DEAF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a zinc finger domain-containing protein that functions as a regulator of transcription. The encoded proteins binds to its own promoter as well as to that of several target genes. Activity of this protein is important in the regulation of embryonic development. Mutations in this gene have been found in individuals with autosomal dominant mental retardation. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)6.00947956
2neuron cell-cell adhesion (GO:0007158)5.65336983
3pyrimidine nucleobase catabolic process (GO:0006208)5.38651965
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.92276127
5protein localization to synapse (GO:0035418)4.89224226
6regulation of short-term neuronal synaptic plasticity (GO:0048172)4.82641447
7negative regulation of microtubule polymerization (GO:0031115)4.68527840
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.60941564
9synaptic vesicle maturation (GO:0016188)4.56551170
10establishment of mitochondrion localization (GO:0051654)4.49245804
11locomotory exploration behavior (GO:0035641)4.39969895
12postsynaptic membrane organization (GO:0001941)4.36075551
13exploration behavior (GO:0035640)4.35679013
14cellular potassium ion homeostasis (GO:0030007)4.32315705
15regulation of synaptic vesicle exocytosis (GO:2000300)4.31410354
16vocalization behavior (GO:0071625)4.29029632
17positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.24160050
18mitochondrion transport along microtubule (GO:0047497)4.15784044
19establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.15784044
20sodium ion export (GO:0071436)4.15778733
21central nervous system projection neuron axonogenesis (GO:0021952)4.14627672
22synaptic vesicle exocytosis (GO:0016079)4.14027762
23layer formation in cerebral cortex (GO:0021819)4.11064712
24membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.02994932
25glutamate secretion (GO:0014047)3.99551053
26positive regulation of dendritic spine morphogenesis (GO:0061003)3.95430704
27positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.94909511
28neuron recognition (GO:0008038)3.93059867
29cell migration in hindbrain (GO:0021535)3.90580606
30nucleobase catabolic process (GO:0046113)3.85950822
31regulation of glutamate receptor signaling pathway (GO:1900449)3.85865588
32dendritic spine morphogenesis (GO:0060997)3.85415010
33positive regulation of synapse maturation (GO:0090129)3.81374475
34dendrite morphogenesis (GO:0048813)3.80323716
35cerebellar granule cell differentiation (GO:0021707)3.75714689
36regulation of synaptic vesicle transport (GO:1902803)3.74786724
37neuromuscular process controlling balance (GO:0050885)3.73780417
38positive regulation of synaptic transmission, GABAergic (GO:0032230)3.71908217
39regulation of synapse structural plasticity (GO:0051823)3.69181391
40regulation of female receptivity (GO:0045924)3.68794162
41regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.64738998
42regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.62927029
43regulation of synaptic plasticity (GO:0048167)3.58684995
44auditory behavior (GO:0031223)3.55883060
45axonal fasciculation (GO:0007413)3.54650140
46synaptic transmission, glutamatergic (GO:0035249)3.51935080
47L-amino acid import (GO:0043092)3.50930997
48ionotropic glutamate receptor signaling pathway (GO:0035235)3.50662931
49deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.50057507
50presynaptic membrane assembly (GO:0097105)3.48813876
51G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.45652275
52amino acid import (GO:0043090)3.41438731
53regulation of ARF protein signal transduction (GO:0032012)3.40853726
54regulation of neuronal synaptic plasticity (GO:0048168)3.37778859
55synaptic vesicle docking involved in exocytosis (GO:0016081)3.37208325
56nucleotide salvage (GO:0043173)3.36462581
57regulation of respiratory system process (GO:0044065)3.32595211
58positive regulation of dendritic spine development (GO:0060999)3.30947515
59female mating behavior (GO:0060180)3.29591620
60positive regulation of membrane potential (GO:0045838)3.28090805
61regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.27219631
62positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.26259608
63regulation of neurotransmitter levels (GO:0001505)3.23971646
64response to auditory stimulus (GO:0010996)3.22371783
65glutamate receptor signaling pathway (GO:0007215)3.19414792
66dopamine receptor signaling pathway (GO:0007212)3.17523953
67neurotransmitter secretion (GO:0007269)3.17294797
68regulation of respiratory gaseous exchange (GO:0043576)3.16348007
69regulation of long-term neuronal synaptic plasticity (GO:0048169)3.15959920
70potassium ion homeostasis (GO:0055075)3.15261840
71presynaptic membrane organization (GO:0097090)3.15096356
72regulation of synapse maturation (GO:0090128)3.14412355
73cerebellum development (GO:0021549)3.13387705
74synapse assembly (GO:0007416)3.11763545
75regulation of voltage-gated calcium channel activity (GO:1901385)3.11646695
76positive regulation of neurotransmitter transport (GO:0051590)3.11475379
77positive regulation of synapse assembly (GO:0051965)3.09509634
78neuronal action potential propagation (GO:0019227)3.08346706
79cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.08206236
80synaptic vesicle endocytosis (GO:0048488)3.07711290
81central nervous system neuron axonogenesis (GO:0021955)3.06025499
82membrane hyperpolarization (GO:0060081)3.05272779
83axon ensheathment in central nervous system (GO:0032291)3.04476577
84central nervous system myelination (GO:0022010)3.04476577
85negative regulation of erythrocyte differentiation (GO:0045647)3.00588643
86neurotransmitter-gated ion channel clustering (GO:0072578)2.99153298
87negative regulation of dendrite morphogenesis (GO:0050774)2.96711234
88neuron-neuron synaptic transmission (GO:0007270)2.96014686
89innervation (GO:0060384)2.95648815
90regulation of microtubule polymerization (GO:0031113)2.95293611
91dendritic spine organization (GO:0097061)2.94390837
92clathrin coat assembly (GO:0048268)2.93409579
93proline transport (GO:0015824)2.93251134
94mechanosensory behavior (GO:0007638)2.92767515
95long-term memory (GO:0007616)2.92177260
96acidic amino acid transport (GO:0015800)2.87928200
97social behavior (GO:0035176)2.86128870
98intraspecies interaction between organisms (GO:0051703)2.86128870
99positive regulation of neurotransmitter secretion (GO:0001956)2.85709827
100regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.84572999
101dicarboxylic acid transport (GO:0006835)2.83035702
102regulation of neurotransmitter secretion (GO:0046928)2.81849599
103potassium ion import (GO:0010107)2.78147518
104regulation of vesicle fusion (GO:0031338)2.77814377
105transmission of nerve impulse (GO:0019226)2.77529203
1062-deoxyribonucleotide biosynthetic process (GO:0009265)2.76546506
107deoxyribose phosphate biosynthetic process (GO:0046385)2.76546506
108cell communication by electrical coupling (GO:0010644)2.71927763
109regulation of synaptic transmission (GO:0050804)2.71645029
110neurotransmitter transport (GO:0006836)2.71446155
111neuronal ion channel clustering (GO:0045161)2.70743014
112righting reflex (GO:0060013)2.70329537
113neuromuscular process (GO:0050905)2.70013738
114cerebral cortex radially oriented cell migration (GO:0021799)2.69997438
115regulation of dendritic spine morphogenesis (GO:0061001)2.68581375
116glycine transport (GO:0015816)2.67730140
117mating behavior (GO:0007617)2.67406738
118axon cargo transport (GO:0008088)2.65694360
119axon extension (GO:0048675)2.65568061
120activation of protein kinase A activity (GO:0034199)2.65508109
121organelle transport along microtubule (GO:0072384)2.64479136
122regulation of dendritic spine development (GO:0060998)2.63826466
123homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.62681793
124positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.62561453
125gamma-aminobutyric acid transport (GO:0015812)2.61938434
126hippocampus development (GO:0021766)2.61927039
127positive regulation of dendrite development (GO:1900006)2.61871276
128regulation of glycogen (starch) synthase activity (GO:2000465)2.61668498
129L-glutamate transport (GO:0015813)2.61574719
130detection of temperature stimulus involved in sensory perception (GO:0050961)2.61073945
131detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.61073945
132regulation of synapse organization (GO:0050807)2.60407496
133neuromuscular synaptic transmission (GO:0007274)2.59293965
134regulation of excitatory postsynaptic membrane potential (GO:0060079)2.59243887
135synapse organization (GO:0050808)2.58679862
136regulation of calcium ion-dependent exocytosis (GO:0017158)2.57963252
137cerebellar Purkinje cell layer development (GO:0021680)2.57426860
138phosphorelay signal transduction system (GO:0000160)2.57227572
139dendrite development (GO:0016358)2.56388462
140regulation of postsynaptic membrane potential (GO:0060078)2.54840126
141regulation of synapse assembly (GO:0051963)2.54567335
142regulation of neurotransmitter transport (GO:0051588)2.52339413
143neuron migration (GO:0001764)2.50997222
144startle response (GO:0001964)2.50254599
145peptidyl-arginine omega-N-methylation (GO:0035247)2.49826012
146viral mRNA export from host cell nucleus (GO:0046784)2.49386796

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.74314376
2CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.77399535
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.42898694
4GBX2_23144817_ChIP-Seq_PC3_Human3.39680183
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.09159357
6REST_21632747_ChIP-Seq_MESCs_Mouse2.98633638
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.93825002
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.85955689
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.79698456
10LXR_22292898_ChIP-Seq_THP-1_Human2.70995135
11EZH2_27294783_Chip-Seq_ESCs_Mouse2.70231375
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.58472491
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.54304569
14SUZ12_27294783_Chip-Seq_ESCs_Mouse2.51731752
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.47406262
16REST_18959480_ChIP-ChIP_MESCs_Mouse2.46696289
17DROSHA_22980978_ChIP-Seq_HELA_Human2.44434395
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.42040539
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.42040539
