DDX47

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)6.95801122
2DNA deamination (GO:0045006)6.25184538
3replication fork processing (GO:0031297)6.06356998
4transcription from mitochondrial promoter (GO:0006390)5.84373724
5formation of translation preinitiation complex (GO:0001731)5.33074693
6maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.30978423
7viral mRNA export from host cell nucleus (GO:0046784)5.20705142
8telomere maintenance via semi-conservative replication (GO:0032201)5.00850984
9embryonic process involved in female pregnancy (GO:0060136)4.96151561
10proline metabolic process (GO:0006560)4.91456349
11somatic diversification of immune receptors via somatic mutation (GO:0002566)4.82515829
12somatic hypermutation of immunoglobulin genes (GO:0016446)4.82515829
13DNA strand elongation involved in DNA replication (GO:0006271)4.57347477
14negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.49889824
15DNA strand elongation (GO:0022616)4.33582307
16telomere maintenance via recombination (GO:0000722)4.32902480
17regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.31702881
18positive regulation of protein homooligomerization (GO:0032464)4.28640658
19positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.24147771
20nucleotide-excision repair, DNA gap filling (GO:0006297)4.21453124
21anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.16930897
22mitochondrial DNA metabolic process (GO:0032042)4.16910078
23establishment of integrated proviral latency (GO:0075713)4.13856676
24negative regulation of ligase activity (GO:0051352)4.09008376
25negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.09008376
26regulation of integrin activation (GO:0033623)4.07608151
27chromatin remodeling at centromere (GO:0031055)4.07475079
28DNA strand renaturation (GO:0000733)4.05515162
29oxidative demethylation (GO:0070989)3.99893243
30CENP-A containing nucleosome assembly (GO:0034080)3.99544959
31mitotic G1 DNA damage checkpoint (GO:0031571)3.98017033
32base-excision repair (GO:0006284)3.97438096
33establishment of apical/basal cell polarity (GO:0035089)3.96370492
34negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.95079725
35meiotic chromosome segregation (GO:0045132)3.93565227
36mRNA cleavage (GO:0006379)3.92474875
37poly(A)+ mRNA export from nucleus (GO:0016973)3.90130602
38regulation of cellular amino acid metabolic process (GO:0006521)3.89828236
39ribosome assembly (GO:0042255)3.87933929
40mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.86035361
41DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.85583364
42signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.83543747
43signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.83543747
44signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.83543747
45intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.80423888
46signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.80423888
47mitotic recombination (GO:0006312)3.80100717
48telomere maintenance via telomere lengthening (GO:0010833)3.74974735
49maturation of 5.8S rRNA (GO:0000460)3.72848040
50signal transduction involved in DNA integrity checkpoint (GO:0072401)3.69606741
51signal transduction involved in DNA damage checkpoint (GO:0072422)3.69606741
52positive regulation of mitotic sister chromatid separation (GO:1901970)3.69100523
53positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.69100523
54positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.69100523
55signal transduction involved in cell cycle checkpoint (GO:0072395)3.65938769
56protein neddylation (GO:0045116)3.63583566
57regulation of double-strand break repair via homologous recombination (GO:0010569)3.63019218
58DNA double-strand break processing (GO:0000729)3.61246451
59positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.60818847
60kinetochore assembly (GO:0051382)3.60218752
61DNA topological change (GO:0006265)3.59777890
62ribosome biogenesis (GO:0042254)3.55341543
63DNA damage response, detection of DNA damage (GO:0042769)3.54815148
64establishment of protein localization to mitochondrial membrane (GO:0090151)3.52223086
65G1 DNA damage checkpoint (GO:0044783)3.51887355
66spliceosomal tri-snRNP complex assembly (GO:0000244)3.51764259
67double-strand break repair via nonhomologous end joining (GO:0006303)3.51034566
68non-recombinational repair (GO:0000726)3.51034566
69positive regulation of ligase activity (GO:0051351)3.50753730
70mitochondrial RNA metabolic process (GO:0000959)3.50492171
71regulation of translational fidelity (GO:0006450)3.48124553
72regulation of protein homooligomerization (GO:0032462)3.46319018
73positive regulation of chromosome segregation (GO:0051984)3.45930271
74termination of RNA polymerase II transcription (GO:0006369)3.44821986
75chaperone-mediated protein transport (GO:0072321)3.44165416
76regulation of sister chromatid cohesion (GO:0007063)3.44163098
77mitotic G1/S transition checkpoint (GO:0044819)3.40002115
78ribosomal large subunit biogenesis (GO:0042273)3.38899543
79kinetochore organization (GO:0051383)3.37787679
80histone exchange (GO:0043486)3.37569539
81metaphase plate congression (GO:0051310)3.37306025
82negative regulation of mRNA processing (GO:0050686)3.36652871
83DNA integration (GO:0015074)3.36146894
84negative regulation of RNA splicing (GO:0033119)3.35679961
85rRNA modification (GO:0000154)3.35600343
86establishment of monopolar cell polarity (GO:0061162)3.33860213
87establishment or maintenance of monopolar cell polarity (GO:0061339)3.33860213
88establishment of viral latency (GO:0019043)3.33740278
89ATP synthesis coupled proton transport (GO:0015986)3.28524582
90energy coupled proton transport, down electrochemical gradient (GO:0015985)3.28524582
91protein localization to kinetochore (GO:0034501)3.28078803
92regulation of ubiquitin-protein transferase activity (GO:0051438)3.27211759
