DENND1C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1C, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.73359934
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.86039977
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.86039977
4antigen processing and presentation of endogenous antigen (GO:0019883)5.60725838
5negative regulation of cell killing (GO:0031342)5.52218503
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.52218503
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.29643954
8regulation of gamma-delta T cell differentiation (GO:0045586)5.26511495
9regulation of B cell receptor signaling pathway (GO:0050855)5.09041776
10negative T cell selection (GO:0043383)5.05317381
11negative thymic T cell selection (GO:0045060)5.04356583
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.97921013
13positive thymic T cell selection (GO:0045059)4.90809488
14regulation of gamma-delta T cell activation (GO:0046643)4.90776788
15response to interleukin-15 (GO:0070672)4.59631883
16leukocyte aggregation (GO:0070486)4.50086091
17positive regulation by symbiont of host defense response (GO:0052509)4.48506198
18modulation by symbiont of host defense response (GO:0052031)4.48506198
19modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.48506198
20modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.48506198
21positive regulation by organism of defense response of other organism involved in symbiotic interact4.48506198
22modulation by symbiont of host immune response (GO:0052553)4.48506198
23detection of bacterium (GO:0016045)4.44142788
24detection of other organism (GO:0098543)4.36647004
25cellular response to interleukin-15 (GO:0071350)4.34319088
26T cell migration (GO:0072678)4.33538934
27positive regulation of B cell differentiation (GO:0045579)4.33436699
28regulation of B cell differentiation (GO:0045577)4.33348141
29thymic T cell selection (GO:0045061)4.27821021
30interferon-gamma production (GO:0032609)4.27032375
31neutrophil activation involved in immune response (GO:0002283)4.21668890
32B cell receptor signaling pathway (GO:0050853)4.21391349
33positive T cell selection (GO:0043368)4.16915572
34T cell selection (GO:0045058)4.11510904
35regulation of interleukin-12 biosynthetic process (GO:0045075)4.07588124
36regulation of T cell tolerance induction (GO:0002664)4.03426666
37positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.02350453
38mast cell activation (GO:0045576)3.85661585
39regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.82755840
40negative regulation of T cell mediated immunity (GO:0002710)3.73902213
41regulation of isotype switching to IgG isotypes (GO:0048302)3.72476496
42regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.70843805
43macrophage activation involved in immune response (GO:0002281)3.68416273
44tolerance induction (GO:0002507)3.67761908
45negative regulation of leukocyte mediated immunity (GO:0002704)3.66560297
46antigen receptor-mediated signaling pathway (GO:0050851)3.62995524
47antigen processing and presentation via MHC class Ib (GO:0002475)3.62114501
48regulation of alpha-beta T cell proliferation (GO:0046640)3.59524760
49immunoglobulin mediated immune response (GO:0016064)3.56784299
50response to type I interferon (GO:0034340)3.54258881
51response to peptidoglycan (GO:0032494)3.52588550
52T cell receptor signaling pathway (GO:0050852)3.51089053
53NIK/NF-kappaB signaling (GO:0038061)3.50047437
54regulation of regulatory T cell differentiation (GO:0045589)3.49954978
55response to muramyl dipeptide (GO:0032495)3.49353045
56cellular response to type I interferon (GO:0071357)3.49124720
57type I interferon signaling pathway (GO:0060337)3.49124720
58mature B cell differentiation (GO:0002335)3.45737013
59positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.39081888
60neutrophil activation (GO:0042119)3.37473077
61regulation of dendritic cell antigen processing and presentation (GO:0002604)3.37040152
62regulation of interferon-beta biosynthetic process (GO:0045357)3.36152039
63positive regulation of tolerance induction (GO:0002645)3.36110714
64T cell homeostasis (GO:0043029)3.35569016
65detection of external biotic stimulus (GO:0098581)3.35533360
66respiratory burst (GO:0045730)3.33430609
67regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.29241210
68regulation of tolerance induction (GO:0002643)3.29219060
69regulation of T cell receptor signaling pathway (GO:0050856)3.28695747
70T cell costimulation (GO:0031295)3.28196195
