DEFB103A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 103, an antibiotic peptide which is induced by bacteria and interferon gamma, and which displays antimicrobial activity against S. aureus, S. pyogenes, P. aeruginosa, E. coli, and C. albicans. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of transforming growth factor beta1 production (GO:0032908)9.81850613
2positive regulation of glomerulus development (GO:0090193)9.63940379
3regulation of cell proliferation involved in kidney development (GO:1901722)8.34362923
4positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)8.09988790
5regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)8.09988790
6defense response to Gram-negative bacterium (GO:0050829)8.07162355
7keratinocyte differentiation (GO:0030216)7.94584528
8molting cycle (GO:0042303)7.84547164
9hair cycle (GO:0042633)7.84547164
10positive regulation of p38MAPK cascade (GO:1900745)7.51721660
11regulation of interleukin-8 secretion (GO:2000482)7.37750320
12epidermal cell differentiation (GO:0009913)7.36381273
13positive regulation of T-helper 1 type immune response (GO:0002827)7.19133434
14multicellular organismal water homeostasis (GO:0050891)7.12862320
15defense response to fungus (GO:0050832)6.94357311
16antimicrobial humoral response (GO:0019730)6.63385642
17keratinocyte proliferation (GO:0043616)6.46740162
18regulation of glomerulus development (GO:0090192)6.43147728
19desmosome organization (GO:0002934)6.34971132
20water homeostasis (GO:0030104)5.96091116
21positive regulation of transforming growth factor beta production (GO:0071636)5.76047573
22regulation of p38MAPK cascade (GO:1900744)5.64211410
23epidermis development (GO:0008544)5.55916041
24regulation of MHC class I biosynthetic process (GO:0045343)5.41448069
25natural killer cell activation involved in immune response (GO:0002323)5.38209991
26activation of MAPKKK activity (GO:0000185)5.33789204
27negative regulation of interleukin-17 production (GO:0032700)5.30991858
28antibacterial humoral response (GO:0019731)5.21352895
29dendritic cell migration (GO:0036336)5.15551367
30regulation of T-helper 1 type immune response (GO:0002825)5.12425082
31nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)5.00843781
32peptide cross-linking (GO:0018149)4.97119301
33fatty acid elongation (GO:0030497)4.83159465
34response to fungus (GO:0009620)4.78227433
35negative regulation of meiotic cell cycle (GO:0051447)4.75054299
36positive regulation of meiotic cell cycle (GO:0051446)4.70781858
37long-chain fatty acid biosynthetic process (GO:0042759)4.49841931
38skin morphogenesis (GO:0043589)4.37051864
39positive regulation of cholesterol efflux (GO:0010875)4.32983480
40surfactant homeostasis (GO:0043129)4.21038846
41positive regulation of epidermis development (GO:0045684)4.18546517
42ectoderm development (GO:0007398)4.17076522
43bundle of His cell to Purkinje myocyte communication (GO:0086069)4.07938871
44phosphatidylserine acyl-chain remodeling (GO:0036150)4.05772080
45lipoxygenase pathway (GO:0019372)4.04240869
46positive regulation of sterol transport (GO:0032373)4.03673545
47positive regulation of cholesterol transport (GO:0032376)4.03673545
48chemical homeostasis within a tissue (GO:0048875)4.03240466
49intermediate filament cytoskeleton organization (GO:0045104)4.02087334
50phosphatidylinositol acyl-chain remodeling (GO:0036149)3.92085030
51intermediate filament-based process (GO:0045103)3.91555128
52negative regulation of interferon-gamma production (GO:0032689)3.88868244
53detection of bacterium (GO:0016045)3.86933599
54phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.82670816
55phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.81090791
56branching involved in labyrinthine layer morphogenesis (GO:0060670)3.80831673
57bile acid and bile salt transport (GO:0015721)3.78932979
58positive regulation of keratinocyte differentiation (GO:0045618)3.73975409
59regulation of hair cycle (GO:0042634)3.66766017
60regulation of transforming growth factor beta production (GO:0071634)3.66621718
61phospholipid efflux (GO:0033700)3.66315227
62defense response to Gram-positive bacterium (GO:0050830)3.61792909
63positive regulation of collagen biosynthetic process (GO:0032967)3.58374655
64positive regulation of vasculogenesis (GO:2001214)3.57473309
65intermediate filament organization (GO:0045109)3.56536678
66regulation of collagen biosynthetic process (GO:0032965)3.56144484
67positive regulation of interleukin-6 production (GO:0032755)3.51126210
68detection of other organism (GO:0098543)3.47123147
69C21-steroid hormone biosynthetic process (GO:0006700)3.44528278
70phosphatidylcholine acyl-chain remodeling (GO:0036151)3.41903779
71positive regulation of collagen metabolic process (GO:0010714)3.39398824
72linoleic acid metabolic process (GO:0043651)3.35883288
73ceramide biosynthetic process (GO:0046513)3.30467485
74positive regulation of epidermal cell differentiation (GO:0045606)3.29812745
75hair cell differentiation (GO:0035315)3.28177740
76negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.22756796
77protein K11-linked deubiquitination (GO:0035871)3.21884299
78cellular response to arsenic-containing substance (GO:0071243)3.19312022
79cellular protein complex localization (GO:0034629)3.13880527
80regulation of axon regeneration (GO:0048679)3.13836172
81regulation of neuron projection regeneration (GO:0070570)3.13836172
82regulation of natural killer cell differentiation (GO:0032823)3.04845112
83progesterone metabolic process (GO:0042448)3.01631201
84negative regulation of vascular permeability (GO:0043116)3.00475603
85keratinization (GO:0031424)27.8058454
86early endosome to late endosome transport (GO:0045022)2.91873180
87G-protein coupled receptor internalization (GO:0002031)2.90917128
88regulation of collagen metabolic process (GO:0010712)2.89689927
89regulation of interleukin-6 production (GO:0032675)2.86005529
90regulation of ruffle assembly (GO:1900027)2.84629028
91positive regulation of multicellular organismal metabolic process (GO:0044253)2.77250537
92regulation of epidermis development (GO:0045682)2.75905192
93regulation of cholesterol efflux (GO:0010874)2.75571868
94negative regulation of potassium ion transmembrane transport (GO:1901380)2.74903785
95transcription elongation from RNA polymerase I promoter (GO:0006362)2.66185433
96regulation of vasculogenesis (GO:2001212)2.65073244
97regulation of interleukin-17 production (GO:0032660)2.64531682
98establishment of skin barrier (GO:0061436)13.4482661
99regulation of water loss via skin (GO:0033561)11.5421804
100positive regulation of interleukin-8 secretion (GO:2000484)11.0298038

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human9.25772777
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse7.65088133
3TP63_17297297_ChIP-ChIP_HaCaT_Human7.61543595
4P63_26484246_Chip-Seq_KERATINOCYTES_Human4.60070081
5SMAD2_18955504_ChIP-ChIP_HaCaT_Human3.55092720
6SMAD3_18955504_ChIP-ChIP_HaCaT_Human3.55092720
7SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.21219244
8PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.89395924
9HIF1A_21447827_ChIP-Seq_MCF-7_Human2.72062569
10FOXO3_23340844_ChIP-Seq_DLD1_Human2.52858543
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.31856795
12ESR1_20079471_ChIP-ChIP_T-47D_Human2.30496699
13ATF3_23680149_ChIP-Seq_GBM1-GSC_Human2.25235284
14TP63_23658742_ChIP-Seq_EP156T_Human2.17322279
15SOX9_24532713_ChIP-Seq_HFSC_Mouse1.99248313
16GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.95742956
17JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.83122915
18CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.80733189
19ATF3_27146783_Chip-Seq_COLON_Human1.80047408
20AUTS2_25519132_ChIP-Seq_293T-REX_Human1.78640152
21RARG_19884340_ChIP-ChIP_MEFs_Mouse1.73860460
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.70968416
23TP53_18474530_ChIP-ChIP_U2OS_Human1.67807630
24RXR_22108803_ChIP-Seq_LS180_Human1.67244173
25JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.65539277
26FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.57008562
27TP63_22573176_ChIP-Seq_HFKS_Human1.52645197
28GATA6_21074721_ChIP-Seq_CACO-2_Human1.46801991
29ESR1_21235772_ChIP-Seq_MCF-7_Human1.46140888
30EGR1_19032775_ChIP-ChIP_M12_Human1.42859245
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.32793042
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.28791189
33SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.28722728
34CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.28619238
35CTCF_27219007_Chip-Seq_Bcells_Human1.28306073
36SOX2_20726797_ChIP-Seq_SW620_Human1.24997017
37KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24692022
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.21376566
39PPAR_26484153_Chip-Seq_NCI-H1993_Human1.21363594
40CJUN_26792858_Chip-Seq_BT549_Human1.19902603
41FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.18624417
42TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18115255
43TCF4_18268006_ChIP-ChIP_LS174T_Human1.16577126
44CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16549445
45TP53_16413492_ChIP-PET_HCT116_Human1.16528551
46P53_21459846_ChIP-Seq_SAOS-2_Human1.15875832
47TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15858963
48ERG_20517297_ChIP-Seq_VCAP_Human1.15493600
49ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11332169
50GATA3_24758297_ChIP-Seq_MCF-7_Human1.08514259
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.06539186
52HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03849182
53ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02557044
54KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02175715
55CTCF_20526341_ChIP-Seq_ESCs_Human1.01022737
56CLOCK_20551151_ChIP-Seq_293T_Human1.00992085
57PPARA_22158963_ChIP-Seq_LIVER_Mouse0.99193427
58CEBPB_22108803_ChIP-Seq_LS180_Human0.99019933
59UBF1/2_26484160_Chip-Seq_HMECs_Human0.97960810
60NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96431236
61NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96431236
62MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.95432946
63CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.93922161
64SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93062520
65P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.91452819
66GATA4_25053715_ChIP-Seq_YYC3_Human0.91114173
67ZNF217_24962896_ChIP-Seq_MCF-7_Human0.88378409
68KLF5_25053715_ChIP-Seq_YYC3_Human0.88217161
69NFIB_24661679_ChIP-Seq_LUNG_Mouse0.85121629
70SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.85027548
71YY1_22570637_ChIP-Seq_MALME-3M_Human0.82907612
72Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.81631137
73PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.79589317
74CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.79148862
75RUNX1_27514584_Chip-Seq_MCF-7_Human0.78994879
76RACK7_27058665_Chip-Seq_MCF-7_Human0.78324933
77ELF5_23300383_ChIP-Seq_T47D_Human0.75424300
78FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.74445732
79TCF3_18692474_ChIP-Seq_MESCs_Mouse0.74162047
80FOXH1_21741376_ChIP-Seq_ESCs_Human0.72755177
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.71910034
82POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.71910034
83THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.71207729
84ELK1_22589737_ChIP-Seq_MCF10A_Human0.71101603
85PCGF2_27294783_Chip-Seq_NPCs_Mouse0.70201124
86RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.69913415
87NOTCH1_21737748_ChIP-Seq_TLL_Human0.68025133
88GATA3_21867929_ChIP-Seq_TH1_Mouse0.66673260
89CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.66042210
90AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.65880736
91STAT6_21828071_ChIP-Seq_BEAS2B_Human0.65565891
92EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.64496635
93SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.64177990
94RBPJ_21746931_ChIP-Seq_IB4_Human0.63294491
95BRD4_25478319_ChIP-Seq_HGPS_Human0.62603696
96CTNNB1_20460455_ChIP-Seq_HCT116_Human0.61877073
97NCOR_22424771_ChIP-Seq_293T_Human0.61237600
98FOXA1_21572438_ChIP-Seq_LNCaP_Human0.59789741
99OCT4_20526341_ChIP-Seq_ESCs_Human0.59294506
100CDX2_22108803_ChIP-Seq_LS180_Human0.58921287

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier9.33172585
2MP0010234_abnormal_vibrissa_follicle8.57656852
3MP0000579_abnormal_nail_morphology5.39121716
4MP0003941_abnormal_skin_development5.36877797
5MP0005275_abnormal_skin_tensile5.29226327
6MP0005501_abnormal_skin_physiology5.14733121
7MP0003191_abnormal_cellular_cholesterol3.73747865
8MP0003950_abnormal_plasma_membrane3.69332193
9MP0010678_abnormal_skin_adnexa3.54701525
10MP0004381_abnormal_hair_follicle3.04186918
11MP0003453_abnormal_keratinocyte_physiol2.78743390
12MP0010771_integument_phenotype2.75347019
13MP0002098_abnormal_vibrissa_morphology2.58947715
14MP0001216_abnormal_epidermal_layer2.58236554
15MP0004947_skin_inflammation2.41659716
16MP0004782_abnormal_surfactant_physiolog2.38244609
17MP0000383_abnormal_hair_follicle2.24676003
18MP0002060_abnormal_skin_morphology2.22705778
19MP0003011_delayed_dark_adaptation2.08973833
20MP0000377_abnormal_hair_follicle2.01424504
21MP0000467_abnormal_esophagus_morphology1.63285608
22MP0000762_abnormal_tongue_morphology1.55886917
23MP0009931_abnormal_skin_appearance1.35440769
24MP0003656_abnormal_erythrocyte_physiolo1.35175026
25MP0000367_abnormal_coat/_hair1.29334170
26MP0004272_abnormal_basement_membrane1.26422025
27MP0003221_abnormal_cardiomyocyte_apopto1.21573384
28MP0003828_pulmonary_edema1.17116135
29MP0000427_abnormal_hair_cycle1.02598574
30MP0001784_abnormal_fluid_regulation0.96867118
31MP0004185_abnormal_adipocyte_glucose0.93110846
32MP0003705_abnormal_hypodermis_morpholog0.91302865
33MP0001191_abnormal_skin_condition0.91265574
34MP0004510_myositis0.86452901
35MP0008004_abnormal_stomach_pH0.84751325
36MP0003566_abnormal_cell_adhesion0.77620458
37MP0001243_abnormal_dermal_layer0.76029929
38MP0008057_abnormal_DNA_replication0.70184523
39MP0003806_abnormal_nucleotide_metabolis0.69609407
40MP0000647_abnormal_sebaceous_gland0.68976173
41MP0001177_atelectasis0.67323546
42MP0003878_abnormal_ear_physiology0.66209681
43MP0005377_hearing/vestibular/ear_phenot0.66209681
44MP0000749_muscle_degeneration0.65446375
45MP0004270_analgesia0.65225286
46MP0008058_abnormal_DNA_repair0.61251483
47MP0004885_abnormal_endolymph0.60443849
48MP0004264_abnormal_extraembryonic_tissu0.57743921
49MP0002136_abnormal_kidney_physiology0.57595800
50MP0001851_eye_inflammation0.57113638
51MP0001188_hyperpigmentation0.57091547
52MP0004043_abnormal_pH_regulation0.51139364
53MP0009053_abnormal_anal_canal0.50039686
54MP0008995_early_reproductive_senescence0.49213650
55MP0009840_abnormal_foam_cell0.48367146
56MP0002295_abnormal_pulmonary_circulatio0.48293775
57MP0005023_abnormal_wound_healing0.47109930
58MP0005409_darkened_coat_color0.46479465
59MP0008789_abnormal_olfactory_epithelium0.46004142
60MP0002133_abnormal_respiratory_system0.44559102
61MP0005388_respiratory_system_phenotype0.44559102
62MP0001340_abnormal_eyelid_morphology0.40019657
63MP0003755_abnormal_palate_morphology0.39574154
64MP0005375_adipose_tissue_phenotype0.38795214
65MP0010352_gastrointestinal_tract_polyps0.37451734
66MP0002234_abnormal_pharynx_morphology0.37060645
67MP0000566_synostosis0.36095684
68MP0002972_abnormal_cardiac_muscle0.35163747
69MP0010386_abnormal_urinary_bladder0.33702922
70MP0009672_abnormal_birth_weight0.33580504
71MP0004087_abnormal_muscle_fiber0.32923975
72MP0005075_abnormal_melanosome_morpholog0.31536517
73MP0003186_abnormal_redox_activity0.31212458
74MP0000003_abnormal_adipose_tissue0.29164380
75MP0001542_abnormal_bone_strength0.28849131
76MP0001529_abnormal_vocalization0.28360187
77MP0002697_abnormal_eye_size0.27996570
78MP0004197_abnormal_fetal_growth/weight/0.25781980
79MP0000465_gastrointestinal_hemorrhage0.25540320
80MP0001756_abnormal_urination0.24878370
81MP0004084_abnormal_cardiac_muscle0.24561126
82MP0001502_abnormal_circadian_rhythm0.24254296
83MP0002971_abnormal_brown_adipose0.24014806
84MP0000750_abnormal_muscle_regeneration0.23734093
85MP0000013_abnormal_adipose_tissue0.22109968
86MP0009333_abnormal_splenocyte_physiolog0.21107748
87MP0006072_abnormal_retinal_apoptosis0.19508879
88MP0005620_abnormal_muscle_contractility0.19258157
89MP0002095_abnormal_skin_pigmentation0.16618717
90MP0001299_abnormal_eye_distance/0.15511926
91MP0005666_abnormal_adipose_tissue0.14678977
92MP0000759_abnormal_skeletal_muscle0.14456526
93MP0008438_abnormal_cutaneous_collagen0.14428964
94MP0005394_taste/olfaction_phenotype0.13375987
95MP0005499_abnormal_olfactory_system0.13375987
96MP0009765_abnormal_xenobiotic_induced0.12000286
97MP0000432_abnormal_head_morphology0.11875573
98MP0001765_abnormal_ion_homeostasis0.11730427
99MP0002177_abnormal_outer_ear0.11451963
100MP0010630_abnormal_cardiac_muscle0.11262334

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)9.83106480
2Congenital ichthyosiform erythroderma (HP:0007431)9.18362241
3Palmoplantar hyperkeratosis (HP:0000972)7.89699119
4Oral leukoplakia (HP:0002745)7.60199752
5Palmar hyperkeratosis (HP:0010765)7.50474322
6Erythroderma (HP:0001019)6.91717921
7Plantar hyperkeratosis (HP:0007556)6.35920591
8Erythema (HP:0010783)6.30618721
9Thick nail (HP:0001805)5.99187890
10Follicular hyperkeratosis (HP:0007502)5.47706868
11Palmoplantar keratoderma (HP:0000982)4.71568539
12Ectropion (HP:0000656)4.66433698
13Corneal erosion (HP:0200020)4.59452301
14Onycholysis (HP:0001806)4.39409618
15Hypohidrosis (HP:0000966)4.23276651
16Gangrene (HP:0100758)4.03565447
17Hypotrichosis (HP:0001006)3.96912288
18Pustule (HP:0200039)3.90706594
19Fragile nails (HP:0001808)3.87391680
20Popliteal pterygium (HP:0009756)3.74898484
21Nail dystrophy (HP:0008404)3.56165431
22Lip pit (HP:0100267)3.51338892
23Hyperhidrosis (HP:0000975)3.50133157
24Corneal dystrophy (HP:0001131)3.44045991
25Pruritus (HP:0000989)3.32613474
26Sparse scalp hair (HP:0002209)3.17602727
27Laryngomalacia (HP:0001601)3.16725695
28Malignant hyperthermia (HP:0002047)2.91452414
29Abnormality of placental membranes (HP:0011409)2.91034022
30Amniotic constriction ring (HP:0009775)2.91034022
31Natal tooth (HP:0000695)2.88183385
32Lack of skin elasticity (HP:0100679)2.83836429
33Abnormality of small intestinal villus morphology (HP:0011472)2.81273224
34Villous atrophy (HP:0011473)2.81273224
35Distal lower limb muscle weakness (HP:0009053)2.79391008
36Dehydration (HP:0001944)2.77126155
37Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.60766947
38Hypergammaglobulinemia (HP:0010702)2.59556275
39Abnormal blistering of the skin (HP:0008066)2.58378358
40Brittle hair (HP:0002299)2.49713407
41Alopecia of scalp (HP:0002293)2.46654933
42Furrowed tongue (HP:0000221)2.38027603
43Right ventricular cardiomyopathy (HP:0011663)2.33078923
44Abnormality of the neuromuscular junction (HP:0003398)2.20448538
45Fatigable weakness (HP:0003473)2.20448538
46Hyporeflexia of lower limbs (HP:0002600)2.16725389
47Type 2 muscle fiber atrophy (HP:0003554)2.08840799
48Anonychia (HP:0001798)2.03968591
49Abnormality of the axillary hair (HP:0100134)2.02803427
50Abnormality of secondary sexual hair (HP:0009888)2.02803427
51Abnormality of nail color (HP:0100643)15.1532161
52Parakeratosis (HP:0001036)10.1581926
53Congenital nonbullous ichthyosiform erythroderma (HP:0007479)10.0844963
54Acanthosis nigricans (HP:0000956)1.98540863
55Muscle fiber atrophy (HP:0100295)1.95242731
56Advanced eruption of teeth (HP:0006288)1.92504271
57Abnormality of the salivary glands (HP:0010286)1.90418646
58Premature ovarian failure (HP:0008209)1.90029942
59Dry skin (HP:0000958)1.87398335
60Papilloma (HP:0012740)1.87097825
61Verrucae (HP:0200043)1.87097825
62Woolly hair (HP:0002224)1.85947344
63Sepsis (HP:0100806)1.85524522
64Dry hair (HP:0011359)1.81280162
65Pterygium (HP:0001059)1.80483397
66Eczematoid dermatitis (HP:0000976)1.78566436
67Urticaria (HP:0001025)1.77922370
68Carious teeth (HP:0000670)1.75322788
69Sparse eyelashes (HP:0000653)1.70441556
70Skin ulcer (HP:0200042)1.56269803
71Asthma (HP:0002099)1.53071044
72Epidermoid cyst (HP:0200040)1.52037262
73Milia (HP:0001056)1.49012950
74Areflexia of lower limbs (HP:0002522)1.48251711
75Everted lower lip vermilion (HP:0000232)1.42113192
76Abnormality of the fingernails (HP:0001231)1.41784844
77Blepharitis (HP:0000498)1.40148441
78EMG: neuropathic changes (HP:0003445)1.39257176
79Emphysema (HP:0002097)1.38997842
80Absent eyelashes (HP:0000561)1.33713764
81Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.32717030
82Weak cry (HP:0001612)1.24071687
83Absent hair (HP:0002298)1.22907768
84Gowers sign (HP:0003391)1.22548189
85Conjunctival hamartoma (HP:0100780)1.21968822
86Depressed nasal tip (HP:0000437)1.18944505
87Tetraparesis (HP:0002273)1.17702765
88Fine hair (HP:0002213)1.13281504
89Curly hair (HP:0002212)1.12985141
90Fetal akinesia sequence (HP:0001989)1.11741100
91Aplasia of the musculature (HP:0100854)1.10506966
92Malnutrition (HP:0004395)1.10421430
93Acanthocytosis (HP:0001927)1.10242778
94Akinesia (HP:0002304)1.07829399
95Easy fatigability (HP:0003388)1.05876905
96Abnormality of the labia majora (HP:0012881)1.05468041
97Distal lower limb amyotrophy (HP:0008944)1.04179791
98Cystic hygroma (HP:0000476)1.03688207
99Multifactorial inheritance (HP:0001426)0.97418155
100Sudden death (HP:0001699)0.97200382

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK243.51638971
2DYRK32.58410227
3MAP3K92.39785739
4ABL22.38317779
5MUSK2.26904415
6MAP3K122.13704701
7STK38L2.00824267
8EPHA212.8901363
9MAPK151.83221568
10PIM21.80366588
11TGFBR21.75754908
12IRAK21.75143560
13IRAK41.74291663
14NEK11.72598431
15MOS1.65368875
16IRAK31.63147331
17IRAK11.51795847
18AKT31.50221597
19TSSK61.43138853
20IKBKE1.38827539
21WNK11.22272476
22GRK71.19689938
23PKN11.14601232
24MAP3K51.08044172
25PDGFRB1.05395761
26ADRBK11.02420874
27CCNB10.97355259
28LATS10.95273257
29MAP2K10.94966777
30TBK10.92503654
31PDK20.89279237
32SGK4940.89083468
33SGK2230.89083468
34STK30.83343111
35MAP3K30.81465788
36LATS20.78470516
37TAOK20.77830902
38SGK20.73376831
39CDK60.71063608
40FGFR10.68452108
41TAOK10.65814423
42STK100.65062447
43DAPK30.64516301
44BMX0.61276380
45MTOR0.60481772
46FER0.60253512
47IKBKB0.59769045
48MAPK40.58168603
49SGK30.57932710
50PIK3CG0.54394534
51TAF10.51732864
52PAK20.50302863
53EIF2AK30.46670321
54NEK60.45576661
55PTK20.45392364
56GRK50.44791854
57BRAF0.44328667
58MST1R0.42584348
59MAP3K10.41932255
60CHUK0.41610204
61OBSCN0.37798897
62ABL10.36989759
63GSK3A0.35302681
64MET0.33368095
65MAP3K20.32144004
66ERBB30.31525122
67MAP3K110.31090169
68GRK10.28305434
69ILK0.27951214
70MYLK0.27637648
71HCK0.27423660
72MARK20.25884914
73PRKCI0.24509647
74DYRK1A0.24032907
75PRKCE0.23511395
76MAP3K60.22188774
77RPS6KA10.22050301
78DYRK1B0.21972000
79MAP3K140.21799736
80EIF2AK20.21043219
81MST40.20218290
82CAMK10.19500050
83VRK10.18388105
84PIM10.17079033
85PRPF4B0.14977659
86TGFBR10.14793388
87INSR0.13084402
88VRK20.12077258
89RPS6KL10.11743523
90RPS6KC10.11743523
91STK380.11648227
92MAPK80.10122783
93MAPK70.09505110
94RPS6KA60.09264122
95PLK20.08876267
96EPHB20.08402671
97CAMK2G0.08321624
98ROCK10.08003792
99CAMK2B0.07965136
100MAPK100.06959169

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005926.92408182
2Linoleic acid metabolism_Homo sapiens_hsa005915.49992270
3Ether lipid metabolism_Homo sapiens_hsa005654.09578833
4NOD-like receptor signaling pathway_Homo sapiens_hsa046214.06173279
5Sphingolipid metabolism_Homo sapiens_hsa006003.14900395
6Arachidonic acid metabolism_Homo sapiens_hsa005902.72410926
7Fatty acid elongation_Homo sapiens_hsa000622.48087182
8Circadian rhythm_Homo sapiens_hsa047102.44658040
9p53 signaling pathway_Homo sapiens_hsa041152.25577864
10RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.02518674
11Ovarian steroidogenesis_Homo sapiens_hsa049131.72403111
12Tight junction_Homo sapiens_hsa045301.71469739
13Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.66577866
14Long-term depression_Homo sapiens_hsa047301.51744986
15GnRH signaling pathway_Homo sapiens_hsa049121.39323240
16Fat digestion and absorption_Homo sapiens_hsa049751.38414331
17Vascular smooth muscle contraction_Homo sapiens_hsa042701.35400662
18Glycerophospholipid metabolism_Homo sapiens_hsa005641.34922670
19VEGF signaling pathway_Homo sapiens_hsa043701.32894912
20Collecting duct acid secretion_Homo sapiens_hsa049661.31400267
21Vibrio cholerae infection_Homo sapiens_hsa051101.15762080
22Endocytosis_Homo sapiens_hsa041441.11893473
23ABC transporters_Homo sapiens_hsa020101.08340102
24FoxO signaling pathway_Homo sapiens_hsa040681.06607221
25Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03688119
26Retinol metabolism_Homo sapiens_hsa008301.00977856
27Inositol phosphate metabolism_Homo sapiens_hsa005621.00531020
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.99104032
29MAPK signaling pathway_Homo sapiens_hsa040100.98646186
30Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.97581838
31Basal transcription factors_Homo sapiens_hsa030220.92117019
32Jak-STAT signaling pathway_Homo sapiens_hsa046300.81760072
33ErbB signaling pathway_Homo sapiens_hsa040120.81706512
34Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79218763
35RNA transport_Homo sapiens_hsa030130.78180507
36Ras signaling pathway_Homo sapiens_hsa040140.77703675
37Pancreatic secretion_Homo sapiens_hsa049720.77676012
38Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76730503
39Serotonergic synapse_Homo sapiens_hsa047260.76542483
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76067397
41Dorso-ventral axis formation_Homo sapiens_hsa043200.75529829
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71120291
43Sulfur metabolism_Homo sapiens_hsa009200.68276685
44Glutamatergic synapse_Homo sapiens_hsa047240.65065672
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62048349
46Renin secretion_Homo sapiens_hsa049240.61913866
47Choline metabolism in cancer_Homo sapiens_hsa052310.61018663
48TGF-beta signaling pathway_Homo sapiens_hsa043500.59926422
49Oxytocin signaling pathway_Homo sapiens_hsa049210.58780691
50Amoebiasis_Homo sapiens_hsa051460.58434481
51Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57992690
52Synaptic vesicle cycle_Homo sapiens_hsa047210.54755688
53Sphingolipid signaling pathway_Homo sapiens_hsa040710.54579148
54Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54474464
55Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52896643
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52684954
57Renin-angiotensin system_Homo sapiens_hsa046140.52634244
58Bladder cancer_Homo sapiens_hsa052190.52570378
59Hippo signaling pathway_Homo sapiens_hsa043900.51509966
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.50163619
61Adherens junction_Homo sapiens_hsa045200.49632566
62Hepatitis C_Homo sapiens_hsa051600.48972217
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.48429042
64Dilated cardiomyopathy_Homo sapiens_hsa054140.47539948
65Amphetamine addiction_Homo sapiens_hsa050310.47034628
66Prion diseases_Homo sapiens_hsa050200.46725255
67Mineral absorption_Homo sapiens_hsa049780.45938825
68Renal cell carcinoma_Homo sapiens_hsa052110.45347706
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.44281733
70Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43249032
71Legionellosis_Homo sapiens_hsa051340.42973000
72Toxoplasmosis_Homo sapiens_hsa051450.40988020
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39749491
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.37061955
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.36829719
76Platelet activation_Homo sapiens_hsa046110.35180638
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32176168
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.32135013
79Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.29284689
80Influenza A_Homo sapiens_hsa051640.29257455
81Apoptosis_Homo sapiens_hsa042100.29017224
82Salmonella infection_Homo sapiens_hsa051320.26780910
83MicroRNAs in cancer_Homo sapiens_hsa052060.26549008
84Calcium signaling pathway_Homo sapiens_hsa040200.26326361
85Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.24808686
86AMPK signaling pathway_Homo sapiens_hsa041520.24656045
87Glycerolipid metabolism_Homo sapiens_hsa005610.22988745
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.22417975
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.22317842
90Estrogen signaling pathway_Homo sapiens_hsa049150.22287644
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.22179073
92HIF-1 signaling pathway_Homo sapiens_hsa040660.21135192
93Caffeine metabolism_Homo sapiens_hsa002320.19953633
94Glucagon signaling pathway_Homo sapiens_hsa049220.19474011
95Shigellosis_Homo sapiens_hsa051310.19359497
96Salivary secretion_Homo sapiens_hsa049700.19218624
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.18283351
98Viral myocarditis_Homo sapiens_hsa054160.18263363
99TNF signaling pathway_Homo sapiens_hsa046680.17857043
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.16389234

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