DDX59

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)9.94236294
2transcription from mitochondrial promoter (GO:0006390)7.66991446
3regulation of cytokine production involved in inflammatory response (GO:1900015)7.54919346
4proline metabolic process (GO:0006560)7.47511102
5embryonic process involved in female pregnancy (GO:0060136)7.22020830
6replication fork processing (GO:0031297)7.19420546
7positive regulation of protein homooligomerization (GO:0032464)6.37172126
8DNA deamination (GO:0045006)6.31360109
9maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)6.03464252
10oxidative demethylation (GO:0070989)5.84388044
11regulation of integrin activation (GO:0033623)5.83058208
12establishment of apical/basal cell polarity (GO:0035089)5.69584739
13regulation of protein homooligomerization (GO:0032462)5.64539632
14somatic hypermutation of immunoglobulin genes (GO:0016446)5.55436281
15somatic diversification of immune receptors via somatic mutation (GO:0002566)5.55436281
16mitochondrial DNA metabolic process (GO:0032042)5.44681522
17DNA strand renaturation (GO:0000733)5.41981501
18mitotic G1 DNA damage checkpoint (GO:0031571)4.95559328
19establishment of monopolar cell polarity (GO:0061162)4.93906327
20establishment or maintenance of monopolar cell polarity (GO:0061339)4.93906327
21poly(A)+ mRNA export from nucleus (GO:0016973)4.90298249
22viral mRNA export from host cell nucleus (GO:0046784)4.89730416
23regulation of interleukin-6 biosynthetic process (GO:0045408)4.75613575
24spliceosomal tri-snRNP complex assembly (GO:0000244)4.70760493
25regulation of interleukin-12 biosynthetic process (GO:0045075)4.65792086
26negative regulation of JAK-STAT cascade (GO:0046426)4.58919320
27formation of translation preinitiation complex (GO:0001731)4.55545590
28regulation of translational fidelity (GO:0006450)4.41475007
29positive regulation of osteoclast differentiation (GO:0045672)4.40140694
30telomere maintenance via semi-conservative replication (GO:0032201)4.37063164
31mitotic G1/S transition checkpoint (GO:0044819)4.33628004
32G1 DNA damage checkpoint (GO:0044783)4.32716266
33base-excision repair (GO:0006284)4.32105043
34mRNA cleavage (GO:0006379)4.27977789
35embryonic placenta development (GO:0001892)4.27187674
36negative regulation of cell cycle arrest (GO:0071157)4.18763252
37cellular response to ATP (GO:0071318)4.17969434
38establishment of protein localization to mitochondrial membrane (GO:0090151)4.13208994
39positive regulation of mitotic sister chromatid separation (GO:1901970)4.13129391
40positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.13129391
41positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.13129391
42regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)4.11537520
43nucleotide-excision repair, DNA gap filling (GO:0006297)4.09300204
44DNA integration (GO:0015074)4.04931700
45negative regulation of fatty acid biosynthetic process (GO:0045717)4.02419081
46non-recombinational repair (GO:0000726)3.95425099
47double-strand break repair via nonhomologous end joining (GO:0006303)3.95425099
48meiotic chromosome segregation (GO:0045132)3.94759451
49regulation of sister chromatid cohesion (GO:0007063)3.93154951
50piRNA metabolic process (GO:0034587)3.92432554
51glutamine family amino acid biosynthetic process (GO:0009084)3.92039870
52negative regulation of protein oligomerization (GO:0032460)3.91436126
53DNA double-strand break processing (GO:0000729)3.90321555
54dosage compensation (GO:0007549)3.83136905
55regulation of double-strand break repair via homologous recombination (GO:0010569)3.78459198
56negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.78297524
57base-excision repair, AP site formation (GO:0006285)3.77980401
58positive regulation of protein oligomerization (GO:0032461)3.76653454
59positive regulation of developmental pigmentation (GO:0048087)3.74505593
60DNA strand elongation involved in DNA replication (GO:0006271)3.71792424
61pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.71760779
62centriole replication (GO:0007099)3.70996551
63DNA topological change (GO:0006265)3.67046735
64cellular response to zinc ion (GO:0071294)3.66199159
65embryonic camera-type eye development (GO:0031076)3.65504623
66regulation of protein oligomerization (GO:0032459)3.62437986
67DNA ligation (GO:0006266)3.62036573
68telomere maintenance via recombination (GO:0000722)3.60052101
69positive regulation by host of viral transcription (GO:0043923)3.59311943
70maturation of 5.8S rRNA (GO:0000460)3.57909541
71mitochondrial RNA metabolic process (GO:0000959)3.54223125
72histone H4-K12 acetylation (GO:0043983)3.53106824
73regulation of interleukin-8 biosynthetic process (GO:0045414)3.51979315
74alpha-beta T cell differentiation (GO:0046632)3.51850492
75regulation of immunoglobulin secretion (GO:0051023)3.49601478
76negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.49572120
77regulation of RNA export from nucleus (GO:0046831)3.49414949
78DNA strand elongation (GO:0022616)3.48992159
79termination of RNA polymerase II transcription (GO:0006369)3.43592580
80signal peptide processing (GO:0006465)3.43577182
81negative regulation of Ras GTPase activity (GO:0034261)3.42773086
82regulation of double-strand break repair (GO:2000779)3.42180353
83kinetochore assembly (GO:0051382)3.39578025
84negative regulation of mRNA processing (GO:0050686)3.39560689
85regulation of DNA damage checkpoint (GO:2000001)3.39509292
86positive regulation of DNA repair (GO:0045739)3.36535810
87T-helper 1 type immune response (GO:0042088)3.31893010
88convergent extension (GO:0060026)3.31580175
89face development (GO:0060324)3.31411065
90positive regulation of T cell cytokine production (GO:0002726)3.31176868
91positive regulation of chromosome segregation (GO:0051984)3.28466108
92regulation of meiosis I (GO:0060631)3.28256375
93apoptotic process involved in morphogenesis (GO:0060561)3.27598585
94negative regulation of T-helper cell differentiation (GO:0045623)3.25456894
95negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.25456894
96trophectodermal cell differentiation (GO:0001829)3.25426685
97regulation of posttranscriptional gene silencing (GO:0060147)3.24553428
98regulation of gene silencing by miRNA (GO:0060964)3.24553428
99regulation of gene silencing by RNA (GO:0060966)3.24553428
100negative regulation of thymocyte apoptotic process (GO:0070244)3.24138108
101nodal signaling pathway (GO:0038092)3.23321093
102glial cell migration (GO:0008347)3.23068001
103GDP-mannose metabolic process (GO:0019673)3.23040020
104DNA demethylation (GO:0080111)3.21697755
105mitotic sister chromatid segregation (GO:0000070)3.20674824
106positive regulation of defense response to virus by host (GO:0002230)3.18847536
107alpha-beta T cell activation (GO:0046631)3.17106042
108cytokine biosynthetic process (GO:0042089)3.17013922
