DDX41

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a member of the DEAD box protein family and interacts with several spliceosomal proteins. In addition, the encoded protein may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peptidyl-arginine omega-N-methylation (GO:0035247)4.72483656
2ribosomal small subunit assembly (GO:0000028)4.60548663
3DNA deamination (GO:0045006)4.54004879
4protein maturation by protein folding (GO:0022417)4.48624697
5DNA strand elongation involved in DNA replication (GO:0006271)4.45608811
6formation of translation preinitiation complex (GO:0001731)4.42383230
7nucleobase biosynthetic process (GO:0046112)4.37628380
8DNA strand elongation (GO:0022616)4.27256181
9telomere maintenance via semi-conservative replication (GO:0032201)4.22833501
10folic acid-containing compound biosynthetic process (GO:0009396)4.19684788
11purine nucleobase biosynthetic process (GO:0009113)4.16587286
12spliceosomal tri-snRNP complex assembly (GO:0000244)4.16060354
13DNA replication initiation (GO:0006270)4.08287462
14DNA unwinding involved in DNA replication (GO:0006268)4.02106691
15IMP biosynthetic process (GO:0006188)4.00006067
16pentose-phosphate shunt (GO:0006098)3.99750806
17negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.97811004
18glucose 6-phosphate metabolic process (GO:0051156)3.89494056
19peptidyl-arginine methylation (GO:0018216)3.88472427
20peptidyl-arginine N-methylation (GO:0035246)3.88472427
21histone arginine methylation (GO:0034969)3.88415924
22maturation of SSU-rRNA (GO:0030490)3.83102800
23regulation of translational fidelity (GO:0006450)3.80363009
24telomere maintenance via recombination (GO:0000722)3.73036989
25protein retention in ER lumen (GO:0006621)3.71187352
26IMP metabolic process (GO:0046040)3.67147130
27glucose catabolic process (GO:0006007)3.64347682
28protein localization to kinetochore (GO:0034501)3.61267088
29maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.58224587
30ribosome biogenesis (GO:0042254)3.57904851
31proline biosynthetic process (GO:0006561)3.55018798
32DNA replication checkpoint (GO:0000076)3.52559671
33retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.47110900
34mitotic nuclear envelope disassembly (GO:0007077)3.45005395
35regulation of mammary gland epithelial cell proliferation (GO:0033599)3.44054039
36NADPH regeneration (GO:0006740)3.43547023
37mitotic recombination (GO:0006312)3.43179238
38establishment of viral latency (GO:0019043)3.42770601
39mitotic nuclear envelope reassembly (GO:0007084)3.36052225
40nuclear envelope reassembly (GO:0031468)3.36052225
41Golgi transport vesicle coating (GO:0048200)3.33442846
42COPI coating of Golgi vesicle (GO:0048205)3.33442846
43establishment of integrated proviral latency (GO:0075713)3.30680934
44pinocytosis (GO:0006907)3.26104860
45pentose metabolic process (GO:0019321)3.25764901
46GDP-mannose metabolic process (GO:0019673)3.24749791
47ribonucleoprotein complex biogenesis (GO:0022613)3.24308770
48viral transcription (GO:0019083)3.22053470
49telomere maintenance via telomere lengthening (GO:0010833)3.21956276
50UV protection (GO:0009650)3.21303424
51glycolytic process (GO:0006096)3.18885678
52translational termination (GO:0006415)3.18809634
53DNA replication-dependent nucleosome organization (GO:0034723)3.18492602
54DNA replication-dependent nucleosome assembly (GO:0006335)3.18492602
55negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.14803706
56mitotic metaphase plate congression (GO:0007080)3.13885454
57membrane disassembly (GO:0030397)3.13883140
58nuclear envelope disassembly (GO:0051081)3.13883140
59lipopolysaccharide biosynthetic process (GO:0009103)3.12633216
60SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.11731773
61nucleotide-excision repair, DNA gap filling (GO:0006297)3.11628690
62somatic diversification of immune receptors via somatic mutation (GO:0002566)3.10222801
63somatic hypermutation of immunoglobulin genes (GO:0016446)3.10222801
64translational elongation (GO:0006414)3.08751359
65ribosomal large subunit biogenesis (GO:0042273)3.06473629
66negative regulation of cell size (GO:0045792)3.06432201
67translational initiation (GO:0006413)3.06384953
68nucleotide salvage (GO:0043173)3.05962907
69nuclear pore organization (GO:0006999)3.05626419
70negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.05527186
71protein localization to chromosome, centromeric region (GO:0071459)3.04215103
72ribosome assembly (GO:0042255)3.03419299
73nucleobase-containing small molecule interconversion (GO:0015949)2.99772821
74deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.99761139
75protein targeting to ER (GO:0045047)2.99067264
76cotranslational protein targeting to membrane (GO:0006613)2.98997677
77proteasome assembly (GO:0043248)2.95736336
78rRNA modification (GO:0000154)2.95409266
79modulation by virus of host process (GO:0019054)2.93246239
80pteridine-containing compound biosynthetic process (GO:0042559)2.92626828
81pseudouridine synthesis (GO:0001522)2.92387029
82viral mRNA export from host cell nucleus (GO:0046784)2.92271536
83rRNA processing (GO:0006364)2.91110865
84mitotic chromosome condensation (GO:0007076)2.90385195
85negative regulation of RNA splicing (GO:0033119)2.90356043
86transcription-coupled nucleotide-excision repair (GO:0006283)2.88534380
87spliceosomal snRNP assembly (GO:0000387)2.87021887
88attachment of spindle microtubules to kinetochore (GO:0008608)2.86051149
89negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.85154920
90protein localization to endoplasmic reticulum (GO:0070972)2.84792226
91negative regulation of erythrocyte differentiation (GO:0045647)2.84777492
92positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.84764660
93nucleosome disassembly (GO:0006337)2.83180993
94protein-DNA complex disassembly (GO:0032986)2.83180993
95L-serine metabolic process (GO:0006563)2.83077918
96telomere organization (GO:0032200)2.82482990
97ribosomal small subunit biogenesis (GO:0042274)2.82427056
98telomere maintenance (GO:0000723)2.82378963
99rRNA metabolic process (GO:0016072)2.81782589
100establishment of protein localization to endoplasmic reticulum (GO:0072599)2.81636452
101negative regulation of DNA-templated transcription, elongation (GO:0032785)2.81517897
102anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.80398428
103regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.79413421
104regulation of mitochondrial translation (GO:0070129)2.79256161
105protein insertion into membrane (GO:0051205)2.79031515
106chromatin remodeling at centromere (GO:0031055)2.78976335
107NADH metabolic process (GO:0006734)2.78750312
108CENP-A containing nucleosome assembly (GO:0034080)2.78702569
109snRNA metabolic process (GO:0016073)2.78698261
110regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.77426545
111nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.77001359
112folic acid metabolic process (GO:0046655)2.76622407
113maternal placenta development (GO:0001893)2.75544515
114DNA replication-independent nucleosome assembly (GO:0006336)2.75389258
115DNA replication-independent nucleosome organization (GO:0034724)2.75389258
116establishment of chromosome localization (GO:0051303)2.75259789
117metaphase plate congression (GO:0051310)2.74989213
118DNA duplex unwinding (GO:0032508)2.74751751
119endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.74134711
120DNA geometric change (GO:0032392)2.73834241
121positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.73800997
122termination of RNA polymerase II transcription (GO:0006369)2.73081755
123modulation by symbiont of host cellular process (GO:0044068)2.72203513
124mitochondrial fusion (GO:0008053)2.71058799
125* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.70972484
126* mRNA splicing, via spliceosome (GO:0000398)2.70972484
127* RNA splicing, via transesterification reactions (GO:0000375)2.69503129
128regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.68978949
129regulation of nuclear cell cycle DNA replication (GO:0033262)2.68661260
130regulation of spindle organization (GO:0090224)2.68648379
131pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.67679118
132lipopolysaccharide metabolic process (GO:0008653)2.67622754
133guanosine-containing compound biosynthetic process (GO:1901070)2.67269926
134transcription elongation from RNA polymerase III promoter (GO:0006385)2.66338896
135termination of RNA polymerase III transcription (GO:0006386)2.66338896
136regulation of release of cytochrome c from mitochondria (GO:0090199)2.66061403
137translation (GO:0006412)2.65099699
138GMP metabolic process (GO:0046037)2.64043743
139pyrimidine-containing compound salvage (GO:0008655)2.63514350
140pyrimidine nucleoside salvage (GO:0043097)2.63514350
141positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.63346029
142base-excision repair (GO:0006284)2.63031779
143pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.62714788
144negative regulation of mRNA metabolic process (GO:1903312)2.62589821
145tRNA methylation (GO:0030488)2.60990262
146cell cycle G1/S phase transition (GO:0044843)2.60941786
147G1/S transition of mitotic cell cycle (GO:0000082)2.60941786
148postreplication repair (GO:0006301)2.59900173
149negative regulation of ligase activity (GO:0051352)2.59234090
150negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.59234090
151nuclear pore complex assembly (GO:0051292)2.58754308
152response to peptidoglycan (GO:0032494)2.58586499
153activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.58087328
154monosaccharide biosynthetic process (GO:0046364)2.57923608
1553-UTR-mediated mRNA stabilization (GO:0070935)2.57762494
156apoptotic process involved in morphogenesis (GO:0060561)2.57136405
157barbed-end actin filament capping (GO:0051016)2.57055291
158rRNA transcription (GO:0009303)2.56703602
159pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.56054076
160protein localization to endosome (GO:0036010)2.55983027
161translesion synthesis (GO:0019985)2.55605643
162positive regulation of nuclease activity (GO:0032075)2.54706869
163viral life cycle (GO:0019058)2.54369901
164negative regulation of B cell apoptotic process (GO:0002903)2.54114549
165regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.53104550
166DNA-templated transcription, termination (GO:0006353)2.52425148
167negative regulation of mRNA processing (GO:0050686)2.50517291
168mitotic sister chromatid segregation (GO:0000070)2.50337754
169pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.45323046
170intracellular estrogen receptor signaling pathway (GO:0030520)2.44851635
171snRNA processing (GO:0016180)2.44482453
172proline metabolic process (GO:0006560)2.43036901
173tricarboxylic acid metabolic process (GO:0072350)2.42253533
174positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.41821706
175Arp2/3 complex-mediated actin nucleation (GO:0034314)2.41621635
176protein export from nucleus (GO:0006611)2.41131242
177NIK/NF-kappaB signaling (GO:0038061)2.40343309
178tRNA aminoacylation for protein translation (GO:0006418)2.39859712
179cellular response to interleukin-4 (GO:0071353)2.39540107
180gluconeogenesis (GO:0006094)2.38329354
181positive regulation of mitochondrion organization (GO:0010822)2.37513122

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.19040199
