DEFA1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antimicrobial humoral response (GO:0019730)9.44133032
2mucosal immune response (GO:0002385)8.96957260
3organ or tissue specific immune response (GO:0002251)8.46618258
4response to peptidoglycan (GO:0032494)8.42291732
5response to fungus (GO:0009620)7.40746293
6killing of cells in other organism involved in symbiotic interaction (GO:0051883)7.10445698
7disruption of cells of other organism involved in symbiotic interaction (GO:0051818)7.10445698
8detection of other organism (GO:0098543)6.81387184
9detection of bacterium (GO:0016045)6.77604044
10oxygen transport (GO:0015671)6.36400912
11cellular extravasation (GO:0045123)5.80384506
12neutrophil activation involved in immune response (GO:0002283)5.69453526
13intracellular estrogen receptor signaling pathway (GO:0030520)5.61655972
14negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)5.50941913
15positive regulation of interleukin-8 biosynthetic process (GO:0045416)5.46882145
16cell killing (GO:0001906)5.40341378
17neutrophil activation (GO:0042119)5.30387757
18gas transport (GO:0015669)5.28318796
19defense response to Gram-positive bacterium (GO:0050830)5.23214636
20leukocyte migration involved in inflammatory response (GO:0002523)5.13552334
21response to immune response of other organism involved in symbiotic interaction (GO:0052564)5.02838018
22response to host immune response (GO:0052572)5.02838018
23negative regulation of growth of symbiont in host (GO:0044130)4.91799887
24negative regulation of growth of symbiont involved in interaction with host (GO:0044146)4.91799887
25modulation of growth of symbiont involved in interaction with host (GO:0044144)4.91799887
26regulation of growth of symbiont in host (GO:0044126)4.91799887
27granulocyte activation (GO:0036230)4.79703540
28detection of external biotic stimulus (GO:0098581)4.77381053
29leukocyte aggregation (GO:0070486)4.64725451
30protoporphyrinogen IX metabolic process (GO:0046501)4.63504563
31response to host (GO:0075136)4.57028869
32response to host defenses (GO:0052200)4.57028869
33response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.57028869
34detection of biotic stimulus (GO:0009595)4.35683139
35protoporphyrinogen IX biosynthetic process (GO:0006782)4.34919671
36positive regulation of gamma-delta T cell activation (GO:0046645)4.29089518
37negative regulation of interleukin-8 production (GO:0032717)4.26145141
38regulation of interleukin-8 biosynthetic process (GO:0045414)4.17002631
39hemoglobin metabolic process (GO:0020027)4.14251425
40negative regulation of erythrocyte differentiation (GO:0045647)4.07944093
41superoxide anion generation (GO:0042554)4.04333456
42positive regulation by symbiont of host defense response (GO:0052509)3.73543343
43modulation by symbiont of host defense response (GO:0052031)3.73543343
44modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.73543343
45modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.73543343
46positive regulation by organism of defense response of other organism involved in symbiotic interact3.73543343
47modulation by symbiont of host immune response (GO:0052553)3.73543343
48defense response to bacterium (GO:0042742)3.67572421
49respiratory burst (GO:0045730)3.62181930
50phagosome maturation (GO:0090382)3.54237946
51regulation of natural killer cell differentiation (GO:0032823)3.53404249
52negative regulation of cell killing (GO:0031342)3.51192652
53negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.51192652
54production of molecular mediator involved in inflammatory response (GO:0002532)3.46241653
55negative regulation of interleukin-6 production (GO:0032715)3.46015674
