

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | antigen processing and presentation of endogenous antigen (GO:0019883) | 6.56346815 |
| 2 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 6.05118361 |
| 3 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 6.05118361 |
| 4 | modulation by symbiont of host immune response (GO:0052553) | 6.05118361 |
| 5 | positive regulation by symbiont of host defense response (GO:0052509) | 6.05118361 |
| 6 | modulation by symbiont of host defense response (GO:0052031) | 6.05118361 |
| 7 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 6.05118361 |
| 8 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 6.02864968 |
| 9 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 6.02864968 |
| 10 | positive regulation of gamma-delta T cell activation (GO:0046645) | 5.28640319 |
| 11 | detection of molecule of bacterial origin (GO:0032490) | 4.79548278 |
| 12 | microglial cell activation (GO:0001774) | 4.66597967 |
| 13 | detection of other organism (GO:0098543) | 4.65652757 |
| 14 | regulation of gamma-delta T cell differentiation (GO:0045586) | 4.64761528 |
| 15 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 4.55887349 |
| 16 | negative regulation of interleukin-12 production (GO:0032695) | 4.38912239 |
| 17 | B cell receptor signaling pathway (GO:0050853) | 4.37273437 |
| 18 | detection of external biotic stimulus (GO:0098581) | 4.36972386 |
| 19 | detection of bacterium (GO:0016045) | 4.36732137 |
| 20 | regulation of gamma-delta T cell activation (GO:0046643) | 4.32732401 |
| 21 | surfactant homeostasis (GO:0043129) | 4.29308293 |
| 22 | response to host immune response (GO:0052572) | 4.28388550 |
| 23 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 4.28388550 |
| 24 | cellular response to zinc ion (GO:0071294) | 4.25209399 |
| 25 | macrophage activation (GO:0042116) | 4.12502981 |
| 26 | endothelial tube morphogenesis (GO:0061154) | 4.09704150 |
| 27 | morphogenesis of an endothelium (GO:0003159) | 4.09704150 |
| 28 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 4.00508219 |
| 29 | response to host (GO:0075136) | 4.00508219 |
| 30 | response to host defenses (GO:0052200) | 4.00508219 |
| 31 | regulation of B cell receptor signaling pathway (GO:0050855) | 3.99310097 |
| 32 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 3.92708220 |
| 33 | regulation of B cell differentiation (GO:0045577) | 3.90747114 |
| 34 | detection of biotic stimulus (GO:0009595) | 3.87610365 |
| 35 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 3.86870747 |
| 36 | myeloid cell activation involved in immune response (GO:0002275) | 3.82289468 |
| 37 | positive regulation of B cell differentiation (GO:0045579) | 3.77178874 |
| 38 | neutrophil activation involved in immune response (GO:0002283) | 3.76498053 |
| 39 | regulation of myeloid leukocyte mediated immunity (GO:0002886) | 3.75800223 |
| 40 | NIK/NF-kappaB signaling (GO:0038061) | 3.74819297 |
| 41 | positive regulation of tumor necrosis factor biosynthetic process (GO:0042535) | 3.68794227 |
| 42 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 3.68241931 |
| 43 | lymph vessel development (GO:0001945) | 3.63022165 |
| 44 | neutrophil activation (GO:0042119) | 3.58565215 |
| 45 | negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515) | 3.57642960 |
| 46 | regulation of mast cell degranulation (GO:0043304) | 3.55444759 |
| 47 | negative regulation of T cell mediated immunity (GO:0002710) | 3.54796220 |
| 48 | negative regulation of leukocyte mediated immunity (GO:0002704) | 3.52444924 |
| 49 | JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397) | 3.46276821 |
| 50 | immunoglobulin mediated immune response (GO:0016064) | 3.42857499 |
| 51 | granulocyte activation (GO:0036230) | 3.39127663 |
| 52 | regulation of tumor necrosis factor biosynthetic process (GO:0042534) | 3.38290157 |
| 53 | vascular endothelial growth factor signaling pathway (GO:0038084) | 3.33932785 |
| 54 | leukocyte migration involved in inflammatory response (GO:0002523) | 3.32560284 |
| 55 | regulation of mast cell activation involved in immune response (GO:0033006) | 3.31185724 |
| 56 | positive regulation of myeloid leukocyte mediated immunity (GO:0002888) | 3.30187820 |
| 57 | regulation of leukocyte degranulation (GO:0043300) | 3.27622201 |
| 58 | positive regulation of mast cell activation (GO:0033005) | 3.27138257 |
| 59 | myeloid leukocyte mediated immunity (GO:0002444) | 3.25290534 |
| 60 | regulation of mast cell activation (GO:0033003) | 3.24761176 |
| 61 | mature B cell differentiation (GO:0002335) | 3.24386907 |
| 62 | regulation of interferon-beta biosynthetic process (GO:0045357) | 3.23328715 |
| 63 | antigen processing and presentation via MHC class Ib (GO:0002475) | 3.23025061 |
| 64 | negative regulation of T-helper cell differentiation (GO:0045623) | 3.20963589 |
| 65 | negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371) | 3.20963589 |
| 66 | response to type I interferon (GO:0034340) | 3.19463441 |
| 67 | positive thymic T cell selection (GO:0045059) | 3.18418702 |
| 68 | negative regulation of amyloid precursor protein catabolic process (GO:1902992) | 3.18010573 |
| 69 | production of molecular mediator involved in inflammatory response (GO:0002532) | 3.16417391 |
| 70 | respiratory burst (GO:0045730) | 3.13891889 |
| 71 | type I interferon signaling pathway (GO:0060337) | 3.12800140 |
| 72 | cellular response to type I interferon (GO:0071357) | 3.12800140 |
| 73 | defense response to protozoan (GO:0042832) | 3.07486719 |
| 74 | interferon-gamma-mediated signaling pathway (GO:0060333) | 3.07403972 |
| 75 | myeloid dendritic cell differentiation (GO:0043011) | 3.06286267 |
| 76 | chemical homeostasis within a tissue (GO:0048875) | 3.06019307 |
| 77 | cellular extravasation (GO:0045123) | 3.05521579 |
| 78 | positive regulation of interferon-alpha production (GO:0032727) | 3.02755692 |
| 79 | leukocyte degranulation (GO:0043299) | 2.98615395 |
| 80 | leukocyte aggregation (GO:0070486) | 2.96973863 |
| 81 | response to protozoan (GO:0001562) | 2.96603094 |
| 82 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 2.96273980 |
| 83 | regulation of T-helper 1 cell differentiation (GO:0045625) | 2.94779052 |
| 84 | regulation of T-helper 2 cell differentiation (GO:0045628) | 2.94471199 |
| 85 | negative regulation of interleukin-6 production (GO:0032715) | 2.93511599 |
| 86 | positive regulation of mast cell activation involved in immune response (GO:0033008) | 2.92407526 |
| 87 | positive regulation of mast cell degranulation (GO:0043306) | 2.92407526 |
| 88 | response to interleukin-15 (GO:0070672) | 2.88512766 |
| 89 | growth hormone receptor signaling pathway (GO:0060396) | 2.88453254 |
| 90 | regulation of interferon-alpha production (GO:0032647) | 2.88179238 |
| 91 | myeloid leukocyte activation (GO:0002274) | 2.87618677 |
| 92 | myeloid dendritic cell activation (GO:0001773) | 2.87166901 |
| 93 | positive regulation of antigen processing and presentation (GO:0002579) | 2.85428296 |
| 94 | lipopolysaccharide-mediated signaling pathway (GO:0031663) | 2.83541935 |
| 95 | regulation of regulated secretory pathway (GO:1903305) | 2.83140229 |
| 96 | negative regulation of adaptive immune response based on somatic recombination of immune receptors b | 2.82655425 |
| 97 | regulation of interleukin-6 biosynthetic process (GO:0045408) | 2.82049212 |
| 98 | response to muramyl dipeptide (GO:0032495) | 2.81762240 |
| 99 | positive regulation of natural killer cell differentiation (GO:0032825) | 2.81608845 |
| 100 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 2.80358610 |
| 101 | regulation of tolerance induction (GO:0002643) | 2.80170766 |
| 102 | positive regulation of cellular amide metabolic process (GO:0034250) | 2.77248753 |
| 103 | positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770) | 2.75661763 |
| 104 | neutrophil chemotaxis (GO:0030593) | 2.75224123 |
| 105 | negative regulation of cytokine production involved in immune response (GO:0002719) | 2.74563860 |
| 106 | natural killer cell differentiation (GO:0001779) | 2.74415751 |
| 107 | negative regulation of cell killing (GO:0031342) | 2.74196664 |
| 108 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 2.74196664 |
| 109 | negative regulation of phagocytosis (GO:0050765) | 2.73826976 |
| 110 | germinal center formation (GO:0002467) | 2.70495338 |
| 111 | establishment of endothelial barrier (GO:0061028) | 2.69824832 |
| 112 | regulation of B cell proliferation (GO:0030888) | 2.69228139 |
| 113 | positive regulation of interleukin-2 production (GO:0032743) | 2.68287860 |
| 114 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 2.68218488 |
| 115 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 2.67777528 |
| 116 | negative thymic T cell selection (GO:0045060) | 2.67413698 |
| 117 | mature B cell differentiation involved in immune response (GO:0002313) | 2.67354088 |
| 118 | cellular response to vascular endothelial growth factor stimulus (GO:0035924) | 2.66295003 |
| 119 | B cell mediated immunity (GO:0019724) | 2.65963967 |
| 120 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 2.64458096 |
| 121 | negative regulation of B cell proliferation (GO:0030889) | 2.62377310 |
| 122 | negative regulation of erythrocyte differentiation (GO:0045647) | 2.62268756 |
| 123 | response to peptidoglycan (GO:0032494) | 2.61416765 |
| 124 | negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665) | 2.60345894 |
| 125 | thymic T cell selection (GO:0045061) | 2.57672919 |
| 126 | leukocyte cell-cell adhesion (GO:0007159) | 2.57479662 |
| 127 | mucosal-associated lymphoid tissue development (GO:0048537) | 2.55628047 |
| 128 | Peyers patch development (GO:0048541) | 2.55628047 |
| 129 | lymph node development (GO:0048535) | 2.55146231 |
| 130 | B cell proliferation (GO:0042100) | 2.53815679 |
| 131 | macrophage activation involved in immune response (GO:0002281) | 2.52278577 |
| 132 | neutrophil mediated immunity (GO:0002446) | 2.50901668 |
| 133 | positive regulation of interleukin-12 production (GO:0032735) | 2.50146626 |
| 134 | cellular response to exogenous dsRNA (GO:0071360) | 2.49792000 |
| 135 | dendritic cell differentiation (GO:0097028) | 2.49497535 |
| 136 | T cell homeostasis (GO:0043029) | 2.49177592 |
| 137 | T-helper 1 type immune response (GO:0042088) | 2.48263705 |
| 138 | regulation of alpha-beta T cell proliferation (GO:0046640) | 2.47647573 |
| 139 | negative T cell selection (GO:0043383) | 2.46833670 |
| 140 | regulation of RIG-I signaling pathway (GO:0039535) | 2.46060080 |
| 141 | blood vessel maturation (GO:0001955) | 2.45618233 |
| 142 | T cell migration (GO:0072678) | 2.44962252 |
| 143 | lymphocyte homeostasis (GO:0002260) | 2.44374257 |
| 144 | natural killer cell mediated cytotoxicity (GO:0042267) | 2.43478000 |
| 145 | natural killer cell mediated immunity (GO:0002228) | 2.43478000 |
| 146 | megakaryocyte development (GO:0035855) | 2.43451185 |
| 147 | response to laminar fluid shear stress (GO:0034616) | 2.41531194 |
| 148 | positive regulation of histone deacetylation (GO:0031065) | 2.41132751 |
| 149 | cellular response to interleukin-15 (GO:0071350) | 2.40809870 |
| 150 | regulation of necroptotic process (GO:0060544) | 2.40412828 |
| 151 | positive regulation of B cell activation (GO:0050871) | 2.40096481 |
| 152 | positive regulation of humoral immune response (GO:0002922) | 2.39875062 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 5.87569477 |
| 2 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 4.09533168 |
| 3 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 3.88618396 |
| 4 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 3.82254103 |
| 5 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 3.68169278 |
| 6 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 3.61007522 |
| 7 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 3.30367016 |
| 8 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 3.25842011 |
| 9 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 3.11778453 |
| 10 | GATA1_22025678_ChIP-Seq_K562_Human | 3.08823435 |
| 11 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 2.95321420 |
| 12 | MYC_22102868_ChIP-Seq_BL_Human | 2.92816137 |
| 13 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.79162542 |
| 14 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.71016220 |
| 15 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.64841424 |
| 16 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 2.64495534 |
| 17 | SCL_19346495_ChIP-Seq_HPC-7_Human | 2.55338795 |
| 18 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.55198647 |
| 19 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.48555111 |
| 20 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 2.45239188 |
| 21 | * RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 2.42671277 |
| 22 | RUNX_20019798_ChIP-Seq_JUKART_Human | 2.30085499 |
| 23 | MAF_26560356_Chip-Seq_TH1_Human | 2.28223584 |
| 24 | * MYB_26560356_Chip-Seq_TH2_Human | 2.25291993 |
| 25 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 2.21252345 |
| 26 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 2.21088218 |
| 27 | * FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 2.17519960 |
| 28 | * E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 2.13563484 |
| 29 | * NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 2.09966897 |
| 30 | MYB_26560356_Chip-Seq_TH1_Human | 2.05113154 |
| 31 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.02350661 |
| 32 | * VDR_24763502_ChIP-Seq_THP-1_Human | 2.01491389 |
| 33 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.99633505 |
| 34 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.94657697 |
| 35 | * SPI1_23547873_ChIP-Seq_NB4_Human | 1.87736808 |
| 36 | UTX_26944678_Chip-Seq_JUKART_Human | 1.81821837 |
| 37 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.78737983 |
| 38 | * KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.75645219 |
| 39 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.75530281 |
| 40 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.69336813 |
| 41 | SPI1_23127762_ChIP-Seq_K562_Human | 1.63253769 |
| 42 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 1.61552877 |
| 43 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.60833188 |
| 44 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.57940473 |
| 45 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.48948223 |
| 46 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.48391926 |
| 47 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.47847857 |
| 48 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.47517671 |
| 49 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.44297316 |
| 50 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.42455340 |
| 51 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.42170003 |
| 52 | * GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.37645252 |
| 53 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.33634010 |
| 54 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.32872734 |
| 55 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.32410136 |
| 56 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.32232136 |
| 57 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.31016903 |
| 58 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.30801221 |
| 59 | MAF_26560356_Chip-Seq_TH2_Human | 1.29433031 |
| 60 | GATA1_19941826_ChIP-Seq_K562_Human | 1.29247571 |
| 61 | * GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.28836457 |
| 62 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.28142194 |
| 63 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.26000248 |
| 64 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.25731171 |
| 65 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.23469476 |
| 66 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 1.22804907 |
| 67 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.22530371 |
| 68 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.21297881 |
| 69 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.20904127 |
| 70 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.20888763 |
| 71 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.20683819 |
| 72 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.19387040 |
| 73 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.18741771 |
| 74 | NCOR1_26117541_ChIP-Seq_K562_Human | 1.18240443 |
| 75 | GATA2_19941826_ChIP-Seq_K562_Human | 1.12328318 |
| 76 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.11921140 |
| 77 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.11184232 |
| 78 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.10680969 |
| 79 | GATA3_26560356_Chip-Seq_TH2_Human | 1.09833898 |
| 80 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.09205671 |
| 81 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.08322795 |
| 82 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.07441597 |
| 83 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.05874578 |
| 84 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.04771664 |
| 85 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.03914216 |
| 86 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.01971055 |
| 87 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.01847954 |
| 88 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.01801118 |
| 89 | * LXR_22292898_ChIP-Seq_THP-1_Human | 1.00063132 |
| 90 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.98915899 |
| 91 | FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human | 0.98525669 |
| 92 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 0.98420553 |
| 93 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 0.97904113 |
| 94 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 0.97768155 |
| 95 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 0.97687259 |
| 96 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.96810113 |
| 97 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 0.96546317 |
| 98 | DROSHA_22980978_ChIP-Seq_HELA_Human | 0.94367565 |
| 99 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.93746139 |
| 100 | CDX2_20551321_ChIP-Seq_CACO-2_Human | 0.91689121 |
| 101 | * PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.90952185 |
| 102 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.90433915 |
| 103 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.89595530 |
| 104 | * FOXO3_23340844_ChIP-Seq_DLD1_Human | 0.88086244 |
| 105 | E2F7_22180533_ChIP-Seq_HELA_Human | 0.87884317 |
| 106 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 0.86827430 |
| 107 | * RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.86788223 |
| 108 | GATA1_19941827_ChIP-Seq_MEL86_Mouse | 0.85577774 |
| 109 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.83850699 |
| 110 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 0.83068771 |
| 111 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 0.82949522 |
| 112 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 0.82882820 |
| 113 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 0.82339202 |
| 114 | * BCL6_27268052_Chip-Seq_Bcells_Human | 0.81770709 |
| 115 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 0.81260397 |
| 116 | * KDM2B_26808549_Chip-Seq_K562_Human | 0.80690314 |
| 117 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 0.80656925 |
| 118 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 0.80656925 |
| 119 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.80526703 |
| 120 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.79623601 |
| 121 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 0.76920028 |
| 122 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.76588234 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0001835_abnormal_antigen_presentation | 4.00008036 |
| 2 | MP0005387_immune_system_phenotype | 3.17043097 |
| 3 | MP0001790_abnormal_immune_system | 3.17043097 |
| 4 | MP0000685_abnormal_immune_system | 3.04305606 |
| 5 | MP0003303_peritoneal_inflammation | 3.00838349 |
| 6 | MP0001800_abnormal_humoral_immune | 2.91772666 |
| 7 | MP0002138_abnormal_hepatobiliary_system | 2.88593174 |
| 8 | MP0009785_altered_susceptibility_to | 2.75554018 |
| 9 | MP0003724_increased_susceptibility_to | 2.70254631 |
| 10 | MP0001879_abnormal_lymphatic_vessel | 2.64942645 |
| 11 | MP0002452_abnormal_antigen_presenting | 2.54256527 |
| 12 | MP0005000_abnormal_immune_tolerance | 2.51368561 |
| 13 | MP0005671_abnormal_response_to | 2.44287909 |
| 14 | MP0003436_decreased_susceptibility_to | 2.35737427 |
| 15 | MP0002723_abnormal_immune_serum | 2.30902745 |
| 16 | MP0009278_abnormal_bone_marrow | 2.30312649 |
| 17 | MP0005167_abnormal_blood-brain_barrier | 2.26699389 |
| 18 | MP0005025_abnormal_response_to | 2.25573266 |
| 19 | MP0002420_abnormal_adaptive_immunity | 2.22961230 |
| 20 | MP0001819_abnormal_immune_cell | 2.21759723 |
| 21 | MP0003300_gastrointestinal_ulcer | 2.20342901 |
| 22 | MP0004510_myositis | 2.18726093 |
| 23 | MP0002166_altered_tumor_susceptibility | 2.18183357 |
| 24 | MP0002419_abnormal_innate_immunity | 2.15283154 |
| 25 | MP0002148_abnormal_hypersensitivity_rea | 2.14725457 |
| 26 | MP0010368_abnormal_lymphatic_system | 2.08623749 |
| 27 | MP0003172_abnormal_lysosome_physiology | 2.05171800 |
| 28 | MP0008260_abnormal_autophagy | 1.99788390 |
| 29 | MP0001873_stomach_inflammation | 1.87631047 |
| 30 | MP0002398_abnormal_bone_marrow | 1.85747787 |
| 31 | MP0010155_abnormal_intestine_physiology | 1.83379410 |
| 32 | MP0001545_abnormal_hematopoietic_system | 1.83172559 |
| 33 | MP0005397_hematopoietic_system_phenotyp | 1.83172559 |
| 34 | MP0000716_abnormal_immune_system | 1.81393644 |
| 35 | MP0005451_abnormal_body_composition | 1.74913984 |
| 36 | MP0001845_abnormal_inflammatory_respons | 1.73548096 |
| 37 | MP0002006_tumorigenesis | 1.72826415 |
| 38 | MP0002405_respiratory_system_inflammati | 1.66988876 |
| 39 | MP0004808_abnormal_hematopoietic_stem | 1.65171733 |
| 40 | MP0005464_abnormal_platelet_physiology | 1.62226227 |
| 41 | MP0001853_heart_inflammation | 1.58671485 |
| 42 | MP0000689_abnormal_spleen_morphology | 1.56547859 |
| 43 | MP0003828_pulmonary_edema | 1.56142452 |
| 44 | MP0010234_abnormal_vibrissa_follicle | 1.55911293 |
| 45 | MP0003763_abnormal_thymus_physiology | 1.55346389 |
| 46 | MP0004947_skin_inflammation | 1.53738727 |
| 47 | MP0002429_abnormal_blood_cell | 1.53477348 |
| 48 | MP0009764_decreased_sensitivity_to | 1.53031253 |
| 49 | MP0005310_abnormal_salivary_gland | 1.47957576 |
| 50 | MP0002722_abnormal_immune_system | 1.43118018 |
| 51 | MP0006054_spinal_hemorrhage | 1.36797950 |
| 52 | MP0001958_emphysema | 1.36626619 |
| 53 | MP0002396_abnormal_hematopoietic_system | 1.32699374 |
| 54 | MP0004782_abnormal_surfactant_physiolog | 1.30860671 |
| 55 | MP0002132_abnormal_respiratory_system | 1.28440535 |
| 56 | MP0008469_abnormal_protein_level | 1.28361654 |
| 57 | MP0010352_gastrointestinal_tract_polyps | 1.28198875 |
| 58 | MP0003690_abnormal_glial_cell | 1.28145035 |
| 59 | MP0003183_abnormal_peptide_metabolism | 1.27209869 |
| 60 | MP0003866_abnormal_defecation | 1.26706894 |
| 61 | MP0004381_abnormal_hair_follicle | 1.24711213 |
| 62 | MP0000569_abnormal_digit_pigmentation | 1.23742935 |
| 63 | MP0001986_abnormal_taste_sensitivity | 1.22611141 |
| 64 | MP0003191_abnormal_cellular_cholesterol | 1.21978967 |
| 65 | MP0002136_abnormal_kidney_physiology | 1.20887334 |
| 66 | MP0001533_abnormal_skeleton_physiology | 1.20860668 |
| 67 | MP0009333_abnormal_splenocyte_physiolog | 1.18539397 |
| 68 | MP0000343_altered_response_to | 1.14835504 |
| 69 | MP0005058_abnormal_lysosome_morphology | 1.13293712 |
| 70 | MP0000465_gastrointestinal_hemorrhage | 1.12795917 |
| 71 | MP0006082_CNS_inflammation | 1.11397671 |
| 72 | MP0003656_abnormal_erythrocyte_physiolo | 1.10127908 |
| 73 | MP0000767_abnormal_smooth_muscle | 1.09401775 |
| 74 | MP0000249_abnormal_blood_vessel | 1.09350233 |
| 75 | MP0003566_abnormal_cell_adhesion | 1.08559953 |
| 76 | MP0002933_joint_inflammation | 1.07924691 |
| 77 | MP0002877_abnormal_melanocyte_morpholog | 1.05692928 |
| 78 | MP0005166_decreased_susceptibility_to | 1.04454685 |
| 79 | MP0008004_abnormal_stomach_pH | 1.04390858 |
| 80 | MP0009643_abnormal_urine_homeostasis | 1.03638481 |
| 81 | MP0003448_altered_tumor_morphology | 1.01755651 |
| 82 | MP0008961_abnormal_basal_metabolism | 0.97311815 |
| 83 | MP0000703_abnormal_thymus_morphology | 0.96983835 |
| 84 | MP0002928_abnormal_bile_duct | 0.95864833 |
| 85 | MP0003091_abnormal_cell_migration | 0.94854629 |
| 86 | MP0003045_fibrosis | 0.93343336 |
| 87 | MP0002332_abnormal_exercise_endurance | 0.90155780 |
| 88 | MP0000858_altered_metastatic_potential | 0.88248122 |
| 89 | MP0000604_amyloidosis | 0.86578937 |
| 90 | MP0005164_abnormal_response_to | 0.84524227 |
| 91 | MP0003075_altered_response_to | 0.84389200 |
| 92 | MP0000015_abnormal_ear_pigmentation | 0.84028077 |
| 93 | MP0005390_skeleton_phenotype | 0.81480102 |
| 94 | MP0004130_abnormal_muscle_cell | 0.80199245 |
| 95 | MP0005360_urolithiasis | 0.79414354 |
| 96 | MP0005084_abnormal_gallbladder_morpholo | 0.77416442 |
| 97 | MP0002998_abnormal_bone_remodeling | 0.76469388 |
| 98 | MP0002277_abnormal_respiratory_mucosa | 0.76046261 |
| 99 | MP0003943_abnormal_hepatobiliary_system | 0.74924267 |
| 100 | MP0002009_preneoplasia | 0.73400428 |
| 101 | MP0000609_abnormal_liver_physiology | 0.71854851 |
| 102 | MP0005174_abnormal_tail_pigmentation | 0.71150700 |
| 103 | MP0001663_abnormal_digestive_system | 0.70324547 |
| 104 | MP0001851_eye_inflammation | 0.69459814 |
| 105 | MP0004883_abnormal_blood_vessel | 0.68596609 |
| 106 | MP0002254_reproductive_system_inflammat | 0.68319926 |
| 107 | MP0009763_increased_sensitivity_to | 0.68224733 |
| 108 | MP0002019_abnormal_tumor_incidence | 0.67193792 |
| 109 | MP0002693_abnormal_pancreas_physiology | 0.67007553 |
| 110 | MP0000490_abnormal_crypts_of | 0.66280289 |
| 111 | MP0005076_abnormal_cell_differentiation | 0.64829791 |
| 112 | MP0003279_aneurysm | 0.64341025 |
| 113 | MP0005075_abnormal_melanosome_morpholog | 0.63840251 |
| 114 | MP0003795_abnormal_bone_structure | 0.63580368 |
| 115 | MP0003221_abnormal_cardiomyocyte_apopto | 0.63251514 |
| 116 | MP0003453_abnormal_keratinocyte_physiol | 0.62604124 |
| 117 | MP0004264_abnormal_extraembryonic_tissu | 0.62215620 |
| 118 | MP0009765_abnormal_xenobiotic_induced | 0.62106303 |
| 119 | MP0008874_decreased_physiological_sensi | 0.61741443 |
| 120 | MP0002135_abnormal_kidney_morphology | 0.59884660 |
| 121 | MP0005319_abnormal_enzyme/_coenzyme | 0.58839264 |
| 122 | MP0003252_abnormal_bile_duct | 0.58672707 |
| 123 | MP0005388_respiratory_system_phenotype | 0.56566729 |
| 124 | MP0002133_abnormal_respiratory_system | 0.56566729 |
| 125 | MP0009115_abnormal_fat_cell | 0.56142481 |
| 126 | MP0004484_altered_response_of | 0.56046185 |
| 127 | MP0005376_homeostasis/metabolism_phenot | 0.49797451 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Agammaglobulinemia (HP:0004432) | 5.05150716 |
| 2 | Eczematoid dermatitis (HP:0000976) | 4.76023073 |
| 3 | Interstitial pulmonary disease (HP:0006530) | 4.59173877 |
