DDX52

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)4.23045520
2CENP-A containing nucleosome assembly (GO:0034080)4.14867948
3maturation of SSU-rRNA (GO:0030490)4.13618007
4DNA double-strand break processing (GO:0000729)4.10140518
5ribosomal small subunit assembly (GO:0000028)4.08358066
6chromatin remodeling at centromere (GO:0031055)4.06542459
7purine nucleobase biosynthetic process (GO:0009113)3.99273986
8protein localization to kinetochore (GO:0034501)3.99040694
9DNA replication initiation (GO:0006270)3.97203062
10nucleobase biosynthetic process (GO:0046112)3.91639118
11nuclear pore organization (GO:0006999)3.90945592
12DNA strand elongation involved in DNA replication (GO:0006271)3.88734166
13kinetochore organization (GO:0051383)3.83674766
14telomere maintenance via semi-conservative replication (GO:0032201)3.81289543
15replication fork processing (GO:0031297)3.79925165
16DNA strand elongation (GO:0022616)3.76099170
17attachment of spindle microtubules to kinetochore (GO:0008608)3.75379547
18telomere maintenance via recombination (GO:0000722)3.72806875
19DNA replication checkpoint (GO:0000076)3.72128590
20metaphase plate congression (GO:0051310)3.70147424
21ribosome assembly (GO:0042255)3.70047883
22establishment of protein localization to mitochondrial membrane (GO:0090151)3.69053702
23nuclear pore complex assembly (GO:0051292)3.66606037
24ribosomal large subunit biogenesis (GO:0042273)3.66466779
25DNA replication-independent nucleosome organization (GO:0034724)3.61279592
26DNA replication-independent nucleosome assembly (GO:0006336)3.61279592
27mitotic recombination (GO:0006312)3.59967209
28water-soluble vitamin biosynthetic process (GO:0042364)3.57063340
29regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.56860578
30regulation of mitotic spindle checkpoint (GO:1903504)3.56860578
31formation of translation preinitiation complex (GO:0001731)3.54713464
32negative regulation of DNA-dependent DNA replication (GO:2000104)3.54517275
33protein neddylation (GO:0045116)3.49437156
34regulation of spindle organization (GO:0090224)3.49310682
35mitotic nuclear envelope disassembly (GO:0007077)3.45519132
36IMP biosynthetic process (GO:0006188)3.43002319
37protein localization to chromosome, centromeric region (GO:0071459)3.41093560
38mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.40506660
39histone exchange (GO:0043486)3.37776289
40exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.37604176
41nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.36313683
42chaperone-mediated protein transport (GO:0072321)3.33377350
43establishment of chromosome localization (GO:0051303)3.32940589
44DNA unwinding involved in DNA replication (GO:0006268)3.29780233
45DNA replication-dependent nucleosome organization (GO:0034723)3.29392641
46DNA replication-dependent nucleosome assembly (GO:0006335)3.29392641
47ribosome biogenesis (GO:0042254)3.29356119
48ribonucleoprotein complex biogenesis (GO:0022613)3.28418302
49meiotic chromosome segregation (GO:0045132)3.27180047
50kinetochore assembly (GO:0051382)3.25174621
51pseudouridine synthesis (GO:0001522)3.23895263
52nucleotide-excision repair, DNA gap filling (GO:0006297)3.23324415
53regulation of nuclear cell cycle DNA replication (GO:0033262)3.22769187
54membrane disassembly (GO:0030397)3.22671955
55nuclear envelope disassembly (GO:0051081)3.22671955
56mitotic chromosome condensation (GO:0007076)3.21952262
57protein complex biogenesis (GO:0070271)3.21580776
58regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.20914361
59mitochondrial respiratory chain complex assembly (GO:0033108)3.20083477
60regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.16170060
61telomere maintenance via telomere lengthening (GO:0010833)3.15497203
62regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.14631390
63regulation of mitotic spindle organization (GO:0060236)3.14188847
64behavioral response to nicotine (GO:0035095)3.13497193
65recombinational repair (GO:0000725)3.13350330
66viral mRNA export from host cell nucleus (GO:0046784)3.11235281
67DNA damage response, detection of DNA damage (GO:0042769)3.10273640
68maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.09897053
69termination of RNA polymerase III transcription (GO:0006386)3.09609031
70transcription elongation from RNA polymerase III promoter (GO:0006385)3.09609031
71transcription-coupled nucleotide-excision repair (GO:0006283)3.09459474
72rRNA processing (GO:0006364)3.09035505
73double-strand break repair via homologous recombination (GO:0000724)3.08727745
74regulation of mitochondrial translation (GO:0070129)3.07649971
75regulation of sister chromatid cohesion (GO:0007063)3.06626298
76mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.04744317
77mitochondrial respiratory chain complex I assembly (GO:0032981)3.04744317
78NADH dehydrogenase complex assembly (GO:0010257)3.04744317
79resolution of meiotic recombination intermediates (GO:0000712)3.00202564
80IMP metabolic process (GO:0046040)3.00139592
81spindle checkpoint (GO:0031577)2.99532711
82regulation of DNA endoreduplication (GO:0032875)2.99132308
83rRNA metabolic process (GO:0016072)2.98879371
84RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.98356299
85energy coupled proton transport, down electrochemical gradient (GO:0015985)2.97558418
86ATP synthesis coupled proton transport (GO:0015986)2.97558418
87translational termination (GO:0006415)2.97221734
88mitotic sister chromatid segregation (GO:0000070)2.94668262
89somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.94322333
90isotype switching (GO:0045190)2.94322333
91somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.94322333
92regulation of chromosome segregation (GO:0051983)2.94317158
93viral transcription (GO:0019083)2.94150869