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.39316784
21* RNF2_27304074_Chip-Seq_ESCs_Mouse2.34785605
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.33398844
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.29806960
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.28659325
25MTF2_20144788_ChIP-Seq_MESCs_Mouse2.23365911
26EED_16625203_ChIP-ChIP_MESCs_Mouse2.22964029
27VDR_21846776_ChIP-Seq_THP-1_Human2.16352187
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.12961404
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.10334533
30RARB_27405468_Chip-Seq_BRAIN_Mouse2.08921615
31* P68_20966046_ChIP-Seq_HELA_Human2.08921042
32KDM2B_26808549_Chip-Seq_SUP-B15_Human2.08825793
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.01197505
34TET1_21451524_ChIP-Seq_MESCs_Mouse1.98516056
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.98113007
36KDM2B_26808549_Chip-Seq_DND41_Human1.90480451
37SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.89694830
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85468646
39MYC_22102868_ChIP-Seq_BL_Human1.85320746
40SRY_22984422_ChIP-ChIP_TESTIS_Rat1.80125876
41CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.78908895
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.78180753
43EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.75076158
44IGF1R_20145208_ChIP-Seq_DFB_Human1.73312206
45ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.68345480
46ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.67946980
47OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.66681931
48SA1_27219007_Chip-Seq_ERYTHROID_Human1.66167594
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.63103997
50* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.58852494
51SMC4_20622854_ChIP-Seq_HELA_Human1.56172776
52RACK7_27058665_Chip-Seq_MCF-7_Human1.52443936
53CREB1_26743006_Chip-Seq_LNCaP_Human1.51916005
54RNF2_27304074_Chip-Seq_NSC_Mouse1.50570081
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.50351187
56KDM2B_26808549_Chip-Seq_JURKAT_Human1.50320229
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50316823
58ELF1_20517297_ChIP-Seq_JURKAT_Human1.49484510
59DNAJC2_21179169_ChIP-ChIP_NT2_Human1.49471243
60ELK3_25401928_ChIP-Seq_HUVEC_Human1.49000886
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47017745
62RING1B_27294783_Chip-Seq_ESCs_Mouse1.46866792
63SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.45840633
64SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44488045
65* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.44182289
66ZFP281_18757296_ChIP-ChIP_E14_Mouse1.44128363
67* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.41995097
68ERG_21242973_ChIP-ChIP_JURKAT_Human1.41629332
69RING1B_27294783_Chip-Seq_NPCs_Mouse1.40496564
70ZNF274_21170338_ChIP-Seq_K562_Hela1.39019569
71STAT6_21828071_ChIP-Seq_BEAS2B_Human1.38448805
72PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36411744
73ZFP57_27257070_Chip-Seq_ESCs_Mouse1.34972357
74CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.34619137
75TCF7_22412390_ChIP-Seq_EML_Mouse1.33013976
76CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.32383171
77* XRN2_22483619_ChIP-Seq_HELA_Human1.31238500
78* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.30488312
79PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.30340744
80RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.30130320
81DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.29466719
82CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.29203337
83BCL6_27268052_Chip-Seq_Bcells_Human1.26751906
84RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25271850
85HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.24148645
86KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.23763935
87BCOR_27268052_Chip-Seq_Bcells_Human1.20918704
88SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.20282867
89FOXP1_21924763_ChIP-Seq_HESCs_Human1.19858335
90OCT4_19829295_ChIP-Seq_ESCs_Human1.16623469
91* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.16342880
92ESR1_15608294_ChIP-ChIP_MCF-7_Human1.15503634
93MYC_18555785_ChIP-Seq_MESCs_Mouse1.15347564
94GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14922779
95TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.14880095
96AR_21572438_ChIP-Seq_LNCaP_Human1.14427476
97CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.13804170
98SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.13743354
99YY1_21170310_ChIP-Seq_MESCs_Mouse1.13151985
100ZNF263_19887448_ChIP-Seq_K562_Human1.12991331
101SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.11933416
102DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10849995
103SA1_27219007_Chip-Seq_Bcells_Human1.09876379
104KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09327604
105* CTCF_20526341_ChIP-Seq_ESCs_Human1.08342534
106KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07813258
107PHF8_20622854_ChIP-Seq_HELA_Human1.07233142
108RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.06007219
109TET1_21490601_ChIP-Seq_MESCs_Mouse1.05647934
110EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03143058
111* CTCF_27219007_Chip-Seq_Bcells_Human1.02073726
