DDX3X

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the large DEAD-box protein family, that is defined by the presence of the conserved Asp-Glu-Ala-Asp (DEAD) motif, and has ATP-dependent RNA helicase activity. This protein has been reported to display a high level of RNA-independent ATPase activity, and unlike most DEAD-box helicases, the ATPase activity is thought to be stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. This gene has a paralog located in the nonrecombining region of the Y chromosome. Pseudogenes sharing similarity to both this gene and the DDX3Y paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.69960026
2nuclear pore organization (GO:0006999)5.49134177
3mitotic sister chromatid cohesion (GO:0007064)5.24680429
4regulation of RNA export from nucleus (GO:0046831)5.17773825
5pre-miRNA processing (GO:0031054)4.52983404
6regulation of nucleobase-containing compound transport (GO:0032239)4.28465329
7pore complex assembly (GO:0046931)4.16624012
8negative regulation of histone methylation (GO:0031061)3.97415954
9regulation of sister chromatid cohesion (GO:0007063)3.86098405
10regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.80635892
11protein localization to kinetochore (GO:0034501)3.79968155
12DNA unwinding involved in DNA replication (GO:0006268)3.75158626
13histone H2A monoubiquitination (GO:0035518)3.71356452
14cytoplasmic mRNA processing body assembly (GO:0033962)3.69168218
15definitive hemopoiesis (GO:0060216)3.68279339
16mRNA stabilization (GO:0048255)3.57561074
17RNA stabilization (GO:0043489)3.57561074
18glucocorticoid receptor signaling pathway (GO:0042921)3.55878208
19mitotic chromosome condensation (GO:0007076)3.48498911
20hippo signaling (GO:0035329)3.46228751
21mitotic nuclear envelope disassembly (GO:0007077)3.39505688
22positive regulation of gamma-delta T cell activation (GO:0046645)3.37000709
23regulation of histone H3-K9 methylation (GO:0051570)3.36399889
24nuclear envelope disassembly (GO:0051081)3.34053078
25membrane disassembly (GO:0030397)3.34053078
26NLS-bearing protein import into nucleus (GO:0006607)3.32446422
27regulation of spindle organization (GO:0090224)3.28219267
28dosage compensation (GO:0007549)3.27430837
29alternative mRNA splicing, via spliceosome (GO:0000380)3.26466416
30chromatin assembly (GO:0031497)3.23558409
31positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.20833049
32positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.20833049
33positive regulation of mitotic sister chromatid separation (GO:1901970)3.20833049
34corticosteroid receptor signaling pathway (GO:0031958)3.19446044
35positive regulation of SMAD protein import into nucleus (GO:0060391)3.19275446
36regulation of mitotic spindle organization (GO:0060236)3.18985234
37positive regulation of chromosome segregation (GO:0051984)3.13806668
38paraxial mesoderm development (GO:0048339)3.13565607
39sister chromatid segregation (GO:0000819)3.13497457
40heterochromatin organization (GO:0070828)3.11868471
41histone H3-K36 demethylation (GO:0070544)3.08057157
42monoubiquitinated protein deubiquitination (GO:0035520)3.07042115
43regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.06741129
44necroptotic process (GO:0070266)3.05552803
45* DNA duplex unwinding (GO:0032508)3.00105771
46regulation of mRNA stability (GO:0043488)2.99423123
47protein localization to chromosome, centromeric region (GO:0071459)2.97959008
48germinal center formation (GO:0002467)2.97750886
49* DNA geometric change (GO:0032392)2.97341961
50negative regulation of DNA repair (GO:0045738)2.97250047
51peptidyl-lysine dimethylation (GO:0018027)2.96620130
52regulation of histone H3-K27 methylation (GO:0061085)2.94042654
53folic acid-containing compound biosynthetic process (GO:0009396)2.91451759
54regulation of posttranscriptional gene silencing (GO:0060147)2.91236262
55regulation of gene silencing by miRNA (GO:0060964)2.91236262
56regulation of gene silencing by RNA (GO:0060966)2.91236262
57regulation of SMAD protein import into nucleus (GO:0060390)2.88431080
58regulation of DNA endoreduplication (GO:0032875)2.88327721
59negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.85059120
60nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.84224675
61phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.83962419
62regulation of translational termination (GO:0006449)2.81975622
63response to muramyl dipeptide (GO:0032495)2.81547927
64hepatocyte apoptotic process (GO:0097284)2.80724650
65regulation of B cell receptor signaling pathway (GO:0050855)2.80189600
66regulation of RNA stability (GO:0043487)2.76812481
67dorsal/ventral axis specification (GO:0009950)2.75922760
68nuclear envelope organization (GO:0006998)2.73866209
69negative regulation of histone modification (GO:0031057)2.72347301
70mitotic metaphase plate congression (GO:0007080)2.71459104
71necrotic cell death (GO:0070265)2.70134856
72embryonic process involved in female pregnancy (GO:0060136)2.69848447
73regulation of centriole replication (GO:0046599)2.69047695
74positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.68878260
75metaphase plate congression (GO:0051310)2.68120648
76* ribosome assembly (GO:0042255)2.67423880
77gastrulation with mouth forming second (GO:0001702)2.67409701
78regulation of hippo signaling (GO:0035330)2.67272369
79trophectodermal cell differentiation (GO:0001829)2.64360880
80negative regulation of RNA splicing (GO:0033119)2.64178793
81histone lysine demethylation (GO:0070076)2.62720887
82regulation of translational fidelity (GO:0006450)2.62703935
