DDX4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a homolog of VASA proteins in Drosophila and several other species. The gene is specifically expressed in the germ cell lineage in both sexes and functions in germ cell development. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)8.49736574
2chromosome organization involved in meiosis (GO:0070192)8.36708026
3regulation of meiosis I (GO:0060631)8.06055523
4fusion of sperm to egg plasma membrane (GO:0007342)7.80480444
5* meiotic nuclear division (GO:0007126)7.71498918
6sperm-egg recognition (GO:0035036)6.51069621
7* male meiosis I (GO:0007141)6.41216002
8binding of sperm to zona pellucida (GO:0007339)6.39698242
9* sperm motility (GO:0030317)6.16064739
10spermatid development (GO:0007286)6.15857142
11histone H3-K9 demethylation (GO:0033169)6.09836789
12gene silencing by RNA (GO:0031047)6.09101397
13acrosome assembly (GO:0001675)5.86763831
14cell-cell recognition (GO:0009988)5.82989423
15axonemal dynein complex assembly (GO:0070286)5.82727213
16plasma membrane fusion (GO:0045026)5.82725393
17multicellular organism reproduction (GO:0032504)5.79911770
18meiotic chromosome segregation (GO:0045132)5.40005169
19* meiotic cell cycle process (GO:1903046)5.38438918
20epithelial cilium movement (GO:0003351)5.36375002
21* meiosis I (GO:0007127)5.31755050
22DNA alkylation (GO:0006305)5.28457819
23DNA methylation (GO:0006306)5.28457819
24nuclear pore complex assembly (GO:0051292)5.12274308
25germ cell development (GO:0007281)4.89748984
26acrosome reaction (GO:0007340)4.87596104
27reciprocal DNA recombination (GO:0035825)4.83458943
28reciprocal meiotic recombination (GO:0007131)4.83458943
29meiotic cell cycle (GO:0051321)4.82653082
30epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.81224546
31regulation of meiotic cell cycle (GO:0051445)4.80169103
32nuclear pore organization (GO:0006999)4.75327020
33motile cilium assembly (GO:0044458)4.73534701
34reproduction (GO:0000003)4.63168821
35* spermatogenesis (GO:0007283)4.62760598
36* male gamete generation (GO:0048232)4.62260812
37cilium movement (GO:0003341)4.59396890
38positive regulation of meiosis (GO:0045836)4.53168030
39oogenesis (GO:0048477)4.47597822
40fertilization (GO:0009566)4.45686021
41synapsis (GO:0007129)4.44986719
42sister chromatid cohesion (GO:0007062)4.44325024
43cell wall macromolecule catabolic process (GO:0016998)4.36150122
44cell wall macromolecule metabolic process (GO:0044036)4.36150122
45microtubule depolymerization (GO:0007019)4.36008917
46gene silencing (GO:0016458)4.30370268
47* gamete generation (GO:0007276)4.30159147
48positive regulation of meiotic cell cycle (GO:0051446)4.26493195
49cellular process involved in reproduction in multicellular organism (GO:0022412)4.25793978
50resolution of meiotic recombination intermediates (GO:0000712)4.21416691
51regulation of cilium movement (GO:0003352)4.18391531
52DNA methylation or demethylation (GO:0044728)4.09081744
53positive regulation of translational initiation (GO:0045948)4.09042971
54DNA synthesis involved in DNA repair (GO:0000731)4.06267253
55single fertilization (GO:0007338)4.00206094
56monoubiquitinated protein deubiquitination (GO:0035520)3.97007802
57histone H3-K36 demethylation (GO:0070544)3.94039089
58heterochromatin organization (GO:0070828)3.92349460
59negative regulation of meiosis (GO:0045835)3.90321163
60pore complex assembly (GO:0046931)3.84753639
61centriole assembly (GO:0098534)3.74808717
62regulation of centriole replication (GO:0046599)3.73396288
63negative regulation of gene silencing (GO:0060969)3.68873748
64DNA replication-dependent nucleosome organization (GO:0034723)3.68275356
65DNA replication-dependent nucleosome assembly (GO:0006335)3.68275356
66attachment of spindle microtubules to kinetochore (GO:0008608)3.67528498
67protein localization to chromosome (GO:0034502)3.65774540
68histone exchange (GO:0043486)3.64891681
69oocyte development (GO:0048599)3.54245797
70mitotic sister chromatid cohesion (GO:0007064)3.51885950
71sex differentiation (GO:0007548)3.49860973
72regulation of histone H3-K9 methylation (GO:0051570)3.47437566
73female gamete generation (GO:0007292)3.45926156
74DNA packaging (GO:0006323)3.43983278
75regulation of DNA endoreduplication (GO:0032875)3.43950214
76DNA modification (GO:0006304)3.43391832
77genitalia morphogenesis (GO:0035112)3.39855504
78oocyte maturation (GO:0001556)3.39121888
79negative regulation of inclusion body assembly (GO:0090084)3.37185559
80* multicellular organismal reproductive process (GO:0048609)3.31994726
81chromosome organization (GO:0051276)3.26879684
82DNA biosynthetic process (GO:0071897)3.25668747
83gonadal mesoderm development (GO:0007506)3.21690037
84seminiferous tubule development (GO:0072520)3.19905619
85histone lysine demethylation (GO:0070076)3.19084698
86mitotic chromosome condensation (GO:0007076)3.18918244
87translesion synthesis (GO:0019985)3.15794332
88ventricular system development (GO:0021591)3.14165080
89sperm capacitation (GO:0048240)3.12330621
90regulation of protein polyubiquitination (GO:1902914)3.11920076
91chromosome condensation (GO:0030261)3.10517984
92protein K6-linked ubiquitination (GO:0085020)3.08827498
93nucleus organization (GO:0006997)3.08049195
94histone demethylation (GO:0016577)3.07338263