93mitotic sister chromatid segregation (GO:0000070)3.26989735
94dosage compensation (GO:0007549)3.25673706
95regulation of DNA damage checkpoint (GO:2000001)3.25662647
96nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.22673533
97regulation of mitotic spindle checkpoint (GO:1903504)3.22278035
98regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.22278035
99exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.21768647
100DNA replication initiation (GO:0006270)3.20410972
101regulation of ligase activity (GO:0051340)3.20222131
102RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.19437360
103tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.19437360
104DNA ligation (GO:0006266)3.19016207
105mitotic nuclear envelope disassembly (GO:0007077)3.18635992
106spindle checkpoint (GO:0031577)3.15233299
107base-excision repair, AP site formation (GO:0006285)3.13861504
108DNA catabolic process, exonucleolytic (GO:0000738)3.13826734
109protein targeting to mitochondrion (GO:0006626)3.12658247
110pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.10491257
111DNA replication-independent nucleosome organization (GO:0034724)3.08600737
112DNA replication-independent nucleosome assembly (GO:0006336)3.08600737
113transcription elongation from RNA polymerase III promoter (GO:0006385)3.07654273
114termination of RNA polymerase III transcription (GO:0006386)3.07654273
115nucleobase biosynthetic process (GO:0046112)3.07509614
116mitotic spindle checkpoint (GO:0071174)3.07431169
117tRNA aminoacylation for protein translation (GO:0006418)3.07198152
118ribosomal small subunit assembly (GO:0000028)3.07060433
119cullin deneddylation (GO:0010388)3.06413323
120negative regulation of cell cycle arrest (GO:0071157)3.03707094
121tRNA aminoacylation (GO:0043039)3.03325743
122amino acid activation (GO:0043038)3.03325743
123regulation of double-strand break repair (GO:2000779)3.03046217
124DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.01836057
125DNA replication-dependent nucleosome assembly (GO:0006335)3.01738065
126DNA replication-dependent nucleosome organization (GO:0034723)3.01738065
127mRNA export from nucleus (GO:0006406)3.01002120
128rRNA methylation (GO:0031167)3.00563216
129negative regulation of protein ubiquitination (GO:0031397)2.98629670
130cellular response to zinc ion (GO:0071294)2.98435084
131negative regulation of JAK-STAT cascade (GO:0046426)2.98422935
132IMP biosynthetic process (GO:0006188)2.96780618
133GDP-mannose metabolic process (GO:0019673)2.95529882
134protein localization to mitochondrion (GO:0070585)2.95463837
135ribonucleoprotein complex biogenesis (GO:0022613)2.93818324
136regulation of mitochondrial translation (GO:0070129)2.92528981
137pseudouridine synthesis (GO:0001522)2.92375138
138water-soluble vitamin biosynthetic process (GO:0042364)2.91929493
139spliceosomal snRNP assembly (GO:0000387)2.91181196
140regulation of RNA export from nucleus (GO:0046831)2.90465788
141mitochondrial DNA replication (GO:0006264)2.89962546
142translational initiation (GO:0006413)2.89960003
143G1/S transition of mitotic cell cycle (GO:0000082)2.89629468
144cell cycle G1/S phase transition (GO:0044843)2.89629468
145negative regulation of mitotic sister chromatid separation (GO:2000816)2.89477761
146negative regulation of sister chromatid segregation (GO:0033046)2.89477761
147negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.89477761
148negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.89477761
149negative regulation of mitotic sister chromatid segregation (GO:0033048)2.89477761
150RNA export from nucleus (GO:0006405)2.89389731
151mitotic metaphase plate congression (GO:0007080)2.89079584
152positive regulation of cell cycle arrest (GO:0071158)2.88380767
153lactate metabolic process (GO:0006089)2.87909719
154membrane disassembly (GO:0030397)2.87471622
155nuclear envelope disassembly (GO:0051081)2.87471622
156establishment of protein localization to mitochondrion (GO:0072655)2.87098883
157DNA replication checkpoint (GO:0000076)2.86660075
158proteasome assembly (GO:0043248)2.86506902
159protein deneddylation (GO:0000338)2.86503678
160transcription-coupled nucleotide-excision repair (GO:0006283)2.85818419
161negative regulation of chromosome segregation (GO:0051985)2.85777965
162* rRNA processing (GO:0006364)2.85335747
163purine nucleobase biosynthetic process (GO:0009113)2.83908844
164resolution of meiotic recombination intermediates (GO:0000712)2.82709364
165positive regulation of developmental pigmentation (GO:0048087)2.77528858
166* rRNA metabolic process (GO:0016072)2.75083138
167sister chromatid segregation (GO:0000819)2.74999159
168maturation of SSU-rRNA (GO:0030490)2.73652862
169negative regulation of mRNA metabolic process (GO:1903312)2.73501753
170regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.73418818
171telomere maintenance (GO:0000723)2.73186694
172telomere organization (GO:0032200)2.72238669

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.77817323
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.92719415
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.46676211
4FOXM1_23109430_ChIP-Seq_U2OS_Human2.98044250
5MYC_19079543_ChIP-ChIP_MESCs_Mouse2.84968489
6MYC_18358816_ChIP-ChIP_MESCs_Mouse2.76794000
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.64829551
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.57825946
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.56610967
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.52649526
11* ETS1_20019798_ChIP-Seq_JURKAT_Human2.44467013
12* EST1_17652178_ChIP-ChIP_JURKAT_Human2.24570702
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.22703568
14SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.21614936
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.18177553