94ribosomal small subunit biogenesis (GO:0042274)2.93855409
95somatic diversification of immune receptors via somatic mutation (GO:0002566)2.93611626
96somatic hypermutation of immunoglobulin genes (GO:0016446)2.93611626
97pore complex assembly (GO:0046931)2.93494700
98positive regulation of chromosome segregation (GO:0051984)2.92861800
99spliceosomal snRNP assembly (GO:0000387)2.92518744
100mitotic sister chromatid cohesion (GO:0007064)2.92301733
101respiratory chain complex IV assembly (GO:0008535)2.91185770
102anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.87257444
103regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.87112788
104DNA catabolic process, exonucleolytic (GO:0000738)2.85683065
105negative regulation of mitotic sister chromatid separation (GO:2000816)2.85259836
106negative regulation of mitotic sister chromatid segregation (GO:0033048)2.85259836
107negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.85259836
108negative regulation of sister chromatid segregation (GO:0033046)2.85259836
109regulation of mitotic metaphase/anaphase transition (GO:0030071)2.85058295
110positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.84307088
111mitotic spindle checkpoint (GO:0071174)2.82957885
112negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.82222630
113negative regulation of chromosome segregation (GO:0051985)2.81663524
114spindle assembly checkpoint (GO:0071173)2.81387774
115telomere organization (GO:0032200)2.81274659
116histone mRNA metabolic process (GO:0008334)2.81150736
117translational initiation (GO:0006413)2.80549611
118regulation of centriole replication (GO:0046599)2.80389162
1197-methylguanosine mRNA capping (GO:0006370)2.79578330
120telomere maintenance (GO:0000723)2.79515503
1217-methylguanosine RNA capping (GO:0009452)2.78693797
122RNA capping (GO:0036260)2.78693797
123establishment of integrated proviral latency (GO:0075713)2.78181590
124regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.78108122
125transcription elongation from RNA polymerase I promoter (GO:0006362)2.78029254
126mitotic spindle assembly checkpoint (GO:0007094)2.77877258
127ncRNA catabolic process (GO:0034661)2.76692372
128folic acid-containing compound biosynthetic process (GO:0009396)2.76588549
129regulation of helicase activity (GO:0051095)2.76414019
130G1/S transition of mitotic cell cycle (GO:0000082)2.76293063
131cell cycle G1/S phase transition (GO:0044843)2.76293063
132negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.76259566
133DNA deamination (GO:0045006)2.74808972
134non-recombinational repair (GO:0000726)2.74654265
135double-strand break repair via nonhomologous end joining (GO:0006303)2.74654265
136maturation of 5.8S rRNA (GO:0000460)2.73743013
137sister chromatid segregation (GO:0000819)2.73449645
138termination of RNA polymerase I transcription (GO:0006363)2.73182485
139protein-cofactor linkage (GO:0018065)2.73068715
140mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.72931292
141chromatin assembly or disassembly (GO:0006333)2.72303317
142cytochrome complex assembly (GO:0017004)2.69078350
143proteasome assembly (GO:0043248)2.68316226
144regulation of centrosome cycle (GO:0046605)2.67723690
145protein K6-linked ubiquitination (GO:0085020)2.67559741
146translational elongation (GO:0006414)2.67470248
147chromosome segregation (GO:0007059)2.67409389
148tRNA processing (GO:0008033)2.67002035
149synapsis (GO:0007129)2.66969634
150centriole replication (GO:0007099)2.65085526
151RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.65039509
152tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.65039509
153response to pheromone (GO:0019236)2.64847377
154rRNA modification (GO:0000154)2.64779549
155protein prenylation (GO:0018342)2.63931115
156prenylation (GO:0097354)2.63931115
157postreplication repair (GO:0006301)2.62732845
158response to X-ray (GO:0010165)2.61521246
159somatic recombination of immunoglobulin gene segments (GO:0016447)2.59751993
160nonmotile primary cilium assembly (GO:0035058)2.57872698
161rRNA catabolic process (GO:0016075)2.57654843
162tRNA metabolic process (GO:0006399)2.54864098
163somatic diversification of immunoglobulins (GO:0016445)2.54294432

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.83019804
2E2F4_17652178_ChIP-ChIP_JURKAT_Human3.97175249
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.96558160
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.93115750
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.45252289
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.19738167
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.09373060
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.03505945
9CREB1_15753290_ChIP-ChIP_HEK293T_Human2.93430261
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.87027413
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.69675395
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.69224075
13* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.65776447
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.61291693
15ZNF274_21170338_ChIP-Seq_K562_Hela2.59143438
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.51907785
17VDR_22108803_ChIP-Seq_LS180_Human2.46334426
18VDR_23849224_ChIP-Seq_CD4+_Human2.45716385
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.44779231
20FUS_26573619_Chip-Seq_HEK293_Human2.44311549
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.35771552
22EWS_26573619_Chip-Seq_HEK293_Human2.23096178
23ELK1_19687146_ChIP-ChIP_HELA_Human2.22530189
24AR_21909140_ChIP-Seq_LNCAP_Human2.18338553
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.18047844
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.16360267
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.14369010
28FOXP3_21729870_ChIP-Seq_TREG_Human2.11452608
