DEFA5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several of the alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 5, is highly expressed in the secretory granules of Paneth cells of the ileum. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of guanylate cyclase activity (GO:0031282)8.07368759
2regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)7.65259517
3regulation of bile acid biosynthetic process (GO:0070857)7.52394759
4adhesion of symbiont to host cell (GO:0044650)6.84314807
5virion attachment to host cell (GO:0019062)6.84314807
6positive regulation of guanylate cyclase activity (GO:0031284)6.36858736
7bile acid and bile salt transport (GO:0015721)6.22817318
8vitamin A metabolic process (GO:0006776)6.06454852
9actin filament depolymerization (GO:0030042)6.01348202
10fat-soluble vitamin biosynthetic process (GO:0042362)5.87186610
11epoxygenase P450 pathway (GO:0019373)5.80397077
12fructose metabolic process (GO:0006000)5.78134243
13digestive system process (GO:0022600)5.54313236
14bundle of His cell to Purkinje myocyte communication (GO:0086069)5.53803336
15positive regulation of pseudopodium assembly (GO:0031274)5.45272329
16adhesion of symbiont to host (GO:0044406)5.43810898
17drug catabolic process (GO:0042737)5.09199995
18regulation of cGMP biosynthetic process (GO:0030826)4.93128258
19UDP-N-acetylglucosamine metabolic process (GO:0006047)4.92961870
20regulation of pseudopodium assembly (GO:0031272)4.90485459
21modified amino acid transport (GO:0072337)4.73409887
22glucose 6-phosphate metabolic process (GO:0051156)4.70409269
23response to hepatocyte growth factor (GO:0035728)4.68040807
24cellular response to hepatocyte growth factor stimulus (GO:0035729)4.68040807
25drinking behavior (GO:0042756)4.60853101
26membrane repolarization during cardiac muscle cell action potential (GO:0086013)4.60510250
27lipoprotein metabolic process (GO:0042157)4.59838402
28positive regulation of glycoprotein biosynthetic process (GO:0010560)4.56352755
29innate immune response in mucosa (GO:0002227)4.44637502
30plasma lipoprotein particle assembly (GO:0034377)4.32599176
31flavonoid metabolic process (GO:0009812)4.31289613
32very-low-density lipoprotein particle assembly (GO:0034379)4.30723600
33drug metabolic process (GO:0017144)4.28850908
34digestion (GO:0007586)4.27044180
35positive regulation of respiratory burst (GO:0060267)4.25255394
36intestinal epithelial cell development (GO:0060576)4.23261191
37peptide hormone processing (GO:0016486)4.18366966
38regulation of respiratory burst (GO:0060263)4.17235491
39protein-lipid complex assembly (GO:0065005)4.16475102
40antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.14164723
41hormone catabolic process (GO:0042447)4.14064825
42transepithelial transport (GO:0070633)4.13784534
43positive regulation of glycoprotein metabolic process (GO:1903020)4.11729156
44regulation of cGMP metabolic process (GO:0030823)4.10404571
45diacylglycerol metabolic process (GO:0046339)4.06750061
46membrane repolarization during action potential (GO:0086011)4.05970023
47thyroid hormone metabolic process (GO:0042403)4.02403488
48antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.98029506
49regulation of cholesterol homeostasis (GO:2000188)3.96882414
50regulation of vitamin metabolic process (GO:0030656)3.95587649
51renal system process involved in regulation of blood volume (GO:0001977)3.94564775
52regulation of cholesterol esterification (GO:0010872)3.93063639
53glycolipid catabolic process (GO:0019377)3.92152513
54antigen processing and presentation of endogenous antigen (GO:0019883)3.91923380
55* disruption of cells of other organism (GO:0044364)3.91805220
56* killing of cells of other organism (GO:0031640)3.91805220
57phospholipid efflux (GO:0033700)3.91373964
58regulation of dendritic cell antigen processing and presentation (GO:0002604)3.89633226
59lipoprotein transport (GO:0042953)3.85312593
60regulation of triglyceride catabolic process (GO:0010896)3.84749367
61response to nitric oxide (GO:0071731)3.84290640
62glycosphingolipid catabolic process (GO:0046479)3.82787402
633-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.74794491
64purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.74794491
65cellular response to nitric oxide (GO:0071732)3.74362566
66cholesterol homeostasis (GO:0042632)3.73932557
67triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.73922572
68ventricular cardiac muscle cell action potential (GO:0086005)3.72282527
69sterol homeostasis (GO:0055092)3.71479677
70positive regulation of cGMP biosynthetic process (GO:0030828)3.71469883
71regulation of cellular extravasation (GO:0002691)3.70732881
72* antimicrobial humoral response (GO:0019730)3.70270538
73mucosal immune response (GO:0002385)3.68635341
74filopodium assembly (GO:0046847)3.66501580
75NADH metabolic process (GO:0006734)3.66139498
76cholesterol transport (GO:0030301)3.66007271
77sterol transport (GO:0015918)3.66007271
78phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.65699697
79* antibacterial humoral response (GO:0019731)3.63539020
80sperm capacitation (GO:0048240)3.62199978
81cholesterol efflux (GO:0033344)3.60804932
82alkaloid metabolic process (GO:0009820)3.59667310
83arginine metabolic process (GO:0006525)3.58256834
84* defense response to fungus (GO:0050832)3.57867117
85regulation of systemic arterial blood pressure by hormone (GO:0001990)3.56470580
86regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.56470580
87endocrine process (GO:0050886)3.56470580
88glucuronate metabolic process (GO:0019585)3.55572253
89uronic acid metabolic process (GO:0006063)3.55572253
90sulfur compound transport (GO:0072348)3.54353202
91nucleoside diphosphate biosynthetic process (GO:0009133)3.52994774
92cellular glucuronidation (GO:0052695)3.52348514
93eosinophil chemotaxis (GO:0048245)3.51526366
94vitamin transmembrane transport (GO:0035461)3.51265796
95regulation of actin nucleation (GO:0051125)3.50333190
96maintenance of gastrointestinal epithelium (GO:0030277)3.48660398
97organ or tissue specific immune response (GO:0002251)3.47110602
98glomerular filtration (GO:0003094)3.46573742
99peptide catabolic process (GO:0043171)3.46445959
100homocysteine metabolic process (GO:0050667)3.45224119
101vitamin transport (GO:0051180)3.42842728
102positive regulation of triglyceride lipase activity (GO:0061365)3.37480772
103positive regulation of lipoprotein lipase activity (GO:0051006)3.37480772
104proline biosynthetic process (GO:0006561)3.36863767
105regulation of Golgi to plasma membrane protein transport (GO:0042996)3.36401084
106calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.33204948
107sulfate transmembrane transport (GO:1902358)3.32530444
108regulation of digestive system process (GO:0044058)3.31337599
109negative regulation of cholesterol transport (GO:0032375)3.27881079
110negative regulation of sterol transport (GO:0032372)3.27881079
111negative regulation of epidermal cell differentiation (GO:0045605)3.27659084
112urea cycle (GO:0000050)3.27304594
113urea metabolic process (GO:0019627)3.27304594
114positive regulation of Cdc42 GTPase activity (GO:0043089)3.27268952
115transcytosis (GO:0045056)3.25651126
116phospholipid scrambling (GO:0017121)3.24039127
117positive regulation of cGMP metabolic process (GO:0030825)3.23532366
118cellular response to reactive nitrogen species (GO:1902170)3.23195598
119glutamine family amino acid biosynthetic process (GO:0009084)3.21697224
120cGMP-mediated signaling (GO:0019934)3.19923954
121regulation of systemic arterial blood pressure (GO:0003073)3.17568401
122complement activation, classical pathway (GO:0006958)3.16566162
123regulation of viral release from host cell (GO:1902186)3.16557045
124positive regulation of digestive system process (GO:0060456)3.16026478
125fat-soluble vitamin metabolic process (GO:0006775)3.15131041
126renal filtration (GO:0097205)3.14617071
127O-glycan processing (GO:0016266)3.13835843
128eosinophil migration (GO:0072677)3.12923580
129midgut development (GO:0007494)3.12790817
130regulation of heart rate by cardiac conduction (GO:0086091)3.10674727
131regulation of chemokine secretion (GO:0090196)3.09890932
132phospholipid homeostasis (GO:0055091)3.07372668
133ceramide catabolic process (GO:0046514)3.07055650
134positive regulation of antigen processing and presentation (GO:0002579)3.06878937
135bicarbonate transport (GO:0015701)3.06866537
136low-density lipoprotein particle remodeling (GO:0034374)3.05910509
137striated muscle atrophy (GO:0014891)3.04026983
138ethanol metabolic process (GO:0006067)3.03378179
139leukotriene metabolic process (GO:0006691)3.03070496
140cGMP biosynthetic process (GO:0006182)3.01037683
141receptor guanylyl cyclase signaling pathway (GO:0007168)2.99523437
142GDP-mannose metabolic process (GO:0019673)2.98976244
143cobalamin metabolic process (GO:0009235)2.98287052
144phosphatidylserine acyl-chain remodeling (GO:0036150)2.97905086
145sexual reproduction (GO:0019953)2.94995899
146desmosome organization (GO:0002934)2.93461769
147cardiac conduction (GO:0061337)2.90427035
148nitrogen cycle metabolic process (GO:0071941)2.89699979
149negative regulation of keratinocyte proliferation (GO:0010839)2.88647248
150negative regulation of digestive system process (GO:0060457)2.88508374
151hepatocyte apoptotic process (GO:0097284)2.88390969
152intestinal cholesterol absorption (GO:0030299)12.2253164
153intestinal absorption (GO:0050892)12.0747199
154angiotensin maturation (GO:0002003)11.1543392

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CDX2_20551321_ChIP-Seq_CACO-2_Human6.17564902
2SOX2_27498859_Chip-Seq_STOMACH_Mouse3.98728245
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.66876167
4HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.55322250
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.48840036
6GATA4_25053715_ChIP-Seq_YYC3_Human3.32543531
7GATA6_25053715_ChIP-Seq_YYC3_Human3.31771070
8SOX2_20726797_ChIP-Seq_SW620_Human2.87264862
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.87125725
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.71449572
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.53393546
12LXR_22158963_ChIP-Seq_LIVER_Mouse2.39748319
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.25193366
14RXR_22158963_ChIP-Seq_LIVER_Mouse2.13772816
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.03996995
16CDX2_19796622_ChIP-Seq_MESCs_Mouse2.03904535
17TP63_17297297_ChIP-ChIP_HaCaT_Human10.2955846
18RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.97135557
19STAT6_21828071_ChIP-Seq_BEAS2B_Human1.95209277
20CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.91126239
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.90472753
22PPAR_26484153_Chip-Seq_NCI-H1993_Human1.89457758
23KLF5_25053715_ChIP-Seq_YYC3_Human1.85789401
24RUNX1_27514584_Chip-Seq_MCF-7_Human1.75840084
25SRY_22984422_ChIP-ChIP_TESTIS_Rat1.74985016
26TCF4_18268006_ChIP-ChIP_LS174T_Human1.74286034
27IRF8_21731497_ChIP-ChIP_J774_Mouse1.72733218
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71148710
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.68096013
30TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.64360868
31KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.60710808
32BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.58584851
33NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.56249815
34FOXO3_23340844_ChIP-Seq_DLD1_Human1.54816611
35ZNF263_19887448_ChIP-Seq_K562_Human1.54544243
36HNF4A_19822575_ChIP-Seq_HepG2_Human1.52596994
37ATF3_27146783_Chip-Seq_COLON_Human1.50958281
38RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.50921846
39RACK7_27058665_Chip-Seq_MCF-7_Human1.48796091
40NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.47149380
41KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.46468857
42AR_21909140_ChIP-Seq_LNCAP_Human1.42685718
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41926525
44FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.41256593
45SA1_27219007_Chip-Seq_Bcells_Human1.40345959
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.39999255
47TET1_21451524_ChIP-Seq_MESCs_Mouse1.38596238
48ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.35320788
49ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.33789929
50PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.31705675
51EGR1_19032775_ChIP-ChIP_M12_Human1.27601107
52CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.27437039
53SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26593680
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.26463296
55GATA1_26923725_Chip-Seq_HPCs_Mouse1.25355425
56FOXA2_19822575_ChIP-Seq_HepG2_Human1.24064842
57CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23504607
58GATA2_19941826_ChIP-Seq_K562_Human1.23007581
59ESR1_21235772_ChIP-Seq_MCF-7_Human1.22920901
60GATA1_22025678_ChIP-Seq_K562_Human1.22371113
61BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.21892351
62SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.20851440
63FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.20492086
64NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.19902235
65CTNNB1_20460455_ChIP-Seq_HCT116_Human1.19732956
66RARG_19884340_ChIP-ChIP_MEFs_Mouse1.18983311
67EGR1_23403033_ChIP-Seq_LIVER_Mouse1.18473854
68ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16810941
69SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15836866
70STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.14997139
71VDR_24763502_ChIP-Seq_THP-1_Human1.14954063
72ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14225702
73IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.12063745
74CREB1_26743006_Chip-Seq_LNCaP_Human1.11961067
75STAT1_17558387_ChIP-Seq_HELA_Human1.11267196
76TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10971756
77JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.09440004
78DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09169036
79HIF1A_21447827_ChIP-Seq_MCF-7_Human1.07333549
80SMAD3_21741376_ChIP-Seq_HESCs_Human1.06993200
81LXR_22292898_ChIP-Seq_THP-1_Human1.06310083
82STAT1_20625510_ChIP-Seq_HELA_Human1.05843693
83GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05450410
84TP53_16413492_ChIP-PET_HCT116_Human1.05044401
85SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.04493689
86EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01801409
87PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.00536304
88VDR_21846776_ChIP-Seq_THP-1_Human0.99898722
89SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99834875
90THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98846707
91CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98030175
92IKZF1_21737484_ChIP-ChIP_HCT116_Human0.97870894
93KAP1_22055183_ChIP-Seq_ESCs_Mouse0.97742245
94NANOG_20526341_ChIP-Seq_ESCs_Human0.96174881
95VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.95840526
96RAD21_21589869_ChIP-Seq_MESCs_Mouse0.95702249
97ELF5_23300383_ChIP-Seq_T47D_Human0.94983860
98NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.94633426
99DROSHA_22980978_ChIP-Seq_HELA_Human0.94493184
100CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94482365
101GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94114100
102GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.93680389
103AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.93451526
104KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93437952
105TCF3_18692474_ChIP-Seq_MEFs_Mouse0.93400033
106SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.93369954
107PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.91866334
108RXR_22108803_ChIP-Seq_LS180_Human0.91550857
109FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90417217
110IRF8_27001747_Chip-Seq_BMDM_Mouse0.89878188
111SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.89806336
112SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.89806336
113OCT4_18692474_ChIP-Seq_MEFs_Mouse0.89730071
114PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88026078
115JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87799602
116ELK3_25401928_ChIP-Seq_HUVEC_Human0.87442621
117NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.87238585
118TDRD3_21172665_ChIP-Seq_MCF-7_Human0.86894160
119CDX2_22108803_ChIP-Seq_LS180_Human0.86724102
120CTCF_27219007_Chip-Seq_ERYTHROID_Human0.86480359
121E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.85783071
122POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.84703166
123PHF8_20622854_ChIP-Seq_HELA_Human0.84496053
124P63_26484246_Chip-Seq_KERATINOCYTES_Human0.83298446
125TP63_22573176_ChIP-Seq_HFKS_Human0.83264518
126SA1_27219007_Chip-Seq_ERYTHROID_Human0.82397883
127ETS1_21867929_ChIP-Seq_TH2_Mouse0.81258066
128PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.80780043
129FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.80432857
130CTCF_20526341_ChIP-Seq_ESCs_Human0.80431763
131GATA1_19941826_ChIP-Seq_K562_Human0.79851535
132* MYC_19829295_ChIP-Seq_ESCs_Human0.79597601
133CTCF_27219007_Chip-Seq_Bcells_Human0.78799553
134FOXA1_25552417_ChIP-Seq_VCAP_Human0.78436836
135SOX9_24532713_ChIP-Seq_HFSC_Mouse0.77674493
136CLOCK_20551151_ChIP-Seq_293T_Human0.76987193
137BCOR_27268052_Chip-Seq_Bcells_Human0.75956630
138SALL4_18804426_ChIP-ChIP_XEN_Mouse0.74730204
139SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.73954224
140GATA2_21666600_ChIP-Seq_HMVEC_Human0.73412260
141BCL6_27268052_Chip-Seq_Bcells_Human0.73220062
142FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.71775300
143BCAT_22108803_ChIP-Seq_LS180_Human0.71774530
144GATA3_24758297_ChIP-Seq_MCF-7_Human0.70815500

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis9.98820807
2MP0001666_abnormal_nutrient_absorption5.57645941
3MP0005085_abnormal_gallbladder_physiolo3.97574680
4MP0010234_abnormal_vibrissa_follicle3.81181460
5MP0009840_abnormal_foam_cell3.79017848
6MP0000462_abnormal_digestive_system3.75621898
7MP0003183_abnormal_peptide_metabolism3.72823482
8MP0004264_abnormal_extraembryonic_tissu3.71830734
9MP0002139_abnormal_hepatobiliary_system3.46176979
10MP0009379_abnormal_foot_pigmentation3.07636559
11MP0003866_abnormal_defecation2.61878080
12MP0003300_gastrointestinal_ulcer2.45760533
13MP0003252_abnormal_bile_duct2.41006593
14MP0002822_catalepsy2.40566246
15MP0005365_abnormal_bile_salt2.37889939
16MP0010329_abnormal_lipoprotein_level2.29823922
17MP0008004_abnormal_stomach_pH2.20177031
18MP0000537_abnormal_urethra_morphology2.19625802
19MP0000538_abnormal_urinary_bladder2.10264266
20MP0005409_darkened_coat_color2.09025409
21MP0004019_abnormal_vitamin_homeostasis1.92967183
22MP0001873_stomach_inflammation1.91523849
23MP0005381_digestive/alimentary_phenotyp1.91398500
24MP0001663_abnormal_digestive_system1.90595102
25MP0008875_abnormal_xenobiotic_pharmacok1.85601651
26MP0005084_abnormal_gallbladder_morpholo1.84907462
27MP0010155_abnormal_intestine_physiology1.82602985
28MP0001664_abnormal_digestion1.82380656
29MP0004858_abnormal_nervous_system1.81957822
30MP0004147_increased_porphyrin_level1.66040606
31MP0005377_hearing/vestibular/ear_phenot1.63228024
32MP0003878_abnormal_ear_physiology1.63228024
33MP0000490_abnormal_crypts_of1.62429026
34MP0010352_gastrointestinal_tract_polyps1.58608182
35MP0002876_abnormal_thyroid_physiology1.56670287
36MP0000477_abnormal_intestine_morphology1.51125701
37MP0005448_abnormal_energy_balance1.41274282
38MP0004782_abnormal_surfactant_physiolog1.39702441
39MP0001188_hyperpigmentation1.33311596
40MP0002796_impaired_skin_barrier1.32692623
41MP0002254_reproductive_system_inflammat1.29725623
42MP0002089_abnormal_postnatal_growth/wei1.28915262
43MP0003705_abnormal_hypodermis_morpholog1.18854215
44MP0008872_abnormal_physiological_respon1.16884459
45MP0003724_increased_susceptibility_to1.16085215
46MP0009643_abnormal_urine_homeostasis1.15958299
47MP0001835_abnormal_antigen_presentation1.13119468
48MP0001845_abnormal_inflammatory_respons1.11584842
49MP0001501_abnormal_sleep_pattern1.07692608
50MP0005387_immune_system_phenotype1.04773285
51MP0001790_abnormal_immune_system1.04773285
52MP0005332_abnormal_amino_acid1.04303039
53MP0009785_altered_susceptibility_to1.03143855
54MP0003436_decreased_susceptibility_to1.02986064
55MP0002166_altered_tumor_susceptibility0.97349315
56MP0005025_abnormal_response_to0.96428856
57MP0001756_abnormal_urination0.95296285
58MP0005174_abnormal_tail_pigmentation0.94871043
59MP0000465_gastrointestinal_hemorrhage0.94309652
60MP0001849_ear_inflammation0.93751601
61MP0005535_abnormal_body_temperature0.93706057
62MP0002138_abnormal_hepatobiliary_system0.92445383
63MP0005670_abnormal_white_adipose0.92057905
64MP0000613_abnormal_salivary_gland0.89254399
65MP0003191_abnormal_cellular_cholesterol0.88805788
66MP0001485_abnormal_pinna_reflex0.87972662
67MP0003303_peritoneal_inflammation0.87911887
68MP0006054_spinal_hemorrhage0.87365449
69MP0004270_analgesia0.87174203
70MP0002118_abnormal_lipid_homeostasis0.86756619
71MP0002971_abnormal_brown_adipose0.86356733
72MP0000678_abnormal_parathyroid_gland0.86277667
73MP0010678_abnormal_skin_adnexa0.86170759
74MP0005501_abnormal_skin_physiology0.85778777
75MP0003329_amyloid_beta_deposits0.84355335
76MP0000609_abnormal_liver_physiology0.83659950
77MP0004043_abnormal_pH_regulation0.82126891
78MP0000604_amyloidosis0.81802138
79MP0004947_skin_inflammation0.80847443
80MP0002098_abnormal_vibrissa_morphology0.80735658
81MP0005671_abnormal_response_to0.80481343
82MP0008469_abnormal_protein_level0.79501200
83MP0006082_CNS_inflammation0.77646133
84MP0003453_abnormal_keratinocyte_physiol0.76228975
85MP0005166_decreased_susceptibility_to0.75154948
86MP0009764_decreased_sensitivity_to0.74190712
87MP0000230_abnormal_systemic_arterial0.73978700
88MP0003950_abnormal_plasma_membrane0.73910963
89MP0003806_abnormal_nucleotide_metabolis0.73172073
90MP0009115_abnormal_fat_cell0.72851641
91MP0001765_abnormal_ion_homeostasis0.72622638
92MP0003868_abnormal_feces_composition0.72125528
93MP0003938_abnormal_ear_development0.70742958
94MP0000685_abnormal_immune_system0.69479580
95MP0009384_cardiac_valve_regurgitation0.69267087
96MP0002148_abnormal_hypersensitivity_rea0.68683065
97MP0000249_abnormal_blood_vessel0.67007454
98MP0009333_abnormal_splenocyte_physiolog0.66528528
99MP0001216_abnormal_epidermal_layer0.66072553
100MP0001533_abnormal_skeleton_physiology0.65328607
101MP0001800_abnormal_humoral_immune0.64643643
102MP0003119_abnormal_digestive_system0.64131249
103MP0002277_abnormal_respiratory_mucosa0.63717194
104MP0005167_abnormal_blood-brain_barrier0.63080137
105MP0000470_abnormal_stomach_morphology0.63004297
106MP0005058_abnormal_lysosome_morphology0.62690513
107MP0003693_abnormal_embryo_hatching0.62329650
108MP0000467_abnormal_esophagus_morphology0.62276238
109MP0003315_abnormal_perineum_morphology0.61187952
110MP0010386_abnormal_urinary_bladder0.60835484
111MP0002396_abnormal_hematopoietic_system0.60404008
112MP0002006_tumorigenesis0.59399304
113MP0002896_abnormal_bone_mineralization0.58441893
114MP0000013_abnormal_adipose_tissue0.58367396
115MP0001764_abnormal_homeostasis0.57804189
116MP0005165_increased_susceptibility_to0.57736717
117MP0001881_abnormal_mammary_gland0.57420143
118MP0009053_abnormal_anal_canal0.56255542
119MP0005000_abnormal_immune_tolerance0.55748943
120MP0003879_abnormal_hair_cell0.55424543
121MP0005636_abnormal_mineral_homeostasis0.54764510
122MP0000566_synostosis0.53958811
123MP0002136_abnormal_kidney_physiology0.51647858
124MP0005310_abnormal_salivary_gland0.51296744
125MP0003718_maternal_effect0.51091986
126MP0005319_abnormal_enzyme/_coenzyme0.50017935
127MP0000579_abnormal_nail_morphology0.49729152
128MP0003283_abnormal_digestive_organ0.49296569
129MP0002060_abnormal_skin_morphology0.46867134
130MP0000516_abnormal_urinary_system0.46623042
131MP0005367_renal/urinary_system_phenotyp0.46623042
132MP0003787_abnormal_imprinting0.45472832
133MP0003638_abnormal_response/metabolism_0.44248944
134MP0009642_abnormal_blood_homeostasis0.43558833
135MP0002163_abnormal_gland_morphology0.43149246
136MP0010771_integument_phenotype0.42856338
137MP0009697_abnormal_copulation0.42262813
138MP0000377_abnormal_hair_follicle0.42205687
139MP0005584_abnormal_enzyme/coenzyme_acti0.40946204
140MP0005451_abnormal_body_composition0.38651475
141MP0009780_abnormal_chondrocyte_physiolo0.38518361
142MP0006138_congestive_heart_failure0.34404334
143MP0005023_abnormal_wound_healing0.31639888

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glutamine family amino acid metabolism (HP:0010902)7.62575634
2Malnutrition (HP:0004395)5.81089332
3Right ventricular cardiomyopathy (HP:0011663)5.64685178
4Acanthocytosis (HP:0001927)5.48699634
5Ventricular fibrillation (HP:0001663)5.29904137
6Conjugated hyperbilirubinemia (HP:0002908)5.29783454
7Systemic lupus erythematosus (HP:0002725)5.29033132
8Hypobetalipoproteinemia (HP:0003563)5.21593234
9Hydroxyprolinuria (HP:0003080)5.05326031
10Abnormality of proline metabolism (HP:0010907)5.05326031
11Congenital sensorineural hearing impairment (HP:0008527)4.84253594
12Fat malabsorption (HP:0002630)4.19650816
13Abnormality of the vitamin B12 metabolism (HP:0004341)4.00693268
14Widely patent fontanelles and sutures (HP:0004492)3.86133913
15Abnormality of vitamin B metabolism (HP:0004340)3.73243126
16Rectal prolapse (HP:0002035)3.63932887
17Pustule (HP:0200039)3.56653555
18Proximal tubulopathy (HP:0000114)3.48956147
19Gastrointestinal dysmotility (HP:0002579)3.46421469
20Hyperglycinuria (HP:0003108)3.42537038
21Intrahepatic cholestasis (HP:0001406)3.39198357
22Autoimmune thrombocytopenia (HP:0001973)3.37880780
23Pigmentary retinal degeneration (HP:0001146)3.34731745
24Abdominal distention (HP:0003270)3.30738336
25Decreased circulating renin level (HP:0003351)3.22879368
26Abnormality of vitamin metabolism (HP:0100508)3.21874752
27Abnormality of urine glucose concentration (HP:0011016)3.20938420
28Glycosuria (HP:0003076)3.20938420
29Poikilocytosis (HP:0004447)3.20079715
30Wide cranial sutures (HP:0010537)3.16298124
31Eczematoid dermatitis (HP:0000976)3.15593352
32Syncope (HP:0001279)3.15191326
33Chronic diarrhea (HP:0002028)3.11777231
34Abnormality of monocarboxylic acid metabolism (HP:0010996)3.09289865
35Alkalosis (HP:0001948)3.03357845
36Abnormal biliary tract morphology (HP:0012440)3.02354517
37Hypolipoproteinemia (HP:0010981)2.98705124
38Metabolic alkalosis (HP:0200114)2.97932473
39Abnormality of small intestinal villus morphology (HP:0011472)2.97530706
40Villous atrophy (HP:0011473)2.97530706
41Increased purine levels (HP:0004368)2.93619931
42Hyperuricemia (HP:0002149)2.93619931
43Goiter (HP:0000853)2.89959165
44Steatorrhea (HP:0002570)2.86710080
45Confusion (HP:0001289)2.86402147
46Hyperphosphaturia (HP:0003109)2.86099187
47Glomerulonephritis (HP:0000099)2.85048921
48Prolonged QT interval (HP:0001657)2.80799667
49Progressive hearing impairment (HP:0001730)2.76619159
50Abnormality of complement system (HP:0005339)2.75524049
51Pili torti (HP:0003777)2.75346109
52Increased mean platelet volume (HP:0011877)2.71442441
53Megaloblastic anemia (HP:0001889)2.71032716
54Nephrolithiasis (HP:0000787)2.69211298
55Abnormality of the gastric mucosa (HP:0004295)2.66981191
56Fragile skin (HP:0001030)2.65493464
57Abnormality of aspartate family amino acid metabolism (HP:0010899)2.63307727
58Urethral obstruction (HP:0000796)2.62863567
59Milia (HP:0001056)2.61219348
60Autoimmune hemolytic anemia (HP:0001890)2.60383954
61Complement deficiency (HP:0004431)2.59614451
62Hyperactive renin-angiotensin system (HP:0000841)2.55720492
63Dehydration (HP:0001944)2.55615556
64Potter facies (HP:0002009)2.55390438
65Facial shape deformation (HP:0011334)2.55390438
66Mildly elevated creatine phosphokinase (HP:0008180)2.54116621
67Abnormality of sulfur amino acid metabolism (HP:0004339)2.50489956
68Cupped ribs (HP:0000887)2.46296501
69Nephritis (HP:0000123)2.44886238
70Progressive sensorineural hearing impairment (HP:0000408)2.44588839
71Cheilitis (HP:0100825)2.42450239
72Abnormal urine phosphate concentration (HP:0012599)2.40833702
73Hemorrhage of the eye (HP:0011885)2.40771278
74Abnormality of renin-angiotensin system (HP:0000847)2.40627867
75Abnormal platelet volume (HP:0011876)2.36011013
76Woolly hair (HP:0002224)2.35626502
77Thin bony cortex (HP:0002753)2.35155962
78Hypotension (HP:0002615)2.34634716
79Palpitations (HP:0001962)2.32481804
80Abnormality of serine family amino acid metabolism (HP:0010894)2.32036309
81Abnormality of glycine metabolism (HP:0010895)2.32036309
82Enlarged epiphyses (HP:0010580)2.30207784
83Cerebral palsy (HP:0100021)2.27434484
84Biliary tract neoplasm (HP:0100574)2.27328461
85Abnormal hemoglobin (HP:0011902)2.26546427
86Ventricular arrhythmia (HP:0004308)2.25758104
87Hypercholesterolemia (HP:0003124)2.24425077
88Pancreatitis (HP:0001733)2.21853799
89Dicarboxylic aciduria (HP:0003215)2.20647559
90Abnormality of dicarboxylic acid metabolism (HP:0010995)2.20647559
91Delayed epiphyseal ossification (HP:0002663)2.19591455
92Focal segmental glomerulosclerosis (HP:0000097)2.18850562
93Gingivitis (HP:0000230)2.18667843
94Abnormality of purine metabolism (HP:0004352)2.18584273
95Hyperparathyroidism (HP:0000843)2.17669533
96Hyperphosphatemia (HP:0002905)2.16192641
97Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.13864303
98Abnormal glucose tolerance (HP:0001952)2.12788605
99Myopathic facies (HP:0002058)2.12013947
100Late onset (HP:0003584)2.10327881
101Growth hormone excess (HP:0000845)2.09675194
102Abnormality of the costochondral junction (HP:0000919)2.06810961
103Nausea (HP:0002018)2.04035999
104Reticulocytosis (HP:0001923)2.03340256
105Micronodular cirrhosis (HP:0001413)2.01938742
106Posterior subcapsular cataract (HP:0007787)2.00730934
107Male infertility (HP:0003251)2.00376329
108Symptomatic seizures (HP:0011145)2.00351642
109Ileus (HP:0002595)10.1288422
110Subcapsular cataract (HP:0000523)1.98447962
111Renal tubular acidosis (HP:0001947)1.98091944
112Protuberant abdomen (HP:0001538)1.96805333
113Hyperbilirubinemia (HP:0002904)1.96264517
114Epidermoid cyst (HP:0200040)1.95605247
115Hyperammonemia (HP:0001987)1.95559121
116Abnormality of pyrimidine metabolism (HP:0004353)1.93470703
117Gastrointestinal stroma tumor (HP:0100723)1.92323634
118Ankyloglossia (HP:0010296)1.92170404
119Gout (HP:0001997)1.91637401
120Abnormal EKG (HP:0003115)1.90723261
121Abnormality of magnesium homeostasis (HP:0004921)1.90449645
122Abnormal hair laboratory examination (HP:0003328)1.89006989
123Irritability (HP:0000737)1.88577512
124Abnormality of chloride homeostasis (HP:0011422)1.87664425
125Xanthomatosis (HP:0000991)1.87505646
126Emphysema (HP:0002097)1.83029995
127Multiple lipomas (HP:0001012)1.81857315
128Plantar hyperkeratosis (HP:0007556)1.80573916
129Uterine neoplasm (HP:0010784)1.80238149
130Abnormality of nucleobase metabolism (HP:0010932)1.79492977
131Hypophosphatemia (HP:0002148)1.78250672
132Paresthesia (HP:0003401)1.77762684
133Petechiae (HP:0000967)1.77125955
134Hypoalbuminemia (HP:0003073)1.76931243
135Abnormal albumin level (HP:0012116)1.76931243
136Premature loss of primary teeth (HP:0006323)1.76781097
137Macrocytic anemia (HP:0001972)1.76323667
138Skin rash (HP:0000988)1.75864446
139Metabolic acidosis (HP:0001942)1.75433216
140Increased muscle lipid content (HP:0009058)1.75172780
141Flat acetabular roof (HP:0003180)1.73674590
142Ventricular tachycardia (HP:0004756)1.73047690
143Abnormality of alkaline phosphatase activity (HP:0004379)1.72336023
144Abnormal enzyme/coenzyme activity (HP:0012379)1.72328485
145Hypocalcemia (HP:0002901)1.70111349
146Abnormality of reticulocytes (HP:0004312)1.69651234
147Segmental peripheral demyelination/remyelination (HP:0003481)1.68117966

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B7.31595564
2LMTK26.98084159
3FRK6.11973197
4MST44.68295501
5MST1R3.83056226
6NME13.68522589
7PRKG23.65028037
8GRK63.04029828
9EPHA22.90932031
10MAP2K62.44103455
11RIPK12.43954447
12MAP2K22.42997015
13TAOK32.36695244
14EIF2AK12.34796256
15EPHB22.30337505
16NUAK12.15565003
17TYK22.15145447
18EPHA31.89863182
19MAP3K101.88851111
20PTK61.71699355
21MAP3K21.65638526
22AKT31.42802074
23MET1.38836529
24ERN11.37959569
25DMPK1.30009815
26MAP3K91.23284395
27PRPF4B1.23191377
28MAP3K111.23083143
29PDK21.22607030
30ERBB21.17392429
31PBK1.17318027
32FGFR31.13615353
33STK241.08367379
34CDC42BPA1.06842182
35TNIK1.03593020
36STK391.02539957
37PIK3CA1.02116313
38TLK10.97847300
39TESK10.95247352
40NLK0.93015490
41MAP3K80.90071992
42TAOK10.89603385
43EPHA40.88504338
44TTK0.87524149
45STK100.85760012
46PTK20.85725987
47MAP3K10.83259458
48IKBKE0.78108915
49MAPK110.75572797
50JAK10.73250450
51KSR20.72290694
52IRAK30.69457350
53FER0.66826296
54MYLK0.66631069
55MAP2K10.65657371
56PRKCI0.65309772
57MATK0.64284498
58ZAP700.63932628
59DDR20.63808671
60IRAK10.63284641
61JAK30.61737856
62RIPK40.60302221
63PRKAA20.59857058
64EPHB10.59472839
65MAP4K10.59334947
66TBK10.59010151
67PRKCZ0.58973581
68JAK20.58112630
69AURKB0.56290953
70WNK40.54810751
71TRIB30.54163199
72KIT0.52423708
73BMPR20.49897835
74PIM10.49745590
75CSF1R0.49615087
76BMX0.48621392
77SMG10.46526703
78SYK0.46314356
79BTK0.46223942
80MAP3K30.45986651
81PDGFRA0.45903860
82ABL20.45286882
83RET0.44761466
84CAMK2B0.42583194
85MAP3K70.42324346
86MAP3K140.42137308
87CAMK2D0.41828243
88GRK10.41745766
89CDK190.40471045
90PAK40.40314509
91ITK0.38332352
92ROCK10.38036888
93MAPK150.37919205
94KDR0.36972610
95LYN0.36604215
96CAMK2G0.35300312
97CDK60.34662376
98IRAK40.34366312
99OXSR10.33267061
100YES10.32995363
101CSNK1E0.32797373
102CASK0.32341645
103LCK0.32337400
104LATS10.32128978
105TGFBR20.30720309
106PAK30.30314306
107CDK120.30122329
108FGFR40.30018276
109PAK10.29505262
110PRKCA0.29171072
111BCR0.28761697
112SRC0.26065006
113TEC0.26050401
114BLK0.26008234
115LRRK20.25290488
116PRKAA10.24821979
117RPS6KA20.24648906
118PDPK10.23714286
119PRKACG0.22096941
120CSNK1A10.21735679
121PRKCQ0.21723149
122SCYL20.18808041
123PRKCD0.18280956
124MAP3K120.18135305
125RAF10.16972977
126KSR10.16523823
127PAK20.16507725
128FYN0.14290704
129DYRK1B0.13615742
130RPS6KB20.13314768
131AKT20.12608058
132TESK20.12460187
133CSK0.11556428
134PDK10.10980197
135PRKCB0.10656697
136MAPKAPK20.10362815
137EEF2K0.09027856
138CDK50.08071340
139CHUK0.08049759
140STK110.07907763
141PRKG10.06781954
142RPS6KA40.06234285

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049756.24204884
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005245.36635776
3Renin-angiotensin system_Homo sapiens_hsa046144.56536483
4Vitamin digestion and absorption_Homo sapiens_hsa049773.59384555
5Mineral absorption_Homo sapiens_hsa049783.37864015
6Protein digestion and absorption_Homo sapiens_hsa049742.69807253
7Histidine metabolism_Homo sapiens_hsa003402.52529124
8Bile secretion_Homo sapiens_hsa049762.43826389
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.40390007
10Galactose metabolism_Homo sapiens_hsa000522.33459362
11Carbohydrate digestion and absorption_Homo sapiens_hsa049732.27074342
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.26278537
13Fructose and mannose metabolism_Homo sapiens_hsa000512.09700355
14Asthma_Homo sapiens_hsa053102.01401806
15Starch and sucrose metabolism_Homo sapiens_hsa005001.87951066
16Sulfur metabolism_Homo sapiens_hsa009201.75987224
17Nitrogen metabolism_Homo sapiens_hsa009101.74639741
18Caffeine metabolism_Homo sapiens_hsa002321.65296621
19Folate biosynthesis_Homo sapiens_hsa007901.58136933
20PPAR signaling pathway_Homo sapiens_hsa033201.55894790
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.55446600
22Glutathione metabolism_Homo sapiens_hsa004801.54517546
23Arginine and proline metabolism_Homo sapiens_hsa003301.50722956
24Glycerolipid metabolism_Homo sapiens_hsa005611.50147595
25Tryptophan metabolism_Homo sapiens_hsa003801.44971701
26Arginine biosynthesis_Homo sapiens_hsa002201.42868092
27Allograft rejection_Homo sapiens_hsa053301.42300986
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.41498925
29Thyroid hormone synthesis_Homo sapiens_hsa049181.34841109
30Autoimmune thyroid disease_Homo sapiens_hsa053201.34040684
31Graft-versus-host disease_Homo sapiens_hsa053321.27955146
32Fatty acid degradation_Homo sapiens_hsa000711.22951541
33Staphylococcus aureus infection_Homo sapiens_hsa051501.22903224
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.19536742
35Pentose and glucuronate interconversions_Homo sapiens_hsa000401.16774377
36Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.15730690
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.12378079
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.10245063
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.08304241
40Type I diabetes mellitus_Homo sapiens_hsa049401.03751742
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00273239
42Sphingolipid metabolism_Homo sapiens_hsa006000.97745700
43Pentose phosphate pathway_Homo sapiens_hsa000300.95812178
44Pyruvate metabolism_Homo sapiens_hsa006200.95290475
45Linoleic acid metabolism_Homo sapiens_hsa005910.92110069
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92092527
47Tight junction_Homo sapiens_hsa045300.90397776
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89729546
49Pancreatic secretion_Homo sapiens_hsa049720.88577099
50beta-Alanine metabolism_Homo sapiens_hsa004100.86943779
51Gastric acid secretion_Homo sapiens_hsa049710.80847024
52Antigen processing and presentation_Homo sapiens_hsa046120.78791245
53Phenylalanine metabolism_Homo sapiens_hsa003600.76770731
54Arachidonic acid metabolism_Homo sapiens_hsa005900.75307441
55ABC transporters_Homo sapiens_hsa020100.75301277
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.74880547
57Carbon metabolism_Homo sapiens_hsa012000.72591212
58Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.72205635
59Leishmaniasis_Homo sapiens_hsa051400.67091256
60Glycerophospholipid metabolism_Homo sapiens_hsa005640.65291381
612-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60982801
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.57072045
63Other glycan degradation_Homo sapiens_hsa005110.56132697
64Lysine degradation_Homo sapiens_hsa003100.54261367
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53981270
66Viral myocarditis_Homo sapiens_hsa054160.52333891
67Salmonella infection_Homo sapiens_hsa051320.52296437
68GnRH signaling pathway_Homo sapiens_hsa049120.51255333
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.46560119
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.46058876
71Alzheimers disease_Homo sapiens_hsa050100.44842642
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42034195
73Hepatitis C_Homo sapiens_hsa051600.41174443
74Sulfur relay system_Homo sapiens_hsa041220.41123041
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39699077
76Ether lipid metabolism_Homo sapiens_hsa005650.39573924
77Type II diabetes mellitus_Homo sapiens_hsa049300.36953873
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36837196
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.35798513
80Biosynthesis of amino acids_Homo sapiens_hsa012300.35635902
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.35423177
82Vibrio cholerae infection_Homo sapiens_hsa051100.34820631
83Bladder cancer_Homo sapiens_hsa052190.34054137
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33015490
85Parkinsons disease_Homo sapiens_hsa050120.32861536
86Retinol metabolism_Homo sapiens_hsa008300.32330850
87Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.32136430
88Toxoplasmosis_Homo sapiens_hsa051450.31879455
89Insulin secretion_Homo sapiens_hsa049110.30966261
90Adherens junction_Homo sapiens_hsa045200.30697591
91Butanoate metabolism_Homo sapiens_hsa006500.29918398
92African trypanosomiasis_Homo sapiens_hsa051430.29506836
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.29137116
94Tyrosine metabolism_Homo sapiens_hsa003500.28819158
95Ribosome_Homo sapiens_hsa030100.28077134
96Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.27179512
97Oxidative phosphorylation_Homo sapiens_hsa001900.26520746
98Hematopoietic cell lineage_Homo sapiens_hsa046400.26512767
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.25879255
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.25682368
101Salivary secretion_Homo sapiens_hsa049700.25300549
102Insulin resistance_Homo sapiens_hsa049310.25155480
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24517854
104Metabolic pathways_Homo sapiens_hsa011000.23940096
105NOD-like receptor signaling pathway_Homo sapiens_hsa046210.23110103
106Chemokine signaling pathway_Homo sapiens_hsa040620.22842808
107Phosphatidylinositol signaling system_Homo sapiens_hsa040700.22595484
108Chemical carcinogenesis_Homo sapiens_hsa052040.21759944
109Steroid biosynthesis_Homo sapiens_hsa001000.21452602
110Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.20790020
111Renin secretion_Homo sapiens_hsa049240.20364892
112Tuberculosis_Homo sapiens_hsa051520.19806568
113Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.18850584
114Pertussis_Homo sapiens_hsa051330.17832684
115Thyroid cancer_Homo sapiens_hsa052160.16982954
116Cocaine addiction_Homo sapiens_hsa050300.16038685
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.16003154
118Rheumatoid arthritis_Homo sapiens_hsa053230.14195925
119Huntingtons disease_Homo sapiens_hsa050160.13890696
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.12665142
121Fatty acid metabolism_Homo sapiens_hsa012120.12568731
122VEGF signaling pathway_Homo sapiens_hsa043700.12344883
123Peroxisome_Homo sapiens_hsa041460.12092033
124Primary bile acid biosynthesis_Homo sapiens_hsa001200.10503739
125Influenza A_Homo sapiens_hsa051640.10332461
126Primary immunodeficiency_Homo sapiens_hsa053400.09134768
127NF-kappa B signaling pathway_Homo sapiens_hsa040640.08156590
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.07078222
129Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.06396677
130Inositol phosphate metabolism_Homo sapiens_hsa005620.05381138
131Gap junction_Homo sapiens_hsa045400.04622916
132Glucagon signaling pathway_Homo sapiens_hsa049220.04514321
133Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.03805156
134Cardiac muscle contraction_Homo sapiens_hsa042600.03403822
135Fatty acid biosynthesis_Homo sapiens_hsa000610.01877119

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