83ectodermal placode formation (GO:0060788)2.61691091
84DNA topological change (GO:0006265)2.60996529
85regulation of transforming growth factor beta2 production (GO:0032909)2.60572063
86negative regulation of mRNA processing (GO:0050686)2.60429340
87protein localization to chromosome (GO:0034502)2.59562832
88polarized epithelial cell differentiation (GO:0030859)2.59483057
89spliceosomal tri-snRNP complex assembly (GO:0000244)2.58841550
90negative regulation of fibroblast apoptotic process (GO:2000270)2.58424691
91microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.57904198
92regulation of gamma-delta T cell activation (GO:0046643)2.57576020
93embryonic foregut morphogenesis (GO:0048617)2.57561538
94histone mRNA catabolic process (GO:0071044)2.57219190
95response to peptidoglycan (GO:0032494)2.56828167
96negative regulation of chromatin modification (GO:1903309)2.55101336
97negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.53652770
98negative regulation of cell killing (GO:0031342)2.53652770
99regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.53627114
100negative regulation of mRNA metabolic process (GO:1903312)2.52372481
101regulation of DNA damage checkpoint (GO:2000001)2.52075492
102negative regulation of erythrocyte differentiation (GO:0045647)2.51758090
103histone H3-K9 demethylation (GO:0033169)2.51629242
104regulation of gamma-delta T cell differentiation (GO:0045586)2.51256615
105programmed necrotic cell death (GO:0097300)2.50756938
106regulation of fibroblast apoptotic process (GO:2000269)2.50509601
107DNA replication-dependent nucleosome assembly (GO:0006335)2.49574318
108DNA replication-dependent nucleosome organization (GO:0034723)2.49574318
109spindle assembly involved in mitosis (GO:0090307)2.49057620
110chromatin assembly or disassembly (GO:0006333)2.48360860
111anterior/posterior axis specification, embryo (GO:0008595)2.47981261
112histone demethylation (GO:0016577)2.47575620
113positive regulation of interferon-alpha production (GO:0032727)2.47564903
114cell migration involved in sprouting angiogenesis (GO:0002042)2.47101688
115positive regulation of protein import into nucleus, translocation (GO:0033160)2.46817661
116antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.45805962
117mRNA splice site selection (GO:0006376)2.44914095
118negative thymic T cell selection (GO:0045060)2.44896307
1193-UTR-mediated mRNA stabilization (GO:0070935)2.42635641
120positive regulation of RNA splicing (GO:0033120)2.42283701
121histone H2B ubiquitination (GO:0033523)2.41885258
122mitotic sister chromatid segregation (GO:0000070)2.41640499
123sister chromatid cohesion (GO:0007062)2.40643399
124non-recombinational repair (GO:0000726)2.39078728
125double-strand break repair via nonhomologous end joining (GO:0006303)2.39078728
126negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.38921318
127regulation of centrosome cycle (GO:0046605)2.38470338
128negative T cell selection (GO:0043383)2.38274237
129mRNA transport (GO:0051028)2.37579496
130gene silencing by RNA (GO:0031047)2.37255745
131regulation of translation, ncRNA-mediated (GO:0045974)2.36410722
132cellular extravasation (GO:0045123)2.36251174
133histone H3-K4 trimethylation (GO:0080182)2.32938790
134response to interleukin-15 (GO:0070672)2.32591399
135detection of molecule of bacterial origin (GO:0032490)2.32429692
136nucleus organization (GO:0006997)2.31060312
137B cell homeostasis (GO:0001782)2.31055597
138establishment of chromosome localization (GO:0051303)2.29126959
139positive regulation of cell size (GO:0045793)2.28871406
140peptidyl-lysine trimethylation (GO:0018023)2.28687721
141nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.28593026
142regulation of interferon-alpha production (GO:0032647)2.26491456
143positive regulation of mRNA catabolic process (GO:0061014)2.26176768
144detection of other organism (GO:0098543)2.25775456
145B cell proliferation (GO:0042100)2.22590408
146positive regulation of alpha-beta T cell proliferation (GO:0046641)2.14998383
147negative regulation of B cell proliferation (GO:0030889)2.14636649
148regulation of mRNA catabolic process (GO:0061013)2.14167296

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.45791693
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.26436186
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.86191407
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.11551427
5* SALL1_21062744_ChIP-ChIP_HESCs_Human3.36868568
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.30134189
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.17424254
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.84990465
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.80289930
10AR_21909140_ChIP-Seq_LNCAP_Human2.74974210
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.51053894
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.48218733
13* CLOCK_20551151_ChIP-Seq_293T_Human2.48170450
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.41600644
15MYC_22102868_ChIP-Seq_BL_Human2.39706894
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.35249381
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.35153881
18GATA1_22025678_ChIP-Seq_K562_Human2.29218506
19* SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.15303898
20IRF8_22096565_ChIP-ChIP_GC-B_Human2.13473561
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.10190130
22BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.08139657
23* TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.05782683
24E2F1_21310950_ChIP-Seq_MCF-7_Human2.04872417
25MYB_26560356_Chip-Seq_TH2_Human2.02689204
