DEC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The function of this gene is not known. This gene is located in a region commonly deleted in esophageal squamous cell carcinomas. Gene expression is reduced or absent in these carcinomas and thus this is a candidate tumor suppressor gene for esophageal squamous cell carcinomas. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.37973212
2neural tube formation (GO:0001841)4.25256666
3indolalkylamine metabolic process (GO:0006586)4.21711971
4auditory receptor cell differentiation (GO:0042491)4.16171071
5detection of light stimulus involved in visual perception (GO:0050908)4.03934246
6detection of light stimulus involved in sensory perception (GO:0050962)4.03934246
7L-fucose catabolic process (GO:0042355)3.98890714
8fucose catabolic process (GO:0019317)3.98890714
9L-fucose metabolic process (GO:0042354)3.98890714
10axon ensheathment in central nervous system (GO:0032291)3.97396677
11central nervous system myelination (GO:0022010)3.97396677
12indolalkylamine catabolic process (GO:0046218)3.89644652
13tryptophan catabolic process (GO:0006569)3.89644652
14indole-containing compound catabolic process (GO:0042436)3.89644652
15cilium or flagellum-dependent cell motility (GO:0001539)3.89611304
16epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.80567842
17behavioral response to nicotine (GO:0035095)3.78372417
18protein K11-linked deubiquitination (GO:0035871)3.73371413
19signal peptide processing (GO:0006465)3.55681464
20positive regulation of developmental pigmentation (GO:0048087)3.54834386
21photoreceptor cell maintenance (GO:0045494)3.50710263
22regulation of hippo signaling (GO:0035330)3.49658692
23piRNA metabolic process (GO:0034587)3.49105649
24photoreceptor cell development (GO:0042461)3.46778800
25DNA double-strand break processing (GO:0000729)3.45848392
26negative regulation of astrocyte differentiation (GO:0048712)3.38608918
27tryptophan metabolic process (GO:0006568)3.37694994
28kynurenine metabolic process (GO:0070189)3.37279301
29eye photoreceptor cell development (GO:0042462)3.36121854
30nephron tubule morphogenesis (GO:0072078)3.22037207
31nephron epithelium morphogenesis (GO:0072088)3.22037207
32neuron fate determination (GO:0048664)3.18624626
33tachykinin receptor signaling pathway (GO:0007217)3.16403597
34reflex (GO:0060004)3.16371227
35auditory receptor cell stereocilium organization (GO:0060088)3.15946087
36aromatic amino acid family catabolic process (GO:0009074)3.15724846
37detection of mechanical stimulus involved in sensory perception (GO:0050974)3.15608578
38platelet dense granule organization (GO:0060155)3.14395184
39retinal cone cell development (GO:0046549)3.14350736
40gamma-aminobutyric acid transport (GO:0015812)3.14149711
41retinal rod cell development (GO:0046548)3.14030866
42indole-containing compound metabolic process (GO:0042430)3.11473292
43axoneme assembly (GO:0035082)3.10731559
44negative regulation of mast cell activation (GO:0033004)3.08971801
45reciprocal DNA recombination (GO:0035825)3.08647218
46reciprocal meiotic recombination (GO:0007131)3.08647218
47response to pheromone (GO:0019236)3.03633682
48behavioral response to ethanol (GO:0048149)3.01823089
49recombinational repair (GO:0000725)2.95879440
50double-strand break repair via homologous recombination (GO:0000724)2.95518753
51cilium morphogenesis (GO:0060271)2.94049495
52cellular response to sterol (GO:0036315)2.93415523
53DNA methylation involved in gamete generation (GO:0043046)2.92360156
54G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.91105500
55centriole replication (GO:0007099)2.88490427
56mechanoreceptor differentiation (GO:0042490)2.87717817