56modification of morphology or physiology of other organism (GO:0035821)3.40764825
57cellular response to interleukin-6 (GO:0071354)3.39417266
58neutrophil mediated immunity (GO:0002446)3.34724308
59positive regulation of toll-like receptor signaling pathway (GO:0034123)3.34651247
60antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.30740054
61response to bacterium (GO:0009617)3.28506628
62leukocyte degranulation (GO:0043299)3.28176691
63negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)3.28101139
64regulation of mast cell degranulation (GO:0043304)3.25010130
65myeloid cell development (GO:0061515)3.10931005
66macrophage activation involved in immune response (GO:0002281)3.10637463
67porphyrin-containing compound biosynthetic process (GO:0006779)3.09450782
68imidazole-containing compound metabolic process (GO:0052803)3.08931759
69activated T cell proliferation (GO:0050798)3.06668492
70regulation of gamma-delta T cell activation (GO:0046643)3.05677462
71negative regulation of interleukin-12 production (GO:0032695)3.04286500
72myeloid cell activation involved in immune response (GO:0002275)3.03077128
73mast cell activation (GO:0045576)3.03043245
74citrulline biosynthetic process (GO:0019240)2.99640355
75regulation of mast cell activation involved in immune response (GO:0033006)2.98029079
76neutrophil chemotaxis (GO:0030593)2.97054782
77regulation of mast cell activation (GO:0033003)2.96411896
78negative regulation of lymphocyte mediated immunity (GO:0002707)2.95420128
79positive regulation of osteoblast proliferation (GO:0033690)2.94941617
80regulation of myeloid leukocyte mediated immunity (GO:0002886)2.93883891
81erythrocyte maturation (GO:0043249)2.93574518
82detection of molecule of bacterial origin (GO:0032490)2.93216327
83regulation of leukocyte degranulation (GO:0043300)2.91071355
84neutrophil migration (GO:1990266)2.89597013
85response to muramyl dipeptide (GO:0032495)2.89551472
86regulation of B cell receptor signaling pathway (GO:0050855)2.87967920
87erythrocyte development (GO:0048821)2.86881611
88negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.85944198
89megakaryocyte development (GO:0035855)2.85453807
90microglial cell activation (GO:0001774)2.84302984
91positive regulation of granulocyte differentiation (GO:0030854)2.83625003
92positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.83512010
93response to methylmercury (GO:0051597)2.78348398
94positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.77679331
95heme biosynthetic process (GO:0006783)2.77382881
96innate immune response in mucosa (GO:0002227)10.6826389
97killing of cells of other organism (GO:0031640)10.1912334
98disruption of cells of other organism (GO:0044364)10.1912334
99antibacterial humoral response (GO:0019731)10.1297994
100defense response to fungus (GO:0050832)10.0136145

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.68366283
2MECOM_23826213_ChIP-Seq_KASUMI_Mouse4.04177708
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.80768453
4GATA1_22025678_ChIP-Seq_K562_Human3.75897427
5MYB_21317192_ChIP-Seq_ERMYB_Mouse3.46092035
6VDR_21846776_ChIP-Seq_THP-1_Human3.42950928
7SCL_19346495_ChIP-Seq_HPC-7_Human3.25852370
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.25550819
9VDR_24763502_ChIP-Seq_THP-1_Human3.21922511
10IRF8_21731497_ChIP-ChIP_J774_Mouse3.19041377
11IRF8_27001747_Chip-Seq_BMDM_Mouse3.00230511
12SPI1_23547873_ChIP-Seq_NB4_Human2.97566666
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.96234668
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.90809380
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.82132827
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.80747137
17GATA1_19941826_ChIP-Seq_K562_Human2.68985629
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.48330233
19RUNX1_22412390_ChIP-Seq_EML_Mouse2.44103960
20BRD4_27068464_Chip-Seq_AML-cells_Mouse2.31736731
21SPI1_23127762_ChIP-Seq_K562_Human2.31333316
22VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.31127694
23MYB_26560356_Chip-Seq_TH2_Human2.30628674
24MAF_26560356_Chip-Seq_TH1_Human2.28273420
25MYC_22102868_ChIP-Seq_BL_Human2.27443254
26STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.24304154
27UTX_26944678_Chip-Seq_JUKART_Human2.23985848
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.21528311
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.14963298
30FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.13307943
31GATA1_19941827_ChIP-Seq_MEL_Mouse2.11733596
32RUNX_20019798_ChIP-Seq_JUKART_Human2.10469341
33TCF7_22412390_ChIP-Seq_EML_Mouse2.09109091
34MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.08523883
35TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.08419441
36IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.03944012
37STAT4_19710469_ChIP-ChIP_TH1__Mouse2.02446147
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.00724486
39MYB_26560356_Chip-Seq_TH1_Human1.93996085
40IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.87568668
41VDR_24787735_ChIP-Seq_THP-1_Human1.85597626
42GATA2_19941826_ChIP-Seq_K562_Human1.85447029
43GATA1_22383799_ChIP-Seq_G1ME_Mouse1.77715544
44Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.74908482
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.72969548
46GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.68998882
47KDM2B_26808549_Chip-Seq_DND41_Human1.66637362
48LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.66284343
49KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.64452889
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.63139724
51GATA2_22383799_ChIP-Seq_G1ME_Mouse1.62382157
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.62029843
53CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.59691766
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.57168165
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.52045775
56MAF_26560356_Chip-Seq_TH2_Human1.51297737
57SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.51231937
58KDM2B_26808549_Chip-Seq_SUP-B15_Human1.50541736
59PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.49704095
60KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.49483442
61PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.49039757
62CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.45072898
63RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.45061054
64PU_27001747_Chip-Seq_BMDM_Mouse1.40943890
65GATA3_27048872_Chip-Seq_THYMUS_Human1.38770470
66SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37315213
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36517695
68E2F7_22180533_ChIP-Seq_HELA_Human1.35635327
69KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.32111076
70GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.32110737
71CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30526961
72CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26130960
73GATA3_26560356_Chip-Seq_TH2_Human1.24487947
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23097396
75TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20922117
76BCOR_27268052_Chip-Seq_Bcells_Human1.20582893
77CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19963882
78NCOR1_26117541_ChIP-Seq_K562_Human1.18518413
79SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17037034
80GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12202534
81PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11552587
82FOXM1_23109430_ChIP-Seq_U2OS_Human1.11383409
83EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.11371426
84ELK3_25401928_ChIP-Seq_HUVEC_Human1.10654475
85STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09166730
86PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05747705
87STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05301692
88TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05105748
89RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02950791
90PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01796075
91KDM2B_26808549_Chip-Seq_JURKAT_Human1.01495946
92LXR_22292898_ChIP-Seq_THP-1_Human1.01128506
93STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97108757
94BCL6_27268052_Chip-Seq_Bcells_Human0.95738680
95SPI1_20517297_ChIP-Seq_HL60_Human0.93881290
96HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92258806
97RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.92103484
98CTCF_27219007_Chip-Seq_ERYTHROID_Human0.90237109
99ELF1_20517297_ChIP-Seq_JURKAT_Human0.84555159
100CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.81191236

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.16795726
2MP0003436_decreased_susceptibility_to4.07920869
3MP0009785_altered_susceptibility_to3.94596521
4MP0003656_abnormal_erythrocyte_physiolo3.71607739
5MP0003724_increased_susceptibility_to3.64951042
6MP0004147_increased_porphyrin_level3.33169540
7MP0002419_abnormal_innate_immunity3.27679226
8MP0005025_abnormal_response_to3.24792369
9MP0001835_abnormal_antigen_presentation2.91111245
10MP0009278_abnormal_bone_marrow2.63514982
11MP0005464_abnormal_platelet_physiology2.50027893
12MP0000685_abnormal_immune_system2.42492438
13MP0005000_abnormal_immune_tolerance2.37267867
14MP0008260_abnormal_autophagy2.35114570
15MP0003191_abnormal_cellular_cholesterol2.30296920
16MP0002420_abnormal_adaptive_immunity2.28657062
17MP0001819_abnormal_immune_cell2.24915401
18MP0001800_abnormal_humoral_immune2.21548757
19MP0005387_immune_system_phenotype2.16642733
20MP0001790_abnormal_immune_system2.16642733
21MP0002452_abnormal_antigen_presenting2.10285625
22MP0001545_abnormal_hematopoietic_system2.09314803
23MP0005397_hematopoietic_system_phenotyp2.09314803
24MP0003828_pulmonary_edema2.08079652
25MP0002723_abnormal_immune_serum2.07368178
26MP0002398_abnormal_bone_marrow2.04554703
27MP0002396_abnormal_hematopoietic_system2.00502010
28MP0001533_abnormal_skeleton_physiology1.99277804
29MP0002148_abnormal_hypersensitivity_rea1.96232958
30MP0002405_respiratory_system_inflammati1.92684137
31MP0005671_abnormal_response_to1.86896634
32MP0002138_abnormal_hepatobiliary_system1.85746436
33MP0003763_abnormal_thymus_physiology1.80114992
34MP0003172_abnormal_lysosome_physiology1.80065442
35MP0003300_gastrointestinal_ulcer1.78529181
36MP0005083_abnormal_biliary_tract1.76139882
37MP0000689_abnormal_spleen_morphology1.74219627
38MP0002722_abnormal_immune_system1.73855290
39MP0000716_abnormal_immune_system1.73653788
40MP0002132_abnormal_respiratory_system1.68948851
41MP0001845_abnormal_inflammatory_respons1.68902216
42MP0000465_gastrointestinal_hemorrhage1.67774573
43MP0006082_CNS_inflammation1.65151386
44MP0003045_fibrosis1.59667864
45MP0002429_abnormal_blood_cell1.57814642
46MP0001851_eye_inflammation1.56354338
47MP0009333_abnormal_splenocyte_physiolog1.53070282
48MP0004947_skin_inflammation1.47785545
49MP0009764_decreased_sensitivity_to1.46704247
50MP0002166_altered_tumor_susceptibility1.46026764
51MP0003075_altered_response_to1.43782530
52MP0010155_abnormal_intestine_physiology1.40761261
53MP0000703_abnormal_thymus_morphology1.40155577
54MP0004808_abnormal_hematopoietic_stem1.38665966
55MP0002009_preneoplasia1.33668567
56MP0004883_abnormal_blood_vessel1.26410107
57MP0008469_abnormal_protein_level1.21803209
58MP0005076_abnormal_cell_differentiation1.14685383
59MP0005058_abnormal_lysosome_morphology1.11279641
60MP0001853_heart_inflammation1.09113212
61MP0005164_abnormal_response_to1.06823081
62MP0000858_altered_metastatic_potential1.00873932
63MP0004381_abnormal_hair_follicle1.00384071
64MP0003221_abnormal_cardiomyocyte_apopto0.96391710
65MP0003866_abnormal_defecation0.96327557
66MP0009763_increased_sensitivity_to0.95720004
67MP0009765_abnormal_xenobiotic_induced0.93541713
68MP0003806_abnormal_nucleotide_metabolis0.91655211
69MP0000343_altered_response_to0.88851165
70MP0002006_tumorigenesis0.87422467
71MP0002998_abnormal_bone_remodeling0.86365162
72MP0005075_abnormal_melanosome_morpholog0.84082816
73MP0001663_abnormal_digestive_system0.82566131
74MP0004510_myositis0.82090190
75MP0005166_decreased_susceptibility_to0.81514133
76MP0000609_abnormal_liver_physiology0.78808902
77MP0001986_abnormal_taste_sensitivity0.75131207
78MP0005390_skeleton_phenotype0.75086685
79MP0005636_abnormal_mineral_homeostasis0.74309682
80MP0003795_abnormal_bone_structure0.72347146
81MP0008004_abnormal_stomach_pH0.72046720
82MP0005310_abnormal_salivary_gland0.71913487
83MP0002877_abnormal_melanocyte_morpholog0.70902640
84MP0009931_abnormal_skin_appearance0.70855960
85MP0003690_abnormal_glial_cell0.68495714
86MP0004130_abnormal_muscle_cell0.67866377
87MP0000249_abnormal_blood_vessel0.66072854
88MP0003448_altered_tumor_morphology0.65848677
89MP0001873_stomach_inflammation0.65594917
90MP0002019_abnormal_tumor_incidence0.65084175
91MP0000490_abnormal_crypts_of0.63294995
92MP0000015_abnormal_ear_pigmentation0.62195342
93MP0003183_abnormal_peptide_metabolism0.61593475
94MP0009115_abnormal_fat_cell0.57717684
95MP0003566_abnormal_cell_adhesion0.57182372
96MP0005319_abnormal_enzyme/_coenzyme0.56934816
97MP0005376_homeostasis/metabolism_phenot0.56384374
98MP0005621_abnormal_cell_physiology0.56031597
99MP0008057_abnormal_DNA_replication0.55977208
100MP0009840_abnormal_foam_cell0.52964620

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)8.80128805
2Hypochromic anemia (HP:0001931)6.62030138
3Eczematoid dermatitis (HP:0000976)5.92045187
4Recurrent abscess formation (HP:0002722)5.43525831
5Microcytic anemia (HP:0001935)5.33698541
6Recurrent bacterial skin infections (HP:0005406)5.21599021
7Abnormal hemoglobin (HP:0011902)5.09468166
8Stomatitis (HP:0010280)4.69249878
9Polycythemia (HP:0001901)4.65972775
10Abnormality of macrophages (HP:0004311)4.63263113
11Poikilocytosis (HP:0004447)4.49568786
12Toxemia of pregnancy (HP:0100603)4.45514023
13Recurrent gram-negative bacterial infections (HP:0005420)4.44277383
14Myositis (HP:0100614)4.24105185
15Prolonged bleeding time (HP:0003010)4.06649662
16Obstructive lung disease (HP:0006536)3.80717036
17Chronic obstructive pulmonary disease (HP:0006510)3.80717036
18Abnormal delayed hypersensitivity skin test (HP:0002963)3.68900974
19Elevated erythrocyte sedimentation rate (HP:0003565)3.63118501
20Orchitis (HP:0100796)3.62156912
21Retrobulbar optic neuritis (HP:0100654)3.53636180
22Optic neuritis (HP:0100653)3.53636180
23Mediastinal lymphadenopathy (HP:0100721)3.52069965
24Urticaria (HP:0001025)3.43516699
25Recurrent fungal infections (HP:0002841)3.42195059
26Recurrent skin infections (HP:0001581)3.30838057
27Meningitis (HP:0001287)3.30158449
28Gastrointestinal infarctions (HP:0005244)3.25794441
29Abnormality of iron homeostasis (HP:0011031)3.21207677
30Gingivitis (HP:0000230)3.15701744
31Keratoconjunctivitis sicca (HP:0001097)3.15563963
32Epistaxis (HP:0000421)3.08293683
33Petechiae (HP:0000967)3.07021475
34Cholelithiasis (HP:0001081)3.05986273
35Osteomyelitis (HP:0002754)2.97859414
36Abnormal platelet volume (HP:0011876)2.88665216
37Keratoconjunctivitis (HP:0001096)2.88001368
38Increased IgE level (HP:0003212)2.87508581
39Paralysis (HP:0003470)2.86603602
40Recurrent cutaneous fungal infections (HP:0011370)2.83509712
41Chronic mucocutaneous candidiasis (HP:0002728)2.83509712
42Encephalitis (HP:0002383)2.77039764
43Amyloidosis (HP:0011034)2.74193252
44Anorexia (HP:0002039)2.73291964
45Spontaneous hematomas (HP:0007420)2.72004913
46Abnormal gallbladder morphology (HP:0012437)2.71311719
47Gingival bleeding (HP:0000225)2.71146050
48Abnormality of transition element cation homeostasis (HP:0011030)2.69570692
49Cellulitis (HP:0100658)2.69032269
50Episodic fever (HP:0001954)2.62195663
51Vasculitis (HP:0002633)2.59732680
52Granulocytopenia (HP:0001913)2.50932430
53Recurrent viral infections (HP:0004429)2.40279566
54Leukocytosis (HP:0001974)2.33213158
55Hemoptysis (HP:0002105)2.32237954
56Increased mean platelet volume (HP:0011877)2.32200063
57Pulmonary infiltrates (HP:0002113)2.29317612
58Hepatosplenomegaly (HP:0001433)2.25513693
59Chest pain (HP:0100749)2.25452832
60Pustule (HP:0200039)2.23222438
61Thrombophlebitis (HP:0004418)2.21326393
62Abnormality of T cell physiology (HP:0011840)2.19055385
63Systemic lupus erythematosus (HP:0002725)2.16906938
64Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.15205964
65Reticulocytosis (HP:0001923)2.13083181
66Acanthocytosis (HP:0001927)2.10608782
67Abnormality of the pericardium (HP:0001697)2.09821628
68Increased serum ferritin (HP:0003281)2.09758958
69Diaphragmatic weakness (HP:0009113)2.09466909
70Autoimmune thrombocytopenia (HP:0001973)2.08399001
71Arterial thrombosis (HP:0004420)2.07436866
72Panhypogammaglobulinemia (HP:0003139)2.07372744
73Abnormality of the fingertips (HP:0001211)2.07119233
74Increased cerebral lipofuscin (HP:0011813)2.06625872
75Slow saccadic eye movements (HP:0000514)2.04206614
76Purpura (HP:0000979)2.02159725
77Hypochromic microcytic anemia (HP:0004840)11.2828681
78Impaired platelet aggregation (HP:0003540)1.98616585
79Abnormal platelet function (HP:0011869)1.98616585
80Pallor (HP:0000980)1.97519050
81Skin rash (HP:0000988)1.95109508
82Abnormality of T cells (HP:0002843)1.95057698
83Skin ulcer (HP:0200042)1.93707219
84Inflammation of the large intestine (HP:0002037)1.93525832
85Menorrhagia (HP:0000132)1.90667140
86Abnormality of B cell number (HP:0010975)1.89240539
87Sepsis (HP:0100806)1.89222532
88Abnormality of the gallbladder (HP:0005264)1.89061476
89Abnormality of the pleura (HP:0002103)1.88756324
90Cutaneous photosensitivity (HP:0000992)1.87912578
91Paresthesia (HP:0003401)1.86850059
92Pulmonary embolism (HP:0002204)1.86756135
93Eosinophilia (HP:0001880)1.85115350
94Gastrointestinal inflammation (HP:0004386)1.84063508
95Increased neuronal autofluorescent lipopigment (HP:0002074)1.81074723
96Autoimmune hemolytic anemia (HP:0001890)1.80759793
97Splenomegaly (HP:0001744)1.79341830
98Increased IgM level (HP:0003496)1.78935135
99Hypergammaglobulinemia (HP:0010702)1.76450198
100Gangrene (HP:0100758)1.74570707

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.63233387
2MAP2K34.33897061
3PRPF4B4.01187750
4GRK63.29424704
5MAP4K12.86688128
6IRAK42.53950152
7FES2.35235400
8TAOK12.34083731
9TNK22.23305388
10BLK2.22506854
11MAP3K32.22400725
12ZAP702.14669240
13BTK2.12651179
14TYK22.11435651
15SYK1.93948841
16ERN11.87879061
17TAOK21.85198998
18TEC1.83661601
19CSK1.77085693
20MAP3K61.74999385
21MAP3K111.72742146
22EPHB11.69354769
23FGR1.63148483
24PIK3CG1.60273296
25HCK1.48979907
26MAP3K141.44457982
27TXK1.41086490
28LYN1.35093022
29IRAK11.31878139
30JAK21.28917523
31MARK31.22355920
32KIT1.20188549
33ITK1.18899585
34MAP3K11.17958953
35SIK31.13131878
36IKBKE1.10039268
37YES11.09585548
38JAK31.01520751
39TESK20.98411912
40MAP3K50.96680087
41SMG10.96451184
42MAPK120.95765080
43KSR20.95328009
44EIF2AK10.94492175
45CLK10.94343479
46JAK10.93414376
47PTK2B0.93099242
48LCK0.92038863
49CSF1R0.89921558
50TBK10.80279272
51CDK190.79713633
52IRAK20.79598361
53EPHA30.79410097
54HIPK20.78678921
55MAP3K130.76859149
56PDK10.73793970
57CDK120.73768410
58MAP2K40.72853153
59PDK20.72288505
60MARK20.70783238
61BMPR20.69566000
62PDPK10.67027525
63MAPK70.63991698
64IKBKB0.63819299
65PIK3CA0.60872449
66TRPM70.60000424
67SIK20.59991679
68DAPK20.59068685
69STK100.57582094
70CDK60.54058175
71RET0.53355020
72FYN0.52948891
73PTK60.52559943
74TRIB30.49253717
75PIM10.48956851
76SGK30.48175124
77MAPK40.47239076
78WNK10.46810484
79CAMK1D0.46523643
80TAOK30.46353937
81TGFBR20.46121108
82MAP2K60.46082387
83RPS6KL10.45719155
84RPS6KC10.45719155
85CAMKK20.45603151
86LRRK20.44582663
87STK110.43303198
88ALK0.41061920
89MATK0.40602883
90BMX0.38467236
91MAP3K20.37647236
92MAPKAPK20.37418305
93RPS6KA60.36414504
94PRKCQ0.35032000
95DYRK30.34584954
96PRKD20.34398664
97NLK0.33156551
98PRKCD0.32816706
99KSR10.32668701
100RAF10.32567887

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.84137586
2Malaria_Homo sapiens_hsa051443.49198552
3African trypanosomiasis_Homo sapiens_hsa051432.83287082
4Osteoclast differentiation_Homo sapiens_hsa043802.81465954
5Leishmaniasis_Homo sapiens_hsa051402.56065874
6Staphylococcus aureus infection_Homo sapiens_hsa051502.44958759
7Tuberculosis_Homo sapiens_hsa051522.24561534
8Asthma_Homo sapiens_hsa053102.22897311
9B cell receptor signaling pathway_Homo sapiens_hsa046621.95609958
10NOD-like receptor signaling pathway_Homo sapiens_hsa046211.88737263
11Acute myeloid leukemia_Homo sapiens_hsa052211.84791800
12Hematopoietic cell lineage_Homo sapiens_hsa046401.82570535
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.81588397
14Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.76543302
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.74849035
16Legionellosis_Homo sapiens_hsa051341.70080565
17Non-small cell lung cancer_Homo sapiens_hsa052231.66001435
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.62987671
19Chemokine signaling pathway_Homo sapiens_hsa040621.52384951
20Measles_Homo sapiens_hsa051621.52021994
21Other glycan degradation_Homo sapiens_hsa005111.50083521
22Leukocyte transendothelial migration_Homo sapiens_hsa046701.40487753
23Platelet activation_Homo sapiens_hsa046111.37041073
24Influenza A_Homo sapiens_hsa051641.36944683
25T cell receptor signaling pathway_Homo sapiens_hsa046601.35336016
26Pancreatic cancer_Homo sapiens_hsa052121.32664521
27Hepatitis B_Homo sapiens_hsa051611.29218139
28Primary immunodeficiency_Homo sapiens_hsa053401.28580353
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.27173362
30Chronic myeloid leukemia_Homo sapiens_hsa052201.25936085
31Phagosome_Homo sapiens_hsa041451.23937576
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.23089423
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.22292100
34Toxoplasmosis_Homo sapiens_hsa051451.20143158
35Regulation of autophagy_Homo sapiens_hsa041401.18572990
36Herpes simplex infection_Homo sapiens_hsa051681.18103453
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.15026159
38TNF signaling pathway_Homo sapiens_hsa046681.14000218
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.12731312
40Pertussis_Homo sapiens_hsa051331.12580254
41Renal cell carcinoma_Homo sapiens_hsa052111.08022180
42Graft-versus-host disease_Homo sapiens_hsa053321.06562672
43Nitrogen metabolism_Homo sapiens_hsa009101.06329350
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.05431479
45Carbohydrate digestion and absorption_Homo sapiens_hsa049731.05338444
46Transcriptional misregulation in cancer_Homo sapiens_hsa052021.04452080
47Hepatitis C_Homo sapiens_hsa051601.03676373
48Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.03302741
49Allograft rejection_Homo sapiens_hsa053301.01396483
50FoxO signaling pathway_Homo sapiens_hsa040680.95751778
51Autoimmune thyroid disease_Homo sapiens_hsa053200.94143468
52Amoebiasis_Homo sapiens_hsa051460.93477982
53Shigellosis_Homo sapiens_hsa051310.92928813
54VEGF signaling pathway_Homo sapiens_hsa043700.89854483
55Salmonella infection_Homo sapiens_hsa051320.86701838
56Pentose phosphate pathway_Homo sapiens_hsa000300.86396032
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85080647
58HIF-1 signaling pathway_Homo sapiens_hsa040660.84295028
59Apoptosis_Homo sapiens_hsa042100.82370654
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.81847571
61Endometrial cancer_Homo sapiens_hsa052130.78595507
62Type II diabetes mellitus_Homo sapiens_hsa049300.77812486
63Antigen processing and presentation_Homo sapiens_hsa046120.77811516
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.77580308
65Lysosome_Homo sapiens_hsa041420.76996382
66Prolactin signaling pathway_Homo sapiens_hsa049170.76382553
67Collecting duct acid secretion_Homo sapiens_hsa049660.73601519
68Choline metabolism in cancer_Homo sapiens_hsa052310.73202360
69Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73090657
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72286249
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71704253
72Viral carcinogenesis_Homo sapiens_hsa052030.69354267
73Glycosaminoglycan degradation_Homo sapiens_hsa005310.68811713
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68140685
75Colorectal cancer_Homo sapiens_hsa052100.64864758
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63294851
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.63228534
78Type I diabetes mellitus_Homo sapiens_hsa049400.63056892
79mTOR signaling pathway_Homo sapiens_hsa041500.62154727
80Endocytosis_Homo sapiens_hsa041440.62094762
81GnRH signaling pathway_Homo sapiens_hsa049120.59130410
82Epstein-Barr virus infection_Homo sapiens_hsa051690.58127828
83Rheumatoid arthritis_Homo sapiens_hsa053230.57659140
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.56770302
85Prostate cancer_Homo sapiens_hsa052150.56141673
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.56114935
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53325346
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.53114046
89Inositol phosphate metabolism_Homo sapiens_hsa005620.52474026
90Bladder cancer_Homo sapiens_hsa052190.51504921
91Viral myocarditis_Homo sapiens_hsa054160.50625085
92Insulin resistance_Homo sapiens_hsa049310.49996198
93HTLV-I infection_Homo sapiens_hsa051660.49337739
94Glioma_Homo sapiens_hsa052140.48451995
95Notch signaling pathway_Homo sapiens_hsa043300.47294834
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46512326
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45551700
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44353096
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42810858
100Dorso-ventral axis formation_Homo sapiens_hsa043200.42612766

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