DEGS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a bifunctional enzyme that is involved in the biosynthesis of phytosphingolipids in human skin and in other phytosphingolipid-containing tissues. This enzyme can act as a sphingolipid delta(4)-desaturase, and also as a sphingolipid C4-hydroxylase. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)8.00407426
2cilium movement (GO:0003341)7.75918915
3cytidine metabolic process (GO:0046087)6.80631072
4cytidine catabolic process (GO:0006216)6.80631072
5cytidine deamination (GO:0009972)6.80631072
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.73038097
7motile cilium assembly (GO:0044458)6.66377510
8epithelial cilium movement (GO:0003351)6.60800641
9ribosomal small subunit biogenesis (GO:0042274)6.36081072
10viral transcription (GO:0019083)5.84747152
11polyketide metabolic process (GO:0030638)5.59282958
12doxorubicin metabolic process (GO:0044598)5.59282958
13daunorubicin metabolic process (GO:0044597)5.59282958
14translational termination (GO:0006415)5.39783293
15axoneme assembly (GO:0035082)5.30213843
16establishment of skin barrier (GO:0061436)5.26292424
17intestinal epithelial cell development (GO:0060576)5.14300495
18vitamin A metabolic process (GO:0006776)4.98439937
19regulation of water loss via skin (GO:0033561)4.97900263
20multicellular organismal water homeostasis (GO:0050891)4.97536688
21negative regulation of epidermis development (GO:0045683)4.85909477
22phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)4.82730914
23pyrimidine ribonucleoside catabolic process (GO:0046133)4.81298409
24primary alcohol catabolic process (GO:0034310)4.66737969
25negative regulation of telomerase activity (GO:0051974)4.61981860
26negative regulation of epidermal cell differentiation (GO:0045605)4.61487014
27ribosomal large subunit biogenesis (GO:0042273)4.60999776
28aminoglycoside antibiotic metabolic process (GO:0030647)4.59889593
29regulation of apoptotic process involved in morphogenesis (GO:1902337)4.59805292
30SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.53456475
31vitamin transmembrane transport (GO:0035461)4.51097724
32protein targeting to ER (GO:0045047)4.49219771
33viral life cycle (GO:0019058)4.45603760
34cotranslational protein targeting to membrane (GO:0006613)4.41449116
35desmosome organization (GO:0002934)4.36269687
36somite rostral/caudal axis specification (GO:0032525)4.34915337
37cellular protein complex disassembly (GO:0043624)4.28842183
38water homeostasis (GO:0030104)4.23124173
39establishment of protein localization to endoplasmic reticulum (GO:0072599)4.20616311
40interferon-gamma production (GO:0032609)4.12275952
41protein localization to endoplasmic reticulum (GO:0070972)4.07869241
42nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.06837454
43cardiovascular system development (GO:0072358)4.05885612
44translational elongation (GO:0006414)4.04608746
45GDP-mannose metabolic process (GO:0019673)4.01423689
46left/right pattern formation (GO:0060972)3.96043981
47ethanol metabolic process (GO:0006067)3.90897507
48antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.88725386
49tolerance induction (GO:0002507)3.83992236
50negative regulation of keratinocyte proliferation (GO:0010839)3.80539752
51protein complex disassembly (GO:0043241)3.75980413
52calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.71524264
53phenol-containing compound catabolic process (GO:0019336)3.67969527
54DNA damage response, detection of DNA damage (GO:0042769)3.67966461
55negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.67919196
56exogenous drug catabolic process (GO:0042738)3.64215877
57maintenance of protein location in nucleus (GO:0051457)3.57453737
58antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.57071020
59keratinization (GO:0031424)3.54741993
60macromolecular complex disassembly (GO:0032984)3.52680615
61transepithelial transport (GO:0070633)3.51805777
62regulation of MHC class I biosynthetic process (GO:0045343)3.46067310
63regulation of cilium movement (GO:0003352)3.44741145
64epoxygenase P450 pathway (GO:0019373)3.44597523
65epithelial cell maturation (GO:0002070)3.41925086
66negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.40474683
67ear development (GO:0043583)3.39238957
68phosphatidylserine acyl-chain remodeling (GO:0036150)3.37717964
69regulation of ruffle assembly (GO:1900027)3.35063994
70translational initiation (GO:0006413)3.33655093
71pyrimidine-containing compound transmembrane transport (GO:0072531)3.33180147
72maturation of SSU-rRNA (GO:0030490)3.31577201
73negative regulation of T cell differentiation in thymus (GO:0033085)3.31392236
74cardiac right ventricle morphogenesis (GO:0003215)3.30121920
75muscle organ morphogenesis (GO:0048644)3.28851629
76regulation of interleukin-5 production (GO:0032674)3.28708974
77hepatocyte apoptotic process (GO:0097284)3.28641940
78intra-S DNA damage checkpoint (GO:0031573)3.27860898
79notochord development (GO:0030903)3.27555519
80branching involved in mammary gland duct morphogenesis (GO:0060444)3.26341172
81forebrain neuron differentiation (GO:0021879)3.26203680
82rRNA transcription (GO:0009303)3.24892321
83sulfate transport (GO:0008272)3.21723406
84left/right axis specification (GO:0070986)3.20565100
85signal transduction involved in regulation of gene expression (GO:0023019)3.19880140
86drug catabolic process (GO:0042737)3.19139263
87regulation of interleukin-13 production (GO:0032656)3.17443323
88mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.17066780
89regulation of guanylate cyclase activity (GO:0031282)3.16745431
90positive regulation of epidermis development (GO:0045684)3.15785291
91mammary gland epithelial cell differentiation (GO:0060644)3.14689523
92negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.13434916
93regulation of autophagic vacuole assembly (GO:2000785)3.12959247
94trophectodermal cell differentiation (GO:0001829)3.08348338
95negative regulation of glial cell proliferation (GO:0060253)3.07425080
96sulfate transmembrane transport (GO:1902358)3.07303333
97sulfur compound transport (GO:0072348)3.04832594
98positive regulation of digestive system process (GO:0060456)3.04288023
99flavonoid metabolic process (GO:0009812)3.03521554
100heterochromatin organization (GO:0070828)3.03276289
101hormone catabolic process (GO:0042447)3.01294016