71positive regulation of interleukin-2 production (GO:0032743)3.26864487
72regulation of interleukin-2 biosynthetic process (GO:0045076)3.26726925
73interferon-gamma-mediated signaling pathway (GO:0060333)3.26097915
74regulation of type I interferon-mediated signaling pathway (GO:0060338)3.23748176
75lymphocyte costimulation (GO:0031294)3.23332724
76positive regulation of alpha-beta T cell proliferation (GO:0046641)3.22556515
77negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.21999694
78negative regulation of interleukin-12 production (GO:0032695)3.20639217
79germinal center formation (GO:0002467)3.19642044
80positive regulation of isotype switching (GO:0045830)3.18412913
81leukocyte cell-cell adhesion (GO:0007159)3.17278469
82myeloid cell activation involved in immune response (GO:0002275)3.16142854
83defense response to protozoan (GO:0042832)3.15663342
84regulation of antigen processing and presentation (GO:0002577)3.13820747
85myeloid dendritic cell activation (GO:0001773)3.13118011
86regulation of T cell mediated cytotoxicity (GO:0001914)3.11716837
87lymphocyte homeostasis (GO:0002260)3.11337332
88cellular extravasation (GO:0045123)3.09928812
89response to host immune response (GO:0052572)3.09684380
90response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.09684380
91granulocyte activation (GO:0036230)3.08695476
92response to protozoan (GO:0001562)3.08209512
93positive regulation of interferon-alpha production (GO:0032727)3.05701844
94negative regulation of innate immune response (GO:0045824)3.03472763
95mature B cell differentiation involved in immune response (GO:0002313)3.03038917
96cellular response to interferon-beta (GO:0035458)3.01979259
97regulation of mast cell degranulation (GO:0043304)3.01184139
98negative regulation of erythrocyte differentiation (GO:0045647)3.00236002
99regulation of response to interferon-gamma (GO:0060330)2.99265066
100mast cell degranulation (GO:0043303)2.97525734
101mast cell activation involved in immune response (GO:0002279)2.97525734
102positive regulation of T cell mediated cytotoxicity (GO:0001916)2.97304773
103regulation of interferon-alpha production (GO:0032647)2.95700423
104regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.95409364
105JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.94428395
106negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.94067207
107negative regulation of alpha-beta T cell activation (GO:0046636)2.92172676
108detection of biotic stimulus (GO:0009595)2.92095733
109leukocyte degranulation (GO:0043299)2.92072637
110positive regulation of antigen processing and presentation (GO:0002579)2.91914301
111lymph node development (GO:0048535)2.91617766
112positive regulation of granulocyte differentiation (GO:0030854)2.89979110
113B cell mediated immunity (GO:0019724)2.89690667
114regulation of isotype switching (GO:0045191)2.89449203
115activated T cell proliferation (GO:0050798)2.89298981
116response to host (GO:0075136)2.88411602
117response to host defenses (GO:0052200)2.88411602
118response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.88411602
119regulation of natural killer cell mediated immunity (GO:0002715)2.87550642
120regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.87550642
121regulation of B cell mediated immunity (GO:0002712)2.84910147
122natural killer cell activation (GO:0030101)2.84607265
123positive regulation of B cell mediated immunity (GO:0002714)2.83522117
124positive regulation of immunoglobulin mediated immune response (GO:0002891)2.83522117
125Arp2/3 complex-mediated actin nucleation (GO:0034314)2.83476071
126B cell homeostasis (GO:0001782)2.82559485
127leukocyte homeostasis (GO:0001776)2.81898045
128positive regulation of humoral immune response (GO:0002922)2.81049592
129negative regulation of phagocytosis (GO:0050765)2.80318786
130positive regulation of DNA recombination (GO:0045911)2.80093672
131immune response-activating cell surface receptor signaling pathway (GO:0002429)2.80011411
132negative regulation of lymphocyte mediated immunity (GO:0002707)2.79723190
133T cell proliferation (GO:0042098)2.78874304
134regulation of immunoglobulin mediated immune response (GO:0002889)2.78115823
135positive regulation of B cell activation (GO:0050871)2.77195437

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.13288578
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.10748986
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.56259853
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.01018821
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.83742704
6* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.70237866
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.47542374
8SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.23608150
9MYC_22102868_ChIP-Seq_BL_Human3.15005178
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.06869324
11SCL_19346495_ChIP-Seq_HPC-7_Human2.99597830
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.95867826
13RUNX_20019798_ChIP-Seq_JUKART_Human2.86542325
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.85375944
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.84884761
16FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.84356710
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.78688532
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.73863909
19MYB_26560356_Chip-Seq_TH2_Human2.73487342
20VDR_21846776_ChIP-Seq_THP-1_Human2.71894838
21E2F7_22180533_ChIP-Seq_HELA_Human2.68714773
22MAF_26560356_Chip-Seq_TH1_Human2.59560667
23NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.55717068
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.54505184
25* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.52722448
26MYB_21317192_ChIP-Seq_ERMYB_Mouse2.50259550
27* SPI1_23547873_ChIP-Seq_NB4_Human2.43116918
28MYB_26560356_Chip-Seq_TH1_Human2.40633364
29UTX_26944678_Chip-Seq_JUKART_Human2.27734736
30RUNX1_22412390_ChIP-Seq_EML_Mouse2.15654455
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.13040842
32VDR_24763502_ChIP-Seq_THP-1_Human2.11809302
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.03013456
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.00748815
35TCF7_22412390_ChIP-Seq_EML_Mouse1.97171048
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.96146415
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.95940452
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.91919758
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.84480572
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.80276424
41SPI1_23127762_ChIP-Seq_K562_Human1.76838986
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.76044920
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.74125321
44MAF_26560356_Chip-Seq_TH2_Human1.73490255
45SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.71831254
46GATA3_27048872_Chip-Seq_THYMUS_Human1.70762488
47KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.61870530
48LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.58168518
49LXR_22292898_ChIP-Seq_THP-1_Human1.54972930
50GATA2_22383799_ChIP-Seq_G1ME_Mouse1.52049908
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.48743701
52PU_27001747_Chip-Seq_BMDM_Mouse1.45921842
53LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.45159276
54RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.44065679
55CIITA_25753668_ChIP-Seq_RAJI_Human1.42163294
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.40404494
57CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35342996
58KDM2B_26808549_Chip-Seq_DND41_Human1.35000700
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.34235624
60GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.31169441
61GATA1_22383799_ChIP-Seq_G1ME_Mouse1.29335125
62PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26098623
63TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.22397743
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21592211
65CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21154159
66GATA3_26560356_Chip-Seq_TH2_Human1.20630053
67GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.19980463
68GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19363272
69ELK3_25401928_ChIP-Seq_HUVEC_Human1.19143519
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18299407
71FOXM1_23109430_ChIP-Seq_U2OS_Human1.18266454
72KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17845082
73BCOR_27268052_Chip-Seq_Bcells_Human1.17521574
74GATA1_19941827_ChIP-Seq_MEL_Mouse1.16410860
75Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.13285409
76PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09793733
77ELF1_20517297_ChIP-Seq_JURKAT_Human1.06783265
78GATA1_22025678_ChIP-Seq_K562_Human1.06463820
79STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05412603
80EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.04491483
81SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04381333
82CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04327977
83SA1_27219007_Chip-Seq_ERYTHROID_Human1.02243814
84CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01845857
85PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00994243
86RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.99568810
87CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98928624
88VDR_23849224_ChIP-Seq_CD4+_Human0.97950759
89IKZF1_21737484_ChIP-ChIP_HCT116_Human0.97725309
90FOXP3_21729870_ChIP-Seq_TREG_Human0.96551668
91P68_20966046_ChIP-Seq_HELA_Human0.94854782
92TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91443545
93* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.90749385
94STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89120042
95GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88997387
96RACK7_27058665_Chip-Seq_MCF-7_Human0.88430682
97PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86870158
98SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85520563
99CTCF_21964334_ChIP-Seq_BJAB-B_Human0.83597537
100NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.83371137
101THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.82802152
102NCOR1_26117541_ChIP-Seq_K562_Human0.82665320
103FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82094522
104STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.82028389
105PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81861782
106ETS1_22383799_ChIP-Seq_G1ME_Mouse0.81192773
107RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78652710
108* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.77955233
109VDR_24787735_ChIP-Seq_THP-1_Human0.75640072
110SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.73297874
111TFEB_21752829_ChIP-Seq_HELA_Human0.72662457
112* BCL6_27268052_Chip-Seq_Bcells_Human0.72425251
113GATA1_19941826_ChIP-Seq_K562_Human0.72329074
114GATA2_19941826_ChIP-Seq_K562_Human0.71595742
115E2F4_17652178_ChIP-ChIP_JURKAT_Human0.71473568
116KDM2B_26808549_Chip-Seq_JURKAT_Human0.71360400

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.25892741
2MP0005671_abnormal_response_to3.85254077
3MP0000685_abnormal_immune_system3.61529998
4MP0003763_abnormal_thymus_physiology3.59185317
5MP0001800_abnormal_humoral_immune3.38521443
6MP0005387_immune_system_phenotype3.19523622
7MP0001790_abnormal_immune_system3.19523622
8MP0005000_abnormal_immune_tolerance2.97058409
9MP0009785_altered_susceptibility_to2.95538086
10MP0002452_abnormal_antigen_presenting2.91448421
11MP0002723_abnormal_immune_serum2.88061611
12MP0002420_abnormal_adaptive_immunity2.83356703
13MP0001819_abnormal_immune_cell2.80509325
14MP0003436_decreased_susceptibility_to2.79946769
15MP0005025_abnormal_response_to2.73021551
16MP0002396_abnormal_hematopoietic_system2.70897384
17MP0002398_abnormal_bone_marrow2.65335038
18MP0002166_altered_tumor_susceptibility2.55245760
19MP0002419_abnormal_innate_immunity2.50177469
20MP0002148_abnormal_hypersensitivity_rea2.46910036
21MP0005464_abnormal_platelet_physiology2.41270571
22MP0000716_abnormal_immune_system2.39369494
23MP0001873_stomach_inflammation2.34800625
24MP0003303_peritoneal_inflammation2.29961908
25MP0006082_CNS_inflammation2.27142236
26MP0002405_respiratory_system_inflammati2.24928736
27MP0009333_abnormal_splenocyte_physiolog2.24592128
28MP0000689_abnormal_spleen_morphology2.23868791
29MP0002722_abnormal_immune_system2.15880142
30MP0002006_tumorigenesis2.05079034
31MP0003724_increased_susceptibility_to2.04164702
32MP0010155_abnormal_intestine_physiology2.00567686
33MP0002429_abnormal_blood_cell2.00001794
34MP0004808_abnormal_hematopoietic_stem1.99757655
35MP0000703_abnormal_thymus_morphology1.93011834
36MP0004947_skin_inflammation1.89157935
37MP0003300_gastrointestinal_ulcer1.85169052
38MP0003866_abnormal_defecation1.84713101
39MP0001853_heart_inflammation1.83500195
40MP0001845_abnormal_inflammatory_respons1.82049374
41MP0000465_gastrointestinal_hemorrhage1.71867751
42MP0004510_myositis1.69225421
43MP0005174_abnormal_tail_pigmentation1.66251473
44MP0005397_hematopoietic_system_phenotyp1.62858959
45MP0001545_abnormal_hematopoietic_system1.62858959
46MP0009278_abnormal_bone_marrow1.61384648
47MP0005451_abnormal_body_composition1.58731486
48MP0002933_joint_inflammation1.52657146
49MP0008469_abnormal_protein_level1.38458371
50MP0005075_abnormal_melanosome_morpholog1.35027024
51MP0008260_abnormal_autophagy1.31217230
52MP0000490_abnormal_crypts_of1.30118055
53MP0001533_abnormal_skeleton_physiology1.29165480
54MP0005058_abnormal_lysosome_morphology1.27200976
55MP0005310_abnormal_salivary_gland1.24066428
56MP0000858_altered_metastatic_potential1.21793926
57MP0003172_abnormal_lysosome_physiology1.18652959
58MP0003191_abnormal_cellular_cholesterol1.15096010
59MP0000569_abnormal_digit_pigmentation1.06509325
60MP0003448_altered_tumor_morphology1.03886356
61MP0003183_abnormal_peptide_metabolism1.02251407
62MP0000015_abnormal_ear_pigmentation1.01749146
63MP0002019_abnormal_tumor_incidence0.96337270
64MP0001851_eye_inflammation0.95512949
65MP0009764_decreased_sensitivity_to0.92880517
66MP0008057_abnormal_DNA_replication0.86859398
67MP0002095_abnormal_skin_pigmentation0.83144762
68MP0002132_abnormal_respiratory_system0.82688992
69MP0004883_abnormal_blood_vessel0.82114289
70MP0002138_abnormal_hepatobiliary_system0.81877769
71MP0002009_preneoplasia0.81541845
72MP0002998_abnormal_bone_remodeling0.81450491
73MP0009763_increased_sensitivity_to0.77474742
74MP0000371_diluted_coat_color0.76839749
75MP0000343_altered_response_to0.75235646
76MP0003045_fibrosis0.74268426
77MP0008004_abnormal_stomach_pH0.73687256
78MP0003077_abnormal_cell_cycle0.72655869
79MP0003693_abnormal_embryo_hatching0.72135171
80MP0005023_abnormal_wound_healing0.69639588
81MP0003806_abnormal_nucleotide_metabolis0.67542104
82MP0000604_amyloidosis0.66918848
83MP0001663_abnormal_digestive_system0.65838608
84MP0003828_pulmonary_edema0.64650933
85MP0005166_decreased_susceptibility_to0.64298096
86MP0010352_gastrointestinal_tract_polyps0.63554363
87MP0001986_abnormal_taste_sensitivity0.62825459
88MP0002277_abnormal_respiratory_mucosa0.60587064
89MP0010094_abnormal_chromosome_stability0.60144566
90MP0004264_abnormal_extraembryonic_tissu0.59763167
91MP0002136_abnormal_kidney_physiology0.59164295
92MP0003690_abnormal_glial_cell0.58288540
93MP0004381_abnormal_hair_follicle0.58286695
94MP0010307_abnormal_tumor_latency0.58118940
95MP0000249_abnormal_blood_vessel0.57864041
96MP0002928_abnormal_bile_duct0.57836341
97MP0009840_abnormal_foam_cell0.57798362
98MP0002693_abnormal_pancreas_physiology0.57582268
99MP0008058_abnormal_DNA_repair0.57152236
100MP0009765_abnormal_xenobiotic_induced0.55507013
101MP0000313_abnormal_cell_death0.55375187
102MP0005164_abnormal_response_to0.55113285
103MP0000477_abnormal_intestine_morphology0.54663142
104MP0000609_abnormal_liver_physiology0.54344128
105MP0008874_decreased_physiological_sensi0.52564872
106MP0005381_digestive/alimentary_phenotyp0.52299739
107MP0008007_abnormal_cellular_replicative0.51651037
108MP0008961_abnormal_basal_metabolism0.51644834
109MP0003795_abnormal_bone_structure0.51027435
110MP0003091_abnormal_cell_migration0.48057459
111MP0003075_altered_response_to0.47984716
112MP0005390_skeleton_phenotype0.46618169
113MP0003943_abnormal_hepatobiliary_system0.45761947
114MP0003656_abnormal_erythrocyte_physiolo0.45423994
115MP0003453_abnormal_keratinocyte_physiol0.45324430
116MP0004185_abnormal_adipocyte_glucose0.44534583
117MP0003252_abnormal_bile_duct0.42259391
118MP0009115_abnormal_fat_cell0.42075135

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.17849374
2Elevated erythrocyte sedimentation rate (HP:0003565)5.06709799
3Myositis (HP:0100614)4.81841051
4Eczematoid dermatitis (HP:0000976)4.66819019
5Recurrent bacterial skin infections (HP:0005406)4.62354224
6Recurrent fungal infections (HP:0002841)4.57875344
7Recurrent viral infections (HP:0004429)4.52582043
8IgM deficiency (HP:0002850)4.46582092
9T lymphocytopenia (HP:0005403)4.43973332
10Abnormality of T cell number (HP:0011839)4.29952583
11Recurrent bronchitis (HP:0002837)4.28254139
12Panhypogammaglobulinemia (HP:0003139)4.24885865
13Chronic otitis media (HP:0000389)4.21756546
14Abnormal delayed hypersensitivity skin test (HP:0002963)4.03470504
15Chronic mucocutaneous candidiasis (HP:0002728)4.01836868
16Recurrent cutaneous fungal infections (HP:0011370)4.01836868
17Pustule (HP:0200039)3.84638267
18Agammaglobulinemia (HP:0004432)3.82791284
19Abnormality of T cells (HP:0002843)3.80692226
20Recurrent skin infections (HP:0001581)3.74536452
21Meningitis (HP:0001287)3.64288005
22Stomatitis (HP:0010280)3.61694457
23Inflammation of the large intestine (HP:0002037)3.48377189
24Nasal polyposis (HP:0100582)3.47898172
25Thrombocytosis (HP:0001894)3.47891370
26Lymphopenia (HP:0001888)3.40392942
27Gastrointestinal inflammation (HP:0004386)3.39307580
28Vasculitis (HP:0002633)3.37925693
29Abnormality of the fingertips (HP:0001211)3.37359491
30Mediastinal lymphadenopathy (HP:0100721)3.36703041
31Autoimmune thrombocytopenia (HP:0001973)3.34116088
32Thyroiditis (HP:0100646)3.32994849
33Severe combined immunodeficiency (HP:0004430)3.31582655
34Optic neuritis (HP:0100653)3.30991982
35Retrobulbar optic neuritis (HP:0100654)3.30991982
36Abnormality of cells of the lymphoid lineage (HP:0012140)3.26735141
37Colitis (HP:0002583)3.23506661
38Orchitis (HP:0100796)3.21823431
39Combined immunodeficiency (HP:0005387)3.17574414
40Chronic diarrhea (HP:0002028)3.13563868
41Abnormality of T cell physiology (HP:0011840)3.13518280
42Abnormality of the nasal mucosa (HP:0000433)3.13335215
43Cellulitis (HP:0100658)3.13287185
44Prolonged bleeding time (HP:0003010)3.13195535
45Urticaria (HP:0001025)3.10303430
46Abnormality of B cell number (HP:0010975)3.05666117
47B lymphocytopenia (HP:0010976)3.05666117
48IgG deficiency (HP:0004315)3.05651026
49Leukocytosis (HP:0001974)3.05548032
50Gastrointestinal stroma tumor (HP:0100723)3.02881699
51Recurrent gram-negative bacterial infections (HP:0005420)3.02409296
52Increased IgM level (HP:0003496)2.99979715
53Chronic obstructive pulmonary disease (HP:0006510)2.95953037
54Obstructive lung disease (HP:0006536)2.95953037
55Spontaneous hematomas (HP:0007420)2.93123023
56Recurrent sinusitis (HP:0011108)2.89342746
57Abnormality of macrophages (HP:0004311)2.87841200
58Eosinophilia (HP:0001880)2.83861548
59Abnormality of eosinophils (HP:0001879)2.83776210
60Encephalitis (HP:0002383)2.82159651
61Petechiae (HP:0000967)2.81525992
62Epistaxis (HP:0000421)2.80929197
63Hypochromic anemia (HP:0001931)2.70043797
64Arterial thrombosis (HP:0004420)2.68748050
65Granulocytopenia (HP:0001913)2.66359456
66Hemoptysis (HP:0002105)2.59334610
67Periodontitis (HP:0000704)2.54952046
68Pulmonary infiltrates (HP:0002113)2.54211665
69IgA deficiency (HP:0002720)2.51657735
70Increased IgE level (HP:0003212)2.49257561
71Gingival bleeding (HP:0000225)2.48122307
72Impaired platelet aggregation (HP:0003540)2.46920517
73Abnormal platelet function (HP:0011869)2.46920517
74Lymphoma (HP:0002665)2.43576796
75Autoimmune hemolytic anemia (HP:0001890)2.43420078
76Pulmonary embolism (HP:0002204)2.42062335
77Vacuolated lymphocytes (HP:0001922)2.40060078
78Bronchitis (HP:0012387)2.39501579
79Chest pain (HP:0100749)2.38443394
80Gingivitis (HP:0000230)2.38298532
81Episodic fever (HP:0001954)2.37926398
82Emphysema (HP:0002097)2.37228060
83Keratoconjunctivitis sicca (HP:0001097)2.35537199
84Papilloma (HP:0012740)2.32381740
85Verrucae (HP:0200043)2.32381740
86Chronic sinusitis (HP:0011109)2.32146328
87Interstitial pulmonary disease (HP:0006530)2.31470851
88Hypochromic microcytic anemia (HP:0004840)2.29059417
89Joint swelling (HP:0001386)2.24210483
90Anorexia (HP:0002039)2.22083437
91Fatigue (HP:0012378)2.20533158
92Hypoplasia of the thymus (HP:0000778)2.18285801
93Abnormality of the pleura (HP:0002103)2.16790694
94Purpura (HP:0000979)2.16017881
95Osteomyelitis (HP:0002754)2.14510647
96Viral hepatitis (HP:0006562)2.12098451
97Keratoconjunctivitis (HP:0001096)2.11979344
98Skin ulcer (HP:0200042)2.10542679
99Papilledema (HP:0001085)2.10415215
100Cheilitis (HP:0100825)2.10350128
101Hypergammaglobulinemia (HP:0010702)2.10045312
102Gangrene (HP:0100758)2.09158733
103Gastrointestinal infarctions (HP:0005244)2.08911762
104Restrictive lung disease (HP:0002091)2.07671521
105Recurrent pneumonia (HP:0006532)2.06117924
106Skin rash (HP:0000988)2.03761511
107Abnormality of the prostate (HP:0008775)2.03737454
108Premature loss of primary teeth (HP:0006323)2.03516994
109Hematochezia (HP:0002573)2.01096132
110Slow saccadic eye movements (HP:0000514)1.99139403
111Microcytic anemia (HP:0001935)1.97670843
112Increased serum ferritin (HP:0003281)1.96842717
113Recurrent lower respiratory tract infections (HP:0002783)1.96619569
114Amaurosis fugax (HP:0100576)1.96003372
115Systemic lupus erythematosus (HP:0002725)1.95544346
116Sepsis (HP:0100806)1.94585172
117Arthralgia (HP:0002829)1.92900714
118Increased cerebral lipofuscin (HP:0011813)1.91602947

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.89130355
2TXK3.95748628
3JAK32.96476005
4PRPF4B2.92975282
5ZAP702.80787463
6TYK22.80122335
7KIT2.59182922
8IKBKE2.51413310
9BLK2.42726820
10TBK12.23640169
11STK102.23089167
12MAP3K142.20792679
13IRAK42.20007798
14ITK2.19732315
15BTK2.19279474
16MAP3K132.01726397
17JAK12.01710517
18FGFR42.01381373
19CSF1R1.97066042
20TEC1.92451028
21SYK1.91526420
22TGFBR21.86531748
23GRK61.84615718
24LCK1.78606247
25SIK21.72347525
26MAP3K101.67847836
27RIPK41.63678869
28HCK1.56967214
29IKBKB1.56194914
30EEF2K1.48415257
31CSK1.43238658
32IRAK31.42077145
33FES1.33229611
34FGFR31.30392709
35NLK1.27944484
36MAP3K31.27165921
37SMG11.24256236
38LYN1.21869374
39MARK31.18980388
40NME21.14939112
41FGR1.12402034
42PIM11.11629994
43LRRK21.10381817
44TAOK31.10073794
45MAP2K31.09013319
46CLK11.06937510
47ERN11.06462141
48SIK31.06417951
49RPS6KA41.02408568
50MAP3K11.01165572
51FLT30.97818795
52CHUK0.95237726
53PASK0.93545847
54JAK20.88705570
55CDC42BPA0.84071427
56TAOK20.83080079
57MAP2K20.78864550
58EPHB10.78700213
59PRKCQ0.75654091
60TGFBR10.72885351
61KDR0.72676289
62CDK120.68594788
63BMPR20.68410712
64PRKCH0.68393460
65TNK20.65900019
66CAMKK10.65377060
67PKN20.65275887
68CDK190.65112946
69MAP3K70.63510338
70NEK20.61649116
71KSR20.61409783
72IRAK10.60095742
73PDPK10.59494751
74CDK40.56984678
75STK40.53699752
76MAPK110.50814197
77PDK10.48332751
78MST40.47934205
79HIPK20.47018057
80TESK20.45452834
81DYRK1B0.45087971
82TRPM70.44814187
83MAP3K120.44499288
84BRD40.43130026
85TRIB30.43031821
86RPS6KC10.42163852
87RPS6KL10.42163852
88CAMK1D0.41682391
89IRAK20.41441808
90MAPK120.40499855
91CAMK1G0.39979238
92PRKD20.37997159
93PIM20.37065251
94MAPK40.36539570
95SGK30.36504566
96MAPK70.34686565
97ABL10.34649542
98PTK60.34509741
99RPS6KA60.33885071
100CDK60.32979037
101MELK0.32330686
102TAOK10.32311273
103STK110.32134656
104MATK0.31788752
105CAMKK20.30746866
106ADRBK20.30511035
107SIK10.30100823
108RET0.30063795
109MAPKAPK20.29907561
110NEK90.29764008
111BMX0.29471701
112TTN0.29460592
113IGF1R0.29034092
114YES10.28422340
115MARK20.28387722
116EGFR0.27971554
117PDGFRB0.27767257
118FYN0.27487595
119CDK90.27277105
120ATR0.26618015
121PRKCD0.26052343
122MAPK30.24979587
123MAP3K50.24657721
124PIK3CG0.24521872
125MAP3K110.24181187
126EPHA30.24143101
127RPS6KB20.23986561
128MAP2K60.22503369

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.56625884
2B cell receptor signaling pathway_Homo sapiens_hsa046622.74466916
3Leishmaniasis_Homo sapiens_hsa051402.67711273
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.67614528
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.65190757
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.64928712
7Measles_Homo sapiens_hsa051622.57414645
8T cell receptor signaling pathway_Homo sapiens_hsa046602.48685513
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.47388172
10Hematopoietic cell lineage_Homo sapiens_hsa046402.44554277
11Osteoclast differentiation_Homo sapiens_hsa043802.35377194
12Antigen processing and presentation_Homo sapiens_hsa046122.12141435
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.99047389
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.98690758
15Allograft rejection_Homo sapiens_hsa053301.95324561
16Graft-versus-host disease_Homo sapiens_hsa053321.92162861
17Staphylococcus aureus infection_Homo sapiens_hsa051501.89515247
18Herpes simplex infection_Homo sapiens_hsa051681.84751473
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.84093511
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.82036473
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.72503461
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.70360505
23Influenza A_Homo sapiens_hsa051641.53433573
24Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.53271342
25Toxoplasmosis_Homo sapiens_hsa051451.46911119
26Chemokine signaling pathway_Homo sapiens_hsa040621.46364041
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.38101654
28Acute myeloid leukemia_Homo sapiens_hsa052211.37670877
29Leukocyte transendothelial migration_Homo sapiens_hsa046701.35499502
30Viral myocarditis_Homo sapiens_hsa054161.34462554
31Tuberculosis_Homo sapiens_hsa051521.34133459
32Pertussis_Homo sapiens_hsa051331.32448430
33Hepatitis B_Homo sapiens_hsa051611.31257825
34Shigellosis_Homo sapiens_hsa051311.27411239
35Legionellosis_Homo sapiens_hsa051341.24779824
36Other glycan degradation_Homo sapiens_hsa005111.23761979
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.22599916
38Apoptosis_Homo sapiens_hsa042101.20922037
39TNF signaling pathway_Homo sapiens_hsa046681.18538868
40Platelet activation_Homo sapiens_hsa046111.17801499
41Malaria_Homo sapiens_hsa051441.15397237
42Asthma_Homo sapiens_hsa053101.12472489
43Autoimmune thyroid disease_Homo sapiens_hsa053201.12240867
44Caffeine metabolism_Homo sapiens_hsa002321.09859246
45Ribosome_Homo sapiens_hsa030101.04671943
46Transcriptional misregulation in cancer_Homo sapiens_hsa052021.01256089
47Base excision repair_Homo sapiens_hsa034101.00335806
48Pancreatic cancer_Homo sapiens_hsa052121.00180318
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.00138078
50Chronic myeloid leukemia_Homo sapiens_hsa052200.98002134
51Hepatitis C_Homo sapiens_hsa051600.96394224
52DNA replication_Homo sapiens_hsa030300.95069809
53Epstein-Barr virus infection_Homo sapiens_hsa051690.94724032
54Salmonella infection_Homo sapiens_hsa051320.89096047
55Phagosome_Homo sapiens_hsa041450.87454710
56Non-homologous end-joining_Homo sapiens_hsa034500.84568598
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83491190
58HTLV-I infection_Homo sapiens_hsa051660.81411412
59Mismatch repair_Homo sapiens_hsa034300.80874462
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80807822
61Prolactin signaling pathway_Homo sapiens_hsa049170.74416449
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73372706
63Notch signaling pathway_Homo sapiens_hsa043300.72417835
64Type I diabetes mellitus_Homo sapiens_hsa049400.72262679
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.71781248
66Viral carcinogenesis_Homo sapiens_hsa052030.66097254
67Glycosaminoglycan degradation_Homo sapiens_hsa005310.66030276
68Rheumatoid arthritis_Homo sapiens_hsa053230.65287107
69Choline metabolism in cancer_Homo sapiens_hsa052310.61797326
70Lysosome_Homo sapiens_hsa041420.61518074
71Renal cell carcinoma_Homo sapiens_hsa052110.61319015
72African trypanosomiasis_Homo sapiens_hsa051430.59505236
73Non-small cell lung cancer_Homo sapiens_hsa052230.59337840
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59013385
75p53 signaling pathway_Homo sapiens_hsa041150.58186702
76VEGF signaling pathway_Homo sapiens_hsa043700.57998922
77Colorectal cancer_Homo sapiens_hsa052100.55492170
78Endometrial cancer_Homo sapiens_hsa052130.55169521
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.54387755
80Small cell lung cancer_Homo sapiens_hsa052220.53435148
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49561377
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.49360082
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49331678
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47929123
85Homologous recombination_Homo sapiens_hsa034400.46451860
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46440652
87Spliceosome_Homo sapiens_hsa030400.46026590
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45971915
89Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45590820
90mTOR signaling pathway_Homo sapiens_hsa041500.45496875
91GnRH signaling pathway_Homo sapiens_hsa049120.42473628
92ABC transporters_Homo sapiens_hsa020100.41217173
93FoxO signaling pathway_Homo sapiens_hsa040680.38516290
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38371550
95Prostate cancer_Homo sapiens_hsa052150.37792584
96RNA degradation_Homo sapiens_hsa030180.37485615
97Endocytosis_Homo sapiens_hsa041440.37398289
98Inositol phosphate metabolism_Homo sapiens_hsa005620.37112500
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.37087937
100Insulin resistance_Homo sapiens_hsa049310.35709475
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35042480
102Thyroid cancer_Homo sapiens_hsa052160.30922281
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30103765
104HIF-1 signaling pathway_Homo sapiens_hsa040660.30057935
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.29980185
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29928895
107Nucleotide excision repair_Homo sapiens_hsa034200.28316400
108ErbB signaling pathway_Homo sapiens_hsa040120.27441067
109Amoebiasis_Homo sapiens_hsa051460.22340229
110Lysine degradation_Homo sapiens_hsa003100.21935239
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.21708357
112Type II diabetes mellitus_Homo sapiens_hsa049300.21659368
113Fanconi anemia pathway_Homo sapiens_hsa034600.21420227
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21016848
115MAPK signaling pathway_Homo sapiens_hsa040100.20963666
116Pathways in cancer_Homo sapiens_hsa052000.20644058
117Insulin signaling pathway_Homo sapiens_hsa049100.20638540
118Dorso-ventral axis formation_Homo sapiens_hsa043200.20437851
119Systemic lupus erythematosus_Homo sapiens_hsa053220.19645702
120Rap1 signaling pathway_Homo sapiens_hsa040150.18775826
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.16141069
122Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.15840119

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