DDX6P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1signal peptide processing (GO:0006465)6.76365756
2positive regulation of immune response to tumor cell (GO:0002839)5.81835749
3regulation of immune response to tumor cell (GO:0002837)5.81835749
4regulation of response to tumor cell (GO:0002834)5.81835749
5positive regulation of response to tumor cell (GO:0002836)5.81835749
6activated T cell proliferation (GO:0050798)5.23794094
7DNA deamination (GO:0045006)4.60807648
8antigen processing and presentation via MHC class Ib (GO:0002475)4.55880709
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.41028289
10regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.37472860
11kidney morphogenesis (GO:0060993)4.29052164
12detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.20278826
13positive regulation of T cell chemotaxis (GO:0010820)4.14766807
14regulation of T cell chemotaxis (GO:0010819)4.14766807
15cell wall macromolecule catabolic process (GO:0016998)4.08584126
16adult feeding behavior (GO:0008343)4.02736590
17phasic smooth muscle contraction (GO:0014821)3.95000516
18detection of light stimulus involved in sensory perception (GO:0050962)3.94275196
19detection of light stimulus involved in visual perception (GO:0050908)3.94275196
20atrial cardiac muscle cell action potential (GO:0086014)3.90165055
21pseudouridine synthesis (GO:0001522)3.83600906
22positive regulation of tolerance induction (GO:0002645)3.81934208
23response to xenobiotic stimulus (GO:0009410)3.67771466
24negative regulation of reactive oxygen species metabolic process (GO:2000378)3.67336800
25respiratory chain complex IV assembly (GO:0008535)3.62645198
26peristalsis (GO:0030432)3.62387149
27presynaptic membrane assembly (GO:0097105)3.58461166
28response to pheromone (GO:0019236)3.58404480
29cytochrome complex assembly (GO:0017004)3.53304317
30lung lobe morphogenesis (GO:0060463)3.52168268
31regulation of T cell tolerance induction (GO:0002664)3.47979186
32L-fucose catabolic process (GO:0042355)3.40103113
33fucose catabolic process (GO:0019317)3.40103113
34L-fucose metabolic process (GO:0042354)3.40103113
35mitochondrial respiratory chain complex I assembly (GO:0032981)3.38928794
36NADH dehydrogenase complex assembly (GO:0010257)3.38928794
37mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.38928794
38postsynaptic membrane organization (GO:0001941)3.35277420
39retinal cone cell development (GO:0046549)3.34768139
40cell wall macromolecule metabolic process (GO:0044036)3.33713952
41peptidyl-histidine modification (GO:0018202)3.33535092
42cullin deneddylation (GO:0010388)3.26875285
43protein complex biogenesis (GO:0070271)3.24986178
44negative regulation of interleukin-1 beta production (GO:0032691)3.20028386
45positive regulation of guanylate cyclase activity (GO:0031284)3.15533248
46DNA-dependent DNA replication (GO:0006261)3.14918166
47sulfate transport (GO:0008272)3.14849167
48regulation of regulatory T cell differentiation (GO:0045589)3.14476135
49protein neddylation (GO:0045116)3.12150961
50regulation of RIG-I signaling pathway (GO:0039535)3.10180480
51embryonic hemopoiesis (GO:0035162)3.07764423
52neuron cell-cell adhesion (GO:0007158)3.05418226
53positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.03562947
54positive regulation of sodium ion transmembrane transport (GO:1902307)3.03535182
55cellular ketone body metabolic process (GO:0046950)3.03132877
56T cell mediated immunity (GO:0002456)2.96655344
57regulation of microtubule-based movement (GO:0060632)2.95191246
58regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.93607406
59antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.93503198