112AR_19668381_ChIP-Seq_PC3_Human0.99417741
113MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.98419930
114SMAD4_21799915_ChIP-Seq_A2780_Human0.95585704
115YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94211462
116CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93499983
117THAP11_20581084_ChIP-Seq_MESCs_Mouse0.92773001
118HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.92532724
119SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92167173
120KDM2B_26808549_Chip-Seq_K562_Human0.92162938
121POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90706565
122TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90706565
123OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89641006
124WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.89484392
125POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89181748
126SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89017526
127WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87409605
128STAT3_23295773_ChIP-Seq_U87_Human0.87391523
129TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86141570
130VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.86102009
131DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.85474828
132CTCF_18555785_ChIP-Seq_MESCs_Mouse0.84485174
133SOX2_21211035_ChIP-Seq_LN229_Gbm0.83691786
134CIITA_25753668_ChIP-Seq_RAJI_Human0.83501603
135NR3C1_23031785_ChIP-Seq_PC12_Mouse0.81918228
136POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.81871496
137SMAD3_21741376_ChIP-Seq_ESCs_Human0.81402700
138AR_25329375_ChIP-Seq_VCAP_Human0.80770475
139* TCF4_23295773_ChIP-Seq_U87_Human0.80303335
140P300_19829295_ChIP-Seq_ESCs_Human0.80246181
141SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.79253650
142ZFP281_27345836_Chip-Seq_ESCs_Mouse0.79210891
143GATA1_26923725_Chip-Seq_HPCs_Mouse0.78451794
144TP53_20018659_ChIP-ChIP_R1E_Mouse0.78094804
145MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.78037595
146TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.77967755
147TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.77408786
148E2F1_17053090_ChIP-ChIP_MCF-7_Human0.76967419
149TOP2B_26459242_ChIP-Seq_MCF-7_Human0.76948870
150SMAD3_21741376_ChIP-Seq_EPCs_Human0.76139849
151RUNX2_22187159_ChIP-Seq_PCA_Human0.75844261

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.34026201
2MP0003880_abnormal_central_pattern4.14360340
3MP0005423_abnormal_somatic_nervous3.75925478
4MP0004270_analgesia3.34585803
5MP0003635_abnormal_synaptic_transmissio3.24066237
6MP0000778_abnormal_nervous_system2.70287805
7MP0002063_abnormal_learning/memory/cond2.66536801
8MP0001968_abnormal_touch/_nociception2.37157439
9MP0002734_abnormal_mechanical_nocicepti2.36029040
10MP0001486_abnormal_startle_reflex2.28946369
11MP0001529_abnormal_vocalization2.28377275
12MP0009745_abnormal_behavioral_response2.28008007
13MP0003122_maternal_imprinting2.22215471
14MP0006276_abnormal_autonomic_nervous2.19743434
15MP0002184_abnormal_innervation2.16451650
16MP0002572_abnormal_emotion/affect_behav2.14847967
17MP0002733_abnormal_thermal_nociception2.10737110
18MP0002557_abnormal_social/conspecific_i2.05569052
19MP0002064_seizures2.03607109
20MP0002735_abnormal_chemical_nociception2.02552950
21MP0005645_abnormal_hypothalamus_physiol2.00134728
22MP0003787_abnormal_imprinting1.97559605
23MP0000955_abnormal_spinal_cord1.92814695
24MP0001188_hyperpigmentation1.92233073
25MP0002272_abnormal_nervous_system1.90254524
26MP0000569_abnormal_digit_pigmentation1.88747020
27MP0002822_catalepsy1.85534105
28MP0002249_abnormal_larynx_morphology1.81762412
29MP0005394_taste/olfaction_phenotype1.76944288
30MP0005499_abnormal_olfactory_system1.76944288
31MP0001970_abnormal_pain_threshold1.76813886
32MP0004885_abnormal_endolymph1.71210315
33MP0001346_abnormal_lacrimal_gland1.70906240
34MP0002736_abnormal_nociception_after1.69338159
35MP0002067_abnormal_sensory_capabilities1.68364219
36MP0004811_abnormal_neuron_physiology1.65556106
37MP0002938_white_spotting1.64319190
38MP0005386_behavior/neurological_phenoty1.59975937
39MP0004924_abnormal_behavior1.59975937
40MP0002882_abnormal_neuron_morphology1.55415662
41MP0006292_abnormal_olfactory_placode1.54508641
42MP0002638_abnormal_pupillary_reflex1.54166678
43MP0009046_muscle_twitch1.53848024
44MP0005646_abnormal_pituitary_gland1.53121963
45MP0008789_abnormal_olfactory_epithelium1.52661387
46MP0002234_abnormal_pharynx_morphology1.44181839
47MP0003329_amyloid_beta_deposits1.44150152
48MP0003121_genomic_imprinting1.43832877
49MP0001502_abnormal_circadian_rhythm1.40874871
50MP0001984_abnormal_olfaction1.39452715
51MP0000631_abnormal_neuroendocrine_gland1.34572740
52MP0006072_abnormal_retinal_apoptosis1.33941378
53* MP0002152_abnormal_brain_morphology1.33878226
54MP0008569_lethality_at_weaning1.32602224
55MP0001905_abnormal_dopamine_level1.32356779
56MP0000681_abnormal_thyroid_gland1.29278231
57MP0002066_abnormal_motor_capabilities/c1.27698485
58MP0004858_abnormal_nervous_system1.25296188
59MP0001440_abnormal_grooming_behavior1.25091341
60MP0005551_abnormal_eye_electrophysiolog1.22274385
61MP0000566_synostosis1.21877437
62MP0005623_abnormal_meninges_morphology1.21497597
63MP0003119_abnormal_digestive_system1.21077105