57inner ear receptor stereocilium organization (GO:0060122)2.83814697
58neuronal action potential propagation (GO:0019227)2.82667753
59establishment of protein localization to Golgi (GO:0072600)2.82070841
60cilium movement (GO:0003341)2.79897695
61regulation of meiosis I (GO:0060631)2.78727893
62amine catabolic process (GO:0009310)2.77310949
63cellular biogenic amine catabolic process (GO:0042402)2.77310949
64negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.76216656
65retina layer formation (GO:0010842)2.76215884
66regulation of heat generation (GO:0031650)2.75853364
67negative regulation of oligodendrocyte differentiation (GO:0048715)2.74658509
68replication fork processing (GO:0031297)2.74144241
69radial glial cell differentiation (GO:0060019)2.73959977
70aromatic amino acid family metabolic process (GO:0009072)2.73893078
71epithelial cilium movement (GO:0003351)2.73838462
72inner ear receptor cell differentiation (GO:0060113)2.71737062
73monoubiquitinated protein deubiquitination (GO:0035520)2.71306228
74cellular ketone body metabolic process (GO:0046950)2.69996995
75cilium organization (GO:0044782)2.69940592
76peptidyl-histidine modification (GO:0018202)2.68642028
77central nervous system neuron axonogenesis (GO:0021955)2.68153814
78intraciliary transport (GO:0042073)2.67676282
79hair cell differentiation (GO:0035315)2.65578643
80protein K63-linked deubiquitination (GO:0070536)2.65577038
81cilium assembly (GO:0042384)2.64829518
82regulation of sarcomere organization (GO:0060297)2.62652010
83renal tubule morphogenesis (GO:0061333)2.61974259
84tyrosine metabolic process (GO:0006570)2.61360546
85negative regulation of DNA-dependent DNA replication (GO:2000104)2.60713781
86protein prenylation (GO:0018342)2.60665902
87prenylation (GO:0097354)2.60665902
88protein K48-linked deubiquitination (GO:0071108)2.60370502
89cornea development in camera-type eye (GO:0061303)2.60166774
90preassembly of GPI anchor in ER membrane (GO:0016254)2.59922683
91regulation of pigment cell differentiation (GO:0050932)2.56695556
92primary amino compound metabolic process (GO:1901160)2.55777727
93protein-cofactor linkage (GO:0018065)2.53965088
94regulation of action potential (GO:0098900)2.53803066
95ketone body metabolic process (GO:1902224)2.50145902
96negative regulation of complement activation (GO:0045916)2.50012890
97central nervous system projection neuron axonogenesis (GO:0021952)2.49443986
98DNA deamination (GO:0045006)2.49303410
99dopamine transport (GO:0015872)2.49076947
100embryonic epithelial tube formation (GO:0001838)2.47493149

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.60665580
2ZNF274_21170338_ChIP-Seq_K562_Hela3.17290424
3VDR_22108803_ChIP-Seq_LS180_Human3.13264013
4EZH2_22144423_ChIP-Seq_EOC_Human3.06820547
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.80052752
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.78930848
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.67701812
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.66631778
9IGF1R_20145208_ChIP-Seq_DFB_Human2.65776631
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.51899056
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.42399684
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.32089592
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.27527737
14TAF15_26573619_Chip-Seq_HEK293_Human2.25281418
15P300_19829295_ChIP-Seq_ESCs_Human2.20697286
16EWS_26573619_Chip-Seq_HEK293_Human2.20267028
17AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.16633838
18FUS_26573619_Chip-Seq_HEK293_Human2.10981637
19CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02933116