29XRN2_22483619_ChIP-Seq_HELA_Human2.10346307
30IGF1R_20145208_ChIP-Seq_DFB_Human2.08348018
31DCP1A_22483619_ChIP-Seq_HELA_Human2.02308766
32* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.01462685
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.99983403
34E2F1_21310950_ChIP-Seq_MCF-7_Human1.98286059
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.96256711
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95128483
37* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.92441303
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.89498708
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.88032458
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.86271838
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.86255257
42NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.81802579
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.81197810
44MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.80907764
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.78829362
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.78272577
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.77132167
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.76843046
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76657614
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75335509
51* TTF2_22483619_ChIP-Seq_HELA_Human1.70374105
52RBPJ_22232070_ChIP-Seq_NCS_Mouse1.69674815
53POU5F1_16153702_ChIP-ChIP_HESCs_Human1.69389314
54GABP_19822575_ChIP-Seq_HepG2_Human1.68637652
55P300_19829295_ChIP-Seq_ESCs_Human1.68172397
56E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.67792222
57TAF15_26573619_Chip-Seq_HEK293_Human1.61808907
58POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57690949
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.57410985
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.55739005
61SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.55322146
62* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.50089604
63IRF1_19129219_ChIP-ChIP_H3396_Human1.50061430
64ERG_20887958_ChIP-Seq_HPC-7_Mouse1.46663653
65IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.46626072
66THAP11_20581084_ChIP-Seq_MESCs_Mouse1.46104643
67SRF_21415370_ChIP-Seq_HL-1_Mouse1.45839576
68KDM5A_27292631_Chip-Seq_BREAST_Human1.44723538
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.44709440
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.43063573
71ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.41169651
72GBX2_23144817_ChIP-Seq_PC3_Human1.40743950
73CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.38527972
74ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37116783
75PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36744115
76ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35492621
77SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.34579036
78FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.31939733
79TP63_19390658_ChIP-ChIP_HaCaT_Human1.30967138
80CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30838186
81CIITA_25753668_ChIP-Seq_RAJI_Human1.26799038
82GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26346950
83CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26210899
84SOX2_16153702_ChIP-ChIP_HESCs_Human1.25886466
85MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24781564
86SALL1_21062744_ChIP-ChIP_HESCs_Human1.24774536
87EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24216632
88NANOG_16153702_ChIP-ChIP_HESCs_Human1.21199486
89SPI1_23547873_ChIP-Seq_NB4_Human1.20492785
90TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16903085
91YY1_21170310_ChIP-Seq_MESCs_Mouse1.16860305
92IRF8_21731497_ChIP-ChIP_J774_Mouse1.16117435
93* CBP_20019798_ChIP-Seq_JUKART_Human1.15068251
94* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15068251
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14783982
96ER_23166858_ChIP-Seq_MCF-7_Human1.10775442
97* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09511837
98MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08644583
99* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06765790
100MYC_18940864_ChIP-ChIP_HL60_Human1.06232022
101E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04950206
102TFEB_21752829_ChIP-Seq_HELA_Human1.04233297
103IRF8_22096565_ChIP-ChIP_GC-B_Human1.04031080
104MYC_22102868_ChIP-Seq_BL_Human1.03722613
105RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03611460
106GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02319529
107ELK1_22589737_ChIP-Seq_MCF10A_Human1.01755036
108FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.01186441
109TP53_22573176_ChIP-Seq_HFKS_Human1.00644553
110GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98516029
111PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98162481
112POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98024140
113SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96752482
114EZH2_27294783_Chip-Seq_NPCs_Mouse0.95836077
115BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93699456
116STAT4_19710469_ChIP-ChIP_TH1__Mouse0.93473217
117CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92919634
118CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.92705018
119KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92689686
120SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92506029
121PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92401668
122NFE2_27457419_Chip-Seq_LIVER_Mouse0.92293619
123NANOG_19829295_ChIP-Seq_ESCs_Human0.91202828
124SOX2_19829295_ChIP-Seq_ESCs_Human0.91202828
125MYB_21317192_ChIP-Seq_ERMYB_Mouse0.89484532
126NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.89463856
127FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.88206107
128NOTCH1_21737748_ChIP-Seq_TLL_Human0.87865435