109labyrinthine layer development (GO:0060711)3.16682209
110cullin deneddylation (GO:0010388)3.14946927
111protein K11-linked deubiquitination (GO:0035871)3.14678029
112postreplication repair (GO:0006301)3.10772773
113mitotic recombination (GO:0006312)3.06570969
114telomere maintenance via telomere lengthening (GO:0010833)3.06227000
115pyrimidine nucleotide catabolic process (GO:0006244)3.05483454
116resolution of meiotic recombination intermediates (GO:0000712)3.04749148
117anatomical structure regression (GO:0060033)3.01459703
118synapsis (GO:0007129)2.98023811
119regulation of thymocyte apoptotic process (GO:0070243)2.97621393
120mitochondrial DNA replication (GO:0006264)2.96304135
121myeloid dendritic cell differentiation (GO:0043011)2.95361566
122DNA catabolic process, exonucleolytic (GO:0000738)2.94919408
123negative regulation of DNA-dependent DNA replication (GO:2000104)2.93582717
124mitotic nuclear envelope reassembly (GO:0007084)2.92490679
125nuclear envelope reassembly (GO:0031468)2.92490679
126kinetochore organization (GO:0051383)2.92306415
127response to interleukin-15 (GO:0070672)2.90720171
128regulation of cell size (GO:0008361)2.90226098
129regulation of B cell receptor signaling pathway (GO:0050855)2.88762445
130positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.84983638
131cytidine deamination (GO:0009972)2.84040965
132cytidine metabolic process (GO:0046087)2.84040965
133cytidine catabolic process (GO:0006216)2.84040965
134epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.82386777
135DNA methylation involved in gamete generation (GO:0043046)2.79769880
136male meiosis I (GO:0007141)2.79129305
137interleukin-1-mediated signaling pathway (GO:0070498)2.75079061
138cytokine metabolic process (GO:0042107)2.75032500
139positive regulation of prostaglandin secretion (GO:0032308)2.74118407
140myeloid dendritic cell activation (GO:0001773)2.69672357
141negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.69231880
142cellular response to interleukin-15 (GO:0071350)2.69051693
143nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.67906875
144positive regulation of histone H3-K4 methylation (GO:0051571)2.67883926
145I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.63179623
146negative regulation of alpha-beta T cell differentiation (GO:0046639)2.62104965
147regulation of DNA endoreduplication (GO:0032875)2.61526435
148indole-containing compound catabolic process (GO:0042436)2.56224941
149indolalkylamine catabolic process (GO:0046218)2.56224941
150tryptophan catabolic process (GO:0006569)2.56224941
151detection of light stimulus involved in visual perception (GO:0050908)2.56170258
152detection of light stimulus involved in sensory perception (GO:0050962)2.56170258
153positive regulation of interleukin-2 production (GO:0032743)2.55034313
154T-helper cell differentiation (GO:0042093)2.54559944
155CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.54559944
156thrombin receptor signaling pathway (GO:0070493)2.54242936
157negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.53424706
158pyrimidine ribonucleoside catabolic process (GO:0046133)2.53101420
159positive regulation of alpha-beta T cell proliferation (GO:0046641)2.52734829
160meiotic cell cycle (GO:0051321)2.51637013
161multicellular organism reproduction (GO:0032504)2.51282994
162somatic diversification of immunoglobulins (GO:0016445)2.51032773
163RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.50671252
164positive regulation of gamma-delta T cell activation (GO:0046645)2.50461108
165kynurenine metabolic process (GO:0070189)2.50318722
166CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.50296381
167response to xenobiotic stimulus (GO:0009410)2.48367330
168reciprocal meiotic recombination (GO:0007131)2.46507218
169reciprocal DNA recombination (GO:0035825)2.46507218
170somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.45771670
171somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.45771670
172isotype switching (GO:0045190)2.45771670
173positive regulation of transcription regulatory region DNA binding (GO:2000679)2.44432851
174positive regulation of interleukin-1 beta secretion (GO:0050718)2.44214581
175positive regulation of granulocyte differentiation (GO:0030854)2.42529734
176neutrophil activation involved in immune response (GO:0002283)2.42523080
177regulation of interleukin-2 production (GO:0032663)2.42257546
178T cell differentiation involved in immune response (GO:0002292)2.40247982
179alpha-beta T cell differentiation involved in immune response (GO:0002293)2.40247982
180alpha-beta T cell activation involved in immune response (GO:0002287)2.40247982
181purine-containing compound salvage (GO:0043101)2.39260017
182negative regulation of adaptive immune response (GO:0002820)2.39139699
183centriole assembly (GO:0098534)2.38677223
184adenosine metabolic process (GO:0046085)2.38220250
185regulation of fibroblast apoptotic process (GO:2000269)2.38068642
186platelet dense granule organization (GO:0060155)2.38004090
187lactate metabolic process (GO:0006089)2.37219458
188negative regulation of cell killing (GO:0031342)2.37085844
189negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.37085844
190negative regulation of interleukin-12 production (GO:0032695)2.36691428
191gene silencing by RNA (GO:0031047)2.36658466
192positive regulation of myeloid leukocyte differentiation (GO:0002763)2.34926119
193recombinational repair (GO:0000725)2.34201871
194regulation of T cell cytokine production (GO:0002724)2.34039552

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.89480797
2E2F7_22180533_ChIP-Seq_HELA_Human3.78296559
3SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.31749697
4ZNF274_21170338_ChIP-Seq_K562_Hela3.22740150
5FLI1_27457419_Chip-Seq_LIVER_Mouse3.17344827
6ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.13392859
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.12432261
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.07523570
9KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.07147539
10KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.07147539
11KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.07147539
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.99600978
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.86127691
14NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.61937442
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.54953019
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.50554399
17NOTCH1_21737748_ChIP-Seq_TLL_Human2.50020061
18PCGF2_27294783_Chip-Seq_ESCs_Mouse2.47787429
19IGF1R_20145208_ChIP-Seq_DFB_Human2.46300550
20SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.45891860
21SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.44563558
22BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.41950520