20ER_23166858_ChIP-Seq_MCF-7_Human1.94730041
21SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.92205039
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.91369466
23STAT3_23295773_ChIP-Seq_U87_Human1.85698754
24SMAD4_21799915_ChIP-Seq_A2780_Human1.84361106
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.81851895
26UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.80224605
27BCAT_22108803_ChIP-Seq_LS180_Human1.79662630
28PIAS1_25552417_ChIP-Seq_VCAP_Human1.78558639
29AR_21572438_ChIP-Seq_LNCaP_Human1.73610755
30PCGF2_27294783_Chip-Seq_NPCs_Mouse1.69937976
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65121367
32CBP_20019798_ChIP-Seq_JUKART_Human1.64570632
33IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.64570632
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.63892993
35SUZ12_27294783_Chip-Seq_NPCs_Mouse1.63676383
36EZH2_27294783_Chip-Seq_NPCs_Mouse1.63215252
37NR3C1_21868756_ChIP-Seq_MCF10A_Human1.61415528
38TCF4_23295773_ChIP-Seq_U87_Human1.59932488
39SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.55551469
40TOP2B_26459242_ChIP-Seq_MCF-7_Human1.55323926
41SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54124113
42AR_25329375_ChIP-Seq_VCAP_Human1.52815359
43NFE2_27457419_Chip-Seq_LIVER_Mouse1.52540238
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.49051349
45MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.48465864
46OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47671559
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.45796315
48PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.45004098
49TCF4_22108803_ChIP-Seq_LS180_Human1.44979833
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35341710
51TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35113388
52MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34683637
53CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.34589359
54RUNX2_22187159_ChIP-Seq_PCA_Human1.33891690
55POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33555255
56TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33555255
57EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.33085585
58KLF5_20875108_ChIP-Seq_MESCs_Mouse1.32193208
59NANOG_18555785_Chip-Seq_ESCs_Mouse1.31896581
60EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.30952478
61CRX_20693478_ChIP-Seq_RETINA_Mouse1.30453484
62TP53_22573176_ChIP-Seq_HFKS_Human1.29382429
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.28925970
64SMAD_19615063_ChIP-ChIP_OVARY_Human1.28432437
65SOX2_19829295_ChIP-Seq_ESCs_Human1.28227490
66NANOG_19829295_ChIP-Seq_ESCs_Human1.28227490
67FLI1_21867929_ChIP-Seq_TH2_Mouse1.24634713
68P53_22387025_ChIP-Seq_ESCs_Mouse1.23127678
69SMAD4_21741376_ChIP-Seq_EPCs_Human1.22598154
70PRDM14_20953172_ChIP-Seq_ESCs_Human1.21621090
71CDX2_22108803_ChIP-Seq_LS180_Human1.21533235
72HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.19755304
73E2F1_18555785_Chip-Seq_ESCs_Mouse1.15831232
74RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15780691
75TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15711338
76OCT4_21477851_ChIP-Seq_ESCs_Mouse1.15316382
77STAT3_18555785_Chip-Seq_ESCs_Mouse1.14321748
78SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.13093441
79IRF1_19129219_ChIP-ChIP_H3396_Human1.10496779
80CMYC_18555785_Chip-Seq_ESCs_Mouse1.08136266
81FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08094076
82P300_18555785_Chip-Seq_ESCs_Mouse1.07980625
83CBX2_27304074_Chip-Seq_ESCs_Mouse1.07767643
84SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06965664
85GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06731840