95proteasome assembly (GO:0043248)3.07265793
96regulation of meiosis (GO:0040020)3.06616436
97chromatin remodeling at centromere (GO:0031055)3.01792665
98embryonic body morphogenesis (GO:0010172)3.00761804
99* nuclear division (GO:0000280)2.99106474
100chaperone-mediated protein complex assembly (GO:0051131)2.98262762
101histone H2A acetylation (GO:0043968)2.98167889
102regulation of chromosome segregation (GO:0051983)2.96646041
103negative regulation of DNA repair (GO:0045738)2.93741333
104kinetochore organization (GO:0051383)2.92339850
105intra-S DNA damage checkpoint (GO:0031573)2.90301828
106negative regulation of meiotic cell cycle (GO:0051447)2.88076818
107protein targeting to Golgi (GO:0000042)2.86828037
108interkinetic nuclear migration (GO:0022027)2.86689055
109mitotic metaphase plate congression (GO:0007080)2.86283906
110negative regulation of organelle assembly (GO:1902116)2.85822298
111reproductive system development (GO:0061458)2.84892122
112protein dealkylation (GO:0008214)2.82598777
113protein demethylation (GO:0006482)2.82598777
114regulation of spindle checkpoint (GO:0090231)2.81264480
115single strand break repair (GO:0000012)2.79675676
116spermatid nucleus differentiation (GO:0007289)2.77511273
117centriole replication (GO:0007099)2.76841696
118* organelle fission (GO:0048285)2.76753336
119establishment of protein localization to Golgi (GO:0072600)2.72680381
120mitotic spindle assembly checkpoint (GO:0007094)2.68471635
121negative regulation of histone methylation (GO:0031061)2.66810626
122regulation of female gonad development (GO:2000194)2.64372779
123CENP-A containing nucleosome assembly (GO:0034080)2.63854480
124spindle assembly checkpoint (GO:0071173)2.62503080
125piRNA metabolic process (GO:0034587)15.3002220
126synaptonemal complex assembly (GO:0007130)11.8676161
127synaptonemal complex organization (GO:0070193)11.5953559
128DNA methylation involved in gamete generation (GO:0043046)11.5515513
129male meiosis (GO:0007140)10.9135824

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.38158305
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.65334345
3IGF1R_20145208_ChIP-Seq_DFB_Human3.36497543
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.06793954
5RBPJ_22232070_ChIP-Seq_NCS_Mouse2.89373344
6* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.86304808
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.74518310
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.71765068
9BMI1_23680149_ChIP-Seq_NPCS_Mouse2.39147008
10KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.33920933
11AR_21909140_ChIP-Seq_LNCAP_Human2.23680560
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.08132122
13MYCN_18555785_ChIP-Seq_MESCs_Mouse2.06345922
14* MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.05537602
15EZH2_22144423_ChIP-Seq_EOC_Human2.02141288
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.9376364
17GATA1_26923725_Chip-Seq_HPCs_Mouse1.97631626
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.90219128
19ER_23166858_ChIP-Seq_MCF-7_Human1.80789674
20UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.75281387
21E2F1_21310950_ChIP-Seq_MCF-7_Human1.74883891
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.70865724
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.70526784
24PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68886157
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63563647
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62736221
27BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.61363918
28RUNX2_22187159_ChIP-Seq_PCA_Human1.60448750
29TAF15_26573619_Chip-Seq_HEK293_Human1.60028765
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.59916268
31RNF2_27304074_Chip-Seq_NSC_Mouse1.57448766
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.56768058
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.53450689
34CBP_20019798_ChIP-Seq_JUKART_Human1.52033309
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52033309
36SMAD4_21741376_ChIP-Seq_EPCs_Human1.51454778
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.48680559
38TP63_19390658_ChIP-ChIP_HaCaT_Human1.47944414
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.46662547
40AR_25329375_ChIP-Seq_VCAP_Human1.45803075
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.45436878
42BCAT_22108803_ChIP-Seq_LS180_Human1.43827433
43CREB1_15753290_ChIP-ChIP_HEK293T_Human1.43734799
44NELFA_20434984_ChIP-Seq_ESCs_Mouse1.43098150
45TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42892380
46POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.42892380
47VDR_22108803_ChIP-Seq_LS180_Human1.41586825
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40263240
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39517117
50STAT3_23295773_ChIP-Seq_U87_Human1.38234683
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38103555
52CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.38038421
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36993190
54PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.36899138
55RUNX1_26923725_Chip-Seq_HPCs_Mouse1.36158907
56MYC_19030024_ChIP-ChIP_MESCs_Mouse1.35618749
57RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.34136035
