DEFB108B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. A pseudogene of this gene has been found on chromosome 8. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1striatum development (GO:0021756)5.68985537
2cysteine metabolic process (GO:0006534)5.15832453
3nucleoside transmembrane transport (GO:1901642)5.09669339
4gamma-aminobutyric acid transport (GO:0015812)5.03740598
5negative regulation of synaptic transmission, GABAergic (GO:0032229)4.98209265
6protein K11-linked deubiquitination (GO:0035871)4.90675538
7platelet dense granule organization (GO:0060155)4.79079441
8neuronal action potential (GO:0019228)4.50909687
9positive regulation of action potential (GO:0045760)4.49343386
10detection of light stimulus involved in visual perception (GO:0050908)4.45426961
11detection of light stimulus involved in sensory perception (GO:0050962)4.45426961
12auditory behavior (GO:0031223)4.44005665
13embryonic digestive tract development (GO:0048566)4.39283151
14neuronal action potential propagation (GO:0019227)4.37250194
15behavioral response to ethanol (GO:0048149)4.35289971
16thrombin receptor signaling pathway (GO:0070493)4.20247797
17cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.94161104
18reflex (GO:0060004)3.92744001
19behavioral response to nicotine (GO:0035095)3.73697333
20serotonin metabolic process (GO:0042428)3.70992138
21neural tube formation (GO:0001841)3.55284515
22primary amino compound metabolic process (GO:1901160)3.51692510
23tryptophan catabolic process (GO:0006569)3.50503777
24indole-containing compound catabolic process (GO:0042436)3.50503777
25indolalkylamine catabolic process (GO:0046218)3.50503777
26glycerophospholipid catabolic process (GO:0046475)3.48546126
27epithelial cilium movement (GO:0003351)3.48223303
28negative regulation of telomere maintenance (GO:0032205)3.46801412
29negative regulation of actin filament bundle assembly (GO:0032232)3.40868931
30synaptic transmission, glutamatergic (GO:0035249)3.38415057
31pyrimidine dimer repair (GO:0006290)3.38195039
32RNA destabilization (GO:0050779)3.31225235
33negative regulation of Rho protein signal transduction (GO:0035024)3.29516753
34mechanosensory behavior (GO:0007638)3.28652225
35startle response (GO:0001964)3.28360959
36C4-dicarboxylate transport (GO:0015740)3.27977436
37phosphatidylinositol acyl-chain remodeling (GO:0036149)3.26017864
38epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.22581635
39pyrimidine nucleobase catabolic process (GO:0006208)3.21124963
40nucleoside transport (GO:0015858)3.19374977
41axon ensheathment in central nervous system (GO:0032291)3.17880656
42central nervous system myelination (GO:0022010)3.17880656
43cilium or flagellum-dependent cell motility (GO:0001539)3.12993367
44neurotransmitter uptake (GO:0001504)3.10953109
45outflow tract septum morphogenesis (GO:0003148)3.09419536
46retinal cone cell development (GO:0046549)3.08309372
47postsynaptic membrane organization (GO:0001941)3.07456255
48calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.07075601
49indole-containing compound metabolic process (GO:0042430)3.05487623
50photoreceptor cell maintenance (GO:0045494)3.04643062
51serotonin receptor signaling pathway (GO:0007210)3.04514422
52regulation of action potential (GO:0098900)3.00219621
53lymphangiogenesis (GO:0001946)2.96525508
54kynurenine metabolic process (GO:0070189)2.95623606
55negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.94086527
56response to auditory stimulus (GO:0010996)2.91501278
57cilium movement (GO:0003341)2.84634024
58protein localization to cilium (GO:0061512)2.79879170