86ARNT_22903824_ChIP-Seq_MCF-7_Human1.05321695
87KDM2B_26808549_Chip-Seq_REH_Human1.04756886
88CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04743498
89BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.04630081
90TP53_16413492_ChIP-PET_HCT116_Human1.03083774
91SOX2_21211035_ChIP-Seq_LN229_Gbm1.02805864
92TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02616534
93TP53_18474530_ChIP-ChIP_U2OS_Human1.02141578
94REST_21632747_ChIP-Seq_MESCs_Mouse1.01205645
95FOXA1_25329375_ChIP-Seq_VCAP_Human1.00568363
96FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00568363
97FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00451112
98CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99824614
99EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.99444505
100CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99438884

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.04063037
2MP0003195_calcinosis3.10164745
3MP0008877_abnormal_DNA_methylation3.05237411
4MP0000569_abnormal_digit_pigmentation2.81381374
5MP0005551_abnormal_eye_electrophysiolog2.76614201
6MP0003136_yellow_coat_color2.69230286
7MP0008057_abnormal_DNA_replication2.64936422
8MP0000372_irregular_coat_pigmentation2.59642301
9MP0002638_abnormal_pupillary_reflex2.34800143
10MP0001986_abnormal_taste_sensitivity2.31261890
11MP0002102_abnormal_ear_morphology2.27884325
12MP0001501_abnormal_sleep_pattern2.17798516
13MP0002736_abnormal_nociception_after2.00746926
14MP0001968_abnormal_touch/_nociception2.00699706
15MP0009046_muscle_twitch1.94943790
16MP0003880_abnormal_central_pattern1.93036110
17MP0005253_abnormal_eye_physiology1.85791044
18MP0004147_increased_porphyrin_level1.82760258
19MP0003646_muscle_fatigue1.80331393
20MP0006276_abnormal_autonomic_nervous1.79551148
21MP0009745_abnormal_behavioral_response1.76752882
22MP0006054_spinal_hemorrhage1.76346023
23MP0000427_abnormal_hair_cycle1.76080751
24MP0005645_abnormal_hypothalamus_physiol1.73028724
25MP0008872_abnormal_physiological_respon1.72725473
26MP0006072_abnormal_retinal_apoptosis1.70949484
27MP0005174_abnormal_tail_pigmentation1.61728675
28MP0005646_abnormal_pituitary_gland1.61198504
29MP0001486_abnormal_startle_reflex1.60532727
30MP0000015_abnormal_ear_pigmentation1.57580218
31MP0005171_absent_coat_pigmentation1.55246154
32MP0002938_white_spotting1.52538907
33MP0002095_abnormal_skin_pigmentation1.51065924
34MP0004043_abnormal_pH_regulation1.49794401
35MP0005075_abnormal_melanosome_morpholog1.49511468
36MP0009697_abnormal_copulation1.46085698
37MP0002138_abnormal_hepatobiliary_system1.45236921
38MP0001485_abnormal_pinna_reflex1.37982830
39MP0000631_abnormal_neuroendocrine_gland1.37003091
40MP0000371_diluted_coat_color1.34802511
41MP0001984_abnormal_olfaction1.34496745
42MP0003950_abnormal_plasma_membrane1.29263933
43MP0002572_abnormal_emotion/affect_behav1.28607252
44MP0002272_abnormal_nervous_system1.24014111
45MP0002735_abnormal_chemical_nociception1.22805613
46MP0003787_abnormal_imprinting1.22445822
47MP0004142_abnormal_muscle_tone1.20287140
48MP0004924_abnormal_behavior1.20221797
49MP0005386_behavior/neurological_phenoty1.20221797
50MP0004215_abnormal_myocardial_fiber1.20132750
51MP0005195_abnormal_posterior_eye1.20112520
52MP0000383_abnormal_hair_follicle1.19543140
53MP0002876_abnormal_thyroid_physiology1.18795392
54MP0003718_maternal_effect1.13753541
55MP0001764_abnormal_homeostasis1.11910894
56MP0001970_abnormal_pain_threshold1.09862923
57MP0003878_abnormal_ear_physiology1.09253339
58MP0005377_hearing/vestibular/ear_phenot1.09253339
59MP0006292_abnormal_olfactory_placode1.06917322
60MP0002557_abnormal_social/conspecific_i1.04112163
61MP0002064_seizures1.03202550
62MP0002067_abnormal_sensory_capabilities1.02256873
63MP0000778_abnormal_nervous_system1.01428017
64MP0001324_abnormal_eye_pigmentation1.00984530
65MP0005084_abnormal_gallbladder_morpholo0.99970501
66MP0003635_abnormal_synaptic_transmissio0.97109699
67MP0000230_abnormal_systemic_arterial0.96568578
68MP0003698_abnormal_male_reproductive0.95925409
69MP0004885_abnormal_endolymph0.95541916
70MP0002733_abnormal_thermal_nociception0.95178442
71MP0000026_abnormal_inner_ear0.91489762
72MP0002752_abnormal_somatic_nervous0.90898854
73MP0002234_abnormal_pharynx_morphology0.90614461
74MP0002090_abnormal_vision0.90362948
75MP0002160_abnormal_reproductive_system0.89659057
76MP0001529_abnormal_vocalization0.87753224
77MP0005379_endocrine/exocrine_gland_phen0.86473833
78MP0005410_abnormal_fertilization0.85544174
79MP0002063_abnormal_learning/memory/cond0.84971597
80MP0005167_abnormal_blood-brain_barrier0.84040563
81MP0002184_abnormal_innervation0.83959547
82MP0002229_neurodegeneration0.83240137
83MP0002168_other_aberrant_phenotype0.82658730
84MP0003567_abnormal_fetal_cardiomyocyte0.82556584
85MP0004381_abnormal_hair_follicle0.82391603
86MP0002210_abnormal_sex_determination0.81923361
87MP0005395_other_phenotype0.80920981
88MP0003045_fibrosis0.80305640
89MP0000653_abnormal_sex_gland0.80293172
90MP0003137_abnormal_impulse_conducting0.79822712
91MP0008058_abnormal_DNA_repair0.79170893
92MP0001929_abnormal_gametogenesis0.78832919
93MP0002928_abnormal_bile_duct0.78441827
94MP0002653_abnormal_ependyma_morphology0.77079121
95MP0004085_abnormal_heartbeat0.76292840
96MP0004145_abnormal_muscle_electrophysio0.76246615
97MP0005389_reproductive_system_phenotype0.76201313
98MP0001963_abnormal_hearing_physiology0.75050626
99MP0003890_abnormal_embryonic-extraembry0.74533102
100MP0010386_abnormal_urinary_bladder0.74289250

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.95457514
2Pancreatic fibrosis (HP:0100732)4.49543582
3True hermaphroditism (HP:0010459)4.28097356
4Congenital stationary night blindness (HP:0007642)3.87356349
5Attenuation of retinal blood vessels (HP:0007843)3.79294582
6Abnormality of midbrain morphology (HP:0002418)3.63804558
7Molar tooth sign on MRI (HP:0002419)3.63804558
8Nephronophthisis (HP:0000090)3.62445211
9Hyperventilation (HP:0002883)3.59388171
10Abnormality of the renal medulla (HP:0100957)3.32577246
11Cystic liver disease (HP:0006706)3.27981476
12Gaze-evoked nystagmus (HP:0000640)3.27804268
13Abnormality of the renal cortex (HP:0011035)3.23495960
14Chronic hepatic failure (HP:0100626)3.09005841
15Abolished electroretinogram (ERG) (HP:0000550)2.94789202
16Genetic anticipation (HP:0003743)2.94711632
17Medial flaring of the eyebrow (HP:0010747)2.93110213
18Progressive cerebellar ataxia (HP:0002073)2.85949299
19Aplasia/Hypoplasia of the tongue (HP:0010295)2.72085653
20Keratoconus (HP:0000563)2.70478050
21Increased corneal curvature (HP:0100692)2.70478050
22Aplasia/Hypoplasia of the tibia (HP:0005772)2.68734233
23Abnormal rod and cone electroretinograms (HP:0008323)2.63905330
24Tubular atrophy (HP:0000092)2.59069774
25Congenital sensorineural hearing impairment (HP:0008527)2.51665736
26Absent speech (HP:0001344)2.51222029
27Abnormal ciliary motility (HP:0012262)2.49446230
28Congenital hepatic fibrosis (HP:0002612)2.44404188
29Febrile seizures (HP:0002373)2.42862215
30Sclerocornea (HP:0000647)2.40727001
31Bony spicule pigmentary retinopathy (HP:0007737)2.39882432
32Aplasia/Hypoplasia of the fovea (HP:0008060)2.35182838
33Hypoplasia of the fovea (HP:0007750)2.35182838
34Protruding tongue (HP:0010808)2.32287423
35Pendular nystagmus (HP:0012043)2.32006545
36Broad-based gait (HP:0002136)2.31014782
37Postaxial foot polydactyly (HP:0001830)2.30569301
38Absent rod-and cone-mediated responses on ERG (HP:0007688)2.30530950
39Optic nerve hypoplasia (HP:0000609)2.29594558
40Abnormality of alanine metabolism (HP:0010916)2.28264655
41Hyperalaninemia (HP:0003348)2.28264655
42Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.28264655
43Renal cortical cysts (HP:0000803)2.27917404
44Progressive inability to walk (HP:0002505)2.27752285
45Inability to walk (HP:0002540)2.25455360
46Furrowed tongue (HP:0000221)2.25047752
47Type II lissencephaly (HP:0007260)2.22102436
48Fair hair (HP:0002286)2.20542709
49Albinism (HP:0001022)2.19136156
50Small hand (HP:0200055)2.17876090
51Abnormal drinking behavior (HP:0030082)2.17672722
52Polydipsia (HP:0001959)2.17672722
53Decreased central vision (HP:0007663)2.17629346
54Abnormality of macular pigmentation (HP:0008002)2.12246737
55Dynein arm defect of respiratory motile cilia (HP:0012255)2.11109210
56Absent/shortened dynein arms (HP:0200106)2.11109210
57Chorioretinal atrophy (HP:0000533)2.10247609
58Abnormal respiratory motile cilium morphology (HP:0005938)2.09164356
59Abnormal respiratory epithelium morphology (HP:0012253)2.09164356
60Gait imbalance (HP:0002141)2.08489211
61Genital tract atresia (HP:0001827)2.08258401
62Widely spaced teeth (HP:0000687)2.08165102
63Aplasia/Hypoplasia of the uvula (HP:0010293)2.07306336
64Anencephaly (HP:0002323)2.07047045
65Congenital primary aphakia (HP:0007707)2.06953796
66Stomach cancer (HP:0012126)2.05642944
67Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.04269382
68Intestinal atresia (HP:0011100)2.00860957
69Focal seizures (HP:0007359)2.00806291
70Lissencephaly (HP:0001339)1.97890620
71Decreased electroretinogram (ERG) amplitude (HP:0000654)1.97831893
72Tubulointerstitial nephritis (HP:0001970)1.95592511
73Abnormality of the fovea (HP:0000493)1.95560713
74Astigmatism (HP:0000483)1.94549442
75Abnormal respiratory motile cilium physiology (HP:0012261)1.94365799
76Vaginal atresia (HP:0000148)1.93894500
77Central scotoma (HP:0000603)1.93675363
78Hemiparesis (HP:0001269)1.93205908
79Tubulointerstitial abnormality (HP:0001969)1.92741910
80Nephrogenic diabetes insipidus (HP:0009806)1.92083904
81Enlarged kidneys (HP:0000105)1.91955843
82Preaxial hand polydactyly (HP:0001177)1.89921297
83Postaxial hand polydactyly (HP:0001162)1.89358337
84Methylmalonic aciduria (HP:0012120)1.89068497
85Constricted visual fields (HP:0001133)1.87555097
86Male pseudohermaphroditism (HP:0000037)1.84258820
87Dandy-Walker malformation (HP:0001305)1.82701468
88Focal motor seizures (HP:0011153)1.80495518
89Sloping forehead (HP:0000340)1.80433981
90Cerebellar dysplasia (HP:0007033)1.80287426
91Short chin (HP:0000331)1.80140882
92Atonic seizures (HP:0010819)1.76935050
93Methylmalonic acidemia (HP:0002912)1.73373966
94Thyroid-stimulating hormone excess (HP:0002925)1.73031506
95Short foot (HP:0001773)1.71667263
96Abnormality of the labia minora (HP:0012880)1.71396003
97Abnormality of chromosome stability (HP:0003220)1.70869006
98Decreased circulating renin level (HP:0003351)1.69994582
99Polyuria (HP:0000103)1.69646998
100Generalized hypopigmentation of hair (HP:0011358)1.69528259

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.54443986
2BMPR1B3.10812205
3ACVR1B3.10228924
4MAP4K22.30772514
5NUAK12.29146263
6WNK32.26758087
7BCR2.18219642
8ADRBK22.17046535
9TRIM282.10108832
10ZAK2.00026325
11CASK1.98761482
12TAOK31.94067667
13MST41.89953130
14MAPK131.87856200
15GRK11.83799106
16INSRR1.75741250
17TNIK1.68633434
18STK391.67511789
19EPHA31.64606121
20PINK11.64204530
21MKNK21.53750055
22MAP3K41.52023499
23STK31.41608674
24EIF2AK31.35612199
25WNK41.29896166
26OXSR11.26663741
27EPHA41.25016272
28PLK21.24843102
29STK38L1.22363148
30NTRK21.19065712
31ADRBK11.08645714
32ERBB31.08616481
33TGFBR11.07295117
34AKT31.06906690
35MUSK1.05840732
36NTRK31.04427533
37PRKCE1.03448400
38LATS11.00844035
39PIK3CG0.98826059
40BRSK20.95715645
41TXK0.94182787
42FER0.91264717
43PTK2B0.90723899
44STK110.88816255
45PAK30.83946805
46WEE10.83332047
47MARK10.83066570
48PRKCG0.77750545
49PLK40.77469306
50NLK0.71411339
51TEC0.70992929
52PNCK0.70022503
53DAPK20.68845569
54PLK30.66830940
55CAMKK20.65613669
56SIK30.65068393
57DYRK20.64479585
58MKNK10.62734139
59PKN10.58492958
60FGFR20.57979275
61VRK10.57418291
62CAMK2A0.57324177
63TIE10.55255027
64MAP2K70.54236265
65TLK10.52404796
66CCNB10.51955732
67SGK20.51390954
68PRKCQ0.48739643
69KIT0.47681443
70PDK20.47309017
71CSNK1G10.46473712
72TNK20.46234106
73MAP3K70.44105173
74IRAK10.42201890
75OBSCN0.37882373
76MELK0.37697333
77NEK20.37622891
78CSNK1G20.37569544
79PRKAA20.37066664
80ATR0.35326324
81PRKACA0.35001493
82ATM0.33090177
83GRK50.31570660
84CDK80.31092032
85PLK10.30869624
86CSNK1A1L0.30256590
87CSNK1A10.30068759
88ERBB20.30068515
89EIF2AK20.29816803
90CSNK1G30.29796482
91MAPKAPK30.29251944
92IGF1R0.28855617
93CAMK2D0.27824394
94PIK3CA0.27694000
95MARK30.27647790
96IKBKB0.26320209
97PRKG10.26116044
98ABL10.25376395
99STK380.25271954
100CSNK1D0.24638026

Predicted pathways (KEGG)

RankGene SetZ-score
1Butanoate metabolism_Homo sapiens_hsa006502.79476110
2Phototransduction_Homo sapiens_hsa047442.71605253
3Homologous recombination_Homo sapiens_hsa034402.65999284
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.54629411
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.53152332
6Nitrogen metabolism_Homo sapiens_hsa009102.19442485
7Nicotine addiction_Homo sapiens_hsa050332.17213209
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.17137522
9Linoleic acid metabolism_Homo sapiens_hsa005912.07541752
10Tryptophan metabolism_Homo sapiens_hsa003802.06231629
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.04796117
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.02824694
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.01544917
14Fanconi anemia pathway_Homo sapiens_hsa034601.95121424
15Propanoate metabolism_Homo sapiens_hsa006401.92234689
16Primary bile acid biosynthesis_Homo sapiens_hsa001201.89222605
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.84418880
18ABC transporters_Homo sapiens_hsa020101.72631271
19Basal transcription factors_Homo sapiens_hsa030221.71058967
20Taste transduction_Homo sapiens_hsa047421.69794027
21Selenocompound metabolism_Homo sapiens_hsa004501.69246561
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.65482978
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.65317782
24Olfactory transduction_Homo sapiens_hsa047401.62727208
25Morphine addiction_Homo sapiens_hsa050321.50560944
26Ether lipid metabolism_Homo sapiens_hsa005651.44980814
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.44523917
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.43610988
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.42732720
30RNA degradation_Homo sapiens_hsa030181.38217932
31Circadian entrainment_Homo sapiens_hsa047131.36627248
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.31839229
33Chemical carcinogenesis_Homo sapiens_hsa052041.25951350
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.25316018
35Protein export_Homo sapiens_hsa030601.23541143
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.23510906
37Salivary secretion_Homo sapiens_hsa049701.20857642
38Glutamatergic synapse_Homo sapiens_hsa047241.20681580