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.33439781
59FOXA1_21572438_ChIP-Seq_LNCaP_Human1.32553962
60MYC_18358816_ChIP-ChIP_MESCs_Mouse1.31310260
61CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30975936
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30685606
63FOXH1_21741376_ChIP-Seq_EPCs_Human1.29276086
64TCF4_23295773_ChIP-Seq_U87_Human1.29231837
65KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27462161
66MYC_19079543_ChIP-ChIP_MESCs_Mouse1.25957088
67EST1_17652178_ChIP-ChIP_JURKAT_Human1.25238307
68* ERA_21632823_ChIP-Seq_H3396_Human1.25082337
69VDR_23849224_ChIP-Seq_CD4+_Human1.24037181
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23069770
71JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.22450328
72CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.22441483
73* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21522761
74TP53_22573176_ChIP-Seq_HFKS_Human1.21140345
75PRDM14_20953172_ChIP-Seq_ESCs_Human1.17053800
76DCP1A_22483619_ChIP-Seq_HELA_Human1.16368388
77XRN2_22483619_ChIP-Seq_HELA_Human1.14989960
78ELK4_26923725_Chip-Seq_MESODERM_Mouse1.14651318
79P300_19829295_ChIP-Seq_ESCs_Human1.14614452
80EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13796936
81GABP_19822575_ChIP-Seq_HepG2_Human1.13664888
82EWS_26573619_Chip-Seq_HEK293_Human1.13258384
83FOXA1_25329375_ChIP-Seq_VCAP_Human1.12650878
84FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12650878
85TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.11338497
86* GATA3_26560356_Chip-Seq_TH1_Human1.11221986
87FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11073458
88PKCTHETA_26484144_Chip-Seq_BREAST_Human1.11060743
89GABP_17652178_ChIP-ChIP_JURKAT_Human1.10983431
90E2F1_17053090_ChIP-ChIP_MCF-7_Human1.09682116
91HOXB7_26014856_ChIP-Seq_BT474_Human1.08672664
92GATA3_21867929_ChIP-Seq_TH1_Mouse1.08665294
93KDM5A_27292631_Chip-Seq_BREAST_Human1.08107192
94SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06886705
95CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06460915
96KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05472570
97ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05124302
98CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05005493
99KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.04914603
100FOXP3_21729870_ChIP-Seq_TREG_Human1.04577034
101SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.03981438
102AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03844767
103TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.03258637
104E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02903876
105CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.02031632
106KAP1_22055183_ChIP-Seq_ESCs_Mouse1.00946307
107ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00256069
108SMAD4_21799915_ChIP-Seq_A2780_Human0.99900141
109HTT_18923047_ChIP-ChIP_STHdh_Human0.98106700
110ETS1_20019798_ChIP-Seq_JURKAT_Human0.98079904
111ETV1_20927104_ChIP-Seq_GIST48_Human0.97945940
112VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97340094
113NFE2_27457419_Chip-Seq_LIVER_Mouse0.97276537
114HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.96823816
115* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96209310
116SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96045972
117NANOG_19829295_ChIP-Seq_ESCs_Human0.95131497
118SOX2_19829295_ChIP-Seq_ESCs_Human0.95131497
119GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94013263
120MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93924762
121RAC3_21632823_ChIP-Seq_H3396_Human0.93780782
122* MYC_19829295_ChIP-Seq_ESCs_Human0.93776456
123HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.93650197
124STAT1_17558387_ChIP-Seq_HELA_Human0.93642477
125KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.93455843
126KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.93455843
127KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.93455843
128PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93210194
129FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.90334108
130WDR5_24793694_ChIP-Seq_LNCAP_Human0.89167019
131GATA3_21867929_ChIP-Seq_CD8_Mouse0.88368245
132STAT6_21828071_ChIP-Seq_BEAS2B_Human0.87562604
133GATA3_21878914_ChIP-Seq_MCF-7_Human0.85347792
134OCT4_20526341_ChIP-Seq_ESCs_Human0.84736010
135TTF2_22483619_ChIP-Seq_HELA_Human0.84495477
136SOX2_22085726_ChIP-Seq_NPCs_Mouse0.84123275
137ERG_20517297_ChIP-Seq_VCAP_Human0.84085835
138LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.83541924
139YY1_22570637_ChIP-Seq_MALME-3M_Human0.82887821
140STAT3_1855785_ChIP-Seq_MESCs_Mouse0.82398456
141YY1_21170310_ChIP-Seq_MESCs_Mouse0.80545413
142KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.79990931
143SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.77704394
144GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.77252857
145FUS_26573619_Chip-Seq_HEK293_Human0.77160755
146RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.77059909
147TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.75996138
148EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.75774073
149EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.75647250
150CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.75597685
151FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.74128805
152TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.73595155
153P53_21459846_ChIP-Seq_SAOS-2_Human0.73453281
154SUZ12_27294783_Chip-Seq_NPCs_Mouse0.72841957
155* SOX2_21211035_ChIP-Seq_LN229_Human0.72539530
156CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.72403503
157* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.68699779
158DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.68408600
159MYC_18940864_ChIP-ChIP_HL60_Human0.67559343
160GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.66794182
161ZNF274_21170338_ChIP-Seq_K562_Hela0.66640472
162TAL1_26923725_Chip-Seq_HPCs_Mouse0.66555818

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation9.70297216
2MP0005410_abnormal_fertilization7.62273437
3* MP0001929_abnormal_gametogenesis5.08959801
4MP0008995_early_reproductive_senescence4.87958463
5* MP0002210_abnormal_sex_determination4.83251050
6* MP0003698_abnormal_male_reproductive4.69763406
7* MP0001145_abnormal_male_reproductive3.92773921
8MP0008057_abnormal_DNA_replication3.75851416
9MP0010094_abnormal_chromosome_stability3.67527585
10* MP0000653_abnormal_sex_gland3.50673289
11MP0008058_abnormal_DNA_repair3.45111525
12MP0003786_premature_aging3.43745127
13* MP0002161_abnormal_fertility/fecundity2.68208438
14MP0003111_abnormal_nucleus_morphology2.56175409
15MP0000678_abnormal_parathyroid_gland2.40716780
16MP0003077_abnormal_cell_cycle2.19283845
17MP0008007_abnormal_cellular_replicative2.16474811
18MP0008789_abnormal_olfactory_epithelium2.07499513
19MP0003123_paternal_imprinting2.06721031
20MP0003693_abnormal_embryo_hatching2.05541618
21MP0004957_abnormal_blastocyst_morpholog1.98305223
22MP0010368_abnormal_lymphatic_system1.96637936
23MP0002160_abnormal_reproductive_system1.92763272
24MP0006292_abnormal_olfactory_placode1.79202691
25MP0002653_abnormal_ependyma_morphology1.62083405
26MP0001119_abnormal_female_reproductive1.49047927
27MP0005499_abnormal_olfactory_system1.45939294
28MP0005394_taste/olfaction_phenotype1.45939294
29MP0001730_embryonic_growth_arrest1.45509336
30MP0003183_abnormal_peptide_metabolism1.42678940
31MP0004808_abnormal_hematopoietic_stem1.38719267
32MP0008004_abnormal_stomach_pH1.33149976
33MP0010030_abnormal_orbit_morphology1.32974538
34MP0010307_abnormal_tumor_latency1.26850567
35MP0003878_abnormal_ear_physiology1.25896302
36MP0005377_hearing/vestibular/ear_phenot1.25896302
37MP0008932_abnormal_embryonic_tissue1.25476174
38MP0005623_abnormal_meninges_morphology1.20342357
39MP0003699_abnormal_female_reproductive1.14087476
40MP0005647_abnormal_sex_gland1.13289095
41MP0000350_abnormal_cell_proliferation1.09088992
42MP0003890_abnormal_embryonic-extraembry1.08237049
43MP0005389_reproductive_system_phenotype1.07628292
44MP0003121_genomic_imprinting1.00166321
45MP0010352_gastrointestinal_tract_polyps0.95455124
46MP0002139_abnormal_hepatobiliary_system0.93519216
47MP0001697_abnormal_embryo_size0.88841536
48MP0005174_abnormal_tail_pigmentation0.85800454
49MP0003646_muscle_fatigue0.85125328
50MP0005380_embryogenesis_phenotype0.84419721
51MP0001672_abnormal_embryogenesis/_devel0.84419721
52MP0000383_abnormal_hair_follicle0.83615606
53MP0002084_abnormal_developmental_patter0.83000366
54* MP0000313_abnormal_cell_death0.80633259
55MP0001188_hyperpigmentation0.80409753
56MP0004197_abnormal_fetal_growth/weight/0.78858697
57MP0003787_abnormal_imprinting0.78534278
58MP0002085_abnormal_embryonic_tissue0.77857123
59MP0001984_abnormal_olfaction0.76392390
60MP0000015_abnormal_ear_pigmentation0.76382641
61MP0003879_abnormal_hair_cell0.74437389
62MP0002249_abnormal_larynx_morphology0.73997960
63MP0002019_abnormal_tumor_incidence0.73276363
64MP0003984_embryonic_growth_retardation0.72262345
65MP0002080_prenatal_lethality0.71205603
66MP0008260_abnormal_autophagy0.70115283
67MP0002234_abnormal_pharynx_morphology0.67604427
68MP0002088_abnormal_embryonic_growth/wei0.66508909
69MP0010678_abnormal_skin_adnexa0.63883372
70MP0009672_abnormal_birth_weight0.62956224
71MP0002095_abnormal_skin_pigmentation0.62379619
72MP0001293_anophthalmia0.62081006
73MP0005397_hematopoietic_system_phenotyp0.61754106
74MP0001545_abnormal_hematopoietic_system0.61754106
75MP0000569_abnormal_digit_pigmentation0.61252682
76MP0004233_abnormal_muscle_weight0.60896678
77MP0000631_abnormal_neuroendocrine_gland0.60886351
78MP0005670_abnormal_white_adipose0.59659436
79MP0002233_abnormal_nose_morphology0.58398936
80MP0003718_maternal_effect0.57858721
81MP0005551_abnormal_eye_electrophysiolog0.56979336
82MP0002282_abnormal_trachea_morphology0.56666344
83MP0005076_abnormal_cell_differentiation0.56393296
84MP0003936_abnormal_reproductive_system0.56351995
85MP0003950_abnormal_plasma_membrane0.55515576
86MP0003115_abnormal_respiratory_system0.55422457
87MP0003315_abnormal_perineum_morphology0.53122337
88MP0000427_abnormal_hair_cycle0.52546034
89MP0002086_abnormal_extraembryonic_tissu0.52456541
90MP0000358_abnormal_cell_content/0.52325753
91MP0005423_abnormal_somatic_nervous0.51911678
92MP0006035_abnormal_mitochondrial_morpho0.51209367
93MP0002735_abnormal_chemical_nociception0.50615111
94MP0001486_abnormal_startle_reflex0.50602250
95MP0001879_abnormal_lymphatic_vessel0.49687314
96MP0005310_abnormal_salivary_gland0.48872343