59regulation of hippo signaling (GO:0035330)2.79693766
60neuron cell-cell adhesion (GO:0007158)2.79497040
61negative regulation of stress fiber assembly (GO:0051497)2.79284127
62righting reflex (GO:0060013)2.78669497
63regulation of establishment of cell polarity (GO:2000114)2.76915184
64amino-acid betaine metabolic process (GO:0006577)2.76598897
65protein K63-linked deubiquitination (GO:0070536)2.75597087
66interkinetic nuclear migration (GO:0022027)2.74375236
67neuron-neuron synaptic transmission (GO:0007270)2.74200388
68action potential (GO:0001508)2.74193431
69negative regulation of heart rate (GO:0010459)2.72626400
70mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.70465174
71positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.70465174
72axoneme assembly (GO:0035082)2.69885634
73response to nitrosative stress (GO:0051409)2.69759135
74NAD biosynthetic process (GO:0009435)2.69728817
75cell morphogenesis involved in neuron differentiation (GO:0048667)2.69668423
76positive regulation of oligodendrocyte differentiation (GO:0048714)2.68149039
77protein K48-linked deubiquitination (GO:0071108)2.65833051
78regulation of synaptic vesicle transport (GO:1902803)2.64357886
79phosphatidylserine acyl-chain remodeling (GO:0036150)2.61028499
80tryptophan metabolic process (GO:0006568)2.60920690
81homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.60185290
82cGMP-mediated signaling (GO:0019934)2.59769792
83cellular response to ATP (GO:0071318)2.59232266
84ovulation cycle (GO:0042698)2.58786704
85nonmotile primary cilium assembly (GO:0035058)2.58392491
86protein polyglutamylation (GO:0018095)2.57753511
87response to gravity (GO:0009629)2.57566415
88aspartate family amino acid catabolic process (GO:0009068)2.57194019
89establishment of protein localization to Golgi (GO:0072600)2.56936752
90Sertoli cell development (GO:0060009)2.56720945
91ubiquinone biosynthetic process (GO:0006744)2.55691609
92positive regulation of prostaglandin secretion (GO:0032308)2.55550878
93glycine transport (GO:0015816)2.55035509
94nucleobase catabolic process (GO:0046113)2.54854074
95indolalkylamine metabolic process (GO:0006586)2.54815063
96G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.54343887
97regulation of gene silencing by RNA (GO:0060966)2.52204498
98regulation of posttranscriptional gene silencing (GO:0060147)2.52204498
99regulation of gene silencing by miRNA (GO:0060964)2.52204498
100negative regulation of chondrocyte differentiation (GO:0032331)2.51068750

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse4.69230326
2GBX2_23144817_ChIP-Seq_PC3_Human4.37696029
3VDR_22108803_ChIP-Seq_LS180_Human3.94309541
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.42909206
5ZNF274_21170338_ChIP-Seq_K562_Hela3.39488052
6EZH2_22144423_ChIP-Seq_EOC_Human3.36106119
7IGF1R_20145208_ChIP-Seq_DFB_Human2.90522185
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.63392575
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.48677736
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.43151695
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.38083203
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.31719218
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.28581487
14TAF15_26573619_Chip-Seq_HEK293_Human2.27739502
15AR_21572438_ChIP-Seq_LNCaP_Human2.15027017
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.13698553
17SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.08503227
18EWS_26573619_Chip-Seq_HEK293_Human2.01858708
19ER_23166858_ChIP-Seq_MCF-7_Human1.97485324
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.95750847
