DDX51

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.33962524
2DNA unwinding involved in DNA replication (GO:0006268)5.17940536
3ribosomal small subunit biogenesis (GO:0042274)4.71186744
4nuclear pore organization (GO:0006999)4.69776886
5nuclear pore complex assembly (GO:0051292)4.63890621
6positive regulation of CREB transcription factor activity (GO:0032793)4.52205769
7DNA strand elongation involved in DNA replication (GO:0006271)4.49796556
8DNA replication initiation (GO:0006270)4.39258399
9mitotic nuclear envelope disassembly (GO:0007077)4.34195314
10protein localization to kinetochore (GO:0034501)4.32285847
11DNA strand elongation (GO:0022616)4.28305627
12cellular response to ATP (GO:0071318)4.26577722
13folic acid-containing compound biosynthetic process (GO:0009396)4.25811697
14DNA replication checkpoint (GO:0000076)4.04747612
15nuclear envelope disassembly (GO:0051081)4.04744845
16membrane disassembly (GO:0030397)4.04744845
17formation of translation preinitiation complex (GO:0001731)4.03773021
18telomere maintenance via semi-conservative replication (GO:0032201)4.01591470
19maturation of SSU-rRNA (GO:0030490)4.01178053
20nucleobase biosynthetic process (GO:0046112)3.98857698
21tRNA modification (GO:0006400)3.96799028
22mitotic metaphase plate congression (GO:0007080)3.86479687
23protein localization to chromosome, centromeric region (GO:0071459)3.82667228
24negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.78506223
25DNA duplex unwinding (GO:0032508)3.76305173
26DNA geometric change (GO:0032392)3.73348833
27ribosome biogenesis (GO:0042254)3.72815834
28negative regulation of telomere maintenance (GO:0032205)3.71471852
29IMP biosynthetic process (GO:0006188)3.68852907
30regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.67347870
31DNA replication-dependent nucleosome organization (GO:0034723)3.63415655
32DNA replication-dependent nucleosome assembly (GO:0006335)3.63415655
33metaphase plate congression (GO:0051310)3.60526930
34pore complex assembly (GO:0046931)3.58310699
35telomere maintenance via recombination (GO:0000722)3.57785079
36purine nucleobase biosynthetic process (GO:0009113)3.57537139
37DNA deamination (GO:0045006)3.56495982
38regulation of spindle organization (GO:0090224)3.54792990
39heterochromatin organization (GO:0070828)3.52342734
40mitotic sister chromatid segregation (GO:0000070)3.51611883
41mitotic chromosome condensation (GO:0007076)3.48952016
42mitotic recombination (GO:0006312)3.45986226
43folic acid metabolic process (GO:0046655)3.43324967
44fucose catabolic process (GO:0019317)3.39918442
45L-fucose metabolic process (GO:0042354)3.39918442
46L-fucose catabolic process (GO:0042355)3.39918442
47pre-miRNA processing (GO:0031054)3.39003991
48ribosome assembly (GO:0042255)3.38078470
49telomere maintenance via telomere lengthening (GO:0010833)3.36534538
50negative regulation of RNA splicing (GO:0033119)3.34807148
51negative regulation of mRNA processing (GO:0050686)3.34745065
52meiotic chromosome segregation (GO:0045132)3.32309440
53ribonucleoprotein complex biogenesis (GO:0022613)3.29364836
54sister chromatid segregation (GO:0000819)3.27726012
55protein import into peroxisome matrix (GO:0016558)3.26340512
56mitotic sister chromatid cohesion (GO:0007064)3.25299892
57ribosomal large subunit biogenesis (GO:0042273)3.24979982
58regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.24843845
59nuclear envelope organization (GO:0006998)3.23554069
60regulation of mitotic spindle organization (GO:0060236)3.23500671
61regulation of translational fidelity (GO:0006450)3.21387358
62chromatin remodeling at centromere (GO:0031055)3.20440498
63CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.19736371
64DNA conformation change (GO:0071103)3.15811910
65nucleotide-excision repair, DNA gap filling (GO:0006297)3.15421652
66viral transcription (GO:0019083)3.14953169
67positive regulation of chromosome segregation (GO:0051984)3.14581476
68DNA replication-independent nucleosome assembly (GO:0006336)3.13985112
69DNA replication-independent nucleosome organization (GO:0034724)3.13985112
70CENP-A containing nucleosome assembly (GO:0034080)3.13743297
71positive regulation by host of viral transcription (GO:0043923)3.13680922
72* rRNA processing (GO:0006364)3.13494327
73ribosomal small subunit assembly (GO:0000028)3.13290721
74translational initiation (GO:0006413)3.13095710
75translational termination (GO:0006415)3.12817192
76tolerance induction (GO:0002507)3.09728548
77kinetochore organization (GO:0051383)3.09617103
78IMP metabolic process (GO:0046040)3.09370260
79somatic hypermutation of immunoglobulin genes (GO:0016446)3.09312477
80somatic diversification of immune receptors via somatic mutation (GO:0002566)3.09312477
81regulation of histone H3-K9 methylation (GO:0051570)3.08487684
82chromatin assembly or disassembly (GO:0006333)3.08204022
83negative regulation of DNA-templated transcription, elongation (GO:0032785)3.08135609
84establishment of chromosome localization (GO:0051303)3.06729715
85translesion synthesis (GO:0019985)3.05163649
86* rRNA metabolic process (GO:0016072)3.04584374
87negative regulation of mRNA metabolic process (GO:1903312)3.04461808
88maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.03464146
89pseudouridine synthesis (GO:0001522)2.99661034
90mitotic G1 DNA damage checkpoint (GO:0031571)2.99659615
91mannose metabolic process (GO:0006013)2.99272861
92positive regulation of histone acetylation (GO:0035066)2.98879554
93nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.97454633
94mRNA transport (GO:0051028)2.97298237
95regulation of sister chromatid cohesion (GO:0007063)2.96113919
96regulation of translational termination (GO:0006449)2.95714624
97negative regulation of histone methylation (GO:0031061)2.94515357
98spliceosomal tri-snRNP complex assembly (GO:0000244)2.93920621
99opioid receptor signaling pathway (GO:0038003)2.93897353
100base-excision repair (GO:0006284)2.93738731
101spliceosomal snRNP assembly (GO:0000387)2.93367682
102regulation of nuclear cell cycle DNA replication (GO:0033262)2.92763337
103thymic T cell selection (GO:0045061)2.92761385
104negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.92593864
105cellular response to exogenous dsRNA (GO:0071360)2.92208460