97MP0000049_abnormal_middle_ear0.48020406
98MP0000778_abnormal_nervous_system0.47989708
99MP0001963_abnormal_hearing_physiology0.47379056
100MP0002396_abnormal_hematopoietic_system0.45419366
101MP0001666_abnormal_nutrient_absorption0.45364278
102MP0009703_decreased_birth_body0.42937507
103MP0003935_abnormal_craniofacial_develop0.41422624
104MP0002067_abnormal_sensory_capabilities0.39986276
105MP0002127_abnormal_cardiovascular_syste0.39499241
106MP0000566_synostosis0.39218267
107MP0004215_abnormal_myocardial_fiber0.38183338
108MP0004019_abnormal_vitamin_homeostasis0.38164805
109MP0009278_abnormal_bone_marrow0.37929711
110MP0001502_abnormal_circadian_rhythm0.37138666
111MP0001915_intracranial_hemorrhage0.36823890
112MP0002269_muscular_atrophy0.36631876
113MP0005384_cellular_phenotype0.36334670
114MP0002116_abnormal_craniofacial_bone0.36095011
115MP0003861_abnormal_nervous_system0.35856821
116MP0000537_abnormal_urethra_morphology0.34522519
117MP0006036_abnormal_mitochondrial_physio0.34163779
118MP0002092_abnormal_eye_morphology0.33079153
119MP0005621_abnormal_cell_physiology0.32734136
120MP0001727_abnormal_embryo_implantation0.32377395
121MP0000703_abnormal_thymus_morphology0.31421876
122MP0005391_vision/eye_phenotype0.28714453
123MP0001661_extended_life_span0.28622592
124MP0003119_abnormal_digestive_system0.27708332
125MP0005666_abnormal_adipose_tissue0.27358995
126MP0003941_abnormal_skin_development0.27174325
127MP0009697_abnormal_copulation0.26245182
128MP0004134_abnormal_chest_morphology0.26132249
129MP0003937_abnormal_limbs/digits/tail_de0.24953974
130MP0001919_abnormal_reproductive_system0.24682615
131MP0002970_abnormal_white_adipose0.21461837
132MP0005266_abnormal_metabolism0.20638436
133MP0006072_abnormal_retinal_apoptosis0.20572193
134MP0003943_abnormal_hepatobiliary_system0.20482416
135MP0003221_abnormal_cardiomyocyte_apopto0.19939830
136MP0002009_preneoplasia0.18319362
137MP0000432_abnormal_head_morphology0.17135966
138MP0003567_abnormal_fetal_cardiomyocyte0.16870912
139MP0002114_abnormal_axial_skeleton0.16728532
140MP0005395_other_phenotype0.16381029
141MP0004036_abnormal_muscle_relaxation0.16160572
142MP0005253_abnormal_eye_physiology0.16106646
143MP0002697_abnormal_eye_size0.15782682

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.62847500
2Absent/shortened dynein arms (HP:0200106)9.04558197
3Dynein arm defect of respiratory motile cilia (HP:0012255)9.04558197
4Azoospermia (HP:0000027)7.28673588
5Abnormal spermatogenesis (HP:0008669)7.09990098
6Abnormal respiratory motile cilium physiology (HP:0012261)6.56625252
7Abnormal respiratory epithelium morphology (HP:0012253)6.25726904
8Abnormal respiratory motile cilium morphology (HP:0005938)6.25726904
9Abnormality of the lower motor neuron (HP:0002366)6.01731447
10Rhinitis (HP:0012384)5.84910260
11Gonadotropin excess (HP:0000837)5.46049442
12Chronic bronchitis (HP:0004469)5.23118786
13Oligodactyly (hands) (HP:0001180)5.16169076
14Abnormal ciliary motility (HP:0012262)5.13420699
15Infertility (HP:0000789)5.11757276
16Volvulus (HP:0002580)5.11100696
17Nasal polyposis (HP:0100582)4.52153229
18Degeneration of the lateral corticospinal tracts (HP:0002314)4.46049979
19Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.46049979
20Amyotrophic lateral sclerosis (HP:0007354)4.05643622
21Osteomalacia (HP:0002749)3.88243534
22Nephronophthisis (HP:0000090)3.85461984
23Abnormality of the nasal mucosa (HP:0000433)3.63485028
24Bronchiectasis (HP:0002110)3.55180792
25Abnormality of the corticospinal tract (HP:0002492)3.49509920
2611 pairs of ribs (HP:0000878)3.48972931
27Upper motor neuron abnormality (HP:0002127)3.47128353
28Male infertility (HP:0003251)3.46788142
29Bronchitis (HP:0012387)3.44834395
30Horizontal nystagmus (HP:0000666)3.34554724
31Fibular hypoplasia (HP:0003038)3.29131657
32Impulsivity (HP:0100710)3.26712836
33Abnormality of the anterior horn cell (HP:0006802)3.14724137
34Degeneration of anterior horn cells (HP:0002398)3.14724137
35Rimmed vacuoles (HP:0003805)3.11916113
36Scotoma (HP:0000575)3.07670162
37Supernumerary spleens (HP:0009799)2.96236866
38Chromsome breakage (HP:0040012)2.92335426
39Abnormality of the renal medulla (HP:0100957)2.84995271
40Tubulointerstitial nephritis (HP:0001970)2.83431098
41Impaired vibration sensation in the lower limbs (HP:0002166)2.70722516
42Capillary hemangiomas (HP:0005306)2.69599862
43Lip pit (HP:0100267)2.69327989
44Chromosomal breakage induced by crosslinking agents (HP:0003221)2.69064620
45Selective tooth agenesis (HP:0001592)2.68218281
46Abnormality of DNA repair (HP:0003254)2.65824519
47Resting tremor (HP:0002322)2.64331776
48Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.64296197
49Severe visual impairment (HP:0001141)2.62264526
50Abnormality of chromosome segregation (HP:0002916)2.42670399
51Facial cleft (HP:0002006)2.41919871
52Atrophy/Degeneration involving motor neurons (HP:0007373)2.39166552
53Ectopic kidney (HP:0000086)2.33452894
54Abnormality of chromosome stability (HP:0003220)2.30244776
55Recurrent otitis media (HP:0000403)2.28500361
56Recurrent sinusitis (HP:0011108)2.28222409
57Wrist flexion contracture (HP:0001239)2.27829900
58Molar tooth sign on MRI (HP:0002419)2.27428152
59Abnormality of midbrain morphology (HP:0002418)2.27428152