102regulation of nuclear cell cycle DNA replication (GO:0033262)3.00972188
103branching involved in labyrinthine layer morphogenesis (GO:0060670)3.00918732
104energy coupled proton transport, down electrochemical gradient (GO:0015985)3.00282629
105ATP synthesis coupled proton transport (GO:0015986)3.00282629
106regulation of mammary gland epithelial cell proliferation (GO:0033599)2.98918137
107ventricular system development (GO:0021591)2.98268184
108phosphatidylinositol acyl-chain remodeling (GO:0036149)2.95384121
109one-carbon compound transport (GO:0019755)2.95238027
110angiotensin maturation (GO:0002003)2.94938134
111inner ear receptor cell development (GO:0060119)2.92634598
112bone trabecula formation (GO:0060346)2.88744066
113lung epithelium development (GO:0060428)2.88600257
114antigen processing and presentation of endogenous antigen (GO:0019883)2.88047612
115purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.87567376
1163-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.87567376
117protein targeting to membrane (GO:0006612)2.86728686
118negative regulation of cell cycle G2/M phase transition (GO:1902750)2.86378072
119peptidyl-tyrosine autophosphorylation (GO:0038083)2.84914192
120response to xenobiotic stimulus (GO:0009410)2.83268656
121regulation of telomerase activity (GO:0051972)2.82869438
122positive regulation of epidermal cell differentiation (GO:0045606)2.81184030
123intestinal absorption (GO:0050892)2.80925723
124regulation of vitamin metabolic process (GO:0030656)2.80570940
125regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.80289666
126glandular epithelial cell differentiation (GO:0002067)2.79879039
127positive regulation of fatty acid beta-oxidation (GO:0032000)2.78962508
128regulation of microtubule-based movement (GO:0060632)2.76747862
129protein localization to cilium (GO:0061512)2.76515854
130sphingomyelin metabolic process (GO:0006684)2.75900088
131omega-hydroxylase P450 pathway (GO:0097267)2.75020709
132middle ear morphogenesis (GO:0042474)2.74749008
133regulation of hair follicle development (GO:0051797)2.74367806
134cilium organization (GO:0044782)2.73063499
135regulation of vacuole organization (GO:0044088)2.72954548
136negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.72491999
137maternal placenta development (GO:0001893)2.69425570
138primitive streak formation (GO:0090009)2.69119338
139positive regulation of keratinocyte differentiation (GO:0045618)2.68289099
140regulation of Golgi to plasma membrane protein transport (GO:0042996)2.67968348
141glutathione derivative biosynthetic process (GO:1901687)2.67962786
142glutathione derivative metabolic process (GO:1901685)2.67962786
143ncRNA 3-end processing (GO:0043628)2.67857780
144DNA replication checkpoint (GO:0000076)2.66584787
145O-glycan processing (GO:0016266)2.65830760
146cell differentiation involved in embryonic placenta development (GO:0060706)2.65476393
147prostate gland growth (GO:0060736)2.61908377
148regulation of epidermis development (GO:0045682)2.61852034
149negative regulation of telomere maintenance (GO:0032205)2.61519981
150establishment of apical/basal cell polarity (GO:0035089)2.61416238
151fat-soluble vitamin biosynthetic process (GO:0042362)2.60625799
152ribosomal small subunit assembly (GO:0000028)2.60532622
153establishment of tissue polarity (GO:0007164)2.60476988
154establishment of planar polarity (GO:0001736)2.60476988
155sodium ion homeostasis (GO:0055078)2.60278724
156very long-chain fatty acid metabolic process (GO:0000038)2.59928725
157behavioral response to nicotine (GO:0035095)2.59769306
158glutathione biosynthetic process (GO:0006750)2.59177343
159regulation of hydrogen peroxide metabolic process (GO:0010310)2.58890375
160positive regulation of respiratory burst (GO:0060267)2.58455195
161positive regulation of T cell differentiation in thymus (GO:0033089)2.58206734
162ribonucleoprotein complex biogenesis (GO:0022613)2.56874448
163cilium assembly (GO:0042384)2.56612153
164spliceosomal complex assembly (GO:0000245)2.56467839
165digestion (GO:0007586)2.55699408
166phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.53830675
167microtubule bundle formation (GO:0001578)2.52842627
168antibacterial humoral response (GO:0019731)2.52263275
169trivalent inorganic anion homeostasis (GO:0072506)2.50665359
170phosphate ion homeostasis (GO:0055062)2.50665359
171antimicrobial humoral response (GO:0019730)2.50108832
172columnar/cuboidal epithelial cell development (GO:0002066)2.49733401
173regulation of respiratory burst (GO:0060263)2.48286689
174ethanol oxidation (GO:0006069)2.46661045
175primary alcohol metabolic process (GO:0034308)2.45297506
176norepinephrine metabolic process (GO:0042415)2.44792939
177neurotransmitter biosynthetic process (GO:0042136)2.43620210
178drug metabolic process (GO:0017144)2.41553996
179phosphatidylcholine biosynthetic process (GO:0006656)2.41442297
180autophagic vacuole fusion (GO:0000046)2.40800891
181L-fucose catabolic process (GO:0042355)2.40179260
182fucose catabolic process (GO:0019317)2.40179260
183L-fucose metabolic process (GO:0042354)2.40179260
184establishment or maintenance of monopolar cell polarity (GO:0061339)2.39881004
185establishment of monopolar cell polarity (GO:0061162)2.39881004
186vitamin transport (GO:0051180)2.39222754
187nonribosomal peptide biosynthetic process (GO:0019184)2.38560550
188retinol metabolic process (GO:0042572)2.37212403
189histone H4-K12 acetylation (GO:0043983)2.36215579
190axonemal dynein complex assembly (GO:0070286)10.2471892

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.30353248
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.30353248
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.30353248
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.88548664
5ESR1_20079471_ChIP-ChIP_T-47D_Human4.29791166
6CDX2_20551321_ChIP-Seq_CACO-2_Human4.28423813
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.97507459
8ESR1_21235772_ChIP-Seq_MCF-7_Human3.71083543
9IKZF1_21737484_ChIP-ChIP_HCT116_Human3.64250787
10ESR2_21235772_ChIP-Seq_MCF-7_Human3.53655750
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.30515260
12TP63_17297297_ChIP-ChIP_HaCaT_Human3.25083281
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.16608936
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.94882288