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.77492151
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.73462695
4FOXM1_23109430_ChIP-Seq_U2OS_Human2.96025275
5E2F4_17652178_ChIP-ChIP_JURKAT_Human2.85257494
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.69081195
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.65901293
8* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.62864635
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.58857071
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.58759353
11* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.58230891
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.57666936
13* ETS1_20019798_ChIP-Seq_JURKAT_Human2.56766816
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.50515253
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.49709864
16MYC_22102868_ChIP-Seq_BL_Human2.26895439
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.26357394
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.23521169
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.13501839
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.11476872
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.11292885
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.10390187
23* XRN2_22483619_ChIP-Seq_HELA_Human2.09528009
24LXR_22292898_ChIP-Seq_THP-1_Human2.07802981
25* VDR_23849224_ChIP-Seq_CD4+_Human2.06544971
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.92787669
27ELK3_25401928_ChIP-Seq_HUVEC_Human1.89841078
28* FOXP3_21729870_ChIP-Seq_TREG_Human1.88621047
29* CIITA_25753668_ChIP-Seq_RAJI_Human1.87548284
30GABP_19822575_ChIP-Seq_HepG2_Human1.85461817
31* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.85391046
32* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.84978115
33PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.84623386
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.75286425
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72879629
36DCP1A_22483619_ChIP-Seq_HELA_Human1.72628556
37ZNF263_19887448_ChIP-Seq_K562_Human1.72306799
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.69628286
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.67957579
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.67557450
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.66476316
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.64717464
43RACK7_27058665_Chip-Seq_MCF-7_Human1.62348127
44* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.60309549
45NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59542004
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.59523639
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.59200706
48KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.58822651
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57383196
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.55452225
51* TET1_21451524_ChIP-Seq_MESCs_Mouse1.52319159
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.51058882
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.50236223
54VDR_21846776_ChIP-Seq_THP-1_Human1.50224127
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49912107
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.48231908
57TTF2_22483619_ChIP-Seq_HELA_Human1.47613152
58P68_20966046_ChIP-Seq_HELA_Human1.47299384
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46609356
60SRY_22984422_ChIP-ChIP_TESTIS_Rat1.46293793
61KDM5A_27292631_Chip-Seq_BREAST_Human1.43633519
62ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.43412320
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.43293275
64* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.43217047
65ELF1_20517297_ChIP-Seq_JURKAT_Human1.40188381
66IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.38974690
67AR_21909140_ChIP-Seq_LNCAP_Human1.37516704
68HIF1A_21447827_ChIP-Seq_MCF-7_Human1.36829096
69* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36531399
70GATA1_22025678_ChIP-Seq_K562_Human1.34069178
71TFEB_21752829_ChIP-Seq_HELA_Human1.32944069
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.32826408
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32175295
74KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30512274
75SPI1_23547873_ChIP-Seq_NB4_Human1.30088787
76RARG_19884340_ChIP-ChIP_MEFs_Mouse1.29248246
77SRF_21415370_ChIP-Seq_HL-1_Mouse1.28963250
78SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.28267519
79ELK1_19687146_ChIP-ChIP_HELA_Human1.27912594
80KDM2B_26808549_Chip-Seq_DND41_Human1.26699249
81CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.25716184
82IRF8_22096565_ChIP-ChIP_GC-B_Human1.22762709
83SA1_27219007_Chip-Seq_ERYTHROID_Human1.21788645
84CTCF_27219007_Chip-Seq_ERYTHROID_Human1.21212824
85STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21134602
86TCF7_22412390_ChIP-Seq_EML_Mouse1.20324573
87KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.18521046
88CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18392489
89MAF_26560356_Chip-Seq_TH2_Human1.17220914
90TP63_17297297_ChIP-ChIP_HaCaT_Human1.14146847
91ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13660545
92NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13251945
93MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.13102803
94BCL6_27268052_Chip-Seq_Bcells_Human1.12553685
95NCOR1_26117541_ChIP-Seq_K562_Human1.12168585
96RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.11843007
97GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.11828683
98POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.11480659
99BCOR_27268052_Chip-Seq_Bcells_Human1.10810767
100TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10723428
