DENND2D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)7.16952827
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.74999814
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.74999814
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.16434015
5negative regulation of cell killing (GO:0031342)6.16434015
6antigen processing and presentation of endogenous antigen (GO:0019883)6.05797527
7negative T cell selection (GO:0043383)5.88823522
8regulation of gamma-delta T cell differentiation (GO:0045586)5.76431842
9negative thymic T cell selection (GO:0045060)5.74567338
10positive thymic T cell selection (GO:0045059)5.47846678
11positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.39969664
12regulation of gamma-delta T cell activation (GO:0046643)5.35550129
13response to interleukin-15 (GO:0070672)5.29328715
14cellular response to interleukin-15 (GO:0071350)5.10727692
15thymic T cell selection (GO:0045061)4.94369852
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.93658979
17regulation of isotype switching to IgG isotypes (GO:0048302)4.84229410
18positive T cell selection (GO:0043368)4.80482543
19T cell selection (GO:0045058)4.65156128
20leukocyte aggregation (GO:0070486)4.63507885
21interferon-gamma production (GO:0032609)4.61686107
22positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.41182876
23regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.40902275
24positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.31877630
25antigen processing and presentation via MHC class Ib (GO:0002475)4.16108011
26regulation of B cell receptor signaling pathway (GO:0050855)4.02441275
27T cell receptor signaling pathway (GO:0050852)3.99646062
28regulation of T cell tolerance induction (GO:0002664)3.96348321
29T cell costimulation (GO:0031295)3.95593560
30lymphocyte costimulation (GO:0031294)3.92097684
31T cell migration (GO:0072678)3.90934587
32regulation of T cell receptor signaling pathway (GO:0050856)3.86066476
33activated T cell proliferation (GO:0050798)3.84541467
34regulation of alpha-beta T cell proliferation (GO:0046640)3.73292712
35regulation of response to interferon-gamma (GO:0060330)3.72834628
36detection of bacterium (GO:0016045)3.72692428
37regulation of interleukin-12 biosynthetic process (GO:0045075)3.72338340
38detection of other organism (GO:0098543)3.71443742
39ribosomal small subunit assembly (GO:0000028)3.70188881
40response to type I interferon (GO:0034340)3.69965458
41regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.69224932
42neutrophil activation involved in immune response (GO:0002283)3.68721444
43antigen receptor-mediated signaling pathway (GO:0050851)3.67003244
44negative regulation of interleukin-12 production (GO:0032695)3.66578612
45regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.65981637
46type I interferon signaling pathway (GO:0060337)3.61900693
47cellular response to type I interferon (GO:0071357)3.61900693
48regulation of regulatory T cell differentiation (GO:0045589)3.60507555
49negative regulation of T cell mediated immunity (GO:0002710)3.59124682
50negative regulation of leukocyte mediated immunity (GO:0002704)3.57945534
51modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.53028521
52modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.53028521
53positive regulation by organism of defense response of other organism involved in symbiotic interact3.53028521
54modulation by symbiont of host immune response (GO:0052553)3.53028521
55positive regulation by symbiont of host defense response (GO:0052509)3.53028521
56modulation by symbiont of host defense response (GO:0052031)3.53028521
57positive regulation of tolerance induction (GO:0002645)3.52490201
58positive regulation of natural killer cell mediated immunity (GO:0002717)3.45126453
59positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.45126453
60lymph node development (GO:0048535)3.45023203
61immunoglobulin mediated immune response (GO:0016064)3.44169360
62tolerance induction (GO:0002507)3.41304105
63regulation of interleukin-2 biosynthetic process (GO:0045076)3.41164533
64regulation of B cell differentiation (GO:0045577)3.41066012
65positive regulation of interleukin-2 production (GO:0032743)3.38844044
66positive regulation of immunoglobulin mediated immune response (GO:0002891)3.36144662
67positive regulation of B cell mediated immunity (GO:0002714)3.36144662
68regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.35642747
69regulation of natural killer cell mediated immunity (GO:0002715)3.35642747
70positive regulation of humoral immune response (GO:0002922)3.35592308
71regulation of leukocyte mediated cytotoxicity (GO:0001910)3.34966546