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.81328450
16SRY_22984422_ChIP-ChIP_TESTIS_Rat2.45456345
17TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.39882457
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.34784971
19* RUNX1_27514584_Chip-Seq_MCF-7_Human2.34184552
20AHR_22903824_ChIP-Seq_MCF-7_Human2.27251569
21CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.22704481
22DROSHA_22980978_ChIP-Seq_HELA_Human2.17632243
23FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.15351036
24KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.05858520
25TCF3_18692474_ChIP-Seq_MEFs_Mouse2.00500696
26TDRD3_21172665_ChIP-Seq_MCF-7_Human1.98901230
27NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.93497240
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.90387645
29ESR1_15608294_ChIP-ChIP_MCF-7_Human1.89975683
30ARNT_22903824_ChIP-Seq_MCF-7_Human1.87399469
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.82748794
32SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.81569429
33ZNF217_24962896_ChIP-Seq_MCF-7_Human1.77585526
34* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.76464999
35NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.76229353
36IRF1_19129219_ChIP-ChIP_H3396_Human1.76130559
37VDR_22108803_ChIP-Seq_LS180_Human1.74161997
38CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.72417074
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.69142307
40CTCF_27219007_Chip-Seq_Bcells_Human1.68198787
41CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.67319029
42TCF3_18692474_ChIP-Seq_MESCs_Mouse1.66851009
43ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.65473500
44POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.62699542
45OCT4_18692474_ChIP-Seq_MEFs_Mouse1.61969597
46BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.61589308
47EZH2_22144423_ChIP-Seq_EOC_Human1.60636800
48LXR_22292898_ChIP-Seq_THP-1_Human1.59758490
49NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.58344147
50* GATA6_25053715_ChIP-Seq_YYC3_Human1.52229273
51CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.49853281
52RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48881348
53SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.45398247
54* GATA3_24758297_ChIP-Seq_MCF-7_Human1.41632863
55* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.40360457
56P68_20966046_ChIP-Seq_HELA_Human1.38596815
57KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.37382382
58E2F1_20622854_ChIP-Seq_HELA_Human1.36359764
59* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.31631874
60NANOG_18692474_ChIP-Seq_MEFs_Mouse1.31515648
61FOXM1_26456572_ChIP-Seq_MCF-7_Human1.31144947
62ERA_21632823_ChIP-Seq_H3396_Human1.30702269
63RACK7_27058665_Chip-Seq_MCF-7_Human1.30605467
64AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.29245052
65FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.29226816
66BCL6_27268052_Chip-Seq_Bcells_Human1.28365964
67* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.27799696
68* TP63_22573176_ChIP-Seq_HFKS_Human1.27539981
69FOXA1_25552417_ChIP-Seq_VCAP_Human1.26465479
70P63_26484246_Chip-Seq_KERATINOCYTES_Human1.26347456
71BCOR_27268052_Chip-Seq_Bcells_Human1.25262489
72ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.24705194
73FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.24418649
74* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.24178727
75POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.21426332
76IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.19512440
77TP53_20018659_ChIP-ChIP_R1E_Mouse1.19008307
78NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.18897187
79RING1B_27294783_Chip-Seq_NPCs_Mouse1.18798914
80KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17457327
81TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.16989725
82RNF2_27304074_Chip-Seq_ESCs_Mouse1.16476897
83POU5F1_16518401_ChIP-PET_MESCs_Mouse1.16238404
84TRIM28_21343339_ChIP-Seq_HEK293_Human1.15012172
85MYC_19079543_ChIP-ChIP_MESCs_Mouse1.14814094
86ELK1_22589737_ChIP-Seq_MCF10A_Human1.14146279
87STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.13979438
88ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.13965992
89RNF2_27304074_Chip-Seq_NSC_Mouse1.13567372
90CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11942082
91RAD21_21589869_ChIP-Seq_MESCs_Mouse1.11869641
92YY1_21170310_ChIP-Seq_MESCs_Mouse1.11390609
93HIF1A_21447827_ChIP-Seq_MCF-7_Human1.11152027
94P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.10768107
95POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10681477
96NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.10241096
97SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.09633572
98SOX2_18692474_ChIP-Seq_MEFs_Mouse1.09208262
99TET1_21451524_ChIP-Seq_MESCs_Mouse1.08855846
100SOX2_21211035_ChIP-Seq_LN229_Human1.07923968
101ER_23166858_ChIP-Seq_MCF-7_Human1.07558770
102EED_16625203_ChIP-ChIP_MESCs_Mouse1.06158889
103P300_27268052_Chip-Seq_Bcells_Human1.05613381
104PHF8_20622854_ChIP-Seq_HELA_Human1.05555378
105ELF5_23300383_ChIP-Seq_T47D_Human1.05401942
106SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04957728
107SA1_27219007_Chip-Seq_Bcells_Human1.04237923
108VDR_21846776_ChIP-Seq_THP-1_Human1.03232263
109* ERG_21242973_ChIP-ChIP_JURKAT_Human1.03190249
110RNF2_18974828_ChIP-Seq_MESCs_Mouse1.02939186
111EZH2_18974828_ChIP-Seq_MESCs_Mouse1.02939186
112* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.02517853
113ZNF263_19887448_ChIP-Seq_K562_Human1.01988498
114TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.01913034
115CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01505383
116ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00084589
117MAF_26560356_Chip-Seq_TH2_Human0.99711580
118* SOX2_20726797_ChIP-Seq_SW620_Human0.99412815
119POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99292861
120KLF5_25053715_ChIP-Seq_YYC3_Human0.98890327
121EZH2_27304074_Chip-Seq_ESCs_Mouse0.98696106
122CREB1_26743006_Chip-Seq_LNCaP_Human0.98517824
123GATA1_19941826_ChIP-Seq_K562_Human0.98420910
124AR_20517297_ChIP-Seq_VCAP_Human0.98335815
125MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.98149425
126FOXO3_23340844_ChIP-Seq_DLD1_Human0.97929566
127JARID2_20075857_ChIP-Seq_MESCs_Mouse0.97500077