16PADI4_21655091_ChIP-ChIP_MCF-7_Human2.10956410
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.09496417
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.02241169
19VDR_21846776_ChIP-Seq_THP-1_Human1.99068401
20* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.96772346
21NELFA_20434984_ChIP-Seq_ESCs_Mouse1.96273732
22MYC_22102868_ChIP-Seq_BL_Human1.91783033
23XRN2_22483619_ChIP-Seq_HELA_Human1.90596068
24* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.87819774
25* VDR_23849224_ChIP-Seq_CD4+_Human1.86530731
26GABP_19822575_ChIP-Seq_HepG2_Human1.85035486
27DCP1A_22483619_ChIP-Seq_HELA_Human1.79473484
28MYC_18940864_ChIP-ChIP_HL60_Human1.79429386
29ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.79308127
30NANOG_18555785_ChIP-Seq_MESCs_Mouse1.78646615
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.77721240
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.75946458
33CREB1_15753290_ChIP-ChIP_HEK293T_Human1.73139296
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.71395063
35DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.70583322
36PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.67535142
37KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.66630284
38KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.66630284
39KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.66630284
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.65225773
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.63887862
42* YY1_21170310_ChIP-Seq_MESCs_Mouse1.58543345
43KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.58487684
44* TTF2_22483619_ChIP-Seq_HELA_Human1.58379358
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.57450228
46KDM5A_27292631_Chip-Seq_BREAST_Human1.56665107
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.54015827
48POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.53510125
49STAT3_1855785_ChIP-Seq_MESCs_Mouse1.51904788
50* FOXP3_21729870_ChIP-Seq_TREG_Human1.51600885
51EWS_26573619_Chip-Seq_HEK293_Human1.51412637
52CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.51101321
53ELF1_17652178_ChIP-ChIP_JURKAT_Human1.49501806
54ZNF274_21170338_ChIP-Seq_K562_Hela1.47040941
55SALL1_21062744_ChIP-ChIP_HESCs_Human1.46606067
56FUS_26573619_Chip-Seq_HEK293_Human1.46539567
57NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.43740028
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43180580
59NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.43035684
60MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.40771769
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39994483
62HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.39664357
63KLF4_18555785_ChIP-Seq_MESCs_Mouse1.39171950
64NANOG_21062744_ChIP-ChIP_HESCs_Human1.37056572
65VDR_22108803_ChIP-Seq_LS180_Human1.36376301
66SRF_21415370_ChIP-Seq_HL-1_Mouse1.35266106
67BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.34722498
68* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.34656979
69SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.31195612
70SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.30874715
71SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.30235146
72FLI1_27457419_Chip-Seq_LIVER_Mouse1.30056587
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27609389
74DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.26123746
75* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.24628542
76SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23859245
77RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23850842
78* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23621069
79POU5F1_16153702_ChIP-ChIP_HESCs_Human1.23615671
80TFEB_21752829_ChIP-Seq_HELA_Human1.23493004
81NANOG_16153702_ChIP-ChIP_HESCs_Human1.22448616
82ELK1_22589737_ChIP-Seq_MCF10A_Human1.21084256
83* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.19975278
84CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.19389244
85MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18712176
86TCF3_18692474_ChIP-Seq_MEFs_Mouse1.18587166
87PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16953242
88EGR1_19374776_ChIP-ChIP_THP-1_Human1.16842644
89FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16813379
90SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.14916983
91HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14910596
92FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.14907865
93CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14695192
94NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.14450377
95TCF3_18692474_ChIP-Seq_MESCs_Mouse1.13139152
96POU5F1_16518401_ChIP-PET_MESCs_Mouse1.12350616
97CIITA_25753668_ChIP-Seq_RAJI_Human1.12301852
98RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12143857
99SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10977465
100AR_21909140_ChIP-Seq_LNCAP_Human1.10335559
101ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09759929
102* ELK1_19687146_ChIP-ChIP_HELA_Human1.09404495
103SOX2_16153702_ChIP-ChIP_HESCs_Human1.07075310
104NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.06126530
105CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05869487
106NOTCH1_21737748_ChIP-Seq_TLL_Human1.04401102
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04208069
108ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03300492
109E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02128709
110ERG_20887958_ChIP-Seq_HPC-7_Mouse1.01980950
111CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.00232219
112SPI1_23547873_ChIP-Seq_NB4_Human0.98958563
113POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.97777056
114IRF1_19129219_ChIP-ChIP_H3396_Human0.97592335
115HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.97127663
116SOX2_18692474_ChIP-Seq_MEFs_Mouse0.96627085
