DEGS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the membrane fatty acid desaturase family which is responsible for inserting double bonds into specific positions in fatty acids. This protein contains three His-containing consensus motifs that are characteristic of a group of membrane fatty acid desaturases. It is predicted to be a multiple membrane-spanning protein localized to the endoplasmic reticulum. Overexpression of this gene inhibited biosynthesis of the EGF receptor, suggesting a possible role of a fatty acid desaturase in regulating biosynthetic processing of the EGF receptor. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)8.73891130
2axon ensheathment in central nervous system (GO:0032291)8.73891130
3fatty acid elongation (GO:0030497)6.70866515
4ensheathment of neurons (GO:0007272)5.62676597
5axon ensheathment (GO:0008366)5.62676597
6myelination (GO:0042552)5.51958529
7proteasome assembly (GO:0043248)4.89599129
8myelin maintenance (GO:0043217)4.85711139
9cholesterol biosynthetic process (GO:0006695)4.49688141
10desmosome organization (GO:0002934)4.45619512
11adhesion of symbiont to host cell (GO:0044650)4.36449231
12virion attachment to host cell (GO:0019062)4.36449231
13long-chain fatty acid biosynthetic process (GO:0042759)4.32098311
14negative regulation of neurotransmitter secretion (GO:0046929)4.28004747
15skin morphogenesis (GO:0043589)4.24971588
16keratinization (GO:0031424)4.20721211
17signal peptide processing (GO:0006465)4.15949733
18response to redox state (GO:0051775)4.13400652
19establishment of skin barrier (GO:0061436)4.10763164
20long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.02724257
21sterol biosynthetic process (GO:0016126)4.01147555
22amyloid precursor protein metabolic process (GO:0042982)3.99136474
23response to lipoprotein particle (GO:0055094)3.97972657
24regulation of water loss via skin (GO:0033561)3.93559020
25type B pancreatic cell proliferation (GO:0044342)3.92746620
26apical protein localization (GO:0045176)3.90556386
27nucleotide transmembrane transport (GO:1901679)3.77379869
28amyloid precursor protein catabolic process (GO:0042987)3.69144992
29creatine metabolic process (GO:0006600)3.65567311
30eye photoreceptor cell differentiation (GO:0001754)3.61497936
31photoreceptor cell differentiation (GO:0046530)3.61497936
32asymmetric protein localization (GO:0008105)3.58555244
33leukocyte migration involved in inflammatory response (GO:0002523)3.57549943
34oligodendrocyte differentiation (GO:0048709)3.54876870
35maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.54378366
36keratinocyte proliferation (GO:0043616)3.48533473
37fatty-acyl-CoA biosynthetic process (GO:0046949)3.48374448
38negative regulation of neurotransmitter transport (GO:0051589)3.47710465
39glycosylceramide metabolic process (GO:0006677)3.46973361
40long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.46622893
41magnesium ion transport (GO:0015693)3.43257433
42adhesion of symbiont to host (GO:0044406)3.42269733
43cell adhesion mediated by integrin (GO:0033627)3.40138650
44membrane raft organization (GO:0031579)3.39660361
45protein deneddylation (GO:0000338)3.36871468
46response to methylmercury (GO:0051597)3.35279903
47positive regulation of oligodendrocyte differentiation (GO:0048714)3.35103266
48ER overload response (GO:0006983)3.34805666
49substantia nigra development (GO:0021762)3.33898663
50hemidesmosome assembly (GO:0031581)3.32962183
51glycerophospholipid catabolic process (GO:0046475)3.32325796
52import into cell (GO:0098657)3.30761844
53regulation of lipoprotein metabolic process (GO:0050746)3.27743609
54nuclear envelope reassembly (GO:0031468)3.27585820
55mitotic nuclear envelope reassembly (GO:0007084)3.27585820
56protein retention in ER lumen (GO:0006621)3.21018310
57isoprenoid biosynthetic process (GO:0008299)3.20010979
58negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.19354299
59wound healing, spreading of epidermal cells (GO:0035313)3.15566972
60regulation of cellular amino acid metabolic process (GO:0006521)3.14493678
61positive regulation of actin filament depolymerization (GO:0030836)3.14091626
62negative regulation of protein localization to cell surface (GO:2000009)3.12738915
63regulation of collateral sprouting (GO:0048670)3.10928461
64protein maturation by protein folding (GO:0022417)3.10468024
65hair cycle (GO:0042633)3.08881842
66molting cycle (GO:0042303)3.08881842
67fatty-acyl-CoA metabolic process (GO:0035337)3.08553937
68cullin deneddylation (GO:0010388)3.08061129
69ribosome assembly (GO:0042255)3.07621893
70negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.03075371
71negative regulation of ligase activity (GO:0051352)3.03075371
72positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.02343810
73peptidyl-tyrosine autophosphorylation (GO:0038083)3.00681711
74protein heterotrimerization (GO:0070208)2.98317321
75negative regulation of nitric oxide biosynthetic process (GO:0045019)2.96509747
76antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.95408060
77regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.94969756
78astrocyte development (GO:0014002)2.94683037
79protein palmitoylation (GO:0018345)2.94607369
80erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.93340127
81L-phenylalanine catabolic process (GO:0006559)2.93340127
82basement membrane organization (GO:0071711)2.92285210
83response to testosterone (GO:0033574)2.91725370
84GPI anchor biosynthetic process (GO:0006506)2.86823436
85protein localization to endosome (GO:0036010)2.86789325
86interleukin-6-mediated signaling pathway (GO:0070102)2.86412095
87endodermal cell differentiation (GO:0035987)2.84697763
88establishment of mitochondrion localization (GO:0051654)2.84166518
89membrane protein ectodomain proteolysis (GO:0006509)2.83922547
90antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.81832544
91regulation of integrin-mediated signaling pathway (GO:2001044)2.81402637
92branching involved in prostate gland morphogenesis (GO:0060442)2.80398572
93anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.79644763
94positive regulation of glial cell differentiation (GO:0045687)2.79557125
95cellular response to hepatocyte growth factor stimulus (GO:0035729)2.79460565
96response to hepatocyte growth factor (GO:0035728)2.79460565
97negative regulation of JUN kinase activity (GO:0043508)2.77725218
