DDX60L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the DExD/H-box helicase family of proteins, a subset of the super family 2 helicases. Members of the DExD/H-box helicase family share a conserved functional core comprised of two RecA-like globular domains. These domains contain conserved motifs that mediate ATP binding, ATP hydrolysis, nucleic acid binding, and RNA unwinding. In addition to functions in RNA metabolism, members of this family are involved in anti-viral immunity and act as cytosolic sensors of viral nucleic acids. The protein encoded by this gene has been shown to inhibit hepatitis C virus replication in response to interferon stimulation in cell culture. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.59903518
2positive regulation by symbiont of host defense response (GO:0052509)5.40566176
3modulation by symbiont of host defense response (GO:0052031)5.40566176
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.40566176
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.40566176
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.40566176
7modulation by symbiont of host immune response (GO:0052553)5.40566176
8detection of molecule of bacterial origin (GO:0032490)5.11116591
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.06320419
10negative regulation of cell killing (GO:0031342)5.06320419
11macrophage activation involved in immune response (GO:0002281)4.91767051
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.82606384
13negative regulation of interleukin-12 production (GO:0032695)4.74843078
14positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.70190514
15cellular response to type I interferon (GO:0071357)4.70113197
16type I interferon signaling pathway (GO:0060337)4.70113197
17response to type I interferon (GO:0034340)4.67687519
18response to peptidoglycan (GO:0032494)4.60239616
19microglial cell activation (GO:0001774)4.34201725
20regulation of B cell receptor signaling pathway (GO:0050855)4.27249074
21antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.24715297
22regulation of interferon-beta biosynthetic process (GO:0045357)4.24465987
23neutrophil activation involved in immune response (GO:0002283)4.20197852
24detection of other organism (GO:0098543)4.18471797
25detection of external biotic stimulus (GO:0098581)4.15199051
26regulation of interferon-alpha production (GO:0032647)4.05030116
27regulation of gamma-delta T cell activation (GO:0046643)4.03557229
28positive regulation of interferon-alpha production (GO:0032727)4.03115565
29antigen processing and presentation of endogenous antigen (GO:0019883)4.03098079
30response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.99070703
31response to host immune response (GO:0052572)3.99070703
32antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.93154802
33macrophage activation (GO:0042116)3.84721669
34cellular extravasation (GO:0045123)3.83817081
35positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.83066314
36negative regulation of T cell mediated immunity (GO:0002710)3.73469833
37response to interferon-alpha (GO:0035455)3.69765574
38detection of bacterium (GO:0016045)3.69208735
39response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.67335851
40response to host (GO:0075136)3.67335851
41response to host defenses (GO:0052200)3.67335851
42detection of biotic stimulus (GO:0009595)3.64620261
43interferon-gamma-mediated signaling pathway (GO:0060333)3.60192468
44negative regulation of lymphocyte mediated immunity (GO:0002707)3.58992783
45immunoglobulin mediated immune response (GO:0016064)3.58289766
46lipopolysaccharide-mediated signaling pathway (GO:0031663)3.49835426
47neutrophil mediated immunity (GO:0002446)3.49184704
48regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.47636541
49positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.42961177
50myeloid cell activation involved in immune response (GO:0002275)3.40149431
51neutrophil activation (GO:0042119)3.39205499
52regulation of gamma-delta T cell differentiation (GO:0045586)3.37905373
53leukocyte aggregation (GO:0070486)3.35047717
54positive regulation of interferon-beta production (GO:0032728)3.32253698
55positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.30803265
56regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.27414705
57granulocyte activation (GO:0036230)3.25237239
58defense response to protozoan (GO:0042832)3.25129908
59positive regulation of toll-like receptor signaling pathway (GO:0034123)3.24482043
60T cell migration (GO:0072678)3.21303357
61regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.20570782
62production of molecular mediator involved in inflammatory response (GO:0002532)3.16614435
63myeloid leukocyte mediated immunity (GO:0002444)3.16432518
64negative regulation of viral genome replication (GO:0045071)3.16261037
65negative regulation of leukocyte mediated immunity (GO:0002704)3.10899238
66cellular response to interferon-alpha (GO:0035457)3.09057887
67germinal center formation (GO:0002467)3.08368948
68response to muramyl dipeptide (GO:0032495)3.05605281
69response to interleukin-15 (GO:0070672)3.05250676
70respiratory burst (GO:0045730)3.03974432
71positive regulation of type 2 immune response (GO:0002830)3.03409432
72regulation of tolerance induction (GO:0002643)3.02148046
73T-helper 1 type immune response (GO:0042088)2.99878494
74response to protozoan (GO:0001562)2.96935522
75regulation of T cell tolerance induction (GO:0002664)2.95474425
76B cell receptor signaling pathway (GO:0050853)2.91911131
77regulation of dendritic cell antigen processing and presentation (GO:0002604)2.89543771
78negative regulation of cytokine production involved in immune response (GO:0002719)2.85864398
79regulation of regulatory T cell differentiation (GO:0045589)2.84715076
80regulation of interferon-beta production (GO:0032648)2.83062604
81regulation of interleukin-12 biosynthetic process (GO:0045075)2.81835758
82antigen processing and presentation via MHC class Ib (GO:0002475)2.80934287
83regulation of T-helper 2 cell differentiation (GO:0045628)2.80895899
84positive regulation of interleukin-1 beta secretion (GO:0050718)2.79361401
85B cell mediated immunity (GO:0019724)2.79173202
86negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.78787859
87negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.78653509
88response to interferon-beta (GO:0035456)2.77222506
89regulation of type 2 immune response (GO:0002828)2.75825085
90cellular response to interleukin-15 (GO:0071350)2.75817932
91myeloid leukocyte activation (GO:0002274)2.75569188
92dendritic cell migration (GO:0036336)2.73834212
93defense response to virus (GO:0051607)2.73308379
94regulation of mast cell activation (GO:0033003)2.73155445
95negative regulation of T-helper cell differentiation (GO:0045623)2.73054198
96negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.73054198
97regulation of toll-like receptor signaling pathway (GO:0034121)2.71215213
98positive regulation of tolerance induction (GO:0002645)2.71124324
99regulation of necroptotic process (GO:0060544)2.70232499
100regulation of mast cell degranulation (GO:0043304)2.70032338

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.11519268
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.83365443
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.79914766
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.39324413
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.11379548
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.67392321
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.57551200
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.41505865
9SMAD_19615063_ChIP-ChIP_OVARY_Human3.40524193
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.27167384
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.22989122
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.11232882
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.88364869
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.83977437
15RUNX_20019798_ChIP-Seq_JUKART_Human2.66944195
16Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.57657334
17RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.31492214
18GATA1_22025678_ChIP-Seq_K562_Human2.23975856
19MYB_26560356_Chip-Seq_TH2_Human2.22115392
20SCL_19346495_ChIP-Seq_HPC-7_Human2.18469078
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.18306338
22VDR_24787735_ChIP-Seq_THP-1_Human2.14732934
23FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.13753344
24* SPI1_23547873_ChIP-Seq_NB4_Human2.13590406
25SPI1_23127762_ChIP-Seq_K562_Human2.12313300
26EGR1_19374776_ChIP-ChIP_THP-1_Human1.94100264
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.91928155
28VDR_24763502_ChIP-Seq_THP-1_Human1.86987770
29BRD4_27068464_Chip-Seq_AML-cells_Mouse1.78507123
30MYB_26560356_Chip-Seq_TH1_Human1.74705215
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.73336952
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.66164864
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.65046767
34GATA3_27048872_Chip-Seq_THYMUS_Human1.63608573
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.63124795
36BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.60932845
37MAF_26560356_Chip-Seq_TH1_Human1.60402059
38PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.56373522
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.53486290
40GATA3_26560356_Chip-Seq_TH2_Human1.52419336
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.52206674
42GATA2_21666600_ChIP-Seq_HMVEC_Human1.49621448
43PU_27001747_Chip-Seq_BMDM_Mouse1.45107771
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.37407690
45PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.34327051
46STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.30034230
47NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.29576535
48GATA1_19941827_ChIP-Seq_MEL_Mouse1.27381726
49STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.25171010
50CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24442535
51VDR_21846776_ChIP-Seq_THP-1_Human1.23634622
52UTX_26944678_Chip-Seq_JUKART_Human1.22311210
53LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.20838273
54MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.18647394
55LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.18402021
56GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16264261
57TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09851913
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09066957
59SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07057737
60TCF7_22412390_ChIP-Seq_EML_Mouse1.04830174
61GATA1_19941826_ChIP-Seq_K562_Human1.02429596
62KDM2B_26808549_Chip-Seq_SUP-B15_Human0.96501432
63GATA2_19941826_ChIP-Seq_K562_Human0.96195504
64CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95246784
65RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.95139701
66MAF_26560356_Chip-Seq_TH2_Human0.93677705
67CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92361686
68VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.91890785
69GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89472264
70SMRT_27268052_Chip-Seq_Bcells_Human0.88763145
71CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85487319
72PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84914984
73BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83664982
74GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82525318
75KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.81902067
76GATA1_19941827_ChIP-Seq_MEL86_Mouse0.81495033
77CDX2_19796622_ChIP-Seq_MESCs_Mouse0.81425558
78KDM2B_26808549_Chip-Seq_DND41_Human0.78020845
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.77711054
80SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.76732771
81* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76173527
82TP53_16413492_ChIP-PET_HCT116_Human0.74008454
83PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73939597
84* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73616720
85SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.73420804
86FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.73372174
87CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.73253842
88FOXO3_23340844_ChIP-Seq_DLD1_Human0.72769305
89FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.72766677
90TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72184030
91CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.69373685
92GATA1_22383799_ChIP-Seq_G1ME_Mouse0.68837521
93EGR1_23403033_ChIP-Seq_LIVER_Mouse0.66399297
94* TP63_23658742_ChIP-Seq_EP156T_Human0.65976801
95PRDM14_20953172_ChIP-Seq_ESCs_Human0.65192896
96KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.63928508
97LXR_22158963_ChIP-Seq_LIVER_Mouse0.63737081
98ESR1_20079471_ChIP-ChIP_T-47D_Human0.63524983
99CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.61793401
100KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.61167408

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.12824725
2MP0003303_peritoneal_inflammation4.12995473
3MP0001835_abnormal_antigen_presentation3.92964292
4MP0003436_decreased_susceptibility_to3.48891545
5MP0009785_altered_susceptibility_to3.26176965
6MP0006082_CNS_inflammation3.05646640
7MP0002419_abnormal_innate_immunity2.86902771
8MP0001800_abnormal_humoral_immune2.76188841
9MP0005000_abnormal_immune_tolerance2.73833302
10MP0005025_abnormal_response_to2.72130044
11MP0005671_abnormal_response_to2.71862104
12MP0001790_abnormal_immune_system2.62045782
13MP0005387_immune_system_phenotype2.62045782
14MP0002148_abnormal_hypersensitivity_rea2.61665656
15MP0002723_abnormal_immune_serum2.50168691
16MP0002452_abnormal_antigen_presenting2.45686442
17MP0000685_abnormal_immune_system2.45528802
18MP0003300_gastrointestinal_ulcer2.42286465
19MP0000569_abnormal_digit_pigmentation2.33977090
20MP0002420_abnormal_adaptive_immunity2.23895271
21MP0001819_abnormal_immune_cell2.23112657
22MP0008260_abnormal_autophagy2.13637198
23MP0001533_abnormal_skeleton_physiology2.04738911
24MP0003191_abnormal_cellular_cholesterol1.93833620
25MP0009764_decreased_sensitivity_to1.93013340
26MP0003763_abnormal_thymus_physiology1.90009508
27MP0003172_abnormal_lysosome_physiology1.87476307
28MP0002405_respiratory_system_inflammati1.85166379
29MP0005451_abnormal_body_composition1.82327234
30MP0004947_skin_inflammation1.81452294
31MP0001845_abnormal_inflammatory_respons1.77942534
32MP0010155_abnormal_intestine_physiology1.75152193
33MP0005464_abnormal_platelet_physiology1.71636747
34MP0000716_abnormal_immune_system1.70111306
35MP0002398_abnormal_bone_marrow1.62930327
36MP0004883_abnormal_blood_vessel1.55845890
37MP0003828_pulmonary_edema1.54608235
38MP0008469_abnormal_protein_level1.53504942
39MP0009278_abnormal_bone_marrow1.51457753
40MP0003656_abnormal_erythrocyte_physiolo1.46739790
41MP0001545_abnormal_hematopoietic_system1.44840113
42MP0005397_hematopoietic_system_phenotyp1.44840113
43MP0005164_abnormal_response_to1.44737509
44MP0005310_abnormal_salivary_gland1.44076811
45MP0003075_altered_response_to1.41681507
46MP0004510_myositis1.40118203
47MP0002166_altered_tumor_susceptibility1.39947198
48MP0000858_altered_metastatic_potential1.37179081
49MP0000689_abnormal_spleen_morphology1.36203773
50MP0002332_abnormal_exercise_endurance1.34526370
51MP0002722_abnormal_immune_system1.32573752
52MP0003183_abnormal_peptide_metabolism1.31138806
53MP0003690_abnormal_glial_cell1.30419451
54MP0002429_abnormal_blood_cell1.29488319
55MP0002998_abnormal_bone_remodeling1.28302828
56MP0005058_abnormal_lysosome_morphology1.26337637
57MP0000465_gastrointestinal_hemorrhage1.26087756
58MP0009333_abnormal_splenocyte_physiolog1.25223274
59MP0003448_altered_tumor_morphology1.22030357
60MP0000343_altered_response_to1.18620841
61MP0008004_abnormal_stomach_pH1.18578566
62MP0001853_heart_inflammation1.18357443
63MP0003866_abnormal_defecation1.15684606
64MP0004381_abnormal_hair_follicle1.13211330
65MP0006054_spinal_hemorrhage1.11179181
66MP0002006_tumorigenesis1.10875850
67MP0005166_decreased_susceptibility_to1.09902816
68MP0000604_amyloidosis1.08021217
69MP0000703_abnormal_thymus_morphology1.05270577
70MP0004808_abnormal_hematopoietic_stem1.05099256
71MP0001851_eye_inflammation1.01297071
72MP0002277_abnormal_respiratory_mucosa1.00879222
73MP0003045_fibrosis0.99823619
74MP0009763_increased_sensitivity_to0.99079117
75MP0003221_abnormal_cardiomyocyte_apopto0.94717208
76MP0002396_abnormal_hematopoietic_system0.93641351
77MP0002132_abnormal_respiratory_system0.93487559
78MP0003091_abnormal_cell_migration0.93056787
79MP0000015_abnormal_ear_pigmentation0.89243721
80MP0002138_abnormal_hepatobiliary_system0.85081535
81MP0003195_calcinosis0.83446718
82MP0001663_abnormal_digestive_system0.78045187
83MP0005390_skeleton_phenotype0.77988604
84MP0000249_abnormal_blood_vessel0.77783884
85MP0005167_abnormal_blood-brain_barrier0.77572373
86MP0009765_abnormal_xenobiotic_induced0.75784168
87MP0003453_abnormal_keratinocyte_physiol0.68685598
88MP0000371_diluted_coat_color0.68491641
89MP0004484_altered_response_of0.65511184
90MP0002933_joint_inflammation0.64819509
91MP0008874_decreased_physiological_sensi0.64583642
92MP0005376_homeostasis/metabolism_phenot0.63841416
93MP0005174_abnormal_tail_pigmentation0.63298156
94MP0009840_abnormal_foam_cell0.62752607
95MP0003787_abnormal_imprinting0.60503947
96MP0008057_abnormal_DNA_replication0.60033270
97MP0003795_abnormal_bone_structure0.59650168
98MP0003806_abnormal_nucleotide_metabolis0.59008727
99MP0004130_abnormal_muscle_cell0.57363298
100MP0002877_abnormal_melanocyte_morpholog0.55527657

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)5.90191812
2Retrobulbar optic neuritis (HP:0100654)5.81057456
3Optic neuritis (HP:0100653)5.81057456
4Orchitis (HP:0100796)5.73231553
5Eczematoid dermatitis (HP:0000976)5.68905331
6Myositis (HP:0100614)5.60584838
7Recurrent abscess formation (HP:0002722)5.52060931
8Abnormality of macrophages (HP:0004311)4.68272417
9Stomatitis (HP:0010280)4.47850740
10T lymphocytopenia (HP:0005403)4.26412832
11Elevated erythrocyte sedimentation rate (HP:0003565)4.25725851
12Recurrent gram-negative bacterial infections (HP:0005420)4.21930472
13Recurrent fungal infections (HP:0002841)4.21889346
14Keratoconjunctivitis sicca (HP:0001097)4.20825299
15Gastrointestinal infarctions (HP:0005244)4.16116407
16Abnormality of T cell number (HP:0011839)4.13248046
17Recurrent skin infections (HP:0001581)3.96481680
18Keratoconjunctivitis (HP:0001096)3.92537504
19Mediastinal lymphadenopathy (HP:0100721)3.86315933
20Chronic mucocutaneous candidiasis (HP:0002728)3.81505179
21Recurrent cutaneous fungal infections (HP:0011370)3.81505179
22Vasculitis (HP:0002633)3.65131984
23Gingivitis (HP:0000230)3.63287994
24Abnormal delayed hypersensitivity skin test (HP:0002963)3.52660765
25Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.44077561
26Hemoptysis (HP:0002105)3.36080701
27Encephalitis (HP:0002383)3.35660738
28Meningitis (HP:0001287)3.33772165
29Arterial thrombosis (HP:0004420)3.27030842
30Recurrent viral infections (HP:0004429)3.25801556
31Spontaneous hematomas (HP:0007420)3.25262844
32Peritonitis (HP:0002586)3.23451968
33Pulmonary infiltrates (HP:0002113)3.21800432
34Obstructive lung disease (HP:0006536)3.13520143
35Chronic obstructive pulmonary disease (HP:0006510)3.13520143
36Gingival bleeding (HP:0000225)3.10145013
37Leukocytosis (HP:0001974)3.00326340
38Urticaria (HP:0001025)2.87527165
39Abnormality of T cells (HP:0002843)2.81295987
40Autoimmune thrombocytopenia (HP:0001973)2.81133101
41Abnormality of glycolipid metabolism (HP:0010969)2.80353023
42Abnormality of liposaccharide metabolism (HP:0010968)2.80353023
43Abnormality of glycosphingolipid metabolism (HP:0004343)2.80353023
44Chest pain (HP:0100749)2.79871081
45Gangrene (HP:0100758)2.74612761
46Autoimmune hemolytic anemia (HP:0001890)2.73629133
47Anorexia (HP:0002039)2.71102235
48Pulmonary embolism (HP:0002204)2.65501028
49Amyloidosis (HP:0011034)2.58934478
50Loss of speech (HP:0002371)2.45920120
51Increased IgM level (HP:0003496)2.45589969
52Episodic fever (HP:0001954)2.44425658
53Eosinophilia (HP:0001880)2.43914528
54Increased IgE level (HP:0003212)2.43520600
55Epistaxis (HP:0000421)2.43387610
56Recurrent bronchitis (HP:0002837)2.41757483
57Prolonged bleeding time (HP:0003010)2.37359641
58Cellulitis (HP:0100658)2.37138098
59Abnormality of the pleura (HP:0002103)2.35976261
60Inflammation of the large intestine (HP:0002037)2.35424242
61Granulocytopenia (HP:0001913)2.35304794
62Pustule (HP:0200039)2.33728227
63Abnormality of the endocardium (HP:0004306)2.32854173
64Hematochezia (HP:0002573)2.29642168
65Increased cerebral lipofuscin (HP:0011813)2.28461737
66Keratitis (HP:0000491)2.25118486
67Abnormality of the peritoneum (HP:0002585)2.19540382
68Osteomyelitis (HP:0002754)2.17596635
69Hypergammaglobulinemia (HP:0010702)2.17302863
70Slow saccadic eye movements (HP:0000514)2.16220188
71Vertigo (HP:0002321)2.15607948
72Gastrointestinal inflammation (HP:0004386)2.15037719
73Glomerulopathy (HP:0100820)2.12058361
74Colitis (HP:0002583)2.11890919
75Interstitial pulmonary disease (HP:0006530)2.11541974
76Abnormality of eosinophils (HP:0001879)2.11025130
77Subacute progressive viral hepatitis (HP:0006572)2.09817047
78Disinhibition (HP:0000734)2.08969965
79Polyneuropathy (HP:0001271)2.08134268
80Cheilitis (HP:0100825)2.07512326
81Abnormality of the pericardium (HP:0001697)2.02985442
82Abnormality of T cell physiology (HP:0011840)2.01772878
83Acute hepatic failure (HP:0006554)2.00193542
84Dysostosis multiplex (HP:0000943)1.96775234
85Abnormality of the vasculature of the conjunctiva (HP:0008054)1.96610941
86Lymphopenia (HP:0001888)1.95936365
87Viral hepatitis (HP:0006562)1.94932790
88Acne (HP:0001061)1.93441538
89Sepsis (HP:0100806)1.93097495
90Periodontitis (HP:0000704)1.91635560
91Abnormality of cells of the lymphoid lineage (HP:0012140)1.90946345
92Chronic otitis media (HP:0000389)1.89442383
93Hypochromic microcytic anemia (HP:0004840)1.88647330
94Systemic lupus erythematosus (HP:0002725)1.87531217
95Hypochromic anemia (HP:0001931)1.87197886
96Increased neuronal autofluorescent lipopigment (HP:0002074)1.86652716
97Vacuolated lymphocytes (HP:0001922)1.86085487
98Neoplasm of the tracheobronchial system (HP:0100552)1.85725098
99Panhypogammaglobulinemia (HP:0003139)1.85441622
100Joint swelling (HP:0001386)1.85334168

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.89879920
2BLK3.55945256
3TYK23.32360125
4IRAK43.09070001
5MAP4K12.78062073
6IKBKE2.70244010
7CSK2.61382094
8JAK32.54148728
9MAP3K142.51202935
10MAP2K32.48783250
11TXK2.45078868
12JAK12.22541331
13FGR1.94235884
14ZAP701.90583008
15FES1.84047427
16TBK11.79592958
17BMPR21.74566060
18TAOK31.74191039
19SYK1.70446604
20GRK61.69729377
21BTK1.67772235
22IRAK11.57513092
23MATK1.57248803
24KIT1.54093287
25MAP3K31.50628559
26JAK21.49021927
27GRK71.46200904
28EPHB11.45692525
29HCK1.45492407
30IRAK31.45431216
31FGFR31.43851056
32PRPF4B1.40579353
33LYN1.37533536
34MAP3K131.34270045
35FRK1.32933418
36TEC1.32123582
37IKBKB1.30554831
38TGFBR21.25910266
39TAOK11.23770363
40ERN11.23270226
41FGFR41.21594301
42PIK3CG1.21080688
43LCK1.15160844
44MAP3K11.14421376
45ITK1.14287143
46IRAK21.12657108
47CSF1R1.11864124
48TNK21.08893186
49MAP3K21.05757934
50YES11.02239014
51ACVR1B1.00105722
52MARK30.98455451
53MAP3K60.92260454
54RIPK10.90763444
55MAP3K110.89094283
56STK100.88199903
57PTK2B0.86650276
58TAOK20.84248228
59CAMKK20.81588585
60KSR20.81018403
61CDC42BPA0.78203627
62MARK20.77566007
63MAP3K50.75021697
64NLK0.72580141
65SIK30.70779119
66PDK10.70662332
67EPHA30.69461298
68CHUK0.66134462
69PIM10.64646866
70WNK10.61004639
71MOS0.60914093
72MAP2K60.60216004
73SGK30.57291904
74HIPK20.56849690
75SGK20.55890706
76TRPM70.54932292
77LRRK20.51743799
78KSR10.51670270
79CDK190.51562513
80MAPK70.51152131
81FYN0.48723598
82PDPK10.48304628
83NEK90.47245771
84ADRBK20.45832447
85EGFR0.42839435
86PRKCQ0.42628852
87PDGFRB0.41027963
88CDK60.40893434
89STK380.38803226
90MAP3K70.38586402
91MAPK110.36679499
92STK240.35984161
93STK110.34650215
94ABL10.34542028
95RAF10.33217391
96DYRK1B0.32685145
97PRKD20.32151279
98GRK50.30721971
99DAPK20.30011734
100PTK60.29633608

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.02471455
2Osteoclast differentiation_Homo sapiens_hsa043802.82084776
3Toll-like receptor signaling pathway_Homo sapiens_hsa046202.55594429
4Staphylococcus aureus infection_Homo sapiens_hsa051502.54381032
5NOD-like receptor signaling pathway_Homo sapiens_hsa046212.35364878
6RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.26993296
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.18538691
8Allograft rejection_Homo sapiens_hsa053302.18380277
9Graft-versus-host disease_Homo sapiens_hsa053322.17982970
10Tuberculosis_Homo sapiens_hsa051522.14961001
11Measles_Homo sapiens_hsa051622.12081104
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.11550388
13Malaria_Homo sapiens_hsa051442.05212721
14Influenza A_Homo sapiens_hsa051641.94313139
15B cell receptor signaling pathway_Homo sapiens_hsa046621.94136151
16Autoimmune thyroid disease_Homo sapiens_hsa053201.93767771
17Legionellosis_Homo sapiens_hsa051341.88928414
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.87118423
19TNF signaling pathway_Homo sapiens_hsa046681.76292661
20Hematopoietic cell lineage_Homo sapiens_hsa046401.69734937
21Toxoplasmosis_Homo sapiens_hsa051451.66359522
22Primary immunodeficiency_Homo sapiens_hsa053401.61809048
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.58419871
24Type I diabetes mellitus_Homo sapiens_hsa049401.54714500
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.54455702
26Chemokine signaling pathway_Homo sapiens_hsa040621.52424105
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.51746500
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.51087976
29Asthma_Homo sapiens_hsa053101.50597392
30Herpes simplex infection_Homo sapiens_hsa051681.49615664
31Hepatitis C_Homo sapiens_hsa051601.47728805
32T cell receptor signaling pathway_Homo sapiens_hsa046601.46870200
33African trypanosomiasis_Homo sapiens_hsa051431.46635175
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.42018093
35Pertussis_Homo sapiens_hsa051331.41699651
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.41652281
37Rheumatoid arthritis_Homo sapiens_hsa053231.39303210
38Antigen processing and presentation_Homo sapiens_hsa046121.36415464
39Hepatitis B_Homo sapiens_hsa051611.33435257
40Acute myeloid leukemia_Homo sapiens_hsa052211.27143003
41Other glycan degradation_Homo sapiens_hsa005111.24510341
42Phagosome_Homo sapiens_hsa041451.19524110
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.16796849
44Viral myocarditis_Homo sapiens_hsa054161.12213674
45Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.07834656
46Salmonella infection_Homo sapiens_hsa051321.04677657
47Prolactin signaling pathway_Homo sapiens_hsa049171.04528229
48Platelet activation_Homo sapiens_hsa046110.99066197
49Lysosome_Homo sapiens_hsa041420.98811889
50Dorso-ventral axis formation_Homo sapiens_hsa043200.96985187
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.96080913
52Apoptosis_Homo sapiens_hsa042100.93042811
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.91233423
54Non-small cell lung cancer_Homo sapiens_hsa052230.90909584
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90195134
56Pancreatic cancer_Homo sapiens_hsa052120.87158925
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83026744
58Shigellosis_Homo sapiens_hsa051310.77611341
59Adipocytokine signaling pathway_Homo sapiens_hsa049200.77142964
60Chronic myeloid leukemia_Homo sapiens_hsa052200.74646515
61Amoebiasis_Homo sapiens_hsa051460.74371519
62VEGF signaling pathway_Homo sapiens_hsa043700.73922170
63Glycosaminoglycan degradation_Homo sapiens_hsa005310.71533483
64FoxO signaling pathway_Homo sapiens_hsa040680.70766889
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.67397684
66Renal cell carcinoma_Homo sapiens_hsa052110.64649624
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.62927395
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61759084
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60871651
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60582558
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56062751
72Epstein-Barr virus infection_Homo sapiens_hsa051690.54188982
73Notch signaling pathway_Homo sapiens_hsa043300.52338627
74Type II diabetes mellitus_Homo sapiens_hsa049300.52210247
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50725848
76Viral carcinogenesis_Homo sapiens_hsa052030.50264646
77Insulin resistance_Homo sapiens_hsa049310.49262116
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49239127
79Complement and coagulation cascades_Homo sapiens_hsa046100.48623972
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48463381
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.47627998
82HIF-1 signaling pathway_Homo sapiens_hsa040660.44723329
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43179453
84GnRH signaling pathway_Homo sapiens_hsa049120.43071255
85mTOR signaling pathway_Homo sapiens_hsa041500.42320943
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42199905
87Endocytosis_Homo sapiens_hsa041440.41420276
88Inositol phosphate metabolism_Homo sapiens_hsa005620.40924599
89HTLV-I infection_Homo sapiens_hsa051660.40788375
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40680137
91MAPK signaling pathway_Homo sapiens_hsa040100.38264558
92Endometrial cancer_Homo sapiens_hsa052130.36778504
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33332342
94Choline metabolism in cancer_Homo sapiens_hsa052310.32728068
95Bladder cancer_Homo sapiens_hsa052190.32716097
96ErbB signaling pathway_Homo sapiens_hsa040120.32051566
97Prostate cancer_Homo sapiens_hsa052150.31402176
98Small cell lung cancer_Homo sapiens_hsa052220.30369960
99Glioma_Homo sapiens_hsa052140.25860877
100Fatty acid biosynthesis_Homo sapiens_hsa000610.23593616

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