128STAT1_20625510_ChIP-Seq_HELA_Human0.96479082
129SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.94896382
130NANOG_18555785_ChIP-Seq_MESCs_Mouse0.94575344
131REST_21632747_ChIP-Seq_MESCs_Mouse0.94504603
132YY1_22570637_ChIP-Seq_MALME-3M_Human0.93237637
133SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.93111325
134NANOG_18692474_ChIP-Seq_MESCs_Mouse0.93020855
135NANOG_20526341_ChIP-Seq_ESCs_Human0.92675354
136CTCF_20526341_ChIP-Seq_ESCs_Human0.90918015
137JARID2_20064375_ChIP-Seq_MESCs_Mouse0.90767516
138TAF2_19829295_ChIP-Seq_ESCs_Human0.90505047
139* SA1_27219007_Chip-Seq_ERYTHROID_Human0.89698682
140OCT4_20526341_ChIP-Seq_ESCs_Human0.89628805
141EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88948728
142PIAS1_25552417_ChIP-Seq_VCAP_Human0.88598189
143KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.88461115
144CBX2_27304074_Chip-Seq_ESCs_Mouse0.88225847
145EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.87800034
146* GATA4_25053715_ChIP-Seq_YYC3_Human0.87452435
147ELF1_17652178_ChIP-ChIP_JURKAT_Human0.87449708
148RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.87212726
149E2F1_17053090_ChIP-ChIP_MCF-7_Human0.87136057
150GATA3_21867929_ChIP-Seq_CD8_Mouse0.87016662
151ZFP281_27345836_Chip-Seq_ESCs_Mouse0.86795799
152SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.86762533
153STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.86469234
154RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85979539
155EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.85741882
156FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.85660092
157CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.85571634
158RING1B_27294783_Chip-Seq_ESCs_Mouse0.84990725
159CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.84731857
160SMC4_20622854_ChIP-Seq_HELA_Human0.84198138
161SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.83965074
162KDM2B_26808549_Chip-Seq_K562_Human0.83355887
163PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.82864374
164SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.81916153
165HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.81690398
166ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.81477864
167ELK3_25401928_ChIP-Seq_HUVEC_Human0.79770452

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004264_abnormal_extraembryonic_tissu4.79536900
2MP0003315_abnormal_perineum_morphology4.05055093
3MP0003011_delayed_dark_adaptation3.86424843
4MP0008875_abnormal_xenobiotic_pharmacok3.34700771
5MP0006292_abnormal_olfactory_placode3.28064214
6MP0000566_synostosis3.11035799
7MP0002277_abnormal_respiratory_mucosa3.03437571
8MP0009379_abnormal_foot_pigmentation2.68831434
9MP0005394_taste/olfaction_phenotype2.57559635
10MP0005499_abnormal_olfactory_system2.57559635
11MP0000490_abnormal_crypts_of2.49123190
12MP0009780_abnormal_chondrocyte_physiolo2.41627810
13MP0003938_abnormal_ear_development2.33348615
14MP0003866_abnormal_defecation2.30302176
15MP0005377_hearing/vestibular/ear_phenot2.28893343
16MP0003878_abnormal_ear_physiology2.28893343
17MP0010678_abnormal_skin_adnexa2.26775956
18MP0000383_abnormal_hair_follicle2.26113167
19MP0003300_gastrointestinal_ulcer2.21360662
20MP0003283_abnormal_digestive_organ2.21280662
21MP0010155_abnormal_intestine_physiology2.21176415
22MP0005257_abnormal_intraocular_pressure2.16239191
23MP0000678_abnormal_parathyroid_gland2.13909868
24MP0000049_abnormal_middle_ear2.12032901
25MP0008004_abnormal_stomach_pH2.07825164
26MP0010234_abnormal_vibrissa_follicle2.01136509
27MP0001663_abnormal_digestive_system2.00017365
28MP0004043_abnormal_pH_regulation1.93763261
29MP0002254_reproductive_system_inflammat1.89438658
30MP0003787_abnormal_imprinting1.88094422
31MP0001346_abnormal_lacrimal_gland1.84551654
32MP0000427_abnormal_hair_cycle1.83912397
33MP0005381_digestive/alimentary_phenotyp1.83187078
34MP0000462_abnormal_digestive_system1.80714325
35MP0003122_maternal_imprinting1.78711686
36MP0000762_abnormal_tongue_morphology1.78234519
37MP0000477_abnormal_intestine_morphology1.75854001
38MP0010030_abnormal_orbit_morphology1.70848461
39MP0004885_abnormal_endolymph1.67299479
40MP0004147_increased_porphyrin_level1.66806693
41MP0000537_abnormal_urethra_morphology1.66091359
42MP0001873_stomach_inflammation1.64385500
43MP0006082_CNS_inflammation1.61295932
44MP0004858_abnormal_nervous_system1.59642920
45MP0004133_heterotaxia1.58870424
46MP0008872_abnormal_physiological_respon1.58865507
47MP0005075_abnormal_melanosome_morpholog1.55798483
48MP0008789_abnormal_olfactory_epithelium1.55674798
49MP0005646_abnormal_pituitary_gland1.55451510
50MP0003638_abnormal_response/metabolism_1.53495862
51MP0004381_abnormal_hair_follicle1.52342232
52MP0004957_abnormal_blastocyst_morpholog1.51936287
53MP0001664_abnormal_digestion1.51259450
54MP0001919_abnormal_reproductive_system1.49975225
55MP0002876_abnormal_thyroid_physiology1.49118490
56MP0002822_catalepsy1.48000873
57MP0005085_abnormal_gallbladder_physiolo1.41482953
58MP0003183_abnormal_peptide_metabolism1.38729179
59MP0001849_ear_inflammation1.37926907
60MP0002009_preneoplasia1.37598856
61MP0005310_abnormal_salivary_gland1.35172401
62MP0002653_abnormal_ependyma_morphology1.30429420
63MP0002098_abnormal_vibrissa_morphology1.26423398
64MP0000579_abnormal_nail_morphology1.26407224
65MP0000465_gastrointestinal_hemorrhage1.24468546
66MP0004782_abnormal_surfactant_physiolog1.24067775
67MP0005083_abnormal_biliary_tract1.22831648
68MP0003121_genomic_imprinting1.22814610
69MP0002249_abnormal_larynx_morphology1.21786383
70MP0002132_abnormal_respiratory_system1.20635099
71MP0002751_abnormal_autonomic_nervous1.20300769
72MP0000613_abnormal_salivary_gland1.19462956
73MP0003385_abnormal_body_wall1.19429052
74MP0002932_abnormal_joint_morphology1.15113932
75MP0003119_abnormal_digestive_system1.14358031
76MP0003890_abnormal_embryonic-extraembry1.14227395
77MP0009643_abnormal_urine_homeostasis1.13705859
78MP0001188_hyperpigmentation1.12447615
79MP0001485_abnormal_pinna_reflex1.12433250
80MP0010329_abnormal_lipoprotein_level1.08853967
81MP0002796_impaired_skin_barrier1.08215214
82MP0003880_abnormal_central_pattern1.06170219
83MP0005389_reproductive_system_phenotype1.05931696
84MP0003879_abnormal_hair_cell1.03839513
85MP0003755_abnormal_palate_morphology1.03621827
86MP0000377_abnormal_hair_follicle1.03516376