117OCT4_18692474_ChIP-Seq_MEFs_Mouse0.96288230
118GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94656964
119* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94067113
120SOX17_20123909_ChIP-Seq_XEN_Mouse0.92624026
121TET1_21451524_ChIP-Seq_MESCs_Mouse0.92274363
122PCGF2_27294783_Chip-Seq_ESCs_Mouse0.92106223
123E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.91872078
124TP63_19390658_ChIP-ChIP_HaCaT_Human0.91296480
125CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91086869
126PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.90163939
127TAF15_26573619_Chip-Seq_HEK293_Human0.88745357
128GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.88484409
129MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.86930165
130POU3F2_20337985_ChIP-ChIP_501MEL_Human0.84610981
131EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.77761617
132P300_19829295_ChIP-Seq_ESCs_Human0.76987023
133CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.75208681
134CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.74913541
135IGF1R_20145208_ChIP-Seq_DFB_Human0.74745300
136CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.70265071
137KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.70209651
138TP53_22573176_ChIP-Seq_HFKS_Human0.69955560
139SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.68599093
140ELF5_23300383_ChIP-Seq_T47D_Human0.68519666

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.94282283
2MP0006292_abnormal_olfactory_placode4.39259323
3MP0010094_abnormal_chromosome_stability3.97625921
4MP0003693_abnormal_embryo_hatching3.64658879
5MP0004957_abnormal_blastocyst_morpholog3.32466016
6MP0003111_abnormal_nucleus_morphology3.27518761
7MP0008058_abnormal_DNA_repair3.18163077
8MP0008789_abnormal_olfactory_epithelium2.98735412
9MP0009278_abnormal_bone_marrow2.98531867
10MP0003077_abnormal_cell_cycle2.96243737
11MP0002938_white_spotting2.72053995
12MP0002009_preneoplasia2.60241658
13MP0003786_premature_aging2.53299054
14MP0005171_absent_coat_pigmentation2.51433154
15MP0005397_hematopoietic_system_phenotyp2.40486113
16MP0001545_abnormal_hematopoietic_system2.40486113
17MP0005499_abnormal_olfactory_system2.39055136
18MP0005394_taste/olfaction_phenotype2.39055136
19MP0010030_abnormal_orbit_morphology2.36064739
20MP0008877_abnormal_DNA_methylation2.29739113
21MP0002396_abnormal_hematopoietic_system2.26259666
22MP0002102_abnormal_ear_morphology2.20029605
23MP0000490_abnormal_crypts_of2.04329026
24MP0008932_abnormal_embryonic_tissue2.01730739
25MP0008995_early_reproductive_senescence1.94904951
26MP0003186_abnormal_redox_activity1.90970475
27MP0004233_abnormal_muscle_weight1.80021250
28MP0010352_gastrointestinal_tract_polyps1.77607415
29MP0005084_abnormal_gallbladder_morpholo1.73953459
30MP0008007_abnormal_cellular_replicative1.73253734
31MP0005174_abnormal_tail_pigmentation1.70297018
32MP0000350_abnormal_cell_proliferation1.68408555
33MP0006035_abnormal_mitochondrial_morpho1.65654049
34MP0000372_irregular_coat_pigmentation1.63746075
35MP0001697_abnormal_embryo_size1.63490285
36MP0002233_abnormal_nose_morphology1.58680011
37MP0001529_abnormal_vocalization1.57272116
38MP0005075_abnormal_melanosome_morpholog1.56764718
39MP0001730_embryonic_growth_arrest1.56382655
40MP0009333_abnormal_splenocyte_physiolog1.52852627
41MP0002086_abnormal_extraembryonic_tissu1.52693761
42MP0003763_abnormal_thymus_physiology1.51438687
43MP0002019_abnormal_tumor_incidence1.48885084
44MP0001293_anophthalmia1.48831650
45MP0003890_abnormal_embryonic-extraembry1.47534751
46MP0003718_maternal_effect1.47426775
47MP0003567_abnormal_fetal_cardiomyocyte1.47144809
48MP0005380_embryogenesis_phenotype1.45576550
49MP0001672_abnormal_embryogenesis/_devel1.45576550
50MP0001984_abnormal_olfaction1.43034882
51MP0000685_abnormal_immune_system1.41176733
52MP0009697_abnormal_copulation1.41156960
53MP0006036_abnormal_mitochondrial_physio1.40594954
54MP0002084_abnormal_developmental_patter1.39697111
55MP0005408_hypopigmentation1.37930833
56MP0002085_abnormal_embryonic_tissue1.34887714
57MP0005076_abnormal_cell_differentiation1.34885416
58MP0004197_abnormal_fetal_growth/weight/1.34169204
59MP0003937_abnormal_limbs/digits/tail_de1.33259005
60MP0001286_abnormal_eye_development1.31661873
61MP0010307_abnormal_tumor_latency1.31231114
62MP0002080_prenatal_lethality1.30633462
63MP0000313_abnormal_cell_death1.30093672
64MP0000689_abnormal_spleen_morphology1.28934915
65MP0000015_abnormal_ear_pigmentation1.26780210
66MP0002398_abnormal_bone_marrow1.25772456
67MP0003119_abnormal_digestive_system1.24745125
68MP0002166_altered_tumor_susceptibility1.23974513
69MP0009053_abnormal_anal_canal1.23041421
70MP0003984_embryonic_growth_retardation1.21457620
71MP0000371_diluted_coat_color1.17349351
72MP0002088_abnormal_embryonic_growth/wei1.16544460
73MP0004133_heterotaxia1.14746625
74MP0002405_respiratory_system_inflammati1.13884909
75MP0004264_abnormal_extraembryonic_tissu1.12552205
76MP0003121_genomic_imprinting1.11965465
77MP0004808_abnormal_hematopoietic_stem1.11601591
78MP0002234_abnormal_pharynx_morphology1.09831555
79MP0002722_abnormal_immune_system1.09528645
80MP0000703_abnormal_thymus_morphology1.08664384
81MP0003806_abnormal_nucleotide_metabolis1.06487603
82MP0005395_other_phenotype1.02928267
83MP0002132_abnormal_respiratory_system1.01820209
84MP0003755_abnormal_palate_morphology1.01077063
85MP0003453_abnormal_keratinocyte_physiol0.99816919
86MP0003656_abnormal_erythrocyte_physiolo0.99040484
87MP0003172_abnormal_lysosome_physiology0.98867490
88MP0002006_tumorigenesis0.98711163
89MP0002751_abnormal_autonomic_nervous0.98670748
90MP0006072_abnormal_retinal_apoptosis0.95671931
91MP0000647_abnormal_sebaceous_gland0.94496280
92MP0002095_abnormal_skin_pigmentation0.94242992
93MP0001929_abnormal_gametogenesis0.92956846
94MP0000470_abnormal_stomach_morphology0.92865310
