DEF8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.20650409
2negative regulation of cell killing (GO:0031342)6.20650409
3ribosomal small subunit assembly (GO:0000028)5.90782286
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.67273015
5positive regulation by organism of defense response of other organism involved in symbiotic interact5.67273015
6modulation by symbiont of host immune response (GO:0052553)5.67273015
7positive regulation by symbiont of host defense response (GO:0052509)5.67273015
8modulation by symbiont of host defense response (GO:0052031)5.67273015
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.67273015
10endosome to melanosome transport (GO:0035646)5.48154945
11endosome to pigment granule transport (GO:0043485)5.48154945
12positive regulation of gamma-delta T cell activation (GO:0046645)5.17329129
13antigen processing and presentation of endogenous antigen (GO:0019883)5.14469122
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.13165081
15macrophage activation involved in immune response (GO:0002281)5.05388952
16neutrophil activation involved in immune response (GO:0002283)5.04196306
17detection of other organism (GO:0098543)4.91367323
18definitive hemopoiesis (GO:0060216)4.90194792
19detection of bacterium (GO:0016045)4.75969606
20regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.67047729
21negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.66444816
22platelet dense granule organization (GO:0060155)4.66273829
23antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.60751077
24response to peptidoglycan (GO:0032494)4.51781298
25regulation of interferon-beta biosynthetic process (GO:0045357)4.34228278
26respiratory burst (GO:0045730)4.34138548
27regulation of B cell receptor signaling pathway (GO:0050855)4.27850476
28detection of external biotic stimulus (GO:0098581)4.25926325
29urate metabolic process (GO:0046415)4.24164339
30valine metabolic process (GO:0006573)4.24063320
31leukocyte aggregation (GO:0070486)4.23991921
32megakaryocyte development (GO:0035855)4.20727338
33B cell receptor signaling pathway (GO:0050853)4.15080417
34regulation of acyl-CoA biosynthetic process (GO:0050812)4.12761854
35detection of molecule of bacterial origin (GO:0032490)4.08261326
36leukocyte migration involved in inflammatory response (GO:0002523)4.06258641
37cellular extravasation (GO:0045123)4.05203401
38neutrophil activation (GO:0042119)3.99817902
39negative regulation of interleukin-12 production (GO:0032695)3.99653576
40negative regulation of erythrocyte differentiation (GO:0045647)3.99613546
41regulation of T-helper 2 cell differentiation (GO:0045628)3.97372201
42viral transcription (GO:0019083)3.94906019
43positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.91498530
44regulation of mast cell degranulation (GO:0043304)3.86073143
45production of molecular mediator involved in inflammatory response (GO:0002532)3.84639788
46lysine catabolic process (GO:0006554)3.82200392
47lysine metabolic process (GO:0006553)3.82200392
48regulation of coenzyme metabolic process (GO:0051196)3.81480218
49regulation of cofactor metabolic process (GO:0051193)3.81480218
50translational termination (GO:0006415)3.80536758
51germinal center formation (GO:0002467)3.77163552
52granulocyte activation (GO:0036230)3.75850267
53drug transmembrane transport (GO:0006855)3.75443195
54negative regulation of lymphocyte mediated immunity (GO:0002707)3.75158349
55DNA deamination (GO:0045006)3.74112685
56tricarboxylic acid metabolic process (GO:0072350)3.74004969
57immunoglobulin mediated immune response (GO:0016064)3.72955891
58response to host immune response (GO:0052572)3.72568714
59response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.72568714
60branched-chain amino acid metabolic process (GO:0009081)3.71874398
61regulation of myeloid leukocyte mediated immunity (GO:0002886)3.70089106
62detection of biotic stimulus (GO:0009595)3.70002647
63glycine metabolic process (GO:0006544)3.62883410
64myeloid cell activation involved in immune response (GO:0002275)3.62057214
65NADH metabolic process (GO:0006734)3.60767166
66regulation of leukocyte degranulation (GO:0043300)3.59174764
67branched-chain amino acid catabolic process (GO:0009083)3.58835913
68translational elongation (GO:0006414)3.58347522
692-oxoglutarate metabolic process (GO:0006103)3.57749566
70regulation of gamma-delta T cell activation (GO:0046643)3.55939004
71regulation of sulfur metabolic process (GO:0042762)3.54045886
72drug transport (GO:0015893)3.52577898
73positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.51771845
74negative regulation of leukocyte mediated immunity (GO:0002704)3.50650490
75macrophage activation (GO:0042116)3.47795567
76regulation of regulated secretory pathway (GO:1903305)3.46864563
77phospholipid scrambling (GO:0017121)3.46668956
78maturation of SSU-rRNA (GO:0030490)3.46665807
79erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.46519017
80L-phenylalanine metabolic process (GO:0006558)3.46519017
81negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.44082137
82toxin transport (GO:1901998)3.43190465
83response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.40266677
84response to host (GO:0075136)3.40266677
85response to host defenses (GO:0052200)3.40266677
86regulation of mast cell activation involved in immune response (GO:0033006)3.39015267
87aminoglycoside antibiotic metabolic process (GO:0030647)3.37057403
88positive regulation of mast cell activation (GO:0033005)3.36783141
89positive thymic T cell selection (GO:0045059)3.34108396
90ribosomal small subunit biogenesis (GO:0042274)3.33756919
91response to interleukin-15 (GO:0070672)3.32697755
92serine family amino acid catabolic process (GO:0009071)3.32135770
93glyoxylate metabolic process (GO:0046487)3.30349115
94pantothenate metabolic process (GO:0015939)3.29307882
95L-phenylalanine catabolic process (GO:0006559)3.28936722
96erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.28936722
97telomere maintenance via telomerase (GO:0007004)3.28142535
98amino-acid betaine metabolic process (GO:0006577)3.28050609
99IMP biosynthetic process (GO:0006188)3.27685248
100defense response to protozoan (GO:0042832)3.25369560
101SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.23389618
102serine family amino acid metabolic process (GO:0009069)3.21532218
103negative regulation of toll-like receptor signaling pathway (GO:0034122)3.20702867
104DNA strand elongation involved in DNA replication (GO:0006271)3.20363873
105DNA strand elongation (GO:0022616)3.20346476
106nucleobase biosynthetic process (GO:0046112)3.18066995
107cotranslational protein targeting to membrane (GO:0006613)3.16481215
108telomere maintenance via semi-conservative replication (GO:0032201)3.16110735
