DENND1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by organism of defense response of other organism involved in symbiotic interact5.08386769
2modulation by symbiont of host immune response (GO:0052553)5.08386769
3positive regulation by symbiont of host defense response (GO:0052509)5.08386769
4modulation by symbiont of host defense response (GO:0052031)5.08386769
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.08386769
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.08386769
7positive regulation of cellular amide metabolic process (GO:0034250)4.66875948
8pyrimidine nucleobase catabolic process (GO:0006208)4.54999073
9protein polyglutamylation (GO:0018095)4.37332085
10olfactory bulb development (GO:0021772)4.18166499
11somite development (GO:0061053)4.14486782
12retinal ganglion cell axon guidance (GO:0031290)4.06651467
13epithelial cilium movement (GO:0003351)4.06391873
14negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.76826419
15negative regulation of astrocyte differentiation (GO:0048712)3.75774525
16response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.72435646
17response to host immune response (GO:0052572)3.72435646
18dendritic spine morphogenesis (GO:0060997)3.66657233
19regulation of interferon-beta biosynthetic process (GO:0045357)3.64408078
20cilium movement (GO:0003341)3.59588245
21histone H3-K9 methylation (GO:0051567)3.56722217
22epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.54205826
23neutrophil activation involved in immune response (GO:0002283)3.53889256
24macrophage activation involved in immune response (GO:0002281)3.53844506
25histone H3-K9 modification (GO:0061647)3.53198506
26thalamus development (GO:0021794)3.53063987
27nucleobase catabolic process (GO:0046113)3.47441647
28intraciliary transport (GO:0042073)3.42888781
29cell proliferation in forebrain (GO:0021846)3.42058092
30postsynaptic membrane organization (GO:0001941)3.40024722
31positive regulation of oligodendrocyte differentiation (GO:0048714)3.34560101
32response to host (GO:0075136)3.34175659
33response to host defenses (GO:0052200)3.34175659
34response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.34175659
35axon ensheathment in central nervous system (GO:0032291)3.31207775
36central nervous system myelination (GO:0022010)3.31207775
37antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.30891742
38cilium or flagellum-dependent cell motility (GO:0001539)3.29806780
39I-kappaB phosphorylation (GO:0007252)3.29576164
40neuronal stem cell maintenance (GO:0097150)3.22279796
41natural killer cell mediated immunity (GO:0002228)3.22067594
42natural killer cell mediated cytotoxicity (GO:0042267)3.22067594
43histone H3-K4 trimethylation (GO:0080182)3.21965059
44negative regulation of DNA-templated transcription, elongation (GO:0032785)3.16932452
45positive regulation of interferon-alpha production (GO:0032727)3.16482401
46axon extension involved in axon guidance (GO:0048846)3.11024108
47neuron projection extension involved in neuron projection guidance (GO:1902284)3.11024108
48adult walking behavior (GO:0007628)3.09594107
49microglial cell activation (GO:0001774)3.09294197
50regulation of interferon-alpha production (GO:0032647)3.09288286
51limb bud formation (GO:0060174)3.08467526
52positive regulation of neuroblast proliferation (GO:0002052)3.05176312
53negative regulation of cell killing (GO:0031342)3.04063747
54negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.04063747
55response to peptidoglycan (GO:0032494)3.04034638
56axoneme assembly (GO:0035082)3.03981763
57response to muramyl dipeptide (GO:0032495)3.01317981
58positive regulation of gamma-delta T cell activation (GO:0046645)2.98038604
59killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.97217091
60disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.97217091
61DNA integration (GO:0015074)2.97211215
62neuronal ion channel clustering (GO:0045161)2.97190417
63centriole replication (GO:0007099)2.95976913
64modulation by symbiont of host cellular process (GO:0044068)2.90813328
65opioid receptor signaling pathway (GO:0038003)2.89404769
66phosphatidylglycerol biosynthetic process (GO:0006655)2.87382594
67cell wall macromolecule catabolic process (GO:0016998)2.87013309
68negative regulation of granulocyte differentiation (GO:0030853)2.86982109
69neuroblast proliferation (GO:0007405)2.85814008
70L-amino acid import (GO:0043092)2.85658051
71positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.85632467
72glial cell proliferation (GO:0014009)2.83985030
73myeloid cell activation involved in immune response (GO:0002275)2.82607235
74neutrophil mediated immunity (GO:0002446)2.81370635
75auditory receptor cell differentiation (GO:0042491)2.81351550
76neurotransmitter catabolic process (GO:0042135)2.80251443
77eosinophil chemotaxis (GO:0048245)2.79876669
78positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.79276932
79positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.78607515
80mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.78607515
81transmission of nerve impulse (GO:0019226)2.77762554
82cell wall macromolecule metabolic process (GO:0044036)2.76201183
83layer formation in cerebral cortex (GO:0021819)2.76004527
84macrophage activation (GO:0042116)2.73246998
85cellular response to cholesterol (GO:0071397)2.72871710
86cerebral cortex radially oriented cell migration (GO:0021799)2.72558819
87positive regulation of CREB transcription factor activity (GO:0032793)2.71304629
88monocyte chemotaxis (GO:0002548)2.70645362
89histone H4 deacetylation (GO:0070933)2.70606732
90regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.69646957
91regulation of mononuclear cell migration (GO:0071675)2.68267310
92leukocyte migration involved in inflammatory response (GO:0002523)2.67935512
93negative regulation of translation, ncRNA-mediated (GO:0040033)2.65687677
94regulation of translation, ncRNA-mediated (GO:0045974)2.65687677
95negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.65687677
96regulation of interleukin-12 biosynthetic process (GO:0045075)2.65485235
97negative regulation of glial cell differentiation (GO:0045686)2.65250838
98presynaptic membrane organization (GO:0097090)2.65196013
99germinal center formation (GO:0002467)2.64183574
100cilium assembly (GO:0042384)2.62439594
101granulocyte activation (GO:0036230)2.62091598
102positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.61726157
103negative regulation of oligodendrocyte differentiation (GO:0048715)2.61470385
104retinal rod cell development (GO:0046548)2.60761838
105smoothened signaling pathway (GO:0007224)2.59664844
106regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.59595151
107response to misfolded protein (GO:0051788)2.59586911
108negative regulation of axon guidance (GO:1902668)2.59060964
109neural precursor cell proliferation (GO:0061351)2.58712120
110neuron fate determination (GO:0048664)2.58064411
111negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.55984981
112central nervous system projection neuron axonogenesis (GO:0021952)2.55925640
113startle response (GO:0001964)2.55878323
114cellular response to ethanol (GO:0071361)2.54913029
115protein K11-linked deubiquitination (GO:0035871)2.54383071
116cilium organization (GO:0044782)2.53560980
117cerebral cortex neuron differentiation (GO:0021895)2.53041570
118neutrophil activation (GO:0042119)2.52594991
119regulation of collateral sprouting (GO:0048670)2.50733373
120ventricular system development (GO:0021591)2.50575663
121positive regulation of mast cell activation involved in immune response (GO:0033008)2.50200598
122positive regulation of mast cell degranulation (GO:0043306)2.50200598
123regulation of mast cell degranulation (GO:0043304)2.49172959
124G-protein coupled receptor internalization (GO:0002031)2.48242178
125regulation of timing of cell differentiation (GO:0048505)2.47869471
126immunoglobulin mediated immune response (GO:0016064)2.47696570
127regulation of neurotransmitter uptake (GO:0051580)2.46958357
128response to pheromone (GO:0019236)2.46261705
129establishment of mitochondrion localization (GO:0051654)2.45659709
130positive regulation of amino acid transport (GO:0051957)2.45487475
131astrocyte differentiation (GO:0048708)2.45441758
132lipopolysaccharide-mediated signaling pathway (GO:0031663)2.44975686
133axonal fasciculation (GO:0007413)2.44150574
134cellular response to type I interferon (GO:0071357)2.44097989
135type I interferon signaling pathway (GO:0060337)2.44097989
136negative regulation of lipid storage (GO:0010888)2.43502001
137response to type I interferon (GO:0034340)2.43192539
138regulation of oligodendrocyte differentiation (GO:0048713)2.42946635
139positive regulation of p38MAPK cascade (GO:1900745)2.42752477
140pinocytosis (GO:0006907)2.42741101
141modulation by virus of host process (GO:0019054)2.42307575
142negative thymic T cell selection (GO:0045060)2.41340378
143base-excision repair, AP site formation (GO:0006285)2.41284552
144nonmotile primary cilium assembly (GO:0035058)2.40986289
145cilium morphogenesis (GO:0060271)2.40443404
146negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.40431043
147presynaptic membrane assembly (GO:0097105)2.40248365
148cell adhesion mediated by integrin (GO:0033627)2.39915702
149regulation of B cell receptor signaling pathway (GO:0050855)2.38762836
150regulation of cellular amide metabolic process (GO:0034248)2.37481652
151regulation of mast cell activation involved in immune response (GO:0033006)2.36964567
152regulation of beta-amyloid formation (GO:1902003)2.36105057
153regulation of germinal center formation (GO:0002634)2.36025859
154positive regulation of heat generation (GO:0031652)2.35129503
155detection of molecule of bacterial origin (GO:0032490)2.34471927
156regulation of clathrin-mediated endocytosis (GO:2000369)2.33596211
157eosinophil migration (GO:0072677)2.33242966
158macroautophagy (GO:0016236)2.30288390
159regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.30042269
160positive regulation of mast cell activation (GO:0033005)2.29167234
161regulation of myeloid leukocyte mediated immunity (GO:0002886)2.28057866
162positive regulation of antigen processing and presentation (GO:0002579)2.26641401
163regulation of leukocyte degranulation (GO:0043300)2.25568454
164* synaptic vesicle endocytosis (GO:0048488)2.23474392
165alanine transport (GO:0032328)2.23367926
166regulation of ARF protein signal transduction (GO:0032012)2.22368129
167lymphocyte chemotaxis (GO:0048247)2.19876217
168positive regulation of interleukin-1 beta secretion (GO:0050718)2.19642167
169leukocyte mediated cytotoxicity (GO:0001909)2.19111424
170myeloid leukocyte mediated immunity (GO:0002444)2.17186034
171interferon-gamma-mediated signaling pathway (GO:0060333)2.15782210
172phospholipid homeostasis (GO:0055091)2.15687848
173clathrin coat assembly (GO:0048268)2.10123061
174T cell migration (GO:0072678)2.09897267
175positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.08974588
176B cell homeostasis (GO:0001782)2.08444396
177regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.08294648
178negative regulation of interleukin-17 production (GO:0032700)2.08292563
179ionotropic glutamate receptor signaling pathway (GO:0035235)2.07221701
180synaptic vesicle maturation (GO:0016188)2.07124219
181locomotory exploration behavior (GO:0035641)2.07074717
182positive regulation of interferon-beta production (GO:0032728)2.06950332
183modification by symbiont of host morphology or physiology (GO:0044003)2.06272401
184regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.05589477
185lens fiber cell differentiation (GO:0070306)2.05239673
186positive regulation of Rac GTPase activity (GO:0032855)2.04595678
187response to interferon-alpha (GO:0035455)2.04540667
188amino acid import (GO:0043090)2.03798473

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.49317626
2ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.45844233
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.34142926
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.27460374
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.08441344
6STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.64623205
7Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.63515552
8GBX2_23144817_ChIP-Seq_PC3_Human2.58730611
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.58114286
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.53373981
11CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.44425008
12VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.43666778
13* IRF8_27001747_Chip-Seq_BMDM_Mouse2.43222400
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.40370193
15IRF1_19129219_ChIP-ChIP_H3396_Human2.31325481
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.16067709
17MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.15709138
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.03651788
19CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.98131109
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96234453
21VDR_21846776_ChIP-Seq_THP-1_Human1.96189357
22DROSHA_22980978_ChIP-Seq_HELA_Human1.95785923
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.92819418
24ZNF274_21170338_ChIP-Seq_K562_Hela1.92478436
25NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.89698639
26SMAD_19615063_ChIP-ChIP_OVARY_Human1.75230094
27CIITA_25753668_ChIP-Seq_RAJI_Human1.68375078
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.61648774
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.61409083
30* SPI1_23127762_ChIP-Seq_K562_Human1.61384335
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59332361
32BCL6_27268052_Chip-Seq_Bcells_Human1.58757874
33VDR_24787735_ChIP-Seq_THP-1_Human1.53333792
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.50966584
35EZH2_22144423_ChIP-Seq_EOC_Human1.50573666
36SCL_19346495_ChIP-Seq_HPC-7_Human1.49962132
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48981555
38* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.46404430
39BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.44451424
40ZNF217_24962896_ChIP-Seq_MCF-7_Human1.43741843
41EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.43543998
42* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.42556135
43* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.36712506
44SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.36703091
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.36437925
46PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36433662
47CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.36298178
48TP63_19390658_ChIP-ChIP_HaCaT_Human1.35603329
49GATA2_21666600_ChIP-Seq_HMVEC_Human1.34571471
50CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32645257
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.32230367
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31897622
53ELF1_20517297_ChIP-Seq_JURKAT_Human1.30968538
54SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.30428638
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30416332
56OCT4_19829295_ChIP-Seq_ESCs_Human1.30184339
57RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.29587006
58SUZ12_27294783_Chip-Seq_ESCs_Mouse1.29422461
59RUNX_20019798_ChIP-Seq_JUKART_Human1.29152710
60NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.28400203
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26152688
62CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.24843279
63TAF15_26573619_Chip-Seq_HEK293_Human1.24597790
64P68_20966046_ChIP-Seq_HELA_Human1.24324685
65SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.21746791
66TP53_16413492_ChIP-PET_HCT116_Human1.20722128
67IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.20072013
68ETV2_25802403_ChIP-Seq_MESCs_Mouse1.19691601
69AHR_22903824_ChIP-Seq_MCF-7_Human1.19441995
70* SMC4_20622854_ChIP-Seq_HELA_Human1.19291480
71DNAJC2_21179169_ChIP-ChIP_NT2_Human1.19186415
72PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17637575
73CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17626586
74SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.17140381
75SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.16468109
76ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16433363
77* SMAD4_21799915_ChIP-Seq_A2780_Human1.16022743
78* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15749241
79ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.15150748
80SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.14252510
81* STAT3_23295773_ChIP-Seq_U87_Human1.13175453
82SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.12627688
83IGF1R_20145208_ChIP-Seq_DFB_Human1.12577570
84MTF2_20144788_ChIP-Seq_MESCs_Mouse1.12413335
85BCOR_27268052_Chip-Seq_Bcells_Human1.11884319
86* WDR5_24793694_ChIP-Seq_LNCAP_Human1.11780837
87RARB_27405468_Chip-Seq_BRAIN_Mouse1.09993992
88EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09962786
89MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09678664
90GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.08878248
91SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.08437968
92OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.08087395
93ARNT_22903824_ChIP-Seq_MCF-7_Human1.07765414
94SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.07458373
95RXR_22108803_ChIP-Seq_LS180_Human1.07102338
96NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.07080258
97* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06720963
98E2F1_17053090_ChIP-ChIP_MCF-7_Human1.04599234
99SOX3_22085726_ChIP-Seq_NPCs_Mouse1.04277736
100PIAS1_25552417_ChIP-Seq_VCAP_Human1.03477179
101PHF8_20622854_ChIP-Seq_HELA_Human1.02499270
102TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01391855
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00280675
104POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00280675
105BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00218994
106TCF4_23295773_ChIP-Seq_U87_Human0.99231469
107SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.99128011
108RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98910033
109REST_21632747_ChIP-Seq_MESCs_Mouse0.98622916
110RNF2_18974828_ChIP-Seq_MESCs_Mouse0.98512235
111EZH2_18974828_ChIP-Seq_MESCs_Mouse0.98512235
112* GATA1_19941827_ChIP-Seq_MEL_Mouse0.98244442
113MYC_19829295_ChIP-Seq_ESCs_Human0.97972834
114MYB_21317192_ChIP-Seq_ERMYB_Mouse0.97652810
115PU_27001747_Chip-Seq_BMDM_Mouse0.96582637
116HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.96493129
117ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96064789
118MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.95513727
119JARID2_20064375_ChIP-Seq_MESCs_Mouse0.94988019
120* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94685072
121LXR_22292898_ChIP-Seq_THP-1_Human0.94047482
122GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93804593
123SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.93640441
124AR_21572438_ChIP-Seq_LNCaP_Human0.93558640
125KDM2B_26808549_Chip-Seq_SUP-B15_Human0.93299271
126* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.92242606
127P300_19829295_ChIP-Seq_ESCs_Human0.92131016
128GATA1_26923725_Chip-Seq_HPCs_Mouse0.92083920
129NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.92010245
130* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91566649
131E2F1_20622854_ChIP-Seq_HELA_Human0.91414236
132TAF2_19829295_ChIP-Seq_ESCs_Human0.90784500
133SMAD3_21741376_ChIP-Seq_EPCs_Human0.90442546
134TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.90283040
135NANOG_21062744_ChIP-ChIP_HESCs_Human0.90177410
136RAC3_21632823_ChIP-Seq_H3396_Human0.90006167
137YY1_22570637_ChIP-Seq_MALME-3M_Human0.89800668
138SMAD3_21741376_ChIP-Seq_HESCs_Human0.89751618
139RNF2_27304074_Chip-Seq_ESCs_Mouse0.89746315
140* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89726985
141EGR1_19032775_ChIP-ChIP_M12_Human0.89726228
142* E2F1_18555785_Chip-Seq_ESCs_Mouse0.89640317
143CTNNB1_20460455_ChIP-Seq_HCT116_Human0.89515195
144AR_25329375_ChIP-Seq_VCAP_Human0.89447684
145EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.88867288
146* NANOG_18555785_Chip-Seq_ESCs_Mouse0.88484807
147RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.88217699
148ZFP57_27257070_Chip-Seq_ESCs_Mouse0.87877793
149ERA_21632823_ChIP-Seq_H3396_Human0.86425771
150EZH2_27294783_Chip-Seq_ESCs_Mouse0.85936883
151P53_22127205_ChIP-Seq_FIBROBLAST_Human0.85785756
152* AR_19668381_ChIP-Seq_PC3_Human0.85759374
153VDR_24763502_ChIP-Seq_THP-1_Human0.85360084
154* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85135699
155EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.84764727
156* FOXA2_19822575_ChIP-Seq_HepG2_Human0.84681911
157SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.84415898
158RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.83982105
159* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.83570575
160GATA1_19941826_ChIP-Seq_K562_Human0.83432011
161* SOX2_21211035_ChIP-Seq_LN229_Gbm0.82800234
162VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.82465145
163YY1_21170310_ChIP-Seq_MESCs_Mouse0.82371411
164NR3C1_21868756_ChIP-Seq_MCF10A_Human0.81896762
165NR3C1_23031785_ChIP-Seq_PC12_Mouse0.81730655
166SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.80212336
167* SOX9_26525672_Chip-Seq_HEART_Mouse0.79606859
168PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.79191437
169PKCTHETA_26484144_Chip-Seq_BREAST_Human0.79131212
170YAP1_20516196_ChIP-Seq_MESCs_Mouse0.79109884
171KDM2B_26808549_Chip-Seq_K562_Human0.79090984
172KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.78654254
173MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.78220072
174SOX2_18555785_ChIP-Seq_MESCs_Mouse0.78170528
175SOX2_16153702_ChIP-ChIP_HESCs_Human0.78087419

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.90862348
2MP0002653_abnormal_ependyma_morphology4.13257965
3MP0004510_myositis3.65393385
4MP0006292_abnormal_olfactory_placode3.53979578
5MP0003172_abnormal_lysosome_physiology3.45923452
6MP0003880_abnormal_central_pattern3.43117069
7MP0005058_abnormal_lysosome_morphology2.95664118
8MP0001835_abnormal_antigen_presentation2.86646685
9MP0005377_hearing/vestibular/ear_phenot2.86540458
10MP0003878_abnormal_ear_physiology2.86540458
11MP0004859_abnormal_synaptic_plasticity2.71123876
12MP0003122_maternal_imprinting2.47520269
13MP0000778_abnormal_nervous_system2.43373072
14MP0005174_abnormal_tail_pigmentation2.41254558
15MP0000015_abnormal_ear_pigmentation2.34558079
16MP0005394_taste/olfaction_phenotype2.31781516
17MP0005499_abnormal_olfactory_system2.31781516
18MP0003303_peritoneal_inflammation2.31403271
19MP0002419_abnormal_innate_immunity2.26028404
20MP0005387_immune_system_phenotype2.25981476
21MP0001790_abnormal_immune_system2.25981476
22MP0003690_abnormal_glial_cell2.25612729
23MP0002102_abnormal_ear_morphology2.17168719
24MP0008789_abnormal_olfactory_epithelium2.09623486
25MP0005248_abnormal_Harderian_gland2.09442421
26MP0006082_CNS_inflammation2.07887327
27MP0009278_abnormal_bone_marrow2.06639967
28MP0005423_abnormal_somatic_nervous2.01162669
29MP0003436_decreased_susceptibility_to1.96588992
30MP0003075_altered_response_to1.91997524
31MP0002148_abnormal_hypersensitivity_rea1.86213563
32MP0001529_abnormal_vocalization1.84132865
33MP0004742_abnormal_vestibular_system1.83356721
34MP0004147_increased_porphyrin_level1.82661461
35MP0002249_abnormal_larynx_morphology1.81231326
36MP0005000_abnormal_immune_tolerance1.75412559
37MP0003938_abnormal_ear_development1.74477590
38MP0001293_anophthalmia1.73929330
39MP0005076_abnormal_cell_differentiation1.72639128
40MP0003300_gastrointestinal_ulcer1.69027324
41MP0005167_abnormal_blood-brain_barrier1.68468886
42MP0005310_abnormal_salivary_gland1.62425336
43MP0009046_muscle_twitch1.61090746
44MP0005551_abnormal_eye_electrophysiolog1.60620136
45MP0002452_abnormal_antigen_presenting1.59772984
46MP0003136_yellow_coat_color1.58247185
47MP0005253_abnormal_eye_physiology1.56125534
48MP0000371_diluted_coat_color1.55370741
49MP0010030_abnormal_orbit_morphology1.55074594
50MP0001800_abnormal_humoral_immune1.54996300
51MP0002234_abnormal_pharynx_morphology1.54532770
52MP0002723_abnormal_immune_serum1.51379678
53MP0005025_abnormal_response_to1.51273054
54MP0008877_abnormal_DNA_methylation1.50597093
55MP0000566_synostosis1.48999686
56MP0003828_pulmonary_edema1.47459790
57MP0000604_amyloidosis1.44043081
58MP0000685_abnormal_immune_system1.43037391
59MP0000026_abnormal_inner_ear1.42839891
60MP0003121_genomic_imprinting1.42257225
61MP0001501_abnormal_sleep_pattern1.39705747
62MP0005464_abnormal_platelet_physiology1.37284529
63MP0003183_abnormal_peptide_metabolism1.36907598
64MP0002396_abnormal_hematopoietic_system1.35596880
65MP0009785_altered_susceptibility_to1.32366077
66MP0006072_abnormal_retinal_apoptosis1.32294395
67MP0002557_abnormal_social/conspecific_i1.31468520
68MP0002998_abnormal_bone_remodeling1.31438538
69MP0002166_altered_tumor_susceptibility1.30810374
70MP0001819_abnormal_immune_cell1.30660302
71MP0002282_abnormal_trachea_morphology1.30290768
72MP0005671_abnormal_response_to1.30128566
73MP0000955_abnormal_spinal_cord1.29651614
74MP0005670_abnormal_white_adipose1.29289671
75MP0005083_abnormal_biliary_tract1.28936972
76MP0003191_abnormal_cellular_cholesterol1.28407249
77MP0002420_abnormal_adaptive_immunity1.27776599
78MP0002064_seizures1.25995271
79MP0009764_decreased_sensitivity_to1.22629621
80MP0001963_abnormal_hearing_physiology1.22486823
81MP0003635_abnormal_synaptic_transmissio1.22325669
82MP0001485_abnormal_pinna_reflex1.22171861
83MP0009745_abnormal_behavioral_response1.22156762
84MP0002638_abnormal_pupillary_reflex1.20063349
85MP0005397_hematopoietic_system_phenotyp1.19433324
86MP0001545_abnormal_hematopoietic_system1.19433324
87MP0005391_vision/eye_phenotype1.19318078
88MP0002751_abnormal_autonomic_nervous1.17520232
89MP0003724_increased_susceptibility_to1.17028797
90MP0003283_abnormal_digestive_organ1.16596806
91MP0003787_abnormal_imprinting1.14182101
92MP0008260_abnormal_autophagy1.13338517
93MP0003950_abnormal_plasma_membrane1.13200684
94MP0002928_abnormal_bile_duct1.12760662
95MP0002152_abnormal_brain_morphology1.12602734
96MP0001533_abnormal_skeleton_physiology1.12568680
97MP0009780_abnormal_chondrocyte_physiolo1.10909699
98MP0005409_darkened_coat_color1.10573816
99MP0004142_abnormal_muscle_tone1.09280774
100MP0003045_fibrosis1.09243068
101MP0001968_abnormal_touch/_nociception1.08851470
102MP0002063_abnormal_learning/memory/cond1.07608674
103MP0001764_abnormal_homeostasis1.06698896
104MP0003633_abnormal_nervous_system1.06446268
105MP0002272_abnormal_nervous_system1.03339134
106MP0009840_abnormal_foam_cell1.02515931
107MP0000631_abnormal_neuroendocrine_gland1.02218415
108MP0002006_tumorigenesis1.00963132
109MP0002882_abnormal_neuron_morphology1.00958448
110MP0008961_abnormal_basal_metabolism1.00698142
111MP0002405_respiratory_system_inflammati1.00189351
112MP0010307_abnormal_tumor_latency0.99474452
113MP0002938_white_spotting0.99058644
114MP0006276_abnormal_autonomic_nervous0.99057544
115MP0004858_abnormal_nervous_system0.98526249
116MP0002090_abnormal_vision0.96275358
117MP0002092_abnormal_eye_morphology0.95968498
118MP0003698_abnormal_male_reproductive0.94149599
119MP0000343_altered_response_to0.93989105
120MP0002752_abnormal_somatic_nervous0.93036907
121MP0003861_abnormal_nervous_system0.92972581
122MP0005646_abnormal_pituitary_gland0.91254505
123MP0002572_abnormal_emotion/affect_behav0.90681977
124MP0005171_absent_coat_pigmentation0.90578349
125MP0003448_altered_tumor_morphology0.89270651
126MP0000049_abnormal_middle_ear0.88792416
127MP0005257_abnormal_intraocular_pressure0.88520965
128MP0003091_abnormal_cell_migration0.88483753
129MP0002734_abnormal_mechanical_nocicepti0.88330794
130MP0002332_abnormal_exercise_endurance0.86644367
131MP0001845_abnormal_inflammatory_respons0.86101139
132MP0004947_skin_inflammation0.85271542
133MP0005166_decreased_susceptibility_to0.84890732
134MP0008469_abnormal_protein_level0.84238987
135MP0001853_heart_inflammation0.83425573
136MP0001486_abnormal_startle_reflex0.82201902
137MP0003011_delayed_dark_adaptation0.82179399
138MP0004133_heterotaxia0.81759917
139MP0001324_abnormal_eye_pigmentation0.81201935
140MP0004270_analgesia0.80550479
141MP0002229_neurodegeneration0.80299163
142MP0001970_abnormal_pain_threshold0.78808520
143MP0005451_abnormal_body_composition0.78100442
144MP0003634_abnormal_glial_cell0.77962264
145MP0001984_abnormal_olfaction0.77511592
146MP0000383_abnormal_hair_follicle0.77202510
147MP0003631_nervous_system_phenotype0.77151935
148MP0004811_abnormal_neuron_physiology0.77143150
149MP0005195_abnormal_posterior_eye0.77019329
150MP0000716_abnormal_immune_system0.75976263
151MP0004130_abnormal_muscle_cell0.75796634
152MP0002168_other_aberrant_phenotype0.75749921
153MP0001929_abnormal_gametogenesis0.75332180
154MP0002398_abnormal_bone_marrow0.73237814
155MP0008569_lethality_at_weaning0.73089293
156MP0002075_abnormal_coat/hair_pigmentati0.72714816
157MP0001986_abnormal_taste_sensitivity0.72582415
158MP0002067_abnormal_sensory_capabilities0.70532955
159MP0005075_abnormal_melanosome_morpholog0.70112205
160MP0002138_abnormal_hepatobiliary_system0.69853921
161MP0003329_amyloid_beta_deposits0.69360686
162MP0002733_abnormal_thermal_nociception0.69106827
163MP0002735_abnormal_chemical_nociception0.68979096
164MP0004924_abnormal_behavior0.68970736
165MP0005386_behavior/neurological_phenoty0.68970736
166MP0002736_abnormal_nociception_after0.68552414
167MP0002822_catalepsy0.67790720
168MP0002066_abnormal_motor_capabilities/c0.66991115
169MP0005410_abnormal_fertilization0.66701766
170MP0003632_abnormal_nervous_system0.66053954
171MP0008058_abnormal_DNA_repair0.65641472
172MP0003879_abnormal_hair_cell0.63561375
173MP0001440_abnormal_grooming_behavior0.63102644
174MP0009763_increased_sensitivity_to0.62729505
175MP0000689_abnormal_spleen_morphology0.62442690
176MP0005535_abnormal_body_temperature0.62425684
177MP0001958_emphysema0.62262286
178MP0005645_abnormal_hypothalamus_physiol0.61540085

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.78769513
2Recurrent bacterial skin infections (HP:0005406)4.60654684
3True hermaphroditism (HP:0010459)3.81612699
4Increased cerebral lipofuscin (HP:0011813)3.45570422
5Pancreatic fibrosis (HP:0100732)3.39485669
6Eczematoid dermatitis (HP:0000976)3.39353244
7High anterior hairline (HP:0009890)3.33760271
8Autoimmune thrombocytopenia (HP:0001973)3.26330122
9Gingivitis (HP:0000230)3.18411012
10Cystic liver disease (HP:0006706)3.05884516
11Abnormality of the fingertips (HP:0001211)3.00589712
12Prostate neoplasm (HP:0100787)2.93965589
13Pancreatic cysts (HP:0001737)2.93587425
14Increased neuronal autofluorescent lipopigment (HP:0002074)2.92957317
15Hyperglycinemia (HP:0002154)2.92644748
16Chronic hepatic failure (HP:0100626)2.92010461
17Recurrent gram-negative bacterial infections (HP:0005420)2.89784667
18Retrobulbar optic neuritis (HP:0100654)2.87883241
19Optic neuritis (HP:0100653)2.87883241
20Submucous cleft hard palate (HP:0000176)2.84906417
21Abnormal biliary tract physiology (HP:0012439)2.83635394
22Bile duct proliferation (HP:0001408)2.83635394
23Nephronophthisis (HP:0000090)2.80270175
24Mediastinal lymphadenopathy (HP:0100721)2.79546287
25Tented upper lip vermilion (HP:0010804)2.78426748
26Abnormality of macrophages (HP:0004311)2.77350416
27Periodontitis (HP:0000704)2.76029027
28Myokymia (HP:0002411)2.73842543
29Postaxial foot polydactyly (HP:0001830)2.73626940
30Myositis (HP:0100614)2.71620328
31Orchitis (HP:0100796)2.69118822
32Abnormality of glycolipid metabolism (HP:0010969)2.68899065
33Abnormality of liposaccharide metabolism (HP:0010968)2.68899065
34Abnormality of glycosphingolipid metabolism (HP:0004343)2.68899065
35Urethral obstruction (HP:0000796)2.66754944
36Abnormality of midbrain morphology (HP:0002418)2.66348850
37Molar tooth sign on MRI (HP:0002419)2.66348850
38Stomatitis (HP:0010280)2.64268598
39Abnormal gallbladder physiology (HP:0012438)2.61702563
40Cholecystitis (HP:0001082)2.61702563
41Recurrent skin infections (HP:0001581)2.61453816
42Systemic lupus erythematosus (HP:0002725)2.59973660
43Genetic anticipation (HP:0003743)2.59329632
44Tubulointerstitial nephritis (HP:0001970)2.58678097
45Hepatoblastoma (HP:0002884)2.58520684
46Hyperglycinuria (HP:0003108)2.57814527
47Febrile seizures (HP:0002373)2.53597578
48Axonal loss (HP:0003447)2.53127872
49Thick nail (HP:0001805)2.52524457
50Broad distal phalanx of finger (HP:0009836)2.52263955
51Abnormal ciliary motility (HP:0012262)2.48021963
52Medial flaring of the eyebrow (HP:0010747)2.46706543
53Supernumerary spleens (HP:0009799)2.44891978
54Abnormality of glycine metabolism (HP:0010895)2.44625008
55Abnormality of serine family amino acid metabolism (HP:0010894)2.44625008
56Anophthalmia (HP:0000528)2.43486216
57Bone pain (HP:0002653)2.42598840
58Oligodactyly (HP:0012165)2.38351653
59Abnormality of the aortic arch (HP:0012303)2.36893971
60Progressive visual loss (HP:0000529)2.36429308
61Vacuolated lymphocytes (HP:0001922)2.36092698
62Arterial thrombosis (HP:0004420)2.35596884
63Oligodactyly (hands) (HP:0001180)2.34594365
64Preaxial hand polydactyly (HP:0001177)2.33655818
65Gingival bleeding (HP:0000225)2.33530733
66Supranuclear gaze palsy (HP:0000605)2.31788019
67Impulsivity (HP:0100710)2.30662494
68Gait imbalance (HP:0002141)2.29018455
69Sclerocornea (HP:0000647)2.28119711
70Broad foot (HP:0001769)2.26950637
71Absent/shortened dynein arms (HP:0200106)2.26867992
72Dynein arm defect of respiratory motile cilia (HP:0012255)2.26867992
73Aplasia/Hypoplasia of the tongue (HP:0010295)2.26617588
74Congenital primary aphakia (HP:0007707)2.26586730
75Elevated erythrocyte sedimentation rate (HP:0003565)2.26429676
76Lower limb amyotrophy (HP:0007210)2.25594187
77Vitreoretinal degeneration (HP:0000655)2.23163300
78Recurrent fungal infections (HP:0002841)2.20843338
79Abnormality of the renal medulla (HP:0100957)2.20725174
80Hematochezia (HP:0002573)2.19017449
81Congenital hepatic fibrosis (HP:0002612)2.18982317
82Albinism (HP:0001022)2.18920143
83Slow saccadic eye movements (HP:0000514)2.17207786
84Chromosomal breakage induced by crosslinking agents (HP:0003221)2.16068719
85Distal lower limb amyotrophy (HP:0008944)2.15235910
86Postaxial hand polydactyly (HP:0001162)2.13998169
87Abnormality of polysaccharide metabolism (HP:0011012)2.13635835
88Abnormality of glycosaminoglycan metabolism (HP:0004371)2.13635835
89Abnormality of mucopolysaccharide metabolism (HP:0011020)2.13635835
90Optic nerve coloboma (HP:0000588)2.13031211
91Amblyopia (HP:0000646)2.13025395
92Colon cancer (HP:0003003)2.12311508
93Excessive salivation (HP:0003781)2.11701219
94Drooling (HP:0002307)2.11701219
95Hypochromic microcytic anemia (HP:0004840)2.10984744
96Macroorchidism (HP:0000053)2.10706747
97Premature loss of primary teeth (HP:0006323)2.09964577
98Pulmonary artery stenosis (HP:0004415)2.09672449
99Abnormality of DNA repair (HP:0003254)2.08563168
100Anencephaly (HP:0002323)2.08135483
101Partial agenesis of the corpus callosum (HP:0001338)2.07452607
102Disinhibition (HP:0000734)2.07402357
103Generalized hypopigmentation (HP:0007513)2.07396649
104Absent speech (HP:0001344)2.07350253
105Nephrogenic diabetes insipidus (HP:0009806)2.06197780
106Widely spaced teeth (HP:0000687)2.03584352
107Intestinal atresia (HP:0011100)2.03488866
108Polyphagia (HP:0002591)2.03258466
109Pulmonary infiltrates (HP:0002113)2.00827778
110Pathologic fracture (HP:0002756)2.00700091
111Tetany (HP:0001281)2.00568166
112Inappropriate behavior (HP:0000719)2.00050725
113Vasculitis (HP:0002633)1.99617682
114Focal seizures (HP:0007359)1.98436976
115Protruding tongue (HP:0010808)1.97818493
116Abnormal respiratory epithelium morphology (HP:0012253)1.97328846
117Abnormal respiratory motile cilium morphology (HP:0005938)1.97328846
118Narrow palate (HP:0000189)1.94679104
119Chromsome breakage (HP:0040012)1.94495652
120Annular pancreas (HP:0001734)1.94191969
121Ocular albinism (HP:0001107)1.94035573
122Absent frontal sinuses (HP:0002688)1.93070813
123Progressive cerebellar ataxia (HP:0002073)1.91174165
124Joint hemorrhage (HP:0005261)1.90962057
125Holoprosencephaly (HP:0001360)1.90458170
126Urinary bladder sphincter dysfunction (HP:0002839)1.89718878
127Neoplasm of the adrenal cortex (HP:0100641)1.89552408
128Occipital encephalocele (HP:0002085)1.89270872
129Anosmia (HP:0000458)1.86953320
130Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.86757827
131Attenuation of retinal blood vessels (HP:0007843)1.86494854
132Supernumerary ribs (HP:0005815)1.85719177
133Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.85015154
134Short 4th metacarpal (HP:0010044)1.85015154
135Broad finger (HP:0001500)1.84684689
136Dysostosis multiplex (HP:0000943)1.84281418
137Frequent falls (HP:0002359)1.83575369
138Amyloidosis (HP:0011034)1.83567054
139Poor coordination (HP:0002370)1.83473503
140Abnormality of the lower motor neuron (HP:0002366)1.83367811
141Generalized hypopigmentation of hair (HP:0011358)1.82345615
142Epileptic encephalopathy (HP:0200134)1.82106344
143Septo-optic dysplasia (HP:0100842)1.82072794
144Abnormality of the parathyroid morphology (HP:0011766)1.81067952
145Large earlobe (HP:0009748)1.80423463
146Morphological abnormality of the inner ear (HP:0011390)1.80417315
147Broad phalanges of the hand (HP:0009768)1.79972613
148Abnormality of the ileum (HP:0001549)1.79737008
149Broad thumb (HP:0011304)1.78864495
150Recurrent viral infections (HP:0004429)1.78851700
151Basal ganglia calcification (HP:0002135)1.78154265
152Recurrent cutaneous fungal infections (HP:0011370)1.77549774
153Chronic mucocutaneous candidiasis (HP:0002728)1.77549774
154Abnormality of binocular vision (HP:0011514)1.77535183
155Diplopia (HP:0000651)1.77535183
156Decreased central vision (HP:0007663)1.76861398
157Bruising susceptibility (HP:0000978)1.76478326
158Postural instability (HP:0002172)1.76262052
159Progressive microcephaly (HP:0000253)1.75570811
160Trigonocephaly (HP:0000243)1.75336535
161Abnormality of the nasal septum (HP:0000419)1.75254461
162Focal motor seizures (HP:0011153)1.74994572
163Supernumerary bones of the axial skeleton (HP:0009144)1.74217325
164Mucopolysacchariduria (HP:0008155)1.73705734
165Urinary glycosaminoglycan excretion (HP:0003541)1.73705734
166Growth hormone deficiency (HP:0000824)1.73576583
167Deformed sella turcica (HP:0002681)1.73479194
168Fair hair (HP:0002286)1.73296422
169Optic nerve hypoplasia (HP:0000609)1.72801620
170Abnormal respiratory motile cilium physiology (HP:0012261)1.70600695
171Abnormality of salivation (HP:0100755)1.70546204
172Hypoplasia of the thymus (HP:0000778)1.70493186
173Abnormal eating behavior (HP:0100738)1.70310521
174Obstructive lung disease (HP:0006536)1.69914141
175Chronic obstructive pulmonary disease (HP:0006510)1.69914141
176Specific learning disability (HP:0001328)1.68532281
177Spinal muscular atrophy (HP:0007269)1.68108309
178Abnormality of the columella (HP:0009929)1.67557020
179Aplasia/Hypoplasia of the spleen (HP:0010451)1.66696521
180Myocardial infarction (HP:0001658)1.65434812
181Abnormal number of incisors (HP:0011064)1.65429989
182Ectopic kidney (HP:0000086)1.64376249
183Broad phalanx (HP:0006009)1.63588930
184Glomerulonephritis (HP:0000099)1.62101952
185Neuronal loss in central nervous system (HP:0002529)1.62022067
186Iris coloboma (HP:0000612)1.61968048
187Iris hypopigmentation (HP:0007730)1.58796300
188Chin dimple (HP:0010751)1.58385086
189Tubulointerstitial abnormality (HP:0001969)1.57870205
190Hemiparesis (HP:0001269)1.57642138
191Absent rod-and cone-mediated responses on ERG (HP:0007688)1.57117169
192Microvesicular hepatic steatosis (HP:0001414)1.57037199
193Abnormality of glycolysis (HP:0004366)1.56672006
194Oculomotor apraxia (HP:0000657)1.55987021
195Tubular atrophy (HP:0000092)1.55609254

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK3.98994001
2MAP4K23.45482718
3CDK193.28105766
4MAP3K143.09803859
5RIPK42.99080589
6TNK22.62790172
7SIK22.61607818
8IRAK32.42400457
9CAMK1G2.30694616
10TESK22.16911242
11MAP3K132.16678344
12IKBKE2.16023542
13MAP3K112.12750257
14CAMK1D2.11336736
15TAOK32.09204728
16SGK22.04747199
17SIK32.04228538
18KIT2.03895640
19DAPK22.02670860
20JAK11.94890156
21SGK31.92132898
22TYK21.87240565
23CDK121.83472112
24NTRK31.76606443
25IRAK41.75157358
26EPHA31.67511830
27BLK1.66660804
28MAPK151.58030083
29UHMK11.55004420
30EPHA41.54456128
31NTRK21.50611363
32EPHB11.38747708
33DYRK1B1.38293513
34JAK31.36626679
35CHUK1.34699534
36TBK11.34426752
37FRK1.34253862
38EPHB21.31713724
39TIE11.30732303
40BMPR21.30353473
41SGK2231.28989206
42SGK4941.28989206
43IKBKB1.28988992
44MAPK131.27437559
45FES1.24625578
46CSNK1G31.21263829
47PINK11.21196306
48CCNB11.19790881
49CSNK1A1L1.19307317
50SGK11.18048444
51STK381.17769220
52TXK1.17028240
53WNK31.15831661
54DYRK21.09483879
55CSNK1G21.08011135
56ZAK1.06693232
57HCK1.05922271
58PLK41.05178521
59GRK61.04647245
60MAP2K41.00105281
61SIK10.99462264
62KSR10.95837955
63INSRR0.95604213
64RIPK10.95225516
65BRD40.92434717
66DYRK30.92281570
67PRKCH0.92195097
68MAP4K10.92188409
69PRPF4B0.91742712
70NEK90.89713607
71ADRBK20.89124792
72STK110.87954728
73WNK10.87921404
74TAOK10.85805755
75CSNK1G10.84367992
76IRAK20.83464647
77FGFR30.80574060
78SYK0.77710594
79CASK0.77080558
80CAMK40.76201520
81ERN10.74993271
82PTK60.74317774
83HIPK20.73814530
84PAK60.73792885
85MAP2K70.73392590
86PTK2B0.72690137
87TNIK0.71998150
88PKN10.71403132
89BMPR1B0.71079197
90PRKD30.70141824
91CSK0.69476010
92ERBB30.69366724
93MAP3K40.68830410
94TRIM280.66959417
95BMX0.66901370
96BRSK10.66836376
97JAK20.66036894
98VRK20.61843175
99MAPK70.61513813
100CDK60.60105829
101STK40.59261502
102PLK20.59074591
103DMPK0.58884183
104NTRK10.58491265
105CLK10.58390026
106MKNK10.57139807
107MARK30.56873040
108VRK10.56534752
109OXSR10.56441141
110ATR0.56299862
111NEK20.55510291
112CDK50.55100218
113MINK10.54140002
114DAPK10.53482632
115MAPK100.53182590
116ABL10.52008124
117PRKCZ0.51759791
118MAP3K70.50919163
119EGFR0.50577801
120LCK0.50546564
121CDK11A0.50167487
122PNCK0.49965846
123CAMK10.49642825
124CAMKK10.49498341
125CSF1R0.48490834
126TTN0.48417557
127LYN0.47965832
128MARK20.47469488
129MAPK120.46520964
130MARK10.46123271
131FYN0.45731267
132PDPK10.45513453
133PRKAA20.44955146
134FGR0.44952503
135YES10.43827962
136PAK30.43800948
137PRKCG0.43646588
138ARAF0.43326913
139CDK150.43260502
140TYRO30.42657217
141ERBB20.41514293
142FGFR20.41200556
143PDK10.41177456
144TEC0.41011882
145BTK0.40521746
146DYRK1A0.39989451
147MAPK80.39946559
148RPS6KA60.39886758
149EIF2AK20.39670900
150CHEK20.38920374
151MAP2K30.38913777
152PRKCE0.38534929
153IRAK10.38314222
154CDK180.38002535
155BCR0.36538754
156CDK140.36463829

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.77383349
2Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.89303817
3Propanoate metabolism_Homo sapiens_hsa006402.73122841
4Fanconi anemia pathway_Homo sapiens_hsa034602.65718518
5Base excision repair_Homo sapiens_hsa034102.64239118
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.42047644
7Butanoate metabolism_Homo sapiens_hsa006502.40112816
8Hedgehog signaling pathway_Homo sapiens_hsa043402.19079769
9Basal cell carcinoma_Homo sapiens_hsa052172.15384508
10Steroid biosynthesis_Homo sapiens_hsa001002.14984474
11Homologous recombination_Homo sapiens_hsa034402.02462894
12Nitrogen metabolism_Homo sapiens_hsa009101.96519030
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.90708264
14Staphylococcus aureus infection_Homo sapiens_hsa051501.83245726
15Osteoclast differentiation_Homo sapiens_hsa043801.82399812
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.82330132
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.79059131
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.70180542
19Type II diabetes mellitus_Homo sapiens_hsa049301.68285203
20Leishmaniasis_Homo sapiens_hsa051401.67593786
21Tuberculosis_Homo sapiens_hsa051521.58408678
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.47927110
23Olfactory transduction_Homo sapiens_hsa047401.46745813
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.45465336
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.42859919
26Lysosome_Homo sapiens_hsa041421.38190227
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.37817019
28Synaptic vesicle cycle_Homo sapiens_hsa047211.36394365
29Rheumatoid arthritis_Homo sapiens_hsa053231.36187168
30Influenza A_Homo sapiens_hsa051641.35198290
31Morphine addiction_Homo sapiens_hsa050321.35120874
32B cell receptor signaling pathway_Homo sapiens_hsa046621.34776324
33Peroxisome_Homo sapiens_hsa041461.31277352
34Measles_Homo sapiens_hsa051621.30659457
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.29661168
36Chemokine signaling pathway_Homo sapiens_hsa040621.29200000
37Regulation of autophagy_Homo sapiens_hsa041401.28903508
38Fatty acid metabolism_Homo sapiens_hsa012121.28044540
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.27978696
40Nicotine addiction_Homo sapiens_hsa050331.26854598
41Cocaine addiction_Homo sapiens_hsa050301.24953321
42Non-homologous end-joining_Homo sapiens_hsa034501.24642911
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.22239534
44Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.21867957
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.21727514
46Axon guidance_Homo sapiens_hsa043601.21497592
47RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.19921134
48Lysine degradation_Homo sapiens_hsa003101.19618563
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17764373
50Malaria_Homo sapiens_hsa051441.15791258
51Sulfur relay system_Homo sapiens_hsa041221.13248920
52Pertussis_Homo sapiens_hsa051331.12984859
53TNF signaling pathway_Homo sapiens_hsa046681.11622348
54Glutamatergic synapse_Homo sapiens_hsa047241.11473598
55Circadian entrainment_Homo sapiens_hsa047131.10047394
56Intestinal immune network for IgA production_Homo sapiens_hsa046721.09546021
57Dorso-ventral axis formation_Homo sapiens_hsa043201.06620483
58Toxoplasmosis_Homo sapiens_hsa051451.05947936
59Chronic myeloid leukemia_Homo sapiens_hsa052201.04567222
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.02238736
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.01215131
62Collecting duct acid secretion_Homo sapiens_hsa049661.00968764
63Glioma_Homo sapiens_hsa052140.97973449
64Fructose and mannose metabolism_Homo sapiens_hsa000510.96080953
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.95919282
66Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.95508217
67Inositol phosphate metabolism_Homo sapiens_hsa005620.93320327
68GABAergic synapse_Homo sapiens_hsa047270.91610689
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88332669
70Salivary secretion_Homo sapiens_hsa049700.88275003
71African trypanosomiasis_Homo sapiens_hsa051430.88009755
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87840428
73Ether lipid metabolism_Homo sapiens_hsa005650.87279459
74Carbon metabolism_Homo sapiens_hsa012000.86898102
75Insulin secretion_Homo sapiens_hsa049110.86460577
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.86038193
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84338603
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84272242
79Cholinergic synapse_Homo sapiens_hsa047250.84054583
80Other glycan degradation_Homo sapiens_hsa005110.83322920
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83104154
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.81501273
83Pancreatic cancer_Homo sapiens_hsa052120.81409400
84Long-term potentiation_Homo sapiens_hsa047200.81271683
85Allograft rejection_Homo sapiens_hsa053300.81011951
86Calcium signaling pathway_Homo sapiens_hsa040200.80669897
87Biosynthesis of amino acids_Homo sapiens_hsa012300.80155968
88Arginine and proline metabolism_Homo sapiens_hsa003300.79840014
89Hepatitis C_Homo sapiens_hsa051600.79505034
90Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.79319047
91Choline metabolism in cancer_Homo sapiens_hsa052310.78967849
92Hepatitis B_Homo sapiens_hsa051610.78755721
93Gastric acid secretion_Homo sapiens_hsa049710.78684757
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78670938
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78663737
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.77876686
97cAMP signaling pathway_Homo sapiens_hsa040240.77668357
98Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.77505586
99Phagosome_Homo sapiens_hsa041450.77159871
100Herpes simplex infection_Homo sapiens_hsa051680.77019209
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76882545
102ErbB signaling pathway_Homo sapiens_hsa040120.76740823
103Dilated cardiomyopathy_Homo sapiens_hsa054140.75873602
104Renin secretion_Homo sapiens_hsa049240.75373969
105Tryptophan metabolism_Homo sapiens_hsa003800.72274744
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70269713
107Acute myeloid leukemia_Homo sapiens_hsa052210.70241572
108Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70073253
109Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70027985
110Prolactin signaling pathway_Homo sapiens_hsa049170.69834358
111ABC transporters_Homo sapiens_hsa020100.69794646
112Jak-STAT signaling pathway_Homo sapiens_hsa046300.69668769
113Oxytocin signaling pathway_Homo sapiens_hsa049210.69584127
114Asthma_Homo sapiens_hsa053100.69323313
115Apoptosis_Homo sapiens_hsa042100.68978768
116Caffeine metabolism_Homo sapiens_hsa002320.68189914
117Salmonella infection_Homo sapiens_hsa051320.67098620
118Cyanoamino acid metabolism_Homo sapiens_hsa004600.66634275
119MAPK signaling pathway_Homo sapiens_hsa040100.66375402
120T cell receptor signaling pathway_Homo sapiens_hsa046600.65037657
121Notch signaling pathway_Homo sapiens_hsa043300.64599563
122GnRH signaling pathway_Homo sapiens_hsa049120.64539953
123Glycerolipid metabolism_Homo sapiens_hsa005610.64194365
124Linoleic acid metabolism_Homo sapiens_hsa005910.64109401
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64003527
126Non-small cell lung cancer_Homo sapiens_hsa052230.63942648
127Taste transduction_Homo sapiens_hsa047420.63812215
128Thyroid hormone synthesis_Homo sapiens_hsa049180.63318430
129Insulin resistance_Homo sapiens_hsa049310.61690288
130Phototransduction_Homo sapiens_hsa047440.61045388
131Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60556685
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.60005084
133Amphetamine addiction_Homo sapiens_hsa050310.59639100
134Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59466220
135Viral myocarditis_Homo sapiens_hsa054160.59380672
136beta-Alanine metabolism_Homo sapiens_hsa004100.58215439
137Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58168725
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.57958277
139Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57588261
140Dopaminergic synapse_Homo sapiens_hsa047280.57083608
141Hematopoietic cell lineage_Homo sapiens_hsa046400.56933110
142mTOR signaling pathway_Homo sapiens_hsa041500.56855476
143Bile secretion_Homo sapiens_hsa049760.56576738
144Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56522225
145Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55353747
146Fat digestion and absorption_Homo sapiens_hsa049750.53439226
147Melanogenesis_Homo sapiens_hsa049160.53242153
148Alcoholism_Homo sapiens_hsa050340.51430743
149Arachidonic acid metabolism_Homo sapiens_hsa005900.47845472
150DNA replication_Homo sapiens_hsa030300.46361384
151Fatty acid degradation_Homo sapiens_hsa000710.45521393
152Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39265511
153Primary immunodeficiency_Homo sapiens_hsa053400.36128358
154Histidine metabolism_Homo sapiens_hsa003400.35413175
155Estrogen signaling pathway_Homo sapiens_hsa049150.34141657
156Metabolic pathways_Homo sapiens_hsa011000.31001703
157Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30820008
1582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.28154231
159Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.26370218
160Colorectal cancer_Homo sapiens_hsa052100.26169819
161Wnt signaling pathway_Homo sapiens_hsa043100.24283128
162AMPK signaling pathway_Homo sapiens_hsa041520.24111633
163Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.22585649

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