95MP0000427_abnormal_hair_cycle0.92370533
96MP0005253_abnormal_eye_physiology0.91973651
97MP0000516_abnormal_urinary_system0.91648762
98MP0005367_renal/urinary_system_phenotyp0.91648762
99MP0005391_vision/eye_phenotype0.91643968
100MP0002429_abnormal_blood_cell0.90932678
101MP0002075_abnormal_coat/hair_pigmentati0.90552337
102MP0002282_abnormal_trachea_morphology0.90037911
103MP0004142_abnormal_muscle_tone0.89219228
104MP0000631_abnormal_neuroendocrine_gland0.89066231
105MP0003880_abnormal_central_pattern0.88921063
106MP0002653_abnormal_ependyma_morphology0.88878851
107MP0002111_abnormal_tail_morphology0.88601792
108MP0002249_abnormal_larynx_morphology0.87732535
109MP0003283_abnormal_digestive_organ0.87606555
110MP0008872_abnormal_physiological_respon0.85899666
111MP0001324_abnormal_eye_pigmentation0.85712191
112MP0000716_abnormal_immune_system0.85688845
113MP0003136_yellow_coat_color0.84599520
114MP0000579_abnormal_nail_morphology0.84513736
115MP0001186_pigmentation_phenotype0.84084551
116MP0001873_stomach_inflammation0.83161073
117MP0001145_abnormal_male_reproductive0.83139167
118MP0000569_abnormal_digit_pigmentation0.82669643
119MP0002160_abnormal_reproductive_system0.82662516
120MP0010155_abnormal_intestine_physiology0.82137896
121MP0002697_abnormal_eye_size0.81673645
122MP0003950_abnormal_plasma_membrane0.80708087
123MP0003123_paternal_imprinting0.80530210
124MP0002837_dystrophic_cardiac_calcinosis0.79655782
125MP0005551_abnormal_eye_electrophysiolog0.78740161
126MP0003828_pulmonary_edema0.76805102
127MP0003936_abnormal_reproductive_system0.76726162
128MP0001348_abnormal_lacrimal_gland0.76697381
129MP0002736_abnormal_nociception_after0.76681306
130MP0005058_abnormal_lysosome_morphology0.75843834
131MP0002210_abnormal_sex_determination0.75108411
132MP0003943_abnormal_hepatobiliary_system0.73135203
133MP0000477_abnormal_intestine_morphology0.72786671
134MP0004147_increased_porphyrin_level0.71687521
135MP0001800_abnormal_humoral_immune0.70296572
136MP0002269_muscular_atrophy0.69772149
137MP0006276_abnormal_autonomic_nervous0.68921002
138MP0002092_abnormal_eye_morphology0.68575840
139MP0005023_abnormal_wound_healing0.68086416
140MP0000049_abnormal_middle_ear0.67401264
141MP0006082_CNS_inflammation0.67262431
142MP0000778_abnormal_nervous_system0.67177110
143MP0003221_abnormal_cardiomyocyte_apopto0.67157460
144MP0005266_abnormal_metabolism0.66047981
145MP0002163_abnormal_gland_morphology0.65725205
146MP0003195_calcinosis0.64947927
147MP0000639_abnormal_adrenal_gland0.63954586
148MP0005671_abnormal_response_to0.63653939
149MP0005195_abnormal_posterior_eye0.62163799
150MP0000653_abnormal_sex_gland0.61755499
151MP0000358_abnormal_cell_content/0.61455217
152MP0001119_abnormal_female_reproductive0.61250424
153MP0002420_abnormal_adaptive_immunity0.60613454
154MP0001835_abnormal_antigen_presentation0.60088647
155MP0001819_abnormal_immune_cell0.59497071
156MP0002932_abnormal_joint_morphology0.58532652
157MP0003941_abnormal_skin_development0.57228197

Predicted human phenotypes

RankGene SetZ-score
1Pustule (HP:0200039)5.03095460
2Poikiloderma (HP:0001029)4.54661252
3Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.35577590
4Rectal fistula (HP:0100590)4.08102952
5Rectovaginal fistula (HP:0000143)4.08102952
6Rib fusion (HP:0000902)4.07824496
7Increased IgM level (HP:0003496)4.00013075
8Tongue fasciculations (HP:0001308)3.96041353
9Facial hemangioma (HP:0000329)3.88445465
10Acute necrotizing encephalopathy (HP:0006965)3.79757281
11Intestinal fistula (HP:0100819)3.71014358
12Annular pancreas (HP:0001734)3.52893219
13Muscle fibrillation (HP:0010546)3.51559489
14Vaginal fistula (HP:0004320)3.50846566
15Acute encephalopathy (HP:0006846)3.47783887
16Patellar aplasia (HP:0006443)3.47494860
17Increased CSF lactate (HP:0002490)3.47094099
18Abnormal mitochondria in muscle tissue (HP:0008316)3.43272279
19Absent thumb (HP:0009777)3.42258981
20Mitochondrial inheritance (HP:0001427)3.41470528
21Basal cell carcinoma (HP:0002671)3.35030324
22Birth length less than 3rd percentile (HP:0003561)3.34075166
23Premature graying of hair (HP:0002216)3.33404636
24Selective tooth agenesis (HP:0001592)3.28311476
25Concave nail (HP:0001598)3.23649795
26Absent radius (HP:0003974)3.23003948
27Aplasia/Hypoplasia of the patella (HP:0006498)3.21964581
28Orthostatic hypotension (HP:0001278)3.18839279
29Squamous cell carcinoma (HP:0002860)3.16936363
30Intestinal atresia (HP:0011100)3.15248577
31Increased hepatocellular lipid droplets (HP:0006565)3.15231535
32Alopecia of scalp (HP:0002293)3.14274370
33Hepatocellular necrosis (HP:0001404)3.08579806
34Progressive macrocephaly (HP:0004481)3.06786293
35Ulnar bowing (HP:0003031)3.05407872
36Aplasia involving forearm bones (HP:0009822)3.00067847
37Absent forearm bone (HP:0003953)3.00067847
38Abnormal lung lobation (HP:0002101)2.95656835
39Aplasia/hypoplasia of the humerus (HP:0006507)2.94990574
40Volvulus (HP:0002580)2.93353143
41Abnormality of the anterior horn cell (HP:0006802)2.90011921
42Degeneration of anterior horn cells (HP:0002398)2.90011921
43Abnormality of male internal genitalia (HP:0000022)2.89148915
44Breast hypoplasia (HP:0003187)2.85226539
45Albinism (HP:0001022)2.83967243
46Meckel diverticulum (HP:0002245)2.83804500
47Increased serum lactate (HP:0002151)2.83257038
48Short humerus (HP:0005792)2.77926610
49Lipid accumulation in hepatocytes (HP:0006561)2.75894076
50Hypochromic microcytic anemia (HP:0004840)2.75209928
51Aplasia/Hypoplasia of the uvula (HP:0010293)2.74775250
52Cerebral edema (HP:0002181)2.72298316
53Hepatic necrosis (HP:0002605)2.71924689
54Vertebral hypoplasia (HP:0008417)2.71066309
55Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.71066309
56Broad alveolar ridges (HP:0000187)2.67970726
57Spinal muscular atrophy (HP:0007269)2.65064464
58Abnormal hemoglobin (HP:0011902)2.64366412