64MP0003879_abnormal_hair_cell1.19536566
65* MP0003861_abnormal_nervous_system1.19380024
66MP0001485_abnormal_pinna_reflex1.16923248
67MP0010386_abnormal_urinary_bladder1.14921011
68MP0009780_abnormal_chondrocyte_physiolo1.11170300
69MP0004742_abnormal_vestibular_system1.10861184
70MP0000920_abnormal_myelination1.10744092
71MP0002752_abnormal_somatic_nervous1.10218780
72MP0004142_abnormal_muscle_tone1.09560985
73MP0009278_abnormal_bone_marrow1.08923531
74MP0002751_abnormal_autonomic_nervous1.08564132
75MP0002102_abnormal_ear_morphology1.07663404
76MP0001348_abnormal_lacrimal_gland1.05881969
77MP0008961_abnormal_basal_metabolism1.03723528
78MP0002229_neurodegeneration1.03107174
79MP0002909_abnormal_adrenal_gland1.01212089
80MP0001963_abnormal_hearing_physiology0.97967538
81MP0002069_abnormal_eating/drinking_beha0.96186013
82MP0004147_increased_porphyrin_level0.94327124
83MP0001664_abnormal_digestion0.93439326
84MP0003690_abnormal_glial_cell0.92805541
85MP0000003_abnormal_adipose_tissue0.90609718
86MP0001501_abnormal_sleep_pattern0.90428194
87MP0003283_abnormal_digestive_organ0.90086084
88MP0009379_abnormal_foot_pigmentation0.88554649
89MP0000678_abnormal_parathyroid_gland0.87756719
90MP0000013_abnormal_adipose_tissue0.86096835
91MP0000026_abnormal_inner_ear0.85221489
92MP0004133_heterotaxia0.84280715
93MP0003123_paternal_imprinting0.84010543
94MP0005253_abnormal_eye_physiology0.82666527
95MP0000604_amyloidosis0.79448856
96MP0000015_abnormal_ear_pigmentation0.78681251
97MP0010770_preweaning_lethality0.75422346
98MP0002082_postnatal_lethality0.75422346
99MP0010769_abnormal_survival0.73052631
100MP0000537_abnormal_urethra_morphology0.72595458
101MP0003111_abnormal_nucleus_morphology0.72044010
102MP0010768_mortality/aging0.70957864
103MP0003634_abnormal_glial_cell0.70556506
104MP0003890_abnormal_embryonic-extraembry0.70463175
105MP0005084_abnormal_gallbladder_morpholo0.69070291
106* MP0002081_perinatal_lethality0.68898646
107MP0005174_abnormal_tail_pigmentation0.68815345
108MP0005409_darkened_coat_color0.68752072
109MP0003633_abnormal_nervous_system0.68728783
110MP0008874_decreased_physiological_sensi0.68368165
111MP0001177_atelectasis0.68340470
112MP0001944_abnormal_pancreas_morphology0.67909907
113MP0005220_abnormal_exocrine_pancreas0.67614808
114MP0000462_abnormal_digestive_system0.67458129
115MP0002089_abnormal_postnatal_growth/wei0.67413918
116MP0003942_abnormal_urinary_system0.66562824
117MP0002873_normal_phenotype0.66199740
118MP0003631_nervous_system_phenotype0.66168370
119MP0000049_abnormal_middle_ear0.65309049
120MP0002169_no_abnormal_phenotype0.64908883
121MP0009672_abnormal_birth_weight0.64807260
122MP0005058_abnormal_lysosome_morphology0.64555984
123MP0003172_abnormal_lysosome_physiology0.61029299
124MP0003956_abnormal_body_size0.59636397
125MP0001731_abnormal_postnatal_growth0.57931350
126MP0002163_abnormal_gland_morphology0.57914761
127MP0003137_abnormal_impulse_conducting0.56099600
128MP0005535_abnormal_body_temperature0.55623911
129MP0001943_abnormal_respiration0.55531930
130MP0003075_altered_response_to0.54183227
131MP0006036_abnormal_mitochondrial_physio0.53954142
132MP0003938_abnormal_ear_development0.53894447

Predicted human phenotypes

RankGene SetZ-score
1Epileptic encephalopathy (HP:0200134)4.58659130
2Myokymia (HP:0002411)4.07088035
3Annular pancreas (HP:0001734)3.80190723
4Visual hallucinations (HP:0002367)3.79654990
5Limb dystonia (HP:0002451)3.69382688
6Mutism (HP:0002300)3.59687225
7Ankle clonus (HP:0011448)3.56938239
8Lissencephaly (HP:0001339)3.49880123
9Supranuclear gaze palsy (HP:0000605)3.46866253
10Truncus arteriosus (HP:0001660)3.32513990
11Hyperthyroidism (HP:0000836)3.31876599
12Diplopia (HP:0000651)3.31096350
13Abnormality of binocular vision (HP:0011514)3.31096350
14EEG with generalized epileptiform discharges (HP:0011198)3.08464174
15Focal seizures (HP:0007359)3.06218603
16Tetraplegia (HP:0002445)3.06078269
17Focal motor seizures (HP:0011153)3.04251947
18Hypsarrhythmia (HP:0002521)3.00199994
19Epileptiform EEG discharges (HP:0011182)2.99866881
20Agitation (HP:0000713)2.96363909
21Insomnia (HP:0100785)2.92914895
22Delusions (HP:0000746)2.89940447
23Amyotrophic lateral sclerosis (HP:0007354)2.88866907
24Progressive cerebellar ataxia (HP:0002073)2.87715055
25Broad distal phalanx of finger (HP:0009836)2.81692983
26Peripheral hypomyelination (HP:0007182)2.79955840
27Retinal dysplasia (HP:0007973)2.76828214
28Aplasia/Hypoplasia of the brainstem (HP:0007362)2.75641145
29Hypoplasia of the brainstem (HP:0002365)2.75641145
30Abnormality of the lower motor neuron (HP:0002366)2.74222661
31Akinesia (HP:0002304)2.68460174
32Abnormality of the corticospinal tract (HP:0002492)2.66863591
33Elfin facies (HP:0004428)2.64592763
34Febrile seizures (HP:0002373)2.64128174
35Broad-based gait (HP:0002136)2.60324007
36Pointed chin (HP:0000307)2.59335503
37Polyphagia (HP:0002591)2.59046554
38Protruding tongue (HP:0010808)2.56010082
39Abnormality of the aortic arch (HP:0012303)2.55402357
40Impaired smooth pursuit (HP:0007772)2.55339673
41Type II lissencephaly (HP:0007260)2.55011534
42Optic nerve hypoplasia (HP:0000609)2.53133766
43Abnormal gallbladder physiology (HP:0012438)2.50875274
44Cholecystitis (HP:0001082)2.50875274