109positive regulation of cellular amide metabolic process (GO:0034250)3.15366954
110negative regulation of phagocytosis (GO:0050765)3.14474265
111protein targeting to ER (GO:0045047)3.13948811
112fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.13057968
113IMP metabolic process (GO:0046040)3.12971864
114ribosome biogenesis (GO:0042254)3.11862530
115serine family amino acid biosynthetic process (GO:0009070)3.11703353
116regulation of superoxide anion generation (GO:0032928)3.11216258
117microglial cell activation (GO:0001774)3.10691974
118neutrophil mediated immunity (GO:0002446)3.09926838
119oxaloacetate metabolic process (GO:0006107)3.09889233
120leukocyte degranulation (GO:0043299)3.09757806
121folic acid metabolic process (GO:0046655)3.09409203
122fatty acid beta-oxidation (GO:0006635)3.08947146
123protein localization to endoplasmic reticulum (GO:0070972)3.07797306
124response to muramyl dipeptide (GO:0032495)3.06105957
125nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.05891987
126carnitine metabolic process (GO:0009437)3.03824732
127regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.03622456
128regulation of mast cell activation (GO:0033003)3.02471585
129positive regulation of mast cell activation involved in immune response (GO:0033008)3.01929781
130positive regulation of mast cell degranulation (GO:0043306)3.01929781
131positive regulation of regulated secretory pathway (GO:1903307)3.01924947
132negative regulation of type 2 immune response (GO:0002829)3.01830641
133secretory granule organization (GO:0033363)3.01368888
134purine nucleobase biosynthetic process (GO:0009113)3.01329522
135establishment of protein localization to endoplasmic reticulum (GO:0072599)2.99880768
136positive regulation of B cell differentiation (GO:0045579)2.99880012
137regulation of amyloid precursor protein catabolic process (GO:1902991)2.98156690
138peptidyl-threonine dephosphorylation (GO:0035970)2.97825865
139cysteine metabolic process (GO:0006534)2.97421714
140regulation of gamma-delta T cell differentiation (GO:0045586)2.97281997
141translational initiation (GO:0006413)2.96294396
142regulation of B cell differentiation (GO:0045577)2.95921775
143oxidative phosphorylation (GO:0006119)2.95674104
144pseudouridine synthesis (GO:0001522)2.95667993
145regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.95419992
146positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.94546521
147cellular response to interleukin-15 (GO:0071350)2.94534885
148negative regulation of innate immune response (GO:0045824)2.94151158
149response to interferon-alpha (GO:0035455)2.94119188
150ribonucleoprotein complex biogenesis (GO:0022613)2.93106390
151lipopolysaccharide-mediated signaling pathway (GO:0031663)2.93022465
152regulation of T cell tolerance induction (GO:0002664)2.92864897
153regulation of cellular amide metabolic process (GO:0034248)2.90524871
154fatty acid oxidation (GO:0019395)2.90253006
155fatty acid catabolic process (GO:0009062)2.89659578
156pteridine-containing compound biosynthetic process (GO:0042559)2.87995825
157formation of translation preinitiation complex (GO:0001731)2.87745798
158negative regulation of interleukin-6 production (GO:0032715)2.87475041
159phagosome maturation (GO:0090382)2.87074476
160positive regulation of Rap GTPase activity (GO:0032854)2.86637101
161response to interferon-beta (GO:0035456)2.86607261
162negative regulation of T-helper cell differentiation (GO:0045623)2.85629968
163negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.85629968
164positive regulation of Cdc42 GTPase activity (GO:0043089)2.85354977
165sulfur amino acid catabolic process (GO:0000098)2.84564027
166aromatic amino acid family catabolic process (GO:0009074)2.84270874
167antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.84068572
168NAD metabolic process (GO:0019674)2.83854721
169regulation of ARF protein signal transduction (GO:0032012)2.83157354
170regulation of antigen processing and presentation (GO:0002577)2.82866467
171lipid oxidation (GO:0034440)2.82625684
172positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.80361995
173interferon-gamma-mediated signaling pathway (GO:0060333)2.79093438
174antigen processing and presentation via MHC class Ib (GO:0002475)2.78986579
175biotin metabolic process (GO:0006768)2.78801569
176viral life cycle (GO:0019058)2.78719653
177cellular protein complex disassembly (GO:0043624)2.77330751
178metallo-sulfur cluster assembly (GO:0031163)2.77116759
179iron-sulfur cluster assembly (GO:0016226)2.77116759
180organic cation transport (GO:0015695)2.76624730
181cellular response to type I interferon (GO:0071357)2.75550326
182type I interferon signaling pathway (GO:0060337)2.75550326
183tRNA methylation (GO:0030488)2.73266979
184monocarboxylic acid catabolic process (GO:0072329)2.72844985
185positive regulation of type 2 immune response (GO:0002830)2.72833845
186regulation of type 2 immune response (GO:0002828)2.72609684
187response to type I interferon (GO:0034340)2.72333265
188response to protozoan (GO:0001562)2.70410869
189L-fucose catabolic process (GO:0042355)2.70084488
190fucose catabolic process (GO:0019317)2.70084488
191L-fucose metabolic process (GO:0042354)2.70084488
192tricarboxylic acid cycle (GO:0006099)2.69440278
193aerobic respiration (GO:0009060)2.69010660
194fructose metabolic process (GO:0006000)2.68742558
195response to thyroid hormone (GO:0097066)2.67638844
196heme transport (GO:0015886)2.65459314
197pentose-phosphate shunt (GO:0006098)2.64272604

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.65357154
2SCL_19346495_ChIP-Seq_HPC-7_Human3.51111859
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.45661194
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.27334020
5THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.14912029
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.10134350
7E2F7_22180533_ChIP-Seq_HELA_Human3.08709199
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.73754487
9KDM2B_26808549_Chip-Seq_SUP-B15_Human2.62905146
10LXR_22292898_ChIP-Seq_THP-1_Human2.59639774
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.49090214
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.48805329
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.47880902
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.46729430
15* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.39964927
16* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.39776511
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.35796329
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.29122035
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.25262794
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.21090755
21TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.21012103