129BMI1_23680149_ChIP-Seq_NPCS_Mouse0.87690824
130TOP2B_26459242_ChIP-Seq_MCF-7_Human0.87305130
131SMAD4_21799915_ChIP-Seq_A2780_Human0.87296986
132TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.85311966
133KLF4_18555785_ChIP-Seq_MESCs_Mouse0.84859380
134OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84835001
135* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.83833346
136KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.82614244
137MYB_26560356_Chip-Seq_TH1_Human0.82003319
138MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.80870037
139CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.80593676
140STAT3_1855785_ChIP-Seq_MESCs_Mouse0.80564714
141MYB_26560356_Chip-Seq_TH2_Human0.80444587
142SOX17_20123909_ChIP-Seq_XEN_Mouse0.78261500
143SOX2_18555785_ChIP-Seq_MESCs_Mouse0.78251407
144PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.77505551
145SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.76042489
146DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.71322244

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.57331113
2MP0010094_abnormal_chromosome_stability4.07042756
3MP0008057_abnormal_DNA_replication3.90363131
4MP0004957_abnormal_blastocyst_morpholog3.78369213
5MP0006292_abnormal_olfactory_placode3.77707976
6MP0003077_abnormal_cell_cycle3.62243053
7MP0003111_abnormal_nucleus_morphology3.48970313
8MP0008058_abnormal_DNA_repair3.12633959
9MP0008007_abnormal_cellular_replicative2.86764270
10MP0002396_abnormal_hematopoietic_system2.59336411
11MP0002102_abnormal_ear_morphology2.44835158
12MP0008932_abnormal_embryonic_tissue2.41197873
13MP0003123_paternal_imprinting2.11557001
14MP0002938_white_spotting2.07933807
15MP0003787_abnormal_imprinting2.05156448
16MP0010307_abnormal_tumor_latency2.02572740
17MP0009333_abnormal_splenocyte_physiolog1.89711589
18MP0000569_abnormal_digit_pigmentation1.89470104
19MP0001730_embryonic_growth_arrest1.88829902
20MP0008877_abnormal_DNA_methylation1.84415805
21MP0000350_abnormal_cell_proliferation1.81743429
22MP0006072_abnormal_retinal_apoptosis1.76783959
23MP0001835_abnormal_antigen_presentation1.72255484
24MP0010352_gastrointestinal_tract_polyps1.72225544
25MP0001529_abnormal_vocalization1.68114606
26MP0000490_abnormal_crypts_of1.64267854
27MP0003763_abnormal_thymus_physiology1.60061457
28MP0003786_premature_aging1.56729000
29MP0004133_heterotaxia1.53967729
30MP0004808_abnormal_hematopoietic_stem1.53963959
31MP0005671_abnormal_response_to1.53745710
32MP0003567_abnormal_fetal_cardiomyocyte1.53400438
33MP0002006_tumorigenesis1.53345945
34MP0006054_spinal_hemorrhage1.52459642
35MP0001672_abnormal_embryogenesis/_devel1.46618657
36MP0005380_embryogenesis_phenotype1.46618657
37MP0009785_altered_susceptibility_to1.45364929
38MP0008789_abnormal_olfactory_epithelium1.43856277
39MP0001697_abnormal_embryo_size1.42931510
40MP0001188_hyperpigmentation1.42876887
41MP0003195_calcinosis1.42640927
42MP0001286_abnormal_eye_development1.42542974
43MP0003121_genomic_imprinting1.41194294
44MP0003718_maternal_effect1.40948650
45MP0002398_abnormal_bone_marrow1.40635500
46MP0003119_abnormal_digestive_system1.37112172
47MP0001853_heart_inflammation1.35374603
48MP0000858_altered_metastatic_potential1.35187577
49MP0000631_abnormal_neuroendocrine_gland1.34397126
50MP0003984_embryonic_growth_retardation1.34251426
51MP0000647_abnormal_sebaceous_gland1.30539557
52MP0002019_abnormal_tumor_incidence1.30202013
53MP0002088_abnormal_embryonic_growth/wei1.29899238
54MP0000372_irregular_coat_pigmentation1.29168751
55MP0009697_abnormal_copulation1.29132551
56MP0002722_abnormal_immune_system1.27831419
57MP0001800_abnormal_humoral_immune1.27746196
58MP0000689_abnormal_spleen_morphology1.27057110
59MP0000703_abnormal_thymus_morphology1.26427055
60MP0002452_abnormal_antigen_presenting1.24537922
61MP0005084_abnormal_gallbladder_morpholo1.24341101
62MP0002080_prenatal_lethality1.22642593
63MP0003950_abnormal_plasma_membrane1.22638040
64MP0002837_dystrophic_cardiac_calcinosis1.22564224
65MP0002086_abnormal_extraembryonic_tissu1.21271048
66MP0004142_abnormal_muscle_tone1.21205181
67MP0000313_abnormal_cell_death1.19167868
68MP0002420_abnormal_adaptive_immunity1.18139079
69MP0000049_abnormal_middle_ear1.17506659
70MP0001819_abnormal_immune_cell1.16670552
71MP0002233_abnormal_nose_morphology1.15309755
72MP0005551_abnormal_eye_electrophysiolog1.14951365
73MP0005000_abnormal_immune_tolerance1.14447049
74MP0001485_abnormal_pinna_reflex1.13392349
75MP0006276_abnormal_autonomic_nervous1.13004249
76MP0005253_abnormal_eye_physiology1.12783749
77MP0000427_abnormal_hair_cycle1.12758674
78MP0002751_abnormal_autonomic_nervous1.12750799
79MP0000716_abnormal_immune_system1.12665171
80MP0002723_abnormal_immune_serum1.11986506
81MP0003186_abnormal_redox_activity1.11283776
82MP0002148_abnormal_hypersensitivity_rea1.10913828
83MP0002429_abnormal_blood_cell1.10754734
84MP0004197_abnormal_fetal_growth/weight/1.10275275
85MP0004147_increased_porphyrin_level1.09583401
86MP0002210_abnormal_sex_determination1.08775433
87MP0003755_abnormal_palate_morphology1.08477133
88MP0005397_hematopoietic_system_phenotyp1.06260463
89MP0001545_abnormal_hematopoietic_system1.06260463
90MP0003646_muscle_fatigue1.05975017
91MP0002085_abnormal_embryonic_tissue1.05752528
92MP0003448_altered_tumor_morphology1.04746637
93MP0005174_abnormal_tail_pigmentation1.03855813
94MP0003315_abnormal_perineum_morphology1.03818089
95MP0002736_abnormal_nociception_after1.02994940
96MP0002234_abnormal_pharynx_morphology1.02617847
97MP0002697_abnormal_eye_size0.98965245
98MP0002132_abnormal_respiratory_system0.98425978
99MP0002084_abnormal_developmental_patter0.96015245
100MP0003941_abnormal_skin_development0.95961690
101MP0001915_intracranial_hemorrhage0.95501841