106viral mRNA export from host cell nucleus (GO:0046784)2.90934313
107regulation of chromosome segregation (GO:0051983)2.90830747
108mRNA splicing, via spliceosome (GO:0000398)2.90397286
109RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.90397286
110protein localization to chromosome (GO:0034502)2.89538424
111negative regulation of chromosome segregation (GO:0051985)2.89489597
112translational elongation (GO:0006414)2.89446028
113termination of RNA polymerase II transcription (GO:0006369)2.89376235
114RNA export from nucleus (GO:0006405)2.89361423
115RNA splicing, via transesterification reactions (GO:0000375)2.89097420
116dosage compensation (GO:0007549)2.88601684
117chromatin assembly (GO:0031497)2.88223867
118purinergic nucleotide receptor signaling pathway (GO:0035590)2.86591808
119regulation of RNA export from nucleus (GO:0046831)2.86357891
120glycine transport (GO:0015816)2.86211487
121mRNA export from nucleus (GO:0006406)2.85856613
122regulation of centrosome cycle (GO:0046605)2.84865479
123positive regulation of histone deacetylation (GO:0031065)2.84094008
124negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.83298615
125regulation of isotype switching to IgG isotypes (GO:0048302)2.83087739
126DNA alkylation (GO:0006305)2.81863189
127DNA methylation (GO:0006306)2.81863189
128cellular protein complex disassembly (GO:0043624)2.79822018
129negative regulation of telomerase activity (GO:0051974)2.79448263
130ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.76750616
131protein insertion into membrane (GO:0051205)2.75914090
132positive regulation of peptidyl-lysine acetylation (GO:2000758)2.75546399
133positive regulation of protein acetylation (GO:1901985)2.75546399
134autophagic vacuole fusion (GO:0000046)2.75214259
135positive regulation of defense response to virus by host (GO:0002230)2.74540834
136positive thymic T cell selection (GO:0045059)2.74267551
137viral life cycle (GO:0019058)2.73850583
138positive regulation of protein kinase C signaling (GO:0090037)2.71160402
139basic amino acid transport (GO:0015802)2.64353720
140negative regulation of B cell apoptotic process (GO:0002903)2.63757709
141mitochondrial RNA metabolic process (GO:0000959)2.62830074
142histone H3-K4 trimethylation (GO:0080182)2.62039925
143protein complex disassembly (GO:0043241)2.61277989
144histone H3-K4 methylation (GO:0051568)2.58951156
145tRNA methylation (GO:0030488)2.57099091
146positive regulation of triglyceride biosynthetic process (GO:0010867)2.56491845
147RNA modification (GO:0009451)2.56300398
148regulation of synapse maturation (GO:0090128)2.54490781
149regulation of hydrogen peroxide metabolic process (GO:0010310)2.54234067
150DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.53458816
151regulation of histone H3-K4 methylation (GO:0051569)2.53299445
152tRNA processing (GO:0008033)2.52915516
153response to pheromone (GO:0019236)2.51950520
154nephron tubule morphogenesis (GO:0072078)2.48630141
155nephron epithelium morphogenesis (GO:0072088)2.48630141
156histone H3-K9 methylation (GO:0051567)2.48431354
157regulation of gene silencing by RNA (GO:0060966)2.45511962
158regulation of posttranscriptional gene silencing (GO:0060147)2.45511962
159regulation of gene silencing by miRNA (GO:0060964)2.45511962
160NAD biosynthetic process (GO:0009435)2.44865650
161histone H3-K9 modification (GO:0061647)2.44092061
162cell migration in hindbrain (GO:0021535)2.42831335
163phosphatidylglycerol biosynthetic process (GO:0006655)2.41974335
164glycerophospholipid catabolic process (GO:0046475)2.41890041
165modulation by virus of host process (GO:0019054)2.40179841
166positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.39678690
167negative regulation of T cell differentiation in thymus (GO:0033085)2.39045025
168ncRNA 3-end processing (GO:0043628)2.38515337
169SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.36251281
170macromolecular complex disassembly (GO:0032984)2.35689925
171regulation of histone phosphorylation (GO:0033127)2.35578365
172regulation of histone deacetylation (GO:0031063)2.35186484
173positive regulation of synapse maturation (GO:0090129)2.35029154
174positive regulation of gene expression, epigenetic (GO:0045815)2.34679172
175negative regulation of reactive oxygen species metabolic process (GO:2000378)2.32874965
176protein targeting to ER (GO:0045047)2.30983124
177peptidyl-lysine methylation (GO:0018022)2.30474127
178DNA methylation or demethylation (GO:0044728)2.29755795
179cotranslational protein targeting to membrane (GO:0006613)2.28033884
180fucosylation (GO:0036065)2.26368134
181positive regulation of fatty acid beta-oxidation (GO:0032000)2.26279773
182rRNA catabolic process (GO:0016075)2.26236487
183snRNA transcription (GO:0009301)2.23820813
184T cell lineage commitment (GO:0002360)2.23182085

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.87307229
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.39622921
3* MYC_18555785_ChIP-Seq_MESCs_Mouse4.00327387
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.58450774
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.51994766
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.50729922
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.01563372
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.97904245
9EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.74071708
10MYC_22102868_ChIP-Seq_BL_Human2.73294084
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.67307326
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.64128068
13P68_20966046_ChIP-Seq_HELA_Human2.63792936
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.58658515
15CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.50608765
16* LXR_22292898_ChIP-Seq_THP-1_Human2.35946475
17STAT6_21828071_ChIP-Seq_BEAS2B_Human2.32520520
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.24538230
19XRN2_22483619_ChIP-Seq_HELA_Human2.19476779
20* TET1_21451524_ChIP-Seq_MESCs_Mouse2.16375751
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.11480126
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.10435028
23* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.07909538
24E2F1_21310950_ChIP-Seq_MCF-7_Human2.06909291
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.06890903
26AR_21909140_ChIP-Seq_LNCAP_Human2.06077988
27* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.97211846
28ERG_21242973_ChIP-ChIP_JURKAT_Human1.93757177
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.92788461
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.91662046
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.89087751
32KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.87877791
33PHF8_20622854_ChIP-Seq_HELA_Human1.86578033
34VDR_23849224_ChIP-Seq_CD4+_Human1.86366282
35ELF1_20517297_ChIP-Seq_JURKAT_Human1.85086901
36BCOR_27268052_Chip-Seq_Bcells_Human1.84163825
37BCL6_27268052_Chip-Seq_Bcells_Human1.83785717
38CIITA_25753668_ChIP-Seq_RAJI_Human1.83517644
39CREB1_15753290_ChIP-ChIP_HEK293T_Human1.81363285
40GABP_17652178_ChIP-ChIP_JURKAT_Human1.80628375
41* KDM2B_26808549_Chip-Seq_DND41_Human1.80230059
42E2F1_20622854_ChIP-Seq_HELA_Human1.79285084
43KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.78807575
44FOXP3_21729870_ChIP-Seq_TREG_Human1.78196802
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.74429179
46* SA1_27219007_Chip-Seq_ERYTHROID_Human1.72242795
47EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.68595582
48VDR_21846776_ChIP-Seq_THP-1_Human1.66024354
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.65926782
50GABP_19822575_ChIP-Seq_HepG2_Human1.65322242
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.65084607
52DCP1A_22483619_ChIP-Seq_HELA_Human1.64946757
53MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.64640222
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.62305012
55CTCF_27219007_Chip-Seq_Bcells_Human1.62273636
56SMC4_20622854_ChIP-Seq_HELA_Human1.59621887
57KDM5A_27292631_Chip-Seq_BREAST_Human1.58597354
58* TTF2_22483619_ChIP-Seq_HELA_Human1.57952413
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.57868569
60* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.57738889
61SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.56479954
62MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.56463363
63CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.56128009
64CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.55785738
65ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54743208
66* FOXP1_21924763_ChIP-Seq_HESCs_Human1.54044121
67OCT4_19829295_ChIP-Seq_ESCs_Human1.52539468
68ERA_21632823_ChIP-Seq_H3396_Human1.51096269
69NOTCH1_21737748_ChIP-Seq_TLL_Human1.50712897
70SA1_27219007_Chip-Seq_Bcells_Human1.50260587
71DROSHA_22980978_ChIP-Seq_HELA_Human1.49596489
72CTCF_27219007_Chip-Seq_ERYTHROID_Human1.49560372
73SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.45530849
74PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45431790
75YY1_22570637_ChIP-Seq_MALME-3M_Human1.45169713
76MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45146833
77RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.43630922
78* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.43541606
79TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.42855565
80CTCF_20526341_ChIP-Seq_ESCs_Human1.42762824
81CTCF_26484167_Chip-Seq_Bcells_Mouse1.41763201
82SRY_22984422_ChIP-ChIP_TESTIS_Rat1.41439022
83RARB_24833708_ChIP-Seq_LIVER_Mouse1.41118389
84THAP11_20581084_ChIP-Seq_MESCs_Mouse1.39187985
85KLF4_18555785_ChIP-Seq_MESCs_Mouse1.38949451
86CREB1_26743006_Chip-Seq_LNCaP_Human1.38875229
87SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.38101083
88EZH2_22144423_ChIP-Seq_EOC_Human1.37705924
89RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.37502557
90* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37071353
91EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.36821538
92CTCF_21964334_ChIP-Seq_BJAB-B_Human1.36143941
93NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.35405073
94NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.34008426
95* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.32592557
96* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.31502326
97RACK7_27058665_Chip-Seq_MCF-7_Human1.31107652
98RARA_24833708_ChIP-Seq_LIVER_Mouse1.31060743
99VDR_24763502_ChIP-Seq_THP-1_Human1.30217666
100CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.30048354
101P300_27268052_Chip-Seq_Bcells_Human1.28537029
102ELF1_17652178_ChIP-ChIP_JURKAT_Human1.28318185
103RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.27683998
104GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26114432
105TP63_19390658_ChIP-ChIP_HaCaT_Human1.25516708
106CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25254142
107SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23805022
108KDM2B_26808549_Chip-Seq_K562_Human1.23802668
109ELK3_25401928_ChIP-Seq_HUVEC_Human1.23573146
110CTCF_21964334_Chip-Seq_Bcells_Human1.22920529
111EZH2_27294783_Chip-Seq_ESCs_Mouse1.22642739
112SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.22227299
113TFEB_21752829_ChIP-Seq_HELA_Human1.21429288
114POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21347515
115ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20322264
116YY1_21170310_ChIP-Seq_MESCs_Mouse1.19422733
117FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17611007
118SUZ12_27294783_Chip-Seq_ESCs_Mouse1.17487853
119CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17281725
120TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16902036
121* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.16381099
122MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.16341151
123DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15904618
124* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15090307
125NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13983701
126* IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13134636
127CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.11349649
128SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11079024
129KDM2B_26808549_Chip-Seq_JURKAT_Human1.09884374
130RAC3_21632823_ChIP-Seq_H3396_Human1.09882074
131HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09091266
132* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.09027879
133TP53_22127205_ChIP-Seq_IMR90_Human1.07879732
134CTCF_18555785_ChIP-Seq_MESCs_Mouse1.07069185
135PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06796150
136* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.06518818
137ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06398207
138FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06271507
139* TP63_22573176_ChIP-Seq_HFKS_Human1.06174513
140SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05963484
141TCF7_22412390_ChIP-Seq_EML_Mouse1.05109954
142SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05109820
143RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.04842666
144FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04638681
145UTX_26944678_Chip-Seq_JUKART_Human1.02994068
146RXRA_24833708_ChIP-Seq_LIVER_Mouse1.02449411
147* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00784405
148KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00675352
149ELK1_19687146_ChIP-ChIP_HELA_Human0.99768044
150ZNF263_19887448_ChIP-Seq_K562_Human0.99565104
151MAF_26560356_Chip-Seq_TH1_Human0.98475100
152KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97139227
153CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95582353
154NANOG_21062744_ChIP-ChIP_HESCs_Human0.95060525
155* MYB_26560356_Chip-Seq_TH1_Human0.94908840
156E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.93373754
157SPI1_23547873_ChIP-Seq_NB4_Human0.93355225
158BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92981856
159SCL_19346495_ChIP-Seq_HPC-7_Human0.92517201
160PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90080031
161ESR1_15608294_ChIP-ChIP_MCF-7_Human0.89604790
162SOX2_18555785_ChIP-Seq_MESCs_Mouse0.88570617
163ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.88203148
164POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.87128097
165KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.84723174
166KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.84526429
167MAF_26560356_Chip-Seq_TH2_Human0.84021596
168CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.83705227
169GATA1_22383799_ChIP-Seq_G1ME_Mouse0.83423217
170MYC_18940864_ChIP-ChIP_HL60_Human0.80527319
171MYB_21317192_ChIP-Seq_ERMYB_Mouse0.80039538
172MYB_26560356_Chip-Seq_TH2_Human0.79794649

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.74548817
2MP0008057_abnormal_DNA_replication4.59428414
3MP0010094_abnormal_chromosome_stability4.26265306
4MP0003111_abnormal_nucleus_morphology4.22101825
5MP0004957_abnormal_blastocyst_morpholog3.86576998
6MP0003077_abnormal_cell_cycle3.55535421
7MP0002396_abnormal_hematopoietic_system3.08797265
8MP0008058_abnormal_DNA_repair2.92915846
9MP0010352_gastrointestinal_tract_polyps2.68431515
10MP0008007_abnormal_cellular_replicative2.57041560
11MP0001968_abnormal_touch/_nociception2.45642410
12MP0001730_embryonic_growth_arrest2.38296770
13MP0001986_abnormal_taste_sensitivity2.35909932
14MP0003136_yellow_coat_color2.33318812
15MP0000350_abnormal_cell_proliferation2.24404072
16MP0005423_abnormal_somatic_nervous2.21558320
17MP0008932_abnormal_embryonic_tissue2.20081924
18MP0010307_abnormal_tumor_latency2.06331531
19MP0009278_abnormal_bone_marrow2.02856112
20MP0001545_abnormal_hematopoietic_system2.02603739
21MP0005397_hematopoietic_system_phenotyp2.02603739
22MP0003123_paternal_imprinting2.00180656
23MP0004808_abnormal_hematopoietic_stem1.98728773
24MP0000490_abnormal_crypts_of1.98209878
25MP0005076_abnormal_cell_differentiation1.96798755
26MP0005380_embryogenesis_phenotype1.95805230
27MP0001672_abnormal_embryogenesis/_devel1.95805230
28MP0006292_abnormal_olfactory_placode1.91463894
29MP0008877_abnormal_DNA_methylation1.91244149
30MP0004381_abnormal_hair_follicle1.88853938
31MP0002653_abnormal_ependyma_morphology1.88600397
32MP0001502_abnormal_circadian_rhythm1.87509076
33MP0003984_embryonic_growth_retardation1.85146544
34MP0004742_abnormal_vestibular_system1.85117867
35MP0005174_abnormal_tail_pigmentation1.84246810
36MP0009379_abnormal_foot_pigmentation1.82905230
37MP0002249_abnormal_larynx_morphology1.82808128
38MP0008872_abnormal_physiological_respon1.81327652
39MP0002088_abnormal_embryonic_growth/wei1.81016574
40MP0001697_abnormal_embryo_size1.78420556
41MP0009745_abnormal_behavioral_response1.77544706
42MP0003787_abnormal_imprinting1.69006052
43MP0003763_abnormal_thymus_physiology1.67564328
44MP0004142_abnormal_muscle_tone1.66437146
45MP0002086_abnormal_extraembryonic_tissu1.66172391
46MP0002080_prenatal_lethality1.65612381
47MP0004130_abnormal_muscle_cell1.58999469
48MP0002085_abnormal_embryonic_tissue1.57344557
49MP0004197_abnormal_fetal_growth/weight/1.54648986
50MP0005645_abnormal_hypothalamus_physiol1.53121855
51MP0009333_abnormal_splenocyte_physiolog1.52702486
52MP0002019_abnormal_tumor_incidence1.51840203
53MP0002084_abnormal_developmental_patter1.51552898
54MP0001188_hyperpigmentation1.50603464
55MP0000313_abnormal_cell_death1.48849292
56MP0005646_abnormal_pituitary_gland1.48792332
57MP0003635_abnormal_synaptic_transmissio1.47748627
58MP0003786_premature_aging1.46781973
59MP0000703_abnormal_thymus_morphology1.45843209
60MP0002064_seizures1.45275271
61MP0004043_abnormal_pH_regulation1.40604492
62MP0002398_abnormal_bone_marrow1.40234616
63MP0003705_abnormal_hypodermis_morpholog1.36863189
64MP0001293_anophthalmia1.32913463
65MP0008995_early_reproductive_senescence1.32790132
66MP0002063_abnormal_learning/memory/cond1.32489171
67MP0001348_abnormal_lacrimal_gland1.32054630
68MP0000470_abnormal_stomach_morphology1.28854913
69MP0004859_abnormal_synaptic_plasticity1.26886858
70MP0002722_abnormal_immune_system1.26352714
71MP0002272_abnormal_nervous_system1.25536297
72MP0001919_abnormal_reproductive_system1.25131837
73MP0002735_abnormal_chemical_nociception1.24933793
74MP0003567_abnormal_fetal_cardiomyocyte1.24913093
75MP0003646_muscle_fatigue1.24331125
76MP0002572_abnormal_emotion/affect_behav1.23402256
77MP0000689_abnormal_spleen_morphology1.22954949
78MP0005551_abnormal_eye_electrophysiolog1.22581501
79MP0003121_genomic_imprinting1.20960916
80MP0003878_abnormal_ear_physiology1.17795173
81MP0005377_hearing/vestibular/ear_phenot1.17795173
82MP0002733_abnormal_thermal_nociception1.14010535
83MP0003890_abnormal_embryonic-extraembry1.13107853
84MP0002210_abnormal_sex_determination1.13054916
85MP0005671_abnormal_response_to1.12067591
86MP0002163_abnormal_gland_morphology1.11714131
87MP0001970_abnormal_pain_threshold1.10706312
88MP0004133_heterotaxia1.09085041
89MP0003283_abnormal_digestive_organ1.08900313