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.20090344
40GABAergic synapse_Homo sapiens_hsa047271.19693273
41Non-homologous end-joining_Homo sapiens_hsa034501.18100547
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.18053794
43Serotonergic synapse_Homo sapiens_hsa047261.15004415
44Caffeine metabolism_Homo sapiens_hsa002321.14471012
45Retinol metabolism_Homo sapiens_hsa008301.09295499
46beta-Alanine metabolism_Homo sapiens_hsa004101.07248966
47Regulation of autophagy_Homo sapiens_hsa041401.04895903
48Insulin secretion_Homo sapiens_hsa049111.03552525
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.01474289
50Glycerolipid metabolism_Homo sapiens_hsa005611.00297124
51Dorso-ventral axis formation_Homo sapiens_hsa043200.98801732
52Peroxisome_Homo sapiens_hsa041460.96563880
53Calcium signaling pathway_Homo sapiens_hsa040200.92667106
54Ovarian steroidogenesis_Homo sapiens_hsa049130.87595214
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87198182
56Steroid biosynthesis_Homo sapiens_hsa001000.87191530
57Histidine metabolism_Homo sapiens_hsa003400.81667808
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81214241
59Circadian rhythm_Homo sapiens_hsa047100.77720829
60Fatty acid biosynthesis_Homo sapiens_hsa000610.77420722
61Lysine degradation_Homo sapiens_hsa003100.73833781
62Fatty acid degradation_Homo sapiens_hsa000710.67621874
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.67499733
64Long-term depression_Homo sapiens_hsa047300.66411935
65Sulfur relay system_Homo sapiens_hsa041220.65881925
66Arachidonic acid metabolism_Homo sapiens_hsa005900.65552132
67RNA polymerase_Homo sapiens_hsa030200.65429360
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65396378
69cAMP signaling pathway_Homo sapiens_hsa040240.58081078
70Gastric acid secretion_Homo sapiens_hsa049710.57480790
71One carbon pool by folate_Homo sapiens_hsa006700.56465649
72Intestinal immune network for IgA production_Homo sapiens_hsa046720.55068739
73Cholinergic synapse_Homo sapiens_hsa047250.54910086
74Hedgehog signaling pathway_Homo sapiens_hsa043400.52483423
75Sphingolipid metabolism_Homo sapiens_hsa006000.51973894
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.50780381
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.49624609
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48954231
79Fatty acid metabolism_Homo sapiens_hsa012120.48134776
80Dopaminergic synapse_Homo sapiens_hsa047280.47135867
81Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.45572469
82Renin secretion_Homo sapiens_hsa049240.44795447
83Metabolic pathways_Homo sapiens_hsa011000.44266740
84Cocaine addiction_Homo sapiens_hsa050300.40760994
85Fat digestion and absorption_Homo sapiens_hsa049750.40165363
86Purine metabolism_Homo sapiens_hsa002300.38791526
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38639087
88Oxytocin signaling pathway_Homo sapiens_hsa049210.36668822
89Pancreatic secretion_Homo sapiens_hsa049720.36396929
90Mineral absorption_Homo sapiens_hsa049780.35990762
91Axon guidance_Homo sapiens_hsa043600.35781840
92Tyrosine metabolism_Homo sapiens_hsa003500.31680792
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.30422407
94Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.29135176
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29034547
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.28784576
97Collecting duct acid secretion_Homo sapiens_hsa049660.28058698
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26878567
99African trypanosomiasis_Homo sapiens_hsa051430.25765649
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.25323065

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