DECR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an accessory enzyme which participates in the beta-oxidation and metabolism of unsaturated fatty enoyl-CoA esters. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.93896762
2L-phenylalanine catabolic process (GO:0006559)5.93896762
3L-phenylalanine metabolic process (GO:0006558)5.90123999
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.90123999
5lysine catabolic process (GO:0006554)5.52434938
6lysine metabolic process (GO:0006553)5.52434938
7aromatic amino acid family catabolic process (GO:0009074)5.29733376
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.29124442
9glyoxylate metabolic process (GO:0046487)5.28822450
10alpha-linolenic acid metabolic process (GO:0036109)5.26975829
11* fatty acid beta-oxidation (GO:0006635)5.17246503
12fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.07334414
13regulation of sequestering of triglyceride (GO:0010889)4.99474798
14regulation of triglyceride catabolic process (GO:0010896)4.90492948
15kynurenine metabolic process (GO:0070189)4.82536198
16amino-acid betaine metabolic process (GO:0006577)4.82502326
17* fatty acid oxidation (GO:0019395)4.76696617
18indolalkylamine catabolic process (GO:0046218)4.75821958
19tryptophan catabolic process (GO:0006569)4.75821958
20indole-containing compound catabolic process (GO:0042436)4.75821958
21fatty acid transmembrane transport (GO:1902001)4.74227618
22cysteine metabolic process (GO:0006534)4.71263762
23* lipid oxidation (GO:0034440)4.68400968
24* fatty acid catabolic process (GO:0009062)4.66427464
25bile acid biosynthetic process (GO:0006699)4.64936325
26exogenous drug catabolic process (GO:0042738)4.61941278
27sulfur amino acid catabolic process (GO:0000098)4.61329098
28short-chain fatty acid metabolic process (GO:0046459)4.59720553
29acetyl-CoA metabolic process (GO:0006084)4.59208567
30valine metabolic process (GO:0006573)4.57833181
31carnitine shuttle (GO:0006853)4.54591393
32cellular ketone body metabolic process (GO:0046950)4.52316905
33xenobiotic catabolic process (GO:0042178)4.52013745
34tryptophan metabolic process (GO:0006568)4.48923129
35branched-chain amino acid catabolic process (GO:0009083)4.48610606
362-oxoglutarate metabolic process (GO:0006103)4.47666550
37positive regulation of fatty acid beta-oxidation (GO:0032000)4.40923476
38* monocarboxylic acid catabolic process (GO:0072329)4.33969673
39carnitine metabolic process (GO:0009437)4.32963990
40homocysteine metabolic process (GO:0050667)4.25667959
41serine family amino acid catabolic process (GO:0009071)4.23703766
42urea cycle (GO:0000050)4.23488542
43urea metabolic process (GO:0019627)4.23488542
44positive regulation of fatty acid oxidation (GO:0046321)4.21611115
45branched-chain amino acid metabolic process (GO:0009081)4.18662157
46mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.16756872
47aspartate family amino acid catabolic process (GO:0009068)4.15605540
48acylglycerol homeostasis (GO:0055090)4.13906451
49triglyceride homeostasis (GO:0070328)4.13906451
50complement activation, alternative pathway (GO:0006957)4.11192848
51tricarboxylic acid cycle (GO:0006099)4.10030816
52high-density lipoprotein particle remodeling (GO:0034375)4.08190823
53alpha-amino acid catabolic process (GO:1901606)4.07266493
54biotin metabolic process (GO:0006768)4.02561999
55regulation of fatty acid oxidation (GO:0046320)4.01926489
56ethanol oxidation (GO:0006069)4.01901577
57negative regulation of fibrinolysis (GO:0051918)3.96412390
58protein carboxylation (GO:0018214)3.96222190
59peptidyl-glutamic acid carboxylation (GO:0017187)3.96222190
60bile acid metabolic process (GO:0008206)3.95521143
61nitrogen cycle metabolic process (GO:0071941)3.95128574
62plasma lipoprotein particle clearance (GO:0034381)3.93406515
63aromatic amino acid family metabolic process (GO:0009072)3.93346841
64ketone body metabolic process (GO:1902224)3.91787779
65positive regulation of lipid catabolic process (GO:0050996)3.90320856
66* organic acid catabolic process (GO:0016054)3.89671479
67* carboxylic acid catabolic process (GO:0046395)3.89671479
68cellular amino acid catabolic process (GO:0009063)3.89367037
69regulation of protein activation cascade (GO:2000257)3.88838095
70glucuronate metabolic process (GO:0019585)3.86710018
71uronic acid metabolic process (GO:0006063)3.86710018
72coenzyme catabolic process (GO:0009109)3.81472019
73omega-hydroxylase P450 pathway (GO:0097267)3.76877743
74regulation of fibrinolysis (GO:0051917)3.75707118
75phenylpropanoid metabolic process (GO:0009698)3.73305807
76tyrosine metabolic process (GO:0006570)3.72418515
77protein-lipid complex remodeling (GO:0034368)3.72051005
78macromolecular complex remodeling (GO:0034367)3.72051005
79plasma lipoprotein particle remodeling (GO:0034369)3.72051005
80negative regulation of fatty acid biosynthetic process (GO:0045717)3.70815436
81drug metabolic process (GO:0017144)3.67267816
82regulation of complement activation (GO:0030449)3.65839683
83mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.63732957
84carnitine transmembrane transport (GO:1902603)3.63334254
85tricarboxylic acid metabolic process (GO:0072350)3.63172432
86reverse cholesterol transport (GO:0043691)3.62416597
87regulation of fatty acid beta-oxidation (GO:0031998)3.62101819
88respiratory electron transport chain (GO:0022904)3.61863759
89carnitine transport (GO:0015879)3.61727220
90amino-acid betaine transport (GO:0015838)3.61727220
91energy coupled proton transport, down electrochemical gradient (GO:0015985)3.60747757
92ATP synthesis coupled proton transport (GO:0015986)3.60747757
93regulation of cholesterol esterification (GO:0010872)3.58603722
94regulation of cholesterol metabolic process (GO:0090181)3.58283831
95negative regulation of lipase activity (GO:0060192)3.52230028
96electron transport chain (GO:0022900)3.52204417
97phospholipid homeostasis (GO:0055091)3.51137016
98cellular glucuronidation (GO:0052695)3.50702219
99NADH metabolic process (GO:0006734)3.50071807
100heart process (GO:0003015)3.49824283
101heart contraction (GO:0060047)3.49824283
102ethanol metabolic process (GO:0006067)3.49442835
103succinate metabolic process (GO:0006105)3.46899800
104cellular modified amino acid catabolic process (GO:0042219)3.45043840
105phospholipid efflux (GO:0033700)3.42815697
106glutamate metabolic process (GO:0006536)3.42639354
107serine family amino acid metabolic process (GO:0009069)3.42343911
108triglyceride catabolic process (GO:0019433)3.42090083
109acyl-CoA metabolic process (GO:0006637)3.41630679
110thioester metabolic process (GO:0035383)3.41630679
111epoxygenase P450 pathway (GO:0019373)3.38837073
112glycine metabolic process (GO:0006544)3.37864226
113drug catabolic process (GO:0042737)3.37132117
114benzene-containing compound metabolic process (GO:0042537)3.37071660
115S-adenosylmethionine metabolic process (GO:0046500)3.35687623
116negative regulation of sterol transport (GO:0032372)3.35449323
117negative regulation of cholesterol transport (GO:0032375)3.35449323
118fat-soluble vitamin biosynthetic process (GO:0042362)3.23408008
119polyketide metabolic process (GO:0030638)3.19098388
120doxorubicin metabolic process (GO:0044598)3.19098388
121daunorubicin metabolic process (GO:0044597)3.19098388
122fibrinolysis (GO:0042730)3.18838262
123blood coagulation, intrinsic pathway (GO:0007597)3.10942091
124arginine metabolic process (GO:0006525)3.06549544
125aldehyde catabolic process (GO:0046185)2.95014451
126oxidative demethylation (GO:0070989)2.94358064
127hormone catabolic process (GO:0042447)2.90059552
128actin-myosin filament sliding (GO:0033275)2.88834908
129muscle filament sliding (GO:0030049)2.88834908
130bile acid and bile salt transport (GO:0015721)2.88167018
131oxaloacetate metabolic process (GO:0006107)2.86488097
132aminoglycoside antibiotic metabolic process (GO:0030647)2.82076416
133negative regulation of protein activation cascade (GO:2000258)2.79256344
134negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.78135462
135oxidative phosphorylation (GO:0006119)2.77706048
136primary alcohol metabolic process (GO:0034308)2.77670810
137arginine catabolic process (GO:0006527)2.76059253
138positive regulation of lipoprotein lipase activity (GO:0051006)2.74878415
139positive regulation of triglyceride lipase activity (GO:0061365)2.74878415
140primary alcohol catabolic process (GO:0034310)2.74404150
141phenol-containing compound catabolic process (GO:0019336)2.73583801
142alkaloid metabolic process (GO:0009820)2.71229953
143response to nitrosative stress (GO:0051409)2.66504282
144xenobiotic metabolic process (GO:0006805)2.66056322
145vitamin biosynthetic process (GO:0009110)2.65978304
146positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.64450059
147peroxisome fission (GO:0016559)2.63744164
148negative regulation of complement activation (GO:0045916)2.62343827
149negative regulation of blood coagulation (GO:0030195)2.60893880
150negative regulation of hemostasis (GO:1900047)2.60893880
151flavonoid metabolic process (GO:0009812)2.55593650

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse8.88463159
2* RXR_22158963_ChIP-Seq_LIVER_Mouse7.22453165
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.35225750
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.69407019
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.36541992
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.46053724
7* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.25974270
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.14809955
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.61989075
10BP1_19119308_ChIP-ChIP_Hs578T_Human3.51929140
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.99709977
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.95398294
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.47471496
14CLOCK_20551151_ChIP-Seq_293T_Human2.42377765
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.23253659
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.12804961
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.11279746
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.10479887
19ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.09601348
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.3378577
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.99087999
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.99021793
23TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.92422556
24GATA1_22025678_ChIP-Seq_K562_Human1.90681385
25SRF_21415370_ChIP-Seq_HL-1_Mouse1.82303516
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.77001198
27VDR_22108803_ChIP-Seq_LS180_Human1.71276385
28FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.66383927
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.54108064
30ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.45613444
31FOXA2_19822575_ChIP-Seq_HepG2_Human1.40832718
32NFE2_27457419_Chip-Seq_LIVER_Mouse1.35631160
33SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30898372
34EZH2_27294783_Chip-Seq_NPCs_Mouse1.29470448
35RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28435278
36PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.28154965
37ELK1_19687146_ChIP-ChIP_HELA_Human1.27144896
38IRF8_27001747_Chip-Seq_BMDM_Mouse1.27119497
39LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.26486870
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.25373367
41ZNF263_19887448_ChIP-Seq_K562_Human1.25249354
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25161775
43HNF4A_19822575_ChIP-Seq_HepG2_Human1.23969167
44IGF1R_20145208_ChIP-Seq_DFB_Human1.21283440
45EST1_17652178_ChIP-ChIP_JURKAT_Human1.21184789
46PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.20908731
47* ER_23166858_ChIP-Seq_MCF-7_Human1.20308939
48PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.16015217
49STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15669431
50CRX_20693478_ChIP-Seq_RETINA_Mouse1.15158025
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15145900
52SALL4_22934838_ChIP-ChIP_CD34+_Human1.14728828
53FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12363688
54TBX20_22328084_ChIP-Seq_HEART_Mouse1.12128537
55TBX20_22080862_ChIP-Seq_HEART_Mouse1.12128537
56ESR1_20079471_ChIP-ChIP_T-47D_Human1.12076610
57GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.11892003
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11703843
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10823362
60SOX2_19829295_ChIP-Seq_ESCs_Human1.09212903
61NANOG_19829295_ChIP-Seq_ESCs_Human1.09212903
62GATA3_26560356_Chip-Seq_TH2_Human1.08923354
63CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.07020966
64CDX2_22108803_ChIP-Seq_LS180_Human1.06276612
65IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.05132206
66HNFA_21074721_ChIP-Seq_CACO-2_Human1.03817748
67HTT_18923047_ChIP-ChIP_STHdh_Human1.03151085
68PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02541620
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01728403
70SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01458035
71CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01399179
72GATA6_21074721_ChIP-Seq_CACO-2_Human0.99987140
73SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99549018
74FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98468833
75FOXA1_25329375_ChIP-Seq_VCAP_Human0.98468833
76SPI1_23547873_ChIP-Seq_NB4_Human0.98398413
77PPAR_26484153_Chip-Seq_NCI-H1993_Human0.98184872
78EP300_21415370_ChIP-Seq_HL-1_Mouse0.97925144
79PHF8_20622853_ChIP-Seq_HELA_Human0.97881739
80STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.97392934
81NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.95271771
82PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95169632
83LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.95134068
84PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.94145230
85CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93911370
86STAT3_18555785_Chip-Seq_ESCs_Mouse0.93630996
87TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.93014400
88BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92959975
89GATA4_25053715_ChIP-Seq_YYC3_Human0.92634695
90SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92609496
91FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.92467404
92SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.91549400
93VDR_23849224_ChIP-Seq_CD4+_Human0.90291410
94TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90046623
95CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.89622753
96NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.89511088
97SMAD_19615063_ChIP-ChIP_OVARY_Human0.88610366
98OCT4_21477851_ChIP-Seq_ESCs_Mouse0.88563524
99RBPJ_21746931_ChIP-Seq_IB4_Human0.86912849
100GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.86709998
101RXRA_24833708_ChIP-Seq_LIVER_Mouse0.86691908
102NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.86464029
103IRF8_22096565_ChIP-ChIP_GC-B_Human0.85431449
104P53_22387025_ChIP-Seq_ESCs_Mouse0.84355876
105EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.83974643
106SMAD1_18555785_Chip-Seq_ESCs_Mouse0.83157216
107FOXH1_21741376_ChIP-Seq_EPCs_Human0.83040790
108CTCF_18555785_Chip-Seq_ESCs_Mouse0.82897600
109SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.82683009
110STAT3_1855785_ChIP-Seq_MESCs_Mouse0.81082899
111* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.79611858
112ESR2_21235772_ChIP-Seq_MCF-7_Human0.78042961
113NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.76567829
114NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.76323433
115NRF2_20460467_ChIP-Seq_MEFs_Mouse0.76323433
116SALL4_18804426_ChIP-ChIP_XEN_Mouse0.75444038
117TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73986336
118AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.72519776
119EGR1_19032775_ChIP-ChIP_M12_Human0.70601415
120AR_20517297_ChIP-Seq_VCAP_Human0.66802226
121CEBPB_22108803_ChIP-Seq_LS180_Human0.66651466
122* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.66304648
123E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.63845050
124TRIM28_21343339_ChIP-Seq_HEK293_Human0.62382309
125Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.61962206
126GATA4_21415370_ChIP-Seq_HL-1_Mouse0.61531779
127ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.60930581
128RAD21_21589869_ChIP-Seq_MESCs_Mouse0.60670947
129BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.59793423
130CDX2_20551321_ChIP-Seq_CACO-2_Human0.59422709
131FOXO3_23340844_ChIP-Seq_DLD1_Human0.59272300
132ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.58040648
133NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.57141029
134GATA2_19941826_ChIP-Seq_K562_Human0.56375217
135BCAT_22108803_ChIP-Seq_LS180_Human0.55911627
136TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.55683503
137GATA2_21666600_ChIP-Seq_HMVEC_Human0.55042468
138RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.54855836
139ERG_20517297_ChIP-Seq_VCAP_Human0.54769433
140CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.54604955
141CBP_21632823_ChIP-Seq_H3396_Human0.53301402
142ESR1_21235772_ChIP-Seq_MCF-7_Human0.53031567
143FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.53017743
144GATA1_19941826_ChIP-Seq_K562_Human0.51917402
145CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.51767987
146PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.50945819
147GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.50915816
148* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.50434181
149* FOXA1_25552417_ChIP-Seq_VCAP_Human0.48985710
150RARA_24833708_ChIP-Seq_LIVER_Mouse0.48748550
151SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.48631387
152* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.48612465
153SOX2_20726797_ChIP-Seq_SW620_Human0.47832452
154* GATA3_24758297_ChIP-Seq_MCF-7_Human0.47660724
155ESET_19884257_ChIP-Seq_ESCs_Mouse0.46445126
156ESR1_15608294_ChIP-ChIP_MCF-7_Human0.45507698
157* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.44761677
158RARB_24833708_ChIP-Seq_LIVER_Mouse0.44496303
159P63_26484246_Chip-Seq_KERATINOCYTES_Human0.44439916
160GATA1_19941827_ChIP-Seq_MEL_Mouse0.44399263
161CSB_26484114_Chip-Seq_FIBROBLAST_Human0.44267567
162TAF2_19829295_ChIP-Seq_ESCs_Human0.44013392
163CDX2_19796622_ChIP-Seq_MESCs_Mouse0.43734274
164GATA6_25053715_ChIP-Seq_YYC3_Human0.43643989
165* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.43349100

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.74944190
2MP0005360_urolithiasis6.18028555
3MP0005085_abnormal_gallbladder_physiolo5.22642657
4MP0005365_abnormal_bile_salt5.12772855
5MP0008875_abnormal_xenobiotic_pharmacok3.90396385
6MP0003806_abnormal_nucleotide_metabolis3.46038099
7MP0010329_abnormal_lipoprotein_level3.25600343
8MP0003252_abnormal_bile_duct3.18488629
9MP0005332_abnormal_amino_acid2.86518335
10MP0005670_abnormal_white_adipose2.85108001
11MP0004130_abnormal_muscle_cell2.66103866
12MP0003195_calcinosis2.65927631
13MP0002837_dystrophic_cardiac_calcinosis2.61129850
14MP0009840_abnormal_foam_cell2.39124553
15MP0005083_abnormal_biliary_tract2.30930473
16MP0003646_muscle_fatigue2.21001541
17MP0003191_abnormal_cellular_cholesterol2.18055583
18* MP0002118_abnormal_lipid_homeostasis2.18028409
19MP0005666_abnormal_adipose_tissue2.14445306
20MP0001666_abnormal_nutrient_absorption2.11521256
21MP0006036_abnormal_mitochondrial_physio2.02433823
22* MP0000609_abnormal_liver_physiology1.96267201
23MP0009785_altered_susceptibility_to1.95135373
24MP0005319_abnormal_enzyme/_coenzyme1.84980270
25MP0004019_abnormal_vitamin_homeostasis1.81753914
26MP0005584_abnormal_enzyme/coenzyme_acti1.71725820
27MP0002971_abnormal_brown_adipose1.71614516
28MP0005330_cardiomyopathy1.64351655
29MP0003186_abnormal_redox_activity1.63227579
30MP0002138_abnormal_hepatobiliary_system1.59183469
31MP0004145_abnormal_muscle_electrophysio1.53709840
32MP0004185_abnormal_adipocyte_glucose1.51837457
33MP0001835_abnormal_antigen_presentation1.50258405
34MP0009643_abnormal_urine_homeostasis1.49423594
35MP0005408_hypopigmentation1.46650832
36MP0002132_abnormal_respiratory_system1.46503505
37MP0001764_abnormal_homeostasis1.45454333
38MP0005451_abnormal_body_composition1.38303827
39MP0004084_abnormal_cardiac_muscle1.37302949
40MP0009697_abnormal_copulation1.30692171
41MP0004215_abnormal_myocardial_fiber1.28305944
42MP0003705_abnormal_hypodermis_morpholog1.24624087
43MP0003868_abnormal_feces_composition1.24392744
44MP0005375_adipose_tissue_phenotype1.23757908
45MP0005671_abnormal_response_to1.21993353
46MP0004036_abnormal_muscle_relaxation1.21613196
47MP0008775_abnormal_heart_ventricle1.18767725
48MP0002148_abnormal_hypersensitivity_rea1.18261691
49MP0006082_CNS_inflammation1.16140863
50* MP0005535_abnormal_body_temperature1.13505925
51MP0000751_myopathy1.12105776
52MP0006035_abnormal_mitochondrial_morpho1.12093751
53MP0010368_abnormal_lymphatic_system1.10488404
54MP0005334_abnormal_fat_pad1.09032694
55MP0000372_irregular_coat_pigmentation1.08649051
56MP0005025_abnormal_response_to1.07722213
57MP0000749_muscle_degeneration1.07086843
58MP0003011_delayed_dark_adaptation1.06701326
59* MP0002078_abnormal_glucose_homeostasis1.06625125
60MP0005464_abnormal_platelet_physiology1.02236639
61MP0002419_abnormal_innate_immunity1.02050017
62MP0004087_abnormal_muscle_fiber1.01834547
63MP0001544_abnormal_cardiovascular_syste1.00398687
64MP0005385_cardiovascular_system_phenoty1.00398687
65* MP0000598_abnormal_liver_morphology0.99937506
66MP0001845_abnormal_inflammatory_respons0.98837786
67MP0002166_altered_tumor_susceptibility0.96988410
68MP0003656_abnormal_erythrocyte_physiolo0.96939937
69MP0004043_abnormal_pH_regulation0.96704189
70MP0002972_abnormal_cardiac_muscle0.96455735
71MP0005166_decreased_susceptibility_to0.94437022
72MP0003828_pulmonary_edema0.93913404
73MP0006138_congestive_heart_failure0.93590074
74MP0001790_abnormal_immune_system0.91996355
75MP0005387_immune_system_phenotype0.91996355
76MP0003221_abnormal_cardiomyocyte_apopto0.91738057
77MP0009763_increased_sensitivity_to0.91197225
78MP0001800_abnormal_humoral_immune0.89930384
79MP0005266_abnormal_metabolism0.89743572
80MP0003075_altered_response_to0.89460276
81MP0001661_extended_life_span0.88333130
82MP0009115_abnormal_fat_cell0.88251977
83MP0005636_abnormal_mineral_homeostasis0.88213512
84MP0002127_abnormal_cardiovascular_syste0.87931195
85MP0005620_abnormal_muscle_contractility0.87886251
86MP0002269_muscular_atrophy0.87240268
87MP0001756_abnormal_urination0.86276921
88MP0010630_abnormal_cardiac_muscle0.86107927
89MP0000685_abnormal_immune_system0.85981880
90MP0005000_abnormal_immune_tolerance0.83806866
91MP0009764_decreased_sensitivity_to0.83629058
92MP0005084_abnormal_gallbladder_morpholo0.83267642
93* MP0009642_abnormal_blood_homeostasis0.82590387
94MP0010155_abnormal_intestine_physiology0.80890117
95MP0005647_abnormal_sex_gland0.80781628
96MP0005379_endocrine/exocrine_gland_phen0.80767556
97MP0002970_abnormal_white_adipose0.80634228
98MP0005376_homeostasis/metabolism_phenot0.80129245
99MP0002876_abnormal_thyroid_physiology0.78957567
100MP0008438_abnormal_cutaneous_collagen0.78837907
101MP0003183_abnormal_peptide_metabolism0.78648384
102MP0000230_abnormal_systemic_arterial0.77667827
103MP0004147_increased_porphyrin_level0.77559359
104MP0005448_abnormal_energy_balance0.75924489
105MP0008469_abnormal_protein_level0.74953521
106MP0004883_abnormal_blood_vessel0.74796069
107MP0005058_abnormal_lysosome_morphology0.74512941
108MP0002723_abnormal_immune_serum0.74436815
109MP0005164_abnormal_response_to0.73847382
110MP0002332_abnormal_exercise_endurance0.73829821
111MP0002452_abnormal_antigen_presenting0.73083955
112MP0003950_abnormal_plasma_membrane0.71443895
113MP0003724_increased_susceptibility_to0.69073188
114MP0002254_reproductive_system_inflammat0.66623140
115MP0003137_abnormal_impulse_conducting0.61309285
116MP0000747_muscle_weakness0.59338325
117MP0002136_abnormal_kidney_physiology0.59047241
118MP0000343_altered_response_to0.59018897
119MP0003690_abnormal_glial_cell0.58006136
120MP0004484_altered_response_of0.57960197
121MP0000750_abnormal_muscle_regeneration0.57338105
122MP0000003_abnormal_adipose_tissue0.56230351
123MP0003959_abnormal_lean_body0.55717005
124MP0000013_abnormal_adipose_tissue0.53645562
125MP0005165_increased_susceptibility_to0.52467846
126MP0003953_abnormal_hormone_level0.51256182
127MP0000604_amyloidosis0.51237045
128MP0000759_abnormal_skeletal_muscle0.50226788
129MP0001853_heart_inflammation0.49778973
130MP0002106_abnormal_muscle_physiology0.48668407
131MP0001879_abnormal_lymphatic_vessel0.46805592
132MP0009765_abnormal_xenobiotic_induced0.46379147

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.22771281
2Hypoglycemic coma (HP:0001325)5.19977076
3Hyperglycinuria (HP:0003108)5.07352727
4Intrahepatic cholestasis (HP:0001406)5.01371099
5Abnormality of fatty-acid metabolism (HP:0004359)4.93042680
6Xanthomatosis (HP:0000991)4.92032019
7Hyperammonemia (HP:0001987)4.88643904
8Deep venous thrombosis (HP:0002625)4.81038730
9Ketosis (HP:0001946)4.66696535
10Abnormality of glycine metabolism (HP:0010895)4.64504659
11Abnormality of serine family amino acid metabolism (HP:0010894)4.64504659
12Hyperlipoproteinemia (HP:0010980)4.32331775
13Abnormality of monocarboxylic acid metabolism (HP:0010996)4.29148046
14Hyperglycinemia (HP:0002154)4.28884051
15Hypobetalipoproteinemia (HP:0003563)4.27462565
16Dicarboxylic aciduria (HP:0003215)4.18096152
17Abnormality of dicarboxylic acid metabolism (HP:0010995)4.18096152
18Ketoacidosis (HP:0001993)4.15287883
19Prolonged partial thromboplastin time (HP:0003645)4.08501064
20Abnormality of long-chain fatty-acid metabolism (HP:0010964)4.06403129
21Hypoalphalipoproteinemia (HP:0003233)3.88189329
22Hypolipoproteinemia (HP:0010981)3.84202845
23Myoglobinuria (HP:0002913)3.83151690
24Generalized aminoaciduria (HP:0002909)3.79360896
25Abnormality of glutamine family amino acid metabolism (HP:0010902)3.67220655
26Epidermoid cyst (HP:0200040)3.65563839
27Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.64942984
28Mitochondrial inheritance (HP:0001427)3.64649002
29Complement deficiency (HP:0004431)3.64018457
30Cerebral edema (HP:0002181)3.54358082
31Systemic lupus erythematosus (HP:0002725)3.52719369
32Progressive macrocephaly (HP:0004481)3.52460280
33Hepatic necrosis (HP:0002605)3.29763296
34Metabolic acidosis (HP:0001942)3.24575410
35Rhabdomyolysis (HP:0003201)3.21952506
36Lethargy (HP:0001254)3.21709676
37Proximal tubulopathy (HP:0000114)3.08207255
38Abnormality of sulfur amino acid metabolism (HP:0004339)3.04016578
39Nausea (HP:0002018)3.02471923
40* Abnormality of aspartate family amino acid metabolism (HP:0010899)3.02219272
41Abnormality of methionine metabolism (HP:0010901)3.00315666
42Joint hemorrhage (HP:0005261)2.96485939
43Abnormality of the common coagulation pathway (HP:0010990)2.93605439
44Renal cortical cysts (HP:0000803)2.90374142
45* Abnormality of serum amino acid levels (HP:0003112)2.89983582
46Recurrent gram-negative bacterial infections (HP:0005420)2.80646315
47Acute encephalopathy (HP:0006846)2.78566268
48Hypercholesterolemia (HP:0003124)2.77239189
49Fat malabsorption (HP:0002630)2.73636063
50Vomiting (HP:0002013)2.72130175
51Abnormality of purine metabolism (HP:0004352)2.71381078
52Increased muscle lipid content (HP:0009058)2.69792961
53Delayed CNS myelination (HP:0002188)2.68353915
54Abnormality of the intrinsic pathway (HP:0010989)2.63806513
55Hyperbilirubinemia (HP:0002904)2.62608230
56Skin nodule (HP:0200036)2.62250078
57Abnormality of nucleobase metabolism (HP:0010932)2.53733599
58Abnormality of complement system (HP:0005339)2.53383781
59Renal Fanconi syndrome (HP:0001994)2.48473475
60Gout (HP:0001997)2.48009636
61Abnormality of proline metabolism (HP:0010907)2.47772994
62Hydroxyprolinuria (HP:0003080)2.47772994
63Reduced antithrombin III activity (HP:0001976)2.45720991
64Abnormality of urine glucose concentration (HP:0011016)2.43032816
65Glycosuria (HP:0003076)2.43032816
66Glomerulonephritis (HP:0000099)2.41245749
67Exercise-induced myalgia (HP:0003738)2.39739525
68Respiratory failure (HP:0002878)2.39479046
69Abnormality of glycolysis (HP:0004366)2.38433197
70Increased serum pyruvate (HP:0003542)2.38433197
71Hypoglycemic seizures (HP:0002173)2.38327587
72Palpitations (HP:0001962)2.38029331
73Hyperphosphaturia (HP:0003109)2.37982872
74Lipid accumulation in hepatocytes (HP:0006561)2.37082466
75Increased hepatocellular lipid droplets (HP:0006565)2.34393381
76Decreased activity of mitochondrial respiratory chain (HP:0008972)2.34153171
77Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.34153171
78Dilated cardiomyopathy (HP:0001644)2.32033018
79Lactic acidosis (HP:0003128)2.27087670
80Conjugated hyperbilirubinemia (HP:0002908)2.26961611
81Hepatocellular necrosis (HP:0001404)2.24994430
82Cerebral palsy (HP:0100021)2.24440892
83Myocardial infarction (HP:0001658)2.23864223
843-Methylglutaconic aciduria (HP:0003535)2.23211167
85Abnormal mitochondria in muscle tissue (HP:0008316)2.23095596
86Hyperinsulinemic hypoglycemia (HP:0000825)2.21944599
87Hyperuricemia (HP:0002149)2.21493901
88Increased purine levels (HP:0004368)2.21493901
89Hypertriglyceridemia (HP:0002155)2.21300561
90Bundle branch block (HP:0011710)2.20017067
91Abnormality of pyrimidine metabolism (HP:0004353)2.18438641
92Hepatocellular carcinoma (HP:0001402)2.18150107
93Exercise intolerance (HP:0003546)2.16843962
94Pancreatitis (HP:0001733)2.16724793
95Abnormal cartilage morphology (HP:0002763)2.15129172
96Methylmalonic aciduria (HP:0012120)2.14641308
97Right ventricular cardiomyopathy (HP:0011663)2.14532777
98Cholelithiasis (HP:0001081)2.13754973
99CNS demyelination (HP:0007305)2.11520199
100Abnormal gallbladder morphology (HP:0012437)2.09797671
101Acute necrotizing encephalopathy (HP:0006965)2.09585775
102Sudden death (HP:0001699)2.08669802
103Conjunctival hamartoma (HP:0100780)2.05024612
104Hyperglycemia (HP:0003074)2.04346922
105Ragged-red muscle fibers (HP:0003200)2.03020622
106Ventricular tachycardia (HP:0004756)2.02522051
107Late onset (HP:0003584)2.00547479
108Steatorrhea (HP:0002570)1.99018336
109Exertional dyspnea (HP:0002875)1.98414103
110Asymmetric septal hypertrophy (HP:0001670)1.95443562
111Exercise-induced muscle cramps (HP:0003710)1.95427189
112Increased serum lactate (HP:0002151)1.91821683
113Syncope (HP:0001279)1.91125432
114Type I transferrin isoform profile (HP:0003642)1.90581900
115Increased intramyocellular lipid droplets (HP:0012240)1.90100137
116Sensorimotor neuropathy (HP:0007141)1.89715349
117Nemaline bodies (HP:0003798)1.89573395
118Brushfield spots (HP:0001088)1.89065052
119Vascular calcification (HP:0004934)1.88581871
120Gingival bleeding (HP:0000225)1.88150813
121Muscle fiber inclusion bodies (HP:0100299)1.87720949
122Increased CSF lactate (HP:0002490)1.87582508
123Oligomenorrhea (HP:0000876)1.85845034
124Lipoatrophy (HP:0100578)1.85774438
125Elevated hepatic transaminases (HP:0002910)1.85364580
126Neonatal onset (HP:0003623)1.84959290
127Elevated erythrocyte sedimentation rate (HP:0003565)1.84766085
128Abnormality of renal resorption (HP:0011038)1.84638644
129Respiratory distress (HP:0002098)1.84383955
130Muscle hypertrophy of the lower extremities (HP:0008968)1.83849509
131Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.80622542
132Optic disc pallor (HP:0000543)1.79273345
133Hyporeflexia of lower limbs (HP:0002600)1.78500858
134Ventricular arrhythmia (HP:0004308)1.77681745
135Heart block (HP:0012722)1.77565425
136Spontaneous abortion (HP:0005268)1.74532499
137Abnormal urine phosphate concentration (HP:0012599)1.74132733
138Leukodystrophy (HP:0002415)1.73286182
139Calf muscle hypertrophy (HP:0008981)1.72933094

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.10687692
2PDK33.61326998
3PDK43.61326998
4TRIB33.42167649
5SIK13.10343409
6MAP3K123.04265842
7PKN22.77868004
8TTN2.47723425
9ERN12.43482212
10FGFR42.38122376
11PDK22.30468642
12INSRR2.23384716
13OBSCN2.13210409
14EIF2AK32.07893032
15TIE12.03704575
16MAP4K22.03519764
17LMTK21.86247391
18MYLK1.85109565
19EIF2AK11.83308442
20PINK11.81154343
21FLT31.80024945
22NEK91.78843108
23MST41.75076849
24STK161.69696733
25NME21.59783746
26PRKAA21.58168904
27TXK1.55229118
28CAMK1D1.54732633
29STK38L1.54446796
30RIPK41.53032849
31MST1R1.46640541
32ERBB31.46274729
33MAP2K31.46169744
34PHKG21.44716346
35PHKG11.44716346
36LATS11.44490445
37PIK3CG1.43667996
38PIK3CA1.35015709
39BMPR21.32344556
40SCYL21.30920462
41TGFBR21.26836815
42MAPK111.21570264
43ACVR1B1.21292763
44BLK1.20603875
45KDR1.19432389
46NEK11.17798041
47LIMK11.17651788
48BMPR1B1.14013709
49DMPK1.13670480
50JAK31.13566604
51CSK1.12138520
52ITK1.08834941
53DAPK31.08678645
54MAP3K71.08164347
55WNK41.06956566
56PIM21.06432140
57TESK11.06403250
58TAOK31.05210739
59SYK1.04962832
60TRPM71.04795381
61FRK1.04215189
62MAP3K30.98071471
63BTK0.97271855
64ROCK10.95224134
65ADRBK20.93805058
66IKBKE0.93404114
67PRKAA10.93024652
68MAP2K40.92142700
69ERBB40.90932178
70PTK60.90476785
71RIPK10.90142939
72MAPK120.90075437
73TYK20.89044129
74ARAF0.85166707
75TNK20.83456533
76ABL20.81966555
77LYN0.80495832
78STK240.80417052
79PRKCQ0.79767953
80PRKCE0.79655402
81ZAP700.79517340
82GRK10.76805369
83JAK10.74723205
84OXSR10.74709480
85IRAK30.73295183
86MAP4K10.72787125
87JAK20.72574212
88CAMKK20.72228833
89TBK10.71429968
90PRKACG0.69128479
91NUAK10.68045952
92IKBKB0.66802566
93PDPK10.66404615
94CAMK1G0.65582177
95MATK0.64628999
96FER0.62613865
97NLK0.60892486
98FGFR20.60665752
99LCK0.60222474
100PRKG10.58951893
101MAP3K110.58512088
102PRKD10.58511850
103MAPK40.58167315
104VRK20.55395339
105EPHB10.54986690
106EPHB20.53792425
107MAP2K10.53218490
108STK40.52900777
109MAP2K60.52864701
110PDK10.51804157
111VRK10.50830268
112MAP3K50.50433987
113ADRBK10.49989906
114GSK3A0.49522274
115MAPK70.49368318
116MET0.49081380
117MAPKAPK30.48712101
118IRAK40.48370606
119PDGFRA0.47606846
120CAMK40.47009551
121CAMK2G0.46904443
122GRK70.46115427
123PRKG20.45891400
124FGFR30.45659099
125MUSK0.44800269
126PAK30.44368221
127CDK60.42981105
128SGK30.42042298
129ILK0.40081864
130CDK40.39172724
131LRRK20.36203418
132IGF1R0.34726921
133STK30.31305927
134AKT20.29201855
135TGFBR10.27626691
136STK390.27439245
137PRKCZ0.27178347
138PRKACA0.27022761
139ERBB20.25394393
140TAOK20.25280591
141KIT0.24118589
142RET0.24031046
143EPHA30.23953883
144SGK20.23740806
145CSF1R0.23425723
146PRKACB0.23094685
147WNK30.22286293
148CAMK2D0.22245190
149DYRK1B0.22066092
150MTOR0.22040765
151TEC0.21390969

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid degradation_Homo sapiens_hsa000713.43490902
2Propanoate metabolism_Homo sapiens_hsa006403.38508765
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.33237309
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.29901256
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.94751584
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.82674592
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.79825258
8Nitrogen metabolism_Homo sapiens_hsa009102.73070532
9Fatty acid metabolism_Homo sapiens_hsa012122.72058228
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.68575002
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.62204558
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.57202652
13Tryptophan metabolism_Homo sapiens_hsa003802.51406831
14PPAR signaling pathway_Homo sapiens_hsa033202.44180918
15Butanoate metabolism_Homo sapiens_hsa006502.42260659
16Arginine biosynthesis_Homo sapiens_hsa002202.35669199
17Peroxisome_Homo sapiens_hsa041462.19220886
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.02253997
19Pyruvate metabolism_Homo sapiens_hsa006202.02224804
20Fatty acid elongation_Homo sapiens_hsa000621.95182637
21beta-Alanine metabolism_Homo sapiens_hsa004101.92796573
22Carbon metabolism_Homo sapiens_hsa012001.90061359
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.88958726
24Complement and coagulation cascades_Homo sapiens_hsa046101.84527908
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.84183891
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.64295879
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.51499724
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47498021
29Caffeine metabolism_Homo sapiens_hsa002321.46370453
30Chemical carcinogenesis_Homo sapiens_hsa052041.45022867
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.44962543
32Proteasome_Homo sapiens_hsa030501.39365541
33Histidine metabolism_Homo sapiens_hsa003401.37403401
34Starch and sucrose metabolism_Homo sapiens_hsa005001.34404583
35Sulfur metabolism_Homo sapiens_hsa009201.34291823
36Phenylalanine metabolism_Homo sapiens_hsa003601.33539247
37Asthma_Homo sapiens_hsa053101.33298365
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.29791853
39Biosynthesis of amino acids_Homo sapiens_hsa012301.27324744
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.26683801
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.25959319
42Retinol metabolism_Homo sapiens_hsa008301.24048956
43Protein export_Homo sapiens_hsa030601.22437318
44Tyrosine metabolism_Homo sapiens_hsa003501.19207939
45Selenocompound metabolism_Homo sapiens_hsa004501.18657871
46Fat digestion and absorption_Homo sapiens_hsa049751.18222726
47Bile secretion_Homo sapiens_hsa049761.17133684
48Allograft rejection_Homo sapiens_hsa053301.14755726
49Staphylococcus aureus infection_Homo sapiens_hsa051501.08135883
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.06146779
51Autoimmune thyroid disease_Homo sapiens_hsa053201.04431292
52Fatty acid biosynthesis_Homo sapiens_hsa000611.04166527
53Folate biosynthesis_Homo sapiens_hsa007901.04126592
54Graft-versus-host disease_Homo sapiens_hsa053321.03401393
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.00333723
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95676742
57Intestinal immune network for IgA production_Homo sapiens_hsa046720.95031180
58ABC transporters_Homo sapiens_hsa020100.93503164
59Glycerolipid metabolism_Homo sapiens_hsa005610.92886607
60Arginine and proline metabolism_Homo sapiens_hsa003300.91242928
61Lysine degradation_Homo sapiens_hsa003100.89385607
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89368355
63Type I diabetes mellitus_Homo sapiens_hsa049400.88553182
64Ribosome_Homo sapiens_hsa030100.85373260
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81904955
66Sulfur relay system_Homo sapiens_hsa041220.80711012
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80036366
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73064712
69Vitamin digestion and absorption_Homo sapiens_hsa049770.71954039
70Oxidative phosphorylation_Homo sapiens_hsa001900.70693345
71Glutathione metabolism_Homo sapiens_hsa004800.70681702
72Parkinsons disease_Homo sapiens_hsa050120.70657763
73Cyanoamino acid metabolism_Homo sapiens_hsa004600.68016194
74Pentose phosphate pathway_Homo sapiens_hsa000300.65596025
75Vitamin B6 metabolism_Homo sapiens_hsa007500.64215720
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.61449888
77Steroid biosynthesis_Homo sapiens_hsa001000.59897897
78Metabolic pathways_Homo sapiens_hsa011000.56743205
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54797487
80Rheumatoid arthritis_Homo sapiens_hsa053230.53526301
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.51526686
82Leishmaniasis_Homo sapiens_hsa051400.51514362
83Insulin resistance_Homo sapiens_hsa049310.50215974
84Primary immunodeficiency_Homo sapiens_hsa053400.49069160
85Viral myocarditis_Homo sapiens_hsa054160.47534633
86Antigen processing and presentation_Homo sapiens_hsa046120.44790020
87Alzheimers disease_Homo sapiens_hsa050100.41962257
88Galactose metabolism_Homo sapiens_hsa000520.41830712
89Fructose and mannose metabolism_Homo sapiens_hsa000510.41711324
90Hematopoietic cell lineage_Homo sapiens_hsa046400.41106825
91Mineral absorption_Homo sapiens_hsa049780.40011363
92Other glycan degradation_Homo sapiens_hsa005110.36151997
93AMPK signaling pathway_Homo sapiens_hsa041520.35700074
94Pertussis_Homo sapiens_hsa051330.34435855
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34388451
96Glucagon signaling pathway_Homo sapiens_hsa049220.34122224
97Cardiac muscle contraction_Homo sapiens_hsa042600.33972144
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33538065
99One carbon pool by folate_Homo sapiens_hsa006700.31741931
100Collecting duct acid secretion_Homo sapiens_hsa049660.28607742
101Huntingtons disease_Homo sapiens_hsa050160.26348890
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25857573
103Malaria_Homo sapiens_hsa051440.22086771
104Glycosaminoglycan degradation_Homo sapiens_hsa005310.19957586
105Insulin signaling pathway_Homo sapiens_hsa049100.18387126
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.16597061
107Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.16463581
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.15680970
109Linoleic acid metabolism_Homo sapiens_hsa005910.12849801
110Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.08453196
111Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.04056770
112Dilated cardiomyopathy_Homo sapiens_hsa054140.01483476
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.00135864
114ECM-receptor interaction_Homo sapiens_hsa04512-0.2066704
115Regulation of autophagy_Homo sapiens_hsa04140-0.1690689
116Renin-angiotensin system_Homo sapiens_hsa04614-0.1219472
117Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412-0.1119435
118Protein digestion and absorption_Homo sapiens_hsa04974-0.0868337
119Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0540456
120Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0506298
121Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0501725
122Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0360662
123Prion diseases_Homo sapiens_hsa05020-0.0162423
124Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0072020

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