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.01933747
27TP63_19390658_ChIP-ChIP_HaCaT_Human1.99807608
28MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.99591371
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.98545137
30* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.98172420
31ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.92760819
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.90969824
33MYB_26560356_Chip-Seq_TH1_Human1.80223029
34IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.78544536
35MYC_18555785_ChIP-Seq_MESCs_Mouse1.78456018
36Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.77085496
37HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.73299833
38FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.70804850
39NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.67867666
40RUNX_20019798_ChIP-Seq_JUKART_Human1.66995381
41ZNF263_19887448_ChIP-Seq_K562_Human1.66293162
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.66223075
43IRF8_27001747_Chip-Seq_BMDM_Mouse1.64858281
44KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.63401668
45IRF8_21731497_ChIP-ChIP_J774_Mouse1.62535133
46* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.62298972
47MYC_19079543_ChIP-ChIP_MESCs_Mouse1.61781283
48PKCTHETA_26484144_Chip-Seq_BREAST_Human1.59916334
49SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.59173403
50KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.56982189
51KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.56982189
52KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.56982189
53FOXO3_23340844_ChIP-Seq_DLD1_Human1.54952789
54HIF1A_21447827_ChIP-Seq_MCF-7_Human1.54195976
55SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.53442015
56* SPI1_23547873_ChIP-Seq_NB4_Human1.52450855
57TCF3_18692474_ChIP-Seq_MEFs_Mouse1.51247196
58CHD1_26751641_Chip-Seq_LNCaP_Human1.50380083
59TCF7_22412390_ChIP-Seq_EML_Mouse1.49028584
60TFEB_21752829_ChIP-Seq_HELA_Human1.48468870
61ESR1_15608294_ChIP-ChIP_MCF-7_Human1.47124965
62WT1_19549856_ChIP-ChIP_CCG9911_Human1.46918463
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.46870698
64DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.46576269
65ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.41647105
66ELK1_19687146_ChIP-ChIP_HELA_Human1.41510967
67KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.40948848
68SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.40815552
69* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.40165948
70POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.36922050
71ZFP281_27345836_Chip-Seq_ESCs_Mouse1.33397721
72BRD4_25478319_ChIP-Seq_HGPS_Human1.32873086
73* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.32682105
74WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.31308247
75SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.30800744
76PU_27001747_Chip-Seq_BMDM_Mouse1.30436659
77BRD4_27068464_Chip-Seq_AML-cells_Mouse1.30038178
78* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.28679384
79CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.26583432
80STAT4_19710469_ChIP-ChIP_TH1__Mouse1.25869009
81SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.25422754
82SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.25422754
83TCF3_18692474_ChIP-Seq_MESCs_Mouse1.25114286
84KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24348545
85P300_27058665_Chip-Seq_ZR-75-30cells_Human1.24164051
86SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.23947993
87KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.23144047
88* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.22575733
89* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.21479866
90SCL_19346495_ChIP-Seq_HPC-7_Human1.20754385
91KDM2B_26808549_Chip-Seq_DND41_Human1.20559971
92EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.20080536
93ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.17785699
94ESR1_21235772_ChIP-Seq_MCF-7_Human1.17630119
95NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.17256240
96ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16132567
97* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.15379970
98NANOG_21062744_ChIP-ChIP_HESCs_Human1.15366062
99FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.15087677
100* ATF3_27146783_Chip-Seq_COLON_Human1.14586680
101STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13208324
102HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11026151
103UBF1/2_26484160_Chip-Seq_HMECs_Human1.09570259
104MAF_26560356_Chip-Seq_TH1_Human1.09252624
105SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.08006035
106SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07969906
107FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05832102
108TP53_16413492_ChIP-PET_HCT116_Human1.05453202
109* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.05292356
110VDR_24787735_ChIP-Seq_THP-1_Human1.04603740
111CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03370123
112EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.03199337
113KDM2B_26808549_Chip-Seq_JURKAT_Human1.03197262
114* GATA6_25053715_ChIP-Seq_YYC3_Human1.03100615
115* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.02749471
116KDM5A_27292631_Chip-Seq_BREAST_Human1.02543224
117GATA3_27048872_Chip-Seq_THYMUS_Human1.02116050
118MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.01666254
119* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01129527
120POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99700742
121PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99638408
122TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.99389012
123* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99173913
124RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97429640
125TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.96644494
126SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96543901
127TCF4_18268006_ChIP-ChIP_LS174T_Human0.96464614
128NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96002657
129SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95716212
130KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95598331
131NCOR1_26117541_ChIP-Seq_K562_Human0.95325655
132POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.94837607
133RUNX1_22412390_ChIP-Seq_EML_Mouse0.94438119
134RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.93878114
135PPAR_26484153_Chip-Seq_NCI-H1993_Human0.93492349
136* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93468183
137MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.93467823
138ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93406204
139STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.93116528
140CIITA_25753668_ChIP-Seq_RAJI_Human0.92172847
141ZFX_18555785_ChIP-Seq_MESCs_Mouse0.91397383
142SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.90882626
143TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89399095
144VDR_23849224_ChIP-Seq_CD4+_Human0.88417975
145VDR_24763502_ChIP-Seq_THP-1_Human0.84154970
146NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.83210869
147ERG_20887958_ChIP-Seq_HPC-7_Mouse0.82105669
148GATA3_26560356_Chip-Seq_TH2_Human0.81398020
149ESR1_20079471_ChIP-ChIP_T-47D_Human0.80257939
150TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.79873409
151PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78851701

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.42468283
2MP0010234_abnormal_vibrissa_follicle3.25626653
3MP0010352_gastrointestinal_tract_polyps3.20526327
4MP0005076_abnormal_cell_differentiation2.90602261
5MP0003763_abnormal_thymus_physiology2.85143278
6MP0000537_abnormal_urethra_morphology2.57567927
7MP0009053_abnormal_anal_canal2.30730246
8MP0002006_tumorigenesis2.24267884
9MP0002877_abnormal_melanocyte_morpholog2.19944864
10MP0010307_abnormal_tumor_latency2.15246594
11MP0003123_paternal_imprinting2.07070864
12MP0001835_abnormal_antigen_presentation2.04096571
13MP0004957_abnormal_blastocyst_morpholog2.02316064
14MP0003111_abnormal_nucleus_morphology1.98749685
15MP0010094_abnormal_chromosome_stability1.95434853
16MP0008057_abnormal_DNA_replication1.94386230
17MP0003077_abnormal_cell_cycle1.90371675
18MP0003300_gastrointestinal_ulcer1.89425474
19MP0002084_abnormal_developmental_patter1.88213505
20MP0001730_embryonic_growth_arrest1.86976968
21MP0003693_abnormal_embryo_hatching1.85198179
22MP0004197_abnormal_fetal_growth/weight/1.84727321
23MP0003566_abnormal_cell_adhesion1.82996667
24MP0000350_abnormal_cell_proliferation1.80237779
25MP0002086_abnormal_extraembryonic_tissu1.74367338
26MP0005380_embryogenesis_phenotype1.74007519
27MP0001672_abnormal_embryogenesis/_devel1.74007519
28MP0003828_pulmonary_edema1.73476179
29MP0010678_abnormal_skin_adnexa1.71952968
30MP0003656_abnormal_erythrocyte_physiolo1.71859808
31MP0001849_ear_inflammation1.71622677
32MP0006054_spinal_hemorrhage1.70671171
33MP0003436_decreased_susceptibility_to1.69694764
34MP0003984_embryonic_growth_retardation1.68623617
35MP0002088_abnormal_embryonic_growth/wei1.68245468
36MP0003890_abnormal_embryonic-extraembry1.67552889
37MP0003121_genomic_imprinting1.66555799
38MP0008438_abnormal_cutaneous_collagen1.66042258
39MP0003303_peritoneal_inflammation1.62166009
40MP0008007_abnormal_cellular_replicative1.60773970
41MP0003941_abnormal_skin_development1.59414272
42MP0002085_abnormal_embryonic_tissue1.59153137
43MP0000733_abnormal_muscle_development1.58668274
44MP0005187_abnormal_penis_morphology1.58292090
45MP0003724_increased_susceptibility_to1.57619427
46MP0001697_abnormal_embryo_size1.56488652
47MP0003567_abnormal_fetal_cardiomyocyte1.54571710
48MP0003937_abnormal_limbs/digits/tail_de1.54479791
49MP0003221_abnormal_cardiomyocyte_apopto1.54109942
50MP0001800_abnormal_humoral_immune1.53222903
51MP0002398_abnormal_bone_marrow1.52515585
52MP0005275_abnormal_skin_tensile1.52086058
53MP0004264_abnormal_extraembryonic_tissu1.51706994
54MP0004185_abnormal_adipocyte_glucose1.49150718
55MP0000703_abnormal_thymus_morphology1.47806419
56MP0000428_abnormal_craniofacial_morphol1.44431733
57MP0008260_abnormal_autophagy1.43095173
58MP0010030_abnormal_orbit_morphology1.42168204
59MP0000465_gastrointestinal_hemorrhage1.41936529
60MP0004947_skin_inflammation1.39828518
61MP0001851_eye_inflammation1.39483256
62MP0005000_abnormal_immune_tolerance1.38943298
63MP0002405_respiratory_system_inflammati1.37123324
64MP0005623_abnormal_meninges_morphology1.35100151
65MP0005248_abnormal_Harderian_gland1.33198456
66MP0000383_abnormal_hair_follicle1.28590288
67MP0001853_heart_inflammation1.28211598
68MP0004808_abnormal_hematopoietic_stem1.28080181
69MP0009703_decreased_birth_body1.28077471
70MP0002452_abnormal_antigen_presenting1.27592451
71MP0003935_abnormal_craniofacial_develop1.25523855
72MP0001915_intracranial_hemorrhage1.23937215
73MP0002420_abnormal_adaptive_immunity1.23296910
74MP0003115_abnormal_respiratory_system1.22746477
75MP0002723_abnormal_immune_serum1.22746105
76MP0002080_prenatal_lethality1.22510169
77MP0002722_abnormal_immune_system1.21360553
78MP0001819_abnormal_immune_cell1.21342697
79MP0002419_abnormal_innate_immunity1.21079099
