DEFA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 3, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 1 by only one amino acid. This gene and the gene encoding defensin, alpha 1 are both subject to copy number variation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* mucosal immune response (GO:0002385)8.53899165
2response to peptidoglycan (GO:0032494)8.25951287
3oxygen transport (GO:0015671)8.11070520
4angiotensin maturation (GO:0002003)8.00921883
5* organ or tissue specific immune response (GO:0002251)7.99867176
6killing of cells in other organism involved in symbiotic interaction (GO:0051883)7.91586381
7disruption of cells of other organism involved in symbiotic interaction (GO:0051818)7.91586381
8* response to fungus (GO:0009620)7.65935624
9detection of bacterium (GO:0016045)7.18325116
10detection of other organism (GO:0098543)7.16583741
11protoporphyrinogen IX metabolic process (GO:0046501)7.12975974
12positive regulation of interleukin-8 biosynthetic process (GO:0045416)6.87405140
13gas transport (GO:0015669)6.85582858
14protoporphyrinogen IX biosynthetic process (GO:0006782)6.70462726
15cellular extravasation (GO:0045123)6.50355063
16vitamin A metabolic process (GO:0006776)5.99864510
17regulation of bile acid biosynthetic process (GO:0070857)5.89848438
18regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.86560577
19hemoglobin metabolic process (GO:0020027)5.84503793
20flavonoid metabolic process (GO:0009812)5.79742666
21neutrophil activation (GO:0042119)5.63464134
22* cell killing (GO:0001906)5.53878765
23bundle of His cell to Purkinje myocyte communication (GO:0086069)5.51506956
24digestive system process (GO:0022600)5.50102650
25neutrophil activation involved in immune response (GO:0002283)5.50055452
26negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)5.42186116
27negative regulation of interleukin-8 production (GO:0032717)5.41827898
28negative regulation of growth of symbiont in host (GO:0044130)5.33781627
29negative regulation of growth of symbiont involved in interaction with host (GO:0044146)5.33781627
30modulation of growth of symbiont involved in interaction with host (GO:0044144)5.33781627
31regulation of growth of symbiont in host (GO:0044126)5.33781627
32membrane repolarization during cardiac muscle cell action potential (GO:0086013)5.26968165
33regulation of interleukin-8 biosynthetic process (GO:0045414)5.17484085
34leukocyte migration involved in inflammatory response (GO:0002523)5.17038499
35granulocyte activation (GO:0036230)5.16504871
36actin filament depolymerization (GO:0030042)5.14335473
37* defense response to Gram-positive bacterium (GO:0050830)5.09130298
38virion attachment to host cell (GO:0019062)5.05288605
39adhesion of symbiont to host cell (GO:0044650)5.05288605
40UDP-N-acetylglucosamine metabolic process (GO:0006047)5.04402691
41drug catabolic process (GO:0042737)4.98853321
42porphyrin-containing compound biosynthetic process (GO:0006779)4.94045886
43transepithelial transport (GO:0070633)4.84622301
44negative regulation of erythrocyte differentiation (GO:0045647)4.81201991
45NADH metabolic process (GO:0006734)4.77998992
46intestinal epithelial cell development (GO:0060576)4.77980079
47regulation of respiratory burst (GO:0060263)4.75045088
48superoxide anion generation (GO:0042554)4.74613062
49glucose 6-phosphate metabolic process (GO:0051156)4.74158644
50detection of external biotic stimulus (GO:0098581)4.67309033
51* antibacterial humoral response (GO:0019731)4.65991975
52sperm capacitation (GO:0048240)4.65801087
53membrane repolarization during action potential (GO:0086011)4.64750182
54* antimicrobial humoral response (GO:0019730)4.58991761
55* disruption of cells of other organism (GO:0044364)4.49600239
56* killing of cells of other organism (GO:0031640)4.49600239
57urea metabolic process (GO:0019627)4.49213011
58urea cycle (GO:0000050)4.49213011
59leukocyte aggregation (GO:0070486)4.45396912
60imidazole-containing compound metabolic process (GO:0052803)4.44744036
61detection of biotic stimulus (GO:0009595)4.43373190
62regulation of Golgi to plasma membrane protein transport (GO:0042996)4.43296975
63* defense response to fungus (GO:0050832)4.41135869
64regulation of triglyceride catabolic process (GO:0010896)4.35616272
65triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.35026552
66tetrapyrrole biosynthetic process (GO:0033014)4.27935566
67regulation of natural killer cell differentiation (GO:0032823)4.26753255
68regulation of cholesterol esterification (GO:0010872)4.26062953
69lipoprotein metabolic process (GO:0042157)4.25615563
70plasma lipoprotein particle assembly (GO:0034377)4.22921897
71bicarbonate transport (GO:0015701)4.20075148
72heme biosynthetic process (GO:0006783)4.19991621
73protein-lipid complex assembly (GO:0065005)4.08861340
74purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.07982047
753-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.07982047
76adhesion of symbiont to host (GO:0044406)4.04306427
77* intracellular estrogen receptor signaling pathway (GO:0030520)4.01198414
78modified amino acid transport (GO:0072337)3.99715139
79nitrogen cycle metabolic process (GO:0071941)3.98492720
80phospholipid efflux (GO:0033700)3.97351485
81* defense response to bacterium (GO:0042742)3.96891675
82response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.95484426
83response to host immune response (GO:0052572)3.95484426
84erythrocyte maturation (GO:0043249)3.94841239
85cellular response to hepatocyte growth factor stimulus (GO:0035729)3.89904914
86response to hepatocyte growth factor (GO:0035728)3.89904914
87response to methylmercury (GO:0051597)3.89658831
88diacylglycerol metabolic process (GO:0046339)3.88719047
89erythrocyte development (GO:0048821)3.87328932
90porphyrin-containing compound metabolic process (GO:0006778)3.87255611
91very-low-density lipoprotein particle assembly (GO:0034379)3.86578492
92ventricular cardiac muscle cell action potential (GO:0086005)3.85346802
93hydrogen peroxide catabolic process (GO:0042744)3.85294567
94ethanol metabolic process (GO:0006067)3.82607391
95myeloid cell development (GO:0061515)3.81569050
96regulation of cellular extravasation (GO:0002691)3.80715185
97bile acid and bile salt transport (GO:0015721)3.79639865
98regulation of cholesterol homeostasis (GO:2000188)3.77888834
99cholesterol homeostasis (GO:0042632)3.77733667
100sterol homeostasis (GO:0055092)3.74488098
101positive regulation of triglyceride lipase activity (GO:0061365)3.74327268
102positive regulation of lipoprotein lipase activity (GO:0051006)3.74327268
103fructose metabolic process (GO:0006000)3.72681449
104sulfate transmembrane transport (GO:1902358)3.72584361
105negative regulation of interleukin-6 production (GO:0032715)3.71515410