60cytidine catabolic process (GO:0006216)2.92135637
61cytidine deamination (GO:0009972)2.92135637
62cytidine metabolic process (GO:0046087)2.92135637
63mannosylation (GO:0097502)2.91765562
64mitochondrial respiratory chain complex assembly (GO:0033108)2.90373451
65negative regulation of telomere maintenance (GO:0032205)2.87997558
66protein K11-linked deubiquitination (GO:0035871)2.86674353
67auditory receptor cell stereocilium organization (GO:0060088)2.86179020
68tRNA processing (GO:0008033)2.85926845
69positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.84867953
70G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.82302069
71protein deneddylation (GO:0000338)2.81294662
72negative regulation of mast cell activation (GO:0033004)2.79751648
73arginine catabolic process (GO:0006527)2.79241024
74transepithelial transport (GO:0070633)2.78506248
75regulation of guanylate cyclase activity (GO:0031282)2.77830921
76myotube differentiation (GO:0014902)2.77570360
77negative regulation of organelle assembly (GO:1902116)2.75312868
78platelet dense granule organization (GO:0060155)2.74834154
79presynaptic membrane organization (GO:0097090)2.72510957
80regulation of rhodopsin mediated signaling pathway (GO:0022400)2.72345850
81adenosine metabolic process (GO:0046085)2.72278818
82rhodopsin mediated signaling pathway (GO:0016056)2.68894171
83positive regulation of natural killer cell mediated immunity (GO:0002717)2.67739998
84regulation of tolerance induction (GO:0002643)2.65232972
85neural tube formation (GO:0001841)2.64733024
86piRNA metabolic process (GO:0034587)2.64612569
87ketone body metabolic process (GO:1902224)2.64436172
88pericardium development (GO:0060039)2.63901767
89gamma-aminobutyric acid transport (GO:0015812)2.63703744
90head development (GO:0060322)2.63512158
91DNA double-strand break processing (GO:0000729)2.62509602
92negative regulation of interleukin-12 production (GO:0032695)2.62459954
93antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.61809354
94positive regulation of protein homooligomerization (GO:0032464)2.61551648
95positive regulation of natural killer cell differentiation (GO:0032825)2.60486007
96negative regulation of interleukin-1 production (GO:0032692)2.58247846
97epithelial cilium movement (GO:0003351)2.58003443
98regulation of isotype switching to IgG isotypes (GO:0048302)2.57500608
99regulation of meiosis I (GO:0060631)2.57094892
100urinary tract smooth muscle contraction (GO:0014848)2.56298186

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.62454621
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.60279837
3VDR_22108803_ChIP-Seq_LS180_Human3.18530689
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.92509979
5IGF1R_20145208_ChIP-Seq_DFB_Human2.91376947
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.69951429
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.64464104
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.55844655
9GBX2_23144817_ChIP-Seq_PC3_Human2.51733867
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.25085384
11EWS_26573619_Chip-Seq_HEK293_Human2.24624969
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.24466114
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.21354992
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.18138934
15GATA1_22025678_ChIP-Seq_K562_Human2.06633972
16P300_19829295_ChIP-Seq_ESCs_Human2.06032971
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.03339514
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.01007334
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.98239617
20ER_23166858_ChIP-Seq_MCF-7_Human1.97628087
21UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.92028793