21P300_19829295_ChIP-Seq_ESCs_Human1.89450947
22STAT3_23295773_ChIP-Seq_U87_Human1.85966371
23AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.79541136
24AR_25329375_ChIP-Seq_VCAP_Human1.76805021
25PIAS1_25552417_ChIP-Seq_VCAP_Human1.75007329
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.72997317
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68601256
28FUS_26573619_Chip-Seq_HEK293_Human1.66183100
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.62472224
30REST_21632747_ChIP-Seq_MESCs_Mouse1.59784376
31NR3C1_21868756_ChIP-Seq_MCF10A_Human1.59205105
32SMAD4_21799915_ChIP-Seq_A2780_Human1.58636371
33* TCF4_23295773_ChIP-Seq_U87_Human1.58078514
34DROSHA_22980978_ChIP-Seq_HELA_Human1.52455148
35OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46795548
36SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45835788
37TP53_16413492_ChIP-PET_HCT116_Human1.45808008
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.43877652
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43789924
40BCAT_22108803_ChIP-Seq_LS180_Human1.41197604
41RNF2_27304074_Chip-Seq_NSC_Mouse1.38421016
42TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37843993
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35548269
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.34368850
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.33529467
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33525763
47MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25862889
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22155542
49TCF4_22108803_ChIP-Seq_LS180_Human1.20596464
50SMAD4_21741376_ChIP-Seq_EPCs_Human1.19953634
51IRF1_19129219_ChIP-ChIP_H3396_Human1.19871119
52TP53_22573176_ChIP-Seq_HFKS_Human1.19635641
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19102380
54CBP_20019798_ChIP-Seq_JUKART_Human1.19102380
55KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.18908584
56EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16584650
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.16433739
58RUNX2_22187159_ChIP-Seq_PCA_Human1.16307906
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15190997
60PRDM14_20953172_ChIP-Seq_ESCs_Human1.14251355
61FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14160885
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.14160885
63BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13637107
64SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.11895757
65FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11346324
66IRF8_22096565_ChIP-ChIP_GC-B_Human1.11055865
67FLI1_21867929_ChIP-Seq_TH2_Mouse1.10877414
68CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10607138
69GATA3_21878914_ChIP-Seq_MCF-7_Human1.10567923
70JUN_21703547_ChIP-Seq_K562_Human1.10127725
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08727631
72RBPJ_22232070_ChIP-Seq_NCS_Mouse1.07498527
73SOX2_21211035_ChIP-Seq_LN229_Gbm1.06694544
74REST_18959480_ChIP-ChIP_MESCs_Mouse1.05950727
75MYC_18940864_ChIP-ChIP_HL60_Human1.05634983
76NANOG_18555785_Chip-Seq_ESCs_Mouse1.05224964
77BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04433078
78NANOG_19829295_ChIP-Seq_ESCs_Human1.04423679
79SOX2_19829295_ChIP-Seq_ESCs_Human1.04423679
80TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04026755
81JARID2_20064375_ChIP-Seq_MESCs_Mouse1.03147358
82NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03113134
83NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03113134
84HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.03046308
85SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01319178
86EZH2_27304074_Chip-Seq_ESCs_Mouse0.99636909