80MP0002925_abnormal_cardiovascular_devel1.20683475
81MP0004272_abnormal_basement_membrane1.20230144
82MP0005023_abnormal_wound_healing1.19809819
83MP0000432_abnormal_head_morphology1.18818378
84MP0003119_abnormal_digestive_system1.18707831
85MP0002092_abnormal_eye_morphology1.18682124
86MP0000689_abnormal_spleen_morphology1.17980036
87MP0000490_abnormal_crypts_of1.17559380
88MP0003091_abnormal_cell_migration1.17106211
89MP0005621_abnormal_cell_physiology1.16059530
90MP0002009_preneoplasia1.15978077
91MP0002697_abnormal_eye_size1.15589248
92MP0009333_abnormal_splenocyte_physiolog1.14876368
93MP0000716_abnormal_immune_system1.14766980
94MP0009672_abnormal_birth_weight1.14513522
95MP0000516_abnormal_urinary_system1.10895626
96MP0005367_renal/urinary_system_phenotyp1.10895626
97MP0003385_abnormal_body_wall1.07980130
98MP0003755_abnormal_palate_morphology1.07900005
99MP0000569_abnormal_digit_pigmentation1.06615421
100MP0008058_abnormal_DNA_repair1.05445866
101MP0010155_abnormal_intestine_physiology1.04874692
102MP0009697_abnormal_copulation1.03438582
103MP0009278_abnormal_bone_marrow1.02453441
104MP0002060_abnormal_skin_morphology1.02262231
105MP0002429_abnormal_blood_cell1.01741984
106MP0002111_abnormal_tail_morphology1.01577792
107MP0001293_anophthalmia1.01529187
108MP0008932_abnormal_embryonic_tissue1.01510278
109MP0003448_altered_tumor_morphology0.98138521
110MP0003453_abnormal_keratinocyte_physiol0.98102998
111MP0009785_altered_susceptibility_to0.97781670
112MP0004782_abnormal_surfactant_physiolog0.97128379
113MP0005387_immune_system_phenotype0.96716910
114MP0001790_abnormal_immune_system0.96716910
115MP0002019_abnormal_tumor_incidence0.96652623
116MP0003172_abnormal_lysosome_physiology0.96185583
117MP0003787_abnormal_imprinting0.95804144
118MP0002896_abnormal_bone_mineralization0.95670199
119MP0000858_altered_metastatic_potential0.93535283
120MP0001299_abnormal_eye_distance/0.93406082
121MP0005671_abnormal_response_to0.92361205
122MP0003943_abnormal_hepatobiliary_system0.92332219
123MP0005451_abnormal_body_composition0.91890388
124MP0009384_cardiac_valve_regurgitation0.90250803
125MP0001286_abnormal_eye_development0.90239067
126MP0000377_abnormal_hair_follicle0.89909812
127MP0000685_abnormal_immune_system0.89640942
128MP0005025_abnormal_response_to0.89209108
129MP0000534_abnormal_ureter_morphology0.88965439
130MP0004381_abnormal_hair_follicle0.88549913
131MP0000313_abnormal_cell_death0.88405320
132MP0002396_abnormal_hematopoietic_system0.87510653
133MP0001879_abnormal_lymphatic_vessel0.86944729
134MP0005397_hematopoietic_system_phenotyp0.86562663
135MP0001545_abnormal_hematopoietic_system0.86562663
136MP0000627_abnormal_mammary_gland0.85232773
137MP0002282_abnormal_trachea_morphology0.83768463
138MP0002796_impaired_skin_barrier0.81241020
139MP0005384_cellular_phenotype0.81102760
140MP0001216_abnormal_epidermal_layer0.81091295
141MP0001191_abnormal_skin_condition0.81053668
142MP0002233_abnormal_nose_morphology0.81028831
143MP0005508_abnormal_skeleton_morphology0.80424958
144MP0002932_abnormal_joint_morphology0.80402118
145MP0008961_abnormal_basal_metabolism0.79686824
146MP0000647_abnormal_sebaceous_gland0.79600932
147MP0005409_darkened_coat_color0.79424683
148MP0010368_abnormal_lymphatic_system0.78417654
149MP0002098_abnormal_vibrissa_morphology0.76541396
150MP0005503_abnormal_tendon_morphology0.76443406
151MP0001784_abnormal_fluid_regulation0.76311280
152MP0002998_abnormal_bone_remodeling0.76068539
153MP0000767_abnormal_smooth_muscle0.74563552
154MP0005666_abnormal_adipose_tissue0.74220437
155MP0002116_abnormal_craniofacial_bone0.74118579
156MP0000266_abnormal_heart_morphology0.73767026
157MP0004084_abnormal_cardiac_muscle0.73536717
158MP0002166_altered_tumor_susceptibility0.72836471

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.52120574
2T lymphocytopenia (HP:0005403)3.40657294
3Abnormality of T cell number (HP:0011839)3.05021831
4Subacute progressive viral hepatitis (HP:0006572)3.04828163
5Acute myeloid leukemia (HP:0004808)2.95478105
6Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.95257595
7Short 4th metacarpal (HP:0010044)2.95257595
8Shallow orbits (HP:0000586)2.93691425
9Biliary tract neoplasm (HP:0100574)2.80209905
10Syringomyelia (HP:0003396)2.76876298
11Spinal cord lesions (HP:0100561)2.76876298
12Deviation of the thumb (HP:0009603)2.70783197
13Proximal placement of thumb (HP:0009623)2.63362277
14Recurrent viral infections (HP:0004429)2.62218842
15Ependymoma (HP:0002888)2.58812204
16Malignant gastrointestinal tract tumors (HP:0006749)2.53362939
17Gastrointestinal carcinoma (HP:0002672)2.53362939
18Thyroid carcinoma (HP:0002890)2.52463491
19Abnormality of oral frenula (HP:0000190)2.52360615
20Viral hepatitis (HP:0006562)2.52335100
21Autoimmune hemolytic anemia (HP:0001890)2.52046455
22Eczematoid dermatitis (HP:0000976)2.48569596
23Macroorchidism (HP:0000053)2.48536013
24Curly hair (HP:0002212)2.48270252
25Fatigue (HP:0012378)2.47011878
26Large earlobe (HP:0009748)2.45848360
27Abnormality of the fingertips (HP:0001211)2.43619951
28Colon cancer (HP:0003003)2.42494443
29Cerebral aneurysm (HP:0004944)2.41202756
30Astrocytoma (HP:0009592)2.39223385
31Abnormality of the astrocytes (HP:0100707)2.39223385
32Rectal prolapse (HP:0002035)2.36053719
33Abnormality of the 4th metacarpal (HP:0010012)2.33925366
34Increased nuchal translucency (HP:0010880)2.30883227
35Aortic aneurysm (HP:0004942)2.29614959
36Ankle contracture (HP:0006466)2.26018442
37Retrobulbar optic neuritis (HP:0100654)2.25857783
38Optic neuritis (HP:0100653)2.25857783