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83412722
23FUS_26573619_Chip-Seq_HEK293_Human1.80596001
24PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.80510870
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.77391760
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.74144234
27TAF15_26573619_Chip-Seq_HEK293_Human1.73449924
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.71254921
29PCGF2_27294783_Chip-Seq_NPCs_Mouse1.66687637
30SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.65701681
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.64097884
32SMAD4_21799915_ChIP-Seq_A2780_Human1.63984732
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.62470572
34TP53_22573176_ChIP-Seq_HFKS_Human1.61085585
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.57132498
36CBP_20019798_ChIP-Seq_JUKART_Human1.54608907
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54608907
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50729478
39BCAT_22108803_ChIP-Seq_LS180_Human1.48690386
40KLF5_20875108_ChIP-Seq_MESCs_Mouse1.48300716
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47495036
42OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47169295
43FOXA1_27270436_Chip-Seq_PROSTATE_Human1.45431640
44FOXA1_25329375_ChIP-Seq_VCAP_Human1.45431640
45STAT3_23295773_ChIP-Seq_U87_Human1.45414419
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45098162
47MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44397575
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.43460167
49NFE2_27457419_Chip-Seq_LIVER_Mouse1.42439267
50AR_25329375_ChIP-Seq_VCAP_Human1.41608129
51NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.39215985
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39145131
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.38681929
54TCF4_23295773_ChIP-Seq_U87_Human1.38190358
55TCF4_22108803_ChIP-Seq_LS180_Human1.37586164
56EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.35806539
57ELK1_19687146_ChIP-ChIP_HELA_Human1.35149005
58SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35024964
59SOX2_19829295_ChIP-Seq_ESCs_Human1.34310532
60NANOG_19829295_ChIP-Seq_ESCs_Human1.34310532
61IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.34308100
62SMAD4_21741376_ChIP-Seq_EPCs_Human1.33407623
63FOXA1_21572438_ChIP-Seq_LNCaP_Human1.33248763
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.32132271
65HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.31773923
66PRDM14_20953172_ChIP-Seq_ESCs_Human1.29160335
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.29073976
68CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.28791394
69VDR_23849224_ChIP-Seq_CD4+_Human1.25585049
70CRX_20693478_ChIP-Seq_RETINA_Mouse1.24441037
71FLI1_21867929_ChIP-Seq_TH2_Mouse1.24004087
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23710164
73GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.20873746
74BP1_19119308_ChIP-ChIP_Hs578T_Human1.18012695
75NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17943718
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16508710
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16508710
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16036189
79REST_21632747_ChIP-Seq_MESCs_Mouse1.15241112
80HOXB7_26014856_ChIP-Seq_BT474_Human1.11513270
81GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09333025
82LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06858511
83AR_20517297_ChIP-Seq_VCAP_Human1.06196405
84CDX2_22108803_ChIP-Seq_LS180_Human1.06174823
85AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05596080
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.04255298
87NCOR_22424771_ChIP-Seq_293T_Human1.03582747
88SALL4_22934838_ChIP-ChIP_CD34+_Human1.00354756
89MYC_18940864_ChIP-ChIP_HL60_Human0.99761771
90NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99678890
91FOXH1_21741376_ChIP-Seq_EPCs_Human0.99636098
92GATA3_21878914_ChIP-Seq_MCF-7_Human0.99332144
93OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98427075
94SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.98401038
95TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98354428
96RUNX2_22187159_ChIP-Seq_PCA_Human0.96133228
97GATA3_26560356_Chip-Seq_TH2_Human0.95916235
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95482578
99P53_22387025_ChIP-Seq_ESCs_Mouse0.94322001
100KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.93837433

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level5.28665382
2MP0005167_abnormal_blood-brain_barrier4.51658178
3MP0003646_muscle_fatigue3.93831719
4MP0002163_abnormal_gland_morphology3.48362937
5MP0001348_abnormal_lacrimal_gland3.22582207
6MP0002102_abnormal_ear_morphology3.14379763
7MP0005379_endocrine/exocrine_gland_phen2.65529497
8MP0002735_abnormal_chemical_nociception2.54820866
9MP0003718_maternal_effect2.41456278
10MP0008872_abnormal_physiological_respon2.36125721
11MP0000569_abnormal_digit_pigmentation2.26857575
12MP0002234_abnormal_pharynx_morphology2.24771774
13MP0002837_dystrophic_cardiac_calcinosis2.15084455
14MP0005551_abnormal_eye_electrophysiolog2.14037592
15MP0004043_abnormal_pH_regulation2.08319443
16MP0002876_abnormal_thyroid_physiology2.05440981
17MP0003880_abnormal_central_pattern2.03074262
18MP0004084_abnormal_cardiac_muscle1.93879755
19MP0008877_abnormal_DNA_methylation1.91641927
20MP0002736_abnormal_nociception_after1.91534440
21MP0001346_abnormal_lacrimal_gland1.91153088
22MP0002638_abnormal_pupillary_reflex1.88231828
23MP0005360_urolithiasis1.72305576
24MP0001529_abnormal_vocalization1.69383086
25MP0004885_abnormal_endolymph1.67750148
26MP0001968_abnormal_touch/_nociception1.64466419
27MP0006082_CNS_inflammation1.61129147
28MP0003119_abnormal_digestive_system1.60716474
29MP0002653_abnormal_ependyma_morphology1.55058615
30MP0003195_calcinosis1.54190929
31MP0005253_abnormal_eye_physiology1.53030407
32MP0001986_abnormal_taste_sensitivity1.48864716
33MP0005671_abnormal_response_to1.48784578
34MP0001984_abnormal_olfaction1.44578334
35MP0005646_abnormal_pituitary_gland1.38546833
36MP0005645_abnormal_hypothalamus_physiol1.38397524
37MP0002138_abnormal_hepatobiliary_system1.35907235
38MP0006276_abnormal_autonomic_nervous1.35851902
39MP0009745_abnormal_behavioral_response1.27547957
40MP0004142_abnormal_muscle_tone1.26759615
41MP0002272_abnormal_nervous_system1.25883719
42MP0001970_abnormal_pain_threshold1.24263395
43MP0004036_abnormal_muscle_relaxation1.22117248
44MP0004742_abnormal_vestibular_system1.19429414
45MP0002733_abnormal_thermal_nociception1.19121438
46MP0002166_altered_tumor_susceptibility1.18957013
47MP0008875_abnormal_xenobiotic_pharmacok1.16404173
48MP0008775_abnormal_heart_ventricle1.11375462
49MP0002734_abnormal_mechanical_nocicepti1.11217442
50MP0001486_abnormal_startle_reflex1.10439499
51MP0005386_behavior/neurological_phenoty1.08965139
52MP0004924_abnormal_behavior1.08965139
53MP0005310_abnormal_salivary_gland1.03713061
54MP0000631_abnormal_neuroendocrine_gland1.03699350
55MP0000538_abnormal_urinary_bladder1.00677908
56MP0002751_abnormal_autonomic_nervous1.00646731
57MP0001501_abnormal_sleep_pattern1.00003578
58MP0002254_reproductive_system_inflammat0.95013864
59MP0008789_abnormal_olfactory_epithelium0.94688277
60MP0001873_stomach_inflammation0.89085827
61MP0000383_abnormal_hair_follicle0.88819678