98myelination in peripheral nervous system (GO:0022011)2.77471991
99peripheral nervous system axon ensheathment (GO:0032292)2.77471991
100cellular response to vitamin (GO:0071295)2.76489035
101regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.75543520
102DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.74556062
103very long-chain fatty acid metabolic process (GO:0000038)2.73577584
104copper ion homeostasis (GO:0055070)2.72878900
105acyl-CoA biosynthetic process (GO:0071616)2.72771121
106thioester biosynthetic process (GO:0035384)2.72771121
107natural killer cell mediated cytotoxicity (GO:0042267)2.71882937
108natural killer cell mediated immunity (GO:0002228)2.71882937
109collagen fibril organization (GO:0030199)2.71424780
110antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.71059268
111regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.70735784
112intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.70456469
113signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.70456469
114lipopolysaccharide biosynthetic process (GO:0009103)2.70246635
115regulation of translational termination (GO:0006449)2.68367601
116signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.66240533
117signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.66240533
118signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.66240533
119negative regulation of smooth muscle cell migration (GO:0014912)2.66164784
120nucleotide transport (GO:0006862)2.65636142
121GPI anchor metabolic process (GO:0006505)2.64898042
122regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.64213104
123neutrophil activation involved in immune response (GO:0002283)2.63732600
124peptidyl-cysteine modification (GO:0018198)2.63301588
125dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.62058530
126sprouting angiogenesis (GO:0002040)2.62024424
127Golgi transport vesicle coating (GO:0048200)2.61435850
128COPI coating of Golgi vesicle (GO:0048205)2.61435850
129nucleobase-containing small molecule interconversion (GO:0015949)2.60674056
130axon development (GO:0061564)2.60335088
131positive regulation of cellular amine metabolic process (GO:0033240)2.59778809
132detection of temperature stimulus involved in sensory perception (GO:0050961)2.59056924
133detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.59056924
134signal transduction involved in DNA damage checkpoint (GO:0072422)2.57945675
135signal transduction involved in DNA integrity checkpoint (GO:0072401)2.57945675
136prostanoid biosynthetic process (GO:0046457)2.57341854
137prostaglandin biosynthetic process (GO:0001516)2.57341854
138protein hydroxylation (GO:0018126)2.56614001
139extracellular fibril organization (GO:0043206)2.56602577
140endothelial cell morphogenesis (GO:0001886)2.55319925
141peptide cross-linking (GO:0018149)2.51430763
142keratan sulfate catabolic process (GO:0042340)2.51183970
143positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.49939117
144protein heterotetramerization (GO:0051290)2.49832361
145signal transduction involved in cell cycle checkpoint (GO:0072395)2.49599749
146keratinocyte differentiation (GO:0030216)2.49102528
147L-phenylalanine metabolic process (GO:0006558)2.47712785
148erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.47712785
149negative regulation of nitric-oxide synthase activity (GO:0051001)2.47383850
150cellular copper ion homeostasis (GO:0006878)2.45804086
151ventricular cardiac muscle cell development (GO:0055015)2.45697644
152hyaluronan catabolic process (GO:0030214)2.45524402
153response to lead ion (GO:0010288)2.44909245
154linoleic acid metabolic process (GO:0043651)2.44655170
155positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.44355100
156wound healing, spreading of cells (GO:0044319)2.43755669
157tissue regeneration (GO:0042246)2.41369709
158positive regulation of gliogenesis (GO:0014015)2.41177536
159negative regulation of acute inflammatory response (GO:0002674)2.40750388
160UDP-N-acetylglucosamine metabolic process (GO:0006047)2.40279938
161dopamine biosynthetic process (GO:0042416)2.40268253
162positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.38360026
163sequestering of metal ion (GO:0051238)2.38151401
164positive regulation of ligase activity (GO:0051351)2.38028998
165preassembly of GPI anchor in ER membrane (GO:0016254)2.37464407
166negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.37280909
167regulation of amyloid precursor protein catabolic process (GO:1902991)2.36030884
168fibril organization (GO:0097435)2.35565268
169regulation of osteoblast proliferation (GO:0033688)2.35244185
170peptidyl-proline hydroxylation (GO:0019511)2.34555173
171positive regulation of interleukin-8 secretion (GO:2000484)2.34381312
172response to dietary excess (GO:0002021)2.34338245
173positive regulation of osteoblast proliferation (GO:0033690)2.31039106
174heme transport (GO:0015886)2.31033927
175regulation of ubiquitin-protein transferase activity (GO:0051438)2.30897359
176positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.30671837
177protein neddylation (GO:0045116)2.30344023
178peripheral nervous system development (GO:0007422)2.29043038
179actin filament depolymerization (GO:0030042)2.28946607
180cellular response to vitamin D (GO:0071305)2.28598797
181lipopolysaccharide metabolic process (GO:0008653)2.28194740
182Golgi to plasma membrane protein transport (GO:0043001)2.28127296
183L-amino acid import (GO:0043092)2.27330117
184sphingosine metabolic process (GO:0006670)2.26999521
185tricarboxylic acid cycle (GO:0006099)2.26417022
186cell redox homeostasis (GO:0045454)2.21793260
187regulation of ligase activity (GO:0051340)2.21657994
188vascular endothelial growth factor signaling pathway (GO:0038084)2.20687855

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human3.71981674
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.37542658
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.98828153
4GABP_17652178_ChIP-ChIP_JURKAT_Human2.95553327
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.88683801
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.76328356
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.67170664
8SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.56035002
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.53988895
10* MYC_18555785_ChIP-Seq_MESCs_Mouse2.50066673
11AR_21909140_ChIP-Seq_LNCAP_Human2.46373509
12NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.40303980
13NRF2_20460467_ChIP-Seq_MEFs_Mouse2.40303980
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.32942969
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.32596533
16PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.22685742
17* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.21675379
18WT1_19549856_ChIP-ChIP_CCG9911_Human2.14365210
19* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.12593677
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.11096736
21ZNF263_19887448_ChIP-Seq_K562_Human2.08663539
22SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.08108535
23SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.08108535
24DCP1A_22483619_ChIP-Seq_HELA_Human2.05260886
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03133515
26OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.98893449
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.95985587
28ELK1_19687146_ChIP-ChIP_HELA_Human1.94480838
29* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.88023164
30TFEB_21752829_ChIP-Seq_HELA_Human1.84150593
31ETS1_20019798_ChIP-Seq_JURKAT_Human1.82071300
32SOX2_20726797_ChIP-Seq_SW620_Human1.77156286
33VDR_22108803_ChIP-Seq_LS180_Human1.75438021
34HIF1A_21447827_ChIP-Seq_MCF-7_Human1.71953372
35* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.70942305
36SRF_21415370_ChIP-Seq_HL-1_Mouse1.69860764
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.68187090
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.67206742
39CJUN_26792858_Chip-Seq_BT549_Human1.66259715
40E2F7_22180533_ChIP-Seq_HELA_Human1.65577421
41EP300_21415370_ChIP-Seq_HL-1_Mouse1.64957858
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.64288619
43SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.61870287
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.58677116
45SALL4_18804426_ChIP-ChIP_XEN_Mouse1.56458852
46HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.55964791
47GABP_19822575_ChIP-Seq_HepG2_Human1.54298764
48PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.54257741
49SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.54026097
50* EOMES_21245162_ChIP-Seq_HESCs_Human1.53679808
51* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53489535
52PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.52159842
53BRD4_25478319_ChIP-Seq_HGPS_Human1.51535410
54EST1_17652178_ChIP-ChIP_JURKAT_Human1.50899887
55ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.50460163
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.50297714
57GBX2_23144817_ChIP-Seq_PC3_Human1.49938871
58FOXO3_23340844_ChIP-Seq_DLD1_Human1.49423218
59TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48391433
60* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47170293
61VDR_23849224_ChIP-Seq_CD4+_Human1.46693267
62RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.40644236
63NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.37907405
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.36685997
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35202754
66* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.31714617
67SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.30903356
68ESR2_21235772_ChIP-Seq_MCF-7_Human1.29895943
69MYCN_18555785_ChIP-Seq_MESCs_Mouse1.29843908
70RARG_19884340_ChIP-ChIP_MEFs_Mouse1.29389152
71GATA2_21666600_ChIP-Seq_HMVEC_Human1.28842431
72Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.28739670
73VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.27732023
74SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27480547
75ELK1_22589737_ChIP-Seq_MCF10A_Human1.27055145
76CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.26530233
77ER_23166858_ChIP-Seq_MCF-7_Human1.25301007
78* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.24960585
79* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.24261905
80PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23732572
81SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.22942871
82MTF2_20144788_ChIP-Seq_MESCs_Mouse1.19748298
83NANOG_18555785_ChIP-Seq_MESCs_Mouse1.19224993
84ATF3_27146783_Chip-Seq_COLON_Human1.18713324
85HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.17599347
86ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17560478
87TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15950022
88XRN2_22483619_ChIP-Seq_HELA_Human1.15587783
89KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15539620
90SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14277132
91SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.13807604
92FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13734755
93PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13715348
94CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.13527512
95TP63_23658742_ChIP-Seq_EP156T_Human1.13279473
96TAF15_26573619_Chip-Seq_HEK293_Human1.13044991
97NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.11966997
98* UBF1/2_26484160_Chip-Seq_HMECs_Human1.11820423
99SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.11594621
100STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.10646896
101SOX2_27498859_Chip-Seq_STOMACH_Mouse1.10427774
102NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10187021
103HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.09265876
104SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.08235409
105* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08171837
106POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07936067
107* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07511702
108DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06238641
109AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06222036
110MYC_19079543_ChIP-ChIP_MESCs_Mouse1.05340454
111SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.05254586
112AR_21572438_ChIP-Seq_LNCaP_Human1.05251822
113PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.04929622
114CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04630120
115CHD1_26751641_Chip-Seq_LNCaP_Human1.04253898
116ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03663196
117CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03296565
118TP53_18474530_ChIP-ChIP_U2OS_Human1.03038268
119ELF5_23300383_ChIP-Seq_T47D_Human1.02483463
120ELK3_25401928_ChIP-Seq_HUVEC_Human1.02311369
121FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.01690469
122PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01658603
123* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.01610077
124CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01495977
125TTF2_22483619_ChIP-Seq_HELA_Human1.01218618
126ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01056996
127* FOXP3_21729870_ChIP-Seq_TREG_Human1.00990011
128EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00026410
129* SOX2_19829295_ChIP-Seq_ESCs_Human0.99679942
130* NANOG_19829295_ChIP-Seq_ESCs_Human0.99679942
131CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99589886
132* LXR_22158963_ChIP-Seq_LIVER_Mouse0.99475377
133STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99300225
134ZFP57_27257070_Chip-Seq_ESCs_Mouse0.99079933
135* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98255575
136TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98079052
137PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.97444269
138NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.97361268
139FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.97154316
140SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.96901976
141NOTCH1_21737748_ChIP-Seq_TLL_Human0.96767206
142FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95925409
143TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.95647292
144KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.95192351
145KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.95192351
146KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.95192351
147EED_16625203_ChIP-ChIP_MESCs_Mouse0.94894879
148* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94618906
149* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.94280106
150* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94069054
151CLOCK_20551151_ChIP-Seq_293T_Human0.92385964
152SOX17_20123909_ChIP-Seq_XEN_Mouse0.92378618
153TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92297035
154FOXA1_25552417_ChIP-Seq_VCAP_Human0.91950826
155PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91804468
156GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90498362
157SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.87215787
158MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86260005
159FOXA1_21572438_ChIP-Seq_LNCaP_Human0.86143790
160SMAD3_21741376_ChIP-Seq_EPCs_Human0.85566175
161EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.83951117
162RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.83578544
163RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.83330408
164BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79717750
165ESR1_20079471_ChIP-ChIP_T-47D_Human0.79438180
166NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.79115351
167STAT3_23295773_ChIP-Seq_U87_Human0.78704970
168EZH2_18974828_ChIP-Seq_MESCs_Mouse0.78367625
169RNF2_18974828_ChIP-Seq_MESCs_Mouse0.78367625
170TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.78328164
171MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.78214556
172TP63_17297297_ChIP-ChIP_HaCaT_Human0.78036899
173LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77173105
174SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.77151908
175IRF8_21731497_ChIP-ChIP_J774_Mouse0.77099842
176ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.76948884

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.10297783
2MP0008438_abnormal_cutaneous_collagen4.14173428
3MP0003950_abnormal_plasma_membrane3.83277595
4MP0002796_impaired_skin_barrier3.55472012
5MP0003705_abnormal_hypodermis_morpholog3.05399414
6MP0005058_abnormal_lysosome_morphology3.00465174
7MP0003690_abnormal_glial_cell3.00426192
8MP0003195_calcinosis2.91894444
9MP0003329_amyloid_beta_deposits2.79696520
10MP0006054_spinal_hemorrhage2.79580872
11MP0003566_abnormal_cell_adhesion2.76111650
12MP0003806_abnormal_nucleotide_metabolis2.65360591
13MP0004043_abnormal_pH_regulation2.60892393
14MP0002060_abnormal_skin_morphology2.47889450
15MP0005501_abnormal_skin_physiology2.40808573
16MP0003634_abnormal_glial_cell2.31392713
17MP0002295_abnormal_pulmonary_circulatio2.31035904
18MP0004272_abnormal_basement_membrane2.23789632
19MP0004270_analgesia2.16459556
20MP0005171_absent_coat_pigmentation2.10541282
21MP0003941_abnormal_skin_development2.06538980
22MP0000013_abnormal_adipose_tissue2.01676159
23MP0005451_abnormal_body_composition1.91756295
24MP0002877_abnormal_melanocyte_morpholog1.87376509
25MP0000604_amyloidosis1.84688559
26MP0003191_abnormal_cellular_cholesterol1.82548046
27MP0001299_abnormal_eye_distance/1.74495701
28MP0001216_abnormal_epidermal_layer1.73943624
29MP0005408_hypopigmentation1.66043346
30MP0004947_skin_inflammation1.64263602
31MP0003136_yellow_coat_color1.61089031
32MP0010234_abnormal_vibrissa_follicle1.59592934
33MP0001905_abnormal_dopamine_level1.58995423
34MP0009840_abnormal_foam_cell1.58360285
35MP0003448_altered_tumor_morphology1.58179251
36MP0000462_abnormal_digestive_system1.56385175
37MP0005023_abnormal_wound_healing1.52244075
38MP0005275_abnormal_skin_tensile1.50561268
39MP0001661_extended_life_span1.48920782
40MP0004885_abnormal_endolymph1.48810566
41MP0001853_heart_inflammation1.46693195
42MP0004742_abnormal_vestibular_system1.45834189
43MP0000015_abnormal_ear_pigmentation1.44129402
44MP0003172_abnormal_lysosome_physiology1.43206936
45MP0003632_abnormal_nervous_system1.41452656
46MP0006082_CNS_inflammation1.41029166
47MP0002166_altered_tumor_susceptibility1.40432271
48MP0010771_integument_phenotype1.39916559
49MP0010352_gastrointestinal_tract_polyps1.39639700
50MP0004233_abnormal_muscle_weight1.35501653
51MP0008260_abnormal_autophagy1.35159974
52MP0000003_abnormal_adipose_tissue1.35148919
53MP0005623_abnormal_meninges_morphology1.34548667
54MP0002933_joint_inflammation1.32643877
55MP0003186_abnormal_redox_activity1.32352471
56MP0002006_tumorigenesis1.31313099
57MP0001879_abnormal_lymphatic_vessel1.28831403
58MP0009384_cardiac_valve_regurgitation1.28446818
59MP0005165_increased_susceptibility_to1.27751170
60MP0001958_emphysema1.26905141
61MP0001529_abnormal_vocalization1.26173326
62MP0000858_altered_metastatic_potential1.25772520
63MP0001851_eye_inflammation1.25064609
64MP0002229_neurodegeneration1.23119086
65MP0010678_abnormal_skin_adnexa1.23040580
66MP0009780_abnormal_chondrocyte_physiolo1.19800377
67MP0003828_pulmonary_edema1.18313573