87CRX_20693478_ChIP-Seq_RETINA_Mouse0.99101423
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98092997
89TAL1_26923725_Chip-Seq_HPCs_Mouse0.97616176
90NOTCH1_21737748_ChIP-Seq_TLL_Human0.97061446
91NFE2_27457419_Chip-Seq_LIVER_Mouse0.96320046
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96235984
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95347327
94PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93491748
95P53_22387025_ChIP-Seq_ESCs_Mouse0.92970537
96HOXB7_26014856_ChIP-Seq_BT474_Human0.92133143
97AR_20517297_ChIP-Seq_VCAP_Human0.90767207
98P53_22127205_ChIP-Seq_FIBROBLAST_Human0.90716414
99NCOR_22424771_ChIP-Seq_293T_Human0.88924896
100SMAD3_21741376_ChIP-Seq_ESCs_Human0.88454884

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.78541967
2MP0010030_abnormal_orbit_morphology4.69401504
3MP0005248_abnormal_Harderian_gland3.98849289
4MP0002736_abnormal_nociception_after3.65580533
5MP0001984_abnormal_olfaction2.62513503
6MP0001968_abnormal_touch/_nociception2.61460666
7MP0002138_abnormal_hepatobiliary_system2.57697612
8MP0003136_yellow_coat_color2.30042524
9MP0005670_abnormal_white_adipose2.29090644
10MP0004142_abnormal_muscle_tone2.27135236
11MP0005551_abnormal_eye_electrophysiolog2.25438853
12MP0008875_abnormal_xenobiotic_pharmacok2.24243544
13MP0000613_abnormal_salivary_gland2.22841467
14MP0009046_muscle_twitch2.21213366
15MP0004885_abnormal_endolymph2.08481529
16MP0010386_abnormal_urinary_bladder2.06975916
17MP0004043_abnormal_pH_regulation2.02083760
18MP0009745_abnormal_behavioral_response1.92462988
19MP0005595_abnormal_vascular_smooth1.91165943
20MP0001486_abnormal_startle_reflex1.90847225
21MP0008877_abnormal_DNA_methylation1.80555137
22MP0003718_maternal_effect1.78643900
23MP0002272_abnormal_nervous_system1.72236210
24MP0005171_absent_coat_pigmentation1.68898780
25MP0002876_abnormal_thyroid_physiology1.66944223
26MP0001970_abnormal_pain_threshold1.66079122
27MP0003635_abnormal_synaptic_transmissio1.65497256
28MP0001919_abnormal_reproductive_system1.64021399
29MP0006276_abnormal_autonomic_nervous1.55655983
30MP0002064_seizures1.53912349
31MP0005253_abnormal_eye_physiology1.50149945
32MP0002733_abnormal_thermal_nociception1.49982215
33MP0002063_abnormal_learning/memory/cond1.45407718
34MP0005083_abnormal_biliary_tract1.43504424
35MP0002249_abnormal_larynx_morphology1.42565223
36MP0002282_abnormal_trachea_morphology1.42124867
37MP0002572_abnormal_emotion/affect_behav1.39190010
38MP0003011_delayed_dark_adaptation1.37759331
39MP0000383_abnormal_hair_follicle1.37510772
40MP0004147_increased_porphyrin_level1.37223603
41MP0002735_abnormal_chemical_nociception1.36286158
42MP0000013_abnormal_adipose_tissue1.35322336
43MP0001529_abnormal_vocalization1.34857855
44MP0005423_abnormal_somatic_nervous1.34521876
45MP0000230_abnormal_systemic_arterial1.34463586
46MP0001501_abnormal_sleep_pattern1.32422237
47MP0002734_abnormal_mechanical_nocicepti1.20647751
48MP0005389_reproductive_system_phenotype1.20031423
49MP0002067_abnormal_sensory_capabilities1.19963375
50MP0002234_abnormal_pharynx_morphology1.19693257
51MP0003195_calcinosis1.14583945
52MP0003646_muscle_fatigue1.10454981
53MP0002909_abnormal_adrenal_gland1.09152293
54MP0001986_abnormal_taste_sensitivity1.08323518
55MP0005365_abnormal_bile_salt1.08211939
56MP0003724_increased_susceptibility_to1.04005017
57MP0000631_abnormal_neuroendocrine_gland1.03976791
58MP0005646_abnormal_pituitary_gland1.03947117
59MP0002102_abnormal_ear_morphology1.03642679
60MP0002638_abnormal_pupillary_reflex1.02773725
61MP0002332_abnormal_exercise_endurance1.02294825