72macrophage activation involved in immune response (GO:0002281)3.34817102
73NIK/NF-kappaB signaling (GO:0038061)3.29537299
74positive regulation of isotype switching (GO:0045830)3.29400448
75regulation of type I interferon-mediated signaling pathway (GO:0060338)3.28370103
76positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.27530923
77regulation of immunoglobulin mediated immune response (GO:0002889)3.24603912
78positive regulation of alpha-beta T cell proliferation (GO:0046641)3.24542551
79regulation of B cell mediated immunity (GO:0002712)3.23835756
80cellular extravasation (GO:0045123)3.23698667
81T cell homeostasis (GO:0043029)3.23008085
82neutrophil activation (GO:0042119)3.21893175
83dendritic cell chemotaxis (GO:0002407)3.18408602
84regulation of T cell mediated cytotoxicity (GO:0001914)3.17087043
85interferon-gamma-mediated signaling pathway (GO:0060333)3.16796159
86T cell differentiation (GO:0030217)3.16185820
87JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.16047082
88regulation of tolerance induction (GO:0002643)3.15449479
89B cell receptor signaling pathway (GO:0050853)3.12369763
90regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.12294781
91negative regulation of erythrocyte differentiation (GO:0045647)3.12288594
92granulocyte activation (GO:0036230)3.11372007
93regulation of isotype switching (GO:0045191)3.08985571
94mature B cell differentiation (GO:0002335)3.08687164
95mature B cell differentiation involved in immune response (GO:0002313)3.08398109
96alpha-beta T cell activation (GO:0046631)3.07690581
97mast cell activation (GO:0045576)3.07147472
98myeloid cell activation involved in immune response (GO:0002275)3.06964596
99regulation of dendritic cell antigen processing and presentation (GO:0002604)3.05643303
100negative regulation of lymphocyte mediated immunity (GO:0002707)3.01358228
101positive regulation of B cell differentiation (GO:0045579)3.00965740
102negative regulation of T cell receptor signaling pathway (GO:0050860)3.00678837
103myeloid dendritic cell differentiation (GO:0043011)3.00582288
104myeloid dendritic cell activation (GO:0001773)2.99981107
105regulation of cell killing (GO:0031341)2.97541721
106dendritic cell migration (GO:0036336)2.96133213
107megakaryocyte development (GO:0035855)2.96119263
108T cell activation (GO:0042110)2.95912414
109lymphocyte migration (GO:0072676)2.95824238
110detection of external biotic stimulus (GO:0098581)2.95811657
111natural killer cell activation (GO:0030101)2.95292545
112respiratory burst (GO:0045730)2.94488628
113negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.92904862
114alpha-beta T cell differentiation (GO:0046632)2.92603991
115defense response to protozoan (GO:0042832)2.91825377
116regulation of alpha-beta T cell activation (GO:0046634)2.91655707
117leukocyte degranulation (GO:0043299)2.90803769
118regulation of antigen processing and presentation (GO:0002577)2.90162765
119leukocyte cell-cell adhesion (GO:0007159)2.88774086
120negative regulation of innate immune response (GO:0045824)2.88663090
121positive regulation of cell killing (GO:0031343)2.88284429
122definitive hemopoiesis (GO:0060216)2.88178844
123Arp2/3 complex-mediated actin nucleation (GO:0034314)2.87755979
124regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.85732218
125positive regulation of DNA recombination (GO:0045911)2.85294125
126regulation of response to tumor cell (GO:0002834)2.85235117
127positive regulation of response to tumor cell (GO:0002836)2.85235117
128positive regulation of immune response to tumor cell (GO:0002839)2.85235117
129regulation of immune response to tumor cell (GO:0002837)2.85235117
130positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.84123175
131positive regulation of antigen processing and presentation (GO:0002579)2.83990746
132negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.82890381
133positive regulation of granulocyte differentiation (GO:0030854)2.80694194
134response to protozoan (GO:0001562)2.80663153
135negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.78449520
136positive regulation of T cell mediated cytotoxicity (GO:0001916)2.77586228

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.41985513
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.33602743
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.93124607
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.05359552
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.51059156
6* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.21974166
7STAT4_19710469_ChIP-ChIP_TH1__Mouse3.03078057
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.02389823
9MYC_22102868_ChIP-Seq_BL_Human2.97497537
10RUNX_20019798_ChIP-Seq_JUKART_Human2.87246244
11* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.85639319
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.83242246
13* MYB_26560356_Chip-Seq_TH2_Human2.80640706
14SCL_19346495_ChIP-Seq_HPC-7_Human2.68015119
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.64841222
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.59424420
17E2F7_22180533_ChIP-Seq_HELA_Human2.58725176
18SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.52712544
19* MAF_26560356_Chip-Seq_TH1_Human2.52323140
20* MYB_26560356_Chip-Seq_TH1_Human2.40219883
21* UTX_26944678_Chip-Seq_JUKART_Human2.29021043
22* NOTCH1_21737748_ChIP-Seq_TLL_Human2.26038573
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.19910301
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.19528785
25VDR_21846776_ChIP-Seq_THP-1_Human2.15903629
26* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.14881911
27MYB_21317192_ChIP-Seq_ERMYB_Mouse2.14841999
28BP1_19119308_ChIP-ChIP_Hs578T_Human2.11210995
29SPI1_23547873_ChIP-Seq_NB4_Human2.10534718
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.03901818
31TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.96880308
32SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.96185224
33* RUNX1_22412390_ChIP-Seq_EML_Mouse1.91451475
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.90988387
35IRF8_27001747_Chip-Seq_BMDM_Mouse1.89901416
36GATA1_22025678_ChIP-Seq_K562_Human1.88929998
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.82704685
38* MAF_26560356_Chip-Seq_TH2_Human1.79060483
39* GATA3_27048872_Chip-Seq_THYMUS_Human1.75874163
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.74097622
41TCF7_22412390_ChIP-Seq_EML_Mouse1.64188251
42SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.63360122
43* VDR_24763502_ChIP-Seq_THP-1_Human1.62405842
44EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.58102805
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.57137308
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.56655953
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.53365601
48* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.51204310
49* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.50531097
50* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.49734406
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.48701426
52Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.46416684
53LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.44313068
54LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.41974161
55VDR_24787735_ChIP-Seq_THP-1_Human1.41229242
56* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.39809192
57STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.39434836
58CIITA_25753668_ChIP-Seq_RAJI_Human1.35814687
59GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.32000308
60GATA1_22383799_ChIP-Seq_G1ME_Mouse1.27532964
61CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.27308266
62SPI1_23127762_ChIP-Seq_K562_Human1.26692774
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25247711
64VDR_23849224_ChIP-Seq_CD4+_Human1.24455787
65GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.22526474
66PU_27001747_Chip-Seq_BMDM_Mouse1.22233452
67* GATA3_26560356_Chip-Seq_TH2_Human1.20179594
68FOXP3_21729870_ChIP-Seq_TREG_Human1.19415995
69* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.19051100
70TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16675243
71CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16344136
72CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13553720
73RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.10625840
74GATA1_19941826_ChIP-Seq_K562_Human1.08590191
75PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05688623
76SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.04242038
77* KDM2B_26808549_Chip-Seq_DND41_Human1.00355931
78STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.00174694
79FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.99266978
80STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97956437
81PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97662217
82VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97498183
83GABP_17652178_ChIP-ChIP_JURKAT_Human0.97320538
84GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96766604
85GATA1_19941827_ChIP-Seq_MEL_Mouse0.95791148
86BCOR_27268052_Chip-Seq_Bcells_Human0.95124229
87NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95067863
88ELK3_25401928_ChIP-Seq_HUVEC_Human0.94308878
89LXR_22292898_ChIP-Seq_THP-1_Human0.93353533
90PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89712225
91SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89349521
92CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88122842
93CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87309653
94* KDM2B_26808549_Chip-Seq_JURKAT_Human0.87184120
95GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86936939
96SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86529265
97GATA2_21666600_ChIP-Seq_HMVEC_Human0.86457330
98TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86303334
99CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.86258940
100MYC_18555785_ChIP-Seq_MESCs_Mouse0.86255928
101CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.84416370
102PPARA_22158963_ChIP-Seq_LIVER_Mouse0.83988656
103ETS1_22383799_ChIP-Seq_G1ME_Mouse0.83814456
104* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81960406
105GATA2_19941826_ChIP-Seq_K562_Human0.81426184
106NCOR1_26117541_ChIP-Seq_K562_Human0.79074104
107NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.78923772
108STAT1_20625510_ChIP-Seq_HELA_Human0.78431802
109RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.78274136
110EGR1_23403033_ChIP-Seq_LIVER_Mouse0.77424474
111PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77397809
112ELK1_19687146_ChIP-ChIP_HELA_Human0.77325280
113PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.76757833
114KDM2B_26808549_Chip-Seq_SUP-B15_Human0.76739295
115ELF1_20517297_ChIP-Seq_JURKAT_Human0.76068206
116SPI1_20517297_ChIP-Seq_HL60_Human0.74487692
117BCL6_27268052_Chip-Seq_Bcells_Human0.73950622
118XRN2_22483619_ChIP-Seq_HELA_Human0.72747320
119* P300_27268052_Chip-Seq_Bcells_Human0.72231136
120VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.72092454
121THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.71804646
122* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68932576

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.73026725
2MP0005671_abnormal_response_to4.03467161
3MP0001835_abnormal_antigen_presentation3.52297953
4MP0000685_abnormal_immune_system3.52237508
5MP0009785_altered_susceptibility_to3.01550355
6MP0001800_abnormal_humoral_immune2.97773570
7MP0002166_altered_tumor_susceptibility2.87487010
8MP0001790_abnormal_immune_system2.82500400
9MP0005387_immune_system_phenotype2.82500400
10MP0005000_abnormal_immune_tolerance2.70748624
11MP0003724_increased_susceptibility_to2.62909664
12MP0002420_abnormal_adaptive_immunity2.60913150
13MP0002723_abnormal_immune_serum2.58024611
14MP0001819_abnormal_immune_cell2.56824753
15MP0005025_abnormal_response_to2.56538420
16MP0001873_stomach_inflammation2.54880642
17MP0002398_abnormal_bone_marrow2.52753838
18MP0002452_abnormal_antigen_presenting2.46910282
19MP0002396_abnormal_hematopoietic_system2.35784397
20MP0003436_decreased_susceptibility_to2.34511055
21MP0010155_abnormal_intestine_physiology2.32649183
22MP0000716_abnormal_immune_system2.24268943
23MP0002405_respiratory_system_inflammati2.22271785
24MP0002006_tumorigenesis2.21854740
25MP0003866_abnormal_defecation2.20704387
26MP0009333_abnormal_splenocyte_physiolog2.15196816
27MP0003300_gastrointestinal_ulcer2.11225918
28MP0002722_abnormal_immune_system2.07519188
29MP0000689_abnormal_spleen_morphology2.06440742
30MP0000703_abnormal_thymus_morphology2.04062844
31MP0004947_skin_inflammation1.94500522
32MP0002419_abnormal_innate_immunity1.93611216
33MP0002148_abnormal_hypersensitivity_rea1.91409631
34MP0005464_abnormal_platelet_physiology1.90156157
35MP0002429_abnormal_blood_cell1.87009506
36MP0001845_abnormal_inflammatory_respons1.78332890
37MP0006082_CNS_inflammation1.72731636
38MP0000465_gastrointestinal_hemorrhage1.67493928
39MP0004808_abnormal_hematopoietic_stem1.64684824
40MP0001853_heart_inflammation1.63214885
41MP0002933_joint_inflammation1.54600164
42MP0005075_abnormal_melanosome_morpholog1.46496568
43MP0003172_abnormal_lysosome_physiology1.46199380
44MP0001545_abnormal_hematopoietic_system1.45755946
45MP0005397_hematopoietic_system_phenotyp1.45755946
46MP0000490_abnormal_crypts_of1.38805119
47MP0008260_abnormal_autophagy1.36920041
48MP0005451_abnormal_body_composition1.33141114
49MP0008469_abnormal_protein_level1.31499777
50MP0000858_altered_metastatic_potential1.30653325
51MP0005174_abnormal_tail_pigmentation1.28036866
52MP0005310_abnormal_salivary_gland1.21232300
53MP0004381_abnormal_hair_follicle1.17858604
54MP0002009_preneoplasia1.12540613
55MP0005058_abnormal_lysosome_morphology1.08104673
56MP0002138_abnormal_hepatobiliary_system1.06635927
57MP0002132_abnormal_respiratory_system1.03844580
58MP0001533_abnormal_skeleton_physiology1.03423050
59MP0003303_peritoneal_inflammation0.98980687
60MP0002693_abnormal_pancreas_physiology0.98612699
61MP0005365_abnormal_bile_salt0.97903662
62MP0009278_abnormal_bone_marrow0.97005343
63MP0010352_gastrointestinal_tract_polyps0.96833169