90MP0009046_muscle_twitch1.06849640
91MP0001663_abnormal_digestive_system1.06582396
92MP0001486_abnormal_startle_reflex1.06109948
93MP0004185_abnormal_adipocyte_glucose1.04859502
94MP0003119_abnormal_digestive_system1.02436959
95MP0002736_abnormal_nociception_after1.02261862
96MP0001145_abnormal_male_reproductive1.02232808
97MP0002638_abnormal_pupillary_reflex1.01647943
98MP0001929_abnormal_gametogenesis1.01240217
99MP0002429_abnormal_blood_cell1.00407917
100MP0002693_abnormal_pancreas_physiology1.00319470
101MP0002160_abnormal_reproductive_system0.97537464
102MP0001485_abnormal_pinna_reflex0.96521783
103MP0002557_abnormal_social/conspecific_i0.95657030
104MP0003938_abnormal_ear_development0.94587213
105MP0004885_abnormal_endolymph0.94185890
106MP0005310_abnormal_salivary_gland0.93375418
107MP0000685_abnormal_immune_system0.93361986
108MP0003436_decreased_susceptibility_to0.92248993
109MP0000716_abnormal_immune_system0.91475746
110MP0005621_abnormal_cell_physiology0.90445468
111MP0001501_abnormal_sleep_pattern0.90428990
112MP0009672_abnormal_birth_weight0.89681503
113MP0005448_abnormal_energy_balance0.89263296
114MP0000003_abnormal_adipose_tissue0.87970560
115MP0001800_abnormal_humoral_immune0.87495391
116MP0005384_cellular_phenotype0.87256343
117MP0005387_immune_system_phenotype0.86071179
118MP0001790_abnormal_immune_system0.86071179
119MP0003718_maternal_effect0.86022705
120MP0000631_abnormal_neuroendocrine_gland0.85929498
121MP0008875_abnormal_xenobiotic_pharmacok0.85350832
122MP0002405_respiratory_system_inflammati0.83661595
123MP0006035_abnormal_mitochondrial_morpho0.83242890
124MP0002132_abnormal_respiratory_system0.82904229
125MP0000678_abnormal_parathyroid_gland0.82565598
126MP0002067_abnormal_sensory_capabilities0.82553604
127MP0000653_abnormal_sex_gland0.81131551
128MP0002877_abnormal_melanocyte_morpholog0.80010789
129MP0000358_abnormal_cell_content/0.79985602
130MP0001915_intracranial_hemorrhage0.79662951
131MP0002932_abnormal_joint_morphology0.78853568
132MP0000858_altered_metastatic_potential0.78629407
133MP0005389_reproductive_system_phenotype0.78474862
134MP0005075_abnormal_melanosome_morpholog0.77712100
135MP0001346_abnormal_lacrimal_gland0.76834577
136MP0010030_abnormal_orbit_morphology0.76829354
137MP0001873_stomach_inflammation0.76630576
138MP0000733_abnormal_muscle_development0.76376065
139MP0008569_lethality_at_weaning0.75864377
140MP0001664_abnormal_digestion0.75826617
141MP0002092_abnormal_eye_morphology0.75607308
142MP0008770_decreased_survivor_rate0.75394312
143MP0000566_synostosis0.74497592
144MP0005381_digestive/alimentary_phenotyp0.74442479
145MP0010155_abnormal_intestine_physiology0.74031887
146MP0000477_abnormal_intestine_morphology0.73808529
147MP0003959_abnormal_lean_body0.72487636
148MP0003566_abnormal_cell_adhesion0.72399746
149MP0000428_abnormal_craniofacial_morphol0.71163815
150MP0001765_abnormal_ion_homeostasis0.70728544
151MP0001853_heart_inflammation0.70263789
152MP0002452_abnormal_antigen_presenting0.70240595
153MP0003303_peritoneal_inflammation0.70152714
154MP0002420_abnormal_adaptive_immunity0.69810342
155MP0001819_abnormal_immune_cell0.68416397
156MP0009053_abnormal_anal_canal0.67889470
157MP0009703_decreased_birth_body0.66892686
158MP0003941_abnormal_skin_development0.66163364
159MP0003300_gastrointestinal_ulcer0.65638948
160MP0005023_abnormal_wound_healing0.65273515
161MP0002111_abnormal_tail_morphology0.63588691
162MP0002925_abnormal_cardiovascular_devel0.62162056
163MP0000371_diluted_coat_color0.62079956
164MP0003115_abnormal_respiratory_system0.61767769
165MP0002970_abnormal_white_adipose0.61668917
166MP0002723_abnormal_immune_serum0.60827405
167MP0004264_abnormal_extraembryonic_tissu0.60247468
168MP0008961_abnormal_basal_metabolism0.59950554
169MP0002089_abnormal_postnatal_growth/wei0.58194500
170MP0002166_altered_tumor_susceptibility0.57811086
171MP0001119_abnormal_female_reproductive0.57314242
172MP0000537_abnormal_urethra_morphology0.57022862
173MP0000598_abnormal_liver_morphology0.56999903
174MP0002006_tumorigenesis0.56950184

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.14729487
2Congenital stationary night blindness (HP:0007642)3.94247127
3Selective tooth agenesis (HP:0001592)3.94046951
4Ependymoma (HP:0002888)3.79019738
5Chromsome breakage (HP:0040012)3.69875573
6Clumsiness (HP:0002312)3.66007033
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.44804325
8Testicular atrophy (HP:0000029)3.28095639
9Reticulocytopenia (HP:0001896)3.27707495
10Abnormal number of erythroid precursors (HP:0012131)3.25871225
11Medulloblastoma (HP:0002885)3.25658091
12Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.23200395
13Abnormality of cells of the erythroid lineage (HP:0012130)3.22311984
14Oral leukoplakia (HP:0002745)3.14927584
15Colon cancer (HP:0003003)3.13206064
16Basal cell carcinoma (HP:0002671)3.12582588
17Rib fusion (HP:0000902)3.09980337
18Abnormality of chromosome stability (HP:0003220)3.02199198
19Protruding tongue (HP:0010808)2.88545988
20Breast hypoplasia (HP:0003187)2.84608127
21Prominent nose (HP:0000448)2.83739820
22Myelodysplasia (HP:0002863)2.79144216
23Squamous cell carcinoma (HP:0002860)2.77767441
24Increased neuronal autofluorescent lipopigment (HP:0002074)2.75401385
25Abnormal number of incisors (HP:0011064)2.74194685
26Abnormality of midbrain morphology (HP:0002418)2.71766560
27Molar tooth sign on MRI (HP:0002419)2.71766560
28Abnormality of the preputium (HP:0100587)2.71730820
29Rough bone trabeculation (HP:0100670)2.71006016
30Rhabdomyosarcoma (HP:0002859)2.70959620
31Absent thumb (HP:0009777)2.69067217
32Meckel diverticulum (HP:0002245)2.68126561
33Patellar aplasia (HP:0006443)2.67165660
34Mesangial abnormality (HP:0001966)2.67138273
35Pendular nystagmus (HP:0012043)2.66991130
36Type II lissencephaly (HP:0007260)2.66347925
37Abnormality of the ileum (HP:0001549)2.64834362
38Attenuation of retinal blood vessels (HP:0007843)2.64328082
39Astrocytoma (HP:0009592)2.59293342
40Abnormality of the astrocytes (HP:0100707)2.59293342
41Hypoplasia of the pons (HP:0012110)2.57893929
42Aplasia/Hypoplasia of the uvula (HP:0010293)2.57037673
43Premature graying of hair (HP:0002216)2.55927460
44Concave nail (HP:0001598)2.55414627
45Poikiloderma (HP:0001029)2.53739530
46Trismus (HP:0000211)2.53379012
47Agnosia (HP:0010524)2.50410887
48Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.49695724
49Abnormality of alanine metabolism (HP:0010916)2.47720414
50Hyperalaninemia (HP:0003348)2.47720414
51Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.47720414
52Aplasia/Hypoplasia of the patella (HP:0006498)2.47485491
53High pitched voice (HP:0001620)2.47359691
54Neoplasm of striated muscle (HP:0009728)2.46604599
55Increased nuchal translucency (HP:0010880)2.45261289
56Genetic anticipation (HP:0003743)2.43714622
57Aplastic anemia (HP:0001915)2.43544892
58Ectopic kidney (HP:0000086)2.40083520
59Neoplasm of the oral cavity (HP:0100649)2.37225039
60Annular pancreas (HP:0001734)2.37054795
61Pallor (HP:0000980)2.34571722
62Bilateral microphthalmos (HP:0007633)2.34090319
63Degeneration of anterior horn cells (HP:0002398)2.32772529
64Abnormality of the anterior horn cell (HP:0006802)2.32772529
65Abnormality of the pons (HP:0007361)2.31786256
66Abnormality of the carotid arteries (HP:0005344)2.31649037
67Glioma (HP:0009733)2.31611151
68Proximal placement of thumb (HP:0009623)2.31541262
69Small intestinal stenosis (HP:0012848)2.31403228
70Duodenal stenosis (HP:0100867)2.31403228
71Neoplasm of the pancreas (HP:0002894)2.30337888
72Hypoplasia of the radius (HP:0002984)2.29775881
73IgM deficiency (HP:0002850)2.29123832
74Acute lymphatic leukemia (HP:0006721)2.28480154
75Multiple enchondromatosis (HP:0005701)2.27154878
76Partial agenesis of the corpus callosum (HP:0001338)2.25334282
77Thrombocytosis (HP:0001894)2.24584961
78Cafe-au-lait spot (HP:0000957)2.24295075
79Bone marrow hypocellularity (HP:0005528)2.22674213
80Deviation of the thumb (HP:0009603)2.22307610
81Abnormality of the fingertips (HP:0001211)2.19692610
82Lymphoma (HP:0002665)2.19292543
83Supernumerary bones of the axial skeleton (HP:0009144)2.19118125
84Impaired smooth pursuit (HP:0007772)2.17728706
85Premature ovarian failure (HP:0008209)2.16149474
86Abnormal drinking behavior (HP:0030082)2.14571249
87Polydipsia (HP:0001959)2.14571249
88Severe muscular hypotonia (HP:0006829)2.14139927
89Duplicated collecting system (HP:0000081)2.13157232
90Macrocytic anemia (HP:0001972)2.12673729
91Hyperacusis (HP:0010780)2.12092824
92Impulsivity (HP:0100710)2.08951169
93Tracheoesophageal fistula (HP:0002575)2.08724142
94Panhypogammaglobulinemia (HP:0003139)2.07861662
9511 pairs of ribs (HP:0000878)2.07572394
96Conical tooth (HP:0000698)2.07418670
97Entropion (HP:0000621)2.07111021
98Tubular atrophy (HP:0000092)2.06934818
99Long eyelashes (HP:0000527)2.06744441
100Large for gestational age (HP:0001520)2.04468334
101Amaurosis fugax (HP:0100576)2.04151556
102Absent radius (HP:0003974)2.02675249
103Optic nerve coloboma (HP:0000588)2.00042006
104Intestinal fistula (HP:0100819)1.98961768
105Missing ribs (HP:0000921)1.98683942
106Abnormality of DNA repair (HP:0003254)1.98333114
107Atresia of the external auditory canal (HP:0000413)1.98043905
108Visual hallucinations (HP:0002367)1.97839706
109Abnormal delayed hypersensitivity skin test (HP:0002963)1.97785058
110Sparse lateral eyebrow (HP:0005338)1.96797675
111Aplasia involving forearm bones (HP:0009822)1.93453664
112Absent forearm bone (HP:0003953)1.93453664
113Abnormality of the renal collecting system (HP:0004742)1.92329861
114Nephronophthisis (HP:0000090)1.92013102
115Clubbing of toes (HP:0100760)1.91839074
116Abnormality of reticulocytes (HP:0004312)1.91822652
117Broad distal phalanx of finger (HP:0009836)1.91684312
118Bony spicule pigmentary retinopathy (HP:0007737)1.90920421
119Progressive microcephaly (HP:0000253)1.90627796
120Abnormality of the labia minora (HP:0012880)1.90374465
121Skin tags (HP:0010609)1.90157471
122Sloping forehead (HP:0000340)1.89165634
123Facial hemangioma (HP:0000329)1.88694347
124Progressive muscle weakness (HP:0003323)1.88196578
125Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.87772949
126Short 4th metacarpal (HP:0010044)1.87772949
127Elfin facies (HP:0004428)1.87409183
128Abnormal trabecular bone morphology (HP:0100671)1.87177974
129Increased cerebral lipofuscin (HP:0011813)1.87155796
130Cerebral hypomyelination (HP:0006808)1.86817596
131Overlapping toe (HP:0001845)1.85716204
132Abnormality of the duodenum (HP:0002246)1.84989143
133Abnormality of the calcaneus (HP:0008364)1.84450949
134Horseshoe kidney (HP:0000085)1.84306741
135Cerebellar dysplasia (HP:0007033)1.83716522
136Abnormal spermatogenesis (HP:0008669)1.83603691
137Lissencephaly (HP:0001339)1.83549700
138Decreased electroretinogram (ERG) amplitude (HP:0000654)1.82509253
139Intellectual disability, severe (HP:0010864)1.81732103
140Overriding aorta (HP:0002623)1.81707269
141Short thumb (HP:0009778)1.81562336
142Gastrointestinal carcinoma (HP:0002672)1.80889203
143Malignant gastrointestinal tract tumors (HP:0006749)1.80889203
144Chronic mucocutaneous candidiasis (HP:0002728)1.80604115
145Recurrent cutaneous fungal infections (HP:0011370)1.80604115
146Global brain atrophy (HP:0002283)1.80305840
147Abnormality of T cell physiology (HP:0011840)1.80075608
148Renal duplication (HP:0000075)1.79386799
149Turricephaly (HP:0000262)1.79131577
150Retinal dysplasia (HP:0007973)1.79125096
151Stomatitis (HP:0010280)1.78861302
152Volvulus (HP:0002580)1.78256668
153Glossoptosis (HP:0000162)1.77773940
154Slender long bone (HP:0003100)1.77608876
155Microretrognathia (HP:0000308)1.75921710
156Spastic tetraparesis (HP:0001285)1.75910750
157Personality changes (HP:0000751)1.75828430
158Tachypnea (HP:0002789)1.75247249
159Preauricular skin tag (HP:0000384)1.74717571
160Rectovaginal fistula (HP:0000143)1.73811507
161Rectal fistula (HP:0100590)1.73811507
162Bronchomalacia (HP:0002780)1.73346678
163Progressive cerebellar ataxia (HP:0002073)1.69524060
164Short chin (HP:0000331)1.68829516
165Agammaglobulinemia (HP:0004432)1.67209410
166Obstructive sleep apnea (HP:0002870)1.66524971
167Abnormality of cochlea (HP:0000375)1.66212217
168Abnormal rod and cone electroretinograms (HP:0008323)1.65862382
169Bile duct proliferation (HP:0001408)1.65706149
170Abnormal biliary tract physiology (HP:0012439)1.65706149
171Hyperthyroidism (HP:0000836)1.61757236
172Cystic liver disease (HP:0006706)1.60940891
173IgG deficiency (HP:0004315)1.60557770
174External ophthalmoplegia (HP:0000544)1.59785523
175Pancreatic cysts (HP:0001737)1.59241639

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.97786913
2NEK23.24187718
3BUB13.04217153
4WEE12.97302055
5EEF2K2.95916466
6CDK122.82659367
7TTK2.61506080
8MAPK152.44891472
9WNK42.39163329
10MAP3K102.34528432
11SMG12.22451667
12MAP4K12.10559983
13ADRBK21.98727253
14PKN21.96132979
15ACVR1B1.94365765
16ATR1.90121387
17SRPK11.89719731
18CDK71.86037384
19TSSK61.82940176
20CDK41.79826971
21PLK11.76536160
22CAMKK11.76289516
23RPS6KA41.75142114
24EIF2AK11.73249401
25DAPK21.73217444
26TNK21.72664922
27NME21.68473196
28ICK1.68050241
29TYRO31.62380775
30IRAK41.61326387
31TRIB31.59167743
32MAP2K61.56540429
33RPS6KB21.54813451
34IRAK31.54610436
35AURKB1.44446175
36MAP2K31.43383284
37STK101.42468735
38MAP3K81.42131706
39RIPK41.42112318
40MAP2K21.38825792
41MAP3K111.38162424
42ZAK1.38110245
43DYRK31.37897314
44CHEK21.35812204
45PASK1.33224298
46ALK1.30750371
47RPS6KA61.28739970
48CHEK11.26871840
49IKBKB1.25744658
50LATS21.21795241
51STK31.21201257
52ERN11.17348185
53NEK11.17284638
54TLK11.16128668
55MKNK21.14675915
56MAP3K131.14044079
57MAPKAPK31.12120633
58PIM11.11043021
59MKNK11.09855861
60FLT31.08341569
61VRK11.07676286
62ITK1.05956953
63CDK61.04695112
64GRK11.04492506
65STK41.03215452
66MTOR1.01499444
67ATM1.00640322
68ZAP700.99983727
69CDK20.96161794
70TAOK20.95920149
71VRK20.95713107
72AURKA0.95229570
73STK110.92936180
74PAK40.91966922
75BRSK20.91736452
76BMPR1B0.90925317
77MARK20.90761963
78NME10.90682938
79BRD40.88044280
80SCYL20.87894321
81TESK20.87853552
82EPHA20.87420727
83PLK30.86173601
84PLK40.85971681
85TGFBR10.84514404
86STK160.83279368
87JAK30.82929883
88HIPK20.82158284
89RPS6KC10.82150873
90RPS6KL10.82150873
91MAP3K60.81392326
92MAPKAPK50.80780566
93GRK60.79823638
94CDC42BPA0.79681391
95TAOK30.76776613
96PRKD20.76386801
97SYK0.76266186
98MAPK120.74506577
99LRRK20.73852133
100IRAK10.71829693
101NUAK10.69441798
102MATK0.68165344
103RPS6KA20.66805037
104PIM20.65633625
105PTK60.65017550
106RPS6KA50.65016860
107TAOK10.64147836
108CDK10.63341763
109CLK10.63274579
110CSNK2A20.61397190
111CAMK1D0.61088260
112NTRK20.60282859
113PRPF4B0.60085842
114ARAF0.60055629
115FGFR20.58250301
116PHKG20.58132522
117PHKG10.58132522
118FRK0.56336944
119PAK20.56223171
120RPS6KA10.55429707
121LATS10.54870721
122BRSK10.54783399
123MAP3K50.54753330
124MAP3K30.54194049
125MAP3K90.53805751
126BTK0.53453602
127TEC0.53388334
128EIF2AK30.52023208
129CSF1R0.50756033
130CAMK10.50307523
131MAPK110.50163416
132MAP3K10.49707196
133MAPK80.49459595
134IRAK20.49384317
135PRKAA10.48473136
136PRKCH0.48153193
137PRKCQ0.46438778
138CAMK1G0.46183617
139KDR0.46096396
140MELK0.46087800
141CSNK2A10.45369002
142PDGFRA0.44520927
143PRKCI0.44467935
144MAPK130.43902964
145ADRBK10.43413841
146PRKDC0.42403959
147PDPK10.42337059
148SIK20.42066003
149PNCK0.41188315
150CSNK1E0.40849353
151PAK10.40785005
152GSK3B0.40744115
153AKT10.40739807
154KIT0.40124135
155MAP2K10.40005356
156PDK30.38428192
157PDK40.38428192
158CDK80.38245082
159SIK10.38200790
160AKT20.37637210
161RAF10.37435051
162BMX0.36806135
163CHUK0.35734874
164CSNK1D0.34676721
165TTN0.34668786

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.60161228
2Mismatch repair_Homo sapiens_hsa034304.01930458
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.82176641
4RNA transport_Homo sapiens_hsa030133.29399827
5Spliceosome_Homo sapiens_hsa030403.24311867
6Base excision repair_Homo sapiens_hsa034103.12772746
7Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.93329158
8Homologous recombination_Homo sapiens_hsa034402.89681048
9One carbon pool by folate_Homo sapiens_hsa006702.76304087
10Cell cycle_Homo sapiens_hsa041102.72040877
11Ribosome_Homo sapiens_hsa030102.53344518
12Nucleotide excision repair_Homo sapiens_hsa034202.46348048
13Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.41037741
14RNA polymerase_Homo sapiens_hsa030202.36937388
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.35377689
16Fanconi anemia pathway_Homo sapiens_hsa034602.32743685
17mRNA surveillance pathway_Homo sapiens_hsa030152.20980314
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.06222064
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.91971144
20Pyrimidine metabolism_Homo sapiens_hsa002401.91719522
21Linoleic acid metabolism_Homo sapiens_hsa005911.84706178
22Non-homologous end-joining_Homo sapiens_hsa034501.79407063
23Nicotine addiction_Homo sapiens_hsa050331.72192314
24RNA degradation_Homo sapiens_hsa030181.71501178
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.70559249
26p53 signaling pathway_Homo sapiens_hsa041151.61275409
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.57024941
28Phototransduction_Homo sapiens_hsa047441.55301475
29Proteasome_Homo sapiens_hsa030501.52268851
30Basal transcription factors_Homo sapiens_hsa030221.49668640
31Morphine addiction_Homo sapiens_hsa050321.45064170
32Nitrogen metabolism_Homo sapiens_hsa009101.44603694
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.41139290
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.36117727
35Antigen processing and presentation_Homo sapiens_hsa046121.32370109
36Epstein-Barr virus infection_Homo sapiens_hsa051691.21946968
37Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.20415060
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18389365
39Ether lipid metabolism_Homo sapiens_hsa005651.17027412
40Herpes simplex infection_Homo sapiens_hsa051681.16929304
41Viral carcinogenesis_Homo sapiens_hsa052031.12992506
42Primary immunodeficiency_Homo sapiens_hsa053401.11111244
43HTLV-I infection_Homo sapiens_hsa051661.08487239
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.04094240
45Sulfur relay system_Homo sapiens_hsa041221.03930273
46Pentose phosphate pathway_Homo sapiens_hsa000301.03911145
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.01045878
48Insulin secretion_Homo sapiens_hsa049111.00051561
49Oocyte meiosis_Homo sapiens_hsa041140.98434306
50Circadian entrainment_Homo sapiens_hsa047130.97244784
51Selenocompound metabolism_Homo sapiens_hsa004500.97074864
52Olfactory transduction_Homo sapiens_hsa047400.96991836
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96868304
54Chronic myeloid leukemia_Homo sapiens_hsa052200.96403132
55Dorso-ventral axis formation_Homo sapiens_hsa043200.96062786
56Systemic lupus erythematosus_Homo sapiens_hsa053220.94941817
