ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.49839868
2	water-soluble vitamin biosynthetic process (GO:0042364)	4.65268309
3	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.45270660
4	DNA ligation (GO:0006266)	4.39538860
5	respiratory chain complex IV assembly (GO:0008535)	4.19590567
6	maturation of 5.8S rRNA (GO:0000460)	3.94500161
7	negative regulation of acute inflammatory response (GO:0002674)	3.93770388
8	piRNA metabolic process (GO:0034587)	3.92822584
9	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.71861080
10	cytochrome complex assembly (GO:0017004)	3.69393039
11	protein complex biogenesis (GO:0070271)	3.57537119
12	isotype switching (GO:0045190)	3.54870734
13	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.54870734
14	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.54870734
15	regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)	3.52397709
16	platelet dense granule organization (GO:0060155)	3.49698284
17	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.47777626
18	synapsis (GO:0007129)	3.39215930
19	mitochondrial respiratory chain complex assembly (GO:0033108)	3.36426002
20	positive regulation of mitochondrial fission (GO:0090141)	3.33450879
21	fucose catabolic process (GO:0019317)	3.31542213
22	L-fucose metabolic process (GO:0042354)	3.31542213
23	L-fucose catabolic process (GO:0042355)	3.31542213
24	regulation of glucokinase activity (GO:0033131)	3.26875868
25	regulation of hexokinase activity (GO:1903299)	3.26875868
26	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.20240721
27	chaperone-mediated protein transport (GO:0072321)	3.19776556
28	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.18907583
29	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.17256663
30	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.17256663
31	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	3.15924374
32	adaptation of signaling pathway (GO:0023058)	3.15678702
33	single strand break repair (GO:0000012)	3.14317440
34	cytokine production involved in immune response (GO:0002367)	3.13626132
35	adult feeding behavior (GO:0008343)	3.11391527
36	regulation of immunoglobulin secretion (GO:0051023)	3.10178904
37	regulation of cellular amino acid metabolic process (GO:0006521)	3.08451087
38	regulation of isotype switching to IgG isotypes (GO:0048302)	3.08423593
39	protein polyglutamylation (GO:0018095)	3.05881839
40	organelle disassembly (GO:1903008)	3.03548065
41	rRNA modification (GO:0000154)	3.01179559
42	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.00974989
43	NADH dehydrogenase complex assembly (GO:0010257)	3.00974989
44	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.00974989
45	positive regulation of granulocyte differentiation (GO:0030854)	2.99180834
46	DNA methylation involved in gamete generation (GO:0043046)	2.99060434
47	regulation of interleukin-6 biosynthetic process (GO:0045408)	2.96540803
48	regulation of mitochondrial translation (GO:0070129)	2.93372703
49	magnesium ion transport (GO:0015693)	2.93331390
50	T cell differentiation involved in immune response (GO:0002292)	2.93120292
51	alpha-beta T cell differentiation involved in immune response (GO:0002293)	2.93120292
52	alpha-beta T cell activation involved in immune response (GO:0002287)	2.93120292
53	protein K6-linked ubiquitination (GO:0085020)	2.88336213
54	rRNA methylation (GO:0031167)	2.87938959
55	regulation of chronic inflammatory response (GO:0002676)	2.84623097
56	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.83133145
57	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.82931177
58	production of molecular mediator of immune response (GO:0002440)	2.80556664
59	tryptophan metabolic process (GO:0006568)	2.80341351
60	indolalkylamine metabolic process (GO:0006586)	2.77917007
61	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.76932516