62MP0004085_abnormal_heartbeat0.87838475
63MP0003137_abnormal_impulse_conducting0.87628069
64MP0006292_abnormal_olfactory_placode0.87206165
65MP0009046_muscle_twitch0.84152445
66MP0005395_other_phenotype0.84037194
67MP0003567_abnormal_fetal_cardiomyocyte0.81106085
68MP0001764_abnormal_homeostasis0.80787094
69MP0001835_abnormal_antigen_presentation0.80425135
70MP0002009_preneoplasia0.80244307
71MP0002006_tumorigenesis0.78878360
72MP0002572_abnormal_emotion/affect_behav0.78800507
73MP0000516_abnormal_urinary_system0.77647215
74MP0005367_renal/urinary_system_phenotyp0.77647215
75MP0004130_abnormal_muscle_cell0.73278126
76MP0003787_abnormal_imprinting0.72073563
77MP0003943_abnormal_hepatobiliary_system0.67865954
78MP0003635_abnormal_synaptic_transmissio0.67670374
79MP0001756_abnormal_urination0.67201273
80MP0005084_abnormal_gallbladder_morpholo0.67000084
81MP0001919_abnormal_reproductive_system0.66498134
82MP0000230_abnormal_systemic_arterial0.66270954
83MP0003868_abnormal_feces_composition0.65941786
84MP0003890_abnormal_embryonic-extraembry0.65671273
85MP0009697_abnormal_copulation0.65615235
86MP0001544_abnormal_cardiovascular_syste0.65482540
87MP0005385_cardiovascular_system_phenoty0.65482540
88MP0009764_decreased_sensitivity_to0.65308819
89MP0005408_hypopigmentation0.64830160
90MP0005083_abnormal_biliary_tract0.64321255
91MP0006072_abnormal_retinal_apoptosis0.64266373
92MP0001485_abnormal_pinna_reflex0.64027002
93MP0002064_seizures0.63106641
94MP0002909_abnormal_adrenal_gland0.61650029
95MP0001440_abnormal_grooming_behavior0.61598883
96MP0005195_abnormal_posterior_eye0.61040308
97MP0006035_abnormal_mitochondrial_morpho0.60783341
98MP0009333_abnormal_splenocyte_physiolog0.59311149
99MP0002557_abnormal_social/conspecific_i0.59197598
100MP0004215_abnormal_myocardial_fiber0.57255548

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.66170087
2Pancreatic cysts (HP:0001737)4.44822204
33-Methylglutaconic aciduria (HP:0003535)4.18182072
4Abnormality of midbrain morphology (HP:0002418)3.98019469
5Molar tooth sign on MRI (HP:0002419)3.98019469
6Abnormal delayed hypersensitivity skin test (HP:0002963)3.73677118
7Microretrognathia (HP:0000308)3.67648175
8Pancreatic fibrosis (HP:0100732)3.64478176
9Type II lissencephaly (HP:0007260)3.57969389
10Congenital stationary night blindness (HP:0007642)3.46853773
11True hermaphroditism (HP:0010459)3.41441984
12Large eyes (HP:0001090)3.31798277
13Hyperventilation (HP:0002883)3.30179193
14Inability to walk (HP:0002540)3.06034882
15Autoimmune thrombocytopenia (HP:0001973)3.02949586
16Nephronophthisis (HP:0000090)2.98781041
17Aplasia/Hypoplasia of the sternum (HP:0006714)2.96969843
18Breast hypoplasia (HP:0003187)2.95993350
19Retinal dysplasia (HP:0007973)2.95018995
20Autoimmune hemolytic anemia (HP:0001890)2.92588688
21Abnormality of the renal cortex (HP:0011035)2.79141324
22Abnormality of the renal medulla (HP:0100957)2.76642337
23Abnormal biliary tract physiology (HP:0012439)2.70084977
24Bile duct proliferation (HP:0001408)2.70084977
25Pendular nystagmus (HP:0012043)2.64635045
26Cystic liver disease (HP:0006706)2.64021377
27Chorioretinal atrophy (HP:0000533)2.62945780
28Lissencephaly (HP:0001339)2.61635998
29Patellar aplasia (HP:0006443)2.61330055
30Azoospermia (HP:0000027)2.58560145
31Cerebellar dysplasia (HP:0007033)2.55773478
32Hypoproteinemia (HP:0003075)2.53198988
33Poor speech (HP:0002465)2.52913756
34Keratoconus (HP:0000563)2.52555364
35Increased corneal curvature (HP:0100692)2.52555364
36Abnormal ciliary motility (HP:0012262)2.48898758
37Acute necrotizing encephalopathy (HP:0006965)2.46327402
38Mitochondrial inheritance (HP:0001427)2.44197522
39Increased IgM level (HP:0003496)2.44089919
40Aplasia/Hypoplasia of the patella (HP:0006498)2.38673712
41Abnormal respiratory motile cilium morphology (HP:0005938)2.36342274
42Abnormal respiratory epithelium morphology (HP:0012253)2.36342274
43Increased CSF lactate (HP:0002490)2.30199810
44Eosinophilia (HP:0001880)2.29014424
45Acute encephalopathy (HP:0006846)2.28993919
46Progressive macrocephaly (HP:0004481)2.28099924
47Congenital, generalized hypertrichosis (HP:0004540)2.26437075
48Abolished electroretinogram (ERG) (HP:0000550)2.23927173
49Medial flaring of the eyebrow (HP:0010747)2.23345748
50Concave nail (HP:0001598)2.22867786
51Increased hepatocellular lipid droplets (HP:0006565)2.22040735
52Widely spaced teeth (HP:0000687)2.16756417
53Aplasia/Hypoplasia of the tongue (HP:0010295)2.15692934
54Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.08885444
55Occipital encephalocele (HP:0002085)2.08484183
56Absent speech (HP:0001344)2.08111718
57Attenuation of retinal blood vessels (HP:0007843)2.07942600
58Large for gestational age (HP:0001520)2.02335186
59Metabolic alkalosis (HP:0200114)2.01769694
60Optic nerve hypoplasia (HP:0000609)2.01378160
61Aplasia/Hypoplasia involving the musculature (HP:0001460)2.00967808
62Myokymia (HP:0002411)2.00647404
63Decreased electroretinogram (ERG) amplitude (HP:0000654)2.00512532
64Febrile seizures (HP:0002373)1.97748009
65Panhypogammaglobulinemia (HP:0003139)1.95506984
66Hepatocellular necrosis (HP:0001404)1.95034510
67Exertional dyspnea (HP:0002875)1.94739623
68Hypochromic anemia (HP:0001931)1.94423428
69Elevated erythrocyte sedimentation rate (HP:0003565)1.93634096
70Neoplasm of the adrenal cortex (HP:0100641)1.92188296
71Abnormal respiratory motile cilium physiology (HP:0012261)1.90645034
72Lipid accumulation in hepatocytes (HP:0006561)1.90249365
73Progressive inability to walk (HP:0002505)1.90201088
74Furrowed tongue (HP:0000221)1.89312194
75Abnormal mitochondria in muscle tissue (HP:0008316)1.89193949
76Optic disc pallor (HP:0000543)1.87730227
77Abnormality of eosinophils (HP:0001879)1.86592861
78Polyuria (HP:0000103)1.86068122
79Hypokalemic alkalosis (HP:0001949)1.86052227
80Abnormality of the pons (HP:0007361)1.85492652
81Aqueductal stenosis (HP:0002410)1.84620540
82Chronic sinusitis (HP:0011109)1.84459798
83Bicuspid aortic valve (HP:0001647)1.82227057
84Pulmonary infiltrates (HP:0002113)1.81958484
85Abnormality of T cell number (HP:0011839)1.81168238
86Male pseudohermaphroditism (HP:0000037)1.80165188
87Abnormality of T cell physiology (HP:0011840)1.80013514
88Gait imbalance (HP:0002141)1.79993890
89Short chin (HP:0000331)1.79690338
90Absent/shortened dynein arms (HP:0200106)1.79251289
91Dynein arm defect of respiratory motile cilia (HP:0012255)1.79251289
92Abnormality of the labia minora (HP:0012880)1.78686916
93Aplasia/hypoplasia of the uterus (HP:0008684)1.78095480
94Abnormality of chloride homeostasis (HP:0011422)1.77405462
95Chronic hepatic failure (HP:0100626)1.77356795
96Abnormality of the metopic suture (HP:0005556)1.76908354
97Congenital primary aphakia (HP:0007707)1.76907294
98Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.76017447
99Hypoalbuminemia (HP:0003073)1.75696850
100Abnormal albumin level (HP:0012116)1.75696850

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.92880848
2ACVR1B4.78900241
3TIE14.52097015
4BMPR1B3.49767306
5CASK3.41625422
6BCR3.40884972
7DAPK22.98094437
8STK38L2.66297588
9TGFBR22.42105616
10PDK22.25454993
11ZAK2.16620775
12TGFBR11.93811552
13TRIM281.92128665
14WNK31.91706873
15NME11.89188447
16NUAK11.84323295
17GRK11.78198629
18FER1.73019215
19ADRBK21.64545219
20TEC1.55873496
21MAPK131.49553073
22PAK31.36417814
23EPHA41.35632535
24CDK81.27754684
25TNK21.27627798
26TXK1.23884640
27BCKDK1.15349520
28TAOK31.12533405
29MKNK21.12429969
30CAMKK21.07981139
31TSSK61.07711214
32FES1.03641890
33PINK11.01092840
34WNK40.95237957
35MARK10.92491758
36PTK2B0.91633710
37MAP3K40.91470571
38TLK10.90994372
39CAMKK10.89636134
40MAP2K60.85803210
41MAP4K20.83737760
42OXSR10.82693130
43NTRK20.79127913
44EPHB10.76764332
45MELK0.75576272
46ADRBK10.72925563
47CAMK2A0.71888414
48FGFR20.70635237
49STK380.70001796
50TNIK0.69472467
51BUB10.68012641
52STK160.67461727
53KSR10.65427696
54MAP2K70.64664898
55MARK30.61972431
56DYRK20.59669979
57WNK10.58985737
58NEK20.57255879
59PLK30.56963768
60CCNB10.56341474
61STK110.52667576
62INSRR0.51550483
63VRK10.50135590
64IKBKB0.49531786
65PRKCE0.49523472
66NEK60.48790876
67CAMK40.48242753
68CSNK1G10.42603610
69STK30.40311963
70ERBB30.39158513
71CDK190.37952216
72CAMK10.37668702
73CAMK2D0.37073771
74CSNK1G30.36577460
75EPHA30.36366195
76MUSK0.36236782
77MST40.36009732
78AKT30.35658336
79CSNK1A10.32045087
80CSNK1G20.31836601
81ITK0.31823870
82LYN0.31670703
83PRKCZ0.31097953
84MINK10.30653332
85MKNK10.29923434
86CSNK1A1L0.29915417
87FGR0.28908881
88EIF2AK30.26088505
89STK390.25894697
90KDR0.25696280
91BRSK20.25662788
92PRKACA0.25358768
93STK40.25259545
94UHMK10.25168799
95PLK20.24728422
96NLK0.24677488
97PRKCQ0.24160198
98MAP3K70.23745213
99RPS6KA50.22158890
100LATS10.19877986

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.23958492
2Protein export_Homo sapiens_hsa030603.09085939
3Phototransduction_Homo sapiens_hsa047442.93989731
4Non-homologous end-joining_Homo sapiens_hsa034502.63617963
5Nitrogen metabolism_Homo sapiens_hsa009102.41565377
6Oxidative phosphorylation_Homo sapiens_hsa001902.21201802
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.21039255
8Caffeine metabolism_Homo sapiens_hsa002322.12712895
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.10626940
10Nicotine addiction_Homo sapiens_hsa050332.08351486
11Propanoate metabolism_Homo sapiens_hsa006402.00178973
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.97101687
13Butanoate metabolism_Homo sapiens_hsa006501.92198990
14Linoleic acid metabolism_Homo sapiens_hsa005911.86585641
15Proteasome_Homo sapiens_hsa030501.79278286
16Mineral absorption_Homo sapiens_hsa049781.75556711
17Olfactory transduction_Homo sapiens_hsa047401.58453581
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.52880169
19GABAergic synapse_Homo sapiens_hsa047271.51284348
20Parkinsons disease_Homo sapiens_hsa050121.45211635
21Fanconi anemia pathway_Homo sapiens_hsa034601.43880964
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.43622672
23ABC transporters_Homo sapiens_hsa020101.38060309
24Nucleotide excision repair_Homo sapiens_hsa034201.33939475
25Taste transduction_Homo sapiens_hsa047421.32903068
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.31834364
27Graft-versus-host disease_Homo sapiens_hsa053321.31793011
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.29212037
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.28906084
30Primary immunodeficiency_Homo sapiens_hsa053401.27811102
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.24853716
32Glycerolipid metabolism_Homo sapiens_hsa005611.24843278
33Collecting duct acid secretion_Homo sapiens_hsa049661.24307846
34Selenocompound metabolism_Homo sapiens_hsa004501.23683186
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.20480323
36Autoimmune thyroid disease_Homo sapiens_hsa053201.20468042
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20173211
38Basal transcription factors_Homo sapiens_hsa030221.18877975
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.18249512