102MP0005025_abnormal_response_to0.94879957
103MP0005391_vision/eye_phenotype0.94242135
104MP0002163_abnormal_gland_morphology0.93397093
105MP0003938_abnormal_ear_development0.92353325
106MP0006035_abnormal_mitochondrial_morpho0.92103030
107MP0009379_abnormal_foot_pigmentation0.91441427
108MP0001293_anophthalmia0.90326110
109MP0005195_abnormal_posterior_eye0.89811456
110MP0002419_abnormal_innate_immunity0.89262855
111MP0004215_abnormal_myocardial_fiber0.88886329
112MP0002405_respiratory_system_inflammati0.88848969
113MP0001919_abnormal_reproductive_system0.88354965
114MP0000516_abnormal_urinary_system0.88268676
115MP0005367_renal/urinary_system_phenotyp0.88268676
116MP0000465_gastrointestinal_hemorrhage0.87866827
117MP0001119_abnormal_female_reproductive0.87611203
118MP0001145_abnormal_male_reproductive0.87527183
119MP0003283_abnormal_digestive_organ0.86676191
120MP0005499_abnormal_olfactory_system0.86561149
121MP0005394_taste/olfaction_phenotype0.86561149
122MP0002282_abnormal_trachea_morphology0.86125290
123MP0000383_abnormal_hair_follicle0.85512438
124MP0005646_abnormal_pituitary_gland0.85016144
125MP0000778_abnormal_nervous_system0.84218068
126MP0002638_abnormal_pupillary_reflex0.84142283
127MP0003943_abnormal_hepatobiliary_system0.83094574
128MP0010155_abnormal_intestine_physiology0.82620218
129MP0002166_altered_tumor_susceptibility0.82291972
130MP0003880_abnormal_central_pattern0.81662995
131MP0002277_abnormal_respiratory_mucosa0.81108859
132MP0003890_abnormal_embryonic-extraembry0.81016991
133MP0002111_abnormal_tail_morphology0.80918162
134MP0010030_abnormal_orbit_morphology0.80107688
135MP0003698_abnormal_male_reproductive0.79788244
136MP0002254_reproductive_system_inflammat0.77957516
137MP0003122_maternal_imprinting0.77373223
138MP0005387_immune_system_phenotype0.77245393
139MP0001790_abnormal_immune_system0.77245393
140MP0001929_abnormal_gametogenesis0.77047610
141MP0003806_abnormal_nucleotide_metabolis0.76916330
142MP0005076_abnormal_cell_differentiation0.76688050
143MP0000685_abnormal_immune_system0.76317649
144MP0000653_abnormal_sex_gland0.76299851
145MP0003861_abnormal_nervous_system0.76211079
146MP0003436_decreased_susceptibility_to0.75280282
147MP0005023_abnormal_wound_healing0.73708992
148MP0008995_early_reproductive_senescence0.72484298
149MP0001324_abnormal_eye_pigmentation0.72361482
150MP0002160_abnormal_reproductive_system0.71818818
151MP0002095_abnormal_skin_pigmentation0.70725193
152MP0003937_abnormal_limbs/digits/tail_de0.67362469
153MP0001243_abnormal_dermal_layer0.66675189
154MP0005389_reproductive_system_phenotype0.66447015
155MP0001845_abnormal_inflammatory_respons0.65961697
156MP0005384_cellular_phenotype0.65091312
157MP0003828_pulmonary_edema0.61873745
158MP0003221_abnormal_cardiomyocyte_apopto0.61278057
159MP0005621_abnormal_cell_physiology0.61068805
160MP0003136_yellow_coat_color0.60037381

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.70189860
2Chromsome breakage (HP:0040012)4.21460811
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.91599147
4Reticulocytopenia (HP:0001896)3.85361462
5Abnormality of chromosome stability (HP:0003220)3.44559829
6Meckel diverticulum (HP:0002245)3.27218376
7Abnormality of the preputium (HP:0100587)3.22850781
8Breast hypoplasia (HP:0003187)3.18861269
9Rough bone trabeculation (HP:0100670)3.16065961
10Pancreatic cysts (HP:0001737)3.14386603
11Abnormality of cells of the erythroid lineage (HP:0012130)3.06052015
12Pancreatic fibrosis (HP:0100732)3.04902870
13Abnormality of the ileum (HP:0001549)3.02681337
14Acute necrotizing encephalopathy (HP:0006965)3.00644066
15Abnormal number of erythroid precursors (HP:0012131)2.97294271
16Abnormality of midbrain morphology (HP:0002418)2.94014499
17Molar tooth sign on MRI (HP:0002419)2.94014499
18Cerebral hypomyelination (HP:0006808)2.81466801
19Aplasia/Hypoplasia of the uvula (HP:0010293)2.75229095
20Thrombocytosis (HP:0001894)2.73759183
21Bone marrow hypocellularity (HP:0005528)2.73099690
22Methylmalonic acidemia (HP:0002912)2.72576456
23Patellar aplasia (HP:0006443)2.72468194
24Acute encephalopathy (HP:0006846)2.72249213
25Volvulus (HP:0002580)2.69399930
26Abnormal lung lobation (HP:0002101)2.68779719
27Oral leukoplakia (HP:0002745)2.64626703
28Myelodysplasia (HP:0002863)2.63604586
29Progressive macrocephaly (HP:0004481)2.60096816
30True hermaphroditism (HP:0010459)2.56007516
31Duodenal stenosis (HP:0100867)2.54869463
32Small intestinal stenosis (HP:0012848)2.54869463
33Abnormal mitochondria in muscle tissue (HP:0008316)2.53723500
34Aplasia/Hypoplasia of the patella (HP:0006498)2.52604122
35Increased CSF lactate (HP:0002490)2.52317329
36Medial flaring of the eyebrow (HP:0010747)2.51638964
37Premature graying of hair (HP:0002216)2.50871988
38Mitochondrial inheritance (HP:0001427)2.50101338
39Pendular nystagmus (HP:0012043)2.49405337
40Degeneration of anterior horn cells (HP:0002398)2.47118618
41Abnormality of the anterior horn cell (HP:0006802)2.47118618
42Impulsivity (HP:0100710)2.46540228
43Abnormal trabecular bone morphology (HP:0100671)2.44933727
44Stenosis of the external auditory canal (HP:0000402)2.43542542
45Agnosia (HP:0010524)2.42267594
46Aplastic anemia (HP:0001915)2.41180171
47Lipid accumulation in hepatocytes (HP:0006561)2.40055997
48Lymphoma (HP:0002665)2.38955341
49Absent thumb (HP:0009777)2.38653917
50Absent radius (HP:0003974)2.37365332
51Colon cancer (HP:0003003)2.37353875
52Nephroblastoma (Wilms tumor) (HP:0002667)2.37321469
53Clubbing of toes (HP:0100760)2.36324935
54Nephronophthisis (HP:0000090)2.36211083
55Ectopic kidney (HP:0000086)2.35323517
56Duplicated collecting system (HP:0000081)2.35223524
57Macrocytic anemia (HP:0001972)2.29709855
58Embryonal renal neoplasm (HP:0011794)2.28616861
59Sloping forehead (HP:0000340)2.23755850
60Congenital primary aphakia (HP:0007707)2.22128942