62	indole-containing compound catabolic process (GO:0042436)	2.75022803
63	indolalkylamine catabolic process (GO:0046218)	2.75022803
64	tryptophan catabolic process (GO:0006569)	2.75022803
65	regulation of MHC class II biosynthetic process (GO:0045346)	2.74566736
66	negative regulation of heart rate (GO:0010459)	2.74537088
67	intracellular protein transmembrane import (GO:0044743)	2.72667905
68	behavioral response to nicotine (GO:0035095)	2.72144429
69	kinetochore assembly (GO:0051382)	2.71363191
70	proteasome assembly (GO:0043248)	2.70138287
71	ribonucleoprotein complex disassembly (GO:0032988)	2.69782589
72	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.69512911
73	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.69512911
74	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.69512911
75	positive regulation of organelle assembly (GO:1902117)	2.67702553
76	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.66597372
77	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.65954972
78	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.65954972
79	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.63383281
80	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.62192409
81	GTP biosynthetic process (GO:0006183)	2.58376150
82	rRNA catabolic process (GO:0016075)	2.57408906
83	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.56159634
84	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)	2.55918533
85	hindbrain development (GO:0030902)	2.55372956
86	positive regulation of gastrulation (GO:2000543)	2.55061760
87	polyketide metabolic process (GO:0030638)	2.54895544
88	doxorubicin metabolic process (GO:0044598)	2.54895544
89	daunorubicin metabolic process (GO:0044597)	2.54895544
90	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.52837939
91	negative regulation of ligase activity (GO:0051352)	2.52837939
92	signal peptide processing (GO:0006465)	2.52571486
93	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.51730736
94	negative regulation of meiotic cell cycle (GO:0051447)	2.50982730
95	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.50512373
96	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.50512373
97	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.49955233
98	auditory receptor cell stereocilium organization (GO:0060088)	2.47970733
99	phosphatidylcholine acyl-chain remodeling (GO:0036151)	2.47239088
100	T-helper cell differentiation (GO:0042093)	2.44709008

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.05833085
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.81201051
3	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.47056891
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.43628255
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.10835068
6	VDR_22108803_ChIP-Seq_LS180_Human	3.03804402
7	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.93206814
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.87464539
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.84687603
10	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.79728044
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.68829794
12	IRF1_19129219_ChIP-ChIP_H3396_Human	2.54689067
13	EWS_26573619_Chip-Seq_HEK293_Human	2.41821555
14	TAF15_26573619_Chip-Seq_HEK293_Human	2.32244077
15	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.24243064
16	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.22438239
17	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.17560141
18	VDR_23849224_ChIP-Seq_CD4+_Human	2.17425759
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.03049050
20	GBX2_23144817_ChIP-Seq_PC3_Human	1.95061391
21	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.92980211
22	ELK1_19687146_ChIP-ChIP_HELA_Human	1.86796088
23	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.84769414
