DDX55

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of protein family containing a characteristic Asp-Glu-Ala-Asp (DEAD) motif. These proteins are putative RNA helicases, and may be involved in a range of nuclear processes including translational initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Multiple alternatively spliced transcript variants have been found for this gene. Pseudogenes have been identified on chromosomes 1 and 12. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)4.53033492
2transcription from mitochondrial promoter (GO:0006390)4.32284635
3DNA strand elongation involved in DNA replication (GO:0006271)4.31539749
4DNA strand elongation (GO:0022616)4.13680265
5DNA replication checkpoint (GO:0000076)4.13147408
6telomere maintenance via semi-conservative replication (GO:0032201)4.11997868
7presynaptic membrane organization (GO:0097090)4.08242290
8maturation of SSU-rRNA (GO:0030490)4.01658518
9regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.00807970
10regulation of mitotic spindle checkpoint (GO:1903504)4.00807970
11telomere maintenance via recombination (GO:0000722)3.99789564
12replication fork processing (GO:0031297)3.91695389
13mitochondrial RNA metabolic process (GO:0000959)3.89185228
14regulation of mitochondrial translation (GO:0070129)3.78616938
15mitotic recombination (GO:0006312)3.78229085
16viral mRNA export from host cell nucleus (GO:0046784)3.77614240
17nucleobase biosynthetic process (GO:0046112)3.66531912
18somatic hypermutation of immunoglobulin genes (GO:0016446)3.55564906
19somatic diversification of immune receptors via somatic mutation (GO:0002566)3.55564906
20ribosome biogenesis (GO:0042254)3.53656011
21DNA double-strand break processing (GO:0000729)3.51855555
22mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.46295674
23meiotic chromosome segregation (GO:0045132)3.45615102
24DNA replication initiation (GO:0006270)3.43869142
25maturation of 5.8S rRNA (GO:0000460)3.42190412
26transcription elongation from RNA polymerase I promoter (GO:0006362)3.41321414
27ribonucleoprotein complex biogenesis (GO:0022613)3.36404040
28purine nucleobase biosynthetic process (GO:0009113)3.34085515
29postsynaptic membrane organization (GO:0001941)3.33684829
30DNA unwinding involved in DNA replication (GO:0006268)3.32824600
31kinetochore organization (GO:0051383)3.30702893
32maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.29561413
33recombinational repair (GO:0000725)3.29463016
34ribosomal large subunit biogenesis (GO:0042273)3.29066663
35double-strand break repair via homologous recombination (GO:0000724)3.28760455
36termination of RNA polymerase I transcription (GO:0006363)3.28087677
37nuclear pore complex assembly (GO:0051292)3.27523363
38nucleotide-excision repair, DNA gap filling (GO:0006297)3.27250506
39regulation of nuclear cell cycle DNA replication (GO:0033262)3.24085671
40mitochondrial respiratory chain complex assembly (GO:0033108)3.23832990
41telomere maintenance via telomere lengthening (GO:0010833)3.20027200
42axonemal dynein complex assembly (GO:0070286)3.19188823
43ribosome assembly (GO:0042255)3.18656946
44keratinocyte development (GO:0003334)3.17059867
45regulation of centriole replication (GO:0046599)3.14544716
46cellular component biogenesis (GO:0044085)3.14080792
47positive regulation of protein sumoylation (GO:0033235)3.14043157
48nuclear pore organization (GO:0006999)3.11050448
49ribosomal small subunit assembly (GO:0000028)3.08819997
50termination of RNA polymerase III transcription (GO:0006386)3.08006679
51transcription elongation from RNA polymerase III promoter (GO:0006385)3.08006679
52folic acid-containing compound biosynthetic process (GO:0009396)3.07691322
53GPI anchor biosynthetic process (GO:0006506)3.05956654
54double-strand break repair via nonhomologous end joining (GO:0006303)3.05219937
55non-recombinational repair (GO:0000726)3.05219937
56ncRNA processing (GO:0034470)3.04516010
57ATP synthesis coupled proton transport (GO:0015986)3.03733232
58energy coupled proton transport, down electrochemical gradient (GO:0015985)3.03733232
59pore complex assembly (GO:0046931)3.03484881
60cytochrome complex assembly (GO:0017004)3.01840617
61negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.97269935
62preassembly of GPI anchor in ER membrane (GO:0016254)2.95810383
63spliceosomal snRNP assembly (GO:0000387)2.95612922
64intraciliary transport (GO:0042073)2.95511770
65neuron cell-cell adhesion (GO:0007158)2.93918699
66somatic diversification of immunoglobulins (GO:0016445)2.93748344
67regulation of double-strand break repair via homologous recombination (GO:0010569)2.93606965
68positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.93223271
69histone exchange (GO:0043486)2.93203844
70ncRNA metabolic process (GO:0034660)2.92372879
71histone H2B ubiquitination (GO:0033523)2.92371084
72negative regulation of DNA-dependent DNA replication (GO:2000104)2.91957423
73tRNA metabolic process (GO:0006399)2.91728069
74somatic recombination of immunoglobulin gene segments (GO:0016447)2.90299873
75microtubule depolymerization (GO:0007019)2.89584082
76histone H3-K4 trimethylation (GO:0080182)2.89567817
77mitotic nuclear envelope disassembly (GO:0007077)2.89009769
78IMP biosynthetic process (GO:0006188)2.88342339
79mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.87859503
80mitochondrial respiratory chain complex I assembly (GO:0032981)2.87859503
81NADH dehydrogenase complex assembly (GO:0010257)2.87859503
82negative regulation of mRNA processing (GO:0050686)2.86568918
83mitotic sister chromatid segregation (GO:0000070)2.86536579
84isotype switching (GO:0045190)2.84765176
85somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.84765176
86somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.84765176
87RNA capping (GO:0036260)2.84764410
887-methylguanosine RNA capping (GO:0009452)2.84764410
897-methylguanosine mRNA capping (GO:0006370)2.84433140
90negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.84103349
91inner mitochondrial membrane organization (GO:0007007)2.83777268
92telomere maintenance (GO:0000723)2.83628435
93DNA damage response, detection of DNA damage (GO:0042769)2.83407271
94formation of translation preinitiation complex (GO:0001731)2.83076389
95negative regulation of RNA splicing (GO:0033119)2.82740057
96telomere organization (GO:0032200)2.81973705
97mannosylation (GO:0097502)2.81650547
98axoneme assembly (GO:0035082)2.80086847
99transcription from RNA polymerase I promoter (GO:0006360)2.77776552
100GPI anchor metabolic process (GO:0006505)2.75782878
101protein prenylation (GO:0018342)2.73780941
102prenylation (GO:0097354)2.73780941
103regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.72360344
104tRNA methylation (GO:0030488)2.70877273
105left/right axis specification (GO:0070986)2.68603799
106transcription initiation from RNA polymerase I promoter (GO:0006361)2.67692951
107long-chain fatty acid biosynthetic process (GO:0042759)2.66732852
108metallo-sulfur cluster assembly (GO:0031163)2.66256464
109iron-sulfur cluster assembly (GO:0016226)2.66256464
110proteasome assembly (GO:0043248)2.61785148
111centriole assembly (GO:0098534)2.61421345
112GTP biosynthetic process (GO:0006183)2.59302821
113startle response (GO:0001964)2.58950035
114DNA strand renaturation (GO:0000733)2.58391457
115cilium assembly (GO:0042384)2.58212030
116nonmotile primary cilium assembly (GO:0035058)2.57464679
117respiratory chain complex IV assembly (GO:0008535)2.57149664
118DNA ligation (GO:0006266)2.56624076
119mRNA splice site selection (GO:0006376)2.55568602
120positive regulation of histone H3-K4 methylation (GO:0051571)2.53864757
121nucleotide transmembrane transport (GO:1901679)2.53798211
122tRNA modification (GO:0006400)2.50992841
123cilium organization (GO:0044782)2.48629033
124developmental pigmentation (GO:0048066)2.47250930
125RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.46664311
126tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.46664311
127DNA catabolic process, exonucleolytic (GO:0000738)2.46620072
128CENP-A containing nucleosome assembly (GO:0034080)2.46134194
129pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.45493057
130protein localization to cilium (GO:0061512)2.43768038
131mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.43314360
132regulation of timing of cell differentiation (GO:0048505)2.42486492
133tRNA processing (GO:0008033)2.42347750
134exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.42305423
135ribosomal small subunit biogenesis (GO:0042274)2.41968470
136centriole replication (GO:0007099)2.40463135
137nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.40351562
138chromatin remodeling at centromere (GO:0031055)2.39365208
139establishment of protein localization to mitochondrial membrane (GO:0090151)2.37995321
140rRNA modification (GO:0000154)2.37813170
141axon ensheathment in central nervous system (GO:0032291)2.37009996
142central nervous system myelination (GO:0022010)2.37009996
143protein complex biogenesis (GO:0070271)2.36914269
144cilium movement (GO:0003341)2.36014994
145rRNA methylation (GO:0031167)2.35171761
146deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.35086752
147transcription-coupled nucleotide-excision repair (GO:0006283)2.34826649
148guanosine-containing compound biosynthetic process (GO:1901070)2.33726110
149pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.32687912
150peptidyl-histidine modification (GO:0018202)2.30252960
151regulation of development, heterochronic (GO:0040034)2.29163048
152DNA-templated transcription, elongation (GO:0006354)2.27517889
153positive regulation of DNA-templated transcription, elongation (GO:0032786)2.27149048
154DNA topological change (GO:0006265)2.26525116
155establishment of integrated proviral latency (GO:0075713)2.25382243
156regulation of mRNA splicing, via spliceosome (GO:0048024)2.24324557
157deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.22232099
158C-terminal protein lipidation (GO:0006501)2.21944237
159poly(A)+ mRNA export from nucleus (GO:0016973)2.21888193
160rRNA processing (GO:0006364)2.20919445
161rRNA metabolic process (GO:0016072)2.20849105
162transmission of nerve impulse (GO:0019226)2.20232568
163pseudouridine synthesis (GO:0001522)2.19677524
164kinetochore assembly (GO:0051382)2.19632169
165motile cilium assembly (GO:0044458)2.19535498
166RNA methylation (GO:0001510)2.19365077
167limb bud formation (GO:0060174)2.19334706
168transcription elongation from RNA polymerase II promoter (GO:0006368)2.18544259
169spliceosomal complex assembly (GO:0000245)2.18268477
170positive regulation of protein homodimerization activity (GO:0090073)2.17806142
171transcription from RNA polymerase III promoter (GO:0006383)2.17396086
172DNA deamination (GO:0045006)2.17296310

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.17734050
2EZH2_22144423_ChIP-Seq_EOC_Human3.01726526
3CREB1_15753290_ChIP-ChIP_HEK293T_Human2.98658184
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.93893998
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.92052818
6GBX2_23144817_ChIP-Seq_PC3_Human2.92004303
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.80863826
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.75305962
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.54147527
10E2F7_22180533_ChIP-Seq_HELA_Human2.52332887
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.35264328
12* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.35056200
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.32341940
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.31670410
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.30087287
16XRN2_22483619_ChIP-Seq_HELA_Human2.29454934
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.24545409
18BMI1_23680149_ChIP-Seq_NPCS_Mouse2.23321753
19E2F1_21310950_ChIP-Seq_MCF-7_Human2.21289376
20PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.20040919
21* GABP_19822575_ChIP-Seq_HepG2_Human2.19495625
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.17692198
23IRF1_19129219_ChIP-ChIP_H3396_Human2.17285140
24DCP1A_22483619_ChIP-Seq_HELA_Human2.13253336
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.07514808
26TAF15_26573619_Chip-Seq_HEK293_Human2.02227860
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.00635619
28KDM5A_27292631_Chip-Seq_BREAST_Human1.98816636
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.92926109
30PADI4_21655091_ChIP-ChIP_MCF-7_Human1.92609921
31* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.86388185
32KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.85549164
33VDR_22108803_ChIP-Seq_LS180_Human1.83396683
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.78208920
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.77180288
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.76730688
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.75437065
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.74910164
39FUS_26573619_Chip-Seq_HEK293_Human1.74168940
40MYCN_18555785_ChIP-Seq_MESCs_Mouse1.72256674
41MYC_18940864_ChIP-ChIP_HL60_Human1.70758915
42ETS1_20019798_ChIP-Seq_JURKAT_Human1.70581201
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.69952702
44CIITA_25753668_ChIP-Seq_RAJI_Human1.65215438
45POU5F1_16153702_ChIP-ChIP_HESCs_Human1.64286833
46RNF2_27304074_Chip-Seq_NSC_Mouse1.62329752
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.61552351
48CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.59900406
49CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.55291753
50* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.54628472
51SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.53947344
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50977589
53E2F4_17652178_ChIP-ChIP_JURKAT_Human1.50145584
54* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.49179589
55CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48386842
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47123038
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.47115011
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46941672
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46691488
60MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.46068392
61* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.45849681
62EWS_26573619_Chip-Seq_HEK293_Human1.43470522
63* VDR_23849224_ChIP-Seq_CD4+_Human1.42880194
64CBX2_27304074_Chip-Seq_ESCs_Mouse1.41342316
65NFE2_27457419_Chip-Seq_LIVER_Mouse1.41166031
66ZNF274_21170338_ChIP-Seq_K562_Hela1.38939315
67* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38618040
68BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.37547564
69GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.37223284
70THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37182877
71TP63_19390658_ChIP-ChIP_HaCaT_Human1.33703106
72NANOG_18555785_Chip-Seq_ESCs_Mouse1.33341692
73SUZ12_18555785_Chip-Seq_ESCs_Mouse1.31991384
74P300_19829295_ChIP-Seq_ESCs_Human1.31662322
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30998263
76* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.30962207
77REST_21632747_ChIP-Seq_MESCs_Mouse1.30424252
78E2F1_18555785_Chip-Seq_ESCs_Mouse1.30246478
79JARID2_20064375_ChIP-Seq_MESCs_Mouse1.30059237
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.29339965
81EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.29095890
82ELK1_19687146_ChIP-ChIP_HELA_Human1.28185514
83STAT3_18555785_Chip-Seq_ESCs_Mouse1.27854062
84EZH2_27304074_Chip-Seq_ESCs_Mouse1.27658061
85ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26433546
86SALL1_21062744_ChIP-ChIP_HESCs_Human1.25331718
87ER_23166858_ChIP-Seq_MCF-7_Human1.25191513
88NMYC_18555785_Chip-Seq_ESCs_Mouse1.25050909
89FOXP3_21729870_ChIP-Seq_TREG_Human1.24782044
90CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.24521055
91P53_22387025_ChIP-Seq_ESCs_Mouse1.24264083
92ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23748542
93EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.23633435
94PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.21919993
95RUNX1_27457419_Chip-Seq_LIVER_Mouse1.20770611
96SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19859974
97CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19304369
98AR_21909140_ChIP-Seq_LNCAP_Human1.18461357
99P300_18555785_Chip-Seq_ESCs_Mouse1.18389593
100CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.18020914
101SRF_21415370_ChIP-Seq_HL-1_Mouse1.16119080
102IGF1R_20145208_ChIP-Seq_DFB_Human1.15215085
103EZH2_27294783_Chip-Seq_NPCs_Mouse1.14556182
104CMYC_18555785_Chip-Seq_ESCs_Mouse1.13102361
105SOX2_18555785_Chip-Seq_ESCs_Mouse1.12894120
106ZFX_18555785_Chip-Seq_ESCs_Mouse1.11350304
107* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11045859
108* MYC_18555785_ChIP-Seq_MESCs_Mouse1.09381006
109MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.09227760
110KLF4_18555785_Chip-Seq_ESCs_Mouse1.08877768
111ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.08646928
112* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08255348
113TTF2_22483619_ChIP-Seq_HELA_Human1.07482243
114SMAD1_18555785_Chip-Seq_ESCs_Mouse1.05435720
115TAL1_26923725_Chip-Seq_HPCs_Mouse1.05316316
116CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04636390
117OCT4_18555785_Chip-Seq_ESCs_Mouse1.03531774
118EED_16625203_ChIP-ChIP_MESCs_Mouse1.02624541
119* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.02544566
120* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01510372
121SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.01419424
122* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00796840
123CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.00748335
124ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00608074
125PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00178746
126* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99998502
127SMAD3_21741376_ChIP-Seq_EPCs_Human0.98291753
128MYC_19079543_ChIP-ChIP_MESCs_Mouse0.97932723
129* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97905964
130POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97758714
131TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97758714
132NANOG_18555785_ChIP-Seq_MESCs_Mouse0.97002851
133* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.96000451
134PU1_27457419_Chip-Seq_LIVER_Mouse0.93760907
135ESRRB_18555785_Chip-Seq_ESCs_Mouse0.93383785
136SOX9_26525672_Chip-Seq_HEART_Mouse0.92942474
137* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.92189282
138DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.92145447
139SMAD4_21799915_ChIP-Seq_A2780_Human0.92140806
140CTCF_18555785_Chip-Seq_ESCs_Mouse0.91465673
141POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.90480130
142MYC_22102868_ChIP-Seq_BL_Human0.86225784
143TFEB_21752829_ChIP-Seq_HELA_Human0.85349503
144* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85120839
145CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84884620
146* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.78489584
147EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.74732425
148ELK1_22589737_ChIP-Seq_MCF10A_Human0.74359323
149TP53_22573176_ChIP-Seq_HFKS_Human0.73933454
150* FOXP1_21924763_ChIP-Seq_HESCs_Human0.73727021
151* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.73154953
152ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.67953591
153KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.67608615
154CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.66847800
155HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.66764659
156STAT3_1855785_ChIP-Seq_MESCs_Mouse0.66123414
157RBPJ_22232070_ChIP-Seq_NCS_Mouse0.65038243
158SOX2_16153702_ChIP-ChIP_HESCs_Human0.64485340
159SOX2_18555785_ChIP-Seq_MESCs_Mouse0.64404549
160CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.63674308

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.61689067
2MP0001188_hyperpigmentation3.53476166
3MP0003880_abnormal_central_pattern3.19648558
4MP0003136_yellow_coat_color3.16713720
5MP0003787_abnormal_imprinting2.50136212
6MP0005645_abnormal_hypothalamus_physiol2.31713685
7MP0001986_abnormal_taste_sensitivity2.28043620
8MP0008007_abnormal_cellular_replicative2.27294707
9MP0008058_abnormal_DNA_repair2.24711879
10MP0009697_abnormal_copulation2.19831775
11MP0008057_abnormal_DNA_replication2.17738930
12MP0003806_abnormal_nucleotide_metabolis2.12726186
13MP0005423_abnormal_somatic_nervous2.10108319
14MP0001984_abnormal_olfaction2.09601155
15MP0005409_darkened_coat_color2.07805373
16MP0004381_abnormal_hair_follicle2.01511559
17MP0002638_abnormal_pupillary_reflex1.90868745
18MP0005646_abnormal_pituitary_gland1.86686748
19MP0002396_abnormal_hematopoietic_system1.82195022
20MP0001529_abnormal_vocalization1.78223435
21MP0008877_abnormal_DNA_methylation1.77279262
22MP0000015_abnormal_ear_pigmentation1.75623221
23MP0004147_increased_porphyrin_level1.73257764
24MP0006035_abnormal_mitochondrial_morpho1.66902091
25MP0006072_abnormal_retinal_apoptosis1.66334172
26MP0009745_abnormal_behavioral_response1.62408696
27MP0001905_abnormal_dopamine_level1.61918866
28MP0002272_abnormal_nervous_system1.61480317
29MP0003693_abnormal_embryo_hatching1.60221904
30MP0000566_synostosis1.59953368
31MP0001486_abnormal_startle_reflex1.58594131
32MP0009046_muscle_twitch1.57737968
33MP0008875_abnormal_xenobiotic_pharmacok1.55810164
34MP0010094_abnormal_chromosome_stability1.54033450
35MP0000350_abnormal_cell_proliferation1.53921532
36MP0005551_abnormal_eye_electrophysiolog1.53090471
37MP0006036_abnormal_mitochondrial_physio1.52165808
38MP0003111_abnormal_nucleus_morphology1.52088822
39MP0010386_abnormal_urinary_bladder1.48664296
40MP0009379_abnormal_foot_pigmentation1.48437124
41MP0006276_abnormal_autonomic_nervous1.46946682
42MP0001968_abnormal_touch/_nociception1.45372286
43MP0005394_taste/olfaction_phenotype1.42423980
44MP0005499_abnormal_olfactory_system1.42423980
45MP0004142_abnormal_muscle_tone1.41199564
46MP0002572_abnormal_emotion/affect_behav1.40846937
47MP0003718_maternal_effect1.40654729
48MP0003635_abnormal_synaptic_transmissio1.39766803
49MP0002734_abnormal_mechanical_nocicepti1.39761095
50MP0005379_endocrine/exocrine_gland_phen1.39537864
51MP0008789_abnormal_olfactory_epithelium1.39158964
52MP0004742_abnormal_vestibular_system1.38604371
53MP0002064_seizures1.38008182
54MP0003121_genomic_imprinting1.37036416
55MP0008872_abnormal_physiological_respon1.35525605
56MP0005171_absent_coat_pigmentation1.34703035
57MP0000372_irregular_coat_pigmentation1.33319723
58MP0000313_abnormal_cell_death1.32204542
59MP0001501_abnormal_sleep_pattern1.31463512
60MP0002735_abnormal_chemical_nociception1.30106914
61MP0002102_abnormal_ear_morphology1.29006402
62MP0003186_abnormal_redox_activity1.28774850
63MP0005174_abnormal_tail_pigmentation1.28340494
64MP0008995_early_reproductive_senescence1.28146588
65MP0004133_heterotaxia1.27224248
66MP0003122_maternal_imprinting1.26852446
67MP0001929_abnormal_gametogenesis1.26692669
68MP0000631_abnormal_neuroendocrine_gland1.26619304
69MP0001730_embryonic_growth_arrest1.26392331
70MP0001697_abnormal_embryo_size1.26338105
71MP0002277_abnormal_respiratory_mucosa1.25785347
72MP0003786_premature_aging1.24383236
73MP0002557_abnormal_social/conspecific_i1.23185468
74MP0001672_abnormal_embryogenesis/_devel1.22461684
75MP0005380_embryogenesis_phenotype1.22461684
76MP0002736_abnormal_nociception_after1.21160154
77MP0002019_abnormal_tumor_incidence1.19727246
78MP0002063_abnormal_learning/memory/cond1.19433577
79MP0001293_anophthalmia1.19188758
80MP0000358_abnormal_cell_content/1.17649323
81MP0002067_abnormal_sensory_capabilities1.17003857
82MP0005075_abnormal_melanosome_morpholog1.16921605
83MP0010307_abnormal_tumor_latency1.16832449
84MP0005253_abnormal_eye_physiology1.16573535
85MP0004270_analgesia1.15621292
86MP0002184_abnormal_innervation1.15575799
87MP0000778_abnormal_nervous_system1.14853719
88MP0002163_abnormal_gland_morphology1.14089117
89MP0001919_abnormal_reproductive_system1.14013721
90MP0004859_abnormal_synaptic_plasticity1.13154131
91MP0002132_abnormal_respiratory_system1.11663402
92MP0008932_abnormal_embryonic_tissue1.09862951
93MP0002095_abnormal_skin_pigmentation1.09060747
94MP0001873_stomach_inflammation1.08982912
95MP0003984_embryonic_growth_retardation1.08329591
96MP0002088_abnormal_embryonic_growth/wei1.07082116
97MP0002751_abnormal_autonomic_nervous1.06211751
98MP0002080_prenatal_lethality1.05551827
99MP0001485_abnormal_pinna_reflex1.05537804
100MP0001145_abnormal_male_reproductive1.04816712
101MP0001502_abnormal_circadian_rhythm1.04703262
102MP0000026_abnormal_inner_ear1.04564797
103MP0002938_white_spotting1.02642412
104MP0001963_abnormal_hearing_physiology1.02162660
105MP0000653_abnormal_sex_gland1.01653999
106MP0002084_abnormal_developmental_patter0.99969162
107MP0001764_abnormal_homeostasis0.99499217
108MP0003646_muscle_fatigue0.99399287
109MP0003656_abnormal_erythrocyte_physiolo0.98928886
110MP0002752_abnormal_somatic_nervous0.96278830
111MP0001970_abnormal_pain_threshold0.95693071
112MP0003077_abnormal_cell_cycle0.92993845
113MP0000678_abnormal_parathyroid_gland0.91879404
114MP0003943_abnormal_hepatobiliary_system0.91046841
115MP0001440_abnormal_grooming_behavior0.90676462
116MP0003890_abnormal_embryonic-extraembry0.89266158
117MP0000427_abnormal_hair_cycle0.88351017
118MP0003937_abnormal_limbs/digits/tail_de0.88133098
119MP0000703_abnormal_thymus_morphology0.87208866
120MP0004197_abnormal_fetal_growth/weight/0.86845902
121MP0002085_abnormal_embryonic_tissue0.86518241
122MP0002882_abnormal_neuron_morphology0.85606089
123MP0002160_abnormal_reproductive_system0.85452935
124MP0009333_abnormal_splenocyte_physiolog0.85116342
125MP0002234_abnormal_pharynx_morphology0.84893920
126MP0002876_abnormal_thyroid_physiology0.84421501
127MP0001119_abnormal_female_reproductive0.83297598
128MP0002009_preneoplasia0.83133349
129MP0003763_abnormal_thymus_physiology0.81110654
130MP0005389_reproductive_system_phenotype0.78720306
131MP0004808_abnormal_hematopoietic_stem0.78164667
132MP0002822_catalepsy0.76659594
133MP0003315_abnormal_perineum_morphology0.76334798
134MP0001661_extended_life_span0.76248244
135MP0002229_neurodegeneration0.75985255
136MP0004957_abnormal_blastocyst_morpholog0.75757448
137MP0003183_abnormal_peptide_metabolism0.74937711
138MP0000490_abnormal_crypts_of0.74126318
139MP0002210_abnormal_sex_determination0.74049160
140MP0003567_abnormal_fetal_cardiomyocyte0.72517503
141MP0008260_abnormal_autophagy0.71714651
142MP0001286_abnormal_eye_development0.71079272
143MP0004924_abnormal_behavior0.70217824
144MP0005386_behavior/neurological_phenoty0.70217824
145MP0005395_other_phenotype0.68897942
146MP0003698_abnormal_male_reproductive0.68799749
147MP0001186_pigmentation_phenotype0.68542743
148MP0000689_abnormal_spleen_morphology0.66866526
149MP0003879_abnormal_hair_cell0.66512126
150MP0005410_abnormal_fertilization0.65784194
151MP0000049_abnormal_middle_ear0.65751961
152MP0003938_abnormal_ear_development0.65454316
153MP0002086_abnormal_extraembryonic_tissu0.65251073
154MP0002398_abnormal_bone_marrow0.65069963
155MP0002722_abnormal_immune_system0.63198890
156MP0002161_abnormal_fertility/fecundity0.61498717
157MP0001545_abnormal_hematopoietic_system0.61231822
158MP0005397_hematopoietic_system_phenotyp0.61231822
159MP0003699_abnormal_female_reproductive0.59614835

Predicted human phenotypes

RankGene SetZ-score
1Abnormal ciliary motility (HP:0012262)3.97335154
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.85535045
3Abnormality of cells of the erythroid lineage (HP:0012130)3.80248464
4Abnormal number of erythroid precursors (HP:0012131)3.79313315
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.75721744
6Abnormal respiratory motile cilium physiology (HP:0012261)3.49364841
7Chromsome breakage (HP:0040012)3.33736127
8Abnormal mitochondria in muscle tissue (HP:0008316)3.29252697
9Abnormal respiratory motile cilium morphology (HP:0005938)3.28313953
10Abnormal respiratory epithelium morphology (HP:0012253)3.28313953
11Absent/shortened dynein arms (HP:0200106)3.21949385
12Dynein arm defect of respiratory motile cilia (HP:0012255)3.21949385
13Acute encephalopathy (HP:0006846)3.17143828
14Increased CSF lactate (HP:0002490)3.15109809
15Abnormality of the pons (HP:0007361)3.10854165
16Focal motor seizures (HP:0011153)3.03916997
17Hypoplasia of the pons (HP:0012110)3.02012482
18Hepatocellular necrosis (HP:0001404)2.94983968
19Medial flaring of the eyebrow (HP:0010747)2.90953316
20Lipid accumulation in hepatocytes (HP:0006561)2.90604228
21Duplicated collecting system (HP:0000081)2.89355143
22Pancreatic fibrosis (HP:0100732)2.82762039
23Febrile seizures (HP:0002373)2.80725916
24Abnormality of the renal collecting system (HP:0004742)2.77012902
25Pancreatic cysts (HP:0001737)2.76878686
26Increased serum lactate (HP:0002151)2.76237288
27True hermaphroditism (HP:0010459)2.71456757
28Nephronophthisis (HP:0000090)2.70083907
29Progressive macrocephaly (HP:0004481)2.68488527
30Tubulointerstitial nephritis (HP:0001970)2.67669445
31Abnormal hair whorl (HP:0010721)2.65627552
32Hepatic necrosis (HP:0002605)2.62167472
33Cerebral edema (HP:0002181)2.60264941
34Median cleft lip (HP:0000161)2.60072456
35Gait imbalance (HP:0002141)2.58379089
36Nephrogenic diabetes insipidus (HP:0009806)2.54828636
37Myelodysplasia (HP:0002863)2.52505423
38Congenital primary aphakia (HP:0007707)2.51733307
39Absent thumb (HP:0009777)2.50384133
40Septo-optic dysplasia (HP:0100842)2.47204130
41Small intestinal stenosis (HP:0012848)2.39987671
42Duodenal stenosis (HP:0100867)2.39987671
43Abnormality of alanine metabolism (HP:0010916)2.36588980
44Hyperalaninemia (HP:0003348)2.36588980
45Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.36588980
46Abnormality of midbrain morphology (HP:0002418)2.31889209
47Molar tooth sign on MRI (HP:0002419)2.31889209
48Squamous cell carcinoma (HP:0002860)2.31204586
49Sloping forehead (HP:0000340)2.29413065
50Clubbing of toes (HP:0100760)2.28292729
51Atelectasis (HP:0100750)2.27669449
52Macrocytic anemia (HP:0001972)2.27463558
53Abnormality of DNA repair (HP:0003254)2.27345808
54Patellar aplasia (HP:0006443)2.26974974
55Rhinitis (HP:0012384)2.26350146
56Abnormality of the preputium (HP:0100587)2.22608196
57Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.21921937
58Abnormal protein N-linked glycosylation (HP:0012347)2.21921937
59Abnormal protein glycosylation (HP:0012346)2.21921937
60Abnormal glycosylation (HP:0012345)2.21921937
61Abnormality of the carotid arteries (HP:0005344)2.21745984
62Abnormality of the renal medulla (HP:0100957)2.21293547
63Severe visual impairment (HP:0001141)2.20012436
64Type I transferrin isoform profile (HP:0003642)2.16209959
65Asplenia (HP:0001746)2.15877703
66Upper limb muscle weakness (HP:0003484)2.15800534
67Lactic acidosis (HP:0003128)2.15392313
68Aplasia/Hypoplasia of the patella (HP:0006498)2.15011676
69Epileptic encephalopathy (HP:0200134)2.14521209
70Submucous cleft hard palate (HP:0000176)2.12898095
71Increased intramyocellular lipid droplets (HP:0012240)2.11739417
72Renal Fanconi syndrome (HP:0001994)2.08971544
73Preaxial hand polydactyly (HP:0001177)2.08236753
74Optic nerve hypoplasia (HP:0000609)2.08162230
75Pallor (HP:0000980)2.07948036
76Short thumb (HP:0009778)2.07528832
77Abnormality of the duodenum (HP:0002246)2.05739470
78Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.04100346
79Birth length less than 3rd percentile (HP:0003561)2.04085804
80Severe combined immunodeficiency (HP:0004430)2.03127555
81Reticulocytopenia (HP:0001896)2.03063946
82Abnormality of homocysteine metabolism (HP:0010919)2.00263912
83Homocystinuria (HP:0002156)2.00263912
84Ependymoma (HP:0002888)2.00262171
85Colon cancer (HP:0003003)1.99680836
86Parakeratosis (HP:0001036)1.97441259
87Split foot (HP:0001839)1.97031694
88Pancytopenia (HP:0001876)1.96708387
89Aplasia/Hypoplasia of the fovea (HP:0008060)1.96000770
90Hypoplasia of the fovea (HP:0007750)1.96000770
91Abnormality of the septum pellucidum (HP:0007375)1.94772766
92Abnormality of methionine metabolism (HP:0010901)1.94615592
93Increased hepatocellular lipid droplets (HP:0006565)1.94192381
94Volvulus (HP:0002580)1.94151458
95Protruding tongue (HP:0010808)1.92927146
96Mitochondrial inheritance (HP:0001427)1.92670306
97Triphalangeal thumb (HP:0001199)1.92482118
98Increased muscle lipid content (HP:0009058)1.92126734
99Congenital stationary night blindness (HP:0007642)1.91292467
100Acute necrotizing encephalopathy (HP:0006965)1.91151447
101Multiple enchondromatosis (HP:0005701)1.90416850
102Microvesicular hepatic steatosis (HP:0001414)1.90235930
103Absent rod-and cone-mediated responses on ERG (HP:0007688)1.90106366
104Meckel diverticulum (HP:0002245)1.89729440
105Aganglionic megacolon (HP:0002251)1.88888643
106Cleft eyelid (HP:0000625)1.87727994
107Aplasia/Hypoplasia of the spleen (HP:0010451)1.87664571
108Abnormal number of incisors (HP:0011064)1.86894502
109Genital tract atresia (HP:0001827)1.86408741
110Combined immunodeficiency (HP:0005387)1.85861261
111Aplastic anemia (HP:0001915)1.85728881
112Atonic seizures (HP:0010819)1.85624383
113Neoplasm of the adrenal cortex (HP:0100641)1.85555908
114Absent septum pellucidum (HP:0001331)1.85510663
115Decreased central vision (HP:0007663)1.85426217
116Poor coordination (HP:0002370)1.85062259
117Vaginal atresia (HP:0000148)1.84905806
118Hypothermia (HP:0002045)1.84108353
119Aplasia/Hypoplasia of the lens (HP:0008063)1.83870266
120B lymphocytopenia (HP:0010976)1.83848177
121Impulsivity (HP:0100710)1.83840977
122Congenital sensorineural hearing impairment (HP:0008527)1.83642905
123Aplasia/Hypoplasia of the uvula (HP:0010293)1.83183679
124Abnormal biliary tract physiology (HP:0012439)1.80897056
125Bile duct proliferation (HP:0001408)1.80897056
126Respiratory difficulties (HP:0002880)1.80760435
127Postaxial foot polydactyly (HP:0001830)1.80319572
128Progressive microcephaly (HP:0000253)1.79653324
129Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.79652898
130Abnormality of the ileum (HP:0001549)1.78976933
131Renal agenesis (HP:0000104)1.78688180
132Male pseudohermaphroditism (HP:0000037)1.78558320
133Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.78260517
134Decreased activity of mitochondrial respiratory chain (HP:0008972)1.78260517
135Chronic obstructive pulmonary disease (HP:0006510)1.77879147
136Obstructive lung disease (HP:0006536)1.77879147
137Abnormal rod and cone electroretinograms (HP:0008323)1.77660376
138Attenuation of retinal blood vessels (HP:0007843)1.77379533
139Testicular atrophy (HP:0000029)1.75943090
140Osteomalacia (HP:0002749)1.75584313
141Abnormality of the fovea (HP:0000493)1.75309937
142Abnormality of chromosome stability (HP:0003220)1.74977161
143Abnormality of cochlea (HP:0000375)1.74117406
144Horseshoe kidney (HP:0000085)1.73879300
145Facial cleft (HP:0002006)1.73813290
146Abnormality of renal resorption (HP:0011038)1.73618911
147Abnormality of the labia minora (HP:0012880)1.73347813
148Ectopic kidney (HP:0000086)1.72545057
149Exercise intolerance (HP:0003546)1.71888277
150Abnormality of B cell number (HP:0010975)1.71391109
151Aplasia/hypoplasia of the uterus (HP:0008684)1.71149645
152Cerebral hypomyelination (HP:0006808)1.71131197
153Stomach cancer (HP:0012126)1.70671071
154Absent radius (HP:0003974)1.69914421
155Pendular nystagmus (HP:0012043)1.69649918
156Glioma (HP:0009733)1.69632075
157Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.69453161
158Bilateral microphthalmos (HP:0007633)1.68930022
159Lethargy (HP:0001254)1.68551215
1603-Methylglutaconic aciduria (HP:0003535)1.64920857
161Aplasia/Hypoplasia of the earlobes (HP:0009906)1.63478441
162Optic disc pallor (HP:0000543)1.63121297
163Focal seizures (HP:0007359)1.61075435
164Anencephaly (HP:0002323)1.60714778
165Occipital encephalocele (HP:0002085)1.60086301
166Aplasia involving forearm bones (HP:0009822)1.59377848
167Absent forearm bone (HP:0003953)1.59377848
168Congenital hepatic fibrosis (HP:0002612)1.58145047
169Duplication of thumb phalanx (HP:0009942)1.56256463

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.99846275
2EIF2AK13.77177204
3STK163.56364459
4VRK23.04967423
5SRPK12.67769960
6TNIK2.62139406
7MKNK22.43430311
8ZAK2.40879905
9PNCK2.14481647
10NME22.13002316
11MAP2K72.00941151
12PRPF4B1.92634449
13FRK1.92418763
14AKT31.79827168
15NEK61.79737432
16IRAK41.76924268
17MKNK11.72469590
18VRK11.71020328
19BRSK21.69308363
20NEK11.67405547
21NTRK31.65196011
22IRAK31.62853086
23BUB11.59117915
24NME11.51026414
25MAPK131.48503602
26NUAK11.47920856
27BCKDK1.47359123
28CDK31.47314539
29BMPR1B1.42923488
30BMPR21.38345923
31BRD41.35447385
32PIM21.32926776
33TXK1.31963483
34YES11.31416541
35TNK21.30012501
36MARK11.29554894
37IRAK21.28978478
38TAOK31.27256082
39CCNB11.22719938
40EIF2AK21.19660656
41NEK21.15717471
42TRIM281.11785034
43TLK11.11580562
44EIF2AK31.09134515
45PLK41.08947514
46ADRBK21.06244786
47PASK1.05083038
48TSSK61.04895865
49GRK71.04875714
50INSRR1.00939655
51PDK21.00701302
52WNK41.00520190
53RAF10.96099791
54CDK80.95222507
55MST40.95181706
56GRK10.93156926
57PLK30.91652226
58WEE10.91225982
59TEC0.91133347
60MAPK150.91131765
61MAP3K40.90804586
62BRAF0.88903395
63IRAK10.88534749
64RPS6KB20.88200204
65BRSK10.86703806
66CHEK20.85641925
67CAMK2B0.81540631
68PBK0.81233488
69TTK0.80786870
70TAF10.80148850
71MAP3K140.79182836
72DYRK20.77861679
73OXSR10.76878214
74CDK40.74866697
75EPHA40.74495050
76ALK0.74366035
77CDK120.73831614
78PKN10.73504316
79CDK20.73232222
80BCR0.71675060
81RPS6KA50.71527350
82FES0.70380985
83PLK10.70035870
84ATR0.69309331
85NTRK20.69294995
86RIPK40.68726725
87CSNK1E0.68113330
88DYRK1A0.67921815
89MAP4K20.67296413
90PIM10.66951282
91AURKA0.64645676
92WNK30.63550352
93FLT30.62963190
94ACVR1B0.61577421
95CSNK1A1L0.61293561
96NLK0.60851848
97MAP3K130.59798138
98CSNK1G30.58559407
99CDC70.58327702
100TGFBR10.56479732
101CSNK1G10.56100833
102SCYL20.55787341
103PLK20.54704129
104TESK20.53746668
105KDR0.52842330
106UHMK10.52220991
107SGK20.52172333
108CDK190.51400537
109ATM0.50371327
110PRKCI0.50076723
111PRKCE0.49899792
112DYRK30.49349541
113CHEK10.49077499
114PRKDC0.48137626
115CLK10.47276310
116MAP3K60.46614354
117MAP3K120.46275821
118PINK10.45957262
119STK390.45788086
120MAPKAPK50.45374113
121PRKCG0.45216579
122SIK20.44957565
123WNK10.44951724
124CSNK2A20.42760130
125CSNK2A10.42006975
126CDK70.41936892
127CAMK2D0.41355220
128CDK10.41322048
129AURKB0.39720748
130STK38L0.39668157
131SGK2230.39273884
132SGK4940.39273884
133CAMK2A0.38902575
134CSNK1A10.38580308
135MARK30.36220718
136MAPK140.33442594
137IKBKB0.32277677
138CSNK1D0.30560431
139CAMK1D0.29696634
140GSK3B0.29230834
141CSNK1G20.28301786
142MAP2K20.27405423
143AKT10.27309842
144RPS6KA40.26530260
145RPS6KA10.24362422
146STK40.23904319

Predicted pathways (KEGG)

RankGene SetZ-score
1One carbon pool by folate_Homo sapiens_hsa006702.80983552
2RNA polymerase_Homo sapiens_hsa030202.72097001
3Homologous recombination_Homo sapiens_hsa034402.70841693
4Fanconi anemia pathway_Homo sapiens_hsa034602.59505910
5Protein export_Homo sapiens_hsa030602.56170998
6Nicotine addiction_Homo sapiens_hsa050332.44664729
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.18085689
8Ribosome_Homo sapiens_hsa030102.13415782
9Oxidative phosphorylation_Homo sapiens_hsa001902.04519221
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.04102252
11Mismatch repair_Homo sapiens_hsa034302.02140014
12Phototransduction_Homo sapiens_hsa047441.90499885
13Basal transcription factors_Homo sapiens_hsa030221.88822501
14Spliceosome_Homo sapiens_hsa030401.86256251
15Proteasome_Homo sapiens_hsa030501.86098255
16Nucleotide excision repair_Homo sapiens_hsa034201.78633961
17Selenocompound metabolism_Homo sapiens_hsa004501.74813742
18Non-homologous end-joining_Homo sapiens_hsa034501.68791888
19Collecting duct acid secretion_Homo sapiens_hsa049661.58624814
20Taste transduction_Homo sapiens_hsa047421.57631673
21DNA replication_Homo sapiens_hsa030301.56424840
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.51238287
23Pyrimidine metabolism_Homo sapiens_hsa002401.47072505
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.44687080
25Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.43580590
26Parkinsons disease_Homo sapiens_hsa050121.38138336
27Serotonergic synapse_Homo sapiens_hsa047261.35946810
28Morphine addiction_Homo sapiens_hsa050321.34161869
29RNA degradation_Homo sapiens_hsa030181.33001700
30Huntingtons disease_Homo sapiens_hsa050161.27950635
31Sphingolipid metabolism_Homo sapiens_hsa006001.27369449
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.27101206
33Base excision repair_Homo sapiens_hsa034101.25998570
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.23358251
35Caffeine metabolism_Homo sapiens_hsa002321.21230774
36Purine metabolism_Homo sapiens_hsa002301.17964372
37mRNA surveillance pathway_Homo sapiens_hsa030151.16252261
38Olfactory transduction_Homo sapiens_hsa047401.16191112
39SNARE interactions in vesicular transport_Homo sapiens_hsa041301.15573458
40RNA transport_Homo sapiens_hsa030131.15268169
41Alzheimers disease_Homo sapiens_hsa050101.13212703
42Ether lipid metabolism_Homo sapiens_hsa005651.11056313
43GABAergic synapse_Homo sapiens_hsa047271.09423108
44Glutamatergic synapse_Homo sapiens_hsa047241.08901099
45Propanoate metabolism_Homo sapiens_hsa006401.07730466
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.05082243
47Sulfur relay system_Homo sapiens_hsa041221.04655813
48Circadian entrainment_Homo sapiens_hsa047131.02520462
49Regulation of autophagy_Homo sapiens_hsa041401.02026537
50Synaptic vesicle cycle_Homo sapiens_hsa047211.01088287
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.00201648
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.94474466
53Arachidonic acid metabolism_Homo sapiens_hsa005900.93983038
54Linoleic acid metabolism_Homo sapiens_hsa005910.92055203
55Cell cycle_Homo sapiens_hsa041100.91820991
56Vibrio cholerae infection_Homo sapiens_hsa051100.90262411
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88527701
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88262486
59Maturity onset diabetes of the young_Homo sapiens_hsa049500.87360884
60Autoimmune thyroid disease_Homo sapiens_hsa053200.85356176
61Primary immunodeficiency_Homo sapiens_hsa053400.85018423
62Amphetamine addiction_Homo sapiens_hsa050310.84924677
63Rheumatoid arthritis_Homo sapiens_hsa053230.81220847
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79198878
65Pyruvate metabolism_Homo sapiens_hsa006200.76572096
66Vitamin B6 metabolism_Homo sapiens_hsa007500.75216006
67Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73208222
68Dopaminergic synapse_Homo sapiens_hsa047280.72616968
69Other glycan degradation_Homo sapiens_hsa005110.72267371
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72030964
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69821281
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69529809
73Metabolic pathways_Homo sapiens_hsa011000.69265366
74Insulin secretion_Homo sapiens_hsa049110.69124816
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68300509
76Long-term depression_Homo sapiens_hsa047300.68231149
77Calcium signaling pathway_Homo sapiens_hsa040200.68140864
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65761280
79Biosynthesis of amino acids_Homo sapiens_hsa012300.65526783
80Glutathione metabolism_Homo sapiens_hsa004800.64558403
81Graft-versus-host disease_Homo sapiens_hsa053320.64509275
82Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62191275
83Hematopoietic cell lineage_Homo sapiens_hsa046400.62042074
84Butanoate metabolism_Homo sapiens_hsa006500.59883441
85Cholinergic synapse_Homo sapiens_hsa047250.59622169
86Folate biosynthesis_Homo sapiens_hsa007900.58113604
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57639656
88Epstein-Barr virus infection_Homo sapiens_hsa051690.56395763
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.56319488
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55707821
91Lysine degradation_Homo sapiens_hsa003100.54354583
92Intestinal immune network for IgA production_Homo sapiens_hsa046720.53777872
93Allograft rejection_Homo sapiens_hsa053300.53095530
94Alcoholism_Homo sapiens_hsa050340.52502685
95Asthma_Homo sapiens_hsa053100.52327712
96Nitrogen metabolism_Homo sapiens_hsa009100.50655266
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.50280900
98Cocaine addiction_Homo sapiens_hsa050300.49791964
99Type I diabetes mellitus_Homo sapiens_hsa049400.48661544
100Pancreatic secretion_Homo sapiens_hsa049720.47642138
101Long-term potentiation_Homo sapiens_hsa047200.47382648
102p53 signaling pathway_Homo sapiens_hsa041150.46728125
103Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.46385817
104Steroid biosynthesis_Homo sapiens_hsa001000.45884363
105Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45494906
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45426487
107Peroxisome_Homo sapiens_hsa041460.45385651
108Drug metabolism - other enzymes_Homo sapiens_hsa009830.44343750
109Carbon metabolism_Homo sapiens_hsa012000.43937779
110Axon guidance_Homo sapiens_hsa043600.41867818
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.40669353
112Salivary secretion_Homo sapiens_hsa049700.40600162
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39331519
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38542460
115Circadian rhythm_Homo sapiens_hsa047100.37957450
116Renin secretion_Homo sapiens_hsa049240.35851385
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35585641
118Cardiac muscle contraction_Homo sapiens_hsa042600.35337502
119Wnt signaling pathway_Homo sapiens_hsa043100.34042240
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.33484160
121Tryptophan metabolism_Homo sapiens_hsa003800.33343081
122T cell receptor signaling pathway_Homo sapiens_hsa046600.33025763
1232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.32970493
124Oocyte meiosis_Homo sapiens_hsa041140.32931650
125N-Glycan biosynthesis_Homo sapiens_hsa005100.32263957
126NOD-like receptor signaling pathway_Homo sapiens_hsa046210.31633373
127Systemic lupus erythematosus_Homo sapiens_hsa053220.30630806
128Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29931630
129Ras signaling pathway_Homo sapiens_hsa040140.29516737
130cAMP signaling pathway_Homo sapiens_hsa040240.29416844
131Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29222181
132Herpes simplex infection_Homo sapiens_hsa051680.28537446
133Fatty acid metabolism_Homo sapiens_hsa012120.24955355
134Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24619432
135Chemical carcinogenesis_Homo sapiens_hsa052040.24070712
136Viral carcinogenesis_Homo sapiens_hsa052030.22985109
137Transcriptional misregulation in cancer_Homo sapiens_hsa052020.20946162
138Vitamin digestion and absorption_Homo sapiens_hsa049770.20643423
139Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20246129
140Fatty acid elongation_Homo sapiens_hsa000620.20231636
141Pentose and glucuronate interconversions_Homo sapiens_hsa000400.16075086
142Steroid hormone biosynthesis_Homo sapiens_hsa001400.13440483
143Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.10026216
144Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.07856924
145Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.06117287
146Fructose and mannose metabolism_Homo sapiens_hsa000510.04831269
147Glycerolipid metabolism_Homo sapiens_hsa005610.04621385

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