62MP0002653_abnormal_ependyma_morphology1.01037466
63MP0001664_abnormal_digestion1.00959366
64MP0005310_abnormal_salivary_gland0.98165157
65MP0005084_abnormal_gallbladder_morpholo0.98004371
66MP0006054_spinal_hemorrhage0.96595504
67MP0002557_abnormal_social/conspecific_i0.96562963
68MP0004742_abnormal_vestibular_system0.87530852
69MP0002932_abnormal_joint_morphology0.87200105
70MP0000778_abnormal_nervous_system0.86599901
71MP0005197_abnormal_uvea_morphology0.86355814
72MP0005195_abnormal_posterior_eye0.83717820
73MP0005645_abnormal_hypothalamus_physiol0.83614839
74MP0003283_abnormal_digestive_organ0.82644382
75MP0005410_abnormal_fertilization0.81920258
76MP0004130_abnormal_muscle_cell0.79108621
77MP0004859_abnormal_synaptic_plasticity0.78441386
78MP0000026_abnormal_inner_ear0.77434060
79MP0003633_abnormal_nervous_system0.76737412
80MP0008569_lethality_at_weaning0.76031229
81MP0005174_abnormal_tail_pigmentation0.75870988
82MP0005508_abnormal_skeleton_morphology0.74014485
83MP0003632_abnormal_nervous_system0.72661681
84MP0001963_abnormal_hearing_physiology0.72654125
85MP0002882_abnormal_neuron_morphology0.72627558
86MP0000955_abnormal_spinal_cord0.72158888
87MP0002752_abnormal_somatic_nervous0.71572802
88MP0003698_abnormal_male_reproductive0.71493564
89MP0005386_behavior/neurological_phenoty0.71021157
90MP0004924_abnormal_behavior0.71021157
91MP0002229_neurodegeneration0.70473527
92MP0008058_abnormal_DNA_repair0.67895707
93MP0003656_abnormal_erythrocyte_physiolo0.67528792
94MP0001324_abnormal_eye_pigmentation0.66882349
95MP0000647_abnormal_sebaceous_gland0.66314524
96MP0004084_abnormal_cardiac_muscle0.65272814
97MP0004085_abnormal_heartbeat0.63757578
98MP0005360_urolithiasis0.63030337
99MP0001270_distended_abdomen0.62655885
100MP0003787_abnormal_imprinting0.62362002

Predicted human phenotypes

RankGene SetZ-score
1Abnormal pancreas size (HP:0012094)6.38307618
2Annular pancreas (HP:0001734)5.46170568
3Pancreatic cysts (HP:0001737)4.68149121
4Tubular atrophy (HP:0000092)4.56035893
5Chronic hepatic failure (HP:0100626)4.19137712
6Pancreatic fibrosis (HP:0100732)4.03272588
7Bicornuate uterus (HP:0000813)3.84360146
8Congenital sensorineural hearing impairment (HP:0008527)3.65834861
9Absent speech (HP:0001344)3.50374224
10Anophthalmia (HP:0000528)3.47493868
11Hemiparesis (HP:0001269)3.46302636
12Abnormality of the renal cortex (HP:0011035)3.36603144
13Hyperventilation (HP:0002883)3.34859959
14True hermaphroditism (HP:0010459)3.34762885
15Genetic anticipation (HP:0003743)3.32960538
16Bile duct proliferation (HP:0001408)3.29371997
17Abnormal biliary tract physiology (HP:0012439)3.29371997
18Nephronophthisis (HP:0000090)3.25966638
19Type II lissencephaly (HP:0007260)3.25148676
20Molar tooth sign on MRI (HP:0002419)3.24976676
21Abnormality of midbrain morphology (HP:0002418)3.24976676
22Attenuation of retinal blood vessels (HP:0007843)3.14678498
23Abolished electroretinogram (ERG) (HP:0000550)3.12295360
24Tubulointerstitial fibrosis (HP:0005576)3.08926867
25Medial flaring of the eyebrow (HP:0010747)3.07949294
26Abnormality of the renal medulla (HP:0100957)3.07529722
27Congenital stationary night blindness (HP:0007642)3.04618391
28Hemiplegia (HP:0002301)3.03410084
29Lower limb hyperreflexia (HP:0002395)3.01144970
30Large for gestational age (HP:0001520)2.98687595
31Cerebellar dysplasia (HP:0007033)2.93329617
32Abnormal drinking behavior (HP:0030082)2.93259845
33Polydipsia (HP:0001959)2.93259845
34Inability to walk (HP:0002540)2.76574004
35Abnormal lung lobation (HP:0002101)2.65458929
36Progressive inability to walk (HP:0002505)2.63032882
37Gait imbalance (HP:0002141)2.61542173