39Increased density of long bones (HP:0006392)2.23823478
40Hematochezia (HP:0002573)2.22668596
41Mitral valve prolapse (HP:0001634)2.22537022
42Hypoplastic labia majora (HP:0000059)2.20352804
43Persistence of primary teeth (HP:0006335)2.19260601
44Long eyelashes (HP:0000527)2.13639646
45Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.12733087
46Broad thumb (HP:0011304)2.12354328
47Keratoconjunctivitis sicca (HP:0001097)2.12349901
48Protrusio acetabuli (HP:0003179)2.10812656
49Recurrent bacterial skin infections (HP:0005406)2.08674698
50Heterotopia (HP:0002282)2.08661121
51Recurrent abscess formation (HP:0002722)2.06087943
52Selective tooth agenesis (HP:0001592)2.05399986
53Neoplasm of the oral cavity (HP:0100649)2.04522108
54Orchitis (HP:0100796)2.01318585
55Abnormal foot bone ossification (HP:0010675)2.01050304
56Enlarged penis (HP:0000040)2.00975551
57Pelvic girdle muscle weakness (HP:0003749)1.99164210
58Abnormality of the labia minora (HP:0012880)1.98512223
59Medulloblastoma (HP:0002885)1.98235140
60Spontaneous hematomas (HP:0007420)1.96059949
61Abnormality of the labia majora (HP:0012881)1.95672001
62Transitional cell carcinoma of the bladder (HP:0006740)1.92471193
63Abnormality of the nasal septum (HP:0000419)1.92409770
64Sandal gap (HP:0001852)1.92390767
65Nephroblastoma (Wilms tumor) (HP:0002667)1.92176382
66Narrow palate (HP:0000189)1.92049206
67Recurrent fungal infections (HP:0002841)1.91502411
68Uterine neoplasm (HP:0010784)1.91360730
69Rhabdomyosarcoma (HP:0002859)1.90934323
70Osteolytic defects of the phalanges of the hand (HP:0009771)1.90740647
71Osteolytic defects of the hand bones (HP:0009699)1.90740647
72Arterial thrombosis (HP:0004420)1.89708785
73Menstrual irregularities (HP:0000858)1.89572651
74Cystic hygroma (HP:0000476)1.88891742
75Hyperacusis (HP:0010780)1.88783317
76Osteomyelitis (HP:0002754)1.88064209
77Myositis (HP:0100614)1.87874344
78Esophageal atresia (HP:0002032)1.87611801
79Glioma (HP:0009733)1.87161774
80Abnormality of T cells (HP:0002843)1.86687210
81Abnormality of chromosome stability (HP:0003220)1.86543282
82Periodontitis (HP:0000704)1.86175801
83Pseudobulbar signs (HP:0002200)1.85751181
84Shawl scrotum (HP:0000049)1.85559859
85Asymmetry of the thorax (HP:0001555)1.85479532
86Papillary thyroid carcinoma (HP:0002895)1.85283739
87Renal duplication (HP:0000075)1.84418304
88Abnormality of the left ventricular outflow tract (HP:0011103)1.84240967
89Subaortic stenosis (HP:0001682)1.84240967
90Low anterior hairline (HP:0000294)1.83814336
91Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.83167255
92Facial hemangioma (HP:0000329)1.83005207
93Myelodysplasia (HP:0002863)1.82697577
94Truncal obesity (HP:0001956)1.82556659
95Gastrointestinal infarctions (HP:0005244)1.81895460
96Thickened calvaria (HP:0002684)1.81525952
97Wrist flexion contracture (HP:0001239)1.80910694
98Amaurosis fugax (HP:0100576)1.80453558
99Keratoconjunctivitis (HP:0001096)1.79390541
100Disinhibition (HP:0000734)1.79349292
101Embryonal renal neoplasm (HP:0011794)1.79001383
102Neoplasm of the tracheobronchial system (HP:0100552)1.78758446
103Bowel diverticulosis (HP:0005222)1.78437514
104Bladder neoplasm (HP:0009725)1.78323426
105Bladder carcinoma (HP:0002862)1.78323426
106Neoplasm of the small intestine (HP:0100833)1.77748448
107Lip pit (HP:0100267)1.77540160
108Short 1st metacarpal (HP:0010034)1.76471406
109Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.76471406
110Obsessive-compulsive behavior (HP:0000722)1.75771059
111Chest pain (HP:0100749)1.74736832
112IgM deficiency (HP:0002850)1.74205242
113Genu recurvatum (HP:0002816)1.74129949
114Micronodular cirrhosis (HP:0001413)1.74012260
115Uterine leiomyosarcoma (HP:0002891)1.73930858
116Leiomyosarcoma (HP:0100243)1.73930858
117Combined immunodeficiency (HP:0005387)1.73920350
118Deviation of the hallux (HP:0010051)1.73494378
119Bicuspid aortic valve (HP:0001647)1.73146245
120Deep philtrum (HP:0002002)1.72815380
121Somatic mutation (HP:0001428)1.72259459
122Fibrous tissue neoplasm (HP:0012316)1.72142553
123Severe combined immunodeficiency (HP:0004430)1.71729773
124Arterial tortuosity (HP:0005116)1.71457323
125Cutis marmorata (HP:0000965)1.71000675
126Urethral obstruction (HP:0000796)1.70842389
127Dilatation of the ascending aorta (HP:0005111)1.70809591
128Inflammation of the large intestine (HP:0002037)1.70704798
129Hallux valgus (HP:0001822)1.70377466
130Skull defect (HP:0001362)1.70245497
131Blepharitis (HP:0000498)1.69819302
132Prominent nose (HP:0000448)1.69661151
133Broad phalanges of the hand (HP:0009768)1.69234290
134Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.69045409
135Aneurysm (HP:0002617)1.68358752
136Aortic dissection (HP:0002647)1.68029229
137Exostoses (HP:0100777)1.67473847
138Neoplasm of the rectum (HP:0100743)1.66818707
139Lymphoma (HP:0002665)1.66771981
140Abnormal biliary tract morphology (HP:0012440)1.66452083
141Shoulder girdle muscle weakness (HP:0003547)1.66297476
142Supernumerary ribs (HP:0005815)1.66221210
143Missing ribs (HP:0000921)1.66208652
144Recurrent cutaneous fungal infections (HP:0011370)1.66189152
145Chronic mucocutaneous candidiasis (HP:0002728)1.66189152
146Insidious onset (HP:0003587)1.66112715
147Termporal pattern (HP:0011008)1.66112715
148Neoplasm of striated muscle (HP:0009728)1.65954171
149Renovascular hypertension (HP:0100817)1.65865725
150Chromosomal breakage induced by crosslinking agents (HP:0003221)1.65863678
151Ankyloglossia (HP:0010296)1.64721787
152Submucous cleft hard palate (HP:0000176)1.63624894
153Abnormality of the distal phalanx of the thumb (HP:0009617)1.63548723