68MP0010386_abnormal_urinary_bladder1.18207039
69MP0005197_abnormal_uvea_morphology1.17247035
70MP0005503_abnormal_tendon_morphology1.15916651
71MP0001542_abnormal_bone_strength1.14999299
72MP0000767_abnormal_smooth_muscle1.14629195
73MP0001485_abnormal_pinna_reflex1.13180100
74MP0009053_abnormal_anal_canal1.12768119
75MP0003279_aneurysm1.11298380
76MP0003724_increased_susceptibility_to1.11198624
77MP0002148_abnormal_hypersensitivity_rea1.09132820
78MP0004185_abnormal_adipocyte_glucose1.08264246
79MP0002102_abnormal_ear_morphology1.08023923
80MP0008007_abnormal_cellular_replicative1.07891616
81MP0001191_abnormal_skin_condition1.07316527
82MP0000383_abnormal_hair_follicle1.05542896
83MP0000343_altered_response_to1.04730094
84MP0004142_abnormal_muscle_tone1.03587662
85MP0000747_muscle_weakness1.01485674
86MP0000749_muscle_degeneration0.98652513
87MP0003183_abnormal_peptide_metabolism0.98082749
88MP0001348_abnormal_lacrimal_gland0.96870916
89MP0000647_abnormal_sebaceous_gland0.94984980
90MP0003283_abnormal_digestive_organ0.94124037
91MP0003786_premature_aging0.93980482
92MP0005164_abnormal_response_to0.93272310
93MP0005257_abnormal_intraocular_pressure0.93162646
94MP0000358_abnormal_cell_content/0.92433931
95MP0004957_abnormal_blastocyst_morpholog0.92158151
96MP0002272_abnormal_nervous_system0.91432108
97MP0004134_abnormal_chest_morphology0.91341580
98MP0001346_abnormal_lacrimal_gland0.89218535
99MP0001243_abnormal_dermal_layer0.87685898
100MP0005083_abnormal_biliary_tract0.87516661
101MP0000377_abnormal_hair_follicle0.87178519
102MP0002734_abnormal_mechanical_nocicepti0.86565585
103MP0003631_nervous_system_phenotype0.86406126
104MP0002177_abnormal_outer_ear0.86088984
105MP0004147_increased_porphyrin_level0.85626568
106MP0005508_abnormal_skeleton_morphology0.85025277
107MP0009931_abnormal_skin_appearance0.84542888
108MP0004858_abnormal_nervous_system0.84335222
109MP0004782_abnormal_surfactant_physiolog0.84140736
110MP0005390_skeleton_phenotype0.83876575
111MP0005193_abnormal_anterior_eye0.82837049
112MP0002095_abnormal_skin_pigmentation0.81338165
113MP0001533_abnormal_skeleton_physiology0.81330828
114MP0002837_dystrophic_cardiac_calcinosis0.79741269
115MP0000762_abnormal_tongue_morphology0.79684427
116MP0002254_reproductive_system_inflammat0.79498058
117MP0005174_abnormal_tail_pigmentation0.78724387
118MP0001881_abnormal_mammary_gland0.78554208
119MP0009643_abnormal_urine_homeostasis0.78536638
120MP0005647_abnormal_sex_gland0.78390093
121MP0000627_abnormal_mammary_gland0.78182065
122MP0000579_abnormal_nail_morphology0.78066970
123MP0010030_abnormal_orbit_morphology0.77991315
124MP0003453_abnormal_keratinocyte_physiol0.77811985
125MP0003011_delayed_dark_adaptation0.77648408
126MP0009333_abnormal_splenocyte_physiolog0.77097376
127MP0008932_abnormal_embryonic_tissue0.75405298
128MP0005379_endocrine/exocrine_gland_phen0.75187306
129MP0005595_abnormal_vascular_smooth0.73940654
130MP0001986_abnormal_taste_sensitivity0.73783980
131MP0003633_abnormal_nervous_system0.73566583
132MP0000372_irregular_coat_pigmentation0.72976625
133MP0002118_abnormal_lipid_homeostasis0.72837525
134MP0005388_respiratory_system_phenotype0.72143200
135MP0002133_abnormal_respiratory_system0.72143200
136MP0010368_abnormal_lymphatic_system0.70652177
137MP0003937_abnormal_limbs/digits/tail_de0.70452418
138MP0005332_abnormal_amino_acid0.70409895
139MP0002090_abnormal_vision0.70246694
140MP0002009_preneoplasia0.70127931
141MP0001727_abnormal_embryo_implantation0.69861204
142MP0001970_abnormal_pain_threshold0.69708969
143MP0000230_abnormal_systemic_arterial0.69179134
144MP0002998_abnormal_bone_remodeling0.68416615
145MP0000613_abnormal_salivary_gland0.68042472
146MP0002098_abnormal_vibrissa_morphology0.67657852
147MP0000639_abnormal_adrenal_gland0.66905376
148MP0004036_abnormal_muscle_relaxation0.66603233
149MP0003075_altered_response_to0.65421259
150MP0000467_abnormal_esophagus_morphology0.64952754
151MP0009250_abnormal_appendicular_skeleto0.64778547
152MP0009785_altered_susceptibility_to0.64319922
153MP0008058_abnormal_DNA_repair0.64101596
154MP0003315_abnormal_perineum_morphology0.63890507
155MP0002896_abnormal_bone_mineralization0.63852419
156MP0005410_abnormal_fertilization0.63816241
157MP0003795_abnormal_bone_structure0.63338858
158MP0003091_abnormal_cell_migration0.63081507
159MP0005375_adipose_tissue_phenotype0.62708672
160MP0000955_abnormal_spinal_cord0.62519077

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)5.91956943
2Follicular hyperkeratosis (HP:0007502)5.03753568
3Degeneration of the lateral corticospinal tracts (HP:0002314)5.00522958
4Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.00522958
5Parakeratosis (HP:0001036)4.12608697
6Cerebral inclusion bodies (HP:0100314)4.10275541
7Protrusio acetabuli (HP:0003179)3.94582310
8Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.92446413
9Premature rupture of membranes (HP:0001788)3.62240584
10Ankle contracture (HP:0006466)3.60374617
11Sensory axonal neuropathy (HP:0003390)3.59169329
12Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.51217352
13Vertebral compression fractures (HP:0002953)3.51041359
14Onycholysis (HP:0001806)3.48958402
15Alopecia of scalp (HP:0002293)3.36593804
16Abnormality of the corticospinal tract (HP:0002492)3.34944410
17Autoamputation (HP:0001218)3.23322601
18Onion bulb formation (HP:0003383)3.14750620
19Sparse eyelashes (HP:0000653)3.06958169
20Hypotrichosis (HP:0001006)2.99625345
21Vacuolated lymphocytes (HP:0001922)2.96292175
22Palmoplantar hyperkeratosis (HP:0000972)2.96149573
23Supranuclear gaze palsy (HP:0000605)2.94994813
24Dysostosis multiplex (HP:0000943)2.92061206
25Atrophic scars (HP:0001075)2.91924851
26Peripheral hypomyelination (HP:0007182)2.91109302
27Abnormality of the axillary hair (HP:0100134)2.91100061
28Abnormality of secondary sexual hair (HP:0009888)2.91100061
29Hypokinesia (HP:0002375)2.90842267
30Aortic dissection (HP:0002647)2.89822239
31Termporal pattern (HP:0011008)2.86184230
32Insidious onset (HP:0003587)2.86184230
33Segmental peripheral demyelination/remyelination (HP:0003481)2.85270344
34Erythema (HP:0010783)2.83232724
35Axonal loss (HP:0003447)2.81694583
36Palmar hyperkeratosis (HP:0010765)2.80861618
37Reduced subcutaneous adipose tissue (HP:0003758)2.80778102
38Soft skin (HP:0000977)2.72243631
39Plantar hyperkeratosis (HP:0007556)2.71459128
40Erythroderma (HP:0001019)2.70566976
41Entropion (HP:0000621)2.68795573
42Increased neuronal autofluorescent lipopigment (HP:0002074)2.68701983
43Conjunctival hamartoma (HP:0100780)2.61770173
44Hyperinsulinemic hypoglycemia (HP:0000825)2.59460672
45Congenital ichthyosiform erythroderma (HP:0007431)2.59460096
46Aplastic anemia (HP:0001915)2.58748916
47Abnormality of the distal phalanges of the toes (HP:0010182)2.58393649
48Retinal dysplasia (HP:0007973)2.58083445
49Abnormality of aromatic amino acid family metabolism (HP:0004338)2.57939044
50Cerebral hemorrhage (HP:0001342)2.53252406
51Cerebral hypomyelination (HP:0006808)2.52530007
52Type I transferrin isoform profile (HP:0003642)2.51829269
53Increased cerebral lipofuscin (HP:0011813)2.51797956
54Progressive neurologic deterioration (HP:0002344)2.49270663
55Elbow flexion contracture (HP:0002987)2.48592981
56Nonimmune hydrops fetalis (HP:0001790)2.48559344
57Abnormality of nail color (HP:0100643)2.47093598
58Degeneration of anterior horn cells (HP:0002398)2.46898343
59Abnormality of the anterior horn cell (HP:0006802)2.46898343
60Increased circulating renin level (HP:0000848)2.46852873
61Bladder diverticulum (HP:0000015)2.45886031
62Premature skin wrinkling (HP:0100678)2.43290483
63Hypomagnesemia (HP:0002917)2.43208315
64Cervical subluxation (HP:0003308)2.41352847
65Stridor (HP:0010307)2.39886998
66Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.39686871
67Abnormal protein N-linked glycosylation (HP:0012347)2.39686871
68Abnormal protein glycosylation (HP:0012346)2.39686871
69Abnormal glycosylation (HP:0012345)2.39686871
70Pheochromocytoma (HP:0002666)2.37455309
71Hepatosplenomegaly (HP:0001433)2.35226026
72Nail dystrophy (HP:0008404)2.35152307
73Hypokalemic alkalosis (HP:0001949)2.35077502
74Abnormal auditory evoked potentials (HP:0006958)2.30524125
75Osteolytic defects of the hand bones (HP:0009699)2.28956491
76Osteolytic defects of the phalanges of the hand (HP:0009771)2.28956491
77Abnormality of glycolysis (HP:0004366)2.28492576
78Increased serum pyruvate (HP:0003542)2.28492576
79Redundant skin (HP:0001582)2.28364358
80Abnormality of liposaccharide metabolism (HP:0010968)2.28332995
81Abnormality of glycosphingolipid metabolism (HP:0004343)2.28332995
82Abnormality of glycolipid metabolism (HP:0010969)2.28332995
83Coronal craniosynostosis (HP:0004440)2.27999748
84Abnormality of the umbilical cord (HP:0010881)2.27380886
85Upper motor neuron abnormality (HP:0002127)2.27366205
86Aplasia of the phalanges of the hand (HP:0009802)2.27217630
87Aplasia involving bones of the extremities (HP:0009825)2.27217630
88Aplasia involving bones of the upper limbs (HP:0009823)2.27217630
89Fragile skin (HP:0001030)2.25250971
90Hypoglycemic seizures (HP:0002173)2.25123908
91Tetraparesis (HP:0002273)2.23964655
92Blue sclerae (HP:0000592)2.23700089
93Microretrognathia (HP:0000308)2.21717490
94Abnormal umbilical cord blood vessels (HP:0011403)2.19089032
95Single umbilical artery (HP:0001195)2.19089032
96Abnormality of the fetal cardiovascular system (HP:0010948)2.19089032
97Generalized amyotrophy (HP:0003700)2.18595200
98Spinal rigidity (HP:0003306)2.17292469
99Thickened helices (HP:0000391)2.15828649
100Spastic gait (HP:0002064)2.15672622
101Thick nail (HP:0001805)2.15296895
102Alacrima (HP:0000522)2.14510639
103Ectropion (HP:0000656)2.13756264
104Episodic fever (HP:0001954)2.12987169
105Natal tooth (HP:0000695)2.12857887
106Spastic paraparesis (HP:0002313)2.12613273
107Fragile nails (HP:0001808)2.11783973
108Loss of speech (HP:0002371)2.10727968
109Symptomatic seizures (HP:0011145)2.10374007
110Neuroendocrine neoplasm (HP:0100634)2.10225145
111Genu recurvatum (HP:0002816)2.08724219
112Selective tooth agenesis (HP:0001592)2.08077960
113Akinesia (HP:0002304)2.05266184
114Esophageal neoplasm (HP:0100751)2.05203486
115Neoplasm of head and neck (HP:0012288)2.05203486
116Intention tremor (HP:0002080)2.04752217
117Anteriorly placed anus (HP:0001545)2.04731450
118Abnormality of magnesium homeostasis (HP:0004921)2.04583705
119Abnormality of dentin (HP:0010299)2.03718686
120Clumsiness (HP:0002312)2.03478852
121Trismus (HP:0000211)2.03104570
122Mucopolysacchariduria (HP:0008155)2.02432804
123Urinary glycosaminoglycan excretion (HP:0003541)2.02432804
124Short clavicles (HP:0000894)2.01526345
125Reduced antithrombin III activity (HP:0001976)1.99280888
126Poor head control (HP:0002421)1.96898842
127Muscle fiber splitting (HP:0003555)1.95829038
128Split foot (HP:0001839)1.94867092
129Increased IgE level (HP:0003212)1.94557535
130Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.94250387
131Abnormality of alanine metabolism (HP:0010916)1.94250387
132Hyperalaninemia (HP:0003348)1.94250387
133Woolly hair (HP:0002224)1.94233120
134Slow saccadic eye movements (HP:0000514)1.94053279
135Peripheral demyelination (HP:0011096)1.93725471
136Patchy hypopigmentation of hair (HP:0011365)1.91883816
137Anhidrosis (HP:0000970)1.91347689
138Protuberant abdomen (HP:0001538)1.91140835
139Prolonged neonatal jaundice (HP:0006579)1.90520690
140Oral leukoplakia (HP:0002745)1.90512507
141Mitral stenosis (HP:0001718)1.90109334
142Cardiovascular calcification (HP:0011915)1.89625629
143Infantile muscular hypotonia (HP:0008947)1.89322343
144Foot dorsiflexor weakness (HP:0009027)1.88772422
145Disproportionate short-trunk short stature (HP:0003521)1.87359352
146Corneal erosion (HP:0200020)1.85945674
147Spondylolisthesis (HP:0003302)1.85823641
148Amyloidosis (HP:0011034)1.83897737
149Aortic aneurysm (HP:0004942)1.82636703
150Arterial tortuosity (HP:0005116)1.82536475
151Leukodystrophy (HP:0002415)1.81557322
152Barrel-shaped chest (HP:0001552)1.81545525
153Hypoglycemic coma (HP:0001325)1.80987817
154Hyporeflexia of lower limbs (HP:0002600)1.80945805
155Hypophosphatemic rickets (HP:0004912)1.80856933
156Vascular tortuosity (HP:0004948)1.80838045
157Gowers sign (HP:0003391)1.79846073
158Humeroradial synostosis (HP:0003041)1.79518162
159Synostosis involving the elbow (HP:0003938)1.79518162
160Abnormality of polysaccharide metabolism (HP:0011012)1.79045112
161Abnormality of glycosaminoglycan metabolism (HP:0004371)1.79045112
162Abnormality of mucopolysaccharide metabolism (HP:0011020)1.79045112
163Abnormality of the middle phalanges of the toes (HP:0010183)1.78596249
164Short middle phalanx of the 5th finger (HP:0004220)1.78468470
165Abnormality of macrophages (HP:0004311)1.77893726
166Dysmetria (HP:0001310)1.77837213
167Dilatation of the ascending aorta (HP:0005111)1.77795660
168Hypoplasia of the odontoid process (HP:0003311)1.77664256
169Wormian bones (HP:0002645)1.77086938
170Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.77067998
171Adrenal hypoplasia (HP:0000835)1.76017138
172Metabolic alkalosis (HP:0200114)1.73853623
173Peritonitis (HP:0002586)1.72766802
174Hypoplasia of the iris (HP:0007676)1.72753733
175Pancreatic islet-cell hyperplasia (HP:0004510)1.71585098
176Abnormality of the phalanges of the 2nd finger (HP:0009541)1.71441628
177Methylmalonic acidemia (HP:0002912)1.70412857
178Intrahepatic cholestasis (HP:0001406)1.65158164
179Large for gestational age (HP:0001520)1.64457207
180Fused cervical vertebrae (HP:0002949)1.64203950
181Type II lissencephaly (HP:0007260)1.64142685
182Hypoplastic pelvis (HP:0008839)1.62363916

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.65650125
2OXSR14.02308059
3PDK23.68144013
4EPHB13.55752660
5MET3.12345923
6WNK42.96054422
7PBK2.95546123
8LIMK12.94017648
9BCR2.90722295
10MYLK2.65263669
11NTRK12.49665761
12BUB12.43840867
13TESK22.37398525
14NME22.30552921
15NEK12.28786617
16WEE12.26020952
17BRSK22.22513485
18MAP3K122.15613892
19MAP3K32.11211179
20WNK11.99976201
21TGFBR21.98099099
22PAK41.95392054
23PIM21.90459778
24MAPKAPK51.90185046
25NEK91.88899800
26INSRR1.87039619
27IRAK31.83515155
28TRIM281.82816368
29SIK31.81813735
30ERBB31.76200968
31ARAF1.75535164
32FGFR21.74958799
33PKN11.68479550
34MST41.59690510
35EPHA21.56856847
36MOS1.56015325
37MAPK151.48821201
38NEK61.48501010
39CSNK1G31.46110752
40TAOK21.45163040
41CSNK1A1L1.43867415
42EIF2AK11.42654637
43ERBB41.40651181
44BRSK11.37357044
45ROCK21.35202700
46GRK11.32289949
47PAK31.31817375
48GRK71.26474839
49MAP3K141.25176519
50TRPM71.22403563
51TSSK61.21242182
52SCYL21.21146906
53CAMK2B1.20817066
54CAMK2D1.18691196
55SRPK11.18572248
56BCKDK1.17544774
57CSNK1G11.12632170
58MAP3K21.09470893
59PRPF4B1.06137967
60FGR1.04665545
61PTK21.03818474
62NUAK11.03658941
63CDK191.03132704
64ILK1.01747358
65MAPKAPK30.99153379
66KSR20.99145158
67CSNK1G20.97156397
68CAMK2G0.92965055
69RAF10.87860986
70UHMK10.87595641
71PAK60.86862236
72EIF2AK30.86586114
73IRAK10.85563168
74BMPR1B0.83303871
75PRKCE0.80589492
76ABL20.79622834
77CDK140.79544128
78MAP2K20.79223008
79LATS10.79018933
80BMPR20.78584295
81PRKD10.78252786
82TESK10.77474110
83TAOK30.77019224
84MST1R0.74537543
85SGK4940.74362412
86SGK2230.74362412
87PLK20.73829500
88CDK80.73243355
89PDGFRA0.72696524
90CLK10.72458752
91DYRK20.71462027
92HIPK20.71038170
93TXK0.70736423
94EIF2AK20.69385942
95IKBKB0.68392837
96STK100.68029200
97DDR20.67806983
98ERN10.66372777
99TBK10.66052286
100VRK20.65479187
101PRKD20.64515560
102PRKCQ0.62977637
103GSK3A0.62955001
104IRAK40.62909614
105PRKCH0.61971588
106PRKD30.60088694
107BRAF0.60080015
108FLT30.59576809
109MAP3K130.59526506
110EPHA30.59497670
111CAMK2A0.59474148
112TGFBR10.58814190
113MAP3K80.58554219
114CSK0.58537634
115ITK0.58053289
116IRAK20.55537429
117CDK70.53948833
118CDK150.51106118
119PDPK10.50926320
120DAPK30.50894670
121CDK60.50510243
122PDGFRB0.49156741
123MAP3K10.49055914
124STK380.48544640
125FER0.48319653
126AKT30.47560537
127TIE10.47523473
128CDK180.47450897
129DAPK10.46805952
130PAK10.46720335
131INSR0.46427600
132PLK30.46257983
133TYK20.45758542
134PTK2B0.45647522
135TYRO30.45547949
136STK160.45427241
137RPS6KA50.43128426
138PAK20.42394423
139LATS20.42350127
140CDK11A0.42033740
141FYN0.41522033
142KDR0.40808279
143LRRK20.38381787
144BMX0.37938187
145PIK3CA0.37758309
146CSNK1A10.37647699
147ADRBK10.37288884
148PIK3CG0.35953239
149PLK10.35497982
150CDK50.35045592
151PRKG10.34426670
152ROCK10.34193782
153CAMKK20.32179477
154MAP2K10.31600765
155AURKB0.31450614
156ABL10.31363979
157MARK30.28689255
158MAPKAPK20.27971476
159RET0.27758561
160BLK0.27191458
161IGF1R0.27127780
162JAK10.26949879

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.73304362
2Steroid biosynthesis_Homo sapiens_hsa001004.56575509
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.52501254
4Protein export_Homo sapiens_hsa030604.29715750
5Fatty acid elongation_Homo sapiens_hsa000623.86194215
6Sulfur metabolism_Homo sapiens_hsa009203.00429089
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.74401675
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.62956443
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.58946820
10Ether lipid metabolism_Homo sapiens_hsa005652.53793829
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.39322191
12Lysosome_Homo sapiens_hsa041422.24110118
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.12108722
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.07545980
15Caffeine metabolism_Homo sapiens_hsa002321.91053960
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.87779376
17Vibrio cholerae infection_Homo sapiens_hsa051101.82918777
18Histidine metabolism_Homo sapiens_hsa003401.79824927
19* Sphingolipid metabolism_Homo sapiens_hsa006001.77566312
20N-Glycan biosynthesis_Homo sapiens_hsa005101.75427023
21Oxidative phosphorylation_Homo sapiens_hsa001901.62868112
22DNA replication_Homo sapiens_hsa030301.45097364
23Phagosome_Homo sapiens_hsa041451.44793593
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.44128150
25Vitamin B6 metabolism_Homo sapiens_hsa007501.43959726
26RNA polymerase_Homo sapiens_hsa030201.40487868
27Linoleic acid metabolism_Homo sapiens_hsa005911.38526694
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.34376673
29Rheumatoid arthritis_Homo sapiens_hsa053231.33640238
30p53 signaling pathway_Homo sapiens_hsa041151.33196942
31Other glycan degradation_Homo sapiens_hsa005111.31942973
32Pyrimidine metabolism_Homo sapiens_hsa002401.31141027
33Folate biosynthesis_Homo sapiens_hsa007901.29709415
34Collecting duct acid secretion_Homo sapiens_hsa049661.27791866
35SNARE interactions in vesicular transport_Homo sapiens_hsa041301.27598339
36Legionellosis_Homo sapiens_hsa051341.26431992
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.26220965
38Pyruvate metabolism_Homo sapiens_hsa006201.23769446
39Nucleotide excision repair_Homo sapiens_hsa034201.22562776
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.18295413
41One carbon pool by folate_Homo sapiens_hsa006701.17799954
42Arginine and proline metabolism_Homo sapiens_hsa003301.16898571
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.16829758
44Malaria_Homo sapiens_hsa051441.16573523
45Butanoate metabolism_Homo sapiens_hsa006501.16000359
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.12953711
47Renal cell carcinoma_Homo sapiens_hsa052111.11410737
48Base excision repair_Homo sapiens_hsa034101.10468429
49Bladder cancer_Homo sapiens_hsa052191.04190946
50Mismatch repair_Homo sapiens_hsa034301.03086428
51Glycosaminoglycan degradation_Homo sapiens_hsa005311.00258255
52Small cell lung cancer_Homo sapiens_hsa052220.99733690
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97092304
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95987465
55Glutathione metabolism_Homo sapiens_hsa004800.95524836
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94913724
57ECM-receptor interaction_Homo sapiens_hsa045120.94894846
58Parkinsons disease_Homo sapiens_hsa050120.90856386
59Alzheimers disease_Homo sapiens_hsa050100.90487749
60Arachidonic acid metabolism_Homo sapiens_hsa005900.89308083
61Pentose phosphate pathway_Homo sapiens_hsa000300.89134470
62Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.88887062
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86397432
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86219839
65Carbon metabolism_Homo sapiens_hsa012000.85213147
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.84900685
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84257073
68Galactose metabolism_Homo sapiens_hsa000520.84157785
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83351510
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82617944
71Peroxisome_Homo sapiens_hsa041460.81894039
72Axon guidance_Homo sapiens_hsa043600.80623149
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80487218
74Endocytosis_Homo sapiens_hsa041440.79720203
75Fatty acid metabolism_Homo sapiens_hsa012120.79408421
76Mineral absorption_Homo sapiens_hsa049780.78342436
77Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75123201
78RNA transport_Homo sapiens_hsa030130.75002250
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73596062
80Viral myocarditis_Homo sapiens_hsa054160.72925818
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72186949
82Biosynthesis of amino acids_Homo sapiens_hsa012300.72151006
83Tight junction_Homo sapiens_hsa045300.70895366
84Antigen processing and presentation_Homo sapiens_hsa046120.69516556
85TNF signaling pathway_Homo sapiens_hsa046680.68748614
86* Sphingolipid signaling pathway_Homo sapiens_hsa040710.62920556
87Basal transcription factors_Homo sapiens_hsa030220.62692325
88Renin-angiotensin system_Homo sapiens_hsa046140.62498996
89Tyrosine metabolism_Homo sapiens_hsa003500.62437484
90Prion diseases_Homo sapiens_hsa050200.61191150
91Toxoplasmosis_Homo sapiens_hsa051450.60908484
92Serotonergic synapse_Homo sapiens_hsa047260.60824330
93Ovarian steroidogenesis_Homo sapiens_hsa049130.60787917
94Sulfur relay system_Homo sapiens_hsa041220.59536819
95Spliceosome_Homo sapiens_hsa030400.59256866
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56911010
97Cell cycle_Homo sapiens_hsa041100.56210016
98Regulation of autophagy_Homo sapiens_hsa041400.53739048
99Apoptosis_Homo sapiens_hsa042100.53289893
100Primary bile acid biosynthesis_Homo sapiens_hsa001200.52920564
101Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52549766
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52123639
103Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52052786
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51992086
105Nitrogen metabolism_Homo sapiens_hsa009100.51402088
106RNA degradation_Homo sapiens_hsa030180.51388862
107Ras signaling pathway_Homo sapiens_hsa040140.50864724
108Non-homologous end-joining_Homo sapiens_hsa034500.49596277
109Dorso-ventral axis formation_Homo sapiens_hsa043200.49250446
110Vitamin digestion and absorption_Homo sapiens_hsa049770.48923123
111Pancreatic secretion_Homo sapiens_hsa049720.48639161
112Protein digestion and absorption_Homo sapiens_hsa049740.48233871
113Propanoate metabolism_Homo sapiens_hsa006400.48218874
114Selenocompound metabolism_Homo sapiens_hsa004500.48036767
115Complement and coagulation cascades_Homo sapiens_hsa046100.47800652
116Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47617864
117Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47571096
118Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47408320
119Shigellosis_Homo sapiens_hsa051310.47327595
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.46475578
121Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46096381
122Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44310804
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.42802862
124Chemical carcinogenesis_Homo sapiens_hsa052040.42755083
125Focal adhesion_Homo sapiens_hsa045100.42745967
126Leukocyte transendothelial migration_Homo sapiens_hsa046700.41956706
127Autoimmune thyroid disease_Homo sapiens_hsa053200.41814320
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.41675561
129Phospholipase D signaling pathway_Homo sapiens_hsa040720.41536395
130Purine metabolism_Homo sapiens_hsa002300.40921087
131* Metabolic pathways_Homo sapiens_hsa011000.40860572
132Steroid hormone biosynthesis_Homo sapiens_hsa001400.39600567
133Fatty acid biosynthesis_Homo sapiens_hsa000610.39017806
134Cyanoamino acid metabolism_Homo sapiens_hsa004600.38920772
135TGF-beta signaling pathway_Homo sapiens_hsa043500.38859754
136Cocaine addiction_Homo sapiens_hsa050300.38023586
137Amoebiasis_Homo sapiens_hsa051460.37373095
138Pertussis_Homo sapiens_hsa051330.37149317
139Epstein-Barr virus infection_Homo sapiens_hsa051690.36403434
140RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.35881636
141Salmonella infection_Homo sapiens_hsa051320.31753426
142Tryptophan metabolism_Homo sapiens_hsa003800.30881775
143Asthma_Homo sapiens_hsa053100.27723780
144Staphylococcus aureus infection_Homo sapiens_hsa051500.27144816
145Phenylalanine metabolism_Homo sapiens_hsa003600.27036957
146Glycerolipid metabolism_Homo sapiens_hsa005610.26718234
147Prostate cancer_Homo sapiens_hsa052150.23705311
148Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.21304391
149Huntingtons disease_Homo sapiens_hsa050160.20913731
150Long-term depression_Homo sapiens_hsa047300.20688035
151Fatty acid degradation_Homo sapiens_hsa000710.20170070
152Proteoglycans in cancer_Homo sapiens_hsa052050.19348328
153Thyroid hormone synthesis_Homo sapiens_hsa049180.18741532

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