40RNA degradation_Homo sapiens_hsa030181.16014089
41Tryptophan metabolism_Homo sapiens_hsa003801.15495066
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.12467189
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11815552
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.11404071
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.11264740
46Retinol metabolism_Homo sapiens_hsa008301.05162064
47Allograft rejection_Homo sapiens_hsa053301.03888435
48Alzheimers disease_Homo sapiens_hsa050101.00029990
49Type I diabetes mellitus_Homo sapiens_hsa049400.98457823
50Huntingtons disease_Homo sapiens_hsa050160.95429735
51RNA polymerase_Homo sapiens_hsa030200.91877049
52Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.89501044
53Chemical carcinogenesis_Homo sapiens_hsa052040.89041038
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.87075831
55RNA transport_Homo sapiens_hsa030130.86490448
56Morphine addiction_Homo sapiens_hsa050320.86237453
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85773822
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.83698681
59Cardiac muscle contraction_Homo sapiens_hsa042600.83614848
60Circadian entrainment_Homo sapiens_hsa047130.81285674
61Ether lipid metabolism_Homo sapiens_hsa005650.80951214
62Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.77362951
63Hematopoietic cell lineage_Homo sapiens_hsa046400.76608834
64Serotonergic synapse_Homo sapiens_hsa047260.74375919
65Rheumatoid arthritis_Homo sapiens_hsa053230.73051277
66Glutamatergic synapse_Homo sapiens_hsa047240.70448248
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.67774672
68Regulation of autophagy_Homo sapiens_hsa041400.66978219
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66762364
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66113647
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65977811
72Pyruvate metabolism_Homo sapiens_hsa006200.64862366
73Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64213372
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63964669
75Insulin secretion_Homo sapiens_hsa049110.63768637
76Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.59480556
77Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58505234
78TGF-beta signaling pathway_Homo sapiens_hsa043500.54382340
79beta-Alanine metabolism_Homo sapiens_hsa004100.52752801
80Antigen processing and presentation_Homo sapiens_hsa046120.52693061
81African trypanosomiasis_Homo sapiens_hsa051430.52503235
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.52211920
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.51222505
84p53 signaling pathway_Homo sapiens_hsa041150.49761544
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48567758
86Peroxisome_Homo sapiens_hsa041460.46962452
87Metabolic pathways_Homo sapiens_hsa011000.45967868
88Amphetamine addiction_Homo sapiens_hsa050310.43092498
89T cell receptor signaling pathway_Homo sapiens_hsa046600.43053664
90Fatty acid elongation_Homo sapiens_hsa000620.43039271
91Asthma_Homo sapiens_hsa053100.42543419
92Calcium signaling pathway_Homo sapiens_hsa040200.41962270
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41320095
94Fatty acid degradation_Homo sapiens_hsa000710.40579421
95Fatty acid biosynthesis_Homo sapiens_hsa000610.39750494
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37870103
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37267440
98mRNA surveillance pathway_Homo sapiens_hsa030150.37071830
99Arachidonic acid metabolism_Homo sapiens_hsa005900.33862227
100Histidine metabolism_Homo sapiens_hsa003400.33274149

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