101E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.09608144
102SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09561440
103NOTCH1_21737748_ChIP-Seq_TLL_Human1.08691831
104CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08457503
105* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08004672
106SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.07604708
107HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07352670
108* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.06120337
109DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05508964
110* FOXP1_21924763_ChIP-Seq_HESCs_Human1.05444342
111NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.05403897
112E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05025558
113VDR_24763502_ChIP-Seq_THP-1_Human1.04721953
114UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04679342
115RARB_24833708_ChIP-Seq_LIVER_Mouse1.02589533
116* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01915079
117BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00964716
118SMC4_20622854_ChIP-Seq_HELA_Human1.00582628
119ATF3_27146783_Chip-Seq_COLON_Human1.00288210
120DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98446006
121PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96523764
122CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96295963
123CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95799633
124MYB_21317192_ChIP-Seq_ERMYB_Mouse0.94959586
125POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94041670
126MAF_26560356_Chip-Seq_TH1_Human0.93768537
127MYB_26560356_Chip-Seq_TH1_Human0.93417656
128CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92549602
129UTX_26944678_Chip-Seq_JUKART_Human0.92358122
130IRF8_21731497_ChIP-ChIP_J774_Mouse0.92018161
131TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.90338627
132GATA1_22383799_ChIP-Seq_G1ME_Mouse0.89673481
133KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88983943
134SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88793801
135CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.87545084
136MYB_26560356_Chip-Seq_TH2_Human0.86291593
137MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.85768334
138RUNX1_22412390_ChIP-Seq_EML_Mouse0.83874876

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.93731982
2MP0008260_abnormal_autophagy3.75963732
3MP0004957_abnormal_blastocyst_morpholog3.72294282
4MP0010094_abnormal_chromosome_stability3.65219713
5MP0003111_abnormal_nucleus_morphology3.39610456
6MP0003077_abnormal_cell_cycle3.21207447
7MP0008058_abnormal_DNA_repair2.96597912
8MP0008007_abnormal_cellular_replicative2.90086164
9MP0002396_abnormal_hematopoietic_system2.76372940
10MP0005451_abnormal_body_composition2.66983504
11MP0003705_abnormal_hypodermis_morpholog2.61043205
12MP0008057_abnormal_DNA_replication2.57964743
13MP0003763_abnormal_thymus_physiology2.03757444
14MP0001730_embryonic_growth_arrest2.03419603
15MP0010352_gastrointestinal_tract_polyps1.99745691
16MP0004808_abnormal_hematopoietic_stem1.98635981
17MP0004233_abnormal_muscle_weight1.87816633
18MP0010307_abnormal_tumor_latency1.86789933
19MP0000490_abnormal_crypts_of1.85131555
20MP0003329_amyloid_beta_deposits1.84072020
21MP0001835_abnormal_antigen_presentation1.83936236
22MP0005058_abnormal_lysosome_morphology1.80286730
23MP0003303_peritoneal_inflammation1.75917692
24MP0008932_abnormal_embryonic_tissue1.74878444
25MP0009333_abnormal_splenocyte_physiolog1.74067803
26MP0002398_abnormal_bone_marrow1.73976432
27MP0000350_abnormal_cell_proliferation1.73330583
28MP0005501_abnormal_skin_physiology1.71172674
29MP0003123_paternal_imprinting1.68350166
30MP0004185_abnormal_adipocyte_glucose1.64292071
31MP0000689_abnormal_spleen_morphology1.62163724
32MP0000003_abnormal_adipose_tissue1.57731869
33MP0002019_abnormal_tumor_incidence1.55421651
34MP0001800_abnormal_humoral_immune1.55280887
35MP0003806_abnormal_nucleotide_metabolis1.55178760
36MP0002722_abnormal_immune_system1.54372707
37MP0005671_abnormal_response_to1.52176938
38MP0006035_abnormal_mitochondrial_morpho1.44992828
39MP0000703_abnormal_thymus_morphology1.44468821
40MP0001545_abnormal_hematopoietic_system1.44294188
41MP0005397_hematopoietic_system_phenotyp1.44294188
42MP0003786_premature_aging1.43644570
43MP0000313_abnormal_cell_death1.43595772
44MP0000604_amyloidosis1.42622881
45MP0002429_abnormal_blood_cell1.41970945
46MP0000685_abnormal_immune_system1.40706606
47MP0000716_abnormal_immune_system1.38739285
48MP0008877_abnormal_DNA_methylation1.38019637
49MP0002080_prenatal_lethality1.36817337
50MP0001697_abnormal_embryo_size1.36393929
51MP0002452_abnormal_antigen_presenting1.35875697
52MP0009840_abnormal_foam_cell1.35615227
53MP0002420_abnormal_adaptive_immunity1.31765072
54MP0000750_abnormal_muscle_regeneration1.30626713
55MP0005380_embryogenesis_phenotype1.29795895
56MP0001672_abnormal_embryogenesis/_devel1.29795895
57MP0001819_abnormal_immune_cell1.29355718
58MP0003453_abnormal_keratinocyte_physiol1.27539524
59MP0005083_abnormal_biliary_tract1.27518141
60MP0005375_adipose_tissue_phenotype1.25816042
61MP0002723_abnormal_immune_serum1.24068262
62MP0003436_decreased_susceptibility_to1.22561611
63MP0005666_abnormal_adipose_tissue1.22236792
64MP0003984_embryonic_growth_retardation1.20286088
65MP0006054_spinal_hemorrhage1.20217263
66MP0003283_abnormal_digestive_organ1.19342413
67MP0002089_abnormal_postnatal_growth/wei1.19175190
68MP0002405_respiratory_system_inflammati1.18733068
69MP0003186_abnormal_redox_activity1.17218238
70MP0002088_abnormal_embryonic_growth/wei1.16396236
71MP0004858_abnormal_nervous_system1.16178307
72MP0003075_altered_response_to1.14469988
73MP0004264_abnormal_extraembryonic_tissu1.14092580
74MP0003172_abnormal_lysosome_physiology1.12545141
75MP0002086_abnormal_extraembryonic_tissu1.11744961
76MP0002796_impaired_skin_barrier1.09591171
77MP0005464_abnormal_platelet_physiology1.09573370
78MP0005000_abnormal_immune_tolerance1.06256844
79MP0010234_abnormal_vibrissa_follicle1.04388471
80MP0000858_altered_metastatic_potential1.02663241
81MP0009785_altered_susceptibility_to1.02578374
82MP0000358_abnormal_cell_content/1.02558622
83MP0005387_immune_system_phenotype1.02509001
84MP0001790_abnormal_immune_system1.02509001
85MP0002060_abnormal_skin_morphology1.02298908
86MP0005025_abnormal_response_to1.00374184
87MP0001853_heart_inflammation1.00323067
88MP0002085_abnormal_embryonic_tissue0.99962472
89MP0004947_skin_inflammation0.99784351
90MP0001849_ear_inflammation0.99610654
91MP0010155_abnormal_intestine_physiology0.98016027
92MP0009931_abnormal_skin_appearance0.97929606
93MP0000465_gastrointestinal_hemorrhage0.97244148
94MP0000678_abnormal_parathyroid_gland0.95628196
95MP0002084_abnormal_developmental_patter0.95224744
96MP0000015_abnormal_ear_pigmentation0.94962363
97MP0002877_abnormal_melanocyte_morpholog0.94303138
98MP0005076_abnormal_cell_differentiation0.91107361
99MP0003943_abnormal_hepatobiliary_system0.90801879
100MP0001845_abnormal_inflammatory_respons0.90681011
101MP0004197_abnormal_fetal_growth/weight/0.90672429
102MP0000747_muscle_weakness0.90309009
103MP0002970_abnormal_white_adipose0.89625419
104MP0001764_abnormal_homeostasis0.89136681
105MP0000598_abnormal_liver_morphology0.88713775
106MP0002148_abnormal_hypersensitivity_rea0.87424086
107MP0009278_abnormal_bone_marrow0.87381888
108MP0009672_abnormal_birth_weight0.86749956
109MP0002419_abnormal_innate_immunity0.86709760
110MP0005257_abnormal_intraocular_pressure0.86539366
111MP0001727_abnormal_embryo_implantation0.85762166
112MP0001873_stomach_inflammation0.85607206
113MP0005023_abnormal_wound_healing0.85370690
114MP0002166_altered_tumor_susceptibility0.85329013
115MP0003566_abnormal_cell_adhesion0.84390288
116MP0000371_diluted_coat_color0.84253615
117MP0001216_abnormal_epidermal_layer0.82682797
118MP0005220_abnormal_exocrine_pancreas0.82613186
119MP0003221_abnormal_cardiomyocyte_apopto0.81048037
120MP0001915_intracranial_hemorrhage0.80864991
121MP0000537_abnormal_urethra_morphology0.79584073
122MP0003718_maternal_effect0.78977133
123MP0005384_cellular_phenotype0.78517226
124MP0000477_abnormal_intestine_morphology0.76150442
125MP0010771_integument_phenotype0.76018598
126MP0001243_abnormal_dermal_layer0.75462822
127MP0003119_abnormal_digestive_system0.74129865
128MP0008469_abnormal_protein_level0.73698771
129MP0005621_abnormal_cell_physiology0.73566303
130MP0005075_abnormal_melanosome_morpholog0.72683684
131MP0003191_abnormal_cellular_cholesterol0.70665972
132MP0003866_abnormal_defecation0.70044548
133MP0003890_abnormal_embryonic-extraembry0.69372424
134MP0002653_abnormal_ependyma_morphology0.68764349
135MP0006036_abnormal_mitochondrial_physio0.68479190

Predicted human phenotypes

RankGene SetZ-score
1Cholecystitis (HP:0001082)5.15415458
2Abnormal gallbladder physiology (HP:0012438)5.15415458
3Microvesicular hepatic steatosis (HP:0001414)4.69680965
4Birth length less than 3rd percentile (HP:0003561)3.85170645
5Abnormal number of erythroid precursors (HP:0012131)3.83235175
6Thrombocytosis (HP:0001894)3.79627743
7Abnormality of cells of the erythroid lineage (HP:0012130)3.75059276
8J-shaped sella turcica (HP:0002680)3.45596955
9Reticulocytopenia (HP:0001896)3.43731483
10IgM deficiency (HP:0002850)3.40001717
11Hyperacusis (HP:0010780)3.31907356
12Aplastic anemia (HP:0001915)3.15732673
13Ragged-red muscle fibers (HP:0003200)3.12480745
14Petechiae (HP:0000967)3.11921920
15Progressive muscle weakness (HP:0003323)3.11901593
16B lymphocytopenia (HP:0010976)3.03054819
17Abnormality of B cell number (HP:0010975)3.03054819
18Abnormality of the anterior horn cell (HP:0006802)3.02752830
19Degeneration of anterior horn cells (HP:0002398)3.02752830
20Upper limb amyotrophy (HP:0009129)2.93195177
21Distal upper limb amyotrophy (HP:0007149)2.93195177
22Colon cancer (HP:0003003)2.91770124
23Reticulocytosis (HP:0001923)2.91510249
24Hand muscle atrophy (HP:0009130)2.83067170
25Type I transferrin isoform profile (HP:0003642)2.79799898
26Nuclear cataract (HP:0100018)2.79687889
27Cholelithiasis (HP:0001081)2.78196302
28Abnormality of glycolysis (HP:0004366)2.77552705
29Breast hypoplasia (HP:0003187)2.73885052
30Oral leukoplakia (HP:0002745)2.73631160
3111 pairs of ribs (HP:0000878)2.69413734
32Long palpebral fissure (HP:0000637)2.67782988
33Testicular atrophy (HP:0000029)2.67395839
34Agnosia (HP:0010524)2.66056703
35Selective tooth agenesis (HP:0001592)2.63780189
36Squamous cell carcinoma (HP:0002860)2.63160488
37Insomnia (HP:0100785)2.62732227
38Abnormality of reticulocytes (HP:0004312)2.56213284
39Achilles tendon contracture (HP:0001771)2.55289670
40Panhypogammaglobulinemia (HP:0003139)2.52438524
41Dysostosis multiplex (HP:0000943)2.52325995
42Abnormality of glycolipid metabolism (HP:0010969)2.51194318
43Abnormality of liposaccharide metabolism (HP:0010968)2.51194318
44Abnormality of glycosphingolipid metabolism (HP:0004343)2.51194318
45Carpal bone hypoplasia (HP:0001498)2.51010584
46Patellar aplasia (HP:0006443)2.47709723
47Personality changes (HP:0000751)2.44246728
48Macrocytic anemia (HP:0001972)2.42872097
49Progressive external ophthalmoplegia (HP:0000590)2.42862518
50Rough bone trabeculation (HP:0100670)2.42579038
51Multiple enchondromatosis (HP:0005701)2.41959321
52Vertebral compression fractures (HP:0002953)2.38204065
53Mucopolysacchariduria (HP:0008155)2.35842976
54Urinary glycosaminoglycan excretion (HP:0003541)2.35842976
55Microretrognathia (HP:0000308)2.34489670
56Broad distal phalanx of finger (HP:0009836)2.32545696
57Ependymoma (HP:0002888)2.31629558
58Trismus (HP:0000211)2.31303628
59Medulloblastoma (HP:0002885)2.30286659
60Lymphoma (HP:0002665)2.30266812
61Aplasia/Hypoplasia of the patella (HP:0006498)2.28932472
62Megaloblastic anemia (HP:0001889)2.28405466
63Impulsivity (HP:0100710)2.27951492
64Abnormality of the thoracic spine (HP:0100711)2.27613806
65Reduced antithrombin III activity (HP:0001976)2.27301454
66Abnormality of T cell physiology (HP:0011840)2.27109880
67Recurrent bronchitis (HP:0002837)2.26051005
68Hypertensive crisis (HP:0100735)2.25605746
69Neuronal loss in central nervous system (HP:0002529)2.22897218
70Aplasia/Hypoplasia of the sacrum (HP:0008517)2.22500500
71Abnormality of the Achilles tendon (HP:0005109)2.21668532
72Recurrent viral infections (HP:0004429)2.20617258
73Combined immunodeficiency (HP:0005387)2.20074042
74Hyperthyroidism (HP:0000836)2.19062774
75Abnormal gallbladder morphology (HP:0012437)2.17441782
76Abnormal protein glycosylation (HP:0012346)2.16326896
77Abnormal glycosylation (HP:0012345)2.16326896
78Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.16326896
79Abnormal protein N-linked glycosylation (HP:0012347)2.16326896
80Basal cell carcinoma (HP:0002671)2.14957998
81Distal lower limb amyotrophy (HP:0008944)2.14567964
82Thoracic kyphosis (HP:0002942)2.14079214
83Neoplasm of the pancreas (HP:0002894)2.13511544
84Upper limb muscle weakness (HP:0003484)2.12758782
85Cervical subluxation (HP:0003308)2.08689716
86Abnormality of polysaccharide metabolism (HP:0011012)2.08005359
87Abnormality of glycosaminoglycan metabolism (HP:0004371)2.08005359
88Abnormality of mucopolysaccharide metabolism (HP:0011020)2.08005359
89Upper motor neuron abnormality (HP:0002127)2.07561580
90Abnormality of the gallbladder (HP:0005264)2.07119476
91Poikiloderma (HP:0001029)2.06843110
92Seborrheic dermatitis (HP:0001051)2.06234467
93Severe combined immunodeficiency (HP:0004430)2.05998687
94Abnormality of T cells (HP:0002843)2.04972141
95Myelodysplasia (HP:0002863)2.04505898
96Increased serum ferritin (HP:0003281)2.04260999
97Prolonged neonatal jaundice (HP:0006579)2.03810299
98Prominent metopic ridge (HP:0005487)2.03542388
99Pallor (HP:0000980)2.02943846
100Polygenic inheritance (HP:0010982)2.00252811
101Atrophy/Degeneration involving motor neurons (HP:0007373)2.00212355
102Deep palmar crease (HP:0006191)1.99853164
103Asymmetry of the thorax (HP:0001555)1.99579725
104Cellular immunodeficiency (HP:0005374)1.99380287
105Hepatosplenomegaly (HP:0001433)1.94935914
106Tongue fasciculations (HP:0001308)1.94535234
107Pointed chin (HP:0000307)1.94505319
108Loss of speech (HP:0002371)1.94010681
109Bone marrow hypocellularity (HP:0005528)1.92679135
110Hypoplasia of the thymus (HP:0000778)1.91624592
111Absent thumb (HP:0009777)1.90173921
112IgG deficiency (HP:0004315)1.89896681
113Premature graying of hair (HP:0002216)1.89783947
114Increased serum pyruvate (HP:0003542)1.89290647
115Elevated erythrocyte sedimentation rate (HP:0003565)1.89191909
116Granulocytopenia (HP:0001913)1.89178056
117Abnormality of cells of the lymphoid lineage (HP:0012140)1.88433283
118Amaurosis fugax (HP:0100576)1.87131160
119Hypoplasia of the capital femoral epiphysis (HP:0003090)1.85382256
120Growth hormone excess (HP:0000845)1.84818051
121Chronic obstructive pulmonary disease (HP:0006510)1.83235164
122Obstructive lung disease (HP:0006536)1.83235164
123Disproportionate tall stature (HP:0001519)1.82957573
124Lymphopenia (HP:0001888)1.82907797
125Myopathic facies (HP:0002058)1.82186351
126Pancytopenia (HP:0001876)1.81533076
127Abnormality of homocysteine metabolism (HP:0010919)1.81461197
128Homocystinuria (HP:0002156)1.81461197
129Abnormality of chromosome stability (HP:0003220)1.81029891
130Centrally nucleated skeletal muscle fibers (HP:0003687)1.80712082
131Late onset (HP:0003584)1.80435779
132Abnormal trabecular bone morphology (HP:0100671)1.80142017
133IgA deficiency (HP:0002720)1.80050809
134Deformed sella turcica (HP:0002681)1.79492055
135Colitis (HP:0002583)1.76927771
136Abnormality of the vasculature of the conjunctiva (HP:0008054)1.76751322
137Cerebral hypomyelination (HP:0006808)1.75821683
138Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.74515568
139Missing ribs (HP:0000921)1.73499425
140Abnormality of small intestinal villus morphology (HP:0011472)1.73256095
141Villous atrophy (HP:0011473)1.73256095
142Poor head control (HP:0002421)1.72850378
143Severe short stature (HP:0003510)1.72467547
144Elfin facies (HP:0004428)1.72393296
145Global brain atrophy (HP:0002283)1.71461996
146Cellulitis (HP:0100658)1.70593142
147Flattened epiphyses (HP:0003071)1.70389652
148Optic nerve coloboma (HP:0000588)1.70221015
149Slender long bone (HP:0003100)1.69814046
150Freckling (HP:0001480)1.69480671
151Mediastinal lymphadenopathy (HP:0100721)1.69326290
152Cutaneous melanoma (HP:0012056)1.67635607
153Apathy (HP:0000741)1.67413716
154Premature rupture of membranes (HP:0001788)1.67251447
155Abnormal delayed hypersensitivity skin test (HP:0002963)1.66107166
156Agammaglobulinemia (HP:0004432)1.65656497
157Vacuolated lymphocytes (HP:0001922)1.65437289
158Aplasia/Hypoplasia of the thymus (HP:0010515)1.64855397
159Broad face (HP:0000283)1.64618267
160Diminished motivation (HP:0000745)1.64044881
161Rhabdomyosarcoma (HP:0002859)1.63563255
162Axonal loss (HP:0003447)1.63281792
163Orthostatic hypotension (HP:0001278)1.63240278
164Peripheral hypomyelination (HP:0007182)1.63039671
165Prominent nose (HP:0000448)1.62994214
166Abnormality of the preputium (HP:0100587)1.62626968
167Recurrent fungal infections (HP:0002841)1.62173341
168Muscle fibrillation (HP:0010546)1.62101739
169Entropion (HP:0000621)1.61636604
170Abnormality of the motor neurons (HP:0002450)1.61575156
171Abnormal neuron morphology (HP:0012757)1.61575156
172Increased cerebral lipofuscin (HP:0011813)1.60365850
173Absent epiphyses (HP:0010577)1.59363016
174Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.59363016
175Athetosis (HP:0002305)1.59156971
176Biconcave vertebral bodies (HP:0004586)1.58220839
177Truncus arteriosus (HP:0001660)1.56890735
178Supranuclear gaze palsy (HP:0000605)1.52169657
179Severe visual impairment (HP:0001141)1.52062184
180Distal lower limb muscle weakness (HP:0009053)1.51545606

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.10287773
2SMG13.93165736
3WEE13.20841626
4MAP4K12.90560932
5VRK22.86416208
6PASK2.84876093
7CDC72.79054853
8PRPF4B2.44814168
9TSSK62.36546850
10ICK2.35812291
11FLT32.23385399
12NEK22.20837589
13EIF2AK12.11725863
14BRSK22.10106442
15ACVR1B2.02244629
16NME22.00554972
17ARAF1.94733346
18SIK11.90247422
19MAP3K101.86571016
20TESK21.85569581
21PLK41.76109272
22SRPK11.75802721
23SCYL21.68648760
24CCNB11.66148218
25TTK1.63815634
26EIF2AK31.63738792
27STK161.62981808
28KDR1.60284548
29CSF1R1.55070031
30EEF2K1.51423383
31ATR1.49583946
32STK101.49359929
33BRSK11.48394012
34SIK21.46009885
35PKN21.45590632
36RPS6KA41.44590942
37ERN11.41970202
38PLK11.39840774
39CDK71.39658642
40TESK11.38937418
41RPS6KB21.34832629
42TLK11.30121256
43BTK1.26281485
44ZAP701.25784234
45BCKDK1.25504099
46AURKB1.24224283
47MAP3K81.23893014
48TGFBR11.22760205
49VRK11.21718309
50MAPK151.20529789
51DYRK31.20017800
52MAP3K111.18372953
53PIM21.18004126
54CDK41.17776537
55SIK31.17567226
56RIPK41.07361791
57KIT1.07263396
58EPHA21.06190840
59NEK11.03797084
60PIM11.02861304
61GRK61.01603919
62MKNK10.98209446
63CHEK20.97823459
64PAK40.95688494
65MAPK110.95200583
66AURKA0.90117915
67MAP2K30.89635079
68IRAK40.87353525
69LMTK20.85856507
70ILK0.82697277
71MAP3K130.82495527
72LIMK10.81931815
73CHEK10.80851210
74MAP3K30.80615964
75TEC0.80404412
76CDK120.80110374
77FGFR40.78212012
78MAP2K20.77792626
79BRD40.74969405
80PLK30.74285584
81LRRK20.72117297
82STK40.71112156
83BLK0.71110076
84MAP2K60.70939443
85PTK60.70800312
86SYK0.70533119
87TBK10.68958296
88CLK10.67011414
89TYK20.66649592
90IRAK30.65590680
91TAOK30.65494752
92CDK90.65048032
93JAK30.64643765
94TGFBR20.64627326
95RIPK10.63783441
96TAOK20.63331108
97CDK20.63105542
98CHUK0.60590313
99CSNK2A20.59471301
100CDK80.59227044
101CDK11A0.59148761
102MAP3K10.58313724
103PDK20.56592103
104PRKCI0.56241284
105CSNK2A10.55763672
106MKNK20.55679243
107PTK20.55378439
108ATM0.55244053
109ALK0.54842261
110ZAK0.54231180
111TRIB30.54110596
112CDK150.53720132
113PRKD30.52829634
114LYN0.52728476
115EIF2AK20.52525256
116DAPK30.51812243
117TAF10.51753518
118TAOK10.51744753
119NME10.51305770
120PRKD20.50037057
121CDK180.49169546
122RPS6KA20.48009808
123ABL20.47340698
124AKT20.46566419
125NTRK10.46023663
126CDK140.45929886
127RAF10.45235867
128MAPKAPK30.44745386
129BRAF0.44623292
130PDPK10.43022149
131DAPK10.42656980
132IRAK20.42137180
133PAK10.40530651
134MARK20.40198378
135EPHB10.40186099
136NLK0.39017157
137IKBKB0.38261308
138LCK0.35170697
139HIPK20.34355016
140RPS6KC10.34102554
141RPS6KL10.34102554
142MAP3K140.34025029
143MTOR0.33697775
144BMX0.32427292
145CDK60.31930774
146CDK10.31381022

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.60128001
2Mismatch repair_Homo sapiens_hsa034303.73988781
3Base excision repair_Homo sapiens_hsa034103.13994331
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.01067240
5Spliceosome_Homo sapiens_hsa030402.94347290
6One carbon pool by folate_Homo sapiens_hsa006702.91582663
7RNA polymerase_Homo sapiens_hsa030202.90524542
8Proteasome_Homo sapiens_hsa030502.90299314
9Ribosome_Homo sapiens_hsa030102.88388780
10RNA transport_Homo sapiens_hsa030132.54999566
11Nucleotide excision repair_Homo sapiens_hsa034202.44252281
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.41516223
13Homologous recombination_Homo sapiens_hsa034402.38108810
14Pyrimidine metabolism_Homo sapiens_hsa002402.30830265
15Non-homologous end-joining_Homo sapiens_hsa034502.19359345
16Cell cycle_Homo sapiens_hsa041102.12876706
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.11943667
18Selenocompound metabolism_Homo sapiens_hsa004502.05191014
19Fatty acid elongation_Homo sapiens_hsa000621.68692136
20Primary immunodeficiency_Homo sapiens_hsa053401.53346127
21Protein export_Homo sapiens_hsa030601.50999615
22Antigen processing and presentation_Homo sapiens_hsa046121.47004360
23Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.42447000
24RNA degradation_Homo sapiens_hsa030181.41819512
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.35832186
26Folate biosynthesis_Homo sapiens_hsa007901.32210474
27p53 signaling pathway_Homo sapiens_hsa041151.32004561
28mRNA surveillance pathway_Homo sapiens_hsa030151.29811214
29Fanconi anemia pathway_Homo sapiens_hsa034601.28657598
30Other glycan degradation_Homo sapiens_hsa005111.26814978
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.26490075
32Vibrio cholerae infection_Homo sapiens_hsa051101.26268433
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.21466582
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.21106005
35Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.20975775
36Purine metabolism_Homo sapiens_hsa002301.18391380
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.17888996
38Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.15928244
39Epstein-Barr virus infection_Homo sapiens_hsa051691.14464497
40Basal transcription factors_Homo sapiens_hsa030221.12123823
41Non-small cell lung cancer_Homo sapiens_hsa052231.09895514
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.05702877
43Legionellosis_Homo sapiens_hsa051341.05607383
44Pentose phosphate pathway_Homo sapiens_hsa000301.04038143
45Sulfur relay system_Homo sapiens_hsa041221.03024541
46Herpes simplex infection_Homo sapiens_hsa051681.02700389
47N-Glycan biosynthesis_Homo sapiens_hsa005101.00742046
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.98661452
49Biosynthesis of amino acids_Homo sapiens_hsa012300.96917430
50Galactose metabolism_Homo sapiens_hsa000520.96805319
51Fructose and mannose metabolism_Homo sapiens_hsa000510.92120282
52Systemic lupus erythematosus_Homo sapiens_hsa053220.89967464
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.86953864
54Viral carcinogenesis_Homo sapiens_hsa052030.85712096
55Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.82434085
56Prion diseases_Homo sapiens_hsa050200.80981566
57Pancreatic cancer_Homo sapiens_hsa052120.80747985
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.80520711
59VEGF signaling pathway_Homo sapiens_hsa043700.79979989
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78508393
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.76057346
62Salmonella infection_Homo sapiens_hsa051320.75728949
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.74164849
64HTLV-I infection_Homo sapiens_hsa051660.67899448
65Thyroid cancer_Homo sapiens_hsa052160.67833928
66Endometrial cancer_Homo sapiens_hsa052130.64173196
67Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63434327
68Synaptic vesicle cycle_Homo sapiens_hsa047210.62473087
69Carbon metabolism_Homo sapiens_hsa012000.61084242
70Measles_Homo sapiens_hsa051620.59103360
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58610595
72B cell receptor signaling pathway_Homo sapiens_hsa046620.57800454
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56671809
74Insulin signaling pathway_Homo sapiens_hsa049100.56268254
75Shigellosis_Homo sapiens_hsa051310.54175448
76Apoptosis_Homo sapiens_hsa042100.52824300
77Renin-angiotensin system_Homo sapiens_hsa046140.52060927
78Hepatitis C_Homo sapiens_hsa051600.51901859
79mTOR signaling pathway_Homo sapiens_hsa041500.50668906
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49981760
81Lysosome_Homo sapiens_hsa041420.49738511
82Leishmaniasis_Homo sapiens_hsa051400.48894653
83Hematopoietic cell lineage_Homo sapiens_hsa046400.47895710
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47535575
85Lysine degradation_Homo sapiens_hsa003100.47250450
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45399499
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.44915424
88Acute myeloid leukemia_Homo sapiens_hsa052210.44685285
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44419493
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44407196
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.44065123
92Endocytosis_Homo sapiens_hsa041440.44042656
93Pyruvate metabolism_Homo sapiens_hsa006200.43163822
94AMPK signaling pathway_Homo sapiens_hsa041520.42395512
95Viral myocarditis_Homo sapiens_hsa054160.42138696
96Glioma_Homo sapiens_hsa052140.41998564
97Vitamin B6 metabolism_Homo sapiens_hsa007500.40832921
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40649076
99Small cell lung cancer_Homo sapiens_hsa052220.38789440
1002-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.38640350
101ErbB signaling pathway_Homo sapiens_hsa040120.37427938
102Influenza A_Homo sapiens_hsa051640.37111705
103Intestinal immune network for IgA production_Homo sapiens_hsa046720.35417253
104Hepatitis B_Homo sapiens_hsa051610.35266808
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.34538577
106Renal cell carcinoma_Homo sapiens_hsa052110.34291039
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33586737
108Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32957878
109Tuberculosis_Homo sapiens_hsa051520.32204828
110Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31567768
111Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.31437141
112Glutathione metabolism_Homo sapiens_hsa004800.30979173
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.29685071
114Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.29035119
115Oocyte meiosis_Homo sapiens_hsa041140.28375152
116Chronic myeloid leukemia_Homo sapiens_hsa052200.27350855
117Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27342576
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.26476465
119Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.26400963
120Notch signaling pathway_Homo sapiens_hsa043300.22037694
121Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.19503109
122Leukocyte transendothelial migration_Homo sapiens_hsa046700.18985777
123Metabolic pathways_Homo sapiens_hsa011000.17595760
124HIF-1 signaling pathway_Homo sapiens_hsa040660.17574006
125Arachidonic acid metabolism_Homo sapiens_hsa005900.15692989
126NOD-like receptor signaling pathway_Homo sapiens_hsa046210.15653014
127Type I diabetes mellitus_Homo sapiens_hsa049400.15512081
128Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.15097857
129Pertussis_Homo sapiens_hsa051330.14131593
130Bladder cancer_Homo sapiens_hsa052190.13800830
131Colorectal cancer_Homo sapiens_hsa052100.11968089
132Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.11557529
133Toll-like receptor signaling pathway_Homo sapiens_hsa046200.10455451
134Alcoholism_Homo sapiens_hsa050340.10178762
135Jak-STAT signaling pathway_Homo sapiens_hsa046300.09569720

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