_hsa050300.86617684
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86248130
53Lysine degradation_Homo sapiens_hsa003100.85651849
54Collecting duct acid secretion_Homo sapiens_hsa049660.85315414
55Non-homologous end-joining_Homo sapiens_hsa034500.84145440
56Olfactory transduction_Homo sapiens_hsa047400.82422892
57Cardiac muscle contraction_Homo sapiens_hsa042600.82112742
58Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78913104
59Parkinsons disease_Homo sapiens_hsa050120.78671948
60RNA degradation_Homo sapiens_hsa030180.76180220
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76164282
62Peroxisome_Homo sapiens_hsa041460.75694094
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73102251
64Renin secretion_Homo sapiens_hsa049240.70534488
65Folate biosynthesis_Homo sapiens_hsa007900.69628546
66Hedgehog signaling pathway_Homo sapiens_hsa043400.69591500
67Alzheimers disease_Homo sapiens_hsa050100.68138391
68Huntingtons disease_Homo sapiens_hsa050160.67659154
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.58998381
70Synaptic vesicle cycle_Homo sapiens_hsa047210.58896463
71Long-term potentiation_Homo sapiens_hsa047200.58852083
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57987337
73Oxytocin signaling pathway_Homo sapiens_hsa049210.57975719
74ABC transporters_Homo sapiens_hsa020100.57603869
75Caffeine metabolism_Homo sapiens_hsa002320.56016854
76cAMP signaling pathway_Homo sapiens_hsa040240.55409148
77beta-Alanine metabolism_Homo sapiens_hsa004100.53743859
78Fat digestion and absorption_Homo sapiens_hsa049750.53734109
79Hippo signaling pathway_Homo sapiens_hsa043900.50442077
80Ras signaling pathway_Homo sapiens_hsa040140.50158198
81Tryptophan metabolism_Homo sapiens_hsa003800.48931487
82Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48266138
83Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.47723345
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46242403
85Type II diabetes mellitus_Homo sapiens_hsa049300.45244977
86Basal cell carcinoma_Homo sapiens_hsa052170.44847424
87Gap junction_Homo sapiens_hsa045400.42479203
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.40333954
89Ovarian steroidogenesis_Homo sapiens_hsa049130.39629648
90Dorso-ventral axis formation_Homo sapiens_hsa043200.37959282
91Glucagon signaling pathway_Homo sapiens_hsa049220.37270748
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34593845
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34027397
94Glycerolipid metabolism_Homo sapiens_hsa005610.34024423
95Tight junction_Homo sapiens_hsa045300.33228899
96Wnt signaling pathway_Homo sapiens_hsa043100.30891923
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30532449
98Oocyte meiosis_Homo sapiens_hsa041140.30473640
99Metabolic pathways_Homo sapiens_hsa011000.30400395
100Arachidonic acid metabolism_Homo sapiens_hsa005900.30379356

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