45Excessive salivation (HP:0003781)2.50175701
46Drooling (HP:0002307)2.50175701
47Dysmetria (HP:0001310)2.44328335
48Depression (HP:0000716)2.43068172
49Pachygyria (HP:0001302)2.42580436
50Truncal ataxia (HP:0002078)2.39965319
51Neurofibrillary tangles (HP:0002185)2.38613542
52Achilles tendon contracture (HP:0001771)2.32375826
53Neuronal loss in central nervous system (HP:0002529)2.31628163
54Amblyopia (HP:0000646)2.29592645
55Atrophy/Degeneration involving motor neurons (HP:0007373)2.26766420
56Turricephaly (HP:0000262)2.24415817
57Dysphonia (HP:0001618)2.23961278
58Spinal canal stenosis (HP:0003416)2.23082599
59Action tremor (HP:0002345)2.22735908
60Lower limb asymmetry (HP:0100559)2.22107415
61Ependymoma (HP:0002888)2.19357944
62Abnormal ventriculo-arterial connection (HP:0011563)2.17003829
63Transposition of the great arteries (HP:0001669)2.17003829
64Abnormal connection of the cardiac segments (HP:0011545)2.17003829
65Unsteady gait (HP:0002317)2.16509396
66Spastic gait (HP:0002064)2.13048920
67Torticollis (HP:0000473)2.12879328
68Hyperacusis (HP:0010780)2.12202591
69Double outlet right ventricle (HP:0001719)2.11084683
70Congenital malformation of the right heart (HP:0011723)2.11084683
71Cerebral inclusion bodies (HP:0100314)2.09680940
72Focal dystonia (HP:0004373)2.09337456
73Tented upper lip vermilion (HP:0010804)2.08328899
74Absence seizures (HP:0002121)2.06995824
75Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.06801571
76Neoplasm of the heart (HP:0100544)2.04471090
77Atonic seizures (HP:0010819)2.04071059
78Postural instability (HP:0002172)2.02460526
79Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.02459674
80Generalized tonic-clonic seizures (HP:0002069)2.02319925
81Hemiparesis (HP:0001269)2.01857328
82Anxiety (HP:0000739)2.01171914
83Gait imbalance (HP:0002141)2.00873660
84Genetic anticipation (HP:0003743)2.00027344
85Septo-optic dysplasia (HP:0100842)1.98607056
86Poor suck (HP:0002033)1.98373781
87Deep palmar crease (HP:0006191)1.97368714
88Centrally nucleated skeletal muscle fibers (HP:0003687)1.96823722
89Muscular hypotonia of the trunk (HP:0008936)1.96730667
90Intention tremor (HP:0002080)1.95917733
91Abnormality of the astrocytes (HP:0100707)1.95715079
92Astrocytoma (HP:0009592)1.95715079
93Apathy (HP:0000741)1.95524159
94Absent speech (HP:0001344)1.95153606
95Athetosis (HP:0002305)1.94699313
96Intestinal atresia (HP:0011100)1.93642139
97Pancreatic islet-cell hyperplasia (HP:0004510)1.93184947
98Stereotypic behavior (HP:0000733)1.90884180
99Inappropriate behavior (HP:0000719)1.90476684
100Sporadic (HP:0003745)1.89775653
101CNS hypomyelination (HP:0003429)1.89086574
102Abnormality of the Achilles tendon (HP:0005109)1.88735664
103Renal duplication (HP:0000075)1.88694815
104Overriding aorta (HP:0002623)1.88530380
105Open mouth (HP:0000194)1.88443316
106Broad alveolar ridges (HP:0000187)1.87648918
107Dialeptic seizures (HP:0011146)1.86181111
108Abnormality of ocular smooth pursuit (HP:0000617)1.85457462
109Volvulus (HP:0002580)1.84568978
110Craniofacial dystonia (HP:0012179)1.84352512
111Abnormal eating behavior (HP:0100738)1.84277096
112Stridor (HP:0010307)1.84266983
113Hypoplasia of the corpus callosum (HP:0002079)1.84131876
114Papilledema (HP:0001085)1.83878211
115Severe visual impairment (HP:0001141)1.83566947
116Sleep apnea (HP:0010535)1.83405813
117Pheochromocytoma (HP:0002666)1.82950404
118Obstructive sleep apnea (HP:0002870)1.82861349
119Progressive microcephaly (HP:0000253)1.82236079
120* Poor eye contact (HP:0000817)1.82180920
121Scanning speech (HP:0002168)1.81553670
122Macroglossia (HP:0000158)1.80983194
123Absent rod-and cone-mediated responses on ERG (HP:0007688)1.80783459
124Rigidity (HP:0002063)1.80708896
125Bowel incontinence (HP:0002607)1.80084152
126Choreoathetosis (HP:0001266)1.79693313
127Megalencephaly (HP:0001355)1.76687484
128Morphological abnormality of the pyramidal tract (HP:0002062)1.76232067
129Flat cornea (HP:0007720)1.75638573
130Abnormality of cochlea (HP:0000375)1.75581376
131Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.75357541
132Dysmetric saccades (HP:0000641)1.74923411
133Fetal akinesia sequence (HP:0001989)1.74074298
134Foot dorsiflexor weakness (HP:0009027)1.74052086
135Aplasia of the phalanges of the hand (HP:0009802)1.73684510
136Aplasia involving bones of the extremities (HP:0009825)1.73684510
137Aplasia involving bones of the upper limbs (HP:0009823)1.73684510
138Large eyes (HP:0001090)1.73169558
139Renovascular hypertension (HP:0100817)1.72832738
140Bradykinesia (HP:0002067)1.72810586
141Restlessness (HP:0000711)1.71706409
142Abnormality of the periventricular white matter (HP:0002518)1.71633520
143Urinary bladder sphincter dysfunction (HP:0002839)1.71436867
144Ulnar bowing (HP:0003031)1.71110366
145Cerebral hypomyelination (HP:0006808)1.70948144
146Cortical visual impairment (HP:0100704)1.70862337
147Optic nerve coloboma (HP:0000588)1.70414868
148Morphological abnormality of the inner ear (HP:0011390)1.69748734
149Specific learning disability (HP:0001328)1.69333155
150Diminished motivation (HP:0000745)1.68354408
151Cerebellar hypoplasia (HP:0001321)1.67581870
152Gastroesophageal reflux (HP:0002020)1.64741361