38Retinal dysplasia (HP:0007973)2.54775277
39Bony spicule pigmentary retinopathy (HP:0007737)2.51907557
40Decreased circulating renin level (HP:0003351)2.51905268
41Congenital primary aphakia (HP:0007707)2.50155600
42Dynein arm defect of respiratory motile cilia (HP:0012255)2.49961200
43Absent/shortened dynein arms (HP:0200106)2.49961200
44Tubulointerstitial abnormality (HP:0001969)2.48881198
45Autoimmune thrombocytopenia (HP:0001973)2.46547258
46Cystic liver disease (HP:0006706)2.46054479
47Polyuria (HP:0000103)2.42690045
48Progressive cerebellar ataxia (HP:0002073)2.41356784
49Nephrogenic diabetes insipidus (HP:0009806)2.36946628
50Diplopia (HP:0000651)2.32845481
51Abnormality of binocular vision (HP:0011514)2.32845481
52Congenital hepatic fibrosis (HP:0002612)2.32844201
53Lissencephaly (HP:0001339)2.30250349
54Abnormal urine output (HP:0012590)2.30119868
55Bilateral sensorineural hearing impairment (HP:0008619)2.23299884
56Optic nerve hypoplasia (HP:0000609)2.17809412
57Gonadotropin excess (HP:0000837)2.17211048
58Status epilepticus (HP:0002133)2.17087798
59Hyperglycinuria (HP:0003108)2.16677048
60Febrile seizures (HP:0002373)2.15427793
61Focal motor seizures (HP:0011153)2.15333380
62Stomach cancer (HP:0012126)2.15079481
63Protruding tongue (HP:0010808)2.12181801
64Aplasia/Hypoplasia of the tibia (HP:0005772)2.08498679
65Gaze-evoked nystagmus (HP:0000640)2.05282381
66Genital tract atresia (HP:0001827)2.03992584
67Postaxial foot polydactyly (HP:0001830)2.03948673
68Absence seizures (HP:0002121)2.03670257
69Clumsiness (HP:0002312)2.02618783
70Potter facies (HP:0002009)2.00192550
71Facial shape deformation (HP:0011334)2.00192550
72Mesangial abnormality (HP:0001966)1.94784007
73Drooling (HP:0002307)1.93462873
74Generalized tonic-clonic seizures (HP:0002069)1.93013450
75Abnormality of dental color (HP:0011073)1.92898857
76Abnormality of the periventricular white matter (HP:0002518)1.91615601
77Tinnitus (HP:0000360)1.91548970
78Syncope (HP:0001279)1.91352350
79Dialeptic seizures (HP:0011146)1.90874083
80Carpal bone hypoplasia (HP:0001498)1.90197924
81Vaginal atresia (HP:0000148)1.87203768
82Amyotrophic lateral sclerosis (HP:0007354)1.86800123
83Hydroxyprolinuria (HP:0003080)1.85993866
84Abnormality of proline metabolism (HP:0010907)1.85993866
85Abnormality of renal excretion (HP:0011036)1.84940914
86Intellectual disability, profound (HP:0002187)1.83772702
87Aplasia/hypoplasia of the uterus (HP:0008684)1.83453010
88Broad nasal tip (HP:0000455)1.83056979
89Spastic tetraparesis (HP:0001285)1.80520703
90Hyperaldosteronism (HP:0000859)1.79111174
91Aplasia/Hypoplasia of the tongue (HP:0010295)1.78883577
92Decreased electroretinogram (ERG) amplitude (HP:0000654)1.78634454
93Partial agenesis of the corpus callosum (HP:0001338)1.78154275
94Excessive salivation (HP:0003781)1.74550656
95Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74468916
96Poor coordination (HP:0002370)1.74460838
97Hypoplasia of the uterus (HP:0000013)1.73911718
98Occipital encephalocele (HP:0002085)1.73503374
99Polyphagia (HP:0002591)1.72884110
100Neonatal respiratory distress (HP:0002643)1.71984101

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK16.53981933
2FRK4.80884990
3WNK33.13899632
4TNIK2.65671821
5MAP3K42.55551624
6STK38L2.34575773
7BMPR1B2.20997871
8MKNK22.16735614
9MARK12.11702056
10EIF2AK32.08756252
11ADRBK22.03926909
12MAP2K71.98321852
13GRK11.96644016
14TRIM281.85275984
15CAMKK21.80030504
16CASK1.71997584
17MAPK131.62279088
18INSRR1.61517827
19ACVR1B1.53007105
20MAP4K21.48010425
21PDK21.44495448
22MKNK11.40066536
23NTRK31.39788357
24PTK2B1.38827541
25PRKG21.30652361