106primary alcohol catabolic process (GO:0034310)3.70552207
107homocysteine metabolic process (GO:0050667)3.64955608
108transcytosis (GO:0045056)3.57321585
109proline biosynthetic process (GO:0006561)3.56799432
110sterol transport (GO:0015918)3.56484626
111cholesterol transport (GO:0030301)3.56484626
112response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.56303366
113response to host (GO:0075136)3.56303366
114response to host defenses (GO:0052200)3.56303366
115negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)3.55702322
116digestion (GO:0007586)3.54445003
117neutrophil mediated immunity (GO:0002446)3.54286125
118calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.53481347
119cholesterol efflux (GO:0033344)3.52921263
120* response to bacterium (GO:0009617)3.51068394
121respiratory burst (GO:0045730)3.46939100
122phagosome maturation (GO:0090382)3.46233922
123regulation of digestive system process (GO:0044058)3.44741071
124hormone catabolic process (GO:0042447)3.41672560
125positive regulation of digestive system process (GO:0060456)3.41359225
126heme metabolic process (GO:0042168)3.37152048
127filopodium assembly (GO:0046847)3.36237902
128regulation of mast cell degranulation (GO:0043304)3.32826697
129cellular response to interleukin-6 (GO:0071354)3.31982303
130* modification of morphology or physiology of other organism (GO:0035821)3.31678295
131positive regulation of gamma-delta T cell activation (GO:0046645)3.29728511
132drinking behavior (GO:0042756)3.26633197
133regulation of hydrogen peroxide metabolic process (GO:0010310)3.26436556
134phenylpropanoid metabolic process (GO:0009698)3.25620183
135lipoprotein transport (GO:0042953)3.23542179
136sulfation (GO:0051923)3.21442215
137production of molecular mediator involved in inflammatory response (GO:0002532)3.19093414
138sulfur compound transport (GO:0072348)3.19078748
139O-glycan processing (GO:0016266)3.18891238
140maintenance of gastrointestinal epithelium (GO:0030277)3.18043877
141neutrophil chemotaxis (GO:0030593)3.16822860
142endocrine pancreas development (GO:0031018)3.15739150
143negative regulation of cholesterol transport (GO:0032375)3.15057472
144negative regulation of sterol transport (GO:0032372)3.15057472
145leukotriene biosynthetic process (GO:0019370)3.14371582
146positive regulation of osteoblast proliferation (GO:0033690)3.13975066
147regulation of heart rate by cardiac conduction (GO:0086091)3.13613987
148thyroid hormone metabolic process (GO:0042403)3.11660415
149desmosome organization (GO:0002934)3.11186452
150receptor guanylyl cyclase signaling pathway (GO:0007168)3.11117491
151positive regulation of fatty acid biosynthetic process (GO:0045723)3.10706060
152peptide hormone processing (GO:0016486)3.10038597
153cellular glucuronidation (GO:0052695)3.10006959
154megakaryocyte development (GO:0035855)3.09573007
155cytidine metabolic process (GO:0046087)3.09404472
156cytidine catabolic process (GO:0006216)3.09404472
157cytidine deamination (GO:0009972)3.09404472
158neutrophil migration (GO:1990266)3.08960111
159citrulline biosynthetic process (GO:0019240)3.06722105
160leukocyte degranulation (GO:0043299)3.06261781
161regulation of mast cell activation involved in immune response (GO:0033006)3.05150616
162regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.05017399
163negative regulation of keratinocyte proliferation (GO:0010839)3.03659062
164trophectodermal cell differentiation (GO:0001829)3.03212737
165regulation of leukocyte degranulation (GO:0043300)3.03104970
166regulation of myeloid leukocyte mediated immunity (GO:0002886)3.02385505
167phospholipid homeostasis (GO:0055091)3.01306629
168sulfate transport (GO:0008272)3.00812113
169regulation of vitamin metabolic process (GO:0030656)3.00550519
170drug metabolic process (GO:0017144)3.00080128
171activated T cell proliferation (GO:0050798)2.96012892
172positive regulation of toll-like receptor signaling pathway (GO:0034123)2.94285742
173leukotriene metabolic process (GO:0006691)2.93727755
174mast cell activation (GO:0045576)2.92655497
175regulation of mast cell activation (GO:0033003)2.90472125
176regulation of female gonad development (GO:2000194)2.86311542
177granulocyte migration (GO:0097530)2.84215968
178positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.78769650
179pentose-phosphate shunt (GO:0006098)2.75514713
180regulation of regulated secretory pathway (GO:1903305)2.74784438
181negative regulation of tumor necrosis factor production (GO:0032720)2.73370303
182regulation of response to osmotic stress (GO:0047484)2.72750984
183response to interleukin-6 (GO:0070741)2.70502545
184regulation of interleukin-8 production (GO:0032677)2.69826523
185modification by host of symbiont morphology or physiology (GO:0051851)2.69123786
186defense response to Gram-negative bacterium (GO:0050829)2.67850633
187regulation of erythrocyte differentiation (GO:0045646)2.67463407
188hydrogen peroxide metabolic process (GO:0042743)2.66292994
1893-UTR-mediated mRNA stabilization (GO:0070935)2.65355804
190myeloid leukocyte mediated immunity (GO:0002444)2.65293660
191response to muramyl dipeptide (GO:0032495)2.65195930
192intestinal absorption (GO:0050892)12.4047278
193* innate immune response in mucosa (GO:0002227)10.4604428
194intestinal cholesterol absorption (GO:0030299)10.3789104

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CDX2_20551321_ChIP-Seq_CACO-2_Human6.40720606
2SOX2_27498859_Chip-Seq_STOMACH_Mouse4.41349407
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.17373998
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.88924680
5GATA1_19941826_ChIP-Seq_K562_Human3.86561068
6HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.85349706
7SCL_19346495_ChIP-Seq_HPC-7_Human3.85290775
8VDR_21846776_ChIP-Seq_THP-1_Human3.72979455
9MYB_21317192_ChIP-Seq_ERMYB_Mouse3.51596058
10VDR_24763502_ChIP-Seq_THP-1_Human3.48416800
11GATA4_25053715_ChIP-Seq_YYC3_Human3.45343944
12GATA6_25053715_ChIP-Seq_YYC3_Human3.31702908
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.18800266
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.13524657
15PPARA_22158963_ChIP-Seq_LIVER_Mouse3.05052508
16SOX2_20726797_ChIP-Seq_SW620_Human2.97771375
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.83438079
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.80129091
19SPI1_23547873_ChIP-Seq_NB4_Human2.78289857
20GATA1_22025678_ChIP-Seq_K562_Human2.78142746
21IRF8_27001747_Chip-Seq_BMDM_Mouse2.77712849
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.75750838
23GATA1_19941827_ChIP-Seq_MEL_Mouse2.65464407
24IRF8_21731497_ChIP-ChIP_J774_Mouse2.62109166
25EGR1_19374776_ChIP-ChIP_THP-1_Human2.60447379
26LXR_22158963_ChIP-Seq_LIVER_Mouse2.52787079
27RXR_22158963_ChIP-Seq_LIVER_Mouse2.48147343
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.41870532
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.41066309
30TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.40005406
31PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.34686306
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.34562645
33SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.33463411
34RUNX1_22412390_ChIP-Seq_EML_Mouse2.32333165
35BRD4_27068464_Chip-Seq_AML-cells_Mouse2.29944517
36SPI1_23127762_ChIP-Seq_K562_Human2.22527227
37E2F7_22180533_ChIP-Seq_HELA_Human2.22285937
38MYC_22102868_ChIP-Seq_BL_Human2.16996777
39TCF7_22412390_ChIP-Seq_EML_Mouse2.16343169
40CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.12561452
41UTX_26944678_Chip-Seq_JUKART_Human2.10834402
42FOXM1_23109430_ChIP-Seq_U2OS_Human2.09749989
43GATA1_22383799_ChIP-Seq_G1ME_Mouse2.09581346
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.08448360
45SRY_22984422_ChIP-ChIP_TESTIS_Rat2.07184741
46MAF_26560356_Chip-Seq_TH1_Human2.06910002
47TRIM28_21343339_ChIP-Seq_HEK293_Human2.05654965
48TP63_17297297_ChIP-ChIP_HaCaT_Human10.4934394
49PPAR_26484153_Chip-Seq_NCI-H1993_Human1.96746918
50FOXO3_23340844_ChIP-Seq_DLD1_Human1.96716025
51GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.96412004
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.92898377
53STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.92039202
54VDR_24787735_ChIP-Seq_THP-1_Human1.88429726
55MYB_26560356_Chip-Seq_TH2_Human1.86961936
56E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.85133159
57STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.85064286
58AR_21909140_ChIP-Seq_LNCAP_Human1.84880444
59FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.84802319
60KLF5_25053715_ChIP-Seq_YYC3_Human1.82604496
61RUNX1_27514584_Chip-Seq_MCF-7_Human1.81062662
62SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.77981632
63Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.77597087
64NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.76559078
65KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.75415546
66LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.74639955
67EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.74450049
68STAT4_19710469_ChIP-ChIP_TH1__Mouse1.74351758
69KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.73057667
70TCF4_18268006_ChIP-ChIP_LS174T_Human1.72853859
71STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.72630672
72KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.70957791
73FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.68179133
74KDM2B_26808549_Chip-Seq_DND41_Human1.67787596
75SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.67631811
76LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.65891457
77FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.64506927
78RUNX_20019798_ChIP-Seq_JUKART_Human1.62982931
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62605266
80MYB_26560356_Chip-Seq_TH1_Human1.61428079
81CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.60083623
82PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.59506141
83CTNNB1_20460455_ChIP-Seq_HCT116_Human1.58589508
84STAT6_21828071_ChIP-Seq_BEAS2B_Human1.58555784
85PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.57516822
86TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.56638387
87HNF4A_19822575_ChIP-Seq_HepG2_Human1.55552635
88PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.53137818
89KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.52289922
90KDM2B_26808549_Chip-Seq_SUP-B15_Human1.50758789
91CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.50030493
92ATF3_27146783_Chip-Seq_COLON_Human1.49509798
93RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48983161
94ZNF263_19887448_ChIP-Seq_K562_Human1.42253108
95KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.40783077
96HIF1A_21447827_ChIP-Seq_MCF-7_Human1.40568548
97SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.39437232
98CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.38377999
99GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.38150276
100BCOR_27268052_Chip-Seq_Bcells_Human1.37742878
101PU_27001747_Chip-Seq_BMDM_Mouse1.36702002
102ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.36575149
103NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.36236699
104ESR2_21235772_ChIP-Seq_MCF-7_Human1.35761842
105FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.34453594
106RACK7_27058665_Chip-Seq_MCF-7_Human1.34026972
107NCOR1_26117541_ChIP-Seq_K562_Human1.33846495
108IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.33057181
109ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.32307321
110TP53_16413492_ChIP-PET_HCT116_Human1.32125358
111FOXA2_19822575_ChIP-Seq_HepG2_Human1.30137431
112CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29116057
113GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29038227
114MAF_26560356_Chip-Seq_TH2_Human1.27897562
115ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.26194982
116RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.25613293
117CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20699062
118TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20333874
119ELK3_25401928_ChIP-Seq_HUVEC_Human1.19816685
120ELF1_17652178_ChIP-ChIP_JURKAT_Human1.16996968
121EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15887230
122ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15849232
123SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15109582
124SPI1_20517297_ChIP-Seq_HL60_Human1.14144868
125EGR1_23403033_ChIP-Seq_LIVER_Mouse1.13399402
126CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12368312
127SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.10792471
128FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.10335017
129GATA2_19941826_ChIP-Seq_K562_Human1.10328410
130CREB1_26743006_Chip-Seq_LNCaP_Human1.09271491
131TCF3_18692474_ChIP-Seq_MEFs_Mouse1.09187830
132BCL6_27268052_Chip-Seq_Bcells_Human1.07576941
133CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06908467
134ELF5_23300383_ChIP-Seq_T47D_Human1.06667326
135GATA3_27048872_Chip-Seq_THYMUS_Human1.06507990
136TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06435315
137SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06298356
138SMAD3_21741376_ChIP-Seq_HESCs_Human1.06240213
139ELF1_20517297_ChIP-Seq_JURKAT_Human1.03793527
140GATA3_26560356_Chip-Seq_TH2_Human1.02843716
141NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.02216018
142RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02076554
143MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.00952602
144PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00003176
145BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98721184
146SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98630045
147ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97171956
148KDM2B_26808549_Chip-Seq_JURKAT_Human0.95906003
149POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95560183
150STAT1_17558387_ChIP-Seq_HELA_Human0.94989645
151FOXM1_26456572_ChIP-Seq_MCF-7_Human0.94303357
152P68_20966046_ChIP-Seq_HELA_Human0.94218710
153PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93770933
154EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.93313558
155PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91860012
156GATA1_26923725_Chip-Seq_HPCs_Mouse0.91092904
157SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90531562
158LXR_22292898_ChIP-Seq_THP-1_Human0.90339183
159* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90175499
160SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.89152193
161SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.89152193
162SOX9_24532713_ChIP-Seq_HFSC_Mouse0.87930696
163MYC_19829295_ChIP-Seq_ESCs_Human0.86815253
164CTCF_21964334_ChIP-Seq_BJAB-B_Human0.86795742
165* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.85960986
166KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.84804965
167SALL4_18804426_ChIP-ChIP_XEN_Mouse0.82042545
168TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.81626510
169IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.80728264
170TDRD3_21172665_ChIP-Seq_MCF-7_Human0.79779674
171NANOG_20526341_ChIP-Seq_ESCs_Human0.78583296
172BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.77662601
173GATA3_24758297_ChIP-Seq_MCF-7_Human0.77415988
174PHF8_20622854_ChIP-Seq_HELA_Human0.77061396
175TP63_22573176_ChIP-Seq_HFKS_Human0.76738073
176THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.75031774
177P63_26484246_Chip-Seq_KERATINOCYTES_Human0.74638933
178FOXA1_25552417_ChIP-Seq_VCAP_Human0.73883663
179CLOCK_20551151_ChIP-Seq_293T_Human0.73126577
180BCAT_22108803_ChIP-Seq_LS180_Human0.72776929
181FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.72266698
182GATA2_22383799_ChIP-Seq_G1ME_Mouse0.71950965
183JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71283560
184* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.71164448
185CTCF_27219007_Chip-Seq_Bcells_Human0.68533884
186TCF3_18692474_ChIP-Seq_MESCs_Mouse0.66914525
187OCT4_18692474_ChIP-Seq_MEFs_Mouse0.66708218
188SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.64858219
189ESR1_15608294_ChIP-ChIP_MCF-7_Human0.63661527

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis9.01845862
2MP0001666_abnormal_nutrient_absorption5.05919199
3MP0003303_peritoneal_inflammation4.48373551
4MP0010234_abnormal_vibrissa_follicle4.24363536
5MP0000462_abnormal_digestive_system4.12814795
6MP0002139_abnormal_hepatobiliary_system4.04813885
7MP0009785_altered_susceptibility_to3.75611705
8MP0009840_abnormal_foam_cell3.61272253
9MP0003436_decreased_susceptibility_to3.53935807
10MP0005085_abnormal_gallbladder_physiolo3.50949755
11MP0009278_abnormal_bone_marrow3.43233732
12MP0004264_abnormal_extraembryonic_tissu3.32405178
13MP0009379_abnormal_foot_pigmentation3.18685523
14MP0002419_abnormal_innate_immunity3.14915784
15MP0005025_abnormal_response_to3.11530681
16MP0003300_gastrointestinal_ulcer3.08384901
17MP0008004_abnormal_stomach_pH2.87215573
18MP0003866_abnormal_defecation2.74419366
19MP0005397_hematopoietic_system_phenotyp2.71201459
20MP0001545_abnormal_hematopoietic_system2.71201459
21MP0005083_abnormal_biliary_tract2.67220610
22MP0003252_abnormal_bile_duct2.66244907
23MP0003183_abnormal_peptide_metabolism2.64892226
24MP0000537_abnormal_urethra_morphology2.64177841
25MP0005464_abnormal_platelet_physiology2.58774633
26MP0003724_increased_susceptibility_to2.58404313
27MP0001663_abnormal_digestive_system2.33837185
28MP0010329_abnormal_lipoprotein_level2.29978726
29MP0001835_abnormal_antigen_presentation2.28460541
30MP0010155_abnormal_intestine_physiology2.24712865
31MP0005365_abnormal_bile_salt2.24678593
32MP0005381_digestive/alimentary_phenotyp2.23157415
33MP0000490_abnormal_crypts_of2.22948941
34MP0003172_abnormal_lysosome_physiology2.21433256
35MP0010352_gastrointestinal_tract_polyps2.17799028
36MP0003828_pulmonary_edema2.13337766
37MP0000685_abnormal_immune_system2.02856053
38MP0001664_abnormal_digestion1.97963283
39MP0005000_abnormal_immune_tolerance1.95974640
40MP0002420_abnormal_adaptive_immunity1.95908898
41MP0008260_abnormal_autophagy1.95856098
42MP0008875_abnormal_xenobiotic_pharmacok1.94800958
43MP0004019_abnormal_vitamin_homeostasis1.93804726
44MP0002822_catalepsy1.92871547
45MP0001819_abnormal_immune_cell1.92232933
46MP0001873_stomach_inflammation1.86688527
47MP0000477_abnormal_intestine_morphology1.85518498
48MP0002398_abnormal_bone_marrow1.84691216
49MP0003045_fibrosis1.78435289
50MP0000538_abnormal_urinary_bladder1.76265494
51MP0002452_abnormal_antigen_presenting1.75199984
52MP0001533_abnormal_skeleton_physiology1.73562172
53MP0001790_abnormal_immune_system1.71428179
54MP0005387_immune_system_phenotype1.71428179
55MP0002148_abnormal_hypersensitivity_rea1.68600797
56MP0000465_gastrointestinal_hemorrhage1.66945313
57MP0001800_abnormal_humoral_immune1.66091800
58MP0002405_respiratory_system_inflammati1.64433733
59MP0002723_abnormal_immune_serum1.63477136
60MP0002722_abnormal_immune_system1.61212078
61MP0004043_abnormal_pH_regulation1.60901349
62MP0000689_abnormal_spleen_morphology1.58246196
63MP0009764_decreased_sensitivity_to1.54843939
64MP0005058_abnormal_lysosome_morphology1.54822956
65MP0001851_eye_inflammation1.52781719
66MP0001845_abnormal_inflammatory_respons1.51852194
67MP0003075_altered_response_to1.50538054
68MP0004808_abnormal_hematopoietic_stem1.49415542
69MP0000716_abnormal_immune_system1.48195597
70MP0004147_increased_porphyrin_level1.47419478
71MP0002138_abnormal_hepatobiliary_system1.46706666
72MP0002166_altered_tumor_susceptibility1.44962426
73MP0002429_abnormal_blood_cell1.44612929
74MP0009333_abnormal_splenocyte_physiolog1.43323761
75MP0005076_abnormal_cell_differentiation1.41983430
76MP0003787_abnormal_imprinting1.37565731
77MP0005084_abnormal_gallbladder_morpholo1.37034142
78MP0003693_abnormal_embryo_hatching1.35479569
79MP0008872_abnormal_physiological_respon1.30036754
80MP0002254_reproductive_system_inflammat1.29420527
81MP0002396_abnormal_hematopoietic_system1.28982628
82MP0002089_abnormal_postnatal_growth/wei1.28357718
83MP0006082_CNS_inflammation1.26064597
84MP0002163_abnormal_gland_morphology1.25380677
85MP0003123_paternal_imprinting1.25025712
86MP0002277_abnormal_respiratory_mucosa1.22194007
87MP0002796_impaired_skin_barrier1.21707356
88MP0005671_abnormal_response_to1.19574617
89MP0000613_abnormal_salivary_gland1.14458570
90MP0001485_abnormal_pinna_reflex1.12466609
91MP0005448_abnormal_energy_balance1.12170710
92MP0001853_heart_inflammation1.10797623
93MP0000566_synostosis1.09478083
94MP0003119_abnormal_digestive_system1.09220228
95MP0000703_abnormal_thymus_morphology1.08872221
96MP0005164_abnormal_response_to1.08182923
97MP0003763_abnormal_thymus_physiology1.07999110
98MP0003705_abnormal_hypodermis_morpholog1.06867106
99MP0009780_abnormal_chondrocyte_physiolo1.06351259
100MP0006054_spinal_hemorrhage1.05656882
101MP0008469_abnormal_protein_level1.04442587
102MP0005174_abnormal_tail_pigmentation1.02990274
103MP0003806_abnormal_nucleotide_metabolis1.02514870
104MP0004185_abnormal_adipocyte_glucose1.01851728
105MP0004883_abnormal_blood_vessel0.98721011
106MP0009763_increased_sensitivity_to0.97029888
107MP0000343_altered_response_to0.96981633
108MP0009765_abnormal_xenobiotic_induced0.96940372
109MP0009643_abnormal_urine_homeostasis0.96892453
110MP0003566_abnormal_cell_adhesion0.94358241
111MP0001849_ear_inflammation0.93762633
112MP0005332_abnormal_amino_acid0.91999931
113MP0009931_abnormal_skin_appearance0.90239915
114MP0009053_abnormal_anal_canal0.89068669
115MP0002132_abnormal_respiratory_system0.88589544
116MP0002006_tumorigenesis0.83396093
117MP0000470_abnormal_stomach_morphology0.83275353
118MP0000858_altered_metastatic_potential0.82969691
119MP0003221_abnormal_cardiomyocyte_apopto0.81023483
120MP0003453_abnormal_keratinocyte_physiol0.80655522
121MP0009697_abnormal_copulation0.80353229
122MP0002998_abnormal_bone_remodeling0.79997838
123MP0010678_abnormal_skin_adnexa0.79231374
124MP0004270_analgesia0.77796554
125MP0002098_abnormal_vibrissa_morphology0.77781253
126MP0002118_abnormal_lipid_homeostasis0.77456234
127MP0003795_abnormal_bone_structure0.76438772
128MP0009384_cardiac_valve_regurgitation0.75630839
129MP0005377_hearing/vestibular/ear_phenot0.74788927
130MP0003878_abnormal_ear_physiology0.74788927
131MP0000609_abnormal_liver_physiology0.74785084
132MP0001765_abnormal_ion_homeostasis0.71261484
133MP0003315_abnormal_perineum_morphology0.69550115
134MP0000678_abnormal_parathyroid_gland0.68944628
135MP0003718_maternal_effect0.68846866
136MP0005501_abnormal_skin_physiology0.68838510
137MP0000249_abnormal_blood_vessel0.67295473
138MP0000467_abnormal_esophagus_morphology0.67244380
139MP0004510_myositis0.66412405
140MP0005166_decreased_susceptibility_to0.64499020
141MP0003111_abnormal_nucleus_morphology0.64449665
142MP0000516_abnormal_urinary_system0.64159685
143MP0005367_renal/urinary_system_phenotyp0.64159685
144MP0005390_skeleton_phenotype0.63433212
145MP0002095_abnormal_skin_pigmentation0.62513605
146MP0004130_abnormal_muscle_cell0.62114129
147MP0002019_abnormal_tumor_incidence0.60373695
148MP0004947_skin_inflammation0.59874841
149MP0003950_abnormal_plasma_membrane0.59139132
150MP0001216_abnormal_epidermal_layer0.58935944
151MP0005075_abnormal_melanosome_morpholog0.58915432
152MP0005636_abnormal_mineral_homeostasis0.58478599
153MP0000604_amyloidosis0.58177085
154MP0000015_abnormal_ear_pigmentation0.57572140
155MP0004381_abnormal_hair_follicle0.57452459
156MP0010386_abnormal_urinary_bladder0.57166905
157MP0003690_abnormal_glial_cell0.56971589
158MP0009115_abnormal_fat_cell0.56901064
159MP0000598_abnormal_liver_morphology0.56659918
160MP0003868_abnormal_feces_composition0.56531081
161MP0002877_abnormal_melanocyte_morpholog0.55590597
162MP0005376_homeostasis/metabolism_phenot0.55072184
163MP0003448_altered_tumor_morphology0.53888377
164MP0005621_abnormal_cell_physiology0.53393329
165MP0005319_abnormal_enzyme/_coenzyme0.52768053
166MP0001764_abnormal_homeostasis0.51490944
167MP0005535_abnormal_body_temperature0.51366760
168MP0005408_hypopigmentation0.50557153
169MP0002876_abnormal_thyroid_physiology0.49203542
170MP0005379_endocrine/exocrine_gland_phen0.48467248
171MP0003283_abnormal_digestive_organ0.47435080
172MP0000579_abnormal_nail_morphology0.46921366
173MP0003191_abnormal_cellular_cholesterol0.46264463
174MP0005167_abnormal_blood-brain_barrier0.44886198
175MP0002136_abnormal_kidney_physiology0.43452577
176MP0002009_preneoplasia0.40452343
177MP0009642_abnormal_blood_homeostasis0.40033482
178MP0003879_abnormal_hair_cell0.38512241
179MP0005248_abnormal_Harderian_gland0.36633810
180MP0003656_abnormal_erythrocyte_physiolo0.36489653
181MP0003638_abnormal_response/metabolism_0.35415484
182MP0003938_abnormal_ear_development0.35255030
183MP0002060_abnormal_skin_morphology0.35157654

Predicted human phenotypes

RankGene SetZ-score
1Hypochromic anemia (HP:0001931)6.64821848
2Abnormality of glutamine family amino acid metabolism (HP:0010902)6.41241365
3Microcytic anemia (HP:0001935)5.75493325
4Malnutrition (HP:0004395)5.72246473
5Ventricular fibrillation (HP:0001663)5.67401166
6Acanthocytosis (HP:0001927)5.44161184
7Right ventricular cardiomyopathy (HP:0011663)5.37381485
8Polycythemia (HP:0001901)5.28105877
9Hypobetalipoproteinemia (HP:0003563)5.20746251
10Conjugated hyperbilirubinemia (HP:0002908)5.08685452
11Recurrent abscess formation (HP:0002722)4.95277151
12Congenital sensorineural hearing impairment (HP:0008527)4.89690608
13Rectal prolapse (HP:0002035)4.85565860
14Recurrent bacterial skin infections (HP:0005406)4.80183788
15Eczematoid dermatitis (HP:0000976)4.76444311
16Toxemia of pregnancy (HP:0100603)4.44765092
17Stomatitis (HP:0010280)4.36604440
18Paralysis (HP:0003470)4.25394659
19Abnormality of macrophages (HP:0004311)4.09479336
20Prolonged bleeding time (HP:0003010)4.08967543
21Cholelithiasis (HP:0001081)4.06214364
22Abnormality of urine glucose concentration (HP:0011016)3.92420430
23Glycosuria (HP:0003076)3.92420430
24Recurrent gram-negative bacterial infections (HP:0005420)3.84507344
25Abnormality of iron homeostasis (HP:0011031)3.78043489
26Gastrointestinal dysmotility (HP:0002579)3.67054593
27Abdominal distention (HP:0003270)3.65543708
28Fat malabsorption (HP:0002630)3.64875989
29Abnormal biliary tract morphology (HP:0012440)3.64292405
30Abnormal gallbladder morphology (HP:0012437)3.63904486
31Abnormality of proline metabolism (HP:0010907)3.54281546
32Hydroxyprolinuria (HP:0003080)3.54281546
33Chronic obstructive pulmonary disease (HP:0006510)3.53575826
34Obstructive lung disease (HP:0006536)3.53575826
35Pigmentary retinal degeneration (HP:0001146)3.52774559
36Diaphragmatic weakness (HP:0009113)3.50173476
37Intrahepatic cholestasis (HP:0001406)3.46824278
38Petechiae (HP:0000967)3.43624435
39Abnormality of the vitamin B12 metabolism (HP:0004341)3.31364147
40Autoimmune thrombocytopenia (HP:0001973)3.27144753
41Abnormality of monocarboxylic acid metabolism (HP:0010996)3.20393101
42Abnormality of transition element cation homeostasis (HP:0011030)3.18662750
43Male infertility (HP:0003251)3.14455639
44Epistaxis (HP:0000421)3.14064950
45Urticaria (HP:0001025)3.10673306
46Abnormality of vitamin B metabolism (HP:0004340)3.08192539
47Poikilocytosis (HP:0004447)3.06615972
48Widely patent fontanelles and sutures (HP:0004492)3.05744207
49Myositis (HP:0100614)3.04721040
50Syncope (HP:0001279)3.04684505
51Abnormal delayed hypersensitivity skin test (HP:0002963)2.99532991
52Chronic diarrhea (HP:0002028)2.98978180
53Elevated erythrocyte sedimentation rate (HP:0003565)2.98192468
54Abnormality of the gastric mucosa (HP:0004295)2.97136261
55Recurrent skin infections (HP:0001581)2.96937585
56Abnormality of chloride homeostasis (HP:0011422)2.96000351
57Hyperphosphaturia (HP:0003109)2.95939853
58Autoimmune hemolytic anemia (HP:0001890)2.91759283
59Mediastinal lymphadenopathy (HP:0100721)2.91462288
60Dehydration (HP:0001944)2.88923987
61Osteomyelitis (HP:0002754)2.87360905
62Pustule (HP:0200039)2.84976950
63Gingivitis (HP:0000230)2.84873493
64Recurrent fungal infections (HP:0002841)2.84405837
65Increased mean platelet volume (HP:0011877)2.82827039
66Systemic lupus erythematosus (HP:0002725)2.80177781
67Abnormality of vitamin metabolism (HP:0100508)2.77753306
68Gastrointestinal infarctions (HP:0005244)2.77668126
69Hypolipoproteinemia (HP:0010981)2.75158666
70Meningitis (HP:0001287)2.74073511
71Abnormal glucose tolerance (HP:0001952)2.71755024
72Wide cranial sutures (HP:0010537)2.66614307
73Prolonged QT interval (HP:0001657)2.64228648
74Amyloidosis (HP:0011034)2.63820753
75Abnormality of the gallbladder (HP:0005264)2.59178412
76Increased cerebral lipofuscin (HP:0011813)2.58150719
77Abnormality of small intestinal villus morphology (HP:0011472)2.57699303
78Villous atrophy (HP:0011473)2.57699303
79Gingival bleeding (HP:0000225)2.53536145
80Woolly hair (HP:0002224)2.53204410
81Uterine neoplasm (HP:0010784)2.51170918
82Nausea (HP:0002018)2.49880254
83Abnormal urine phosphate concentration (HP:0012599)2.49819652
84Pili torti (HP:0003777)2.49413680
85Abnormality of the fingertips (HP:0001211)2.49375571
86Cellulitis (HP:0100658)2.47587181
87Recurrent cutaneous fungal infections (HP:0011370)2.46777384
88Chronic mucocutaneous candidiasis (HP:0002728)2.46777384
89Increased serum ferritin (HP:0003281)2.45562475
90Cupped ribs (HP:0000887)2.44719529
91Abnormal platelet volume (HP:0011876)2.41413029
92Hepatosplenomegaly (HP:0001433)2.41134399
93Biliary tract neoplasm (HP:0100574)2.39968817
94Hyperglycinuria (HP:0003108)2.39744316
95Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.39007797
96Palpitations (HP:0001962)2.36802927
97Ventricular arrhythmia (HP:0004308)2.35952288
98Fragile skin (HP:0001030)2.35838239
99Keratoconjunctivitis sicca (HP:0001097)2.35324928
100Episodic fever (HP:0001954)2.34570772
101Late onset (HP:0003584)2.33769802
102Anorexia (HP:0002039)2.32736319
103Abnormal gallbladder physiology (HP:0012438)2.32011824
104Cholecystitis (HP:0001082)2.32011824
105Increased IgE level (HP:0003212)2.31550353
106Granulocytopenia (HP:0001913)2.30234490
107Mildly elevated creatine phosphokinase (HP:0008180)2.29869310
108Increased neuronal autofluorescent lipopigment (HP:0002074)2.29264683
109Nephrolithiasis (HP:0000787)2.28763997
110Menorrhagia (HP:0000132)2.25728806
111Thrombophlebitis (HP:0004418)2.24228350
112Orchitis (HP:0100796)2.23134340
113Thin bony cortex (HP:0002753)2.22661353
114Ankyloglossia (HP:0010296)2.22398477
115Hypercholesterolemia (HP:0003124)2.22296900
116Gastrointestinal carcinoma (HP:0002672)2.21280436
117Malignant gastrointestinal tract tumors (HP:0006749)2.21280436
118Micronodular cirrhosis (HP:0001413)2.20963882
119Recurrent viral infections (HP:0004429)2.20121286
120Impaired platelet aggregation (HP:0003540)2.19550315
121Abnormal platelet function (HP:0011869)2.19550315
122Microretrognathia (HP:0000308)2.19268974
123Hyperbilirubinemia (HP:0002904)2.18928734
124Abnormal hemoglobin (HP:0011902)2.18394646
125Purpura (HP:0000979)2.18299474
126Pallor (HP:0000980)2.18113593
127Optic neuritis (HP:0100653)2.17894281
128Retrobulbar optic neuritis (HP:0100654)2.17894281
129Abnormality of liposaccharide metabolism (HP:0010968)2.15560376
130Abnormality of glycosphingolipid metabolism (HP:0004343)2.15560376
131Abnormality of glycolipid metabolism (HP:0010969)2.15560376
132Hyperammonemia (HP:0001987)2.14056339
133Leukocytosis (HP:0001974)2.13540186
134Proximal tubulopathy (HP:0000114)2.13535186
135Keratoconjunctivitis (HP:0001096)2.12810909
136Abnormality of the right ventricle (HP:0001707)2.12386579
137Abnormality of aspartate family amino acid metabolism (HP:0010899)2.11893759
138Exocrine pancreatic insufficiency (HP:0001738)2.09746902
139Reticulocytosis (HP:0001923)2.09225692
140Vasculitis (HP:0002633)2.08861913
141Abnormality of purine metabolism (HP:0004352)2.06170968
142Hyperparathyroidism (HP:0000843)2.05544205
143Cutaneous photosensitivity (HP:0000992)2.05470044
144Hypertensive crisis (HP:0100735)2.05317617
145Posterior subcapsular cataract (HP:0007787)2.03490360
146Cheilitis (HP:0100825)2.02089222
147Paresthesia (HP:0003401)2.00238601
148Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.00153071
149Hypochromic microcytic anemia (HP:0004840)11.5801971
150Abnormality of the heme biosynthetic pathway (HP:0010472)10.9463815
151Ileus (HP:0002595)10.9262569
152Spontaneous hematomas (HP:0007420)1.98844347
153Hypercalciuria (HP:0002150)1.96411207
154Goiter (HP:0000853)1.95916308
155Encephalitis (HP:0002383)1.95761721
156Progressive sensorineural hearing impairment (HP:0000408)1.93596282
157Abnormality of sulfur amino acid metabolism (HP:0004339)1.92269559
158Neoplasm of the rectum (HP:0100743)1.91111172
159Progressive hearing impairment (HP:0001730)1.90608213
160Hemoptysis (HP:0002105)1.90603336
161Metabolic acidosis (HP:0001942)1.89485914
162Abnormal EKG (HP:0003115)1.88860275
163Hypophosphatemia (HP:0002148)1.88627148
164Pulmonary infiltrates (HP:0002113)1.87539243
165Neoplasm of the small intestine (HP:0100833)1.87143428
166Skin rash (HP:0000988)1.85814464
167Abnormality of the pericardium (HP:0001697)1.84478033
168Symptomatic seizures (HP:0011145)1.84028165
169Abnormality of the 1st metacarpal (HP:0010009)1.83953960
170Confusion (HP:0001289)1.82544490
171Chest pain (HP:0100749)1.82326670
172Potter facies (HP:0002009)1.82193752
173Facial shape deformation (HP:0011334)1.82193752
174Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.81409087
175Xanthomatosis (HP:0000991)1.81406216
176Premature loss of primary teeth (HP:0006323)1.81074138
177Hepatocellular carcinoma (HP:0001402)1.80286242
178Milia (HP:0001056)1.77965759
179Abnormality of reticulocytes (HP:0004312)1.77527774
180Abnormal hair laboratory examination (HP:0003328)1.77171599
181Splenomegaly (HP:0001744)1.76651614
182Hypoparathyroidism (HP:0000829)1.75463506
183Abnormality of T cell physiology (HP:0011840)1.75009294
184Skin ulcer (HP:0200042)1.74345025
185Slow saccadic eye movements (HP:0000514)1.72601042
186Azoospermia (HP:0000027)1.70065477
187Nonimmune hydrops fetalis (HP:0001790)1.69808744
188Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.68943597

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK29.54862296
2FRK5.82740512
3PRPF4B4.98184915
4MAP2K34.92854644
5PRKG24.35027354
6MST1R3.88437595
7MST43.27102895
8TAOK22.66466678
9NME12.52111691
10GRK62.36704848
11FES2.35942265
12BLK2.33775131
13EPHB22.31723060
14MAP2K62.21604714
15EPHA22.16221801
16TNK22.07395558
17RIPK12.07276145
18STK392.05830224
19IRAK42.03263782
20ZAP701.99108682
21SYK1.97461171
22MAP3K61.96745196
23NUAK11.94523961
24TEC1.91004238
25CLK11.83102809
26MAP2K21.83021948
27BTK1.79480300
28TYK21.73705767
29PIK3CG1.72719177
30MAP3K101.63536209
31MAP3K21.49917334
32TAOK31.45633902
33PTK61.43687109
34PBK1.26902394
35MET1.23645977
36MAPK121.23553850
37LYN1.23536817
38MAP3K141.20421506
39MAP3K111.19607791
40MAP3K51.19197142
41HCK1.17261487
42EIF2AK11.16131636
43JAK21.11165786
44MARK31.09670297
45TTK1.07319015
46ERBB21.05857627
47MAP3K131.05108982
48ERN11.03815747
49PTK2B1.02684026
50WNK41.00906298
51IRAK11.00301505
52MAP3K90.97007241
53CAMK1D0.96635986
54MAP4K10.91926810
55ITK0.89247841
56MAPK70.88512540
57OXSR10.86688380
58PIK3CA0.85584745
59IKBKE0.85502005
60TXK0.85228053
61TRPM70.85042642
62YES10.84816769
63TESK20.83218041
64MAP2K40.82041190
65MAP3K80.78684517
66MAPK110.75038414
67TESK10.73624093
68DMPK0.72644658
69PKN20.71761856
70TRIB30.71088376
71KIT0.71071878
72BMPR20.71016554
73PDK10.68516767
74EPHA30.68032382
75NME20.67937414
76IRAK20.67319765
77MAP3K10.65824975
78JAK10.65610286
79PTK20.64367146
80BMX0.64358683
81LCK0.64306661
82MARK20.62425136
83RIPK40.62019048
84RPS6KC10.58259226
85RPS6KL10.58259226
86PIM10.58209542
87PRKAA20.58013510
88RET0.57983467
89JAK30.57221952
90STK100.56574524
91HIPK20.56513671
92DAPK20.56265667
93KSR20.55247709
94MAPK40.55043124
95FER0.53782800
96PDK30.53599787
97PDK40.53599787
98AURKB0.53512280
99IKBKB0.52820542
100TAOK10.51190569
101SMG10.51167577
102SIK30.50961760
103DDR20.50658688
104LATS10.48958025
105PRKCI0.48716445
106CAMK1G0.48033545
107RPS6KA60.46779399
108EPHB10.46275125
109BRSK20.45956026
110CSF1R0.45377582
111IRAK30.44905981
112PRKAA10.44415434
113SGK30.43465946
114FYN0.43284717
115STK110.42602102
116TTN0.42361770
117ROCK10.41979419
118TGFBR20.41690348
119MYLK0.41517422
120CDK190.40477568
121MAP2K10.40071182
122STK40.38549371
123SIK20.38382744
124CAMK2B0.37439449
125MAP3K70.36908459
126MATK0.36801101
127WNK10.36755285
128DYRK1B0.35669588
129CSNK1E0.35140077
130SCYL20.34864398
131CAMK2G0.34236697
132GRK10.33782348
133KSR10.33042285
134MAPKAPK20.32648228
135PAK10.32097995
136KDR0.31475325
137RPS6KA20.30311104
138TBK10.28223864
139CAMK2D0.28120702
140PRKCA0.27620475
141PAK30.27484520
142CSNK1A10.26227531
143MAP3K30.25145568
144CSK0.24986796
145TLK10.24899632
146PRKACG0.24657920
147NEK10.23519146
148CDK120.23292885
149LRRK20.22800174
150PDPK10.21987580
151NEK20.20761391
152PDK20.20665448
153RPS6KB20.20612309
154SRC0.20253024
155PRKCQ0.19576481
156EEF2K0.19403864
157GSK3A0.18563947
158AKT20.18018174
159PAK40.17098981
160CDK60.17011776
161AKT30.16572097
162PRKCB0.15156514
163ERBB40.14950279
164FGR0.14526312
165ALK0.14495469
166PAK20.14158560
167RAF10.13927863

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049755.43269145
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.99751727
3Malaria_Homo sapiens_hsa051444.02553975
4Mineral absorption_Homo sapiens_hsa049783.52443186
5Nitrogen metabolism_Homo sapiens_hsa009103.33630336
6Asthma_Homo sapiens_hsa053103.26976530
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.05579273
8Renin-angiotensin system_Homo sapiens_hsa046143.03448623
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.92944290
10Vitamin digestion and absorption_Homo sapiens_hsa049772.87713549
11Carbohydrate digestion and absorption_Homo sapiens_hsa049732.50974928
12Osteoclast differentiation_Homo sapiens_hsa043802.41634071
13Galactose metabolism_Homo sapiens_hsa000522.40232713
14Fructose and mannose metabolism_Homo sapiens_hsa000512.35601554
15Staphylococcus aureus infection_Homo sapiens_hsa051502.27783083
16Leishmaniasis_Homo sapiens_hsa051402.24826246
17Folate biosynthesis_Homo sapiens_hsa007902.23362838
18Starch and sucrose metabolism_Homo sapiens_hsa005002.22281185
19Bile secretion_Homo sapiens_hsa049762.17216813
20Histidine metabolism_Homo sapiens_hsa003402.15113071
21Sulfur metabolism_Homo sapiens_hsa009202.03319042
22Pentose and glucuronate interconversions_Homo sapiens_hsa000402.02204608
23Other glycan degradation_Homo sapiens_hsa005112.00846280
24Tuberculosis_Homo sapiens_hsa051521.96502926
25Protein digestion and absorption_Homo sapiens_hsa049741.95671389
26Hematopoietic cell lineage_Homo sapiens_hsa046401.80321565
27Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.75138897
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.60915372
29Legionellosis_Homo sapiens_hsa051341.59527847
30B cell receptor signaling pathway_Homo sapiens_hsa046621.59478668
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.58656433
32Glutathione metabolism_Homo sapiens_hsa004801.58383230
33Non-small cell lung cancer_Homo sapiens_hsa052231.56051583
34Arginine biosynthesis_Homo sapiens_hsa002201.55513378
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.54650713
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.52340413
37Pentose phosphate pathway_Homo sapiens_hsa000301.46938453
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.46204892
39Caffeine metabolism_Homo sapiens_hsa002321.44927682
40Acute myeloid leukemia_Homo sapiens_hsa052211.44812100
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.38792303
42Glycerolipid metabolism_Homo sapiens_hsa005611.37989116
43Platelet activation_Homo sapiens_hsa046111.37813358
44Fatty acid degradation_Homo sapiens_hsa000711.37565186
45Toll-like receptor signaling pathway_Homo sapiens_hsa046201.37317865
46Chemokine signaling pathway_Homo sapiens_hsa040621.28370926
47Pancreatic cancer_Homo sapiens_hsa052121.24322816
48Tryptophan metabolism_Homo sapiens_hsa003801.22923000
49Pertussis_Homo sapiens_hsa051331.22634282
50Arginine and proline metabolism_Homo sapiens_hsa003301.19394979
51Chronic myeloid leukemia_Homo sapiens_hsa052201.19376244
52Influenza A_Homo sapiens_hsa051641.17911989
53Phagosome_Homo sapiens_hsa041451.16305871
54Hepatitis B_Homo sapiens_hsa051611.14453799
55Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.11624749
56Lysosome_Homo sapiens_hsa041421.10898202
57Regulation of autophagy_Homo sapiens_hsa041401.09934587
58Amoebiasis_Homo sapiens_hsa051461.09797582
59Glycosaminoglycan degradation_Homo sapiens_hsa005311.08284882
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.08110560
61Thyroid hormone synthesis_Homo sapiens_hsa049181.07303510
62Pancreatic secretion_Homo sapiens_hsa049721.06673952
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.06368476
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.06267996
65Collecting duct acid secretion_Homo sapiens_hsa049661.06138128
66NF-kappa B signaling pathway_Homo sapiens_hsa040641.03860012
67Jak-STAT signaling pathway_Homo sapiens_hsa046301.03536353
68Toxoplasmosis_Homo sapiens_hsa051451.03075580
69Pyruvate metabolism_Homo sapiens_hsa006201.01765422
70Renal cell carcinoma_Homo sapiens_hsa052111.01385972
71TNF signaling pathway_Homo sapiens_hsa046680.99696528
72Measles_Homo sapiens_hsa051620.98173145
73HIF-1 signaling pathway_Homo sapiens_hsa040660.97910030
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.97577160
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.93430570
76PPAR signaling pathway_Homo sapiens_hsa033200.92692076
77Carbon metabolism_Homo sapiens_hsa012000.92266356
78FoxO signaling pathway_Homo sapiens_hsa040680.91140539
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.89103765
80T cell receptor signaling pathway_Homo sapiens_hsa046600.87815875
81beta-Alanine metabolism_Homo sapiens_hsa004100.86449440
82Herpes simplex infection_Homo sapiens_hsa051680.85773044
83Gastric acid secretion_Homo sapiens_hsa049710.84743758
84Tight junction_Homo sapiens_hsa045300.81844884
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.80161836
86Chemical carcinogenesis_Homo sapiens_hsa052040.79287302
87Shigellosis_Homo sapiens_hsa051310.78056120
88Linoleic acid metabolism_Homo sapiens_hsa005910.77765519
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76980796
90* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75236551
91VEGF signaling pathway_Homo sapiens_hsa043700.74739781
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73919048
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.73278125
94Apoptosis_Homo sapiens_hsa042100.72508262
95ABC transporters_Homo sapiens_hsa020100.71593882
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69420696
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.68761792
98Choline metabolism in cancer_Homo sapiens_hsa052310.68197131
99Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.66621341
100Biosynthesis of amino acids_Homo sapiens_hsa012300.65544623
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64408930
1022-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63743862
103Arachidonic acid metabolism_Homo sapiens_hsa005900.62438695
104Thyroid cancer_Homo sapiens_hsa052160.61190680
105mTOR signaling pathway_Homo sapiens_hsa041500.60831489
106Prolactin signaling pathway_Homo sapiens_hsa049170.60536960
107Ribosome_Homo sapiens_hsa030100.60345437
108Rheumatoid arthritis_Homo sapiens_hsa053230.59999730
109Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57473385
110Lysine degradation_Homo sapiens_hsa003100.56090023
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56026087
112Intestinal immune network for IgA production_Homo sapiens_hsa046720.55981805
113Retinol metabolism_Homo sapiens_hsa008300.55619441
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.55568788
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55448915
116Primary immunodeficiency_Homo sapiens_hsa053400.55385320
117Sphingolipid metabolism_Homo sapiens_hsa006000.55380119
118Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55372122
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54997300
120Prostate cancer_Homo sapiens_hsa052150.53337662
121Phospholipase D signaling pathway_Homo sapiens_hsa040720.53214200
122Steroid biosynthesis_Homo sapiens_hsa001000.52491687
123Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50482525
124Graft-versus-host disease_Homo sapiens_hsa053320.49736358
125Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.49309310
126Leukocyte transendothelial migration_Homo sapiens_hsa046700.48827261
127Viral carcinogenesis_Homo sapiens_hsa052030.47870388
128Glioma_Homo sapiens_hsa052140.47401378
129Endocytosis_Homo sapiens_hsa041440.46521972
130Inositol phosphate metabolism_Homo sapiens_hsa005620.45907534
131Butanoate metabolism_Homo sapiens_hsa006500.45651618
132Insulin resistance_Homo sapiens_hsa049310.45552764
133Allograft rejection_Homo sapiens_hsa053300.45466677
134Ether lipid metabolism_Homo sapiens_hsa005650.44611806
135Dorso-ventral axis formation_Homo sapiens_hsa043200.43704031
136Insulin signaling pathway_Homo sapiens_hsa049100.42801842
137Notch signaling pathway_Homo sapiens_hsa043300.42103344
138Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41818787
139HTLV-I infection_Homo sapiens_hsa051660.41632159
140Vibrio cholerae infection_Homo sapiens_hsa051100.41601555
141Central carbon metabolism in cancer_Homo sapiens_hsa052300.41288413
142Autoimmune thyroid disease_Homo sapiens_hsa053200.41187779
143Epstein-Barr virus infection_Homo sapiens_hsa051690.40054969
144Alzheimers disease_Homo sapiens_hsa050100.39956965
145Salmonella infection_Homo sapiens_hsa051320.38481776
146Bladder cancer_Homo sapiens_hsa052190.35630356
147Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35307101
148Salivary secretion_Homo sapiens_hsa049700.34901332
149GnRH signaling pathway_Homo sapiens_hsa049120.34530441
150Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33504555
151Fatty acid metabolism_Homo sapiens_hsa012120.33277793
152Type II diabetes mellitus_Homo sapiens_hsa049300.32330928
153Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30954369
154Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.30029802
155Hepatitis C_Homo sapiens_hsa051600.29773194
156Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29170982
157Adherens junction_Homo sapiens_hsa045200.28947697
158Parkinsons disease_Homo sapiens_hsa050120.27456480
159Metabolic pathways_Homo sapiens_hsa011000.27237202
160Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26756487
161Insulin secretion_Homo sapiens_hsa049110.25487219
162Oxidative phosphorylation_Homo sapiens_hsa001900.24132173
163Selenocompound metabolism_Homo sapiens_hsa004500.23094669
164Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.17810204
165Endometrial cancer_Homo sapiens_hsa052130.16427544
166Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.14692934
167Phosphatidylinositol signaling system_Homo sapiens_hsa040700.14632652
168African trypanosomiasis_Homo sapiens_hsa051430.12399123
169Renin secretion_Homo sapiens_hsa049240.11661808
170Huntingtons disease_Homo sapiens_hsa050160.11136767
171NOD-like receptor signaling pathway_Homo sapiens_hsa046210.10950149
172Fatty acid elongation_Homo sapiens_hsa000620.10117031
173Steroid hormone biosynthesis_Homo sapiens_hsa001400.08296089
174Peroxisome_Homo sapiens_hsa041460.08281197
175Propanoate metabolism_Homo sapiens_hsa006400.08080813
176Fatty acid biosynthesis_Homo sapiens_hsa000610.07238537
177Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.05670470

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