154Absent frontal sinuses (HP:0002688)1.63429527
155Gastrointestinal inflammation (HP:0004386)1.63146204
156Vertebral arch anomaly (HP:0008438)1.63023342
157Fibroma (HP:0010614)1.62912495
158Coarse hair (HP:0002208)1.62743536
159Sparse lateral eyebrow (HP:0005338)1.62698855
160High pitched voice (HP:0001620)1.62514709
161Freckling (HP:0001480)1.62295915
162Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.61752583
163Abnormal delayed hypersensitivity skin test (HP:0002963)1.61752154
164Abnormal platelet volume (HP:0011876)1.61455681
165Relative macrocephaly (HP:0004482)1.61248913
166Abnormality of the hip-girdle musculature (HP:0001445)1.60945664
167Abnormality of the musculature of the pelvis (HP:0001469)1.60945664

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS13.90276038
2CDK123.43108244
3MAP3K143.36193299
4CDC72.93417974
5EEF2K2.89732851
6EIF2AK32.72511839
7PKN22.53915106
8PRPF4B2.52556217
9TRIB32.11616932
10SIK32.07441450
11RIPK12.05117245
12PDGFRA2.04549418
13STK32.01732440
14STK101.94448513
15CDK61.92172579
16SCYL21.89262105
17MAP3K101.87444998
18PTK61.84780992
19YES11.84742593
20NEK21.78768899
21MKNK11.78560075
22ALK1.76108043
23RPS6KB21.64357425
24TSSK61.64356131
25BMPR21.63450339
26FGFR21.59539917
27LATS21.57612406
28JAK11.49853902
29WEE11.46903233
30FRK1.44056656
31MKNK21.43989545
32EPHA21.43404032
33TTK1.43053031
34TGFBR11.41924717
35TTN1.41025278
36IRAK11.40386819
37FGFR31.39340280
38IKBKE1.33014472
39ACVR1B1.32387475
40CAMK1D1.31399227
41TRIM281.28991625
42PDGFRB1.28385774
43MTOR1.28305526
44SRPK11.27927006
45NEK61.27455794
46MST41.26857215
47PLK31.26799267
48FGFR11.26607676
49BRD41.25784517
50CDK41.22220814
51IRAK21.21368069
52MELK1.20649435
53CSK1.20082765
54NLK1.18269615
55PAK21.15134654
56MAP3K81.13331166
57EIF2AK21.12070430
58IRAK41.10583223
59LRRK21.08472118
60BCR1.07040657
61RPS6KA41.06854509
62SMG11.06022544
63PNCK1.04703855
64NEK11.03493445
65PASK1.02759431
66PAK41.01667151
67MAP3K131.01470995
68ERBB31.00267369
69CHEK10.99782824
70CLK10.96261360
71BRSK20.95917300
72JAK30.95480434
73CAMK1G0.95361034
74HCK0.94451159
75FES0.92966698
76TYK20.92681827
77CDK30.92637747
78ATM0.91807385
79AKT30.91414927
80MET0.89858975
81CDK90.88195808
82FER0.87575002
83RET0.85346043
84TGFBR20.85079922
85DDR20.84828749
86TEC0.84500687
87ATR0.82981974
88* AURKB0.82814865
89MAP2K30.81524357
90FGFR40.79401300
91EPHA30.78680842
92* CDK20.77785760
93TXK0.77280701
94GRK60.76753068
95MAP3K20.75558375
96MAPK70.72002487
97PLK10.71510616
98PDK20.71186606
99SGK30.70626294
100CSNK1D0.68347974
101CSNK1E0.67010931
102DMPK0.66644042
103RIPK40.65543249
104PTK20.65449149
105BMX0.65124516
106BTK0.64246809
107JAK20.63585008
108TYRO30.63159468
109CSNK1A1L0.62143049
110MAP4K10.61908355
111CDK70.61891862
112DYRK30.60518436
113GSK3A0.60142689
114ERBB40.59523400
115* CDK10.59036156
116CHEK20.57507457
117STK38L0.57200687
118NEK90.57153765
119EIF2AK10.57095627
120TRPM70.56845497
121TAF10.55925134
122FGR0.55649280
123PIK3CG0.55335267
124FLT30.55285783
125NUAK10.54583654
126SIK10.53784565
127MAPK140.53016358
128MAP3K50.52969045
129STK240.52400100
130SGK20.52063757
131TBK10.51148139
132MAP3K30.50941611
133SYK0.50636913
134PRKDC0.50474082
135BLK0.49927677
136IRAK30.49653176
137HIPK20.49204712
138CHUK0.49133141
139EGFR0.48856660
140PBK0.48581608
141CSNK1G10.48489843
142EPHB20.47196084
143ERBB20.46084392
144PIM10.46075119
145MAPK10.43746795
146KSR10.42454132
147MAPK100.41998968
148AKT10.40819254
149ITK0.37862355
150STK40.36666490
151GSK3B0.35577839
152KSR20.33261154

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041102.17153999
2MicroRNAs in cancer_Homo sapiens_hsa052062.08399939
3Adherens junction_Homo sapiens_hsa045202.08376552
4RNA transport_Homo sapiens_hsa030132.08337010
5Measles_Homo sapiens_hsa051621.90089366
6Small cell lung cancer_Homo sapiens_hsa052221.86154239
7Chronic myeloid leukemia_Homo sapiens_hsa052201.83637963
8Hippo signaling pathway_Homo sapiens_hsa043901.79183202
9TGF-beta signaling pathway_Homo sapiens_hsa043501.76726199
10Spliceosome_Homo sapiens_hsa030401.75731699
11Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.75179092
12Colorectal cancer_Homo sapiens_hsa052101.68036858
13mRNA surveillance pathway_Homo sapiens_hsa030151.65920690
14Legionellosis_Homo sapiens_hsa051341.63460150
15Proteoglycans in cancer_Homo sapiens_hsa052051.62655268
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.61694427
17Basal cell carcinoma_Homo sapiens_hsa052171.53618624
18One carbon pool by folate_Homo sapiens_hsa006701.53049729
19Leishmaniasis_Homo sapiens_hsa051401.51922373
20mTOR signaling pathway_Homo sapiens_hsa041501.51515687
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.50654071
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.48920697
23Influenza A_Homo sapiens_hsa051641.47381978
24Prostate cancer_Homo sapiens_hsa052151.44125455
25Focal adhesion_Homo sapiens_hsa045101.43369525
26* Viral carcinogenesis_Homo sapiens_hsa052031.39701506
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.38977399
28Endometrial cancer_Homo sapiens_hsa052131.38833685
29Lysine degradation_Homo sapiens_hsa003101.36420464
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.35549212
31Pancreatic cancer_Homo sapiens_hsa052121.34422071
32Nitrogen metabolism_Homo sapiens_hsa009101.34087737
33Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.32187042
34Thyroid cancer_Homo sapiens_hsa052161.30855581
35p53 signaling pathway_Homo sapiens_hsa041151.29756624
36ECM-receptor interaction_Homo sapiens_hsa045121.28889008
37HTLV-I infection_Homo sapiens_hsa051661.28390692