61Septo-optic dysplasia (HP:0100842)2.21939263
62Abnormality of the fetal cardiovascular system (HP:0010948)2.21793273
63Abnormal umbilical cord blood vessels (HP:0011403)2.21793273
64Single umbilical artery (HP:0001195)2.21793273
65Carpal bone hypoplasia (HP:0001498)2.21325693
66Deviation of the thumb (HP:0009603)2.20166951
67Cellular immunodeficiency (HP:0005374)2.19670176
68Methylmalonic aciduria (HP:0012120)2.15866219
6911 pairs of ribs (HP:0000878)2.14870916
70Selective tooth agenesis (HP:0001592)2.13691907
71Abnormality of the renal medulla (HP:0100957)2.13279787
72Absent forearm bone (HP:0003953)2.13091966
73Aplasia involving forearm bones (HP:0009822)2.13091966
74Bilateral microphthalmos (HP:0007633)2.13064806
75Abnormality of alanine metabolism (HP:0010916)2.12415094
76Hyperalaninemia (HP:0003348)2.12415094
77Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.12415094
78Proximal placement of thumb (HP:0009623)2.11813112
79Cleft eyelid (HP:0000625)2.10779997
80Nephrogenic diabetes insipidus (HP:0009806)2.09835256
81Genital tract atresia (HP:0001827)2.09286868
82Gait imbalance (HP:0002141)2.09122147
83Abnormality of DNA repair (HP:0003254)2.07744605
84Congenital, generalized hypertrichosis (HP:0004540)2.07624323
85Homocystinuria (HP:0002156)2.06645102
86Abnormality of homocysteine metabolism (HP:0010919)2.06645102
87Cerebral edema (HP:0002181)2.06288279
88IgM deficiency (HP:0002850)2.05403348
89Vaginal atresia (HP:0000148)2.04952408
90Neoplasm of the pancreas (HP:0002894)2.04803834
91Increased serum lactate (HP:0002151)2.04438276
92Pallor (HP:0000980)2.03596619
93Abnormality of the umbilical cord (HP:0010881)2.02489578
94Sclerocornea (HP:0000647)2.02005675
95Abnormal spermatogenesis (HP:0008669)2.01598091
96Abnormality of the renal cortex (HP:0011035)2.01417049
97Abnormality of the pons (HP:0007361)2.00276494
98Abnormality of the duodenum (HP:0002246)2.00111218
99Abnormality of methionine metabolism (HP:0010901)1.98331472
100Bifid tongue (HP:0010297)1.95564460
101Abnormality of aspartate family amino acid metabolism (HP:0010899)1.95257635
102IgG deficiency (HP:0004315)1.95132138
103Atresia of the external auditory canal (HP:0000413)1.94780984
104Hepatocellular necrosis (HP:0001404)1.94533512
105Supernumerary spleens (HP:0009799)1.94147960
106Abnormality of the renal collecting system (HP:0004742)1.93385671
107Intestinal atresia (HP:0011100)1.93330025
108T lymphocytopenia (HP:0005403)1.92727965
109Horseshoe kidney (HP:0000085)1.92644082
110Hypoplasia of the capital femoral epiphysis (HP:0003090)1.92204538
111Abnormality of serum amino acid levels (HP:0003112)1.92098750
112Triphalangeal thumb (HP:0001199)1.90998404
1133-Methylglutaconic aciduria (HP:0003535)1.90827990
114Cutaneous melanoma (HP:0012056)1.90730741
115Optic nerve coloboma (HP:0000588)1.90723959
116Aplasia/Hypoplasia of the sacrum (HP:0008517)1.89406623
117Abnormality of the carotid arteries (HP:0005344)1.88320206
118Abnormality of the labia minora (HP:0012880)1.87745533
119Hypoplasia of the pons (HP:0012110)1.85846280
120Anencephaly (HP:0002323)1.85713091
121Hyperglycinemia (HP:0002154)1.85570977
122Recurrent viral infections (HP:0004429)1.85095348
123Neoplasm of the adrenal cortex (HP:0100641)1.84628511
124Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84156408
125Small hand (HP:0200055)1.84067846
126Medulloblastoma (HP:0002885)1.83057842
127Granulocytopenia (HP:0001913)1.82677538
128Chorioretinal atrophy (HP:0000533)1.82366645
129Poor coordination (HP:0002370)1.82085960
130Tracheoesophageal fistula (HP:0002575)1.81620166
131Dandy-Walker malformation (HP:0001305)1.81198098
132Abnormality of T cell number (HP:0011839)1.81142032
133Preaxial hand polydactyly (HP:0001177)1.80477521
134Pancytopenia (HP:0001876)1.80305460
135Abolished electroretinogram (ERG) (HP:0000550)1.79957758
136Abnormality of B cell number (HP:0010975)1.79645712
137B lymphocytopenia (HP:0010976)1.79645712
138Squamous cell carcinoma (HP:0002860)1.79391670
139Gastrointestinal atresia (HP:0002589)1.79004283
140Blepharitis (HP:0000498)1.78437616
141Rhabdomyosarcoma (HP:0002859)1.78236020
142Optic nerve hypoplasia (HP:0000609)1.77695684
143Eosinophilia (HP:0001880)1.77606335
144Abnormal number of incisors (HP:0011064)1.77133779
145Congenital stationary night blindness (HP:0007642)1.76955957
146Acute myeloid leukemia (HP:0004808)1.76923750
147Poikiloderma (HP:0001029)1.76254237
148Glossoptosis (HP:0000162)1.76055650
149Aplasia/Hypoplasia of the tibia (HP:0005772)1.75586478
150Median cleft lip (HP:0000161)1.74893166
151Entropion (HP:0000621)1.74556686
152Abnormality of the vitamin B12 metabolism (HP:0004341)1.74465641
153Poor head control (HP:0002421)1.73261792
154Type I transferrin isoform profile (HP:0003642)1.72719331
155Optic disc pallor (HP:0000543)1.72707307
156Pulmonary fibrosis (HP:0002206)1.70986279
157Aseptic necrosis (HP:0010885)1.70074553
158Hypothermia (HP:0002045)1.70065048
159Recurrent bronchitis (HP:0002837)1.69949508
160Renal cortical cysts (HP:0000803)1.69738556
161Breast carcinoma (HP:0003002)1.69022523
162Abnormality of vitamin B metabolism (HP:0004340)1.68824707
163Ureteral duplication (HP:0000073)1.68594078
164Secondary amenorrhea (HP:0000869)1.68517733
165Facial cleft (HP:0002006)1.68294322
166Leukopenia (HP:0001882)1.68205591
167Adrenal hypoplasia (HP:0000835)1.68195437
168Short thumb (HP:0009778)1.68109550
169Glioma (HP:0009733)1.68015905
170Anophthalmia (HP:0000528)1.67790300
171Increased hepatocellular lipid droplets (HP:0006565)1.67526227
172Postaxial foot polydactyly (HP:0001830)1.66683433
173Oligodactyly (hands) (HP:0001180)1.66398028

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.66454921
2WEE13.58399826
3CDC73.49041319
4EIF2AK13.38236185
5FRK2.92661426
6SRPK12.76307136
7MAP4K22.51392867
8BRSK22.49842364
9PBK2.49760607
10BMPR1B2.44994575
11WNK32.40736401
12NEK22.33021098
13MKNK12.29530061
14TSSK62.28304982
15PLK42.18034666
16NME22.17069598
17TNIK2.08483076
18EIF2AK31.93225609
19ZAK1.88480010
20PNCK1.87275636
21MKNK21.85174065
22TTK1.81809772
23MST41.78189120
24PLK11.71656763
25ACVR1B1.71029566
26RPS6KA41.63857471
27VRK11.62657848
28PASK1.60539379
29STK161.57975693
30PLK31.54975303
31TXK1.54942554
32TAF11.53568579
33ATR1.52817603
34TRIM281.51812975
35* AURKB1.51521846
36VRK21.47705217
37NEK11.45776547
38TLK11.44684746
39CASK1.44466872
40MAP3K141.36932357
41IRAK31.35432929
42STK391.34694774
43CDK71.31922145
44ADRBK21.30290820
45GRK11.27465797
46STK101.27047230
47OXSR11.26465593
48PLK21.26362570
49MAP4K11.23236671
50EIF2AK21.17980892
51JAK31.17095838
52STK38L1.15309684
53NUAK11.15045779
54MAP3K41.14580403
55CHEK21.12698421
56STK41.10592665
57WNK41.09824794
58BRSK11.07309988
59IRAK41.06656645
60CSNK1G11.05226480
61NEK91.04878654
62RPS6KB21.04690859
63DYRK21.03726428
64PIM11.03037809
65CDK81.02382615
66DYRK31.01084804
67AKT31.00290513
68MAP2K70.97695951
69CHUK0.96564485
70MAP3K80.95741841
71CHEK10.95603666
72TESK20.95546105
73TEC0.94501135
74CDK120.90650964
75ATM0.88899356
76CDK40.85193925
77TGFBR10.84649058
78CLK10.82074197
79AURKA0.81749103
80PDK20.81742568
81MELK0.80610915
82FLT30.78967015
83STK30.78190438
84RPS6KA50.78138213
85CDK60.76477965
86IKBKB0.76137021
87TIE10.75211623
88PAK40.75074327
89INSRR0.74735972
90CDK30.74582205
91CSNK1G20.70411438
92CSNK2A20.69423749
93MAPK130.69135001
94CSNK2A10.68702083
95IKBKE0.66970857
96PIK3CA0.66382660
97CDK20.65874423
98TBK10.65376467
99CCNB10.65166073
100TAOK30.64401125
101CSNK1G30.63400276
102CAMK1G0.63353835
103PINK10.61434163
104BTK0.59540473
105FGFR20.59075152
106SCYL20.57500135
107ZAP700.56482274
108PRKCG0.56005872
109YES10.54850915
110PIM20.54361137
111CSNK1A1L0.53196634
112CAMK1D0.53045378
113CSNK1E0.53034622
114FGFR10.52275207
115CDK10.52062325
116MARK30.49123232
117TYK20.49022382
118EPHA20.46873796
119NLK0.46524935
120PRKCE0.46376510
121IRAK10.45775553
122KIT0.45225262
123ALK0.45055499
124LCK0.43719996
125ERBB40.43229858
126CAMKK20.40904138
127PAK30.40527252
128PIK3CG0.38711419
129CSNK1A10.38291127
130BRD40.35628155
131ITK0.35588974
132BCR0.35308732
133NME10.34625283
134PAK10.32973522
135FER0.32563938
136BRAF0.31591537
137TESK10.31331335
138PAK20.31292616
139CSF1R0.31056692
140BCKDK0.29058192
141LYN0.28642675
142PRKACB0.28475007
143ERBB30.28294930
144CDK90.27397062
145PRKDC0.27340032
146PRKCI0.23873557

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.12514734
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.62211047
3Mismatch repair_Homo sapiens_hsa034303.55595696
4Proteasome_Homo sapiens_hsa030503.24698835
5RNA polymerase_Homo sapiens_hsa030203.13297014
6Ribosome_Homo sapiens_hsa030102.98319288
7Spliceosome_Homo sapiens_hsa030402.88045326
8Nucleotide excision repair_Homo sapiens_hsa034202.77619097
9RNA transport_Homo sapiens_hsa030132.76399349
10Homologous recombination_Homo sapiens_hsa034402.71183755
11Oxidative phosphorylation_Homo sapiens_hsa001902.53321328
12Cell cycle_Homo sapiens_hsa041102.50387777
13Base excision repair_Homo sapiens_hsa034102.47854909
14Non-homologous end-joining_Homo sapiens_hsa034502.34706865
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.23287347
16Fanconi anemia pathway_Homo sapiens_hsa034602.17893020
17Pyrimidine metabolism_Homo sapiens_hsa002402.15615409
18One carbon pool by folate_Homo sapiens_hsa006702.15424768
19Parkinsons disease_Homo sapiens_hsa050122.14484622
20Basal transcription factors_Homo sapiens_hsa030222.13402584
21RNA degradation_Homo sapiens_hsa030182.04973474
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.89069868
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.88094322
24Propanoate metabolism_Homo sapiens_hsa006401.83359376
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.79676216
26mRNA surveillance pathway_Homo sapiens_hsa030151.55031673
27p53 signaling pathway_Homo sapiens_hsa041151.48788685
28Graft-versus-host disease_Homo sapiens_hsa053321.47172124
29Antigen processing and presentation_Homo sapiens_hsa046121.40360246
30Protein export_Homo sapiens_hsa030601.33641277
31Epstein-Barr virus infection_Homo sapiens_hsa051691.33286014
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33115622
33Herpes simplex infection_Homo sapiens_hsa051681.32498409
34Alzheimers disease_Homo sapiens_hsa050101.28586171
35Butanoate metabolism_Homo sapiens_hsa006501.24474215
36Purine metabolism_Homo sapiens_hsa002301.20980498
37NF-kappa B signaling pathway_Homo sapiens_hsa040641.17589040
38Systemic lupus erythematosus_Homo sapiens_hsa053221.16237074
39Legionellosis_Homo sapiens_hsa051341.15082430
40Measles_Homo sapiens_hsa051621.12644494
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.09192572
42NOD-like receptor signaling pathway_Homo sapiens_hsa046211.08032087
43Primary immunodeficiency_Homo sapiens_hsa053401.08025040
44Phototransduction_Homo sapiens_hsa047441.05275104
45Pyruvate metabolism_Homo sapiens_hsa006201.00671768
46Nitrogen metabolism_Homo sapiens_hsa009101.00126888
47Viral carcinogenesis_Homo sapiens_hsa052030.99729133
48Vitamin B6 metabolism_Homo sapiens_hsa007500.98969530
49Tryptophan metabolism_Homo sapiens_hsa003800.98459873
50Intestinal immune network for IgA production_Homo sapiens_hsa046720.96014689
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.95826270
52Caffeine metabolism_Homo sapiens_hsa002320.93824464
53Leishmaniasis_Homo sapiens_hsa051400.91416186
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90142358
55Allograft rejection_Homo sapiens_hsa053300.88086247
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87898955
57Cardiac muscle contraction_Homo sapiens_hsa042600.87319770