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.41739607
24VDR_22108803_ChIP-Seq_LS180_Human2.33692909
25NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.32077890
26* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.30916808
27MYC_18358816_ChIP-ChIP_MESCs_Mouse2.29008112
28DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.27306485
29STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.24367474
30* SALL1_21062744_ChIP-ChIP_HESCs_Human2.20486494
31KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.16500002
32VDR_21846776_ChIP-Seq_THP-1_Human2.15381175
33POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.14052465
34KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.14035663
35POU5F1_16518401_ChIP-PET_MESCs_Mouse2.09156646
36IRF8_21731497_ChIP-ChIP_J774_Mouse2.08051341
37TCF3_18692474_ChIP-Seq_MESCs_Mouse2.06341624
38POU3F2_20337985_ChIP-ChIP_501MEL_Human2.05253359
39IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.04225595
40MYC_19030024_ChIP-ChIP_MESCs_Mouse2.03400032
41GABP_17652178_ChIP-ChIP_JURKAT_Human2.01627720
42FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.99396101
43VDR_23849224_ChIP-Seq_CD4+_Human1.91880713
44ELK1_19687146_ChIP-ChIP_HELA_Human1.89811974
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88351465
46NANOG_21062744_ChIP-ChIP_HESCs_Human1.86803385
47RUNX_20019798_ChIP-Seq_JUKART_Human1.86312674
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.83944559
49NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.83169153
50SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.82940068
51TCF3_18692474_ChIP-Seq_MEFs_Mouse1.82574214
52EST1_17652178_ChIP-ChIP_JURKAT_Human1.78821318
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.77939860
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.77931235
55JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.77500189
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75228136
57* EZH2_27294783_Chip-Seq_NPCs_Mouse1.74775989
58* NFE2_27457419_Chip-Seq_LIVER_Mouse1.73784963
59TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73387655
60HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.72612694
61ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.71502660
62* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.70344746
63EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.69603092
64CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.69522628
65CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.69463046
66PU.1_20513432_ChIP-Seq_Bcells_Mouse1.68059853
67* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.64731389
68THAP11_20581084_ChIP-Seq_MESCs_Mouse1.64587429
69ER_23166858_ChIP-Seq_MCF-7_Human1.63068039
70E2F4_17652178_ChIP-ChIP_JURKAT_Human1.62318184
71MYC_22102868_ChIP-Seq_BL_Human1.60938933
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.60889284
73FUS_26573619_Chip-Seq_HEK293_Human1.59625327
74LXR_22292898_ChIP-Seq_THP-1_Human1.59569186
75MYCN_18555785_ChIP-Seq_MESCs_Mouse1.58424204
76KLF4_18555785_ChIP-Seq_MESCs_Mouse1.57415250
77NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.55815227
78MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55538286
79CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.53874423
80EWS_26573619_Chip-Seq_HEK293_Human1.52127706
81ERG_21242973_ChIP-ChIP_JURKAT_Human1.50396064
82CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.48255823
83* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.47798452
84NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.46166199
85* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.45729593
86YY1_21170310_ChIP-Seq_MESCs_Mouse1.45627206
87IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.43519881
88STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.43482431
89DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.42729214
90GATA3_26560356_Chip-Seq_TH2_Human1.42053840
91POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.41155336
92SOX2_18555785_ChIP-Seq_MESCs_Mouse1.40957285
93POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.39958955
94ETS1_20019798_ChIP-Seq_JURKAT_Human1.39723108
95* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37227042
96TET1_21451524_ChIP-Seq_MESCs_Mouse1.36158916
97BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.36017544
98GABP_19822575_ChIP-Seq_HepG2_Human1.35941257
99ESR1_15608294_ChIP-ChIP_MCF-7_Human1.35048593
100IRF1_19129219_ChIP-ChIP_H3396_Human1.34483639
101MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.33604608
102DCP1A_22483619_ChIP-Seq_HELA_Human1.33387810
103* CRX_20693478_ChIP-Seq_RETINA_Mouse1.32736069
104ELF1_17652178_ChIP-ChIP_JURKAT_Human1.32392294
105* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.31837568
106GBX2_23144817_ChIP-Seq_PC3_Human1.31715608
107PADI4_21655091_ChIP-ChIP_MCF-7_Human1.31567164
108ZNF263_19887448_ChIP-Seq_K562_Human1.30984390
109MYB_26560356_Chip-Seq_TH2_Human1.29959437
110ZFP57_27257070_Chip-Seq_ESCs_Mouse1.29946626
111PCGF2_27294783_Chip-Seq_NPCs_Mouse1.29033820
112SOX2_18692474_ChIP-Seq_MESCs_Mouse1.28941816
113EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27906804
114ZFP281_18757296_ChIP-ChIP_E14_Mouse1.27894675
115TP53_22573176_ChIP-Seq_HFKS_Human1.27225296
116* FOXP3_21729870_ChIP-Seq_TREG_Human1.26414554
117SOX2_18692474_ChIP-Seq_MEFs_Mouse1.25474182
118IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25414962
119CBP_20019798_ChIP-Seq_JUKART_Human1.25414962
120* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.25228223
121NANOG_18692474_ChIP-Seq_MESCs_Mouse1.24709104
122ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24423699
123PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24323675
124* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.24292288
125CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.22684008
126P300_19829295_ChIP-Seq_ESCs_Human1.22621176
127PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22608628
128PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.22273258
129CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.21811403
130ETS1_21867929_ChIP-Seq_TH2_Mouse1.18131679
131SOX2_19829295_ChIP-Seq_ESCs_Human1.17866981
132NANOG_19829295_ChIP-Seq_ESCs_Human1.17866981
133OCT4_18692474_ChIP-Seq_MEFs_Mouse1.17808926
134XRN2_22483619_ChIP-Seq_HELA_Human1.17034101
135ZFP281_27345836_Chip-Seq_ESCs_Mouse1.16998262
136* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.16944620
137HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15873149
138* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.15630247
139TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15538488
140E2F1_21310950_ChIP-Seq_MCF-7_Human1.15048602
141RXRA_24833708_ChIP-Seq_LIVER_Mouse1.14933592
142HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.14859774
143* RACK7_27058665_Chip-Seq_MCF-7_Human1.13995381