64MP0005166_decreased_susceptibility_to0.96301784
65MP0009764_decreased_sensitivity_to0.95857012
66MP0002019_abnormal_tumor_incidence0.95668476
67MP0001851_eye_inflammation0.95646301
68MP0002277_abnormal_respiratory_mucosa0.94145340
69MP0001666_abnormal_nutrient_absorption0.93369645
70MP0010234_abnormal_vibrissa_follicle0.87854628
71MP0004510_myositis0.87715597
72MP0003448_altered_tumor_morphology0.87320009
73MP0006054_spinal_hemorrhage0.86999886
74MP0004883_abnormal_blood_vessel0.86126598
75MP0000604_amyloidosis0.86119898
76MP0009840_abnormal_foam_cell0.84107375
77MP0003828_pulmonary_edema0.84023572
78MP0009765_abnormal_xenobiotic_induced0.83597333
79MP0002877_abnormal_melanocyte_morpholog0.83217054
80MP0009763_increased_sensitivity_to0.82489100
81MP0003191_abnormal_cellular_cholesterol0.82375334
82MP0003183_abnormal_peptide_metabolism0.80676320
83MP0005023_abnormal_wound_healing0.80633283
84MP0000609_abnormal_liver_physiology0.78811441
85MP0000477_abnormal_intestine_morphology0.77820178
86MP0003690_abnormal_glial_cell0.77277787
87MP0003075_altered_response_to0.76545933
88MP0004782_abnormal_surfactant_physiolog0.75765768
89MP0003943_abnormal_hepatobiliary_system0.75345985
90MP0003693_abnormal_embryo_hatching0.75024466
91MP0002095_abnormal_skin_pigmentation0.74227674
92MP0000569_abnormal_digit_pigmentation0.70144842
93MP0005083_abnormal_biliary_tract0.70110593
94MP0001663_abnormal_digestive_system0.69523920
95MP0008004_abnormal_stomach_pH0.67796164
96MP0009643_abnormal_urine_homeostasis0.66780408
97MP0003453_abnormal_keratinocyte_physiol0.65852934
98MP0004264_abnormal_extraembryonic_tissu0.64846861
99MP0005390_skeleton_phenotype0.64649319
100MP0002136_abnormal_kidney_physiology0.63902674
101MP0000015_abnormal_ear_pigmentation0.63868113
102MP0001191_abnormal_skin_condition0.63273047
103MP0000249_abnormal_blood_vessel0.63105333
104MP0005164_abnormal_response_to0.62229478
105MP0005220_abnormal_exocrine_pancreas0.61702772
106MP0000343_altered_response_to0.60642365
107MP0009379_abnormal_foot_pigmentation0.60003605
108MP0003868_abnormal_feces_composition0.59754128
109MP0003806_abnormal_nucleotide_metabolis0.59049911
110MP0002998_abnormal_bone_remodeling0.58968339
111MP0000598_abnormal_liver_morphology0.58207371
112MP0001764_abnormal_homeostasis0.57843366
113MP0001216_abnormal_epidermal_layer0.57701621
114MP0002928_abnormal_bile_duct0.56641932
115MP0001765_abnormal_ion_homeostasis0.56536350
116MP0001348_abnormal_lacrimal_gland0.55564888
117MP0003656_abnormal_erythrocyte_physiolo0.55484870
118MP0003795_abnormal_bone_structure0.55195076
119MP0008057_abnormal_DNA_replication0.54540016
120MP0005085_abnormal_gallbladder_physiolo0.53180864
121MP0003045_fibrosis0.52996555
122MP0008874_decreased_physiological_sensi0.51549146
123MP0000367_abnormal_coat/_hair0.49744690
124MP0002254_reproductive_system_inflammat0.49272148
125MP0005381_digestive/alimentary_phenotyp0.47435831
126MP0009115_abnormal_fat_cell0.41942722
127MP0004130_abnormal_muscle_cell0.41841378

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.86165206
2Abnormality of T cell number (HP:0011839)5.69042485
3IgM deficiency (HP:0002850)5.10866042
4Recurrent bronchitis (HP:0002837)5.06868880
5Elevated erythrocyte sedimentation rate (HP:0003565)4.99899129
6Abnormality of T cells (HP:0002843)4.73873774
7Severe combined immunodeficiency (HP:0004430)4.46478816
8Chronic otitis media (HP:0000389)4.38261886
9Combined immunodeficiency (HP:0005387)4.14836436
10Recurrent fungal infections (HP:0002841)4.10215920
11Eczematoid dermatitis (HP:0000976)3.98580866
12Abnormal delayed hypersensitivity skin test (HP:0002963)3.90553360
13Recurrent gram-negative bacterial infections (HP:0005420)3.90258628
14Recurrent viral infections (HP:0004429)3.83295523
15Lymphopenia (HP:0001888)3.82912767
16IgG deficiency (HP:0004315)3.82299437
17Pustule (HP:0200039)3.77796556
18Myositis (HP:0100614)3.77059374
19Recurrent cutaneous fungal infections (HP:0011370)3.77045651
20Chronic mucocutaneous candidiasis (HP:0002728)3.77045651
21Thrombocytosis (HP:0001894)3.77041320
22Abnormality of T cell physiology (HP:0011840)3.76148783
23Chronic diarrhea (HP:0002028)3.73256438
24Abnormality of cells of the lymphoid lineage (HP:0012140)3.67747122
25Panhypogammaglobulinemia (HP:0003139)3.62842823
26Thyroiditis (HP:0100646)3.58481204
27Autoimmune hemolytic anemia (HP:0001890)3.47475475
28Stomatitis (HP:0010280)3.45306137
29Recurrent abscess formation (HP:0002722)3.29307310
30Nasal polyposis (HP:0100582)3.26495424
31Abnormality of B cell number (HP:0010975)3.26320203
32B lymphocytopenia (HP:0010976)3.26320203
33Agammaglobulinemia (HP:0004432)3.23803704
34Autoimmune thrombocytopenia (HP:0001973)3.22888037
35Abnormality of eosinophils (HP:0001879)3.18988041
36Bronchitis (HP:0012387)3.10944021
37Hypoplasia of the thymus (HP:0000778)3.10495958
38Vasculitis (HP:0002633)3.09478703
39Prolonged bleeding time (HP:0003010)3.07597952
40Recurrent sinusitis (HP:0011108)3.07129995
41Gastrointestinal stroma tumor (HP:0100723)3.07015669
42Abnormality of the nasal mucosa (HP:0000433)3.05163201
43IgA deficiency (HP:0002720)3.04409210
44Spontaneous hematomas (HP:0007420)2.99706063
45Abnormality of the fingertips (HP:0001211)2.90684136
46Leukocytosis (HP:0001974)2.89467336
47Meningitis (HP:0001287)2.89111160
48Inflammation of the large intestine (HP:0002037)2.79581802
49Lymphoma (HP:0002665)2.79323290
50Epistaxis (HP:0000421)2.77113536
51Recurrent skin infections (HP:0001581)2.76115488
52Gastrointestinal inflammation (HP:0004386)2.71709062
53Recurrent bacterial skin infections (HP:0005406)2.62647984
54Joint swelling (HP:0001386)2.62138147
55Aplastic anemia (HP:0001915)2.55438129
56Urticaria (HP:0001025)2.55075750
57Pulmonary embolism (HP:0002204)2.54401537
58Hemoptysis (HP:0002105)2.49776237
59Petechiae (HP:0000967)2.49742003
60Poikiloderma (HP:0001029)2.49621787
61Gangrene (HP:0100758)2.49131728
62Interstitial pulmonary disease (HP:0006530)2.48889165
63Increased IgE level (HP:0003212)2.46574096
64Mediastinal lymphadenopathy (HP:0100721)2.46239610
65Granulocytopenia (HP:0001913)2.42334739
66Eosinophilia (HP:0001880)2.41780158
67Encephalitis (HP:0002383)2.41537272
68Anorexia (HP:0002039)2.41333001
69Abnormality of glycolipid metabolism (HP:0010969)2.40635213
70Abnormality of liposaccharide metabolism (HP:0010968)2.40635213
71Abnormality of glycosphingolipid metabolism (HP:0004343)2.40635213
72Periodontitis (HP:0000704)2.39486458
73Orchitis (HP:0100796)2.34890331
74Optic neuritis (HP:0100653)2.32825766
75Retrobulbar optic neuritis (HP:0100654)2.32825766
76Hypochromic anemia (HP:0001931)2.32821811
77Chronic sinusitis (HP:0011109)2.32292524
78Increased IgM level (HP:0003496)2.27909498
79Abnormality of the pleura (HP:0002103)2.27239683
80Basal cell carcinoma (HP:0002671)2.26926948
81Hypergammaglobulinemia (HP:0010702)2.23066852
82Cheilitis (HP:0100825)2.22116921
83Gastrointestinal infarctions (HP:0005244)2.21478379
84Arterial thrombosis (HP:0004420)2.21354402
85Gingival bleeding (HP:0000225)2.20972444
86Abnormal platelet volume (HP:0011876)2.19517674
87Emphysema (HP:0002097)2.17942918
88Colitis (HP:0002583)2.16154446
89Chronic obstructive pulmonary disease (HP:0006510)2.14792536
90Obstructive lung disease (HP:0006536)2.14792536
91Microcytic anemia (HP:0001935)2.12410016
92Increased cerebral lipofuscin (HP:0011813)2.10499368
93Osteomyelitis (HP:0002754)2.10429585
94Restrictive lung disease (HP:0002091)2.09806080
95Recurrent otitis media (HP:0000403)2.09244664
96Pulmonary infiltrates (HP:0002113)2.09080031
97Verrucae (HP:0200043)2.07416583
98Papilloma (HP:0012740)2.07416583
99Chest pain (HP:0100749)2.07353509
100Glomerulopathy (HP:0100820)2.06462500
101Sepsis (HP:0100806)2.06008918
102Cellulitis (HP:0100658)2.02955454
103Keratoconjunctivitis sicca (HP:0001097)2.02546806
104Gingivitis (HP:0000230)2.01597083
105Ureteral stenosis (HP:0000071)2.01360929
106Slow saccadic eye movements (HP:0000514)2.00014019
107Amaurosis fugax (HP:0100576)1.99731598
108Increased serum ferritin (HP:0003281)1.99548886
109Skin ulcer (HP:0200042)1.98975778
110Abnormality of the prostate (HP:0008775)1.98556560
111Keratoconjunctivitis (HP:0001096)1.98473584
112Abnormality of cells of the erythroid lineage (HP:0012130)1.97873520
113Papilledema (HP:0001085)1.97873445
114Reticulocytopenia (HP:0001896)1.97586859
115Acute hepatic failure (HP:0006554)1.97517308
116Abnormality of macrophages (HP:0004311)1.97440135
117Neutropenia (HP:0001875)1.96742426
118Abnormal number of erythroid precursors (HP:0012131)1.96671680
119Purpura (HP:0000979)1.96325030
120Polyneuropathy (HP:0001271)1.95823149
121Ureteral obstruction (HP:0006000)1.95135615
122Arthralgia (HP:0002829)1.93074817

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.22445680
2TXK4.62310027
3JAK33.27377111
4ZAP703.03007855
5IKBKE3.01120562
6FGFR42.95474683
7NLK2.67376582
8ITK2.58625115
9TYK22.54326263
10MAP3K142.45142382
11TEC2.27732144
12PRPF4B2.16353897
13TBK12.09623005
14IRAK42.07628354
15BTK2.02809786
16JAK12.00368426
17BLK1.91840492
18FGFR31.87486862
19GRK61.83066699
20STK101.80224142
21LCK1.68123240
22KIT1.67688997
23NME21.63455133
24SYK1.51169183
25TESK21.49985303
26CSK1.48494414
27MST41.47920326
28FLT31.37896922
29KDR1.31088406
30EEF2K1.24486846
31IKBKB1.24112750
32FGR1.22719461
33HCK1.21863115
34MAP3K131.19927276
35TGFBR21.19056889
36BMPR21.17603168
37CAMKK21.17302920
38ERN11.15061552
39LRRK21.09678432
40TGFBR11.09421576
41PKN21.04855234
42IRAK31.04778049
43ACVR1B0.97716500
44CHUK0.94854885
45PASK0.93400574
46MAP2K30.89795833
47JAK20.88281267
48LYN0.87977150
49TNK20.87971926
50EPHA30.87796622
51RPS6KA40.87429136
52MATK0.86919137
53TAOK30.86706258
54MAP3K10.85260386
55CAMKK10.84421459
56PRKCQ0.83579661
57CSF1R0.81933141
58HIPK20.81288042
59TAOK20.80890835
60MAP2K60.77298857
61GRK70.76235997
62MAP3K100.76229673
63MAP3K30.75492379
64EPHB10.75159545
65PIM10.74582818
66CLK10.72209211
67RPS6KB20.67014543
68PRKCH0.65859588
69MAP3K70.65134732
70BCKDK0.63994087
71IRAK10.61001856
72MARK30.60528533
73CDC42BPA0.59858223
74SIK20.57887240
75RIPK40.57876513
76SIK10.56975785
77FES0.55816420
78SCYL20.54635119
79TYRO30.53555978
80PIK3CG0.52546289
81MAP3K120.52028411
82MAPK110.50956441
83SMG10.50497578
84MAPK70.49717063
85SIK30.49250524
86MAPK120.48324603
87FGFR20.47699385
88PRKG20.47033459
89MARK20.46533537
90PDPK10.45798947
91TNIK0.44387429
92PDGFRB0.43615172
93TRPM70.42373373
94CDK90.40013569
95STK40.39575340
96TRIB30.39387120
97TESK10.37857568
98IGF1R0.36434676
99NEK90.36174420
100NEK60.35552795
101PDK10.35081953
102PTK60.34509473
103KSR20.33606162
104MAPK30.33263236
105MAP3K110.32865988
106FRK0.32782925
107MAP3K50.31938844
108MAP2K20.31588346
109TAOK10.30896139
110CDK60.30723768
111CDK40.30527939
112YES10.30123182
113RPS6KL10.29961805
114RPS6KC10.29961805
115TLK10.29457855
116EIF2AK30.28773140
117MELK0.28455777
118MAPK40.28185085
119MAPKAPK20.27940479
120PRKD20.27737778
121CDK120.27239485
122RET0.25773090
123FYN0.23837682
124NUAK10.22913797
125RPS6KA60.22239172
126PRKCD0.21042515
127INSR0.20397870
128TIE10.19646396
129ABL10.18031931

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.72051282
2T cell receptor signaling pathway_Homo sapiens_hsa046603.10884182
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.77371505
4Measles_Homo sapiens_hsa051622.77342751
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.75868204
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.74116285
7Hematopoietic cell lineage_Homo sapiens_hsa046402.49912854
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.40641020
9Antigen processing and presentation_Homo sapiens_hsa046122.39493464
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.25749263
11Leishmaniasis_Homo sapiens_hsa051402.24873724
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.13986930
13B cell receptor signaling pathway_Homo sapiens_hsa046622.00567086
14Allograft rejection_Homo sapiens_hsa053301.99774307
15Ribosome_Homo sapiens_hsa030101.95994213
16Graft-versus-host disease_Homo sapiens_hsa053321.90161726
17Jak-STAT signaling pathway_Homo sapiens_hsa046301.87362192
18Herpes simplex infection_Homo sapiens_hsa051681.81616418
19Osteoclast differentiation_Homo sapiens_hsa043801.77305748
20Caffeine metabolism_Homo sapiens_hsa002321.52320159
21Influenza A_Homo sapiens_hsa051641.34124638
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.30585945
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.29925828
24Acute myeloid leukemia_Homo sapiens_hsa052211.28484696
25Autoimmune thyroid disease_Homo sapiens_hsa053201.28158265
26Leukocyte transendothelial migration_Homo sapiens_hsa046701.27465095
27Toxoplasmosis_Homo sapiens_hsa051451.22749262
28Hepatitis B_Homo sapiens_hsa051611.17331858
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.16526172
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.13763740
31Viral myocarditis_Homo sapiens_hsa054161.11171464
32TNF signaling pathway_Homo sapiens_hsa046681.10816293
33Protein export_Homo sapiens_hsa030601.08651608
34Hepatitis C_Homo sapiens_hsa051601.05963027
35Chemokine signaling pathway_Homo sapiens_hsa040621.05854708
36Legionellosis_Homo sapiens_hsa051341.03163026
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.02690673
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.99350653
39Apoptosis_Homo sapiens_hsa042100.98486358
40DNA replication_Homo sapiens_hsa030300.96360583
41Staphylococcus aureus infection_Homo sapiens_hsa051500.93900816
42Shigellosis_Homo sapiens_hsa051310.92964733
43Platelet activation_Homo sapiens_hsa046110.92254391
44Other glycan degradation_Homo sapiens_hsa005110.92096512
45Type I diabetes mellitus_Homo sapiens_hsa049400.91336766
46African trypanosomiasis_Homo sapiens_hsa051430.88463196
47Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85905770
48Phagosome_Homo sapiens_hsa041450.85784812
49HTLV-I infection_Homo sapiens_hsa051660.85338659
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84642118
51Base excision repair_Homo sapiens_hsa034100.84179259
52Asthma_Homo sapiens_hsa053100.81409103
53Pertussis_Homo sapiens_hsa051330.81139009
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80842739
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80503597
56Lysosome_Homo sapiens_hsa041420.78823677
57Prolactin signaling pathway_Homo sapiens_hsa049170.78698245
58Malaria_Homo sapiens_hsa051440.78335731
59Epstein-Barr virus infection_Homo sapiens_hsa051690.76451108
60Mismatch repair_Homo sapiens_hsa034300.75830474
61Pancreatic cancer_Homo sapiens_hsa052120.73980049
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72219516
63Tuberculosis_Homo sapiens_hsa051520.69466542
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68278240
65Thyroid cancer_Homo sapiens_hsa052160.66831222
66ABC transporters_Homo sapiens_hsa020100.65642148
67Non-homologous end-joining_Homo sapiens_hsa034500.65299811
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61666735
69p53 signaling pathway_Homo sapiens_hsa041150.60532936
70Endocytosis_Homo sapiens_hsa041440.58782178
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57845622
72Viral carcinogenesis_Homo sapiens_hsa052030.57547582
73RNA degradation_Homo sapiens_hsa030180.56275655
74Chronic myeloid leukemia_Homo sapiens_hsa052200.56094284
75N-Glycan biosynthesis_Homo sapiens_hsa005100.55245585
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.55047834
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.54804074
78Selenocompound metabolism_Homo sapiens_hsa004500.53917485
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.52923682
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52481269
81Galactose metabolism_Homo sapiens_hsa000520.51686547
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51003207
83AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50521834
84Spliceosome_Homo sapiens_hsa030400.49792460
85Notch signaling pathway_Homo sapiens_hsa043300.48773260
86Folate biosynthesis_Homo sapiens_hsa007900.48297427
87Pyrimidine metabolism_Homo sapiens_hsa002400.48005551
88Salmonella infection_Homo sapiens_hsa051320.47726696
89Homologous recombination_Homo sapiens_hsa034400.47638038
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47542432
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.45606410
92Nucleotide excision repair_Homo sapiens_hsa034200.44706478
93Renal cell carcinoma_Homo sapiens_hsa052110.44456306
94Insulin resistance_Homo sapiens_hsa049310.44039259
95FoxO signaling pathway_Homo sapiens_hsa040680.43862106
96Sulfur relay system_Homo sapiens_hsa041220.41730942
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41124443
98Inositol phosphate metabolism_Homo sapiens_hsa005620.40509578
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.39801299
100Choline metabolism in cancer_Homo sapiens_hsa052310.39358610
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38817511
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38664680
103Colorectal cancer_Homo sapiens_hsa052100.38083395
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37698365
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.37603032
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37592370
107Endometrial cancer_Homo sapiens_hsa052130.33761080
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33444867
109Non-small cell lung cancer_Homo sapiens_hsa052230.32390623
110Small cell lung cancer_Homo sapiens_hsa052220.31672086
111Rheumatoid arthritis_Homo sapiens_hsa053230.30879250
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30691653
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.30669373
114VEGF signaling pathway_Homo sapiens_hsa043700.30070971
115Pentose phosphate pathway_Homo sapiens_hsa000300.29774798
116Cyanoamino acid metabolism_Homo sapiens_hsa004600.29106690
117Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28613907
118MAPK signaling pathway_Homo sapiens_hsa040100.28171134
119Dorso-ventral axis formation_Homo sapiens_hsa043200.27380079
120Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.27207257
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.26876681
122mTOR signaling pathway_Homo sapiens_hsa041500.26534042
123Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.26003527
124Regulation of autophagy_Homo sapiens_hsa041400.24663131
125HIF-1 signaling pathway_Homo sapiens_hsa040660.23048356
126Systemic lupus erythematosus_Homo sapiens_hsa053220.22689652
127GnRH signaling pathway_Homo sapiens_hsa049120.21895049
128Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.21119120
129alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20430204
130Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20361743
131Prostate cancer_Homo sapiens_hsa052150.19300274
132Amoebiasis_Homo sapiens_hsa051460.17742020
133Type II diabetes mellitus_Homo sapiens_hsa049300.17591678

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