26ZAK1.28731437
27PBK1.25345649
28PRKCG1.24470139
29CSNK1G21.22552768
30DYRK21.19236439
31MAPKAPK31.19008301
32TXK1.12380046
33NTRK21.09570110
34BCR1.09116246
35NEK60.98224903
36IRAK10.97492273
37TAOK30.92216237
38STK380.91993046
39TYRO30.90946951
40TLK10.87311311
41CSNK1G30.87195537
42CAMKK10.85253454
43PAK30.85172039
44PRKCE0.85015210
45AKT30.83191807
46CSNK1A1L0.81380254
47MAPK150.78750293
48PRKCQ0.78367266
49CAMK2A0.77901907
50PIK3CG0.74480708
51NME10.74430902
52PIK3CA0.73336031
53MATK0.71104452
54DAPK20.71084035
55PRKCZ0.70277649
56NEK90.69567093
57SIK20.68745403
58VRK10.68009412
59CAMK2B0.66870304
60FER0.63894519
61ADRBK10.63752499
62DYRK1A0.62137093
63EPHA40.62095815
64PHKG10.60052961
65PHKG20.60052961
66CSNK1G10.58985357
67RPS6KA50.57697798
68CSNK1D0.54994126
69PAK60.54749660
70SRPK10.54358199
71PRKACA0.54185885
72YES10.53438763
73CAMK2G0.52244228
74MAP2K40.52104698
75TGFBR10.51263638
76CSNK1A10.50692692
77CAMK2D0.49802079
78IKBKE0.48607302
79PRKCH0.48491716
80CAMK10.47805653
81PLK40.44909035
82PRKCA0.44439399
83PRKACB0.44275010
84PRKACG0.43385588
85WNK40.42325587
86NUAK10.42241926
87CDK50.40613527
88PLK20.39864779
89PRKG10.39426772
90PKN10.38715477
91IRAK40.35808535
92CAMK40.35310384
93OBSCN0.35088265
94PRKCB0.34222210
95NLK0.34099446
96IGF1R0.32843430
97OXSR10.29699604
98GRK70.29594726
99MAPK10.28875168
100ABL10.28710170

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.10500980
2Linoleic acid metabolism_Homo sapiens_hsa005912.87863456
3Nicotine addiction_Homo sapiens_hsa050332.87671286
4Taste transduction_Homo sapiens_hsa047422.55722353
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.43766918
6Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.23259158
7Selenocompound metabolism_Homo sapiens_hsa004502.17760271
8Ether lipid metabolism_Homo sapiens_hsa005652.13918524
9Butanoate metabolism_Homo sapiens_hsa006502.13817546
10Nitrogen metabolism_Homo sapiens_hsa009102.05598674
11Glycerolipid metabolism_Homo sapiens_hsa005612.03690267
12Histidine metabolism_Homo sapiens_hsa003402.02658252
13Sulfur relay system_Homo sapiens_hsa041221.84982926
14Phototransduction_Homo sapiens_hsa047441.84735858
15Glutamatergic synapse_Homo sapiens_hsa047241.82070468
16Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.78737060
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.69441818
18Salivary secretion_Homo sapiens_hsa049701.66949675
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.66160518
20Tryptophan metabolism_Homo sapiens_hsa003801.60363402
21Fatty acid biosynthesis_Homo sapiens_hsa000611.58369835
22Olfactory transduction_Homo sapiens_hsa047401.57463255
23Long-term depression_Homo sapiens_hsa047301.50038323
24Calcium signaling pathway_Homo sapiens_hsa040201.49991292
25Morphine addiction_Homo sapiens_hsa050321.49795374
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47532302
27Chemical carcinogenesis_Homo sapiens_hsa052041.47302499
28Ovarian steroidogenesis_Homo sapiens_hsa049131.45931849
29Peroxisome_Homo sapiens_hsa041461.44344241
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43463092
31Serotonergic synapse_Homo sapiens_hsa047261.41071901
32Arachidonic acid metabolism_Homo sapiens_hsa005901.36839379
33Propanoate metabolism_Homo sapiens_hsa006401.36109154
34Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.35756745
35Circadian entrainment_Homo sapiens_hsa047131.34592382
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.34559683
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.33678319
38beta-Alanine metabolism_Homo sapiens_hsa004101.31782787
39GABAergic synapse_Homo sapiens_hsa047271.30062708
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.27864988
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.15998901
42ABC transporters_Homo sapiens_hsa020101.15206015
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.12375647
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.11843742
45Glutathione metabolism_Homo sapiens_hsa004801.11831382
46Retinol metabolism_Homo sapiens_hsa008301.09260785
47Glycosaminoglycan degradation_Homo sapiens_hsa005311.09041560
48Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.07788119
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.05195198
50Insulin secretion_Homo sapiens_hsa049110.98604552
51Gastric acid secretion_Homo sapiens_hsa049710.96447555
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.95525835
53Glycerophospholipid metabolism_Homo sapiens_hsa005640.94137211
54Mineral absorption_Homo sapiens_hsa049780.91795218
55RNA polymerase_Homo sapiens_hsa030200.88824579
56Basal transcription factors_Homo sapiens_hsa030220.88646767
57Fanconi anemia pathway_Homo sapiens_hsa034600.88374086
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.85828415
59Cocaine addiction_Homo sapiens_hsa050300.82733100
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80069966
61RNA degradation_Homo sapiens_hsa030180.80008649
62Steroid biosynthesis_Homo sapiens_hsa001000.78213878
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76759445
64African trypanosomiasis_Homo sapiens_hsa051430.75467467
65Thyroid hormone synthesis_Homo sapiens_hsa049180.73861435
66Oxytocin signaling pathway_Homo sapiens_hsa049210.71348043
67Choline metabolism in cancer_Homo sapiens_hsa052310.70812754
68Dopaminergic synapse_Homo sapiens_hsa047280.69453248
69One carbon pool by folate_Homo sapiens_hsa006700.67598752
70Fatty acid degradation_Homo sapiens_hsa000710.66853025
71Renin secretion_Homo sapiens_hsa049240.66213611
72Bile secretion_Homo sapiens_hsa049760.65911200
73Amphetamine addiction_Homo sapiens_hsa050310.64471548
74Fat digestion and absorption_Homo sapiens_hsa049750.63977976
75Protein export_Homo sapiens_hsa030600.62349004
76Cholinergic synapse_Homo sapiens_hsa047250.61237617
77Cyanoamino acid metabolism_Homo sapiens_hsa004600.56747947
78cAMP signaling pathway_Homo sapiens_hsa040240.55010600
79Pyruvate metabolism_Homo sapiens_hsa006200.54134992
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49109558
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47824227
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.47368485
83Pancreatic secretion_Homo sapiens_hsa049720.45708850
84Homologous recombination_Homo sapiens_hsa034400.45282769
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44933375
86Platelet activation_Homo sapiens_hsa046110.44516405
87Circadian rhythm_Homo sapiens_hsa047100.43895792
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42961375
89Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.42619790
90Metabolic pathways_Homo sapiens_hsa011000.40022543
91Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.39758421
92Lysine degradation_Homo sapiens_hsa003100.39460624
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38427934
94Regulation of autophagy_Homo sapiens_hsa041400.36725396
95Type II diabetes mellitus_Homo sapiens_hsa049300.36418584
96Arginine and proline metabolism_Homo sapiens_hsa003300.33715695
97Dorso-ventral axis formation_Homo sapiens_hsa043200.32430834
98Axon guidance_Homo sapiens_hsa043600.32360205
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31063943
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.28917639

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »