DEFB103B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 103, which has broad spectrum antimicrobial activity and may play an important role in innate epithelial defense. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of humoral immune response (GO:0002922)9.50063851
2regulation of transforming growth factor beta1 production (GO:0032908)9.35693423
3positive regulation of glomerulus development (GO:0090193)9.11757131
4regulation of cell proliferation involved in kidney development (GO:1901722)7.84929621
5keratinocyte differentiation (GO:0030216)7.83088527
6defense response to Gram-negative bacterium (GO:0050829)7.76552482
7positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)7.69537811
8regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)7.69537811
9regulation of cellular amide metabolic process (GO:0034248)7.65251706
10molting cycle (GO:0042303)7.60217526
11hair cycle (GO:0042633)7.60217526
12epidermal cell differentiation (GO:0009913)7.22567233
13positive regulation of p38MAPK cascade (GO:1900745)7.19920185
14regulation of interleukin-8 secretion (GO:2000482)7.03095800
15multicellular organismal water homeostasis (GO:0050891)6.98736528
16positive regulation of T-helper 1 type immune response (GO:0002827)6.85837310
17defense response to fungus (GO:0050832)6.64674115
18antimicrobial humoral response (GO:0019730)6.38818453
19keratinocyte proliferation (GO:0043616)6.29629845
20desmosome organization (GO:0002934)6.13586604
21regulation of glomerulus development (GO:0090192)6.03705643
22water homeostasis (GO:0030104)5.84607112
23positive regulation of transforming growth factor beta production (GO:0071636)5.45221376
24epidermis development (GO:0008544)5.44369756
25regulation of p38MAPK cascade (GO:1900744)5.31355548
26positive regulation of response to biotic stimulus (GO:0002833)5.14202289
27negative regulation of interleukin-17 production (GO:0032700)5.13606115
28regulation of MHC class I biosynthetic process (GO:0045343)5.12517295
29activation of MAPKKK activity (GO:0000185)5.11741061
30natural killer cell activation involved in immune response (GO:0002323)5.11707553
31antibacterial humoral response (GO:0019731)5.00001644
32dendritic cell migration (GO:0036336)4.90022435
33peptide cross-linking (GO:0018149)4.89642532
34regulation of T-helper 1 type immune response (GO:0002825)4.88081405
35nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)4.78109318
36fatty acid elongation (GO:0030497)4.60364350
37response to fungus (GO:0009620)4.58188370
38negative regulation of meiotic cell cycle (GO:0051447)4.46832091
39positive regulation of meiotic cell cycle (GO:0051446)4.45454134
40long-chain fatty acid biosynthetic process (GO:0042759)4.37083920
41skin morphogenesis (GO:0043589)4.33033501
42positive regulation of cholesterol efflux (GO:0010875)4.20366918
43surfactant homeostasis (GO:0043129)4.12322284
44ectoderm development (GO:0007398)4.05268820
45positive regulation of epidermis development (GO:0045684)4.02732836
46lipoxygenase pathway (GO:0019372)3.96459489
47phosphatidylserine acyl-chain remodeling (GO:0036150)3.95000877
48chemical homeostasis within a tissue (GO:0048875)3.94298975
49intermediate filament cytoskeleton organization (GO:0045104)3.92457103
50positive regulation of cholesterol transport (GO:0032376)3.88746216
51positive regulation of sterol transport (GO:0032373)3.88746216
52intermediate filament-based process (GO:0045103)3.81408814
53phosphatidylinositol acyl-chain remodeling (GO:0036149)3.80960846
54detection of bacterium (GO:0016045)3.79608148
55negative regulation of interferon-gamma production (GO:0032689)3.78076054
56phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.71121969
57phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.70280881
58bundle of His cell to Purkinje myocyte communication (GO:0086069)3.67632244
59branching involved in labyrinthine layer morphogenesis (GO:0060670)3.65648069
60bile acid and bile salt transport (GO:0015721)3.59504441
61positive regulation of keratinocyte differentiation (GO:0045618)3.57606789
62phospholipid efflux (GO:0033700)3.56703640
63regulation of hair cycle (GO:0042634)3.50108920
64regulation of transforming growth factor beta production (GO:0071634)3.48294209
65intermediate filament organization (GO:0045109)3.46744846
66positive regulation of collagen biosynthetic process (GO:0032967)3.42228831
67regulation of collagen biosynthetic process (GO:0032965)3.41737328
68detection of other organism (GO:0098543)3.41169454
69defense response to Gram-positive bacterium (GO:0050830)3.39742697
70positive regulation of vasculogenesis (GO:2001214)3.39697390
71positive regulation of interleukin-6 production (GO:0032755)3.35747421
72phosphatidylcholine acyl-chain remodeling (GO:0036151)3.32880880
73linoleic acid metabolic process (GO:0043651)3.30757301
74C21-steroid hormone biosynthetic process (GO:0006700)3.27489119
75positive regulation of collagen metabolic process (GO:0010714)3.24113998
76hair cell differentiation (GO:0035315)3.20313438
77ceramide biosynthetic process (GO:0046513)3.18983680
78positive regulation of epidermal cell differentiation (GO:0045606)3.17411402
79cellular response to arsenic-containing substance (GO:0071243)3.11527580
80regulation of neuron projection regeneration (GO:0070570)3.07860847
81regulation of axon regeneration (GO:0048679)3.07860847
82cellular protein complex localization (GO:0034629)3.04347552
83keratinization (GO:0031424)26.9262283
84protein K11-linked deubiquitination (GO:0035871)2.98307887
85regulation of natural killer cell differentiation (GO:0032823)2.96840128
86negative regulation of vascular permeability (GO:0043116)2.92580643
87progesterone metabolic process (GO:0042448)2.87735878
88defense response to bacterium (GO:0042742)2.87225269
89early endosome to late endosome transport (GO:0045022)2.85564378
90negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.82438598
91regulation of collagen metabolic process (GO:0010712)2.78320476
92G-protein coupled receptor internalization (GO:0002031)2.75960187
93regulation of interleukin-6 production (GO:0032675)2.75549803
94regulation of ruffle assembly (GO:1900027)2.73574144
95regulation of cholesterol efflux (GO:0010874)2.67057874
96regulation of epidermis development (GO:0045682)2.65069723
97positive regulation of cellular amide metabolic process (GO:0034250)14.7708154
98establishment of skin barrier (GO:0061436)13.1506550
99regulation of water loss via skin (GO:0033561)11.3076056
100positive regulation of interleukin-8 secretion (GO:2000484)10.5001684

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human9.27270640
2TP63_17297297_ChIP-ChIP_HaCaT_Human7.95560199
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse7.69933701
4P63_26484246_Chip-Seq_KERATINOCYTES_Human4.61058533
5SMAD3_18955504_ChIP-ChIP_HaCaT_Human3.56454723
6SMAD2_18955504_ChIP-ChIP_HaCaT_Human3.56454723
7SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.29571313
8PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.94247074
9HIF1A_21447827_ChIP-Seq_MCF-7_Human2.70164655
10FOXO3_23340844_ChIP-Seq_DLD1_Human2.52505958
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.27789522
12ATF3_23680149_ChIP-Seq_GBM1-GSC_Human2.23503915
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.19425461
14TP63_23658742_ChIP-Seq_EP156T_Human2.17104963
15SOX9_24532713_ChIP-Seq_HFSC_Mouse2.00103513
16GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.96109349
17CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.83138626
18JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.83119254
19ATF3_27146783_Chip-Seq_COLON_Human1.81258623
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.77678270
21RARG_19884340_ChIP-ChIP_MEFs_Mouse1.76847889
22AUTS2_25519132_ChIP-Seq_293T-REX_Human1.70599165
23RXR_22108803_ChIP-Seq_LS180_Human1.66912525
24JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.66151040
25TP53_18474530_ChIP-ChIP_U2OS_Human1.63130054
26FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.58176868
27TP63_22573176_ChIP-Seq_HFKS_Human1.53521915
28ESR1_21235772_ChIP-Seq_MCF-7_Human1.52140967
29EGR1_19032775_ChIP-ChIP_M12_Human1.49276496
30GATA6_21074721_ChIP-Seq_CACO-2_Human1.47308072
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.39138855
32SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.33669105
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.32162251
34KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29339538
35CTCF_27219007_Chip-Seq_Bcells_Human1.28563959
36SOX2_20726797_ChIP-Seq_SW620_Human1.26332837
37EGR1_19374776_ChIP-ChIP_THP-1_Human1.25949162
38CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.25366418
39TP53_16413492_ChIP-PET_HCT116_Human1.19231610
40PPAR_26484153_Chip-Seq_NCI-H1993_Human1.18370971
41FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.17724149
42CJUN_26792858_Chip-Seq_BT549_Human1.17235504
43TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16523172
44ERG_20517297_ChIP-Seq_VCAP_Human1.16102146
45TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15365638
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14386861
47P53_21459846_ChIP-Seq_SAOS-2_Human1.13722995
48TCF4_18268006_ChIP-ChIP_LS174T_Human1.12613236
49ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09790587
50RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.09062075
51GATA3_24758297_ChIP-Seq_MCF-7_Human1.08943067
52KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07627210
53HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07269735
54ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05575882
55CTCF_20526341_ChIP-Seq_ESCs_Human1.05167574
56CLOCK_20551151_ChIP-Seq_293T_Human1.03332337
57UBF1/2_26484160_Chip-Seq_HMECs_Human1.01137919
58PPARA_22158963_ChIP-Seq_LIVER_Mouse0.98844178
59CEBPB_22108803_ChIP-Seq_LS180_Human0.97750152
60SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95628587
61NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.94535512
62NRF2_20460467_ChIP-Seq_MEFs_Mouse0.94535512
63CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.93864336
64MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.93774091
65GATA4_25053715_ChIP-Seq_YYC3_Human0.92985154
66P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.91863953
67ZNF217_24962896_ChIP-Seq_MCF-7_Human0.89870997
68SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.89212218
69KLF5_25053715_ChIP-Seq_YYC3_Human0.87913316
70YY1_22570637_ChIP-Seq_MALME-3M_Human0.85221308
71RACK7_27058665_Chip-Seq_MCF-7_Human0.81624552
72RUNX1_27514584_Chip-Seq_MCF-7_Human0.81476687
73CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.80951159
74Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.79765880
75NFIB_24661679_ChIP-Seq_LUNG_Mouse0.79594470
76PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.78776609
77GATA3_26560356_Chip-Seq_TH2_Human0.77330318
78FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.73553684
79STAT6_21828071_ChIP-Seq_BEAS2B_Human0.73431713
80TCF3_18692474_ChIP-Seq_MESCs_Mouse0.72891464
81RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.70295776
82PADI4_21655091_ChIP-ChIP_MCF-7_Human0.69748268
83FOXH1_21741376_ChIP-Seq_ESCs_Human0.69602699
84THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.68362809
85SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.68184319
86GATA3_21867929_ChIP-Seq_TH1_Mouse0.67701246
87ELF5_23300383_ChIP-Seq_T47D_Human0.67133520
88EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.66443381
89NOTCH1_21737748_ChIP-Seq_TLL_Human0.66165510
90ELK1_22589737_ChIP-Seq_MCF10A_Human0.66094179
91AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.65629612
92CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.63454529
93POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.63096454
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.63096454
95RBPJ_21746931_ChIP-Seq_IB4_Human0.61434895
96PCGF2_27294783_Chip-Seq_NPCs_Mouse0.60456828
97E2F1_20622854_ChIP-Seq_HELA_Human0.58845707
98BRD4_25478319_ChIP-Seq_HGPS_Human0.58496411
99GATA6_25053715_ChIP-Seq_YYC3_Human0.58241328
100NCOR_22424771_ChIP-Seq_293T_Human0.57985110

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier9.38748606
2MP0010234_abnormal_vibrissa_follicle8.61507525
3MP0000579_abnormal_nail_morphology5.42742948
4MP0003941_abnormal_skin_development5.36940260
5MP0005275_abnormal_skin_tensile5.35492240
6MP0005501_abnormal_skin_physiology5.19080736
7MP0003191_abnormal_cellular_cholesterol3.73746738
8MP0010678_abnormal_skin_adnexa3.58003051
9MP0003950_abnormal_plasma_membrane3.44113415
10MP0004381_abnormal_hair_follicle3.00408680
11MP0003453_abnormal_keratinocyte_physiol2.82775384
12MP0010771_integument_phenotype2.75714392
13MP0001216_abnormal_epidermal_layer2.63513509
14MP0002098_abnormal_vibrissa_morphology2.60219557
15MP0004947_skin_inflammation2.45168759
16MP0004782_abnormal_surfactant_physiolog2.37534697
17MP0000383_abnormal_hair_follicle2.27864354
18MP0002060_abnormal_skin_morphology2.25899144
19MP0000377_abnormal_hair_follicle2.04104746
20MP0003011_delayed_dark_adaptation1.95408262
21MP0000467_abnormal_esophagus_morphology1.68188525
22MP0000762_abnormal_tongue_morphology1.52251316
23MP0009931_abnormal_skin_appearance1.37326048
24MP0003656_abnormal_erythrocyte_physiolo1.36202144
25MP0000367_abnormal_coat/_hair1.31296029
26MP0004272_abnormal_basement_membrane1.26932148
27MP0003221_abnormal_cardiomyocyte_apopto1.13838272
28MP0000427_abnormal_hair_cycle1.03407113
29MP0003828_pulmonary_edema1.02912942
30MP0004185_abnormal_adipocyte_glucose0.97773777
31MP0003705_abnormal_hypodermis_morpholog0.95569520
32MP0001191_abnormal_skin_condition0.94799623
33MP0001784_abnormal_fluid_regulation0.93904242
34MP0008004_abnormal_stomach_pH0.87677300
35MP0003566_abnormal_cell_adhesion0.82005089
36MP0001243_abnormal_dermal_layer0.78436313
37MP0005377_hearing/vestibular/ear_phenot0.75119418
38MP0003878_abnormal_ear_physiology0.75119418
39MP0008057_abnormal_DNA_replication0.73163493
40MP0004510_myositis0.72955991
41MP0000647_abnormal_sebaceous_gland0.72247973
42MP0001177_atelectasis0.68262830
43MP0004885_abnormal_endolymph0.65638723
44MP0004264_abnormal_extraembryonic_tissu0.63538033
45MP0001188_hyperpigmentation0.59938183
46MP0003806_abnormal_nucleotide_metabolis0.59639838
47MP0001851_eye_inflammation0.58480867
48MP0002136_abnormal_kidney_physiology0.56082544
49MP0008058_abnormal_DNA_repair0.55806973
50MP0004270_analgesia0.55615291
51MP0005409_darkened_coat_color0.54588950
52MP0009053_abnormal_anal_canal0.52404003
53MP0009840_abnormal_foam_cell0.51227890
54MP0004043_abnormal_pH_regulation0.49937952
55MP0005023_abnormal_wound_healing0.49636817
56MP0008995_early_reproductive_senescence0.48858387
57MP0010352_gastrointestinal_tract_polyps0.46939446
58MP0002295_abnormal_pulmonary_circulatio0.46321263
59MP0005375_adipose_tissue_phenotype0.42048102
60MP0002133_abnormal_respiratory_system0.41953047
61MP0005388_respiratory_system_phenotype0.41953047
62MP0000566_synostosis0.41047875
63MP0001340_abnormal_eyelid_morphology0.40311919
64MP0003755_abnormal_palate_morphology0.38402596
65MP0009672_abnormal_birth_weight0.37340144
66MP0002234_abnormal_pharynx_morphology0.37169709
67MP0000749_muscle_degeneration0.37012401
68MP0010386_abnormal_urinary_bladder0.33236630
69MP0000003_abnormal_adipose_tissue0.31252070
70MP0008789_abnormal_olfactory_epithelium0.30067132
71MP0005075_abnormal_melanosome_morpholog0.29292733
72MP0003186_abnormal_redox_activity0.29100006
73MP0000465_gastrointestinal_hemorrhage0.28704427
74MP0002697_abnormal_eye_size0.28440617
75MP0002972_abnormal_cardiac_muscle0.27920103
76MP0001542_abnormal_bone_strength0.27351701
77MP0004197_abnormal_fetal_growth/weight/0.26484085
78MP0002971_abnormal_brown_adipose0.25954220
79MP0001502_abnormal_circadian_rhythm0.25118056
80MP0004087_abnormal_muscle_fiber0.24734625
81MP0000750_abnormal_muscle_regeneration0.23623413
82MP0009333_abnormal_splenocyte_physiolog0.23621635
83MP0001756_abnormal_urination0.23226200
84MP0000013_abnormal_adipose_tissue0.21398628
85MP0005666_abnormal_adipose_tissue0.19010058
86MP0006072_abnormal_retinal_apoptosis0.17319770
87MP0002095_abnormal_skin_pigmentation0.17202562
88MP0001529_abnormal_vocalization0.14891031
89MP0008438_abnormal_cutaneous_collagen0.14343218
90MP0009765_abnormal_xenobiotic_induced0.13593075
91MP0001299_abnormal_eye_distance/0.12433639
92MP0005620_abnormal_muscle_contractility0.12058733
93MP0002177_abnormal_outer_ear0.11690954
94MP0005076_abnormal_cell_differentiation0.11638348
95MP0000432_abnormal_head_morphology0.11556424
96MP0003786_premature_aging0.10630891
97MP0008260_abnormal_autophagy0.10139320
98MP0002069_abnormal_eating/drinking_beha0.10007239
99MP0003315_abnormal_perineum_morphology0.09842822
100MP0001765_abnormal_ion_homeostasis0.09806245

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)9.95232306
2Congenital ichthyosiform erythroderma (HP:0007431)9.25713308
3Palmoplantar hyperkeratosis (HP:0000972)8.02728350
4Palmar hyperkeratosis (HP:0010765)7.62622734
5Oral leukoplakia (HP:0002745)7.59278790
6Erythroderma (HP:0001019)7.03292782
7Plantar hyperkeratosis (HP:0007556)6.47092521
8Erythema (HP:0010783)6.37028473
9Thick nail (HP:0001805)6.10575714
10Follicular hyperkeratosis (HP:0007502)5.50860525
11Palmoplantar keratoderma (HP:0000982)4.71436977
12Ectropion (HP:0000656)4.70094779
13Corneal erosion (HP:0200020)4.67208300
14Onycholysis (HP:0001806)4.52166222
15Hypohidrosis (HP:0000966)4.29051057
16Gangrene (HP:0100758)4.07105537
17Hypotrichosis (HP:0001006)4.06352014
18Pustule (HP:0200039)3.99289635
19Fragile nails (HP:0001808)3.95606108
20Nail dystrophy (HP:0008404)3.63615410
21Hyperhidrosis (HP:0000975)3.50745233
22Lip pit (HP:0100267)3.45737231
23Corneal dystrophy (HP:0001131)3.39042308
24Pruritus (HP:0000989)3.35683594
25Popliteal pterygium (HP:0009756)3.26281125
26Sparse scalp hair (HP:0002209)3.21986651
27Laryngomalacia (HP:0001601)3.18803670
28Abnormality of small intestinal villus morphology (HP:0011472)2.88827089
29Villous atrophy (HP:0011473)2.88827089
30Natal tooth (HP:0000695)2.86451237
31Lack of skin elasticity (HP:0100679)2.84175730
32Dehydration (HP:0001944)2.78483437
33Distal lower limb muscle weakness (HP:0009053)2.72754133
34Malignant hyperthermia (HP:0002047)2.68692506
35Alopecia of scalp (HP:0002293)2.65536042
36Abnormal blistering of the skin (HP:0008066)2.63891803
37Hypergammaglobulinemia (HP:0010702)2.62642955
38Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.60360963
39Amniotic constriction ring (HP:0009775)2.58359481
40Abnormality of placental membranes (HP:0011409)2.58359481
41Brittle hair (HP:0002299)2.56548066
42Right ventricular cardiomyopathy (HP:0011663)2.45938460
43Furrowed tongue (HP:0000221)2.44657793
44Abnormality of secondary sexual hair (HP:0009888)2.19825027
45Abnormality of the axillary hair (HP:0100134)2.19825027
46Hyporeflexia of lower limbs (HP:0002600)2.12647460
47Anonychia (HP:0001798)2.05727835
48Acanthosis nigricans (HP:0000956)2.01126013
49Abnormality of nail color (HP:0100643)15.3150823
50Congenital nonbullous ichthyosiform erythroderma (HP:0007479)10.1892442
51Parakeratosis (HP:0001036)10.1291167
52Abnormality of the salivary glands (HP:0010286)1.98183738
53Advanced eruption of teeth (HP:0006288)1.94120758
54Woolly hair (HP:0002224)1.92582941
55Dry skin (HP:0000958)1.90465107
56Abnormality of the neuromuscular junction (HP:0003398)1.89973293
57Fatigable weakness (HP:0003473)1.89973293
58Eczematoid dermatitis (HP:0000976)1.89612278
59Verrucae (HP:0200043)1.89044501
60Papilloma (HP:0012740)1.89044501
61Sepsis (HP:0100806)1.87867392
62Premature ovarian failure (HP:0008209)1.86982790
63Urticaria (HP:0001025)1.84764858
64Dry hair (HP:0011359)1.80831108
65Carious teeth (HP:0000670)1.78696532
66Sparse eyelashes (HP:0000653)1.74378714
67Pterygium (HP:0001059)1.60718233
68Skin ulcer (HP:0200042)1.59780637
69Milia (HP:0001056)1.56696120
70Type 2 muscle fiber atrophy (HP:0003554)1.56425862
71Asthma (HP:0002099)1.54155808
72Epidermoid cyst (HP:0200040)1.52286528
73Muscle fiber atrophy (HP:0100295)1.49146698
74Abnormality of the fingernails (HP:0001231)1.44740292
75Areflexia of lower limbs (HP:0002522)1.44163389
76Blepharitis (HP:0000498)1.43228418
77Everted lower lip vermilion (HP:0000232)1.42761823
78Absent eyelashes (HP:0000561)1.42671073
79Emphysema (HP:0002097)1.41626197
80EMG: neuropathic changes (HP:0003445)1.36996621
81Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.35519462
82Absent hair (HP:0002298)1.32814212
83Conjunctival hamartoma (HP:0100780)1.28014757
84Tetraparesis (HP:0002273)1.21322068
85Curly hair (HP:0002212)1.16882713
86Malnutrition (HP:0004395)1.15138751
87Fine hair (HP:0002213)1.14768659
88Acanthocytosis (HP:0001927)1.12325406
89Depressed nasal tip (HP:0000437)1.10850249
90Abnormality of the labia majora (HP:0012881)1.10445000
91Distal lower limb amyotrophy (HP:0008944)1.03515374
92Multifactorial inheritance (HP:0001426)1.03151304
93Hypoplastic labia majora (HP:0000059)1.01157364
94Autoamputation (HP:0001218)0.98938493
95Paralysis (HP:0003470)0.98643337
96Type I diabetes mellitus (HP:0100651)0.95579409
97Gowers sign (HP:0003391)0.95315212
98Weak cry (HP:0001612)0.93215905
99Hoarse voice (HP:0001609)0.92948983
100Ridged nail (HP:0001807)0.91654216

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK243.52813234
2DYRK32.61430655
3ABL22.41405583
4MAP3K92.41293838
5MAP3K122.14154369
6EPHA213.0248720
7STK38L1.99871962
8MUSK1.94375419
9PIM21.83121010
10MAPK151.83014032
11IRAK21.81271662
12IRAK41.80186297
13TGFBR21.71163292
14MOS1.62406996
15IRAK11.56277299
16AKT31.50686354
17IRAK31.47037423
18IKBKE1.42264825
19TSSK61.39487351
20WNK11.27162902
21NEK11.22997429
22GRK71.18497652
23PKN11.14705592
24PDGFRB1.08309515
25ADRBK11.03957369
26MAP3K51.02380796
27TBK10.95398066
28MAP2K10.92369567
29PDK20.90753333
30LATS10.90469443
31SGK2230.89870778
32SGK4940.89870778
33MAP3K30.86128605
34LATS20.86100871
35STK30.82708770
36TAOK20.80297741
37CCNB10.77470672
38FGFR10.73527062
39CDK60.72304493
40SGK20.71843797
41STK100.69000540
42TAOK10.67374214
43BMX0.65367295
44IKBKB0.62859479
45FER0.62216052
46MTOR0.60926406
47DAPK30.60224795
48MST1R0.58545334
49SGK30.57945031
50MAPK40.56912079
51EIF2AK30.54358343
52PAK20.52538607
53NEK60.50182530
54MAP3K10.47168916
55PTK20.46834927
56BRAF0.46102939
57PIK3CG0.46046768
58GRK50.43960132
59MET0.43684523
60CHUK0.41202423
61ERBB30.37153309
62MAP3K20.36267075
63ABL10.36251782
64MST40.34664982
65MAP3K110.33921133
66GSK3A0.33519953
67TAF10.31152145
68HCK0.30800435
69MAP3K60.29667626
70MYLK0.28035133
71GRK10.26837293
72MAP3K140.26543817
73ILK0.26330600
74MARK20.24385609
75DYRK1B0.24104453
76DYRK1A0.24057899
77PRKCI0.24050647
78TGFBR10.23939911
79PRPF4B0.23754941
80EIF2AK20.22944426
81PRKCE0.22292322
82RPS6KA10.22210164
83CAMK10.19487232
84PIM10.18011733
85EPHB20.14718277
86STK380.14555699
87OBSCN0.13619315
88INSR0.12900119
89RPS6KC10.12135863
90RPS6KL10.12135863
91MAPK80.09566108
92RPS6KA60.09174717
93MAPK70.08561791
94VRK10.07939616
95ROCK10.07144421
96PAK40.06796438
97CAMK2G0.06655160
98TAOK30.06132754
99CAMK2B0.05882671
100MAPK100.05621345

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005926.98073323
2Linoleic acid metabolism_Homo sapiens_hsa005915.53291007
3NOD-like receptor signaling pathway_Homo sapiens_hsa046214.08190421
4Ether lipid metabolism_Homo sapiens_hsa005654.03354975
5Sphingolipid metabolism_Homo sapiens_hsa006003.22319833
6Arachidonic acid metabolism_Homo sapiens_hsa005902.77299012
7Fatty acid elongation_Homo sapiens_hsa000622.38794063
8Circadian rhythm_Homo sapiens_hsa047102.29139047
9p53 signaling pathway_Homo sapiens_hsa041152.26107707
10RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.05308736
11Ovarian steroidogenesis_Homo sapiens_hsa049131.72486498
12Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.69128632
13Tight junction_Homo sapiens_hsa045301.68941115
14Long-term depression_Homo sapiens_hsa047301.54971020
15GnRH signaling pathway_Homo sapiens_hsa049121.43858800
16Glycerophospholipid metabolism_Homo sapiens_hsa005641.39174474
17Fat digestion and absorption_Homo sapiens_hsa049751.36468936
18VEGF signaling pathway_Homo sapiens_hsa043701.35735739
19Vascular smooth muscle contraction_Homo sapiens_hsa042701.33663920
20Collecting duct acid secretion_Homo sapiens_hsa049661.28973577
21Endocytosis_Homo sapiens_hsa041441.13828415
22Vibrio cholerae infection_Homo sapiens_hsa051101.13267759
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.11490246
24ABC transporters_Homo sapiens_hsa020101.10773679
25FoxO signaling pathway_Homo sapiens_hsa040681.04918244
26Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.04524887
27Inositol phosphate metabolism_Homo sapiens_hsa005621.02624083
28Retinol metabolism_Homo sapiens_hsa008300.98384440
29MAPK signaling pathway_Homo sapiens_hsa040100.97302074
30Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.89424582
31ErbB signaling pathway_Homo sapiens_hsa040120.88367705
32Jak-STAT signaling pathway_Homo sapiens_hsa046300.84365428
33Basal transcription factors_Homo sapiens_hsa030220.82391718
34Ras signaling pathway_Homo sapiens_hsa040140.81201371
35Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81164654
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.81119925
37Dorso-ventral axis formation_Homo sapiens_hsa043200.79754517
38Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77766091
39Serotonergic synapse_Homo sapiens_hsa047260.77662420
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76835082
41Pancreatic secretion_Homo sapiens_hsa049720.74470597
42RNA transport_Homo sapiens_hsa030130.71489267
43Choline metabolism in cancer_Homo sapiens_hsa052310.67784130
44Amoebiasis_Homo sapiens_hsa051460.64653585
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63660340
46Glutamatergic synapse_Homo sapiens_hsa047240.61269481
47Sphingolipid signaling pathway_Homo sapiens_hsa040710.57707124
48Synaptic vesicle cycle_Homo sapiens_hsa047210.57015939
49Renin-angiotensin system_Homo sapiens_hsa046140.56599926
50Bladder cancer_Homo sapiens_hsa052190.56152869
51Hepatitis C_Homo sapiens_hsa051600.54054589
52Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53079834
53TGF-beta signaling pathway_Homo sapiens_hsa043500.53063971
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.52739622
55Oxytocin signaling pathway_Homo sapiens_hsa049210.52492175
56Renin secretion_Homo sapiens_hsa049240.52459887
57NF-kappa B signaling pathway_Homo sapiens_hsa040640.51496679
58Hippo signaling pathway_Homo sapiens_hsa043900.51013471
59Adherens junction_Homo sapiens_hsa045200.50869440
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49903828
61Renal cell carcinoma_Homo sapiens_hsa052110.49868645
62Sulfur metabolism_Homo sapiens_hsa009200.49058491
63Prion diseases_Homo sapiens_hsa050200.47729037
64Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47619856
65Mineral absorption_Homo sapiens_hsa049780.47381581
66Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47095421
67Toxoplasmosis_Homo sapiens_hsa051450.46392926
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.43451135
69Legionellosis_Homo sapiens_hsa051340.42358150
70Amphetamine addiction_Homo sapiens_hsa050310.41541983
71Platelet activation_Homo sapiens_hsa046110.39120921
72Leukocyte transendothelial migration_Homo sapiens_hsa046700.36813138
73Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36208371
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.34927131
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34818415
76Influenza A_Homo sapiens_hsa051640.34126754
77Salmonella infection_Homo sapiens_hsa051320.34053759
78Apoptosis_Homo sapiens_hsa042100.33818463
79Dilated cardiomyopathy_Homo sapiens_hsa054140.30639502
80Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.29595599
81MicroRNAs in cancer_Homo sapiens_hsa052060.29506254
82Shigellosis_Homo sapiens_hsa051310.28730851
83Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.28336435
84Estrogen signaling pathway_Homo sapiens_hsa049150.25421590
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24968143
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23843934
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.23247264
88Calcium signaling pathway_Homo sapiens_hsa040200.23165076
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.22698025
90TNF signaling pathway_Homo sapiens_hsa046680.22352995
91Glycerolipid metabolism_Homo sapiens_hsa005610.21849541
92AMPK signaling pathway_Homo sapiens_hsa041520.21262763
93Staphylococcus aureus infection_Homo sapiens_hsa051500.21138665
94HIF-1 signaling pathway_Homo sapiens_hsa040660.20599974
95Caffeine metabolism_Homo sapiens_hsa002320.18409478
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.17398312
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17313148
98Acute myeloid leukemia_Homo sapiens_hsa052210.16957105
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.16349428
100Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.16176817

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