153Shoulder girdle muscle weakness (HP:0003547)1.64637067
154Urinary urgency (HP:0000012)1.64053201

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK17.26664549
2CASK3.15402007
3NTRK32.98744509
4NTRK22.79067950
5TNIK2.68416638
6DYRK22.67131969
7ARAF2.51945227
8MAP2K72.47645134
9MAPK132.42425770
10MINK12.37715012
11MAP3K92.37320698
12MAP3K42.29190535
13TRIB32.25676937
14MAP3K112.02944667
15EEF2K1.96696114
16UHMK11.89560424
17DAPK21.86827041
18ERBB31.78732750
19SMG11.74678194
20NME21.74512914
21PHKG21.72884796
22PHKG11.72884796
23SIK21.68919141
24KDR1.68053349
25PAK61.66293824
26PRPF4B1.58269320
27BCKDK1.55456588
28INSRR1.55221846
29KSR11.53673060
30NTRK11.48589782
31BMPR1B1.40778175
32EPHA41.35680156
33DYRK1A1.34321200
34CDK51.31544371
35TIE11.23670148
36LATS21.18674182
37MAP3K131.13217336
38STK161.09971729
39TESK11.08867647
40LIMK11.08671374
41TSSK61.04710650
42MAPK121.04298538
43MARK21.04165627
44RIPK11.04018727
45DAPK11.03954943
46TESK21.02782008
47CDK191.02310173
48VRK21.00313083
49PRKCH0.99684096
50CDK140.99062541
51CDK120.97967110
52PASK0.97916270
53CAMKK10.96926598
54PRKD30.95841016
55CSNK1G20.95683066
56CSNK1G30.95151060
57CDK180.94512441
58CDK150.90865123
59PRKCG0.90174960
60PIM20.90173280
61TNK20.89550893
62MAP2K40.86521441
63MAP3K10.85768108
64CSNK1A1L0.85746221
65CDK11A0.84841300
66SIK30.82554476
67PKN10.81644208
68TAOK20.80661605
69KSR20.77807790
70SGK2230.77410486
71SGK4940.77410486
72DAPK30.76397833
73RPS6KA20.73827233
74FES0.73403205
75MAPK150.70821958
76WNK30.69015474
77RET0.68622760
78PDPK10.67469707
79BCR0.66984780
80MAPK90.65095162
81RIPK40.64258540
82PIK3CG0.63919385
83CAMKK20.63412030
84MAP2K30.63338876
85CCNB10.63322771
86MAP3K60.62586164
87MAP3K100.60069662
88PDK10.58450733
89CAMK1G0.58416481
90CAMK10.58087152
91ALK0.56996007
92ICK0.55712892
93MAP2K20.55543205
94RAF10.54114759
95PRKCI0.53973384
96PNCK0.53407421
97WNK40.52990403
98BRAF0.52663285
99CDK30.52449715
100PRKCZ0.51462701
101CAMK2G0.51134938
102PAK10.50901671
103MTOR0.50282662
104CAMK2B0.49629931
105HIPK20.48663471
106IRAK30.48625358
107PLK20.48161448
108SIK10.48159212
109CSNK1E0.47783432
110MAP2K60.46772456
111CAMK2A0.46210762
112GRK50.45935979
113CAMK1D0.45870236
114LMTK20.45388942
115ACVR1B0.44677799
116PAK30.44672039
117SGK30.44130110
118CSNK1G10.44071063
119STK110.41941058
120* CDK20.41747871
121TGFBR10.40129698
122CDC42BPA0.39229197
123PRKCE0.38924281
124* MAPK80.38753779
125MAP3K20.38263386
126SCYL20.38191236
127RPS6KA30.38101209
128PRKD20.38007931
129IRAK20.37936697
130GRK10.37820170
131* GSK3B0.37755245
132CDC70.37639480
133BRSK10.37301371
134ERBB20.37059626
135TYRO30.35787518
136ADRBK20.34127016
137CLK10.33177696
138AURKA0.31537557
139CAMK40.31225944
140NEK60.31219862
141VRK10.31063303
142STK380.30623410
143MAPK100.29162353
144MAPK40.28528761
145MUSK0.27984276

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.02969772
2Synaptic vesicle cycle_Homo sapiens_hsa047212.75428610
3Morphine addiction_Homo sapiens_hsa050322.39072540
4GABAergic synapse_Homo sapiens_hsa047272.38069286
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.38062677
6Circadian entrainment_Homo sapiens_hsa047132.36382987
7Glutamatergic synapse_Homo sapiens_hsa047242.24046124
8Vitamin B6 metabolism_Homo sapiens_hsa007502.21592143
9Insulin secretion_Homo sapiens_hsa049112.16583651
10Dopaminergic synapse_Homo sapiens_hsa047282.06201028
11Olfactory transduction_Homo sapiens_hsa047402.05760256
12Cholinergic synapse_Homo sapiens_hsa047252.04113675
13Long-term potentiation_Homo sapiens_hsa047201.93377273
14Cocaine addiction_Homo sapiens_hsa050301.89057599
15Serotonergic synapse_Homo sapiens_hsa047261.86733298
16Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.86334858
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.85536436
18Sulfur relay system_Homo sapiens_hsa041221.84159431
19Amphetamine addiction_Homo sapiens_hsa050311.83803116
20Axon guidance_Homo sapiens_hsa043601.72471305
21Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.70334736
22Taste transduction_Homo sapiens_hsa047421.68303304
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.58030732
24Long-term depression_Homo sapiens_hsa047301.55860355
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.54961251
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54690504
27Gap junction_Homo sapiens_hsa045401.51004882
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.48092240
29Estrogen signaling pathway_Homo sapiens_hsa049151.37402240
30Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.34922821
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.34022453
32Pancreatic secretion_Homo sapiens_hsa049721.33733103
33Endometrial cancer_Homo sapiens_hsa052131.32898547
34Pentose phosphate pathway_Homo sapiens_hsa000301.32042619
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.30894796
36DNA replication_Homo sapiens_hsa030301.29705153
37Oxytocin signaling pathway_Homo sapiens_hsa049211.28815007
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27279806
39Salivary secretion_Homo sapiens_hsa049701.26432710
40Type II diabetes mellitus_Homo sapiens_hsa049301.26114859
41Colorectal cancer_Homo sapiens_hsa052101.23590628
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.22685630
43Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.21487599
44ErbB signaling pathway_Homo sapiens_hsa040121.19740189
45Melanogenesis_Homo sapiens_hsa049161.17942910
46Gastric acid secretion_Homo sapiens_hsa049711.15062284
47Ribosome_Homo sapiens_hsa030101.14025416
48SNARE interactions in vesicular transport_Homo sapiens_hsa041301.13713466
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.12848008
50Base excision repair_Homo sapiens_hsa034101.12590466
51Vibrio cholerae infection_Homo sapiens_hsa051101.10401039
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.10154893
53Biosynthesis of amino acids_Homo sapiens_hsa012301.09916717
54Glioma_Homo sapiens_hsa052141.08694539
55GnRH signaling pathway_Homo sapiens_hsa049121.04007083
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99977583
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.98509760
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97873243
59Calcium signaling pathway_Homo sapiens_hsa040200.97114464
60Protein export_Homo sapiens_hsa030600.96754085
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96528186
62Alcoholism_Homo sapiens_hsa050340.93893488
63Renin secretion_Homo sapiens_hsa049240.91550628
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91257231
65Oocyte meiosis_Homo sapiens_hsa041140.88755873
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86872937
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.84939902
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83120761
69Inositol phosphate metabolism_Homo sapiens_hsa005620.82815033
70Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.80966778
71Choline metabolism in cancer_Homo sapiens_hsa052310.79974705
72Wnt signaling pathway_Homo sapiens_hsa043100.79843627
73Phototransduction_Homo sapiens_hsa047440.79198938
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.79137985
75cAMP signaling pathway_Homo sapiens_hsa040240.77980916
76Renal cell carcinoma_Homo sapiens_hsa052110.76648497
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74054455
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71440394
79N-Glycan biosynthesis_Homo sapiens_hsa005100.70490665
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69568821
81mTOR signaling pathway_Homo sapiens_hsa041500.69067492
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.67733258
83Carbon metabolism_Homo sapiens_hsa012000.67530754
84VEGF signaling pathway_Homo sapiens_hsa043700.67452223
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61558851
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60862373
87Thyroid hormone synthesis_Homo sapiens_hsa049180.60458645
88Non-small cell lung cancer_Homo sapiens_hsa052230.58114259
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57626731
90Pyrimidine metabolism_Homo sapiens_hsa002400.56257950
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55540261
92Glucagon signaling pathway_Homo sapiens_hsa049220.55342821
93Thyroid cancer_Homo sapiens_hsa052160.54487765
94Collecting duct acid secretion_Homo sapiens_hsa049660.54430163
95Insulin signaling pathway_Homo sapiens_hsa049100.54272522
96Prion diseases_Homo sapiens_hsa050200.53920709
97Cardiac muscle contraction_Homo sapiens_hsa042600.53417079
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53387712
99AMPK signaling pathway_Homo sapiens_hsa041520.53038058
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.53028973
101Alzheimers disease_Homo sapiens_hsa050100.52998710
102Ras signaling pathway_Homo sapiens_hsa040140.51785764
103Steroid biosynthesis_Homo sapiens_hsa001000.50273965
104Prolactin signaling pathway_Homo sapiens_hsa049170.50263895
105Basal cell carcinoma_Homo sapiens_hsa052170.47344961
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46977834
107MAPK signaling pathway_Homo sapiens_hsa040100.46688595
108Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46255481
109Fatty acid elongation_Homo sapiens_hsa000620.45398263
110Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45003581
111mRNA surveillance pathway_Homo sapiens_hsa030150.44579461
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44552354
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.44199634
114Hedgehog signaling pathway_Homo sapiens_hsa043400.43353718
115Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42988629
116Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42319379
117Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.41723670
118Rap1 signaling pathway_Homo sapiens_hsa040150.41554371
119Chronic myeloid leukemia_Homo sapiens_hsa052200.39899200
120Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.38402914
121Endocytosis_Homo sapiens_hsa041440.37417810
122Arginine and proline metabolism_Homo sapiens_hsa003300.36677142
123Acute myeloid leukemia_Homo sapiens_hsa052210.36638713
124Notch signaling pathway_Homo sapiens_hsa043300.36377197
125Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35861382
126Mismatch repair_Homo sapiens_hsa034300.35621894
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34970833
128Hippo signaling pathway_Homo sapiens_hsa043900.34954162
129Purine metabolism_Homo sapiens_hsa002300.33723583

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »