DEDD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear-localized protein containing a death effector domain (DED). The encoded protein may regulate the trafficking of caspases and other proteins into the nucleus during death receptor-induced apoptosis. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.71646478
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.31813145
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.31813145
4positive regulation of gamma-delta T cell activation (GO:0046645)5.30539722
5positive regulation by symbiont of host defense response (GO:0052509)5.26427463
6modulation by symbiont of host defense response (GO:0052031)5.26427463
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.26427463
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.26427463
9positive regulation by organism of defense response of other organism involved in symbiotic interact5.26427463
10modulation by symbiont of host immune response (GO:0052553)5.26427463
11neutrophil activation involved in immune response (GO:0002283)4.80205259
12regulation of gamma-delta T cell differentiation (GO:0045586)4.75669275
13antigen processing and presentation of endogenous antigen (GO:0019883)4.75038790
14regulation of gamma-delta T cell activation (GO:0046643)4.49395189
15macrophage activation involved in immune response (GO:0002281)4.40925647
16response to peptidoglycan (GO:0032494)4.38036529
17positive thymic T cell selection (GO:0045059)4.19402067
18leukocyte aggregation (GO:0070486)4.08712629
19respiratory burst (GO:0045730)4.03064765
20regulation of mast cell degranulation (GO:0043304)4.02847750
21neutrophil activation (GO:0042119)3.97806219
22immunoglobulin mediated immune response (GO:0016064)3.90211862
23regulation of interferon-beta biosynthetic process (GO:0045357)3.84381208
24negative regulation of lymphocyte mediated immunity (GO:0002707)3.83311575
25detection of external biotic stimulus (GO:0098581)3.82506048
26granulocyte activation (GO:0036230)3.76429767
27response to host immune response (GO:0052572)3.74213048
28response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.74213048
29negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.71417364
30response to interleukin-15 (GO:0070672)3.69624086
31detection of bacterium (GO:0016045)3.64123067
32regulation of mast cell activation involved in immune response (GO:0033006)3.60553284
33positive T cell selection (GO:0043368)3.55956940
34protoporphyrinogen IX metabolic process (GO:0046501)3.53271957
35positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.53131646
36negative regulation of leukocyte mediated immunity (GO:0002704)3.51909060
37myeloid cell activation involved in immune response (GO:0002275)3.51070470
38regulation of myeloid leukocyte mediated immunity (GO:0002886)3.49832839
39thymic T cell selection (GO:0045061)3.49059670
40negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.45468470
41negative regulation of cell killing (GO:0031342)3.45468470
42interferon-gamma production (GO:0032609)3.43936828
43positive regulation of mast cell activation (GO:0033005)3.43726650
44regulation of leukocyte degranulation (GO:0043300)3.43093982
45detection of biotic stimulus (GO:0009595)3.42192351
46cellular response to interleukin-15 (GO:0071350)3.41199646
47response to host (GO:0075136)3.40938053
48response to host defenses (GO:0052200)3.40938053
49response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.40938053
50defense response to fungus (GO:0050832)3.34873956
51detection of molecule of bacterial origin (GO:0032490)3.34632031
52response to muramyl dipeptide (GO:0032495)3.30516365
53regulation of mast cell activation (GO:0033003)3.30386900
54neutrophil mediated immunity (GO:0002446)3.29786592
55T cell selection (GO:0045058)3.27800648
56negative regulation of T cell mediated immunity (GO:0002710)3.26563632
57regulation of T cell mediated cytotoxicity (GO:0001914)3.25988567
58positive regulation of T cell mediated cytotoxicity (GO:0001916)3.25877691
59negative T cell selection (GO:0043383)3.24315502
60microglial cell activation (GO:0001774)3.23679329
61leukocyte degranulation (GO:0043299)3.19809615
62macrophage activation (GO:0042116)3.14661968
63positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.13822205
64negative thymic T cell selection (GO:0045060)3.13454566
65leukocyte migration involved in inflammatory response (GO:0002523)3.13339376
66detection of other organism (GO:0098543)3.08890728
67regulation of B cell receptor signaling pathway (GO:0050855)3.05697483
68negative regulation of interleukin-6 production (GO:0032715)3.04340908
69regulation of T cell tolerance induction (GO:0002664)3.04151832
70positive regulation of mast cell activation involved in immune response (GO:0033008)3.04099012
71positive regulation of mast cell degranulation (GO:0043306)3.04099012
72protoporphyrinogen IX biosynthetic process (GO:0006782)3.03631460
73type I interferon signaling pathway (GO:0060337)3.02527670
74cellular response to type I interferon (GO:0071357)3.02527670
75regulation of tolerance induction (GO:0002643)3.01157144
76regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.00898047
77regulation of natural killer cell mediated immunity (GO:0002715)3.00898047
78response to type I interferon (GO:0034340)2.98880309
79negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.98130390
80erythrocyte maturation (GO:0043249)2.98071357
81NIK/NF-kappaB signaling (GO:0038061)2.95107224
82regulation of regulated secretory pathway (GO:1903305)2.94621290
83B cell mediated immunity (GO:0019724)2.94587262
84regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.92648450
85ribosomal small subunit assembly (GO:0000028)2.92416412
86defense response to protozoan (GO:0042832)2.90264722
87lipopolysaccharide-mediated signaling pathway (GO:0031663)2.89292280
88germinal center formation (GO:0002467)2.88375530
89negative regulation of erythrocyte differentiation (GO:0045647)2.86290664
90regulation of T-helper 2 cell differentiation (GO:0045628)2.84900679
91regulation of interleukin-12 biosynthetic process (GO:0045075)2.83338911
92heme biosynthetic process (GO:0006783)2.82908020
93regulation of B cell differentiation (GO:0045577)2.82541210
94tolerance induction (GO:0002507)2.80666433
95regulation of dendritic cell antigen processing and presentation (GO:0002604)2.80347647
96regulation of cholesterol homeostasis (GO:2000188)2.80219993
97killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.79383502
98disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.79383502
99positive regulation of B cell differentiation (GO:0045579)2.79344931
100megakaryocyte development (GO:0035855)2.77893844
101regulation of RIG-I signaling pathway (GO:0039535)2.76839789
102myeloid leukocyte mediated immunity (GO:0002444)2.75471271
103regulation of superoxide anion generation (GO:0032928)2.75396404
104cellular extravasation (GO:0045123)2.75005929
105interferon-gamma-mediated signaling pathway (GO:0060333)2.73956765
106negative regulation of cytokine production involved in immune response (GO:0002719)2.73899789
107DNA deamination (GO:0045006)2.72690697
108production of molecular mediator involved in inflammatory response (GO:0002532)2.71459722
109porphyrin-containing compound biosynthetic process (GO:0006779)2.70749560
110valine metabolic process (GO:0006573)2.70700216
111regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.70259481
112regulation of response to interferon-gamma (GO:0060330)2.69247398
113positive regulation of lipoprotein lipase activity (GO:0051006)2.68132459
114positive regulation of triglyceride lipase activity (GO:0061365)2.68132459
115glycine metabolic process (GO:0006544)2.67763768
116regulation of leukocyte mediated cytotoxicity (GO:0001910)2.67289108
117regulation of antigen processing and presentation (GO:0002577)2.65691664
118disruption of cells of other organism (GO:0044364)2.64312275
119killing of cells of other organism (GO:0031640)2.64312275
120mucosal-associated lymphoid tissue development (GO:0048537)2.62657288
121Peyers patch development (GO:0048541)2.62657288
122antigen processing and presentation via MHC class Ib (GO:0002475)2.60714663
123negative regulation of innate immune response (GO:0045824)2.59707088
124plasma lipoprotein particle assembly (GO:0034377)2.59420921
125positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.59381397
126viral transcription (GO:0019083)2.58693060
127serine family amino acid catabolic process (GO:0009071)2.53481295
128Arp2/3 complex-mediated actin nucleation (GO:0034314)2.51853307
129mature B cell differentiation (GO:0002335)2.50784238
130positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.48702215
131regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.48362548
132T cell migration (GO:0072678)2.48174852
133phospholipid efflux (GO:0033700)2.47136339
134negative regulation of interleukin-12 production (GO:0032695)2.46667283
135regulation of alpha-beta T cell proliferation (GO:0046640)2.45535410
136T cell homeostasis (GO:0043029)2.44851115
137cysteine metabolic process (GO:0006534)2.44780743
138intestinal cholesterol absorption (GO:0030299)2.44604134
139translational termination (GO:0006415)2.44241885
140heme metabolic process (GO:0042168)2.42953553
141negative regulation of glycoprotein biosynthetic process (GO:0010561)2.42670811
142B cell receptor signaling pathway (GO:0050853)2.42436123
143positive regulation of humoral immune response (GO:0002922)2.42260703
144T cell receptor signaling pathway (GO:0050852)2.41749994
145mature B cell differentiation involved in immune response (GO:0002313)2.41456810
146JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.40647005
147tetrapyrrole biosynthetic process (GO:0033014)2.40009194
148pantothenate metabolic process (GO:0015939)2.39987687
149positive regulation of histone deacetylation (GO:0031065)2.37668143
150porphyrin-containing compound metabolic process (GO:0006778)2.36863427
151indole-containing compound catabolic process (GO:0042436)2.36674515
152indolalkylamine catabolic process (GO:0046218)2.36674515
153tryptophan catabolic process (GO:0006569)2.36674515
154regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.35055489
155antigen receptor-mediated signaling pathway (GO:0050851)2.34908740
156folic acid metabolic process (GO:0046655)2.33180664
157positive regulation of isotype switching (GO:0045830)2.32740319
158regulation of type I interferon-mediated signaling pathway (GO:0060338)2.32307976
159regulation of natural killer cell differentiation (GO:0032823)2.29987809
160regulation of erythrocyte differentiation (GO:0045646)2.28534313
161negative regulation of phagocytosis (GO:0050765)2.26716700
162response to fungus (GO:0009620)2.26375662
163hepatocyte apoptotic process (GO:0097284)2.25786386
164amino-acid betaine metabolic process (GO:0006577)2.24643658
165chaperone mediated protein folding requiring cofactor (GO:0051085)2.24425303
166regulation of triglyceride catabolic process (GO:0010896)2.24340834

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human3.90144639
2E2F7_22180533_ChIP-Seq_HELA_Human3.50711844
3MYC_22102868_ChIP-Seq_BL_Human3.03063242
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.85059804
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.80372217
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.67035719
7SCL_19346495_ChIP-Seq_HPC-7_Human2.65056851
8* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.56043213
9VDR_21846776_ChIP-Seq_THP-1_Human2.43951933
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.34069547
11RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.27388711
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.25430681
13MAF_26560356_Chip-Seq_TH1_Human2.17196133
14RXR_22158963_ChIP-Seq_LIVER_Mouse2.13768760
15* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.09043342
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.08935450
17UTX_26944678_Chip-Seq_JUKART_Human2.01859608
18SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.99674381
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.98594621
20* TCF7_22412390_ChIP-Seq_EML_Mouse1.97404536
21STAT4_19710469_ChIP-ChIP_TH1__Mouse1.94283742
22MYB_26560356_Chip-Seq_TH2_Human1.93199793
23BRD4_27068464_Chip-Seq_AML-cells_Mouse1.88323222
24NOTCH1_21737748_ChIP-Seq_TLL_Human1.87848164
25* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.87646742
26EGR1_23403033_ChIP-Seq_LIVER_Mouse1.84796973
27RUNX1_22412390_ChIP-Seq_EML_Mouse1.84399432
28GATA1_19941827_ChIP-Seq_MEL_Mouse1.82588739
29* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.82183661
30* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.81915859
31GATA1_22025678_ChIP-Seq_K562_Human1.79912798
32FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.78436471
33MYB_26560356_Chip-Seq_TH1_Human1.78345952
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.77223667
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.75225034
36GATA1_22383799_ChIP-Seq_G1ME_Mouse1.69535835
37TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.68743869
38TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.66971634
39MAF_26560356_Chip-Seq_TH2_Human1.62064991
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.61676984
41EGR1_19374776_ChIP-ChIP_THP-1_Human1.61466469
42RUNX_20019798_ChIP-Seq_JUKART_Human1.61287743
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.61066888
44SPI1_23547873_ChIP-Seq_NB4_Human1.60044826
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.58904578
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.56011103
47FOXM1_23109430_ChIP-Seq_U2OS_Human1.55546198
48GATA2_22383799_ChIP-Seq_G1ME_Mouse1.54748624
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.54532928
50SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53805271
51NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.53657395
52* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.51059052
53VDR_24763502_ChIP-Seq_THP-1_Human1.50909471
54STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.50559404
55LXR_22158963_ChIP-Seq_LIVER_Mouse1.49979847
56LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.45935536
57CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44601578
58NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.43575103
59GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.40972955
60* GATA1_19941826_ChIP-Seq_K562_Human1.40250085
61CIITA_25753668_ChIP-Seq_RAJI_Human1.40121833
62SA1_27219007_Chip-Seq_ERYTHROID_Human1.39935595
63PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39172725
64* KDM2B_26808549_Chip-Seq_DND41_Human1.38313888
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35910393
66IRF8_27001747_Chip-Seq_BMDM_Mouse1.34399450
67IRF8_21731497_ChIP-ChIP_J774_Mouse1.33186871
68* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33072894
69VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.32184418
70LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.30517233
71STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.30343854
72* FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.28817159
73TP63_17297297_ChIP-ChIP_HaCaT_Human1.28420848
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.26699891
75CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26157593
76NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.25707403
77CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25176216
78BCOR_27268052_Chip-Seq_Bcells_Human1.24668208
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24488865
80* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.23532889
81SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.23510091
82LXR_22292898_ChIP-Seq_THP-1_Human1.22894118
83ELK3_25401928_ChIP-Seq_HUVEC_Human1.20484911
84KDM2B_26808549_Chip-Seq_JURKAT_Human1.20006983
85GATA3_27048872_Chip-Seq_THYMUS_Human1.17878769
86BCL6_27268052_Chip-Seq_Bcells_Human1.17770511
87NCOR1_26117541_ChIP-Seq_K562_Human1.15930834
88THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15894884
89CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14611308
90TET1_21451524_ChIP-Seq_MESCs_Mouse1.14328926
91GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14090672
92SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.13178959
93SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11960463
94* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.11567640
95YY1_22570637_ChIP-Seq_MALME-3M_Human1.10597631
96RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.10299218
97CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09659994
98ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09603905
99P68_20966046_ChIP-Seq_HELA_Human1.08698551
100RACK7_27058665_Chip-Seq_MCF-7_Human1.08191053
101E2F1_20622854_ChIP-Seq_HELA_Human1.07675458
102VDR_23849224_ChIP-Seq_CD4+_Human1.07527368
103CTCF_26484167_Chip-Seq_Bcells_Mouse1.06029935
104SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04892051
105P300_27268052_Chip-Seq_Bcells_Human1.04748860
106EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.03634216
107KDM5A_27292631_Chip-Seq_BREAST_Human1.03032583
108SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.02662956
109CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02228569
110FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.02044251
111CTCF_21964334_ChIP-Seq_BJAB-B_Human1.01588785
112SPI1_20517297_ChIP-Seq_HL60_Human1.01028478
113* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00826709
114ELF1_20517297_ChIP-Seq_JURKAT_Human1.00638153
115SA1_27219007_Chip-Seq_Bcells_Human1.00409387
116SPI1_23127762_ChIP-Seq_K562_Human1.00025989
117PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00015122
118GATA3_26560356_Chip-Seq_TH2_Human0.99889897
119FOXP3_21729870_ChIP-Seq_TREG_Human0.99594291
120* GATA2_19941826_ChIP-Seq_K562_Human0.99360201
121VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.99004464
122ZNF263_19887448_ChIP-Seq_K562_Human0.97828777
123CTCF_27219007_Chip-Seq_ERYTHROID_Human0.97518299
124PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94289789
125PHF8_20622854_ChIP-Seq_HELA_Human0.93885412
126* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91312278
127KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91189960

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo2.87241349
2MP0003763_abnormal_thymus_physiology2.79022457
3MP0009840_abnormal_foam_cell2.72217493
4MP0000685_abnormal_immune_system2.66694475
5MP0005360_urolithiasis2.53945008
6MP0001800_abnormal_humoral_immune2.36089645
7MP0005671_abnormal_response_to2.34746988
8MP0001835_abnormal_antigen_presentation2.24885552
9MP0008260_abnormal_autophagy2.24568173
10MP0002139_abnormal_hepatobiliary_system2.23314339
11MP0003436_decreased_susceptibility_to2.21668061
12MP0001790_abnormal_immune_system2.20759826
13MP0005387_immune_system_phenotype2.20759826
14MP0009785_altered_susceptibility_to2.18614868
15MP0003191_abnormal_cellular_cholesterol2.17998502
16MP0005365_abnormal_bile_salt2.07052842
17MP0004947_skin_inflammation2.05378063
18MP0002398_abnormal_bone_marrow2.01604925
19MP0001873_stomach_inflammation1.98406648
20MP0005025_abnormal_response_to1.97753229
21MP0010155_abnormal_intestine_physiology1.97708487
22MP0010234_abnormal_vibrissa_follicle1.97602768
23MP0002723_abnormal_immune_serum1.96758325
24MP0001533_abnormal_skeleton_physiology1.93451746
25MP0003172_abnormal_lysosome_physiology1.93415154
26MP0002420_abnormal_adaptive_immunity1.92367808
27MP0001819_abnormal_immune_cell1.91169380
28MP0005000_abnormal_immune_tolerance1.89403671
29MP0005085_abnormal_gallbladder_physiolo1.89098056
30MP0003866_abnormal_defecation1.89043830
31MP0002452_abnormal_antigen_presenting1.88622410
32MP0004381_abnormal_hair_follicle1.85393403
33MP0003693_abnormal_embryo_hatching1.84052043
34MP0001545_abnormal_hematopoietic_system1.82401163
35MP0005397_hematopoietic_system_phenotyp1.82401163
36MP0009333_abnormal_splenocyte_physiolog1.79068469
37MP0003303_peritoneal_inflammation1.78460161
38MP0000490_abnormal_crypts_of1.77944602
39MP0002722_abnormal_immune_system1.73310333
40MP0000716_abnormal_immune_system1.73282814
41MP0002166_altered_tumor_susceptibility1.72544555
42MP0000689_abnormal_spleen_morphology1.72503099
43MP0009278_abnormal_bone_marrow1.71587892
44MP0005464_abnormal_platelet_physiology1.70407850
45MP0005451_abnormal_body_composition1.68158408
46MP0002396_abnormal_hematopoietic_system1.67179112
47MP0002405_respiratory_system_inflammati1.62708168
48MP0002138_abnormal_hepatobiliary_system1.61653009
49MP0002419_abnormal_innate_immunity1.60170896
50MP0002277_abnormal_respiratory_mucosa1.60159360
51MP0005058_abnormal_lysosome_morphology1.59676493
52MP0003300_gastrointestinal_ulcer1.59361508
53MP0002429_abnormal_blood_cell1.56561927
54MP0001666_abnormal_nutrient_absorption1.53934965
55MP0001845_abnormal_inflammatory_respons1.53615015
56MP0000703_abnormal_thymus_morphology1.50641510
57MP0002796_impaired_skin_barrier1.50070870
58MP0001853_heart_inflammation1.48549352
59MP0000609_abnormal_liver_physiology1.40611786
60MP0003828_pulmonary_edema1.40553537
61MP0003724_increased_susceptibility_to1.40129800
62MP0002132_abnormal_respiratory_system1.38108527
63MP0005310_abnormal_salivary_gland1.36913406
64MP0004147_increased_porphyrin_level1.35439299
65MP0000465_gastrointestinal_hemorrhage1.32266595
66MP0002653_abnormal_ependyma_morphology1.32261395
67MP0004808_abnormal_hematopoietic_stem1.31648660
68MP0003806_abnormal_nucleotide_metabolis1.30305782
69MP0003111_abnormal_nucleus_morphology1.29502389
70MP0002148_abnormal_hypersensitivity_rea1.27123863
71MP0003453_abnormal_keratinocyte_physiol1.24150962
72MP0002006_tumorigenesis1.23619798
73MP0008469_abnormal_protein_level1.22745102
74MP0003075_altered_response_to1.21638609
75MP0008875_abnormal_xenobiotic_pharmacok1.19216965
76MP0001216_abnormal_epidermal_layer1.17733605
77MP0005501_abnormal_skin_physiology1.17521435
78MP0010329_abnormal_lipoprotein_level1.16845267
79MP0009764_decreased_sensitivity_to1.13753920
80MP0001851_eye_inflammation1.12661771
81MP0005075_abnormal_melanosome_morpholog1.12642966
82MP0000343_altered_response_to1.11582510
83MP0005377_hearing/vestibular/ear_phenot1.10824530
84MP0003878_abnormal_ear_physiology1.10824530
85MP0002998_abnormal_bone_remodeling1.10763697
86MP0003183_abnormal_peptide_metabolism1.10318211
87MP0001764_abnormal_homeostasis1.07301897
88MP0006082_CNS_inflammation1.05518612
89MP0005083_abnormal_biliary_tract1.05498688
90MP0002019_abnormal_tumor_incidence1.03447936
91MP0000858_altered_metastatic_potential1.02912197
92MP0008004_abnormal_stomach_pH0.99772404
93MP0005166_decreased_susceptibility_to0.99271681
94MP0004510_myositis0.98509738
95MP0000604_amyloidosis0.97535932
96MP0009643_abnormal_urine_homeostasis0.96171705
97MP0009931_abnormal_skin_appearance0.93431772
98MP0003252_abnormal_bile_duct0.92944049
99MP0001663_abnormal_digestive_system0.92481778
100MP0004264_abnormal_extraembryonic_tissu0.91614743
101MP0008057_abnormal_DNA_replication0.89467556
102MP0004883_abnormal_blood_vessel0.88713880
103MP0005636_abnormal_mineral_homeostasis0.88278255
104MP0003077_abnormal_cell_cycle0.87150336
105MP0004019_abnormal_vitamin_homeostasis0.86457900
106MP0010352_gastrointestinal_tract_polyps0.83772056
107MP0009765_abnormal_xenobiotic_induced0.83752398
108MP0009763_increased_sensitivity_to0.82118071
109MP0000383_abnormal_hair_follicle0.81811537
110MP0002254_reproductive_system_inflammat0.81515796
111MP0003868_abnormal_feces_composition0.81504915
112MP0005319_abnormal_enzyme/_coenzyme0.80891991
113MP0000477_abnormal_intestine_morphology0.80569101
114MP0005332_abnormal_amino_acid0.80200838
115MP0005164_abnormal_response_to0.79198304
116MP0005390_skeleton_phenotype0.79155115
117MP0005174_abnormal_tail_pigmentation0.77936077
118MP0008058_abnormal_DNA_repair0.77132407
119MP0000598_abnormal_liver_morphology0.75730358
120MP0002118_abnormal_lipid_homeostasis0.75030934
121MP0000377_abnormal_hair_follicle0.74973176
122MP0002098_abnormal_vibrissa_morphology0.74357275
123MP0003329_amyloid_beta_deposits0.70373822
124MP0003448_altered_tumor_morphology0.69289524
125MP0002933_joint_inflammation0.67309286
126MP0003690_abnormal_glial_cell0.66874961
127MP0008874_decreased_physiological_sensi0.65888190
128MP0003221_abnormal_cardiomyocyte_apopto0.64274831
129MP0003795_abnormal_bone_structure0.59731543
130MP0001986_abnormal_taste_sensitivity0.57948312
131MP0002332_abnormal_exercise_endurance0.55452289
132MP0002693_abnormal_pancreas_physiology0.54364231
133MP0000249_abnormal_blood_vessel0.53399648
134MP0008873_increased_physiological_sensi0.52762444
135MP0005584_abnormal_enzyme/coenzyme_acti0.52664565
136MP0003011_delayed_dark_adaptation0.50383119
137MP0000015_abnormal_ear_pigmentation0.49162690

Predicted human phenotypes

RankGene SetZ-score
1Pustule (HP:0200039)4.78203900
2Optic neuritis (HP:0100653)4.51227601
3Retrobulbar optic neuritis (HP:0100654)4.51227601
4Poikilocytosis (HP:0004447)3.99030518
5Abnormal delayed hypersensitivity skin test (HP:0002963)3.87572199
6Eczematoid dermatitis (HP:0000976)3.77826936
7Increased IgE level (HP:0003212)3.74603797
8IgM deficiency (HP:0002850)3.63947976
9Chronic otitis media (HP:0000389)3.55387889
10T lymphocytopenia (HP:0005403)3.54854372
11Recurrent fungal infections (HP:0002841)3.54533402
12Gastrointestinal infarctions (HP:0005244)3.49807050
13Abnormality of T cell number (HP:0011839)3.41271280
14Abnormality of the heme biosynthetic pathway (HP:0010472)3.39972476
15Nasal polyposis (HP:0100582)3.24633160
16Acanthocytosis (HP:0001927)3.16875302
17Abnormality of T cells (HP:0002843)3.16480593
18Keratoconjunctivitis sicca (HP:0001097)3.15549437
19Panhypogammaglobulinemia (HP:0003139)3.11785493
20Abnormal number of erythroid precursors (HP:0012131)3.11735970
21Inflammation of the large intestine (HP:0002037)3.11125445
22Petechiae (HP:0000967)3.11063493
23Abnormality of cells of the erythroid lineage (HP:0012130)3.09677300
24Recurrent bronchitis (HP:0002837)3.09074283
25Gastrointestinal inflammation (HP:0004386)3.07887856
26Recurrent viral infections (HP:0004429)3.06906210
27Keratoconjunctivitis (HP:0001096)3.05962371
28Hypochromic anemia (HP:0001931)3.01025036
29Gingivitis (HP:0000230)2.98928309
30Microcytic anemia (HP:0001935)2.97208620
31Abnormality of the nasal mucosa (HP:0000433)2.93862704
32Increased cerebral lipofuscin (HP:0011813)2.88199860
33Increased IgM level (HP:0003496)2.84955792
34Spontaneous hematomas (HP:0007420)2.83695008
35Episodic fever (HP:0001954)2.83062810
36Abnormality of T cell physiology (HP:0011840)2.81198755
37Colitis (HP:0002583)2.78152765
38Meningitis (HP:0001287)2.77031712
39Recurrent sinusitis (HP:0011108)2.73288726
40Prolonged bleeding time (HP:0003010)2.72758464
41Combined immunodeficiency (HP:0005387)2.71823593
42Abnormality of glycolipid metabolism (HP:0010969)2.71033468
43Abnormality of liposaccharide metabolism (HP:0010968)2.71033468
44Abnormality of glycosphingolipid metabolism (HP:0004343)2.71033468
45Epistaxis (HP:0000421)2.68506250
46Recurrent abscess formation (HP:0002722)2.66182144
47Abnormality of aromatic amino acid family metabolism (HP:0004338)2.64301293
48Encephalitis (HP:0002383)2.63676684
49Pulmonary infiltrates (HP:0002113)2.62281837
50Chronic mucocutaneous candidiasis (HP:0002728)2.62110864
51Recurrent cutaneous fungal infections (HP:0011370)2.62110864
52Increased neuronal autofluorescent lipopigment (HP:0002074)2.58185198
53Anorexia (HP:0002039)2.57474234
54Abnormality of the fingertips (HP:0001211)2.57162811
55Loss of speech (HP:0002371)2.55361087
56Elevated erythrocyte sedimentation rate (HP:0003565)2.55049792
57Recurrent bacterial skin infections (HP:0005406)2.54721771
58Myositis (HP:0100614)2.54353564
59Severe combined immunodeficiency (HP:0004430)2.53347349
60Chest pain (HP:0100749)2.53142223
61Abnormality of monocarboxylic acid metabolism (HP:0010996)2.52846479
62Autoimmune thrombocytopenia (HP:0001973)2.48825675
63Impaired platelet aggregation (HP:0003540)2.48764832
64Abnormal platelet function (HP:0011869)2.48764832
65Thrombocytosis (HP:0001894)2.45349210
66Purpura (HP:0000979)2.44605291
67Poikiloderma (HP:0001029)2.43454732
68Abnormality of eosinophils (HP:0001879)2.43291574
69Gingival bleeding (HP:0000225)2.41456674
70Hypergammaglobulinemia (HP:0010702)2.40429111
71Agammaglobulinemia (HP:0004432)2.39164867
72Reticulocytosis (HP:0001923)2.38676370
73Cheilitis (HP:0100825)2.37953302
74Granulocytopenia (HP:0001913)2.37421150
75Osteomyelitis (HP:0002754)2.35861978
76Recurrent gram-negative bacterial infections (HP:0005420)2.35723531
77Eosinophilia (HP:0001880)2.35335462
78Chronic obstructive pulmonary disease (HP:0006510)2.33247764
79Obstructive lung disease (HP:0006536)2.33247764
80Sepsis (HP:0100806)2.32243659
81Abnormality of reticulocytes (HP:0004312)2.31745569
82Urticaria (HP:0001025)2.31707823
83B lymphocytopenia (HP:0010976)2.29877227
84Abnormality of B cell number (HP:0010975)2.29877227
85Polycythemia (HP:0001901)2.27972111
86Recurrent skin infections (HP:0001581)2.26280609
87Verrucae (HP:0200043)2.25623807
88Papilloma (HP:0012740)2.25623807
89Entropion (HP:0000621)2.25565830
90Slow saccadic eye movements (HP:0000514)2.23807755
91Gangrene (HP:0100758)2.23681042
92Vasculitis (HP:0002633)2.23122224
93Amyloidosis (HP:0011034)2.22666751
94Joint hemorrhage (HP:0005261)2.21751886
95Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.21386332
96Reticulocytopenia (HP:0001896)2.19424146
97Hyperbilirubinemia (HP:0002904)2.18840295
98Lymphopenia (HP:0001888)2.18196238
99Hepatosplenomegaly (HP:0001433)2.18072335
100Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.17979704
101Leukocytosis (HP:0001974)2.15162457
102Abnormality of cells of the lymphoid lineage (HP:0012140)2.14729623
103Cellulitis (HP:0100658)2.13783369
104Intrahepatic cholestasis (HP:0001406)2.13572530
105Xanthomatosis (HP:0000991)2.12754964
106Hypochromic microcytic anemia (HP:0004840)2.12428273
107Vacuolated lymphocytes (HP:0001922)2.11193192
108Hyperlipoproteinemia (HP:0010980)2.11117684
109Pulmonary embolism (HP:0002204)2.09951988
110Glomerulopathy (HP:0100820)2.09922687
111Stomatitis (HP:0010280)2.09013839
112Thyroiditis (HP:0100646)2.08770349
113Mediastinal lymphadenopathy (HP:0100721)2.07659917
114Arterial thrombosis (HP:0004420)2.07633345
115IgG deficiency (HP:0004315)2.05400111
116Interstitial pulmonary disease (HP:0006530)2.04834357
117Hypertensive crisis (HP:0100735)2.02182627
118Prolonged partial thromboplastin time (HP:0003645)2.01404352
119Bronchitis (HP:0012387)2.01297209
120Skin rash (HP:0000988)1.99707464
121Abnormality of macrophages (HP:0004311)1.99585023
122Increased serum ferritin (HP:0003281)1.99460254
123Acne (HP:0001061)1.99069633
124Seborrheic dermatitis (HP:0001051)1.98833118
125Abnormality of pyrimidine metabolism (HP:0004353)1.98431706
126Hyperglycinuria (HP:0003108)1.97849176
127Joint swelling (HP:0001386)1.97177910
128Abnormality of iron homeostasis (HP:0011031)1.95746142
129Abnormality of the pleura (HP:0002103)1.94971990
130Lymphoma (HP:0002665)1.94908362
131Keratitis (HP:0000491)1.94688683
132Chronic sinusitis (HP:0011109)1.94493970
133Skin ulcer (HP:0200042)1.93267799
134Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.92721020
135Hemoptysis (HP:0002105)1.91898986
136Acute hepatic failure (HP:0006554)1.90841514
137Orchitis (HP:0100796)1.90774232
138Abnormality of transition element cation homeostasis (HP:0011030)1.90541763
139Basal cell carcinoma (HP:0002671)1.90024752
140Premature loss of primary teeth (HP:0006323)1.85783038
141Recurrent pneumonia (HP:0006532)1.85208563

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.91382719
2GRK63.11308275
3BLK2.80760748
4MAP3K102.67813151
5TXK2.44518386
6STK102.28687997
7IRAK32.24051208
8PRPF4B2.19503039
9TYK22.19481520
10ZAP702.11367113
11TAOK32.09707380
12FGFR42.09119207
13ERN12.06624659
14BTK1.81509205
15IKBKE1.74287670
16EEF2K1.71636483
17PIM11.66120812
18ITK1.65977542
19NLK1.64090884
20MAP2K31.59052218
21TBK11.54400227
22MAP3K141.52875104
23SIK31.50899725
24DYRK31.48310728
25IRAK41.44656060
26TAOK21.44146379
27NEK21.41578049
28TEC1.40524004
29CDK121.40328322
30SYK1.39669995
31IKBKB1.39295728
32JAK31.39257653
33EPHB11.37109366
34MARK31.33323766
35CSK1.31023721
36MST41.28739574
37JAK11.27066897
38RPS6KA41.25123845
39FGR1.21536585
40MAP3K31.19667220
41MATK1.15777776
42MAP2K21.14132914
43MAP3K111.12797628
44EIF2AK11.11213787
45NME21.08909190
46HCK1.05900976
47TAOK11.05843378
48CDK41.04471111
49STK41.00692880
50MAPK110.99197550
51BCKDK0.98784341
52TRIB30.98537404
53PTK60.97170923
54LCK0.95524228
55JAK20.93651709
56MARK20.93587837
57RPS6KB20.93371276
58KSR20.92331046
59LRRK20.91374413
60SMG10.91108864
61CDK190.87858295
62CHUK0.86631645
63GRK10.86529880
64KDR0.86189648
65TNK20.85830961
66BRSK20.85703668
67HIPK20.84901581
68PKN20.83230359
69STK240.83207247
70SIK10.82828995
71DYRK1B0.82684292
72LYN0.82654783
73PDK10.82640665
74TESK10.82384051
75FLT30.82325471
76IRAK20.81479062
77ARAF0.79380882
78TLK10.77087981
79MAP3K70.76796509
80KIT0.76260184
81MAP2K60.75329325
82MAP3K50.73203155
83EPHA30.72488923
84MAPKAPK30.72029174
85PDPK10.71387660
86GRK70.69985541
87CAMKK10.68668684
88FES0.68151584
89IRAK10.67959705
90RPS6KA50.67317721
91MAPK120.65211209
92MAP2K40.63790020
93MAP4K20.62728694
94MAP3K80.62531461
95ALK0.62093952
96RIPK10.60943501
97ACVR1B0.57948132
98MELK0.57660078
99FYN0.57475284
100RPS6KC10.57366678
101RPS6KL10.57366678
102CLK10.56412272
103MAP3K10.56375985
104MAPK40.56263570
105FGFR30.55936256
106WEE10.55919564
107CSF1R0.52264362
108MAP3K130.51994338
109TSSK60.51772727
110STK380.51660870
111TGFBR20.51660565
112RPS6KA60.51210063
113RAF10.50742734
114CDK30.50240317
115CAMKK20.49995476
116MAPK150.49646083
117PRKCQ0.48746199
118SIK20.48061780
119RIPK40.47866089
120MAP3K120.44801479
121STK160.44762716
122MAPKAPK20.44083981
123TESK20.43144542
124PIM20.41311198
125PRKD20.40646266
126BUB10.39852514
127EPHA20.39658454
128YES10.38998296
129EIF2AK30.37919004
130BMX0.37776108
131MAPK70.37514375
132PRKCI0.37301774
133CDC42BPA0.37139072
134RPS6KA10.36509344
135STK110.35089948
136BRAF0.34261881
137PTK2B0.32976047
138PRKCD0.31244502
139MAP3K60.30950687
140PRKCZ0.30708238

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.48485683
2Autoimmune thyroid disease_Homo sapiens_hsa053202.28952397
3Cyanoamino acid metabolism_Homo sapiens_hsa004602.28809921
4Sulfur relay system_Homo sapiens_hsa041222.13355648
5NF-kappa B signaling pathway_Homo sapiens_hsa040641.97019480
6Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.95740735
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.90109634
8ABC transporters_Homo sapiens_hsa020101.89970104
9Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.88119767
10Vitamin B6 metabolism_Homo sapiens_hsa007501.87011270
11Type I diabetes mellitus_Homo sapiens_hsa049401.85694964
12Intestinal immune network for IgA production_Homo sapiens_hsa046721.82774592
13Folate biosynthesis_Homo sapiens_hsa007901.77205948
14B cell receptor signaling pathway_Homo sapiens_hsa046621.77052889
15Hematopoietic cell lineage_Homo sapiens_hsa046401.74221943
16Malaria_Homo sapiens_hsa051441.72089837
17T cell receptor signaling pathway_Homo sapiens_hsa046601.71278717
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.69679373
19Antigen processing and presentation_Homo sapiens_hsa046121.69271277
20Measles_Homo sapiens_hsa051621.69229245
21Staphylococcus aureus infection_Homo sapiens_hsa051501.65558677
22Caffeine metabolism_Homo sapiens_hsa002321.63541885
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.59767347
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.57720259
25Ribosome_Homo sapiens_hsa030101.57033308
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.51079088
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.49628386
28Viral myocarditis_Homo sapiens_hsa054161.48879034
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.48872400
30Phagosome_Homo sapiens_hsa041451.48762257
31Histidine metabolism_Homo sapiens_hsa003401.48465357
32Rheumatoid arthritis_Homo sapiens_hsa053231.46748253
33Osteoclast differentiation_Homo sapiens_hsa043801.46234881
34Leishmaniasis_Homo sapiens_hsa051401.42795492
35Herpes simplex infection_Homo sapiens_hsa051681.42221667
36Acute myeloid leukemia_Homo sapiens_hsa052211.41621931
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.38087538
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.34222610
39beta-Alanine metabolism_Homo sapiens_hsa004101.32523955
40Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.31801663
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.31080167
42Fat digestion and absorption_Homo sapiens_hsa049751.30875834
43Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.28866933
44Salmonella infection_Homo sapiens_hsa051321.28459775
45Lysosome_Homo sapiens_hsa041421.26639085
46NOD-like receptor signaling pathway_Homo sapiens_hsa046211.25587638
47Shigellosis_Homo sapiens_hsa051311.22164308
48Collecting duct acid secretion_Homo sapiens_hsa049661.20600673
49Tryptophan metabolism_Homo sapiens_hsa003801.19091783
50Pentose phosphate pathway_Homo sapiens_hsa000301.18879560
51DNA replication_Homo sapiens_hsa030301.18378580
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.17242656
53Asthma_Homo sapiens_hsa053101.16921053
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.14294409
55African trypanosomiasis_Homo sapiens_hsa051431.04789831
56Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.04783107
57Non-small cell lung cancer_Homo sapiens_hsa052231.03921272
58Pentose and glucuronate interconversions_Homo sapiens_hsa000401.02498162
59Apoptosis_Homo sapiens_hsa042101.01941737
60Influenza A_Homo sapiens_hsa051641.00934977
61Pertussis_Homo sapiens_hsa051331.00301769
62Vitamin digestion and absorption_Homo sapiens_hsa049770.99913987
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.98257932
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.97562551
65Complement and coagulation cascades_Homo sapiens_hsa046100.97183448
66Endocytosis_Homo sapiens_hsa041440.96489539
67VEGF signaling pathway_Homo sapiens_hsa043700.93375934
68Hepatitis C_Homo sapiens_hsa051600.91740816
69One carbon pool by folate_Homo sapiens_hsa006700.91641679
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90734455
71Regulation of autophagy_Homo sapiens_hsa041400.89864084
72Notch signaling pathway_Homo sapiens_hsa043300.88970897
73Base excision repair_Homo sapiens_hsa034100.88946150
74Arginine biosynthesis_Homo sapiens_hsa002200.87957541
75Toxoplasmosis_Homo sapiens_hsa051450.84093704
76Glycerolipid metabolism_Homo sapiens_hsa005610.83010180
77Hepatitis B_Homo sapiens_hsa051610.82550910
78Selenocompound metabolism_Homo sapiens_hsa004500.82156384
79Fatty acid degradation_Homo sapiens_hsa000710.80073759
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79168900
81Platelet activation_Homo sapiens_hsa046110.78489380
82Insulin resistance_Homo sapiens_hsa049310.78156109
83Toll-like receptor signaling pathway_Homo sapiens_hsa046200.77653633
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77071073
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.75710353
86Pancreatic cancer_Homo sapiens_hsa052120.73723009
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.73229828
88p53 signaling pathway_Homo sapiens_hsa041150.72892946
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.71234739
90Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.71069266
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70621681
92Retinol metabolism_Homo sapiens_hsa008300.68482753
93Other glycan degradation_Homo sapiens_hsa005110.68277144
94Lysine degradation_Homo sapiens_hsa003100.68177532
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.68152237
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67884493
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.67521156
98Epstein-Barr virus infection_Homo sapiens_hsa051690.67361972
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.66996072
100TNF signaling pathway_Homo sapiens_hsa046680.66537404
101Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65547057
102Graft-versus-host disease_Homo sapiens_hsa053320.65316793
103Chronic myeloid leukemia_Homo sapiens_hsa052200.64828219
104Chemokine signaling pathway_Homo sapiens_hsa040620.63897759
105Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63767413
106Peroxisome_Homo sapiens_hsa041460.62931631
107Systemic lupus erythematosus_Homo sapiens_hsa053220.62654715
108FoxO signaling pathway_Homo sapiens_hsa040680.60250271
109Legionellosis_Homo sapiens_hsa051340.59838696
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59488858
111Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58477604
112Bile secretion_Homo sapiens_hsa049760.58199142
113Chemical carcinogenesis_Homo sapiens_hsa052040.53653817
114HTLV-I infection_Homo sapiens_hsa051660.53506275
115Pyrimidine metabolism_Homo sapiens_hsa002400.53285966
116Mismatch repair_Homo sapiens_hsa034300.53155504
117Prolactin signaling pathway_Homo sapiens_hsa049170.52500761
118Glutathione metabolism_Homo sapiens_hsa004800.52338886
119Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50979031
120Homologous recombination_Homo sapiens_hsa034400.49920056
121MAPK signaling pathway_Homo sapiens_hsa040100.49900116
122Renal cell carcinoma_Homo sapiens_hsa052110.49885313
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49818162
124Phenylalanine metabolism_Homo sapiens_hsa003600.48041824
125Galactose metabolism_Homo sapiens_hsa000520.47993351
126Starch and sucrose metabolism_Homo sapiens_hsa005000.47326525
127Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46828805
128Viral carcinogenesis_Homo sapiens_hsa052030.46533105
129Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46482466
130Allograft rejection_Homo sapiens_hsa053300.46089519
131Spliceosome_Homo sapiens_hsa030400.45317036
132Tuberculosis_Homo sapiens_hsa051520.45036498
133Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43857673
134Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43399407
135Bladder cancer_Homo sapiens_hsa052190.43024214
136Synaptic vesicle cycle_Homo sapiens_hsa047210.41220651
137Phospholipase D signaling pathway_Homo sapiens_hsa040720.40017216
138GnRH signaling pathway_Homo sapiens_hsa049120.38463247
139Choline metabolism in cancer_Homo sapiens_hsa052310.37940654
140Vibrio cholerae infection_Homo sapiens_hsa051100.35180273
141Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34934882
142HIF-1 signaling pathway_Homo sapiens_hsa040660.34596768
143Endometrial cancer_Homo sapiens_hsa052130.33097561
144Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32504969
145mTOR signaling pathway_Homo sapiens_hsa041500.31456600
146Type II diabetes mellitus_Homo sapiens_hsa049300.30925465
147Colorectal cancer_Homo sapiens_hsa052100.27090521
148Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.26848541
149Arachidonic acid metabolism_Homo sapiens_hsa005900.26086481
150ErbB signaling pathway_Homo sapiens_hsa040120.26078417
151Inositol phosphate metabolism_Homo sapiens_hsa005620.25350966

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