57Small cell lung cancer_Homo sapiens_hsa052220.94492799
58Biosynthesis of amino acids_Homo sapiens_hsa012300.94257410
59MicroRNAs in cancer_Homo sapiens_hsa052060.93306124
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.89441746
61ABC transporters_Homo sapiens_hsa020100.87978025
62Acute myeloid leukemia_Homo sapiens_hsa052210.87954681
63Glycerophospholipid metabolism_Homo sapiens_hsa005640.87140472
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.86341307
65MAPK signaling pathway_Homo sapiens_hsa040100.83712166
66Folate biosynthesis_Homo sapiens_hsa007900.83214402
67Vitamin B6 metabolism_Homo sapiens_hsa007500.82873265
68Glutamatergic synapse_Homo sapiens_hsa047240.82136153
69Purine metabolism_Homo sapiens_hsa002300.82017542
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81813894
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.81620940
72Cholinergic synapse_Homo sapiens_hsa047250.81138775
73Calcium signaling pathway_Homo sapiens_hsa040200.79269382
74mTOR signaling pathway_Homo sapiens_hsa041500.78732867
75Ovarian steroidogenesis_Homo sapiens_hsa049130.78522021
76Lysine degradation_Homo sapiens_hsa003100.77233522
77Thyroid cancer_Homo sapiens_hsa052160.76458278
78Asthma_Homo sapiens_hsa053100.73004283
79Allograft rejection_Homo sapiens_hsa053300.72672053
80Cocaine addiction_Homo sapiens_hsa050300.72602527
81Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.72364026
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70614468
83Taste transduction_Homo sapiens_hsa047420.70175289
84Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68879759
85Hepatitis B_Homo sapiens_hsa051610.68833106
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.68583752
87B cell receptor signaling pathway_Homo sapiens_hsa046620.68365937
88Bladder cancer_Homo sapiens_hsa052190.68049228
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.67021813
90Measles_Homo sapiens_hsa051620.66668057
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63517420
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.63100137
93GnRH signaling pathway_Homo sapiens_hsa049120.61267565
94Cardiac muscle contraction_Homo sapiens_hsa042600.60702604
95Apoptosis_Homo sapiens_hsa042100.60657865
96Long-term depression_Homo sapiens_hsa047300.59897601
97Colorectal cancer_Homo sapiens_hsa052100.59818279
98Autoimmune thyroid disease_Homo sapiens_hsa053200.59258429
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58663394
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57840390
101Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57778852
102Non-small cell lung cancer_Homo sapiens_hsa052230.57778459
103Oxytocin signaling pathway_Homo sapiens_hsa049210.57292318
104Glycerolipid metabolism_Homo sapiens_hsa005610.55462479
105Legionellosis_Homo sapiens_hsa051340.54515552
106Basal cell carcinoma_Homo sapiens_hsa052170.54180813
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.53254745
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52400455
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52043286
110Gastric acid secretion_Homo sapiens_hsa049710.51970534
111Graft-versus-host disease_Homo sapiens_hsa053320.51112363
112Shigellosis_Homo sapiens_hsa051310.50875570
113Other glycan degradation_Homo sapiens_hsa005110.49963826
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49955421
115Notch signaling pathway_Homo sapiens_hsa043300.49932725
116TNF signaling pathway_Homo sapiens_hsa046680.49565511
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.48806291
118Choline metabolism in cancer_Homo sapiens_hsa052310.48153519
119T cell receptor signaling pathway_Homo sapiens_hsa046600.47992089
120Regulation of autophagy_Homo sapiens_hsa041400.47909494
121NOD-like receptor signaling pathway_Homo sapiens_hsa046210.46717232
122Amphetamine addiction_Homo sapiens_hsa050310.46508642
123Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46156803
124Serotonergic synapse_Homo sapiens_hsa047260.46081878
125Influenza A_Homo sapiens_hsa051640.44569229
126Arachidonic acid metabolism_Homo sapiens_hsa005900.43219339
127Hippo signaling pathway_Homo sapiens_hsa043900.42811566
128Maturity onset diabetes of the young_Homo sapiens_hsa049500.42547056
129HIF-1 signaling pathway_Homo sapiens_hsa040660.42084786
130GABAergic synapse_Homo sapiens_hsa047270.41625451
131Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40388926
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.39798547
133Prostate cancer_Homo sapiens_hsa052150.39118552
134Oxidative phosphorylation_Homo sapiens_hsa001900.38959173
135Viral myocarditis_Homo sapiens_hsa054160.37372816
136Endometrial cancer_Homo sapiens_hsa052130.35778438
137Pancreatic cancer_Homo sapiens_hsa052120.35428644
138Carbon metabolism_Homo sapiens_hsa012000.34613370
139Pathways in cancer_Homo sapiens_hsa052000.33948348
140TGF-beta signaling pathway_Homo sapiens_hsa043500.33280681
141VEGF signaling pathway_Homo sapiens_hsa043700.33032604
142Hematopoietic cell lineage_Homo sapiens_hsa046400.32460054
143Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32262353
144Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30388120
145Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.30159339
146Adherens junction_Homo sapiens_hsa045200.30135504
147Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29560392
148Proteoglycans in cancer_Homo sapiens_hsa052050.29056344
149N-Glycan biosynthesis_Homo sapiens_hsa005100.27478928
150Neurotrophin signaling pathway_Homo sapiens_hsa047220.25675367
151RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.25391214
152Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.25342815
153Jak-STAT signaling pathway_Homo sapiens_hsa046300.25314335
154Fructose and mannose metabolism_Homo sapiens_hsa000510.23681920
1552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.23381463
156Toxoplasmosis_Homo sapiens_hsa051450.20684468
157AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.20530632
158Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.19998302
159AMPK signaling pathway_Homo sapiens_hsa041520.19690448
160Wnt signaling pathway_Homo sapiens_hsa043100.19112807
161FoxO signaling pathway_Homo sapiens_hsa040680.18919656
162Alcoholism_Homo sapiens_hsa050340.18666389

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