59IgA deficiency (HP:0002720)2.64162727
60Medial flaring of the eyebrow (HP:0010747)2.55990333
61Muscle fiber atrophy (HP:0100295)2.55532914
62Dysautonomia (HP:0002459)2.55455636
63Abnormality of the labia minora (HP:0012880)2.53745929
64Abnormality of the ileum (HP:0001549)2.53052492
65Abnormal number of erythroid precursors (HP:0012131)2.51843863
66Acute lymphatic leukemia (HP:0006721)2.48711112
67Abnormality of cells of the erythroid lineage (HP:0012130)2.48319698
68Reticulocytopenia (HP:0001896)2.47437728
69Abnormality of the preputium (HP:0100587)2.47000754
70Type I transferrin isoform profile (HP:0003642)2.45640156
71Carpal bone hypoplasia (HP:0001498)2.43909657
72Abnormality of chromosome stability (HP:0003220)2.42170906
73Hypoplastic pelvis (HP:0008839)2.41470979
74Abnormality of T cell physiology (HP:0011840)2.39760197
75Abnormal number of incisors (HP:0011064)2.39373699
76Increased serum pyruvate (HP:0003542)2.38065178
77IgG deficiency (HP:0004315)2.37336482
78Anteriorly placed anus (HP:0001545)2.36079780
79Molar tooth sign on MRI (HP:0002419)2.34866752
80Abnormality of midbrain morphology (HP:0002418)2.34866752
81Pancreatic cysts (HP:0001737)2.33047585
823-Methylglutaconic aciduria (HP:0003535)2.31248781
83Type 2 muscle fiber atrophy (HP:0003554)2.31026843
84Capillary hemangiomas (HP:0005306)2.30828947
85Bifid uvula (HP:0000193)2.30599265
86Pancreatic fibrosis (HP:0100732)2.29045137
87Abnormality of glycolysis (HP:0004366)2.28799930
88Lactic acidosis (HP:0003128)2.28639931
89Congenital hip dislocation (HP:0001374)2.28574640
90True hermaphroditism (HP:0010459)2.26957539
91Congenital primary aphakia (HP:0007707)2.26105965
92Hypoplasia of the radius (HP:0002984)2.25055074
93Abnormality of methionine metabolism (HP:0010901)2.24746667
94Myelodysplasia (HP:0002863)2.24743928
95Oligodactyly (HP:0012165)2.21171890
96Adrenal hypoplasia (HP:0000835)2.20441151
97Hypochromic anemia (HP:0001931)2.18229583
98Small intestinal stenosis (HP:0012848)2.18036939
99Duodenal stenosis (HP:0100867)2.18036939
100Diaphragmatic weakness (HP:0009113)2.17462204
101Premature skin wrinkling (HP:0100678)2.16262030
102Rough bone trabeculation (HP:0100670)2.15517470
103Turricephaly (HP:0000262)2.14530824
104Male infertility (HP:0003251)2.13994545
105Nephrogenic diabetes insipidus (HP:0009806)2.13911620
106Sloping forehead (HP:0000340)2.13843442
107Renal Fanconi syndrome (HP:0001994)2.13012877
108Nephronophthisis (HP:0000090)2.12090483
109Cerebral hypomyelination (HP:0006808)2.10388921
110Septo-optic dysplasia (HP:0100842)2.10011641
111Abnormality of alanine metabolism (HP:0010916)2.09698092
112Hyperalaninemia (HP:0003348)2.09698092
113Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.09698092
114Gait imbalance (HP:0002141)2.08910716
115Joint stiffness (HP:0001387)2.08312140
116Chromsome breakage (HP:0040012)2.06485032
117Stenosis of the external auditory canal (HP:0000402)2.06456576
118Horseshoe kidney (HP:0000085)2.05755686
119Lymphoma (HP:0002665)2.03836376
120Cheilitis (HP:0100825)2.03349187
121Short chin (HP:0000331)2.02971853
122Hypotelorism (HP:0000601)2.02039172
123Abnormal protein glycosylation (HP:0012346)2.00339705
124Abnormal glycosylation (HP:0012345)2.00339705
125Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.00339705
126Abnormal protein N-linked glycosylation (HP:0012347)2.00339705
127Abnormality of aspartate family amino acid metabolism (HP:0010899)1.99992042
128Ectopic kidney (HP:0000086)1.99968488
129Oligodactyly (hands) (HP:0001180)1.99742457
130Triphalangeal thumb (HP:0001199)1.98877317
131Short 5th finger (HP:0009237)1.98752611
132Short thumb (HP:0009778)1.98740616
133Abnormality of the duodenum (HP:0002246)1.98312732
134Optic disc pallor (HP:0000543)1.97428498
135Chromosomal breakage induced by crosslinking agents (HP:0003221)1.96888474
136Abnormality of T cells (HP:0002843)1.96487005
137IgM deficiency (HP:0002850)1.96194172
138Absent septum pellucidum (HP:0001331)1.95909305
139Aplasia/Hypoplasia of the tongue (HP:0010295)1.95223289
140Hyperglycinemia (HP:0002154)1.94520591
141Exertional dyspnea (HP:0002875)1.94236530
142Exercise intolerance (HP:0003546)1.94063123
143Pancreatic islet-cell hyperplasia (HP:0004510)1.93723043
144Neoplasm of the adrenal gland (HP:0100631)1.93485666
145Supernumerary spleens (HP:0009799)1.93181721
146Vaginal atresia (HP:0000148)1.92539252
147Aplastic anemia (HP:0001915)1.92215155
148Pancytopenia (HP:0001876)1.92100300
149Alacrima (HP:0000522)1.91188388
150Macrocytic anemia (HP:0001972)1.90684143
151Abnormality of the metopic suture (HP:0005556)1.90647959
152Abnormality of serum amino acid levels (HP:0003112)1.90147979
153Sclerocornea (HP:0000647)1.90021665
154Agnosia (HP:0010524)1.89482622
155Medulloblastoma (HP:0002885)1.89414036
156Methylmalonic acidemia (HP:0002912)1.88745180
157Genital tract atresia (HP:0001827)1.88291596
158Mucopolysacchariduria (HP:0008155)1.88263465
159Urinary glycosaminoglycan excretion (HP:0003541)1.88263465
160Growth hormone excess (HP:0000845)1.86449768
161Anophthalmia (HP:0000528)1.85949137
162Respiratory failure (HP:0002878)1.85635554
163Ependymoma (HP:0002888)1.84413390
164Neoplasm of the oral cavity (HP:0100649)1.83557934
165Preaxial hand polydactyly (HP:0001177)1.83347506
166Abnormality of the aortic arch (HP:0012303)1.82734193
167Lethargy (HP:0001254)1.82056224
168Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.81986893
169Gastrointestinal atresia (HP:0002589)1.81374881
170Rhabdomyosarcoma (HP:0002859)1.80412349
171Aplasia/Hypoplasia of the sacrum (HP:0008517)1.80403913
172Neoplasm of the colon (HP:0100273)1.80243590
173Hypokinesia (HP:0002375)1.79157210
174Colon cancer (HP:0003003)1.78431538
175Abnormality of the septum pellucidum (HP:0007375)1.77843853
176Vertebral fusion (HP:0002948)1.77792612
177Astrocytoma (HP:0009592)1.77767292
178Abnormality of the astrocytes (HP:0100707)1.77767292
179Bifid tongue (HP:0010297)1.76720896
180Pendular nystagmus (HP:0012043)1.76420247
181Reduced antithrombin III activity (HP:0001976)1.73477674
182Microvesicular hepatic steatosis (HP:0001414)1.72921969
183Multiple enchondromatosis (HP:0005701)1.69953039
184Optic nerve coloboma (HP:0000588)1.67634429

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK3.92076315
2MAP3K63.90140511
3MAPK153.69706558
4DDR23.55006911
5VRK23.16991716
6MST43.14991939
7MAP3K113.02473996
8PBK3.00671840
9TRIM282.85795193
10BUB12.64599643
11MATK2.58617109
12PIM22.49152370
13ZAK2.41054167
14PINK12.36775436
15DAPK12.34244083
16NUAK12.29245349
17WEE12.23153385
18CDK72.08193514
19CDC72.06810707
20YES11.99361438
21NME11.78438071
22CSK1.77784272
23PDK21.76005155
24PIM11.75044192
25FGR1.73155085
26PLK11.69916457
27BMPR1B1.66005095
28TYRO31.64955072
29WNK31.64684143
30EIF2AK11.61937844
31AKT31.58222290
32CDK61.57514433
33NME21.54034044
34UHMK11.51430440
35CHEK21.50015615
36NEK21.49490768
37DYRK1B1.47112518
38ATR1.42941857
39RPS6KB21.39165257
40SRPK11.38746363
41DYRK31.38075696
42PRKD21.36450468
43MAP3K121.36284774
44NEK11.33512001
45TSSK61.32731120
46MAP4K11.32388692
47TNIK1.29499026
48BMX1.27634722
49BCKDK1.23077901
50RPS6KC11.19221138
51RPS6KL11.19221138
52BCR1.18445650
53BRSK21.16272959
54RPS6KA61.11342559
55PDGFRA1.09379379
56ACVR1B1.09072013
57AURKB1.07930796
58EIF2AK21.05205375
59TRPM71.04742792
60ERBB31.04228534
61CDK40.99831392
62TAOK20.96505347
63MAPK110.95722488
64ERBB40.93994380
65EPHA20.93441474
66MKNK10.92101154
67MKNK20.90256608
68STK38L0.89411555
69TTK0.87020174
70EIF2AK30.83014757
71MAP3K100.81950371
72TAF10.81317796
73CDK80.80549662
74STK100.80241488
75CHEK10.79305426
76CDK20.76176085
77FGFR20.76109657
78VRK10.75568045
79CSNK2A10.73716416
80PLK20.72617827
81STK160.72054593
82SIK30.71940310
83STK240.71455918
84AURKA0.70193923
85LYN0.68871276
86CSNK1G10.68272014
87MAP4K20.66629481
88PLK40.66400880
89GRK10.65040664
90BRSK10.64446602
91RPS6KA40.64380651
92TXK0.63526360
93ATM0.62951771
94CSNK1G30.61850781
95ZAP700.61770403
96PASK0.60592419
97STK390.60407670
98GSK3A0.60167402
99CSNK2A20.59724435
100BRD40.58761879
101TESK20.58420177
102OXSR10.57995325
103FRK0.57563465
104CDK120.56493702
105MTOR0.55557690
106LATS20.55503656
107CCNB10.53472995
108RPS6KA10.52824304
109CSNK1A1L0.52103469
110ALK0.50916712
111PAK40.49956761
112FLT30.48961188
113IRAK40.48444967
114CDC42BPA0.48426052
115RPS6KB10.47799435
116IKBKB0.46975370
117FGFR10.46627518
118PLK30.46258856
119RAF10.44205027
120MAP3K40.43860125
121CDK10.43777641
122HIPK20.42085139
123STK40.42032777
124MAP3K80.41699678
125DYRK20.41385700
126TGFBR10.40612198
127TYK20.40014707
128MAP2K70.39788904
129STK30.39124364
130LCK0.38886902
131BRAF0.38385919
132TLK10.37964734
133ILK0.37772559
134CSNK1G20.37553810
135MAPKAPK20.36924536
136PRKCI0.36309123
137MYLK0.35692404
138PRKCE0.35067581
139BTK0.34881423
140PAK10.34842050
141MAPK30.34590829
142CDK190.32740848
143NLK0.32309331
144CSNK1E0.31800901
145RPS6KA50.29881855
146PAK30.28278461
147PNCK0.26974706
148ADRBK20.26180875
149LRRK20.25974783
150ARAF0.25452051
151MAP3K90.24327843

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034305.22965337
2DNA replication_Homo sapiens_hsa030305.06754939
3Base excision repair_Homo sapiens_hsa034104.34413595
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.32983509
5Spliceosome_Homo sapiens_hsa030403.05844874
6Nucleotide excision repair_Homo sapiens_hsa034202.96292172
7RNA transport_Homo sapiens_hsa030132.85721656
8Homologous recombination_Homo sapiens_hsa034402.79893431
9Ribosome_Homo sapiens_hsa030102.68228050
10Proteasome_Homo sapiens_hsa030502.52516030
11Oxidative phosphorylation_Homo sapiens_hsa001902.52254645
12Cell cycle_Homo sapiens_hsa041102.32490745
13Parkinsons disease_Homo sapiens_hsa050122.29520386
14RNA polymerase_Homo sapiens_hsa030202.21472411
15Fanconi anemia pathway_Homo sapiens_hsa034602.21022951
16Fatty acid biosynthesis_Homo sapiens_hsa000611.93261160
17mRNA surveillance pathway_Homo sapiens_hsa030151.82911793
18p53 signaling pathway_Homo sapiens_hsa041151.78254467
19Propanoate metabolism_Homo sapiens_hsa006401.74604985
20One carbon pool by folate_Homo sapiens_hsa006701.71763932
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.71582712
22Huntingtons disease_Homo sapiens_hsa050161.71249387
23Pyrimidine metabolism_Homo sapiens_hsa002401.68169077
24Primary immunodeficiency_Homo sapiens_hsa053401.59973785
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.58703185
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.54030253
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52468125
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.50048537
29Non-homologous end-joining_Homo sapiens_hsa034501.44255590
30Basal transcription factors_Homo sapiens_hsa030221.42920581
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.35820442
32RNA degradation_Homo sapiens_hsa030181.35422299
33Alzheimers disease_Homo sapiens_hsa050101.30149114
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26988487
35Fatty acid elongation_Homo sapiens_hsa000621.26784339
36Steroid biosynthesis_Homo sapiens_hsa001001.25197586
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.23951385
38Pyruvate metabolism_Homo sapiens_hsa006201.23837160
39Folate biosynthesis_Homo sapiens_hsa007901.19734055
40Biosynthesis of amino acids_Homo sapiens_hsa012301.16773799
41Notch signaling pathway_Homo sapiens_hsa043301.15041532
42Epstein-Barr virus infection_Homo sapiens_hsa051691.08578541
43Sulfur relay system_Homo sapiens_hsa041221.06702207
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.03383585
45Shigellosis_Homo sapiens_hsa051311.02625293
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.02384826
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01752771
48Herpes simplex infection_Homo sapiens_hsa051681.01456638
49Carbon metabolism_Homo sapiens_hsa012001.00434437
50Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00095572
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.99656611
52Legionellosis_Homo sapiens_hsa051340.97598436
53Circadian rhythm_Homo sapiens_hsa047100.89996026
54Oocyte meiosis_Homo sapiens_hsa041140.88339292
55Viral carcinogenesis_Homo sapiens_hsa052030.86802917
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.85549487
57mTOR signaling pathway_Homo sapiens_hsa041500.85322283
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.85019305
59Hippo signaling pathway_Homo sapiens_hsa043900.84874955
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83131260
61Fructose and mannose metabolism_Homo sapiens_hsa000510.80779068
62Antigen processing and presentation_Homo sapiens_hsa046120.79268240
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79151419
64Arginine and proline metabolism_Homo sapiens_hsa003300.77734067
65Peroxisome_Homo sapiens_hsa041460.75531302
66Butanoate metabolism_Homo sapiens_hsa006500.73682352
67Measles_Homo sapiens_hsa051620.71380120
68Hedgehog signaling pathway_Homo sapiens_hsa043400.69645329
69Metabolic pathways_Homo sapiens_hsa011000.68375143
70Adherens junction_Homo sapiens_hsa045200.66412295
71Purine metabolism_Homo sapiens_hsa002300.66170634
72Phototransduction_Homo sapiens_hsa047440.61960578
73Cardiac muscle contraction_Homo sapiens_hsa042600.61773435
74Bladder cancer_Homo sapiens_hsa052190.58784034
75Sulfur metabolism_Homo sapiens_hsa009200.58094904
76HTLV-I infection_Homo sapiens_hsa051660.57881716
77TGF-beta signaling pathway_Homo sapiens_hsa043500.57371264
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57204476
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54175276
80Colorectal cancer_Homo sapiens_hsa052100.53938018
81Small cell lung cancer_Homo sapiens_hsa052220.52104452
82Thyroid cancer_Homo sapiens_hsa052160.51899451
83Galactose metabolism_Homo sapiens_hsa000520.51192025
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.50822011
85MicroRNAs in cancer_Homo sapiens_hsa052060.49606094
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47534006
87Hepatitis B_Homo sapiens_hsa051610.47231256
88Viral myocarditis_Homo sapiens_hsa054160.46281733
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45811090
90Acute myeloid leukemia_Homo sapiens_hsa052210.43856713
91Regulation of autophagy_Homo sapiens_hsa041400.43611104
92Chronic myeloid leukemia_Homo sapiens_hsa052200.43539610
93Tryptophan metabolism_Homo sapiens_hsa003800.41276194
94beta-Alanine metabolism_Homo sapiens_hsa004100.41011699
95Pentose phosphate pathway_Homo sapiens_hsa000300.40982304
96Apoptosis_Homo sapiens_hsa042100.40710579
97Nitrogen metabolism_Homo sapiens_hsa009100.40603508
98Intestinal immune network for IgA production_Homo sapiens_hsa046720.39289275
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37686996
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.37394414
101Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37341254
102Vitamin B6 metabolism_Homo sapiens_hsa007500.37058347
103NF-kappa B signaling pathway_Homo sapiens_hsa040640.36969986
104Glutathione metabolism_Homo sapiens_hsa004800.36897469
105N-Glycan biosynthesis_Homo sapiens_hsa005100.36774452
106Drug metabolism - other enzymes_Homo sapiens_hsa009830.36637849
107Basal cell carcinoma_Homo sapiens_hsa052170.35939089
108Lysine degradation_Homo sapiens_hsa003100.35588010
109Wnt signaling pathway_Homo sapiens_hsa043100.35162797
110Glycosaminoglycan degradation_Homo sapiens_hsa005310.33881202
111Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33866508
112Selenocompound metabolism_Homo sapiens_hsa004500.32144548
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31438948
114Caffeine metabolism_Homo sapiens_hsa002320.31432713
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30107056
116B cell receptor signaling pathway_Homo sapiens_hsa046620.28879516
117Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28701706
118Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.27015821
119Systemic lupus erythematosus_Homo sapiens_hsa053220.26411702
120Fatty acid metabolism_Homo sapiens_hsa012120.25806625
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24911811
122SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24508655
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.23787616
124Maturity onset diabetes of the young_Homo sapiens_hsa049500.23686855
125Primary bile acid biosynthesis_Homo sapiens_hsa001200.22539014
126VEGF signaling pathway_Homo sapiens_hsa043700.22191833
127Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.20407859
128Protein export_Homo sapiens_hsa030600.20241561
129Fatty acid degradation_Homo sapiens_hsa000710.20155406
130Hematopoietic cell lineage_Homo sapiens_hsa046400.19331277
131Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.19321940
132Cyanoamino acid metabolism_Homo sapiens_hsa004600.18949952
133Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.18823925
134Pentose and glucuronate interconversions_Homo sapiens_hsa000400.18741604
135HIF-1 signaling pathway_Homo sapiens_hsa040660.18333579
136Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.18333261
137Regulation of actin cytoskeleton_Homo sapiens_hsa048100.16881320
138Allograft rejection_Homo sapiens_hsa053300.16630534
139Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.15501562
140Chemical carcinogenesis_Homo sapiens_hsa052040.14896569
141Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.14136502
142Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.11454978
143Retinol metabolism_Homo sapiens_hsa008300.11131925
144Vibrio cholerae infection_Homo sapiens_hsa051100.09183515
145Olfactory transduction_Homo sapiens_hsa047400.08669440

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