144EGR1_23403033_ChIP-Seq_LIVER_Mouse1.13833999
145RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.13814354
146FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13697982
147FOXA1_25329375_ChIP-Seq_VCAP_Human1.13697982
148UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13132031
149MYC_18940864_ChIP-ChIP_HL60_Human1.12846746
150TP63_19390658_ChIP-ChIP_HaCaT_Human1.12550298
151EZH2_22144423_ChIP-Seq_EOC_Human1.11479888
152* KDM5A_27292631_Chip-Seq_BREAST_Human1.11138491
153HTT_18923047_ChIP-ChIP_STHdh_Human1.09423111
154* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09040481
155SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09024279
156* E2F1_18555785_Chip-Seq_ESCs_Mouse1.08945500
157RARB_24833708_ChIP-Seq_LIVER_Mouse1.08534011
158TTF2_22483619_ChIP-Seq_HELA_Human1.08433059
159* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07664515
160GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06984832
161TCF4_23295773_ChIP-Seq_U87_Human1.06593479
162PRDM14_20953172_ChIP-Seq_ESCs_Human1.05199884
163PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.04794349
164* NANOG_18555785_Chip-Seq_ESCs_Mouse1.04018089
165AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03881183
166TFEB_21752829_ChIP-Seq_HELA_Human1.02874452
167NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.02559660
168GATA3_27048872_Chip-Seq_THYMUS_Human1.02140243
169* P53_22387025_ChIP-Seq_ESCs_Mouse1.01941015
170* STAT3_18555785_Chip-Seq_ESCs_Mouse1.01645176
171NANOG_16518401_ChIP-PET_MESCs_Mouse1.01443789
172TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.00689338
173* P300_18555785_Chip-Seq_ESCs_Mouse1.00595897
174STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.00358277
175KAP1_27257070_Chip-Seq_ESCs_Mouse1.00267543
176* STAT3_23295773_ChIP-Seq_U87_Human1.00249592
177STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00235118
178* OCT4_18555785_Chip-Seq_ESCs_Mouse1.00199785
179KDM2B_26808549_Chip-Seq_DND41_Human0.99921267
180IRF8_27001747_Chip-Seq_BMDM_Mouse0.99803125
181SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98909819
182* CTCF_18555785_Chip-Seq_ESCs_Mouse0.98525937
183* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98132358
184CTCF_21964334_ChIP-Seq_BJAB-B_Human0.98122846
185NANOG_18692474_ChIP-Seq_MEFs_Mouse0.98032627
186* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.98027997
187SPI1_26923725_Chip-Seq_HPCs_Mouse0.97591324
188STAT4_19710469_ChIP-ChIP_TH1__Mouse0.97054456
189CDX2_22108803_ChIP-Seq_LS180_Human0.96789494
190RARA_24833708_ChIP-Seq_LIVER_Mouse0.96735906
191FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96700566
192* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.96208931
193SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.96080873
194HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.95900260
195BP1_19119308_ChIP-ChIP_Hs578T_Human0.95458744
196CTBP1_25329375_ChIP-Seq_LNCAP_Human0.95223472
197* NMYC_18555785_Chip-Seq_ESCs_Mouse0.94532616
198* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.94222538

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.29025503
2MP0010030_abnormal_orbit_morphology4.26882870
3MP0005171_absent_coat_pigmentation4.07085996
4MP0009278_abnormal_bone_marrow3.98296752
5MP0004233_abnormal_muscle_weight3.43122767
6MP0010094_abnormal_chromosome_stability3.10267345
7MP0005387_immune_system_phenotype3.00362910
8MP0001790_abnormal_immune_system3.00362910
9MP0009785_altered_susceptibility_to2.94061951
10MP0005671_abnormal_response_to2.85881426
11MP0003436_decreased_susceptibility_to2.81659147
12MP0002009_preneoplasia2.69094595
13MP0003724_increased_susceptibility_to2.68965954
14MP0001835_abnormal_antigen_presentation2.57687667
15MP0003195_calcinosis2.52491995
16MP0004957_abnormal_blastocyst_morpholog2.47054265
17MP0002138_abnormal_hepatobiliary_system2.38421561
18MP0001800_abnormal_humoral_immune2.32247863
19MP0003890_abnormal_embryonic-extraembry2.31453800
20MP0002148_abnormal_hypersensitivity_rea2.30876004
21MP0004133_heterotaxia2.19915533
22MP0003111_abnormal_nucleus_morphology2.18741889
23MP0008995_early_reproductive_senescence2.16234373
24MP0008058_abnormal_DNA_repair2.14503082
25MP0002095_abnormal_skin_pigmentation2.14354917
26MP0003786_premature_aging2.13896501
27MP0002653_abnormal_ependyma_morphology2.10090521
28MP0000569_abnormal_digit_pigmentation2.08104314
29MP0006072_abnormal_retinal_apoptosis2.08035286
30MP0003283_abnormal_digestive_organ2.04567814
31MP0005397_hematopoietic_system_phenotyp2.02958878
32MP0001545_abnormal_hematopoietic_system2.02958878
33MP0005000_abnormal_immune_tolerance2.01659800
34MP0002933_joint_inflammation2.01221629
35MP0002723_abnormal_immune_serum2.01110225
36MP0000372_irregular_coat_pigmentation1.99737863
37MP0002249_abnormal_larynx_morphology1.99589781
38MP0008877_abnormal_DNA_methylation1.90723864
39MP0003119_abnormal_digestive_system1.89565143
40MP0008875_abnormal_xenobiotic_pharmacok1.87928428
41MP0002163_abnormal_gland_morphology1.87411999
42MP0002452_abnormal_antigen_presenting1.87166257
43MP0003646_muscle_fatigue1.86213065
44MP0003077_abnormal_cell_cycle1.84454514
45MP0005174_abnormal_tail_pigmentation1.78901455
46MP0008932_abnormal_embryonic_tissue1.78770670
47MP0010352_gastrointestinal_tract_polyps1.77685581
48MP0003693_abnormal_embryo_hatching1.76919661
49MP0002837_dystrophic_cardiac_calcinosis1.76918984
50MP0002084_abnormal_developmental_patter1.76607320
51MP0001697_abnormal_embryo_size1.76527656
52MP0001293_anophthalmia1.75356963
53MP0001764_abnormal_homeostasis1.74570506
54MP0002086_abnormal_extraembryonic_tissu1.73116325
55MP0002282_abnormal_trachea_morphology1.71944468
56MP0003763_abnormal_thymus_physiology1.69989137
57MP0010155_abnormal_intestine_physiology1.67176596
58MP0002420_abnormal_adaptive_immunity1.66681782
59MP0005076_abnormal_cell_differentiation1.66136120
60MP0001819_abnormal_immune_cell1.65919532
61MP0002085_abnormal_embryonic_tissue1.63428081
62MP0005310_abnormal_salivary_gland1.62463573
63MP0003453_abnormal_keratinocyte_physiol1.61437984
64MP0006292_abnormal_olfactory_placode1.56158358
65MP0004197_abnormal_fetal_growth/weight/1.54129979
66MP0001853_heart_inflammation1.52066690
67MP0001986_abnormal_taste_sensitivity1.48661210
68MP0005380_embryogenesis_phenotype1.46154095
69MP0001672_abnormal_embryogenesis/_devel1.46154095
70MP0000427_abnormal_hair_cycle1.42998246
71MP0000371_diluted_coat_color1.42629947
72MP0000579_abnormal_nail_morphology1.42591611
73MP0000015_abnormal_ear_pigmentation1.42185776
74MP0002269_muscular_atrophy1.41607983
75MP0005025_abnormal_response_to1.40233405
76MP0005646_abnormal_pituitary_gland1.39814757
77MP0000490_abnormal_crypts_of1.38676758
78MP0000350_abnormal_cell_proliferation1.38462172
79MP0002277_abnormal_respiratory_mucosa1.38273922
80MP0003567_abnormal_fetal_cardiomyocyte1.35690801
81MP0001730_embryonic_growth_arrest1.35242560
82MP0003252_abnormal_bile_duct1.34322862
83MP0003172_abnormal_lysosome_physiology1.33397864
84MP0005075_abnormal_melanosome_morpholog1.33072394
85MP0002419_abnormal_innate_immunity1.32465417
86MP0005379_endocrine/exocrine_gland_phen1.30434218
87MP0000689_abnormal_spleen_morphology1.29909055
88MP0004142_abnormal_muscle_tone1.29258011
89MP0000716_abnormal_immune_system1.23774850
90MP0009764_decreased_sensitivity_to1.22926440
91MP0002722_abnormal_immune_system1.22688208
92MP0003718_maternal_effect1.20905078
93MP0001845_abnormal_inflammatory_respons1.20409958
94MP0001533_abnormal_skeleton_physiology1.20092059
95MP0002398_abnormal_bone_marrow1.17453443
96MP0000470_abnormal_stomach_morphology1.15211687
97MP0002111_abnormal_tail_morphology1.14412010
98MP0003984_embryonic_growth_retardation1.13859634
99MP0002080_prenatal_lethality1.13234548
100MP0008469_abnormal_protein_level1.12587610
101MP0005058_abnormal_lysosome_morphology1.12554892
102MP0001873_stomach_inflammation1.12436656
103MP0002019_abnormal_tumor_incidence1.10230143
104MP0005551_abnormal_eye_electrophysiolog1.09549145
105MP0000703_abnormal_thymus_morphology1.08841910
106MP0000639_abnormal_adrenal_gland1.08061849
107MP0002088_abnormal_embryonic_growth/wei1.07726480
108MP0006082_CNS_inflammation1.04734879
109MP0002876_abnormal_thyroid_physiology1.04044118
110MP0009333_abnormal_splenocyte_physiolog1.03617562
111MP0003866_abnormal_defecation1.01918056
112MP0002932_abnormal_joint_morphology1.00746164
113MP0010307_abnormal_tumor_latency1.00316536
114MP0005389_reproductive_system_phenotype0.99128503
115MP0002075_abnormal_coat/hair_pigmentati0.98831319
116MP0001340_abnormal_eyelid_morphology0.98100415
117MP0003806_abnormal_nucleotide_metabolis0.96987546
118MP0002254_reproductive_system_inflammat0.96570426
119MP0005266_abnormal_metabolism0.96415311
120MP0002796_impaired_skin_barrier0.93523076
121MP0003755_abnormal_palate_morphology0.93132171
122MP0002429_abnormal_blood_cell0.91859766
123MP0002693_abnormal_pancreas_physiology0.91444493
124MP0000462_abnormal_digestive_system0.91158692
125MP0001929_abnormal_gametogenesis0.90625150
126MP0008873_increased_physiological_sensi0.90059985
127MP0003935_abnormal_craniofacial_develop0.89233457
128MP0005319_abnormal_enzyme/_coenzyme0.89048316
129MP0008789_abnormal_olfactory_epithelium0.88452986
130MP0002114_abnormal_axial_skeleton0.88209163
131MP0000762_abnormal_tongue_morphology0.87950867
132MP0000383_abnormal_hair_follicle0.87909105
133MP0004381_abnormal_hair_follicle0.87057152
134MP0001186_pigmentation_phenotype0.86114430
135MP0004264_abnormal_extraembryonic_tissu0.85521708
136MP0003137_abnormal_impulse_conducting0.85399000
137MP0000313_abnormal_cell_death0.84359915
138MP0001529_abnormal_vocalization0.84170377
139MP0002928_abnormal_bile_duct0.83696786
140MP0008872_abnormal_physiological_respon0.83661513
141MP0009115_abnormal_fat_cell0.81165885
142MP0003787_abnormal_imprinting0.81116018
143MP0001145_abnormal_male_reproductive0.80052488
144MP0003943_abnormal_hepatobiliary_system0.79205373
145MP0002116_abnormal_craniofacial_bone0.79090599
146MP0005501_abnormal_skin_physiology0.78219636
147MP0004043_abnormal_pH_regulation0.78019825
148MP0002160_abnormal_reproductive_system0.77915959
149MP0000647_abnormal_sebaceous_gland0.77163442
150MP0000653_abnormal_sex_gland0.76549363
151MP0001324_abnormal_eye_pigmentation0.75962160
152MP0008775_abnormal_heart_ventricle0.75359592
153MP0010678_abnormal_skin_adnexa0.74919955
154MP0000432_abnormal_head_morphology0.74565069
155MP0005187_abnormal_penis_morphology0.74380027
156MP0005330_cardiomyopathy0.74021240
157MP0002332_abnormal_exercise_endurance0.73797523
158MP0000631_abnormal_neuroendocrine_gland0.73164537
159MP0001919_abnormal_reproductive_system0.72859979
160MP0003828_pulmonary_edema0.72550033
161MP0005645_abnormal_hypothalamus_physiol0.71283937
162MP0002060_abnormal_skin_morphology0.71040182
163MP0005508_abnormal_skeleton_morphology0.70468702
164MP0003045_fibrosis0.69984913
165MP0005253_abnormal_eye_physiology0.69515530
166MP0010630_abnormal_cardiac_muscle0.68172297
167MP0005395_other_phenotype0.67984261
168MP0001765_abnormal_ion_homeostasis0.67617107
169MP0002168_other_aberrant_phenotype0.66771537
170MP0000685_abnormal_immune_system0.64533012
171MP0005023_abnormal_wound_healing0.63911480
172MP0008007_abnormal_cellular_replicative0.63528169
173MP0002970_abnormal_white_adipose0.63232312
174MP0005391_vision/eye_phenotype0.63226121
175MP0005085_abnormal_gallbladder_physiolo0.62520938
176MP0003656_abnormal_erythrocyte_physiolo0.62460736
177MP0002405_respiratory_system_inflammati0.62430979
178MP0009053_abnormal_anal_canal0.61224156
179MP0004019_abnormal_vitamin_homeostasis0.61164720
180MP0002210_abnormal_sex_determination0.60838225
181MP0003699_abnormal_female_reproductive0.59484926

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)5.72385397
2Concave nail (HP:0001598)5.21203838
3Facial hemangioma (HP:0000329)5.17383452
4Rectal fistula (HP:0100590)4.84409615
5Rectovaginal fistula (HP:0000143)4.84409615
6Annular pancreas (HP:0001734)4.79909231
7Pustule (HP:0200039)4.44712330
8Increased IgM level (HP:0003496)4.44445720
9Hypochromic microcytic anemia (HP:0004840)4.40570369
10Intestinal fistula (HP:0100819)4.35753444
11Turricephaly (HP:0000262)4.35738716
12Vaginal fistula (HP:0004320)4.28631883
13Poikiloderma (HP:0001029)4.26311528
14Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.25724754
15Alopecia of scalp (HP:0002293)4.24121555
16Ulnar bowing (HP:0003031)4.12900488
17Tongue fasciculations (HP:0001308)4.08196445
18Chronic mucocutaneous candidiasis (HP:0002728)4.07251852
19Recurrent cutaneous fungal infections (HP:0011370)4.07251852
20Short humerus (HP:0005792)3.90743124
21Aplasia/hypoplasia of the humerus (HP:0006507)3.86934923
22Orthostatic hypotension (HP:0001278)3.78014649
23Muscle fibrillation (HP:0010546)3.77484404
24Coronal craniosynostosis (HP:0004440)3.70392364
25Stomatitis (HP:0010280)3.65122703
26Absent radius (HP:0003974)3.62306633
27Male infertility (HP:0003251)3.60364547
28Anteriorly placed anus (HP:0001545)3.44027647
29Absent forearm bone (HP:0003953)3.41721456
30Aplasia involving forearm bones (HP:0009822)3.41721456
31Intestinal atresia (HP:0011100)3.40454166
32Abnormal hemoglobin (HP:0011902)3.40171324
33Lipid accumulation in hepatocytes (HP:0006561)3.38935609
34Abnormal delayed hypersensitivity skin test (HP:0002963)3.36839619
35Vertebral hypoplasia (HP:0008417)3.32201699
36Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.32201699
37Dysautonomia (HP:0002459)3.29098159
38Increased hepatocellular lipid droplets (HP:0006565)3.26198000
39Absent thumb (HP:0009777)3.19142681
40Patellar aplasia (HP:0006443)3.18984288
41Squamous cell carcinoma (HP:0002860)3.14796131
42Pancreatic cysts (HP:0001737)3.14340358
43Abnormality of the aortic arch (HP:0012303)3.12652240
44Alacrima (HP:0000522)3.12017303
45Abnormality of male internal genitalia (HP:0000022)3.11976245
46Broad alveolar ridges (HP:0000187)3.09404386
47Congenital hip dislocation (HP:0001374)3.02266652
48Basal cell carcinoma (HP:0002671)3.00297782
49Short chin (HP:0000331)2.96260878
50Albinism (HP:0001022)2.95028408
51Aplasia/Hypoplasia of the patella (HP:0006498)2.89552055
52Abnormality of the renal cortex (HP:0011035)2.89543927
53Selective tooth agenesis (HP:0001592)2.85043934
54Fair hair (HP:0002286)2.84337413
55Abnormality of the labia minora (HP:0012880)2.84134553
56Urinary glycosaminoglycan excretion (HP:0003541)2.80259444
57Mucopolysacchariduria (HP:0008155)2.80259444
58Recurrent fungal infections (HP:0002841)2.78314984
59Premature skin wrinkling (HP:0100678)2.70652166
60Capillary hemangiomas (HP:0005306)2.70641478
61Pancreatic islet-cell hyperplasia (HP:0004510)2.69762594
62Premature graying of hair (HP:0002216)2.68278195
63Abnormality of T cell physiology (HP:0011840)2.62909218
64Elevated erythrocyte sedimentation rate (HP:0003565)2.59805839
65Thyroiditis (HP:0100646)2.59763578
66Volvulus (HP:0002580)2.57890426
67Severe combined immunodeficiency (HP:0004430)2.57058446
68Hypothermia (HP:0002045)2.56808163
69Aplasia/Hypoplasia of the fovea (HP:0008060)2.55933927
70Hypoplasia of the fovea (HP:0007750)2.55933927
71Abnormality of mucopolysaccharide metabolism (HP:0011020)2.54814122
72Abnormality of polysaccharide metabolism (HP:0011012)2.54814122
73Abnormality of glycosaminoglycan metabolism (HP:0004371)2.54814122
74Hemoptysis (HP:0002105)2.53834519
75Large for gestational age (HP:0001520)2.52267609
76Astrocytoma (HP:0009592)2.51168558
77Abnormality of the astrocytes (HP:0100707)2.51168558
78Hypotrichosis (HP:0001006)2.50737851
793-Methylglutaconic aciduria (HP:0003535)2.49043903
80Joint stiffness (HP:0001387)2.47415352
81Hypochromic anemia (HP:0001931)2.46575357
82Cheilitis (HP:0100825)2.46246659
83Hamartoma (HP:0010566)2.46033696
84Autoimmune hemolytic anemia (HP:0001890)2.45671456
85Aplasia of the musculature (HP:0100854)2.43445210
86Abnormality of T cells (HP:0002843)2.41871175
87Diaphragmatic weakness (HP:0009113)2.41664785
88Keratoconjunctivitis (HP:0001096)2.41649496
89Choanal stenosis (HP:0000452)2.41488144
90Hypotelorism (HP:0000601)2.41410245
91Dysostosis multiplex (HP:0000943)2.40819637
92Progressive inability to walk (HP:0002505)2.40657730
93Vertebral fusion (HP:0002948)2.40496902
94Attenuation of retinal blood vessels (HP:0007843)2.39333134
95Pancreatic fibrosis (HP:0100732)2.38345989
96Renal Fanconi syndrome (HP:0001994)2.37862368
97Periodontitis (HP:0000704)2.36830826
98Generalized hypopigmentation of hair (HP:0011358)2.35416361
99IgG deficiency (HP:0004315)2.35292788
100Decreased lacrimation (HP:0000633)2.33160815
101Tubular atrophy (HP:0000092)2.33144187
102Cerebral aneurysm (HP:0004944)2.33041934
103Abnormality of eosinophils (HP:0001879)2.32457246
104Molar tooth sign on MRI (HP:0002419)2.32303236
105Abnormality of midbrain morphology (HP:0002418)2.32303236
106Keratoconjunctivitis sicca (HP:0001097)2.31353675
107Panhypogammaglobulinemia (HP:0003139)2.31078652
108Growth hormone excess (HP:0000845)2.30370552
109Clumsiness (HP:0002312)2.29351382
110Methylmalonic acidemia (HP:0002912)2.28166626
111Acute lymphatic leukemia (HP:0006721)2.26399358
112Retrobulbar optic neuritis (HP:0100654)2.23814837
113Optic neuritis (HP:0100653)2.23814837
114Hypokinesia (HP:0002375)2.23307087
115Medial flaring of the eyebrow (HP:0010747)2.22848404
116Bowed forearm bones (HP:0003956)2.22607594
117Bowing of the arm (HP:0006488)2.22607594
118Autoimmune thrombocytopenia (HP:0001973)2.20204702
119Congenital stationary night blindness (HP:0007642)2.17988459
120Abnormality of chromosome stability (HP:0003220)2.16953581
121Neoplasm of the oral cavity (HP:0100649)2.16434643
122Increased number of teeth (HP:0011069)2.14456079
123Stomach cancer (HP:0012126)2.14357090
124Limb hypertonia (HP:0002509)2.14326219
125Hypoplasia of the radius (HP:0002984)2.13521210
126Toxemia of pregnancy (HP:0100603)2.13114239
127Popliteal pterygium (HP:0009756)2.12156633
128Polycythemia (HP:0001901)2.11462393
129Renal cortical cysts (HP:0000803)2.11035805
130Long clavicles (HP:0000890)2.10828452
131Abnormality of the prostate (HP:0008775)2.10731643
132Abnormality of T cell number (HP:0011839)2.10428766
133Leukocytosis (HP:0001974)2.10179372
134Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.09336146
135Abnormality of the pons (HP:0007361)2.08313851
136Split hand (HP:0001171)2.08246130
137IgA deficiency (HP:0002720)2.08125100
138Abnormality of the ileum (HP:0001549)2.05499915
139Gastrointestinal atresia (HP:0002589)2.05406349
140Muscle fiber atrophy (HP:0100295)2.04716709
141Asymmetric septal hypertrophy (HP:0001670)2.03628018
142Aplasia/Hypoplasia of the uvula (HP:0010293)2.03259220
143Combined immunodeficiency (HP:0005387)2.03160277
144Abolished electroretinogram (ERG) (HP:0000550)2.02467214
145Neutropenia (HP:0001875)2.02119665
146Narrow nasal bridge (HP:0000446)2.01883664
147Pendular nystagmus (HP:0012043)2.01249451
148Myositis (HP:0100614)1.99984942
149Ependymoma (HP:0002888)1.99740228
150Short 5th finger (HP:0009237)1.99700247
151Abnormality of the fovea (HP:0000493)1.99570999
152Nephronophthisis (HP:0000090)1.99296403
153Abnormality of the pancreatic islet cells (HP:0006476)1.98910639
154Abnormality of endocrine pancreas physiology (HP:0012093)1.98910639
155Encephalitis (HP:0002383)1.98625775
156Recurrent skin infections (HP:0001581)1.96717032
157Abnormality of B cell number (HP:0010975)1.96218053
158Amelogenesis imperfecta (HP:0000705)1.95184029
159Eosinophilia (HP:0001880)1.93448373
160Abnormal number of incisors (HP:0011064)1.93076174
161Abnormality of the renal medulla (HP:0100957)1.92355558
162Constricted visual fields (HP:0001133)1.92037646
163Azoospermia (HP:0000027)1.91913271
164Type 2 muscle fiber atrophy (HP:0003554)1.91216817
165Orchitis (HP:0100796)1.90484879
166Aplasia/Hypoplasia involving the musculature (HP:0001460)1.89969334
167Chronic hepatic failure (HP:0100626)1.89866422
168Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.88042099
169Breast hypoplasia (HP:0003187)1.87340308
170Lower limb hyperreflexia (HP:0002395)1.87186301
171Spinal muscular atrophy (HP:0007269)1.86816751
172Chronic diarrhea (HP:0002028)1.86678635
173Exertional dyspnea (HP:0002875)1.86622616
174Bilateral sensorineural hearing impairment (HP:0008619)1.86274077
175True hermaphroditism (HP:0010459)1.84981067
176Increased intramyocellular lipid droplets (HP:0012240)1.84783604
177Abnormal spermatogenesis (HP:0008669)1.84657134
178Ketosis (HP:0001946)1.82278033
179Vasculitis (HP:0002633)1.79906171
180Loss of speech (HP:0002371)1.78030020
181Prostate neoplasm (HP:0100787)1.76715413
182Pulmonary infiltrates (HP:0002113)1.76424498
183Clubbing of toes (HP:0100760)1.76392470
184Hypoplasia of the pons (HP:0012110)1.75233124
185Abnormality of the preputium (HP:0100587)1.73689758
186Meckel diverticulum (HP:0002245)1.73592210
187Generalized aminoaciduria (HP:0002909)1.71901919
188Ketoacidosis (HP:0001993)1.71704103
189Premature loss of primary teeth (HP:0006323)1.70903476
190T lymphocytopenia (HP:0005403)1.68815307
191Granulocytopenia (HP:0001913)1.66969797
192Aplasia/Hypoplasia of the spleen (HP:0010451)1.66523597

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.91136866
2DDR25.01440305
3MAP3K64.61455653
4MAPK154.52400552
5FRK4.32766249
6TXK4.27757968
7MAP3K113.45001490
8ACVR1B3.26603414
9PINK13.17826871
10TYRO33.04094238
11FGR2.91401166
12TAOK32.88225532
13MATK2.86927902
14NUAK12.65350665
15EIF2AK32.63405105
16DAPK12.49300232
17UHMK12.38016618
18PRKD22.17236557
19BMX2.16207752
20BMPR1B2.12750708
21PIM22.04651790
22YES12.03720024
23PDGFRA2.03179151
24CSK2.02216860
25DYRK1B1.93802530
26CDK71.93586594
27MST41.82855116
28ZAK1.74750817
29OBSCN1.71853256
30MAP4K11.71851057
31ADRBK21.66111357
32LATS21.65975792
33WNK41.63809054
34EPHA31.62843989
35IKBKB1.60197031
36TRPM71.53655833
37AKT31.51948309
38MAP3K141.44525461
39CCNB11.42576195
40PIM11.40242974
41CDK61.36683045
42VRK11.35428822
43OXSR11.34004466
44CHEK21.33614380
45CLK11.31435529
46MAP4K21.23873576
47GRK11.20644232
48PLK11.20403926
49TNK21.20256486
50PHKG21.19975754
51PHKG11.19975754
52CHUK1.18516133
53CDK191.16957633
54MUSK1.16501989
55RPS6KL11.16192797
56RPS6KC11.16192797
57CDC42BPA1.11363428
58STK391.10521940
59JAK31.07644172
60IKBKE1.03954613
61MAPK111.03804482
62CDK121.00332119
63RPS6KA61.00181037
64GSK3A0.99331227
65SYK0.98823787
66TEC0.97869927
67TYK20.97387130
68IRAK40.96678108
69DYRK30.94380943
70TAOK20.91869440
71CSF1R0.91539998
72WEE10.91170564
73PRPF4B0.90432401
74IRAK10.89064573
75CDC70.87886470
76NEK10.86912476
77WNK30.85075063
78MAP3K130.83800793
79LCK0.83168481
80MAP3K100.82897509
81ITK0.82463302
82NLK0.81602939
83BCR0.79154990
84TNIK0.77127655
85PRKAA10.76643426
86ATR0.75821406
87NEK20.75307007
88EIF2AK20.75142816
89JAK10.74391866
90MTOR0.73902698
91STK240.73728888
92PLK30.73147853
93RPS6KB20.70867755
94EPHA20.70409034
95TGFBR10.68941384
96PAK30.68841327
97EIF2AK10.65673122
98NEK60.65238262
99WNK10.65035418
100RPS6KA10.64821332
101PIK3CA0.64136594
102BUB10.64035229
103SGK20.63418482
104MAP3K40.63380895
105MAP2K60.63067659
106PRKCQ0.61143592
107RAF10.60912165
108CDK20.58797108
109KIT0.58223885
110DAPK20.58059582
111HCK0.57844568
112FES0.57294739
113HIPK20.56969689
114TRIM280.56482979
115AURKA0.55877586
116BLK0.55210896
117PIK3CG0.54749333
118MKNK20.54347564
119NME10.51901690
120DYRK20.51246517
121CSNK2A10.49825858
122ERBB30.49415218
123ZAP700.48184028
124BTK0.48088377
125MAPK130.47531000
126RPS6KB10.47164248
127JAK20.46918194
128TESK20.46577813
129TTK0.46494900
130CHEK10.44994489
131CAMKK20.44649004
132MAP2K30.44630472
133PRKCE0.44589533
134STK38L0.44124746
135EGFR0.43422060
136BRSK20.43362679
137AURKB0.43332603
138MARK30.40421114
139ADRBK10.39391295
140ATM0.37081885
141CSNK1A1L0.37011787
142PTK2B0.36800035
143PKN10.36683289
144LYN0.35779191
145MAP3K70.35759597
146MKNK10.35562581
147MAPK10.35456048
148STK30.34663154
149CSNK2A20.34510307
150CDK10.34175649
151MAPK100.32826338
152MAPK30.32729612
153STK100.32204854
154TRIB30.31938283
155MAPK140.31362976
156PDGFRB0.31160217
157MAPKAPK30.31067742
158LATS10.31045377
159CDK40.30666115
160CSNK1G10.29707197
161MELK0.27877591
162PRKAA20.27507195
163MAP3K90.27373084
164FLT30.27200304
165BRSK10.26587334
166CAMK2B0.26517351
167MAPK40.26494217
168BCKDK0.25587137
169CAMK2G0.25292732
170FGFR10.24853669
171INSR0.23396704
172CDK80.23337076
173PAK10.22158470
174MAPKAPK20.22073928
175CDK11A0.21658011
176CDK150.20453515
177TLK10.20186382
178CDK180.18898741
179PRKCI0.15976242

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002325.60687354
2Mismatch repair_Homo sapiens_hsa034305.47319642
3Base excision repair_Homo sapiens_hsa034104.87351066
4Fatty acid biosynthesis_Homo sapiens_hsa000614.81525781
5DNA replication_Homo sapiens_hsa030304.42330694
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053214.05858852
7Nucleotide excision repair_Homo sapiens_hsa034202.65415414
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.49391223
9Spliceosome_Homo sapiens_hsa030402.36774678
10RNA transport_Homo sapiens_hsa030132.31304523
11Homologous recombination_Homo sapiens_hsa034402.24766218
12Fanconi anemia pathway_Homo sapiens_hsa034602.07714618
13mRNA surveillance pathway_Homo sapiens_hsa030152.05000271
14Phototransduction_Homo sapiens_hsa047442.02881666
15mTOR signaling pathway_Homo sapiens_hsa041501.92909218
16Cell cycle_Homo sapiens_hsa041101.89538762
17Allograft rejection_Homo sapiens_hsa053301.89468869
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.88819227
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.87615005
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.85906916
21Autoimmune thyroid disease_Homo sapiens_hsa053201.85252974
22Graft-versus-host disease_Homo sapiens_hsa053321.82556202
23Circadian rhythm_Homo sapiens_hsa047101.82385389
24Hippo signaling pathway_Homo sapiens_hsa043901.82002491
25Protein export_Homo sapiens_hsa030601.77539795
26p53 signaling pathway_Homo sapiens_hsa041151.76480917
27Notch signaling pathway_Homo sapiens_hsa043301.75400717
28Hedgehog signaling pathway_Homo sapiens_hsa043401.74287126
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.73566224
30Arginine and proline metabolism_Homo sapiens_hsa003301.72886241
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.72014665
32Biosynthesis of amino acids_Homo sapiens_hsa012301.71377792
33Type I diabetes mellitus_Homo sapiens_hsa049401.71376042
34SNARE interactions in vesicular transport_Homo sapiens_hsa041301.70128657
35Measles_Homo sapiens_hsa051621.68669077
36NF-kappa B signaling pathway_Homo sapiens_hsa040641.65403450
37Nitrogen metabolism_Homo sapiens_hsa009101.63543385
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.61081390
39Rheumatoid arthritis_Homo sapiens_hsa053231.56600754
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.53489509
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.53184856
42Adherens junction_Homo sapiens_hsa045201.53026082
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.47329238
44Propanoate metabolism_Homo sapiens_hsa006401.44055780
45TGF-beta signaling pathway_Homo sapiens_hsa043501.34725018
46Jak-STAT signaling pathway_Homo sapiens_hsa046301.27821217
47Folate biosynthesis_Homo sapiens_hsa007901.27553170
48Sulfur relay system_Homo sapiens_hsa041221.27312836
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24713652
50Fatty acid metabolism_Homo sapiens_hsa012121.24249819
51Asthma_Homo sapiens_hsa053101.23701325
52One carbon pool by folate_Homo sapiens_hsa006701.20244686
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.19900751
54Longevity regulating pathway - mammal_Homo sapiens_hsa042111.16701032
55Fructose and mannose metabolism_Homo sapiens_hsa000511.13805734
56Leishmaniasis_Homo sapiens_hsa051401.13639606
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.10122770
58Basal cell carcinoma_Homo sapiens_hsa052171.09744392
59Bladder cancer_Homo sapiens_hsa052191.07585979
60Transcriptional misregulation in cancer_Homo sapiens_hsa052021.07454700
61Oocyte meiosis_Homo sapiens_hsa041141.07274139
62T cell receptor signaling pathway_Homo sapiens_hsa046601.02694602
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.02004063
64Shigellosis_Homo sapiens_hsa051310.99967602
65Linoleic acid metabolism_Homo sapiens_hsa005910.99958153
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.99950448
67Lysine degradation_Homo sapiens_hsa003100.99669623
68Wnt signaling pathway_Homo sapiens_hsa043100.99443081
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.99326732
70Antigen processing and presentation_Homo sapiens_hsa046120.96717996
71Toll-like receptor signaling pathway_Homo sapiens_hsa046200.91303712
72Colorectal cancer_Homo sapiens_hsa052100.90732492
73Regulation of autophagy_Homo sapiens_hsa041400.88744130
74Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.88711684
75Osteoclast differentiation_Homo sapiens_hsa043800.88395734
76Proteasome_Homo sapiens_hsa030500.87212407
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82993473
78Ether lipid metabolism_Homo sapiens_hsa005650.82219389
79Ribosome_Homo sapiens_hsa030100.82199671
80RNA polymerase_Homo sapiens_hsa030200.81447940
81RNA degradation_Homo sapiens_hsa030180.80901333
82MicroRNAs in cancer_Homo sapiens_hsa052060.78929244
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.78906657
84Tryptophan metabolism_Homo sapiens_hsa003800.78485464
85Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.77205781
86Hematopoietic cell lineage_Homo sapiens_hsa046400.76133291
87Butanoate metabolism_Homo sapiens_hsa006500.74665789
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.74148513
89Tuberculosis_Homo sapiens_hsa051520.71594378
90Purine metabolism_Homo sapiens_hsa002300.70968848
91Peroxisome_Homo sapiens_hsa041460.69903653
92VEGF signaling pathway_Homo sapiens_hsa043700.69588548
93Primary immunodeficiency_Homo sapiens_hsa053400.66963614
94Arginine biosynthesis_Homo sapiens_hsa002200.66774641
95Influenza A_Homo sapiens_hsa051640.65873787
96Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65538915
97Glycosaminoglycan degradation_Homo sapiens_hsa005310.64492934
98Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63875757
99Pyrimidine metabolism_Homo sapiens_hsa002400.63253621
100Viral carcinogenesis_Homo sapiens_hsa052030.63017399
101TNF signaling pathway_Homo sapiens_hsa046680.62835082
102Galactose metabolism_Homo sapiens_hsa000520.61983886
103Collecting duct acid secretion_Homo sapiens_hsa049660.61204167
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60521186
105Oxidative phosphorylation_Homo sapiens_hsa001900.60047466
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59485975
107Tight junction_Homo sapiens_hsa045300.57007519
108AMPK signaling pathway_Homo sapiens_hsa041520.56726373
109Viral myocarditis_Homo sapiens_hsa054160.55881154
110Basal transcription factors_Homo sapiens_hsa030220.55640685
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54698165
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52724916
113Thyroid cancer_Homo sapiens_hsa052160.51453943
114Parkinsons disease_Homo sapiens_hsa050120.50843723
115Chemical carcinogenesis_Homo sapiens_hsa052040.49457112
116Small cell lung cancer_Homo sapiens_hsa052220.48085645
117B cell receptor signaling pathway_Homo sapiens_hsa046620.47927922
118Epstein-Barr virus infection_Homo sapiens_hsa051690.46877886
119Primary bile acid biosynthesis_Homo sapiens_hsa001200.46031258
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46023504
121Olfactory transduction_Homo sapiens_hsa047400.44805672
122Chronic myeloid leukemia_Homo sapiens_hsa052200.44652306
123Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44607727
124Ovarian steroidogenesis_Homo sapiens_hsa049130.44224498
125Glutathione metabolism_Homo sapiens_hsa004800.43969466
126Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43934321
127Choline metabolism in cancer_Homo sapiens_hsa052310.43574999
128Legionellosis_Homo sapiens_hsa051340.42547690
129Staphylococcus aureus infection_Homo sapiens_hsa051500.42465671
130Selenocompound metabolism_Homo sapiens_hsa004500.42300006
131Gap junction_Homo sapiens_hsa045400.41575369
132Arachidonic acid metabolism_Homo sapiens_hsa005900.41558458
133Insulin signaling pathway_Homo sapiens_hsa049100.41405328
134Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41274011
135FoxO signaling pathway_Homo sapiens_hsa040680.38738725
136Pertussis_Homo sapiens_hsa051330.37456663
137Acute myeloid leukemia_Homo sapiens_hsa052210.35603983
138HTLV-I infection_Homo sapiens_hsa051660.35374061
139Central carbon metabolism in cancer_Homo sapiens_hsa052300.34288203
140African trypanosomiasis_Homo sapiens_hsa051430.33093224
141Cysteine and methionine metabolism_Homo sapiens_hsa002700.33007160
142Herpes simplex infection_Homo sapiens_hsa051680.32653152
143Toxoplasmosis_Homo sapiens_hsa051450.31904665
144ErbB signaling pathway_Homo sapiens_hsa040120.30443485
145Hepatitis C_Homo sapiens_hsa051600.29968959
146Dorso-ventral axis formation_Homo sapiens_hsa043200.29592777
147Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.27601772
148Endometrial cancer_Homo sapiens_hsa052130.27066129
149Chemokine signaling pathway_Homo sapiens_hsa040620.27001323
150Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.24964530
151Non-homologous end-joining_Homo sapiens_hsa034500.23931066
152Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.23894366
153Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.23780633
154Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.22970716
155PI3K-Akt signaling pathway_Homo sapiens_hsa041510.22221072
156Proteoglycans in cancer_Homo sapiens_hsa052050.22190745
157Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.19138158
158Pathways in cancer_Homo sapiens_hsa052000.18251449
159Carbon metabolism_Homo sapiens_hsa012000.17534708
160Hepatitis B_Homo sapiens_hsa051610.17391310
161Fatty acid elongation_Homo sapiens_hsa000620.16918235
162Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.16385115
163Prostate cancer_Homo sapiens_hsa052150.13180598
164Thyroid hormone signaling pathway_Homo sapiens_hsa049190.13084963
165Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.12513229
166Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.11474577

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