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82461247
59Hematopoietic cell lineage_Homo sapiens_hsa046400.81615754
60Fatty acid elongation_Homo sapiens_hsa000620.81072248
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80274736
62Linoleic acid metabolism_Homo sapiens_hsa005910.79247048
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77601115
64Type I diabetes mellitus_Homo sapiens_hsa049400.77513100
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.75453535
66Hedgehog signaling pathway_Homo sapiens_hsa043400.74264901
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72779964
68HTLV-I infection_Homo sapiens_hsa051660.72766254
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71619402
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71425095
71Sulfur metabolism_Homo sapiens_hsa009200.70916302
72Peroxisome_Homo sapiens_hsa041460.70241748
73Metabolic pathways_Homo sapiens_hsa011000.69495312
74Oocyte meiosis_Homo sapiens_hsa041140.68829209
75Folate biosynthesis_Homo sapiens_hsa007900.68393412
76Basal cell carcinoma_Homo sapiens_hsa052170.67141405
77Nicotine addiction_Homo sapiens_hsa050330.67140734
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67078608
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.66747882
80Influenza A_Homo sapiens_hsa051640.63301147
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60556414
82Chemical carcinogenesis_Homo sapiens_hsa052040.59608026
83Ether lipid metabolism_Homo sapiens_hsa005650.58819021
84Small cell lung cancer_Homo sapiens_hsa052220.58373534
85Apoptosis_Homo sapiens_hsa042100.57158855
86MicroRNAs in cancer_Homo sapiens_hsa052060.57030237
87Shigellosis_Homo sapiens_hsa051310.56129045
88Thyroid cancer_Homo sapiens_hsa052160.55728308
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55727766
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55653039
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55482276
92Autoimmune thyroid disease_Homo sapiens_hsa053200.55095334
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54993082
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.53226372
95Retinol metabolism_Homo sapiens_hsa008300.52413737
96Sulfur relay system_Homo sapiens_hsa041220.52182176
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52121657
98Pentose phosphate pathway_Homo sapiens_hsa000300.51784970
99Hepatitis B_Homo sapiens_hsa051610.51727456
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.51240400
101beta-Alanine metabolism_Homo sapiens_hsa004100.51137272
102Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49927583
103Taste transduction_Homo sapiens_hsa047420.49335940
104TGF-beta signaling pathway_Homo sapiens_hsa043500.49077129
105Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48510085
106Malaria_Homo sapiens_hsa051440.47660876
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47104016
108Selenocompound metabolism_Homo sapiens_hsa004500.44987273
109Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44024983
110Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43853084
111Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43591949
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43369440
113Primary bile acid biosynthesis_Homo sapiens_hsa001200.43148868
114Steroid biosynthesis_Homo sapiens_hsa001000.42380462
115Vitamin digestion and absorption_Homo sapiens_hsa049770.41712149
116Fat digestion and absorption_Homo sapiens_hsa049750.41704559
117Regulation of autophagy_Homo sapiens_hsa041400.41387081
118Asthma_Homo sapiens_hsa053100.40643995
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40609003
120Jak-STAT signaling pathway_Homo sapiens_hsa046300.40488961
121Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40389828
122Viral myocarditis_Homo sapiens_hsa054160.39976873
123T cell receptor signaling pathway_Homo sapiens_hsa046600.39343724
124Toll-like receptor signaling pathway_Homo sapiens_hsa046200.39120814
125Wnt signaling pathway_Homo sapiens_hsa043100.37503262
126Huntingtons disease_Homo sapiens_hsa050160.36596373
127Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.35317303
128Olfactory transduction_Homo sapiens_hsa047400.35265998
129Cysteine and methionine metabolism_Homo sapiens_hsa002700.34836961
130Glutathione metabolism_Homo sapiens_hsa004800.30809479
131Prostate cancer_Homo sapiens_hsa052150.29970849
132Pertussis_Homo sapiens_hsa051330.29864755
133Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29835222
134Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.29537441
135Glycerolipid metabolism_Homo sapiens_hsa005610.28193388
136TNF signaling pathway_Homo sapiens_hsa046680.27978144
137Fatty acid degradation_Homo sapiens_hsa000710.27031965
138Leukocyte transendothelial migration_Homo sapiens_hsa046700.26687066
139Toxoplasmosis_Homo sapiens_hsa051450.25740057
140HIF-1 signaling pathway_Homo sapiens_hsa040660.25298437
141Osteoclast differentiation_Homo sapiens_hsa043800.24976791
142Fatty acid metabolism_Homo sapiens_hsa012120.24650788
143Rheumatoid arthritis_Homo sapiens_hsa053230.23944951
144Adherens junction_Homo sapiens_hsa045200.21902866
145Salmonella infection_Homo sapiens_hsa051320.21312281
146B cell receptor signaling pathway_Homo sapiens_hsa046620.20911544
147Hippo signaling pathway_Homo sapiens_hsa043900.20732189
148Lysine degradation_Homo sapiens_hsa003100.20705993
149Biosynthesis of amino acids_Homo sapiens_hsa012300.20339023
150Cyanoamino acid metabolism_Homo sapiens_hsa004600.19202285
151Hepatitis C_Homo sapiens_hsa051600.19061371
152Alcoholism_Homo sapiens_hsa050340.18816687
153Arginine and proline metabolism_Homo sapiens_hsa003300.18798956
154Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.17690956
155Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.17561714

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