87MP0009250_abnormal_appendicular_skeleto1.02610587
88MP0001216_abnormal_epidermal_layer1.02185633
89MP0002736_abnormal_nociception_after1.00412991
90MP0001881_abnormal_mammary_gland0.98959447
91MP0009053_abnormal_anal_canal0.98445173
92MP0001968_abnormal_touch/_nociception0.98326271
93MP0001765_abnormal_ion_homeostasis0.98103350
94MP0000627_abnormal_mammary_gland0.96055090
95MP0005365_abnormal_bile_salt0.95740244
96MP0002139_abnormal_hepatobiliary_system0.94981084
97MP0006035_abnormal_mitochondrial_morpho0.94042489
98MP0005367_renal/urinary_system_phenotyp0.93984822
99MP0000516_abnormal_urinary_system0.93984822
100MP0000432_abnormal_head_morphology0.93583478
101MP0002160_abnormal_reproductive_system0.93357458
102MP0002233_abnormal_nose_morphology0.93283697
103MP0004270_analgesia0.91829538
104MP0002735_abnormal_chemical_nociception0.90057586
105MP0000631_abnormal_neuroendocrine_gland0.89879033
106MP0002734_abnormal_mechanical_nocicepti0.89655070
107MP0003937_abnormal_limbs/digits/tail_de0.89321866
108MP0000538_abnormal_urinary_bladder0.87766484
109MP0000026_abnormal_inner_ear0.86925420
110MP0001756_abnormal_urination0.86871430
111MP0000467_abnormal_esophagus_morphology0.85884770
112MP0010771_integument_phenotype0.84547431
113MP0004019_abnormal_vitamin_homeostasis0.81990769
114MP0000163_abnormal_cartilage_morphology0.81914801
115MP0005248_abnormal_Harderian_gland0.81080769
116MP0000858_altered_metastatic_potential0.80718326
117MP0009384_cardiac_valve_regurgitation0.79516206
118MP0005636_abnormal_mineral_homeostasis0.79403639
119MP0005409_darkened_coat_color0.79329055
120MP0005360_urolithiasis0.78990828
121MP0005645_abnormal_hypothalamus_physiol0.78599609
122MP0001905_abnormal_dopamine_level0.78243165
123MP0003718_maternal_effect0.77940058
124MP0002114_abnormal_axial_skeleton0.76008447
125MP0006276_abnormal_autonomic_nervous0.75544696
126MP0009333_abnormal_splenocyte_physiolog0.74887659
127MP0001270_distended_abdomen0.74742341
128MP0010386_abnormal_urinary_bladder0.74581684
129MP0002332_abnormal_exercise_endurance0.74543286
130MP0005551_abnormal_eye_electrophysiolog0.74480651
131MP0002116_abnormal_craniofacial_bone0.74319001
132MP0002909_abnormal_adrenal_gland0.74264849
133MP0001944_abnormal_pancreas_morphology0.73717915
134MP0003936_abnormal_reproductive_system0.73173209
135MP0002136_abnormal_kidney_physiology0.72038784
136MP0009745_abnormal_behavioral_response0.71063007
137MP0003935_abnormal_craniofacial_develop0.70583318
138MP0004742_abnormal_vestibular_system0.69804811
139MP0001286_abnormal_eye_development0.68771812
140MP0002557_abnormal_social/conspecific_i0.68600891
141MP0009931_abnormal_skin_appearance0.68456787
142MP0003763_abnormal_thymus_physiology0.68334075
143MP0003123_paternal_imprinting0.66724180
144MP0003693_abnormal_embryo_hatching0.65637412
145MP0000470_abnormal_stomach_morphology0.65256367
146MP0002092_abnormal_eye_morphology0.63755712
147MP0001666_abnormal_nutrient_absorption0.63607467
148MP0003137_abnormal_impulse_conducting0.63241077
149MP0005671_abnormal_response_to0.63015430
150MP0006072_abnormal_retinal_apoptosis0.62228368
151MP0000428_abnormal_craniofacial_morphol0.62100824
152MP0002127_abnormal_cardiovascular_syste0.60530286
153MP0005167_abnormal_blood-brain_barrier0.60488275
154MP0005501_abnormal_skin_physiology0.60032108

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.23351925
2Abnormal respiratory motile cilium morphology (HP:0005938)8.02753281
3Abnormal respiratory epithelium morphology (HP:0012253)8.02753281
4Abnormal ciliary motility (HP:0012262)7.68029459
5Abnormal respiratory motile cilium physiology (HP:0012261)7.59048453
6Absent/shortened dynein arms (HP:0200106)7.37144577
7Dynein arm defect of respiratory motile cilia (HP:0012255)7.37144577
8Rhinitis (HP:0012384)7.13318097
9Nasal polyposis (HP:0100582)6.43346635
10Chronic bronchitis (HP:0004469)5.77117783
11Bronchiectasis (HP:0002110)5.58539972
12Abnormality of the nasal mucosa (HP:0000433)5.49682667
13Bilateral microphthalmos (HP:0007633)5.27539922
14Chronic sinusitis (HP:0011109)4.98691203
15Chronic otitis media (HP:0000389)4.80530692
16Abnormal hemoglobin (HP:0011902)4.75987541
17Concave nail (HP:0001598)4.23720553
18Villous atrophy (HP:0011473)3.96813410
19Abnormality of small intestinal villus morphology (HP:0011472)3.96813410
20Bronchitis (HP:0012387)3.94462918
21Hepatoblastoma (HP:0002884)3.85773504
22Cheilitis (HP:0100825)3.85628342
23Abnormality of the phalanges of the hallux (HP:0010057)3.85254259
24Decreased circulating renin level (HP:0003351)3.67189426
25Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.60847468
26Reticulocytopenia (HP:0001896)3.59010022
27Aplasia/Hypoplasia of the sacrum (HP:0008517)3.57927043
28Infertility (HP:0000789)3.55982309
29Multiple enchondromatosis (HP:0005701)3.52035519
30Testicular atrophy (HP:0000029)3.22112150
31Trismus (HP:0000211)3.17978891
32Rib fusion (HP:0000902)3.11006777
33Recurrent sinusitis (HP:0011108)3.09771851
34Abnormality of the distal phalanx of the thumb (HP:0009617)2.97501962
35Macrocytic anemia (HP:0001972)2.96473968
36Pallor (HP:0000980)2.95384070
37Abnormality of glutamine family amino acid metabolism (HP:0010902)2.91314243
38Rhabdomyosarcoma (HP:0002859)2.90742290
39Congenital sensorineural hearing impairment (HP:0008527)2.86025891
40Pili torti (HP:0003777)2.84715436
41Ileus (HP:0002595)2.84559739
42Malnutrition (HP:0004395)2.83025557
43Neoplasm of striated muscle (HP:0009728)2.81165965
44Combined immunodeficiency (HP:0005387)2.75426162
45Curly hair (HP:0002212)2.74165345
46Large earlobe (HP:0009748)2.73211244
47Recurrent bronchitis (HP:0002837)2.68887697
48Recurrent otitis media (HP:0000403)2.65704869
49Symphalangism affecting the phalanges of the hand (HP:0009773)2.65227080
50Sensory axonal neuropathy (HP:0003390)2.58922109
51Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.56581750
52Hyperactive renin-angiotensin system (HP:0000841)2.53142657
53Shawl scrotum (HP:0000049)2.51139974
54Aplasia/hypoplasia of the humerus (HP:0006507)2.50133712
55Cleft eyelid (HP:0000625)2.48221692
56Abnormality of cells of the erythroid lineage (HP:0012130)2.46736439
57Hypotrichosis (HP:0001006)2.44480943
58Renal salt wasting (HP:0000127)2.42720559
59Hyperphosphaturia (HP:0003109)2.40177984
60True hermaphroditism (HP:0010459)2.38543402
61Abdominal distention (HP:0003270)2.37734029
62Partial duplication of thumb phalanx (HP:0009944)2.37506898
63Nephroblastoma (Wilms tumor) (HP:0002667)2.37394332
64Partial duplication of the phalanx of hand (HP:0009999)2.33866336
65Ridged nail (HP:0001807)2.28933256
66Pancreatic cysts (HP:0001737)2.28795380
67Nephronophthisis (HP:0000090)2.28480231
68Hypochromic microcytic anemia (HP:0004840)2.27241356
69Fragile nails (HP:0001808)2.23341019
70Anomalous pulmonary venous return (HP:0010772)2.22879787
71Abnormality of nail color (HP:0100643)2.21773351
72Woolly hair (HP:0002224)2.21198197
73Alkalosis (HP:0001948)2.20925346
74Cystic liver disease (HP:0006706)2.20466965
75Reduced antithrombin III activity (HP:0001976)2.20215226
76Micronodular cirrhosis (HP:0001413)2.20129872
77Male infertility (HP:0003251)2.19957643
78Abnormal cartilage morphology (HP:0002763)2.18892930
79Abnormal hair laboratory examination (HP:0003328)2.18763370
80Amelogenesis imperfecta (HP:0000705)2.18743605
81Molar tooth sign on MRI (HP:0002419)2.18044333
82Abnormality of midbrain morphology (HP:0002418)2.18044333
83Metabolic alkalosis (HP:0200114)2.16765601
84Congenital ichthyosiform erythroderma (HP:0007431)2.16433411
85Embryonal renal neoplasm (HP:0011794)2.13294781
86Abnormality of carpal bone ossification (HP:0006257)2.12316177
87Hyperaldosteronism (HP:0000859)2.10102297
88Periauricular skin pits (HP:0100277)2.09924185
89Preauricular pit (HP:0004467)2.09924185
90Generalized hypotonia (HP:0001290)2.09534205
91Angiofibromas (HP:0010615)2.08737964
92Adenoma sebaceum (HP:0009720)2.08737964
93Pancreatic fibrosis (HP:0100732)2.08241436
94Short humerus (HP:0005792)2.06802277
95Abnormal number of erythroid precursors (HP:0012131)2.06581033
96Ragged-red muscle fibers (HP:0003200)2.04379829
97Aplasia/hypoplasia of the uterus (HP:0008684)2.04344474
98Renal Fanconi syndrome (HP:0001994)2.04325967
99Occipital encephalocele (HP:0002085)2.02410311
100Slow-growing hair (HP:0002217)2.01530098
101Abnormality of hair growth rate (HP:0011363)2.01530098
102Abnormality of the renal medulla (HP:0100957)2.00449658
103Dyschromatopsia (HP:0007641)2.00304258
104Hypoplasia of the fovea (HP:0007750)1.99755902
105Aplasia/Hypoplasia of the fovea (HP:0008060)1.99755902
106Fused cervical vertebrae (HP:0002949)1.98234702
107Abnormality of the renal cortex (HP:0011035)1.98181618
108Abnormality of chloride homeostasis (HP:0011422)1.98001450
109Progressive external ophthalmoplegia (HP:0000590)1.96973517
110Mitochondrial inheritance (HP:0001427)1.94743632
111Flat capital femoral epiphysis (HP:0003370)1.93344616
112Abnormal urine phosphate concentration (HP:0012599)1.93305690
113Short middle phalanx of finger (HP:0005819)1.92288352
114Abnormality of the 1st metacarpal (HP:0010009)1.90584774
115Microretrognathia (HP:0000308)1.90543024
116Abnormality of the pulmonary veins (HP:0011718)1.90370003
117Progressive muscle weakness (HP:0003323)1.89815256
118Triphalangeal thumb (HP:0001199)1.89036548
119Mildly elevated creatine phosphokinase (HP:0008180)1.88341048
120Congenital, generalized hypertrichosis (HP:0004540)1.87644491
121Acute necrotizing encephalopathy (HP:0006965)1.85968343
122Seborrheic dermatitis (HP:0001051)1.85869806
123Abnormality of renin-angiotensin system (HP:0000847)1.85786723
124Right ventricular cardiomyopathy (HP:0011663)1.85162106
125Chromosomal breakage induced by crosslinking agents (HP:0003221)1.84428863
126Pustule (HP:0200039)1.82126467
127Nasolacrimal duct obstruction (HP:0000579)1.81213962
128Furrowed tongue (HP:0000221)1.80496607
129Ventricular fibrillation (HP:0001663)1.79392685
130Lip pit (HP:0100267)1.79344095
131Chronic mucocutaneous candidiasis (HP:0002728)1.78733436
132Recurrent cutaneous fungal infections (HP:0011370)1.78733436
133Abnormality of proline metabolism (HP:0010907)1.78631286
134Hydroxyprolinuria (HP:0003080)1.78631286
135Chronic hepatic failure (HP:0100626)1.77474631
136High anterior hairline (HP:0009890)1.77199264
137Hyperkalemia (HP:0002153)1.76044995
138Type I transferrin isoform profile (HP:0003642)1.74662739
139Tubulointerstitial nephritis (HP:0001970)1.74510394
140Abdominal situs inversus (HP:0003363)1.74217153
141Abnormality of abdominal situs (HP:0011620)1.74217153
142Widely patent fontanelles and sutures (HP:0004492)1.73469278
143Inflammation of the large intestine (HP:0002037)1.72692589
144Porencephaly (HP:0002132)1.69886850
145Tubular atrophy (HP:0000092)1.69109934
146Enlarged epiphyses (HP:0010580)1.69065588
147Meckel diverticulum (HP:0002245)1.68718130
148Hyperparathyroidism (HP:0000843)1.68259855
149Syncope (HP:0001279)1.67695760
150Elevated erythrocyte sedimentation rate (HP:0003565)1.67631546
151Amblyopia (HP:0000646)1.67406506
152Abnormal lung lobation (HP:0002101)1.67116363
153Hepatocellular necrosis (HP:0001404)1.65275554
154Hyperventilation (HP:0002883)1.65158477
155Increased hepatocellular lipid droplets (HP:0006565)1.64510857
156Supernumerary ribs (HP:0005815)1.64401912
157Male pseudohermaphroditism (HP:0000037)1.62592145
158Short femoral neck (HP:0100864)1.58350671
159Acanthocytosis (HP:0001927)1.58075800
160Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.56776927
161Clumsiness (HP:0002312)1.55952185
162Decreased central vision (HP:0007663)1.53302594
163Medial flaring of the eyebrow (HP:0010747)1.53116963
164Abnormality of permanent molar morphology (HP:0011071)1.50385589
165Abnormality of the dental root (HP:0006486)1.50385589
166Taurodontia (HP:0000679)1.50385589
167Abnormal rod and cone electroretinograms (HP:0008323)1.49634576
168Abnormality of the proximal phalanges of the hand (HP:0009834)1.49542468
169Congenital stationary night blindness (HP:0007642)1.49398806
170Hypothermia (HP:0002045)1.48101819
171Cone-rod dystrophy (HP:0000548)1.47729844
172Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.46899345
173Growth hormone excess (HP:0000845)1.46833936
174Congenital hepatic fibrosis (HP:0002612)1.46556953
175Alveolar cell carcinoma (HP:0006519)1.46160011
176Hypokalemic alkalosis (HP:0001949)1.46036388
177Abnormality of secondary sexual hair (HP:0009888)1.45800579
178Abnormality of the axillary hair (HP:0100134)1.45800579
179Sparse lateral eyebrow (HP:0005338)1.45517908
180Stomach cancer (HP:0012126)1.44988930
181Genu varum (HP:0002970)1.44610306
182Abnormality of the frontal sinuses (HP:0002687)1.43738763
183Hyponatremia (HP:0002902)1.43705838
184Alopecia of scalp (HP:0002293)1.42789047
185Limb dystonia (HP:0002451)1.42212299
186Chronic diarrhea (HP:0002028)1.40067899
187Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.38156992
188Nephropathy (HP:0000112)1.37478826
189Metabolic acidosis (HP:0001942)1.37265977
190Abnormality of renal excretion (HP:0011036)1.37215058

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK16.21428940
2MAPK155.53957035
3CDK124.27231699
4MAPKAPK34.05132035
5GRK63.85747401
6ERN13.23549715
7GRK53.10386758
8TRIB32.88976358
9NME12.66616014
10GRK12.59378296
11MAP2K22.46566765
12MST42.44967753
13EPHB22.34835993
14PRKG22.32022717
15MAP3K132.24065023
16MUSK2.13437058
17NME22.06700423
18TYRO32.03017933
19SIK11.92703370
20TAOK31.90107063
21MATK1.89613044
22ADRBK21.87743110
23TGFBR21.82241642
24CASK1.80547876
25GRK71.79622944
26RPS6KB21.73109541
27STK101.63878948
28PRKD21.62361789
29AKT31.62014792
30ACVR1B1.59249095
31PKN21.58808498
32FRK1.55260003
33PIK3CA1.51847327
34MST1R1.51674449
35BLK1.50539666
36TNIK1.46046974
37LMTK21.42433900
38MKNK21.39927312
39ILK1.36495507
40MAP3K101.24685527
41CSK1.21972881
42CSF1R1.21884594
43TTK1.18844779
44EEF2K1.17053780
45ADRBK11.14046266
46MAPKAPK51.12072941
47PRKCI1.11462434
48WNK11.10311692
49EPHA31.09556525
50TESK21.04602663
51STK380.99725302
52TAF10.98949287
53MAP4K20.98682859
54MAPK130.97782060
55TAOK10.97253000
56PTK60.92479034
57CHUK0.92360389
58BMPR1B0.92172656
59BRAF0.90285361
60TNK20.88655979
61MAP3K120.88261639
62PHKG20.88137201
63PHKG10.88137201
64SRPK10.88099450
65MAP2K60.85228302
66MAP3K70.82135609
67DAPK30.81696132
68IRAK10.80870116
69FER0.80652857
70MAP2K40.80243095
71PAK40.79650284
72MAPK70.78495400
73CAMK40.77970099
74ITK0.75328912
75DDR20.73287662
76IKBKB0.71105789
77STK38L0.70617252
78MYLK0.70411638
79MAP2K10.69428134
80STK240.68871374
81NLK0.66704115
82OXSR10.66209709
83NUAK10.65608945
84MARK20.64342528
85MOS0.64024721
86PRKCZ0.63723474
87YES10.63307343
88HIPK20.62871360
89LRRK20.62712654
90NEK60.62441492
91IKBKE0.61598529
92CDK70.59601310
93NTRK20.58273624
94MAP2K70.57630931
95ERBB20.57220383
96MAP3K20.56549900
97CDK190.56017960
98RIPK40.55380467
99SMG10.55377709
100MARK10.54984797
101MAP3K110.54789840
102CHEK20.52843212
103STK110.50549940
104SIK20.50312953
105CDK90.48334591
106AURKB0.47598680
107MAP3K90.47467251
108AKT20.47352390
109PNCK0.46112196
110WNK40.45852378
111EPHA20.44914333
112CAMKK10.43037611
113DYRK1B0.42829695
114TESK10.40566675
115TBK10.40126213
116VRK20.39916720
117TAOK20.39532035
118IRAK20.39046189
119DYRK20.38312524
120PAK10.38147152
121PLK10.37862308
122PDPK10.37563226
123EPHB10.37334924
124FGR0.37281162
125RPS6KA20.35665211
126PINK10.35158184
127MAP4K10.35021123
128CDK11A0.34946080
129PRKCD0.34455661
130MAPK40.34149302
131BMPR20.33606523
132CAMK2B0.32975236
133INSRR0.32805627
134IRAK40.30145051
135BTK0.28699179
136CDK150.28538075
137CDK30.27773225
138STK390.27473442
139CDC42BPA0.27199475
140LCK0.27043354
141SGK10.26666848
142PTK20.26465863
143SGK20.26094808
144CDK180.25952216
145PRKCQ0.25529579
146RIPK10.25357033
147IRAK30.24656075
148CSNK1E0.24080435
149MAP3K40.23320404
150RET0.23139994
151MAP3K30.22742581
152UHMK10.22672265
153MAP3K60.22666446
154PRKCA0.22527024
155SGK2230.22291599
156SGK4940.22291599
157CAMK2G0.21791337
158PRKACA0.21184864
159EPHA40.20799074
160MAPK120.20366935
161FGFR30.20327973
162ZAP700.20147915
163TXK0.19462696

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.75146360
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.58101774
3Oxidative phosphorylation_Homo sapiens_hsa001902.87273791
4Chemical carcinogenesis_Homo sapiens_hsa052042.80221481
5Vitamin digestion and absorption_Homo sapiens_hsa049772.73256381
6Caffeine metabolism_Homo sapiens_hsa002322.71537984
7Sulfur metabolism_Homo sapiens_hsa009202.61908886
8Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.49172619
9Arachidonic acid metabolism_Homo sapiens_hsa005902.31549073
10Fructose and mannose metabolism_Homo sapiens_hsa000512.28366392
11Parkinsons disease_Homo sapiens_hsa050122.21788154
12Sulfur relay system_Homo sapiens_hsa041222.10050113
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.06251380
14Phenylalanine metabolism_Homo sapiens_hsa003602.01586224
15Mineral absorption_Homo sapiens_hsa049781.99439787
16Tyrosine metabolism_Homo sapiens_hsa003501.98432764
17Alzheimers disease_Homo sapiens_hsa050101.93599633
18Galactose metabolism_Homo sapiens_hsa000521.87157821
19Linoleic acid metabolism_Homo sapiens_hsa005911.86897873
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.78110119
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.73407051
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.71520370
23Retinol metabolism_Homo sapiens_hsa008301.69021636
24Fat digestion and absorption_Homo sapiens_hsa049751.68639085
25Thyroid cancer_Homo sapiens_hsa052161.57089667
26Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.56378523
27Huntingtons disease_Homo sapiens_hsa050161.56218225
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.50288490
29Primary immunodeficiency_Homo sapiens_hsa053401.49095302
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.47406080
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.46003589
32Other glycan degradation_Homo sapiens_hsa005111.42555357
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.41274092
34Collecting duct acid secretion_Homo sapiens_hsa049661.36331548
35Carbohydrate digestion and absorption_Homo sapiens_hsa049731.34809546
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.33786417
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.30395575
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.29912138
39Cocaine addiction_Homo sapiens_hsa050301.29873230
40Bladder cancer_Homo sapiens_hsa052191.25725147
41Cardiac muscle contraction_Homo sapiens_hsa042601.25194118
42ABC transporters_Homo sapiens_hsa020101.23803054
43Phototransduction_Homo sapiens_hsa047441.20687156
44Amphetamine addiction_Homo sapiens_hsa050311.18676158
45Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.13259754
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.12585451
47Nicotine addiction_Homo sapiens_hsa050331.10659419
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.08264013
49Fatty acid elongation_Homo sapiens_hsa000621.08175636
50Homologous recombination_Homo sapiens_hsa034401.01292528