60Aplasia/Hypoplasia of the earlobes (HP:0009906)2.27278507
61Recurrent bronchitis (HP:0002837)2.25978134
62Papillary thyroid carcinoma (HP:0002895)2.24926055
63Menstrual irregularities (HP:0000858)2.23516990
64Abnormality of the duodenum (HP:0002246)2.22369803
65Tubular atrophy (HP:0000092)2.21459712
66Heterotopia (HP:0002282)2.20378111
67Premature ovarian failure (HP:0008209)2.18918137
68Abdominal situs inversus (HP:0003363)2.18874079
69Abnormality of abdominal situs (HP:0011620)2.18874079
70Aplasia/Hypoplasia of the fibula (HP:0006492)2.13103599
71Spontaneous abortion (HP:0005268)2.12145252
72Shoulder girdle muscle weakness (HP:0003547)2.11962516
73Broad distal phalanx of finger (HP:0009836)2.10833981
74Impaired proprioception (HP:0010831)2.09143719
75Postaxial foot polydactyly (HP:0001830)2.07883827
76Short ribs (HP:0000773)2.06093429
77Hyperpituitarism (HP:0010514)2.05844406
78Anterior segment dysgenesis (HP:0007700)2.05406095
79Hyperkalemia (HP:0002153)2.04762980
80Aplasia/Hypoplasia of the sternum (HP:0006714)2.04634238
81Tubulointerstitial abnormality (HP:0001969)2.04407893
82Aplasia/Hypoplasia of the uvula (HP:0010293)2.03742371
83Nephroblastoma (Wilms tumor) (HP:0002667)2.03293910
84Meckel diverticulum (HP:0002245)2.02286770
85Bundle branch block (HP:0011710)2.01206571
86Microglossia (HP:0000171)1.97926138
87Breast carcinoma (HP:0003002)1.97525654
88Facial hemangioma (HP:0000329)1.95900675
89Non-midline cleft lip (HP:0100335)1.94949880
90Median cleft lip (HP:0000161)1.94389127
91Abnormality of the renal collecting system (HP:0004742)1.93355148
92Missing ribs (HP:0000921)1.92510133
93Medial flaring of the eyebrow (HP:0010747)1.89780804
94Abnormality of the preputium (HP:0100587)1.89606332
95Sloping forehead (HP:0000340)1.88799367
96Hypoplasia of the capital femoral epiphysis (HP:0003090)1.88528058
97Abnormality of the ileum (HP:0001549)1.88386461
98Absent thumb (HP:0009777)1.88020757
99Absent radius (HP:0003974)1.87445877
100Fair hair (HP:0002286)1.86109286
101Embryonal renal neoplasm (HP:0011794)1.85304624
102Bell-shaped thorax (HP:0001591)1.83028701
103Carpal bone hypoplasia (HP:0001498)1.82990658
104Stage 5 chronic kidney disease (HP:0003774)1.80481372
105Medulloblastoma (HP:0002885)1.79525614
106Hypergonadotropic hypogonadism (HP:0000815)1.78507437
107Abnormality of the phalanges of the hallux (HP:0010057)1.78072783
108Duplicated collecting system (HP:0000081)1.77362610
109Bony spicule pigmentary retinopathy (HP:0007737)1.76613939
110Small intestinal stenosis (HP:0012848)1.75686252
111Duodenal stenosis (HP:0100867)1.75686252
112Impaired vibratory sensation (HP:0002495)1.74701848
113Hand muscle atrophy (HP:0009130)1.73648507
114Absent forearm bone (HP:0003953)1.73425528
115Aplasia involving forearm bones (HP:0009822)1.73425528
116Oculomotor apraxia (HP:0000657)1.72773018
117Enlarged penis (HP:0000040)1.71187407
118Multicystic kidney dysplasia (HP:0000003)1.70230882
119Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.68144979
120Short tibia (HP:0005736)1.67790574
121Abnormality of the labia (HP:0000058)1.66654398
122Abnormality of lateral ventricle (HP:0030047)1.66296233
123Peripheral hypomyelination (HP:0007182)1.66065487
124Ependymoma (HP:0002888)1.65327413
125Astigmatism (HP:0000483)1.63450816
126Truncal obesity (HP:0001956)1.63350230
127Duplication of thumb phalanx (HP:0009942)1.63285897
128Abnormal lung lobation (HP:0002101)1.62800008
129Limb-girdle muscle weakness (HP:0003325)1.62528824
130Conjunctival telangiectasia (HP:0000524)1.61703687
131Male pseudohermaphroditism (HP:0000037)1.56981686
132Aplasia/Hypoplasia of the tibia (HP:0005772)1.55753459
133Abnormality of the carotid arteries (HP:0005344)1.54614653
134Sandal gap (HP:0001852)1.54352593
135Absent frontal sinuses (HP:0002688)1.52474544
136Short thorax (HP:0010306)1.51562252
137Hypoplasia of the radius (HP:0002984)1.50482378
138Renal dysplasia (HP:0000110)1.49268397
139Rhabdomyosarcoma (HP:0002859)1.47224253
140Prominent nose (HP:0000448)1.46529821
141Congenital hepatic fibrosis (HP:0002612)1.45637528
142Abnormality of ocular smooth pursuit (HP:0000617)1.45432622
143Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.43338183
144Increased nuchal translucency (HP:0010880)1.43112076
145Dislocated radial head (HP:0003083)1.40949921
146Oligodactyly (HP:0012165)1.40397422
147Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.38875530
148Absent epiphyses (HP:0010577)1.38875530
149Postaxial hand polydactyly (HP:0001162)1.37688829
150Abnormality of the labia minora (HP:0012880)1.37107476

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.40193316
2PDK47.40193316
3CDK195.83569108
4PDK24.61568195
5CDC74.45729535
6ACVR1B4.30980692
7MET3.13156138
8PRKD32.93587198
9WEE12.81875375
10TESK12.81039566
11NEK22.75753323
12CDK122.74683645
13MAP3K92.49342257
14MAP3K132.30055879
15ICK2.19438792
16OXSR11.98533582
17ARAF1.95912553
18NEK91.94398062
19TTK1.82551715
20PNCK1.81954348
21NEK61.75093456
22KSR21.71366167
23MST1R1.69740034
24BRSK21.59743581
25PTK2B1.59275393
26PLK41.56949111
27PLK11.48031983
28ATR1.46654139
29CHEK11.33791385
30WNK41.25761559
31CCNB11.18280463
32BUB11.13745870
33MUSK1.11458576
34PASK1.10318435
35CHEK21.09602627
36DYRK31.04662406
37STK31.03629340
38ATM1.03540431
39KSR11.00771609
40TYRO30.99102348
41STK390.98791820
42ZAK0.98537214
43BRD40.97469594
44NTRK30.96973956
45AKT30.91745314
46PBK0.91157599
47RAF10.90647673
48BRSK10.90508296
49MAP3K20.87912282
50NEK10.85952665
51MAP3K40.85159073
52PRKCI0.84239258
53CDK70.82838037
54STK38L0.81568373
55MOS0.80878047
56PDPK10.74594708
57FLT30.73880658
58INSRR0.71710024
59WNK10.69134325
60BMPR1B0.67190190
61SRPK10.64117424
62CDK40.62843812
63AURKB0.60668107
64EIF2AK10.59848560
65CDK30.59025039
66CDK20.57723681
67PLK30.57047843
68TGFBR10.56427843
69SGK10.55942037
70STK380.55873540
71MELK0.54763488
72CDK10.52942053
73STK40.45826727
74BMX0.45691565
75RET0.45642506
76MTOR0.45243611
77MKNK20.44993717
78PRKG10.44960581
79EGFR0.43099736
80DYRK1B0.42550211
81PDGFRB0.41903902
82DDR20.41775826
83PIK3CG0.41769190
84CSF1R0.40546264
85FGR0.40278564
86IRAK10.39903612
87EEF2K0.39174860
88CDK11A0.38995056
89PDK10.38741322
90SCYL20.37989859
91AURKA0.37695351
92WNK30.36094754
93PINK10.36085365
94MARK30.35669146
95PRKDC0.34589326
96PTK20.34016023
97MAP3K50.32765524
98MAP3K60.32487829
99PLK20.31479063
100DYRK1A0.30759346
101CDK90.30506839
102CAMK10.30099631
103STK160.29973471
104PAK40.29777259
105CSNK2A20.28872526
106RPS6KA10.28276094
107PRKCZ0.28042449
108MKNK10.27894564
109MAPK130.27873601
110CLK10.26855719
111PAK10.26255214
112LATS10.26204605
113MAP3K80.26016146
114MAP2K20.25929159
115MAP4K20.25812555
116GSK3B0.25686673
117CSNK2A10.24894874
118CSNK1D0.23994584
119RPS6KB10.23655435
120MAPK150.23434732
121CDK80.22361929
122STK100.21382589
123MAPK80.19191457
124EIF2AK30.17664104
125STK240.17005329
126KIT0.16416731
127MAPK140.14640017
128TSSK60.14595031
129CDC42BPA0.14179316
130CSNK1E0.12940722
131BRAF0.12180181
132LMTK20.11790964
133CAMK1G0.10921214
134PRKAA10.09867457
135IRAK20.09117249
136VRK10.08736147
137MAPK100.08679388
138MAPK10.07658946
139PRKACB0.06087433
140AKT10.05469101
141CDK60.05457935
142MAP2K70.05060353
143MAP2K60.04999885

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030224.68930389
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.37864876
3DNA replication_Homo sapiens_hsa030303.67450857
4Homologous recombination_Homo sapiens_hsa034403.66232600
5Fanconi anemia pathway_Homo sapiens_hsa034603.64463634
6Mismatch repair_Homo sapiens_hsa034303.49839877
7RNA transport_Homo sapiens_hsa030133.40446470
8mRNA surveillance pathway_Homo sapiens_hsa030153.00630319
9Cell cycle_Homo sapiens_hsa041102.81789523
10Spliceosome_Homo sapiens_hsa030402.52986103
11Nucleotide excision repair_Homo sapiens_hsa034202.51850203
12Selenocompound metabolism_Homo sapiens_hsa004502.50175667
13Non-homologous end-joining_Homo sapiens_hsa034502.47872621
14Oocyte meiosis_Homo sapiens_hsa041142.39575329
15Dorso-ventral axis formation_Homo sapiens_hsa043202.31499849
16Proteasome_Homo sapiens_hsa030502.23227609
17Base excision repair_Homo sapiens_hsa034102.11511044
18RNA degradation_Homo sapiens_hsa030182.08671947
19Pyruvate metabolism_Homo sapiens_hsa006202.04962835
20Vitamin B6 metabolism_Homo sapiens_hsa007501.97389255
21Sulfur relay system_Homo sapiens_hsa041221.95251350
22Regulation of autophagy_Homo sapiens_hsa041401.93976221
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.82116120
24RNA polymerase_Homo sapiens_hsa030201.72787880
25Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.72616977
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.61858201
27Circadian rhythm_Homo sapiens_hsa047101.53649023
28Olfactory transduction_Homo sapiens_hsa047401.51925121
29Pyrimidine metabolism_Homo sapiens_hsa002401.51384188
30Pentose phosphate pathway_Homo sapiens_hsa000301.35621901
31Purine metabolism_Homo sapiens_hsa002301.34049785
32Linoleic acid metabolism_Homo sapiens_hsa005911.23097638
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.21913865
34Huntingtons disease_Homo sapiens_hsa050161.20140806
35Glucagon signaling pathway_Homo sapiens_hsa049221.18412379
36One carbon pool by folate_Homo sapiens_hsa006701.15536507
37Fatty acid biosynthesis_Homo sapiens_hsa000611.15385686
38p53 signaling pathway_Homo sapiens_hsa041151.14269360
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.14106859
40Propanoate metabolism_Homo sapiens_hsa006401.13845006
41Herpes simplex infection_Homo sapiens_hsa051681.13439905
42Antigen processing and presentation_Homo sapiens_hsa046121.13223150
43Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.07402635
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.05293893
45Glycerolipid metabolism_Homo sapiens_hsa005611.04882102
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.03094068
47Epstein-Barr virus infection_Homo sapiens_hsa051691.01768715
48mTOR signaling pathway_Homo sapiens_hsa041500.99357574
49Folate biosynthesis_Homo sapiens_hsa007900.92455480
50beta-Alanine metabolism_Homo sapiens_hsa004100.83824976
51Caffeine metabolism_Homo sapiens_hsa002320.74025593
52Ovarian steroidogenesis_Homo sapiens_hsa049130.71335317
53Influenza A_Homo sapiens_hsa051640.70781885
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.68993608
55HTLV-I infection_Homo sapiens_hsa051660.68276963
56Viral carcinogenesis_Homo sapiens_hsa052030.64519292
57Biosynthesis of amino acids_Homo sapiens_hsa012300.64236857
58Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63886640
59Phototransduction_Homo sapiens_hsa047440.59119441
60Carbon metabolism_Homo sapiens_hsa012000.56951287
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56623445
62Calcium signaling pathway_Homo sapiens_hsa040200.56337032
63Glycerophospholipid metabolism_Homo sapiens_hsa005640.54554991
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52572726
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.52389639
66Lysine degradation_Homo sapiens_hsa003100.51830425
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51504219
68Phenylalanine metabolism_Homo sapiens_hsa003600.51465317
69Nicotine addiction_Homo sapiens_hsa050330.49374148
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49276819
71Fatty acid elongation_Homo sapiens_hsa000620.49062901
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.48289979
73ErbB signaling pathway_Homo sapiens_hsa040120.45877991
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45231009
75Taste transduction_Homo sapiens_hsa047420.44645607
76Legionellosis_Homo sapiens_hsa051340.44337563
77Type II diabetes mellitus_Homo sapiens_hsa049300.43473042
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.41897687
79Thyroid cancer_Homo sapiens_hsa052160.40877878
80Retinol metabolism_Homo sapiens_hsa008300.40568291
81Choline metabolism in cancer_Homo sapiens_hsa052310.39705275
82Ether lipid metabolism_Homo sapiens_hsa005650.39497203
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.39312182
84Systemic lupus erythematosus_Homo sapiens_hsa053220.38379260
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35808808
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35655743
87Glutathione metabolism_Homo sapiens_hsa004800.34799533
88TGF-beta signaling pathway_Homo sapiens_hsa043500.33968693
89Fat digestion and absorption_Homo sapiens_hsa049750.33186570
90Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.32673124
91Gap junction_Homo sapiens_hsa045400.32500908
92Synaptic vesicle cycle_Homo sapiens_hsa047210.30861805
93Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.28217525
94Endocytosis_Homo sapiens_hsa041440.27455666
95Fatty acid degradation_Homo sapiens_hsa000710.26776550
96Protein digestion and absorption_Homo sapiens_hsa049740.25817080
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.24373804
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23044131
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.22746759
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22691233
101MAPK signaling pathway_Homo sapiens_hsa040100.21459648
102Amphetamine addiction_Homo sapiens_hsa050310.20476891
103Hedgehog signaling pathway_Homo sapiens_hsa043400.19327395
104Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.19157212
105Butanoate metabolism_Homo sapiens_hsa006500.18530122
106FoxO signaling pathway_Homo sapiens_hsa040680.17826463
107N-Glycan biosynthesis_Homo sapiens_hsa005100.17081119
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.15037630
109PPAR signaling pathway_Homo sapiens_hsa033200.15015095
110Prostate cancer_Homo sapiens_hsa052150.14922833
111Long-term potentiation_Homo sapiens_hsa047200.14295058
112cGMP-PKG signaling pathway_Homo sapiens_hsa040220.14223578
113Small cell lung cancer_Homo sapiens_hsa052220.13905092
114Arginine and proline metabolism_Homo sapiens_hsa003300.13478642
115Long-term depression_Homo sapiens_hsa047300.12872725
116Drug metabolism - other enzymes_Homo sapiens_hsa009830.12542283
117Wnt signaling pathway_Homo sapiens_hsa043100.12426321
118VEGF signaling pathway_Homo sapiens_hsa043700.11587641
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.10965278
120Mineral absorption_Homo sapiens_hsa049780.10592605
121Fructose and mannose metabolism_Homo sapiens_hsa000510.10202231
122Tight junction_Homo sapiens_hsa045300.09642612
123Metabolic pathways_Homo sapiens_hsa011000.09293488
124Hippo signaling pathway_Homo sapiens_hsa043900.08932157
125ABC transporters_Homo sapiens_hsa020100.08423549
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.08185910
127Alcoholism_Homo sapiens_hsa050340.07902879
128Notch signaling pathway_Homo sapiens_hsa043300.07352408
129HIF-1 signaling pathway_Homo sapiens_hsa040660.07016604
130Endometrial cancer_Homo sapiens_hsa052130.06936480
131AMPK signaling pathway_Homo sapiens_hsa041520.06698479
132Fatty acid metabolism_Homo sapiens_hsa012120.06587683
133Inositol phosphate metabolism_Homo sapiens_hsa005620.06414799
134Estrogen signaling pathway_Homo sapiens_hsa049150.06212363
135Arachidonic acid metabolism_Homo sapiens_hsa005900.05538304
136Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.05481829
137Basal cell carcinoma_Homo sapiens_hsa052170.05333714
138MicroRNAs in cancer_Homo sapiens_hsa052060.05321607
139Phosphatidylinositol signaling system_Homo sapiens_hsa040700.04645877
140Adherens junction_Homo sapiens_hsa045200.04392825
141Serotonergic synapse_Homo sapiens_hsa047260.04278224
142Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.03704377
143Toxoplasmosis_Homo sapiens_hsa051450.02965319
144Cardiac muscle contraction_Homo sapiens_hsa042600.01898042
145Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964-0.0201929
146Renin secretion_Homo sapiens_hsa04924-0.0064568

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