22ELK3_25401928_ChIP-Seq_HUVEC_Human2.18070111
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.17535389
24KDM2B_26808549_Chip-Seq_DND41_Human2.15705003
25VDR_24763502_ChIP-Seq_THP-1_Human2.13705314
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.13661174
27GATA1_22025678_ChIP-Seq_K562_Human2.13348476
28EST1_17652178_ChIP-ChIP_JURKAT_Human2.10049649
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.09851655
30MYC_19030024_ChIP-ChIP_MESCs_Mouse2.09402732
31MYC_22102868_ChIP-Seq_BL_Human2.09006557
32RXR_22158963_ChIP-Seq_LIVER_Mouse2.08856943
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.06796584
34* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.01619375
35GABP_17652178_ChIP-ChIP_JURKAT_Human2.00015224
36SPI1_23127762_ChIP-Seq_K562_Human1.98274268
37MAF_26560356_Chip-Seq_TH1_Human1.96731786
38XRN2_22483619_ChIP-Seq_HELA_Human1.92552974
39STAT3_1855785_ChIP-Seq_MESCs_Mouse1.92148307
40IKZF1_21737484_ChIP-ChIP_HCT116_Human1.91982437
41PPARA_22158963_ChIP-Seq_LIVER_Mouse1.88760844
42IRF8_27001747_Chip-Seq_BMDM_Mouse1.84387033
43UTX_26944678_Chip-Seq_JUKART_Human1.83922531
44CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.82949843
45ERG_20887958_ChIP-Seq_HPC-7_Mouse1.82927387
46MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.82435080
47* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81486295
48MAF_26560356_Chip-Seq_TH2_Human1.81360339
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.78908372
50* SRF_21415370_ChIP-Seq_HL-1_Mouse1.78747442
51NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.77872590
52FOXP3_21729870_ChIP-Seq_TREG_Human1.77403042
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.77211198
54LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.74742327
55CREB1_15753290_ChIP-ChIP_HEK293T_Human1.74498508
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.69199726
57* RACK7_27058665_Chip-Seq_MCF-7_Human1.65699702
58BRD4_27068464_Chip-Seq_AML-cells_Mouse1.64004819
59CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.63923419
60STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.63257025
61RARG_19884340_ChIP-ChIP_MEFs_Mouse1.62918095
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.62870887
63KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.62195728
64EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61898611
65P68_20966046_ChIP-Seq_HELA_Human1.61440506
66VDR_23849224_ChIP-Seq_CD4+_Human1.60104947
67VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.60071730
68POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.59480187
69SA1_27219007_Chip-Seq_ERYTHROID_Human1.58905106
70KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.58879459
71BCOR_27268052_Chip-Seq_Bcells_Human1.54680894
72KDM2B_26808549_Chip-Seq_K562_Human1.53288402
73EGR1_23403033_ChIP-Seq_LIVER_Mouse1.53009712
74CTCF_27219007_Chip-Seq_ERYTHROID_Human1.52708509
75* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51936302
76CIITA_25753668_ChIP-Seq_RAJI_Human1.50211974
77* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50196752
78GABP_19822575_ChIP-Seq_HepG2_Human1.50036550
79MYB_21317192_ChIP-Seq_ERMYB_Mouse1.49116726
80NELFA_20434984_ChIP-Seq_ESCs_Mouse1.48785443
81TET1_21451524_ChIP-Seq_MESCs_Mouse1.48152120
82STAT4_19710469_ChIP-ChIP_TH1__Mouse1.47836831
83TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.47746202
84PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.46716244
85PU.1_20513432_ChIP-Seq_Bcells_Mouse1.46458752
86CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.46326614
87* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.46182705
88* VDR_21846776_ChIP-Seq_THP-1_Human1.45464965
89NANOG_18555785_ChIP-Seq_MESCs_Mouse1.45174332
90CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43967844
91CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.42958135
92PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42536419
93ELF1_20517297_ChIP-Seq_JURKAT_Human1.42110254
94KDM2B_26808549_Chip-Seq_JURKAT_Human1.41477526
95NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.40481182
96GATA1_22383799_ChIP-Seq_G1ME_Mouse1.39740761
97* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.39561845
98ZNF263_19887448_ChIP-Seq_K562_Human1.39466732
99EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.39000682
100SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.38674854
101ESR1_15608294_ChIP-ChIP_MCF-7_Human1.38260674
102SMC4_20622854_ChIP-Seq_HELA_Human1.37649717
103POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.37475513
104ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36882983
105DNAJC2_21179169_ChIP-ChIP_NT2_Human1.35843767
106PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35631573
107SPI1_23547873_ChIP-Seq_NB4_Human1.33980407
108ZFP281_18757296_ChIP-ChIP_E14_Mouse1.33958055
109SRY_22984422_ChIP-ChIP_TESTIS_Rat1.33875981
110HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.33269853
111SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32884232
112YY1_21170310_ChIP-Seq_MESCs_Mouse1.32683697
113PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.30089306
114TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29035855
115STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28047023
116GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27507594
117FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.26492071
118NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.24931642
119* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.24314506
120BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.24247926
121DCP1A_22483619_ChIP-Seq_HELA_Human1.23100571
122* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.22701617
123SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22239719
124RUNX_20019798_ChIP-Seq_JUKART_Human1.22097105
125CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21334242
126NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.20954404
127SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.20650451
128MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20403906
129SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.17348344
130SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16672180
131MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.16603780
132IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.16458655
133* GATA1_19941827_ChIP-Seq_MEL_Mouse1.16209784
134CTCF_26484167_Chip-Seq_Bcells_Mouse1.14770054
135GATA2_22383799_ChIP-Seq_G1ME_Mouse1.13285448
136MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.12501429
137FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.12283165
138ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11724305
139FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.10998070
140MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.10564708
141UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.09591579
142MYCN_18555785_ChIP-Seq_MESCs_Mouse1.09382145
143KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08706117
144SA1_27219007_Chip-Seq_Bcells_Human1.08439327
145CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.06253291
146MYB_26560356_Chip-Seq_TH1_Human1.05813711
147E2F4_17652178_ChIP-ChIP_JURKAT_Human1.05723955
148NOTCH1_21737748_ChIP-Seq_TLL_Human1.05514623
149CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03504092
150CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03281952
151E2F1_20622854_ChIP-Seq_HELA_Human1.03139814
152TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02339725
153PHF8_20622854_ChIP-Seq_HELA_Human1.00495702
154ERG_21242973_ChIP-ChIP_JURKAT_Human0.99708910
155* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99640839
156BCL6_27268052_Chip-Seq_Bcells_Human0.99626879
157NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.99376306
158RUNX1_22412390_ChIP-Seq_EML_Mouse0.98819595
159TCF7_22412390_ChIP-Seq_EML_Mouse0.98704881
160SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.98188590
161LXR_22158963_ChIP-Seq_LIVER_Mouse0.98004196
162NCOR1_26117541_ChIP-Seq_K562_Human0.97774601
163ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.97676458
164OCT4_19829295_ChIP-Seq_ESCs_Human0.97258244
165CREB1_26743006_Chip-Seq_LNCaP_Human0.96865797
166MYB_26560356_Chip-Seq_TH2_Human0.96839313
167CTCF_18555785_ChIP-Seq_MESCs_Mouse0.96362465
168* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.96021913
169IRF8_22096565_ChIP-ChIP_GC-B_Human0.94508441
170CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94392907

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to4.35827716
2MP0002139_abnormal_hepatobiliary_system3.75398081
3MP0005360_urolithiasis3.71634276
4MP0003303_peritoneal_inflammation3.61655776
5MP0003806_abnormal_nucleotide_metabolis3.49973425
6MP0002396_abnormal_hematopoietic_system3.46360533
7MP0003172_abnormal_lysosome_physiology3.36934489
8MP0004147_increased_porphyrin_level3.36251938
9MP0005365_abnormal_bile_salt3.23681661
10MP0005085_abnormal_gallbladder_physiolo3.18739419
11MP0001835_abnormal_antigen_presentation3.16141502
12MP0002419_abnormal_innate_immunity3.01482916
13MP0008260_abnormal_autophagy3.00244861
14MP0005387_immune_system_phenotype2.92876591
15MP0001790_abnormal_immune_system2.92876591
16MP0001800_abnormal_humoral_immune2.81516995
17MP0000685_abnormal_immune_system2.72603896
18MP0008875_abnormal_xenobiotic_pharmacok2.72029136
19MP0005000_abnormal_immune_tolerance2.70175538
20MP0004808_abnormal_hematopoietic_stem2.69998807
21MP0005332_abnormal_amino_acid2.61856375
22MP0009840_abnormal_foam_cell2.60741928
23MP0006036_abnormal_mitochondrial_physio2.54878833
24MP0002420_abnormal_adaptive_immunity2.46041597
25MP0002723_abnormal_immune_serum2.45033930
26MP0002452_abnormal_antigen_presenting2.44539278
27MP0005671_abnormal_response_to2.42173485
28MP0001819_abnormal_immune_cell2.41069780
29MP0001545_abnormal_hematopoietic_system2.14003251
30MP0005397_hematopoietic_system_phenotyp2.14003251
31MP0006082_CNS_inflammation2.10753182
32MP0005451_abnormal_body_composition2.08405923
33MP0003656_abnormal_erythrocyte_physiolo2.06587970
34MP0003693_abnormal_embryo_hatching2.04219384
35MP0001533_abnormal_skeleton_physiology2.02148698
36MP0002132_abnormal_respiratory_system1.97005373
37MP0004381_abnormal_hair_follicle1.91927797
38MP0002148_abnormal_hypersensitivity_rea1.90893740
39MP0005319_abnormal_enzyme/_coenzyme1.88244053
40MP0010329_abnormal_lipoprotein_level1.83882628
41MP0000747_muscle_weakness1.83766663
42MP0001986_abnormal_taste_sensitivity1.83573665
43MP0003075_altered_response_to1.79631431
44MP0001764_abnormal_homeostasis1.78761045
45MP0003183_abnormal_peptide_metabolism1.77195281
46MP0002405_respiratory_system_inflammati1.73778061
47MP0002089_abnormal_postnatal_growth/wei1.73669643
48MP0003763_abnormal_thymus_physiology1.70853990
49MP0005464_abnormal_platelet_physiology1.70159875
50MP0005075_abnormal_melanosome_morpholog1.68472674
51MP0004859_abnormal_synaptic_plasticity1.63754675
52MP0009697_abnormal_copulation1.63270125
53MP0006054_spinal_hemorrhage1.62753659
54MP0009643_abnormal_urine_homeostasis1.61614252
55MP0010094_abnormal_chromosome_stability1.61324115
56MP0000465_gastrointestinal_hemorrhage1.58860715
57MP0003329_amyloid_beta_deposits1.56430570
58MP0008057_abnormal_DNA_replication1.54813499
59MP0001845_abnormal_inflammatory_respons1.54380001
60MP0003690_abnormal_glial_cell1.51179763
61MP0005584_abnormal_enzyme/coenzyme_acti1.49820800
62MP0003705_abnormal_hypodermis_morpholog1.48368898
63MP0004947_skin_inflammation1.47265178
64MP0003191_abnormal_cellular_cholesterol1.46045027
65MP0004019_abnormal_vitamin_homeostasis1.46010430
66MP0003186_abnormal_redox_activity1.45249511
67MP0004084_abnormal_cardiac_muscle1.45033500
68MP0000598_abnormal_liver_morphology1.45019706
69MP0000604_amyloidosis1.44553088
70MP0003300_gastrointestinal_ulcer1.44056775
71MP0004957_abnormal_blastocyst_morpholog1.41267622
72MP0000858_altered_metastatic_potential1.37815937
73MP0006035_abnormal_mitochondrial_morpho1.35719183
74MP0005058_abnormal_lysosome_morphology1.35558271
75MP0000490_abnormal_crypts_of1.34829271
76MP0000689_abnormal_spleen_morphology1.33064187
77MP0004130_abnormal_muscle_cell1.32095131
78MP0003111_abnormal_nucleus_morphology1.31543954
79MP0003828_pulmonary_edema1.29492004
80MP0000609_abnormal_liver_physiology1.28619088
81MP0003866_abnormal_defecation1.26368415
82MP0004510_myositis1.25481543
83MP0003077_abnormal_cell_cycle1.24984899
84MP0000015_abnormal_ear_pigmentation1.24797032
85MP0005310_abnormal_salivary_gland1.24452496
86MP0005166_decreased_susceptibility_to1.23418879
87MP0010155_abnormal_intestine_physiology1.22214847
88MP0003943_abnormal_hepatobiliary_system1.22149509
89MP0002095_abnormal_skin_pigmentation1.20872239
90MP0004858_abnormal_nervous_system1.19480959
91MP0005174_abnormal_tail_pigmentation1.19187374
92MP0002722_abnormal_immune_system1.17557027
93MP0005636_abnormal_mineral_homeostasis1.17177361
94MP0002118_abnormal_lipid_homeostasis1.16394282
95MP0000703_abnormal_thymus_morphology1.14987544
96MP0004043_abnormal_pH_regulation1.13766172
97MP0009764_decreased_sensitivity_to1.09020900
98MP0003868_abnormal_feces_composition1.08785401
99MP0002398_abnormal_bone_marrow1.08619952
100MP0003123_paternal_imprinting1.08496394
101MP0008007_abnormal_cellular_replicative1.08445791
102MP0002277_abnormal_respiratory_mucosa1.08349700
103MP0002269_muscular_atrophy1.08254675
104MP0003221_abnormal_cardiomyocyte_apopto1.08224850
105MP0008469_abnormal_protein_level1.07762083
106MP0009278_abnormal_bone_marrow1.07676911
107MP0001348_abnormal_lacrimal_gland1.07050885
108MP0002009_preneoplasia1.04807090
109MP0002998_abnormal_bone_remodeling1.04591753
110MP0004883_abnormal_blood_vessel1.04491716
111MP0005266_abnormal_metabolism1.04194364
112MP0008874_decreased_physiological_sensi1.03378068
113MP0003567_abnormal_fetal_cardiomyocyte1.02796260
114MP0002837_dystrophic_cardiac_calcinosis1.00824686
115MP0001849_ear_inflammation0.99999166
116MP0006292_abnormal_olfactory_placode0.98963493
117MP0003638_abnormal_response/metabolism_0.97556676
118MP0003724_increased_susceptibility_to0.96470978
119MP0000358_abnormal_cell_content/0.95375519
120MP0005330_cardiomyopathy0.94895125
121MP0002136_abnormal_kidney_physiology0.94593976
122MP0002429_abnormal_blood_cell0.93687510
123MP0003879_abnormal_hair_cell0.93212542
124MP0009765_abnormal_xenobiotic_induced0.93009794
125MP0009785_altered_susceptibility_to0.92253086
126MP0001851_eye_inflammation0.91182676
127MP0001756_abnormal_urination0.90249237
128MP0005025_abnormal_response_to0.90016743
129MP0002166_altered_tumor_susceptibility0.89216274
130MP0008873_increased_physiological_sensi0.88358253
131MP0001666_abnormal_nutrient_absorption0.87570476
132MP0008058_abnormal_DNA_repair0.85852306
133MP0003646_muscle_fatigue0.84799019
134MP0009333_abnormal_splenocyte_physiolog0.83769430
135MP0005377_hearing/vestibular/ear_phenot0.83700527
136MP0003878_abnormal_ear_physiology0.83700527
137MP0000920_abnormal_myelination0.83433197
138MP0000343_altered_response_to0.83258934
139MP0005390_skeleton_phenotype0.82971125
140MP0001853_heart_inflammation0.82553132
141MP0008004_abnormal_stomach_pH0.82498992
142MP0002933_joint_inflammation0.82246472
143MP0009642_abnormal_blood_homeostasis0.81868771
144MP0001663_abnormal_digestive_system0.81859565
145MP0002653_abnormal_ependyma_morphology0.81462082
146MP0005084_abnormal_gallbladder_morpholo0.81054437
147MP0001765_abnormal_ion_homeostasis0.80633104
148MP0000751_myopathy0.79723407
149MP0000516_abnormal_urinary_system0.79395406
150MP0005367_renal/urinary_system_phenotyp0.79395406
151MP0004264_abnormal_extraembryonic_tissu0.79199396
152MP0009763_increased_sensitivity_to0.78789950
153MP0000313_abnormal_cell_death0.78489495
154MP0004142_abnormal_muscle_tone0.76368132
155MP0001958_emphysema0.75939693
156MP0000716_abnormal_immune_system0.75549561
157MP0002019_abnormal_tumor_incidence0.75115611
158MP0002080_prenatal_lethality0.73897646
159MP0005083_abnormal_biliary_tract0.73077421
160MP0010352_gastrointestinal_tract_polyps0.71246797
161MP0004133_heterotaxia0.71077037
162MP0005164_abnormal_response_to0.66329386
163MP0002064_seizures0.64806890
164MP0003566_abnormal_cell_adhesion0.62992426
165MP0005409_darkened_coat_color0.62837108
166MP0008569_lethality_at_weaning0.62807779
167MP0003448_altered_tumor_morphology0.60172733
168MP0001873_stomach_inflammation0.60004658
169MP0005167_abnormal_blood-brain_barrier0.58916476
170MP0005423_abnormal_somatic_nervous0.58063865
171MP0003635_abnormal_synaptic_transmissio0.58028275
172MP0003795_abnormal_bone_structure0.57849900
173MP0000767_abnormal_smooth_muscle0.54913216

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.23464684
2Recurrent bacterial skin infections (HP:0005406)5.57983707
3Recurrent abscess formation (HP:0002722)5.55628006
4Abnormality of macrophages (HP:0004311)5.40664625
5Aplastic anemia (HP:0001915)4.74438027
6Thrombocytosis (HP:0001894)4.70735647
7Recurrent gram-negative bacterial infections (HP:0005420)4.57754930
8Hyperglycinuria (HP:0003108)4.50704818
9Obstructive lung disease (HP:0006536)4.44813086
10Chronic obstructive pulmonary disease (HP:0006510)4.44813086
11Abnormality of the heme biosynthetic pathway (HP:0010472)4.32662936
12Mediastinal lymphadenopathy (HP:0100721)4.28474243
13Orchitis (HP:0100796)4.27032753
14Abnormality of serine family amino acid metabolism (HP:0010894)4.13606475
15Abnormality of glycine metabolism (HP:0010895)4.13606475
16Hyperglycinemia (HP:0002154)3.96103823
17Retrobulbar optic neuritis (HP:0100654)3.86640732
18Optic neuritis (HP:0100653)3.86640732
19Gout (HP:0001997)3.85821690
20Gastrointestinal infarctions (HP:0005244)3.80788638
21Stomatitis (HP:0010280)3.80426591
22Abnormality of aromatic amino acid family metabolism (HP:0004338)3.79933893
23Meningitis (HP:0001287)3.75081088
24Cellulitis (HP:0100658)3.68014284
25Recurrent skin infections (HP:0001581)3.63553950
26Tinnitus (HP:0000360)3.60669834
27Generalized aminoaciduria (HP:0002909)3.57153899
28Spontaneous hematomas (HP:0007420)3.50229726
29Recurrent fungal infections (HP:0002841)3.44651606
30Abnormality of fatty-acid metabolism (HP:0004359)3.42477197
31Abnormality of cells of the erythroid lineage (HP:0012130)3.36355947
32Abnormal number of erythroid precursors (HP:0012131)3.35522611
33Abnormal delayed hypersensitivity skin test (HP:0002963)3.25127476
34Gastrointestinal stroma tumor (HP:0100723)3.23540686
35Urticaria (HP:0001025)3.22793302
36Increased IgE level (HP:0003212)3.16652892
37Gingivitis (HP:0000230)3.14503684
38Chronic mucocutaneous candidiasis (HP:0002728)3.07222302
39Recurrent cutaneous fungal infections (HP:0011370)3.07222302
40Vasculitis (HP:0002633)3.05229383
41Ketosis (HP:0001946)3.03818906
42Increased cerebral lipofuscin (HP:0011813)3.03525124
43Supranuclear gaze palsy (HP:0000605)3.01088419
44Encephalitis (HP:0002383)2.96885154
45Abnormality of serum amino acid levels (HP:0003112)2.95864066
46Gastrointestinal inflammation (HP:0004386)2.95058600
47Abnormality of glycolipid metabolism (HP:0010969)2.90944725
48Abnormality of liposaccharide metabolism (HP:0010968)2.90944725
49Abnormality of glycosphingolipid metabolism (HP:0004343)2.90944725
50Hypochromic anemia (HP:0001931)2.90459757
51Intrahepatic cholestasis (HP:0001406)2.89755786
52Prolonged bleeding time (HP:0003010)2.87418904
53Hyperammonemia (HP:0001987)2.85607637
54Pancytopenia (HP:0001876)2.85550596
55Amaurosis fugax (HP:0100576)2.84938558
56Posterior subcapsular cataract (HP:0007787)2.84888226
57Inflammation of the large intestine (HP:0002037)2.83740037
58Elevated erythrocyte sedimentation rate (HP:0003565)2.81551852
59Reduced antithrombin III activity (HP:0001976)2.76440976
60Epistaxis (HP:0000421)2.76261795
61Dicarboxylic aciduria (HP:0003215)2.74680575
62Abnormality of dicarboxylic acid metabolism (HP:0010995)2.74680575
63Episodic fever (HP:0001954)2.74008494
64Hypochromic microcytic anemia (HP:0004840)2.73240040
65Reticulocytopenia (HP:0001896)2.70216097
66Delayed CNS myelination (HP:0002188)2.70205114
67Keratoconjunctivitis sicca (HP:0001097)2.69038839
68Type I transferrin isoform profile (HP:0003642)2.68144583
69Lymphopenia (HP:0001888)2.67752509
70Microretrognathia (HP:0000308)2.65783830
71Hepatic necrosis (HP:0002605)2.63958299
72Ketoacidosis (HP:0001993)2.63561263
73Colitis (HP:0002583)2.59799506
74Increased neuronal autofluorescent lipopigment (HP:0002074)2.56878123
75Chest pain (HP:0100749)2.54122356
76Abnormal platelet function (HP:0011869)2.53752487
77Impaired platelet aggregation (HP:0003540)2.53752487
78Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.49777502
79Petechiae (HP:0000967)2.49712748
80Keratoconjunctivitis (HP:0001096)2.49463320
81Amyloidosis (HP:0011034)2.48047399
82Fatigue (HP:0012378)2.46498221
83Proximal tubulopathy (HP:0000114)2.46339915
84Spontaneous abortion (HP:0005268)2.44788052
85Osteomyelitis (HP:0002754)2.44712505
86Pustule (HP:0200039)2.42341562
87Abnormality of monocarboxylic acid metabolism (HP:0010996)2.41737540
88Loss of speech (HP:0002371)2.41168566
89Hemoptysis (HP:0002105)2.40879725
90Neuronal loss in central nervous system (HP:0002529)2.40740487
91Agammaglobulinemia (HP:0004432)2.39918255
92Abnormality of cells of the lymphoid lineage (HP:0012140)2.39629128
93Microvesicular hepatic steatosis (HP:0001414)2.38898841
94Abnormality of alanine metabolism (HP:0010916)2.36144578
95Hyperalaninemia (HP:0003348)2.36144578
96Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.36144578
97Pulmonary infiltrates (HP:0002113)2.34753581
98Sepsis (HP:0100806)2.31844715
99IgM deficiency (HP:0002850)2.30157863
100Hypobetalipoproteinemia (HP:0003563)2.29374520
101Gingival bleeding (HP:0000225)2.28511243
102Limb hypertonia (HP:0002509)2.26569439
103Restrictive lung disease (HP:0002091)2.26314647
104Hepatosplenomegaly (HP:0001433)2.25093793
105Metabolic acidosis (HP:0001942)2.24471807
106Hepatocellular necrosis (HP:0001404)2.23584978
107Slow saccadic eye movements (HP:0000514)2.22515641
108Abnormality of aspartate family amino acid metabolism (HP:0010899)2.22131849
109Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.21798390
110Neonatal onset (HP:0003623)2.20974071
111Emphysema (HP:0002097)2.20789173
112Abnormality of purine metabolism (HP:0004352)2.20769669
113Hyperbilirubinemia (HP:0002904)2.20668110
114Peritonitis (HP:0002586)2.20030035
115Anorexia (HP:0002039)2.18972935
116Pulmonary embolism (HP:0002204)2.18636669
117Dysostosis multiplex (HP:0000943)2.17038979
118Oral leukoplakia (HP:0002745)2.16594769
119Thrombophlebitis (HP:0004418)2.15906984
120Mutism (HP:0002300)2.15595389
121Lethargy (HP:0001254)2.14561102
122Hyperuricemia (HP:0002149)2.14329419
123Increased purine levels (HP:0004368)2.14329419
124Hypermelanotic macule (HP:0001034)2.14106694
125Xanthomatosis (HP:0000991)2.13677057
126Menorrhagia (HP:0000132)2.13306428
127Abnormality of urine glucose concentration (HP:0011016)2.12703954
128Glycosuria (HP:0003076)2.12703954
129Increased muscle lipid content (HP:0009058)2.11732664
130Verrucae (HP:0200043)2.11163145
131Papilloma (HP:0012740)2.11163145
132Abnormality of nucleobase metabolism (HP:0010932)2.10509852
133Obstructive sleep apnea (HP:0002870)2.10184721
134Hypoglycemic coma (HP:0001325)2.08440785
135Increased intramyocellular lipid droplets (HP:0012240)2.07349349
136Segmental peripheral demyelination/remyelination (HP:0003481)2.06893047
137Recurrent viral infections (HP:0004429)2.05911651
138Purpura (HP:0000979)2.04625902
139Late onset (HP:0003584)2.04318821
140Macrocytic anemia (HP:0001972)2.03548127
141Biconcave vertebral bodies (HP:0004586)2.03476665
142Progressive muscle weakness (HP:0003323)2.03342573
143Panhypogammaglobulinemia (HP:0003139)2.03333959
144Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.03039447
145Hyperlipoproteinemia (HP:0010980)2.02582275
146Lactic acidosis (HP:0003128)2.01375734
147Myositis (HP:0100614)2.01169558
148Myelodysplasia (HP:0002863)2.00949772
149Ankle clonus (HP:0011448)2.00008050
150Metaphyseal cupping (HP:0003021)1.99963377
151Colon cancer (HP:0003003)1.98374680
152Increased serum ferritin (HP:0003281)1.97798788
153Abnormality of the peritoneum (HP:0002585)1.97069224
154Neurodegeneration (HP:0002180)1.96769178
155Spastic diplegia (HP:0001264)1.96704194
156Abnormality of the intrinsic pathway (HP:0010989)1.94644267
157Hypertensive crisis (HP:0100735)1.92059240
158Abnormality of glutamine family amino acid metabolism (HP:0010902)1.90479825
159Abnormality of pyrimidine metabolism (HP:0004353)1.89990219
160Ragged-red muscle fibers (HP:0003200)1.88144534
161Abnormal protein glycosylation (HP:0012346)1.87870024
162Abnormal glycosylation (HP:0012345)1.87870024
163Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.87870024
164Abnormal protein N-linked glycosylation (HP:0012347)1.87870024
165Irritability (HP:0000737)1.87812925
166Birth length less than 3rd percentile (HP:0003561)1.87576555
167Microcytic anemia (HP:0001935)1.87541744
168Esophageal neoplasm (HP:0100751)1.87126318
169Neoplasm of head and neck (HP:0012288)1.87126318
170Vomiting (HP:0002013)1.87068504
171Neoplasm of the peripheral nervous system (HP:0100007)1.86564881
172Myoglobinuria (HP:0002913)1.86203431
173Abnormality of mucopolysaccharide metabolism (HP:0011020)1.85829222
174Abnormality of polysaccharide metabolism (HP:0011012)1.85829222
175Abnormality of glycosaminoglycan metabolism (HP:0004371)1.85829222
176Increased IgM level (HP:0003496)1.85553135
177Visual hallucinations (HP:0002367)1.85348100
178Ocular albinism (HP:0001107)1.84349552
179Recurrent lower respiratory tract infections (HP:0002783)1.83421361
180Chronic otitis media (HP:0000389)1.83277893
181Skin ulcer (HP:0200042)1.82152965
182Premature loss of primary teeth (HP:0006323)1.80795393
183Acne (HP:0001061)1.80058344
184Anomalous pulmonary venous return (HP:0010772)1.79848045
185Recurrent pneumonia (HP:0006532)1.79401673
186Atrioventricular block (HP:0001678)1.79284118
187Neoplasm of the oral cavity (HP:0100649)1.79281169
188Arterial thrombosis (HP:0004420)1.79168274
189Neurofibrillary tangles (HP:0002185)1.78573057
190Abnormality of the endocardium (HP:0004306)1.78086279
191Recurrent sinusitis (HP:0011108)1.77747715

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.92472893
2RIPK44.44112108
3ERN13.56740615
4EEF2K3.23522087
5PKN23.19532206
6TGFBR13.17630588
7NME22.99053000
8IRAK42.85611017
9MAP2K32.80874932
10FLT32.73552455
11MATK2.67555976
12KIT2.54215294
13CDK192.54124992
14ACVR1B2.48941313
15MAP3K112.47975591
16TYK22.36421660
17WEE12.30801446
18STK162.28509401
19NEK12.16736315
20PRPF4B2.11328561
21CSK2.06268243
22FES2.02298749
23RPS6KB21.91263231
24MAP3K31.90996426
25BUB11.79265648
26TAOK11.78586551
27MAP4K11.77561594
28SIK31.73086184
29TIE11.72177468
30MAP3K121.71399518
31KSR21.67364286
32PASK1.64739418
33SIK11.60590508
34EPHB11.59210231
35PIM21.57714870
36MAP3K61.57515259
37PDK31.57158283
38PDK41.57158283
39TSSK61.55878133
40FGR1.51649230
41MARK21.51397977
42TESK21.46984301
43BTK1.46872392
44MAP2K61.46670070
45SIK21.44711887
46ARAF1.39809083
47SMG11.33425491
48HCK1.31812129
49PRKD21.31784768
50PAK41.27714474
51PINK11.27555956
52PIM11.26950738
53MAP3K11.26016314
54MUSK1.23307806
55TRIB31.21428485
56TEC1.20917242
57MYLK1.19586534
58CSF1R1.16979930
59WNK31.16312960
60PTK61.14524195
61PDPK11.12678495
62MAPKAPK31.10533467
63CAMKK11.07812101
64DAPK21.07554403
65TNIK1.07048368
66CDC42BPA1.03772183
67CCNB11.03003619
68PDK10.99054983
69MAPKAPK50.95369151
70MAPK120.95248855
71DAPK10.93543455
72JAK30.93456483
73MARK30.92500590
74OXSR10.92457717
75ICK0.92404851
76TBK10.90859298
77LRRK20.89832327
78JAK20.89778151
79PIK3CG0.89166895
80DYRK30.88813390
81IRAK20.88018816
82PAK60.84824991
83MKNK10.81880562
84TAOK20.78007463
85NEK20.77717399
86DYRK1B0.77689512
87MAP3K130.76698715
88IRAK30.75638631
89ZAP700.74918058
90PLK10.72788042
91MAP3K140.71912652
92TRPM70.69099021
93TTN0.69039484
94MAP3K90.68412904
95CSNK1G30.67844058
96MAPK40.67276887
97FGFR40.66313032
98ITK0.65766494
99CDK70.65549896
100FYN0.65257907
101MAP2K40.65038869
102TGFBR20.64615861
103MAPK110.64542056
104BRAF0.64325538
105STK100.62748655
106RAF10.61980020
107PTK2B0.61940548
108MAP3K80.61798790
109SGK30.60697907
110TAOK30.59070763
111PRKD30.58403882
112JAK10.58196088
113ALK0.57990972
114PRKCH0.57922863
115TXK0.57622893
116MAP3K100.56247970
117CSNK2A20.54734195
118KSR10.53894594
119ATR0.53452075
120SYK0.52077113
121MKNK20.51640647
122BMX0.50963726
123STK110.49811419
124NTRK30.49607229
125TESK10.48672487
126VRK10.48410768
127RPS6KA60.47397733
128YES10.47211956
129MAP3K70.47000694
130STK380.45426330
131BRSK20.43240544
132RPS6KA20.42527058
133PRKAA20.42455431
134MAP2K70.42110381
135AKT20.41547626
136BLK0.41245426
137CDK40.41232903
138CDK80.40710276
139PRKCQ0.39668882
140IKBKB0.39513463
141MAPK70.39419377
142PRKD10.39291143
143PRKCZ0.39014101
144KDR0.38562643
145RPS6KC10.38331338
146RPS6KL10.38331338
147LYN0.38137771
148CAMKK20.37972921
149PRKG20.37848093
150CAMK10.36226301
151LCK0.35949903
152PHKG20.34604187
153PHKG10.34604187
154PRKCI0.34223821
155TNK20.33525594
156RIPK10.33295823
157ILK0.32666975
158DAPK30.32314105
159RPS6KA40.31784015
160ZAK0.31697825
161CSNK1G20.31020669
162RET0.30900461
163IKBKE0.30401379
164MAP2K20.29253575
165GRK60.27931410

Predicted pathways (KEGG)

RankGene SetZ-score
12-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.06223310
2Ribosome_Homo sapiens_hsa030103.00854914
3DNA replication_Homo sapiens_hsa030302.90114575
4Osteoclast differentiation_Homo sapiens_hsa043802.77900256
5B cell receptor signaling pathway_Homo sapiens_hsa046622.74315625
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.68027562
7Mismatch repair_Homo sapiens_hsa034302.66471867
8Leishmaniasis_Homo sapiens_hsa051402.65141604
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.58979510
10Staphylococcus aureus infection_Homo sapiens_hsa051502.46732097
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.45366008
12Sulfur relay system_Homo sapiens_hsa041222.42507771
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.40343983
14Folate biosynthesis_Homo sapiens_hsa007902.37719272
15Fatty acid degradation_Homo sapiens_hsa000712.26225744
16Tuberculosis_Homo sapiens_hsa051522.18627144
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.16980770
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.13461065
19Pentose phosphate pathway_Homo sapiens_hsa000302.12054538
20Primary bile acid biosynthesis_Homo sapiens_hsa001202.10948073
21Pentose and glucuronate interconversions_Homo sapiens_hsa000402.03907271
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.02301982
23Propanoate metabolism_Homo sapiens_hsa006402.00267627
24Biosynthesis of amino acids_Homo sapiens_hsa012301.99402502
25Allograft rejection_Homo sapiens_hsa053301.96413450
26Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.95745910
27Carbon metabolism_Homo sapiens_hsa012001.94380329
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.93418926
29RNA polymerase_Homo sapiens_hsa030201.90940336
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.90543561
31Graft-versus-host disease_Homo sapiens_hsa053321.89657266
32Autoimmune thyroid disease_Homo sapiens_hsa053201.87186306
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.86489704
34Butanoate metabolism_Homo sapiens_hsa006501.85192693
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.79446508
36Peroxisome_Homo sapiens_hsa041461.78873593
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.77582389
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.73217969
39Primary immunodeficiency_Homo sapiens_hsa053401.72752226
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.71278967
41Fatty acid elongation_Homo sapiens_hsa000621.69410363
42Pyrimidine metabolism_Homo sapiens_hsa002401.67740839
43Phagosome_Homo sapiens_hsa041451.61207384
44Fatty acid metabolism_Homo sapiens_hsa012121.59921056
45beta-Alanine metabolism_Homo sapiens_hsa004101.56898156
46Tryptophan metabolism_Homo sapiens_hsa003801.54074530
47Chemokine signaling pathway_Homo sapiens_hsa040621.53595064
48Type I diabetes mellitus_Homo sapiens_hsa049401.53220850
49VEGF signaling pathway_Homo sapiens_hsa043701.52790795
50Pyruvate metabolism_Homo sapiens_hsa006201.49992414
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.42024535
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.41915363
53Toxoplasmosis_Homo sapiens_hsa051451.37344968
54Viral myocarditis_Homo sapiens_hsa054161.36012249
55Malaria_Homo sapiens_hsa051441.32252046
56Lysosome_Homo sapiens_hsa041421.31821353
57Synaptic vesicle cycle_Homo sapiens_hsa047211.31200466
58Cyanoamino acid metabolism_Homo sapiens_hsa004601.30998434
59T cell receptor signaling pathway_Homo sapiens_hsa046601.28532663
60Hematopoietic cell lineage_Homo sapiens_hsa046401.27842570
61Starch and sucrose metabolism_Homo sapiens_hsa005001.27339313
62Non-small cell lung cancer_Homo sapiens_hsa052231.26704763
63Antigen processing and presentation_Homo sapiens_hsa046121.25485138
64Notch signaling pathway_Homo sapiens_hsa043301.24873490
65Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.23061545
66Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.18886557
67Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.18861375
68NOD-like receptor signaling pathway_Homo sapiens_hsa046211.17176970
69Vitamin B6 metabolism_Homo sapiens_hsa007501.16268680
70Influenza A_Homo sapiens_hsa051641.15770348
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.15697238
72Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.15556321
73Endocytosis_Homo sapiens_hsa041441.14576564
74Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.13606736
75Arginine biosynthesis_Homo sapiens_hsa002201.13492361
76Collecting duct acid secretion_Homo sapiens_hsa049661.13244367
77NF-kappa B signaling pathway_Homo sapiens_hsa040641.09557625
78Fructose and mannose metabolism_Homo sapiens_hsa000511.09100990
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.08997192
80Leukocyte transendothelial migration_Homo sapiens_hsa046701.08794583
81Glycosaminoglycan degradation_Homo sapiens_hsa005311.07659790
82GnRH signaling pathway_Homo sapiens_hsa049121.07153209
83Galactose metabolism_Homo sapiens_hsa000521.06584811
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.06178374
85Selenocompound metabolism_Homo sapiens_hsa004501.05943141
86Neurotrophin signaling pathway_Homo sapiens_hsa047221.05779471
87Nucleotide excision repair_Homo sapiens_hsa034201.04227726
88Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03246442
89Legionellosis_Homo sapiens_hsa051341.03230863
90Measles_Homo sapiens_hsa051621.02605666
91Phospholipase D signaling pathway_Homo sapiens_hsa040721.01850619
92RNA degradation_Homo sapiens_hsa030181.00656724
93Salmonella infection_Homo sapiens_hsa051320.99907449
94Rheumatoid arthritis_Homo sapiens_hsa053230.99492693
95One carbon pool by folate_Homo sapiens_hsa006700.99130416
96Histidine metabolism_Homo sapiens_hsa003400.98908790
97Spliceosome_Homo sapiens_hsa030400.98725470
98Caffeine metabolism_Homo sapiens_hsa002320.98249943
99Vitamin digestion and absorption_Homo sapiens_hsa049770.97949786
100Base excision repair_Homo sapiens_hsa034100.97202417
101Apoptosis_Homo sapiens_hsa042100.93998330
102Shigellosis_Homo sapiens_hsa051310.93750067
103TNF signaling pathway_Homo sapiens_hsa046680.91613255
104Long-term potentiation_Homo sapiens_hsa047200.91593955
105Arginine and proline metabolism_Homo sapiens_hsa003300.91056508
106Hepatitis B_Homo sapiens_hsa051610.90686438
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.89649840
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89573035
109Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89418390
110RNA transport_Homo sapiens_hsa030130.89224130
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.87377856
112Asthma_Homo sapiens_hsa053100.87324130
113Nitrogen metabolism_Homo sapiens_hsa009100.86853775
114African trypanosomiasis_Homo sapiens_hsa051430.86131618
115Chronic myeloid leukemia_Homo sapiens_hsa052200.85640665
116Intestinal immune network for IgA production_Homo sapiens_hsa046720.84151225
117Pertussis_Homo sapiens_hsa051330.83367476
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82536565
119Glutathione metabolism_Homo sapiens_hsa004800.81160694
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80835809
121Renal cell carcinoma_Homo sapiens_hsa052110.80594504
122Hepatitis C_Homo sapiens_hsa051600.79877852
123Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79270675
124Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77639057
125Pancreatic cancer_Homo sapiens_hsa052120.76674667
126PPAR signaling pathway_Homo sapiens_hsa033200.76642761
127Purine metabolism_Homo sapiens_hsa002300.75949201
128Inositol phosphate metabolism_Homo sapiens_hsa005620.75129822
129Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74944378
130Vibrio cholerae infection_Homo sapiens_hsa051100.73344231
131Metabolic pathways_Homo sapiens_hsa011000.72661924
132ABC transporters_Homo sapiens_hsa020100.72228273
133Choline metabolism in cancer_Homo sapiens_hsa052310.71395510
134Endometrial cancer_Homo sapiens_hsa052130.71293792
135Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71127493
136Epstein-Barr virus infection_Homo sapiens_hsa051690.69504494
137Proteasome_Homo sapiens_hsa030500.67801511
138AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67493640
139ErbB signaling pathway_Homo sapiens_hsa040120.67365827
140Rap1 signaling pathway_Homo sapiens_hsa040150.67022195
141Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65327195
142HIF-1 signaling pathway_Homo sapiens_hsa040660.65243545
143Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65169157
144Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.64842139
145Jak-STAT signaling pathway_Homo sapiens_hsa046300.63760727
146Estrogen signaling pathway_Homo sapiens_hsa049150.63396951
147Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62992721
148Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62409824
149Phenylalanine metabolism_Homo sapiens_hsa003600.62144854
150Glioma_Homo sapiens_hsa052140.59271163
151MAPK signaling pathway_Homo sapiens_hsa040100.58015604
152Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57602569
153mTOR signaling pathway_Homo sapiens_hsa041500.55768111
154Bile secretion_Homo sapiens_hsa049760.55634470
155Complement and coagulation cascades_Homo sapiens_hsa046100.55446175
156Chemical carcinogenesis_Homo sapiens_hsa052040.55331379
157Gastric acid secretion_Homo sapiens_hsa049710.55255793
158Maturity onset diabetes of the young_Homo sapiens_hsa049500.55031611
159Viral carcinogenesis_Homo sapiens_hsa052030.54214384
160HTLV-I infection_Homo sapiens_hsa051660.52696017
161Glycerophospholipid metabolism_Homo sapiens_hsa005640.51752072
162Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49892882
163Prolactin signaling pathway_Homo sapiens_hsa049170.49057279
164Insulin signaling pathway_Homo sapiens_hsa049100.48779399
165Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47765231
166Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47387428
167Lysine degradation_Homo sapiens_hsa003100.46679444
168Colorectal cancer_Homo sapiens_hsa052100.44987739
169Prion diseases_Homo sapiens_hsa050200.44435969
170N-Glycan biosynthesis_Homo sapiens_hsa005100.43973057
171Parkinsons disease_Homo sapiens_hsa050120.43629130
172Cell cycle_Homo sapiens_hsa041100.42541115
173Homologous recombination_Homo sapiens_hsa034400.39920851
174Central carbon metabolism in cancer_Homo sapiens_hsa052300.37901267
175Acute myeloid leukemia_Homo sapiens_hsa052210.36935502
176Herpes simplex infection_Homo sapiens_hsa051680.33472377
177Regulation of autophagy_Homo sapiens_hsa041400.33243585
178Glycerolipid metabolism_Homo sapiens_hsa005610.33001075
179RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.32360761
180Steroid hormone biosynthesis_Homo sapiens_hsa001400.31936190
181Retinol metabolism_Homo sapiens_hsa008300.31458666
182Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28749477
183Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.27107914
184Platelet activation_Homo sapiens_hsa046110.24124570
185Sulfur metabolism_Homo sapiens_hsa009200.21899219
186Other glycan degradation_Homo sapiens_hsa005110.21193956
187Arachidonic acid metabolism_Homo sapiens_hsa005900.19666727
188Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19553389
189Thyroid cancer_Homo sapiens_hsa052160.19125136
190Tyrosine metabolism_Homo sapiens_hsa003500.18372035
191Adipocytokine signaling pathway_Homo sapiens_hsa049200.16150718
192Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.13541656

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