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.00389280
52Ether lipid metabolism_Homo sapiens_hsa005650.98022725
53Renin-angiotensin system_Homo sapiens_hsa046140.97771113
54Asthma_Homo sapiens_hsa053100.97368063
55Tight junction_Homo sapiens_hsa045300.95856537
56beta-Alanine metabolism_Homo sapiens_hsa004100.95111898
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.94865337
58Nitrogen metabolism_Homo sapiens_hsa009100.93687482
59T cell receptor signaling pathway_Homo sapiens_hsa046600.88319074
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.87921598
61Glycerophospholipid metabolism_Homo sapiens_hsa005640.87603712
62VEGF signaling pathway_Homo sapiens_hsa043700.85499903
63Basal cell carcinoma_Homo sapiens_hsa052170.82621574
64Starch and sucrose metabolism_Homo sapiens_hsa005000.81468754
65Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.81384149
66Choline metabolism in cancer_Homo sapiens_hsa052310.79336351
67Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.78978544
68Protein digestion and absorption_Homo sapiens_hsa049740.78442189
69Fatty acid degradation_Homo sapiens_hsa000710.74130456
70Bile secretion_Homo sapiens_hsa049760.73755389
71Taste transduction_Homo sapiens_hsa047420.73270682
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.73082577
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72933748
74Glycerolipid metabolism_Homo sapiens_hsa005610.72397492
75Regulation of autophagy_Homo sapiens_hsa041400.71605513
76Hepatitis C_Homo sapiens_hsa051600.71586568
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.71209681
78* Sphingolipid metabolism_Homo sapiens_hsa006000.70731766
79Peroxisome_Homo sapiens_hsa041460.69101794
80Ovarian steroidogenesis_Homo sapiens_hsa049130.68015738
81Fatty acid biosynthesis_Homo sapiens_hsa000610.67326719
82Tryptophan metabolism_Homo sapiens_hsa003800.67086300
83Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66197059
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.64429794
85Vitamin B6 metabolism_Homo sapiens_hsa007500.63710733
86PPAR signaling pathway_Homo sapiens_hsa033200.63237534
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62296259
88Acute myeloid leukemia_Homo sapiens_hsa052210.61520041
89Renin secretion_Homo sapiens_hsa049240.60233472
90Salivary secretion_Homo sapiens_hsa049700.60108885
91GnRH signaling pathway_Homo sapiens_hsa049120.59899318
92Allograft rejection_Homo sapiens_hsa053300.59403858
93Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59272887
94Long-term depression_Homo sapiens_hsa047300.57444745
95Insulin secretion_Homo sapiens_hsa049110.55315224
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.55023060
97Autoimmune thyroid disease_Homo sapiens_hsa053200.54942543
98DNA replication_Homo sapiens_hsa030300.54626884
99African trypanosomiasis_Homo sapiens_hsa051430.52068697
100Hematopoietic cell lineage_Homo sapiens_hsa046400.52014175
101Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51930733
102Folate biosynthesis_Homo sapiens_hsa007900.51396097
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.49524387
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49253620
105Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48894292
106Cyanoamino acid metabolism_Homo sapiens_hsa004600.48450311
107Fanconi anemia pathway_Homo sapiens_hsa034600.48347295
108Leishmaniasis_Homo sapiens_hsa051400.47585045
109Wnt signaling pathway_Homo sapiens_hsa043100.47539825
110Rap1 signaling pathway_Homo sapiens_hsa040150.46586974
111Spliceosome_Homo sapiens_hsa030400.44486369
112Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44005981
113Melanogenesis_Homo sapiens_hsa049160.44000035
114Salmonella infection_Homo sapiens_hsa051320.43690424
115Dopaminergic synapse_Homo sapiens_hsa047280.42706816
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41466893
117RNA polymerase_Homo sapiens_hsa030200.41062040
118Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40900241
119Histidine metabolism_Homo sapiens_hsa003400.39851924
120Arginine biosynthesis_Homo sapiens_hsa002200.38968120
121Endometrial cancer_Homo sapiens_hsa052130.38816205
122Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36921448
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36330894
124Inositol phosphate metabolism_Homo sapiens_hsa005620.36003026
125Ras signaling pathway_Homo sapiens_hsa040140.35613961
126Adherens junction_Homo sapiens_hsa045200.34846220
127cAMP signaling pathway_Homo sapiens_hsa040240.34163441
128Type I diabetes mellitus_Homo sapiens_hsa049400.34034921
129Pathways in cancer_Homo sapiens_hsa052000.33924726
130Pancreatic secretion_Homo sapiens_hsa049720.33616602
131Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33430824
132Estrogen signaling pathway_Homo sapiens_hsa049150.33377958
133Insulin resistance_Homo sapiens_hsa049310.32957869
134Serotonergic synapse_Homo sapiens_hsa047260.32775253
135Antigen processing and presentation_Homo sapiens_hsa046120.32361329
136Cholinergic synapse_Homo sapiens_hsa047250.32127536
137Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32062811
138Pertussis_Homo sapiens_hsa051330.31875440
139Herpes simplex infection_Homo sapiens_hsa051680.31463596
140Graft-versus-host disease_Homo sapiens_hsa053320.31448772
141Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.30629187
142Circadian entrainment_Homo sapiens_hsa047130.30464861
143Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.29615384
144Prolactin signaling pathway_Homo sapiens_hsa049170.29347338
145Calcium signaling pathway_Homo sapiens_hsa040200.28807360
146Glutathione metabolism_Homo sapiens_hsa004800.28768123
147Hedgehog signaling pathway_Homo sapiens_hsa043400.28716819
148Glutamatergic synapse_Homo sapiens_hsa047240.28620188
149B cell receptor signaling pathway_Homo sapiens_hsa046620.28578381
150Tuberculosis_Homo sapiens_hsa051520.27126907
151Vascular smooth muscle contraction_Homo sapiens_hsa042700.26875820
152Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25987077
153ErbB signaling pathway_Homo sapiens_hsa040120.25781056
154Prostate cancer_Homo sapiens_hsa052150.25680984
155Influenza A_Homo sapiens_hsa051640.25225663
156Pyrimidine metabolism_Homo sapiens_hsa002400.24156447
157Axon guidance_Homo sapiens_hsa043600.23667886

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