24	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.84655665
25	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.79542029
26	MYC_18940864_ChIP-ChIP_HL60_Human	1.77189269
27	FOXP3_21729870_ChIP-Seq_TREG_Human	1.74719212
28	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.74595080
29	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.73132124
30	P300_19829295_ChIP-Seq_ESCs_Human	1.70893097
31	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.70014334
32	ER_23166858_ChIP-Seq_MCF-7_Human	1.67663435
33	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.65393881
34	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.63376370
35	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.62810246
36	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.61053967
37	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.59090490
38	HTT_18923047_ChIP-ChIP_STHdh_Human	1.58946975
39	FUS_26573619_Chip-Seq_HEK293_Human	1.56891965
40	TP53_22573176_ChIP-Seq_HFKS_Human	1.55945662
41	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.52636381
42	EZH2_22144423_ChIP-Seq_EOC_Human	1.50611702
43	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.48960901
44	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.43017378
45	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.42610807
46	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.36907625
47	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.35890779
48	NANOG_19829295_ChIP-Seq_ESCs_Human	1.33903465
49	SOX2_19829295_ChIP-Seq_ESCs_Human	1.33903465
50	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.31786319
51	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.31786319
52	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.25247961
53	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.23287146
54	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.20726165
55	NCOR_22424771_ChIP-Seq_293T_Human	1.20574894
56	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.18699318
57	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.18411522
58	AR_20517297_ChIP-Seq_VCAP_Human	1.17668286
59	CBP_20019798_ChIP-Seq_JUKART_Human	1.15980927
60	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.15980927
61	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.15391920
62	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.15373591
63	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.15073313
64	GATA3_26560356_Chip-Seq_TH2_Human	1.13825451
65	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.13070633
66	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.11465413
67	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.09794375
68	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.09715133
69	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.08282225
70	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.07433940
71	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.04281357
72	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.02552377
73	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.02220210
74	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.01949776
75	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.01153447
76	AR_25329375_ChIP-Seq_VCAP_Human	1.00484955
77	RNF2_27304074_Chip-Seq_NSC_Mouse	0.98060537
78	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.97665255
79	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.97500613
80	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.96868288
81	TCF4_22108803_ChIP-Seq_LS180_Human	0.96614778
82	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.93783130
83	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.93648792
84	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.93185127
85	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.91483290
86	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.91444853
87	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.91122496
88	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.90903735
89	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.90416537
90	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.89324630
91	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.88442546
92	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.87903529
93	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.87281375
94	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.87063101
95	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.86240795
96	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.85969211
97	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.85862212
98	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.85832224
99	HOXB7_26014856_ChIP-Seq_BT474_Human	0.84918370
100	RUNX2_22187159_ChIP-Seq_PCA_Human	0.84691078

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003011_delayed_dark_adaptation	3.24736586
2	MP0008872_abnormal_physiological_respon	3.05303792
3	MP0006276_abnormal_autonomic_nervous	2.80288320
4	MP0008875_abnormal_xenobiotic_pharmacok	2.65738115
5	MP0001348_abnormal_lacrimal_gland	2.63910067
6	MP0002102_abnormal_ear_morphology	2.57711875
7	MP0001873_stomach_inflammation	2.52809552
8	MP0002876_abnormal_thyroid_physiology	2.48785343
9	MP0001986_abnormal_taste_sensitivity	2.42200815
10	MP0006072_abnormal_retinal_apoptosis	2.31012804
11	MP0002160_abnormal_reproductive_system	2.24557255
12	MP0002837_dystrophic_cardiac_calcinosis	2.16912031
13	MP0008877_abnormal_DNA_methylation	2.13711961
14	MP0001529_abnormal_vocalization	2.07478325
15	MP0005646_abnormal_pituitary_gland	1.98789455
16	MP0001835_abnormal_antigen_presentation	1.96496994
17	MP0005084_abnormal_gallbladder_morpholo	1.94025909
18	MP0005389_reproductive_system_phenotype	1.93638782
19	MP0002254_reproductive_system_inflammat	1.93284480
20	MP0002693_abnormal_pancreas_physiology	1.90036568
21	MP0000427_abnormal_hair_cycle	1.79431269
22	MP0005551_abnormal_eye_electrophysiolog	1.78613418
23	MP0003787_abnormal_imprinting	1.77806313
24	MP0003880_abnormal_central_pattern	1.77114893
25	MP0005671_abnormal_response_to	1.74508139
26	MP0005253_abnormal_eye_physiology	1.69976636
27	MP0009780_abnormal_chondrocyte_physiolo	1.68974553
28	MP0003724_increased_susceptibility_to	1.66650679
29	MP0001919_abnormal_reproductive_system	1.62648794
30	MP0001984_abnormal_olfaction	1.59634375
31	MP0003195_calcinosis	1.56812750
32	MP0009379_abnormal_foot_pigmentation	1.54125467
33	MP0003283_abnormal_digestive_organ	1.53646985
34	MP0005410_abnormal_fertilization	1.44598000
35	MP0003786_premature_aging	1.42494418
36	MP0009046_muscle_twitch	1.34443983
37	MP0006082_CNS_inflammation	1.30882001
38	MP0006036_abnormal_mitochondrial_physio	1.30176766
39	MP0009697_abnormal_copulation	1.30066425
40	MP0002234_abnormal_pharynx_morphology	1.28372877
41	MP0003806_abnormal_nucleotide_metabolis	1.28333719
42	MP0001663_abnormal_digestive_system	1.27722084
43	MP0002272_abnormal_nervous_system	1.26778796
44	MP0008995_early_reproductive_senescence	1.24611465
45	MP0005645_abnormal_hypothalamus_physiol	1.20245164
46	MP0008058_abnormal_DNA_repair	1.19606315
47	MP0003303_peritoneal_inflammation	1.19431349
48	MP0000569_abnormal_digit_pigmentation	1.19038753
49	MP0004142_abnormal_muscle_tone	1.15386382
50	MP0004145_abnormal_muscle_electrophysio	1.12597557
51	MP0002822_catalepsy	1.11010751
52	MP0001968_abnormal_touch/_nociception	1.07937355
53	MP0009785_altered_susceptibility_to	1.07496073
54	MP0004133_heterotaxia	1.06739748
55	MP0000372_irregular_coat_pigmentation	1.02390659
56	MP0001944_abnormal_pancreas_morphology	1.01295851
57	MP0004147_increased_porphyrin_level	1.01191118
58	MP0005220_abnormal_exocrine_pancreas	1.00152261
59	MP0008775_abnormal_heart_ventricle	1.00108666
60	MP0003718_maternal_effect	0.99351088
61	MP0001764_abnormal_homeostasis	0.97885320
62	MP0003866_abnormal_defecation	0.95521162
63	MP0003186_abnormal_redox_activity	0.94712703
64	MP0005075_abnormal_melanosome_morpholog	0.94390172
65	MP0002751_abnormal_autonomic_nervous	0.94243727
66	MP0002277_abnormal_respiratory_mucosa	0.93496251
67	MP0003646_muscle_fatigue	0.92621282
68	MP0002638_abnormal_pupillary_reflex	0.91754112
69	MP0002148_abnormal_hypersensitivity_rea	0.91503728
70	MP0008961_abnormal_basal_metabolism	0.91452421
71	MP0002557_abnormal_social/conspecific_i	0.91202177
72	MP0001905_abnormal_dopamine_level	0.90963309
73	MP0005381_digestive/alimentary_phenotyp	0.90573116
74	MP0002736_abnormal_nociception_after	0.90051877
75	MP0001502_abnormal_circadian_rhythm	0.89672121
76	MP0005379_endocrine/exocrine_gland_phen	0.85891064
77	MP0001188_hyperpigmentation	0.85853972
78	MP0010386_abnormal_urinary_bladder	0.85335149
79	MP0009745_abnormal_behavioral_response	0.82567464
80	MP0001800_abnormal_humoral_immune	0.82522748
81	MP0004084_abnormal_cardiac_muscle	0.81307233
82	MP0008004_abnormal_stomach_pH	0.80526755
83	MP0003137_abnormal_impulse_conducting	0.80226922
84	MP0003890_abnormal_embryonic-extraembry	0.79645650
85	MP0000685_abnormal_immune_system	0.79386216
86	MP0002653_abnormal_ependyma_morphology	0.79144627
87	MP0005387_immune_system_phenotype	0.77700356
88	MP0001790_abnormal_immune_system	0.77700356
89	MP0003119_abnormal_digestive_system	0.77118904
90	MP0000013_abnormal_adipose_tissue	0.76328368
91	MP0005000_abnormal_immune_tolerance	0.74765888
92	MP0006292_abnormal_olfactory_placode	0.74306191
93	MP0004742_abnormal_vestibular_system	0.74081589
94	MP0002733_abnormal_thermal_nociception	0.73836820
95	MP0010094_abnormal_chromosome_stability	0.73249212
96	MP0004043_abnormal_pH_regulation	0.73204357
97	MP0004885_abnormal_endolymph	0.73158978
98	MP0005423_abnormal_somatic_nervous	0.71987164
99	MP0006035_abnormal_mitochondrial_morpho	0.71803968
100	MP0005167_abnormal_blood-brain_barrier	0.70328637

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.40859157
2	Hypothermia (HP:0002045)	4.06567958
3	Increased hepatocellular lipid droplets (HP:0006565)	3.76197645
4	Short tibia (HP:0005736)	3.72221310
5	Hypoglycemic coma (HP:0001325)	3.69905010
6	Pendular nystagmus (HP:0012043)	3.46442741
7	Renal cortical cysts (HP:0000803)	3.45857148
8	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.42682199
9	Lipid accumulation in hepatocytes (HP:0006561)	3.33542975
10	Abnormal rod and cone electroretinograms (HP:0008323)	3.33321067
11	Progressive inability to walk (HP:0002505)	3.11532960
12	Type II lissencephaly (HP:0007260)	3.09536112
13	Ketoacidosis (HP:0001993)	3.07305484
14	Hyperinsulinemic hypoglycemia (HP:0000825)	3.05441198
15	Methylmalonic acidemia (HP:0002912)	3.00560239
16	Type 2 muscle fiber atrophy (HP:0003554)	2.99791099
17	Increased CSF lactate (HP:0002490)	2.95509759
18	Hypomagnesemia (HP:0002917)	2.87322306
19	Inability to walk (HP:0002540)	2.87010849
20	Gonadal dysgenesis (HP:0000133)	2.85143334
21	Facial diplegia (HP:0001349)	2.82180081
22	Mitochondrial inheritance (HP:0001427)	2.72823528
23	Hypoglycemic seizures (HP:0002173)	2.70076957
24	Hepatic necrosis (HP:0002605)	2.68950058
25	Abnormality of the renal cortex (HP:0011035)	2.67035192
26	Attenuation of retinal blood vessels (HP:0007843)	2.65635814
27	Disproportionate short-trunk short stature (HP:0003521)	2.65298654
28	Colon cancer (HP:0003003)	2.64774908
29	Acute necrotizing encephalopathy (HP:0006965)	2.59838996
30	Large for gestational age (HP:0001520)	2.59251274
31	Abnormality of the prostate (HP:0008775)	2.59174836
32	Abnormality of alanine metabolism (HP:0010916)	2.57740227
33	Hyperalaninemia (HP:0003348)	2.57740227
34	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.57740227
35	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.52362691
36	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.52362691
37	Glycosuria (HP:0003076)	2.52304903
38	Abnormality of urine glucose concentration (HP:0011016)	2.52304903
39	Congenital stationary night blindness (HP:0007642)	2.51056219
40	Retinal dysplasia (HP:0007973)	2.50790616
41	Exertional dyspnea (HP:0002875)	2.47274202
42	Acute encephalopathy (HP:0006846)	2.46293942
43	Muscle fiber atrophy (HP:0100295)	2.45812720
44	Abolished electroretinogram (ERG) (HP:0000550)	2.43970485
45	Cerebellar dysplasia (HP:0007033)	2.43230951
46	Molar tooth sign on MRI (HP:0002419)	2.41555526
47	Abnormality of midbrain morphology (HP:0002418)	2.41555526
48	Abnormal albumin level (HP:0012116)	2.40597167
49	Hypoalbuminemia (HP:0003073)	2.40597167
50	Constricted visual fields (HP:0001133)	2.40231630
51	Pancreatic fibrosis (HP:0100732)	2.39184223
52	Medial flaring of the eyebrow (HP:0010747)	2.36558514
53	Ketosis (HP:0001946)	2.36123878
54	Generalized aminoaciduria (HP:0002909)	2.35912971
55	Hyperglycemia (HP:0003074)	2.34297429
56	Methylmalonic aciduria (HP:0012120)	2.34120432
57	Bony spicule pigmentary retinopathy (HP:0007737)	2.33428832
58	Renal Fanconi syndrome (HP:0001994)	2.33243082
59	Absent/shortened dynein arms (HP:0200106)	2.31159746
60	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.31159746
61	Optic disc pallor (HP:0000543)	2.27688730
62	Nephronophthisis (HP:0000090)	2.26722174
63	Lissencephaly (HP:0001339)	2.26632975
64	Atonic seizures (HP:0010819)	2.23449696
65	Hepatocellular necrosis (HP:0001404)	2.23294978
66	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.23118198
67	Gaze-evoked nystagmus (HP:0000640)	2.19892016
68	Progressive macrocephaly (HP:0004481)	2.18646169
69	Increased serum lactate (HP:0002151)	2.17449313
70	Metaphyseal dysplasia (HP:0100255)	2.16377092
71	Pancreatic cysts (HP:0001737)	2.14329645
72	Abnormal respiratory motile cilium morphology (HP:0005938)	2.12198386
73	Abnormal respiratory epithelium morphology (HP:0012253)	2.12198386
74	Hypoproteinemia (HP:0003075)	2.12067366
75	Abnormality of magnesium homeostasis (HP:0004921)	2.09274970
76	Stomatitis (HP:0010280)	2.09113289
77	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.09066653
78	Lactic acidosis (HP:0003128)	2.07440175
79	Abnormal mitochondria in muscle tissue (HP:0008316)	2.05532355
80	Bile duct proliferation (HP:0001408)	1.97750764
81	Abnormal biliary tract physiology (HP:0012439)	1.97750764
82	Progressive microcephaly (HP:0000253)	1.96280127
83	Increased intramyocellular lipid droplets (HP:0012240)	1.94769834
84	Polyuria (HP:0000103)	1.91352804
85	IgG deficiency (HP:0004315)	1.88062698
86	True hermaphroditism (HP:0010459)	1.88052707
87	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.87729994
88	Dicarboxylic aciduria (HP:0003215)	1.87729994
89	Pachygyria (HP:0001302)	1.85042536
90	Hyperglycinemia (HP:0002154)	1.84339487
91	3-Methylglutaconic aciduria (HP:0003535)	1.84160635
92	Prostate neoplasm (HP:0100787)	1.80449947
93	Symptomatic seizures (HP:0011145)	1.79592934
94	Abnormality of the labia minora (HP:0012880)	1.77876593
95	Abnormality of vitamin B metabolism (HP:0004340)	1.77826766
96	Severe combined immunodeficiency (HP:0004430)	1.77327019
97	Prominent metopic ridge (HP:0005487)	1.76928369
98	Chronic hepatic failure (HP:0100626)	1.76665099
99	Delayed CNS myelination (HP:0002188)	1.76302285
100	Chorioretinal atrophy (HP:0000533)	1.76267216

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.18991900
2	TIE1	2.90129810
3	MKNK1	2.81595221
4	NUAK1	2.71014347
5	TNK2	2.54548536
6	STK16	2.47013646
7	EIF2AK3	2.45129558
8	INSRR	2.41930183
9	TLK1	2.28051183
10	PBK	2.20125208
11	ZAK	2.18671547
12	TNIK	2.02555257
13	WNK4	1.95655359
14	WNK3	1.82266136
15	BMPR2	1.78176504
16	ADRBK2	1.73416089
17	MAPKAPK5	1.68511440
18	BMPR1B	1.68379798
19	GRK1	1.64934681
20	FRK	1.62995959
21	TRIM28	1.62310875
22	TXK	1.61313111
23	BUB1	1.59504475
24	BRD4	1.55551869
25	PLK4	1.49126335
26	DAPK2	1.48064776
27	VRK2	1.46972159
28	PINK1	1.44235428
29	PLK3	1.35529453
30	STK38L	1.34922382
31	VRK1	1.28458642
32	NEK1	1.25627786
33	TEC	1.25325389
34	MAP3K12	1.19663244
35	CSNK1G3	1.16607750
36	TSSK6	1.15215175
37	CDK8	1.14546061
38	MAP2K7	1.05714554
39	MAP3K4	1.02308005
40	PASK	1.02290641
41	ERBB3	0.99782271
42	CSNK1G2	0.98333844
43	SRPK1	0.96403438
44	RPS6KA5	0.92444018
45	ITK	0.92035981
46	FLT3	0.91989085
47	RIPK4	0.90172115
48	EIF2AK1	0.89314271
49	ACVR1B	0.87677614
50	CSNK1A1L	0.85971538
51	CSNK1G1	0.85672876
52	PAK3	0.83558037
53	PHKG1	0.83514535
54	PHKG2	0.83514535
55	OXSR1	0.83112868
56	STK24	0.82592289
57	CAMKK2	0.81927786
58	MAPK13	0.81664417
59	PRKCQ	0.76571203
60	FER	0.75059782
61	DYRK2	0.74204059
62	TAOK3	0.73247959
63	STK4	0.70663748
64	ADRBK1	0.69022508
65	MINK1	0.66659620
66	MYLK	0.65923494
67	EPHA3	0.64589918
68	BRSK2	0.64393100
69	BTK	0.60609985
70	SCYL2	0.59970429
71	KDR	0.59247464
72	DAPK1	0.58656227
73	LIMK1	0.58295848
74	DYRK3	0.57249479
75	PLK1	0.53434518
76	BCR	0.53197938
77	MARK1	0.52244612
78	CSNK1A1	0.48065218
79	PRKCE	0.46598124
80	CSF1R	0.46272907
81	STK3	0.45761005
82	MKNK2	0.44503995
83	SIK3	0.44466275
84	SYK	0.43701783
85	KIT	0.43624817
86	BCKDK	0.43444843
87	STK39	0.41224359
88	AKT3	0.40691426
89	MAP2K6	0.40452137
90	TESK2	0.38777476
91	PLK2	0.38555222
92	IKBKB	0.38080302
93	ALK	0.37638196
94	MST4	0.35310973
95	NME1	0.35265171
96	PRKCI	0.34055473
97	NTRK3	0.33376120
98	NLK	0.32838910
99	PRKCG	0.32690824
100	FES	0.31316881

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.68955714
2	Asthma_Homo sapiens_hsa05310	3.41482928
3	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.30545998
4	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.18429979
5	Protein export_Homo sapiens_hsa03060	3.10494422
6	Allograft rejection_Homo sapiens_hsa05330	2.85455892
7	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.77838310
8	Phototransduction_Homo sapiens_hsa04744	2.67939030
9	Oxidative phosphorylation_Homo sapiens_hsa00190	2.49284202
10	Linoleic acid metabolism_Homo sapiens_hsa00591	2.19653612
11	RNA degradation_Homo sapiens_hsa03018	2.16616833
12	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.03386874
13	Basal transcription factors_Homo sapiens_hsa03022	2.00029491
14	Type I diabetes mellitus_Homo sapiens_hsa04940	1.97016745
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.87954702
16	Parkinsons disease_Homo sapiens_hsa05012	1.85122503
17	Butanoate metabolism_Homo sapiens_hsa00650	1.82438793
18	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.78696545
19	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.68612520
20	Homologous recombination_Homo sapiens_hsa03440	1.67174386
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.51152399
22	Mismatch repair_Homo sapiens_hsa03430	1.48674585
23	RNA polymerase_Homo sapiens_hsa03020	1.47851469
24	Ether lipid metabolism_Homo sapiens_hsa00565	1.46340810
25	Graft-versus-host disease_Homo sapiens_hsa05332	1.43147429
26	Collecting duct acid secretion_Homo sapiens_hsa04966	1.42551133
27	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.37190386
28	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.32520263
29	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.27417497
30	Selenocompound metabolism_Homo sapiens_hsa00450	1.26620208
31	Tryptophan metabolism_Homo sapiens_hsa00380	1.20811406
32	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.18431320
33	Non-homologous end-joining_Homo sapiens_hsa03450	1.16989682
34	Rheumatoid arthritis_Homo sapiens_hsa05323	1.16983178
35	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.14322770
36	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.11126632
37	Sulfur metabolism_Homo sapiens_hsa00920	1.10825187
38	Nucleotide excision repair_Homo sapiens_hsa03420	1.08489984
39	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.07300753
40	Fatty acid elongation_Homo sapiens_hsa00062	1.05442727
41	Regulation of autophagy_Homo sapiens_hsa04140	1.05351111
42	One carbon pool by folate_Homo sapiens_hsa00670	1.02762499
43	RNA transport_Homo sapiens_hsa03013	1.02069326
44	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.01939177
45	Propanoate metabolism_Homo sapiens_hsa00640	0.99694181
46	Huntingtons disease_Homo sapiens_hsa05016	0.97813360
47	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.97335027
48	Base excision repair_Homo sapiens_hsa03410	0.90754977
49	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.88085963
50	Peroxisome_Homo sapiens_hsa04146	0.86039062
51	DNA replication_Homo sapiens_hsa03030	0.84536568
52	Caffeine metabolism_Homo sapiens_hsa00232	0.84535626
53	Alzheimers disease_Homo sapiens_hsa05010	0.84116828
54	Primary immunodeficiency_Homo sapiens_hsa05340	0.83793976
55	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.83051916
56	Insulin secretion_Homo sapiens_hsa04911	0.82551363
57	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.77049719
58	Antigen processing and presentation_Homo sapiens_hsa04612	0.74462194
59	Ribosome_Homo sapiens_hsa03010	0.72731396
60	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.70553539
61	Taste transduction_Homo sapiens_hsa04742	0.69800396
62	Nicotine addiction_Homo sapiens_hsa05033	0.69518152
63	Pyrimidine metabolism_Homo sapiens_hsa00240	0.67813867
64	Purine metabolism_Homo sapiens_hsa00230	0.67330473
65	Serotonergic synapse_Homo sapiens_hsa04726	0.65103715
66	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.63731158
67	Retinol metabolism_Homo sapiens_hsa00830	0.63569319
68	Cardiac muscle contraction_Homo sapiens_hsa04260	0.62356348
69	Metabolic pathways_Homo sapiens_hsa01100	0.58547663
70	GABAergic synapse_Homo sapiens_hsa04727	0.53202049
71	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.50620027
72	Morphine addiction_Homo sapiens_hsa05032	0.49966174
73	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.45906579
74	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.44287200
75	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.44226977
76	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.44109512
77	Spliceosome_Homo sapiens_hsa03040	0.42678255
78	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.40854890
79	Fat digestion and absorption_Homo sapiens_hsa04975	0.39566677
80	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.39376547
81	Steroid biosynthesis_Homo sapiens_hsa00100	0.38936669
82	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.38438592
83	Nitrogen metabolism_Homo sapiens_hsa00910	0.37351076
84	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.36754407
85	Viral myocarditis_Homo sapiens_hsa05416	0.36157724
86	Olfactory transduction_Homo sapiens_hsa04740	0.35617773
87	Circadian entrainment_Homo sapiens_hsa04713	0.30730066
88	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.30477745
89	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.29582366
90	Renin-angiotensin system_Homo sapiens_hsa04614	0.27237621
91	Long-term depression_Homo sapiens_hsa04730	0.26975105
92	Salivary secretion_Homo sapiens_hsa04970	0.25829036
93	Glutathione metabolism_Homo sapiens_hsa00480	0.25461348
94	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.25182276
95	Glutamatergic synapse_Homo sapiens_hsa04724	0.24765463
96	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.24661097
97	Oocyte meiosis_Homo sapiens_hsa04114	0.23610183
98	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.22245255
99	Legionellosis_Homo sapiens_hsa05134	0.22212161
100	p53 signaling pathway_Homo sapiens_hsa04115	0.21834338

DDX50P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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