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.27947971
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.27231083
40Renal cell carcinoma_Homo sapiens_hsa052111.25976566
41* RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.25323368
42Toll-like receptor signaling pathway_Homo sapiens_hsa046201.25074817
43Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.24538453
44Transcriptional misregulation in cancer_Homo sapiens_hsa052021.19796722
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.17571728
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.15000790
47Thyroid hormone signaling pathway_Homo sapiens_hsa049191.12255114
48Non-small cell lung cancer_Homo sapiens_hsa052231.12143653
49Dorso-ventral axis formation_Homo sapiens_hsa043201.12048068
50Notch signaling pathway_Homo sapiens_hsa043301.11265579
51Shigellosis_Homo sapiens_hsa051311.11176809
52Antigen processing and presentation_Homo sapiens_hsa046121.07244070
53Wnt signaling pathway_Homo sapiens_hsa043101.06959798
54Hepatitis C_Homo sapiens_hsa051601.06820117
55Leukocyte transendothelial migration_Homo sapiens_hsa046701.06521060
56FoxO signaling pathway_Homo sapiens_hsa040681.06173986
57Pathways in cancer_Homo sapiens_hsa052001.05727386
58Tight junction_Homo sapiens_hsa045301.04216199
59Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03619041
60RNA degradation_Homo sapiens_hsa030181.02944508
61Systemic lupus erythematosus_Homo sapiens_hsa053221.02206548
62Central carbon metabolism in cancer_Homo sapiens_hsa052301.01238246
63Bladder cancer_Homo sapiens_hsa052191.01113066
64Inositol phosphate metabolism_Homo sapiens_hsa005621.00134384
65Hedgehog signaling pathway_Homo sapiens_hsa043400.99249671
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.98524171
67Tuberculosis_Homo sapiens_hsa051520.97501045
68Mismatch repair_Homo sapiens_hsa034300.97345812
69Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.96294360
70Oocyte meiosis_Homo sapiens_hsa041140.96223570
71Estrogen signaling pathway_Homo sapiens_hsa049150.95079174
72Glioma_Homo sapiens_hsa052140.95033894
73Prolactin signaling pathway_Homo sapiens_hsa049170.92612118
74Non-homologous end-joining_Homo sapiens_hsa034500.91011554
75Viral myocarditis_Homo sapiens_hsa054160.90259134
76Amoebiasis_Homo sapiens_hsa051460.87010740
77Toxoplasmosis_Homo sapiens_hsa051450.86966232
78DNA replication_Homo sapiens_hsa030300.86767359
79Insulin resistance_Homo sapiens_hsa049310.85344695
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85339731
81Primary immunodeficiency_Homo sapiens_hsa053400.84094175
82* Hepatitis B_Homo sapiens_hsa051610.83251665
83Selenocompound metabolism_Homo sapiens_hsa004500.82583028
84Malaria_Homo sapiens_hsa051440.82210199
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.81832829
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78884581
87Graft-versus-host disease_Homo sapiens_hsa053320.77565106
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76865408
89Herpes simplex infection_Homo sapiens_hsa051680.76796776
90Platelet activation_Homo sapiens_hsa046110.76184586
91Melanoma_Homo sapiens_hsa052180.76136651
92Chemokine signaling pathway_Homo sapiens_hsa040620.75726133
93Allograft rejection_Homo sapiens_hsa053300.75665969
94PI3K-Akt signaling pathway_Homo sapiens_hsa041510.74175494
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73884184
96Acute myeloid leukemia_Homo sapiens_hsa052210.72258193
97Circadian rhythm_Homo sapiens_hsa047100.71489116
98Hematopoietic cell lineage_Homo sapiens_hsa046400.71333294
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71162153
100VEGF signaling pathway_Homo sapiens_hsa043700.70191766
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.69934590
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69614951
103Apoptosis_Homo sapiens_hsa042100.69285946
104Epstein-Barr virus infection_Homo sapiens_hsa051690.69245174
105AMPK signaling pathway_Homo sapiens_hsa041520.69125817
106Autoimmune thyroid disease_Homo sapiens_hsa053200.67732386
107Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66391206
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66124654
109HIF-1 signaling pathway_Homo sapiens_hsa040660.66116179
110T cell receptor signaling pathway_Homo sapiens_hsa046600.65894676
111ErbB signaling pathway_Homo sapiens_hsa040120.64990864
112TNF signaling pathway_Homo sapiens_hsa046680.64495407
113Rap1 signaling pathway_Homo sapiens_hsa040150.62936732
114Type I diabetes mellitus_Homo sapiens_hsa049400.61011179
115Osteoclast differentiation_Homo sapiens_hsa043800.59483771
116Basal transcription factors_Homo sapiens_hsa030220.58820035
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57774920
118Type II diabetes mellitus_Homo sapiens_hsa049300.57746724
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.56879597
120Melanogenesis_Homo sapiens_hsa049160.55321958
121Insulin signaling pathway_Homo sapiens_hsa049100.53708932
122Protein digestion and absorption_Homo sapiens_hsa049740.53599738
123Nucleotide excision repair_Homo sapiens_hsa034200.53060859
124Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52628046
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52435985
126Cyanoamino acid metabolism_Homo sapiens_hsa004600.52169421
127Choline metabolism in cancer_Homo sapiens_hsa052310.50882300
128B cell receptor signaling pathway_Homo sapiens_hsa046620.49969135
129MAPK signaling pathway_Homo sapiens_hsa040100.49270974
130Glucagon signaling pathway_Homo sapiens_hsa049220.49077219
131Thyroid hormone synthesis_Homo sapiens_hsa049180.48107360

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