| 4 | Colitis (HP:0002583) | 4.48988090 |
| 5 | Cellulitis (HP:0100658) | 4.45816510 |
| 6 | Hematochezia (HP:0002573) | 4.29778603 |
| 7 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 4.23361832 |
| 8 | Spontaneous hematomas (HP:0007420) | 4.20970884 |
| 9 | Recurrent bronchitis (HP:0002837) | 4.20353174 |
| 10 | Stomatitis (HP:0010280) | 4.18877624 |
| 11 | Recurrent abscess formation (HP:0002722) | 4.18724312 |
| 12 | Recurrent viral infections (HP:0004429) | 4.17736755 |
| 13 | Autoimmune thrombocytopenia (HP:0001973) | 4.17108214 |
| 14 | Gastrointestinal stroma tumor (HP:0100723) | 4.09568576 |
| 15 | Recurrent bacterial skin infections (HP:0005406) | 4.02043201 |
| 16 | Abnormality of the nasal mucosa (HP:0000433) | 4.01356567 |
| 17 | Inflammation of the large intestine (HP:0002037) | 3.92301874 |
| 18 | Polycythemia (HP:0001901) | 3.85341879 |
| 19 | Gastrointestinal inflammation (HP:0004386) | 3.84154079 |
| 20 | IgM deficiency (HP:0002850) | 3.81518898 |
| 21 | Gastrointestinal infarctions (HP:0005244) | 3.79817828 |
| 22 | Recurrent fungal infections (HP:0002841) | 3.74372472 |
| 23 | Chronic otitis media (HP:0000389) | 3.62230739 |
| 24 | Recurrent gram-negative bacterial infections (HP:0005420) | 3.52716873 |
| 25 | Keratoconjunctivitis sicca (HP:0001097) | 3.48638039 |
| 26 | Meningitis (HP:0001287) | 3.48208650 |
| 27 | Vasculitis (HP:0002633) | 3.44133183 |
| 28 | Myositis (HP:0100614) | 3.31979837 |
| 29 | Lymphopenia (HP:0001888) | 3.26659391 |
| 30 | Keratoconjunctivitis (HP:0001096) | 3.21973287 |
| 31 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 3.19622277 |
| 32 | Emphysema (HP:0002097) | 3.15303952 |
| 33 | Mediastinal lymphadenopathy (HP:0100721) | 3.13895380 |
| 34 | Osteomyelitis (HP:0002754) | 3.06386350 |
| 35 | Abnormality of macrophages (HP:0004311) | 3.03593352 |
| 36 | Abnormality of T cell physiology (HP:0011840) | 3.03402503 |
| 37 | Thrombocytosis (HP:0001894) | 3.02882334 |
| 38 | Elevated erythrocyte sedimentation rate (HP:0003565) | 3.02625266 |
| 39 | Panhypogammaglobulinemia (HP:0003139) | 3.00597951 |
| 40 | Chronic sinusitis (HP:0011109) | 2.93921874 |
| 41 | Bronchitis (HP:0012387) | 2.91498659 |
| 42 | IgA deficiency (HP:0002720) | 2.91275320 |
| 43 | Abnormality of T cells (HP:0002843) | 2.88683694 |
| 44 | Nasal polyposis (HP:0100582) | 2.88097569 |
| 45 | Recurrent skin infections (HP:0001581) | 2.87936421 |
| 46 | Recurrent sinusitis (HP:0011108) | 2.87051449 |
| 47 | Recurrent cutaneous fungal infections (HP:0011370) | 2.84903884 |
| 48 | Chronic mucocutaneous candidiasis (HP:0002728) | 2.84903884 |
| 49 | Papilloma (HP:0012740) | 2.81149454 |
| 50 | Verrucae (HP:0200043) | 2.81149454 |
| 51 | Hypochromic microcytic anemia (HP:0004840) | 2.75260074 |
| 52 | Abnormality of the fingertips (HP:0001211) | 2.75243479 |
| 53 | Peritonitis (HP:0002586) | 2.68621690 |
| 54 | Hypochromic anemia (HP:0001931) | 2.63472514 |
| 55 | Systemic lupus erythematosus (HP:0002725) | 2.61694337 |
| 56 | Orchitis (HP:0100796) | 2.60329402 |
| 57 | Fatigue (HP:0012378) | 2.59967715 |
| 58 | Episodic fever (HP:0001954) | 2.58561583 |
| 59 | Restrictive lung disease (HP:0002091) | 2.58308013 |
| 60 | Granulocytopenia (HP:0001913) | 2.53070744 |
| 61 | Esophageal varix (HP:0002040) | 2.50121926 |
| 62 | Amyloidosis (HP:0011034) | 2.48565029 |
| 63 | Recurrent lower respiratory tract infections (HP:0002783) | 2.48282843 |
| 64 | Arterial thrombosis (HP:0004420) | 2.44240950 |
| 65 | Pulmonary infiltrates (HP:0002113) | 2.43157322 |
| 66 | Chronic obstructive pulmonary disease (HP:0006510) | 2.41319325 |
| 67 | Obstructive lung disease (HP:0006536) | 2.41319325 |
| 68 | Viral hepatitis (HP:0006562) | 2.40337567 |
| 69 | Anorexia (HP:0002039) | 2.38402981 |
| 70 | Glomerulonephritis (HP:0000099) | 2.35091178 |
| 71 | Abnormality of T cell number (HP:0011839) | 2.33938355 |
| 72 | Recurrent pneumonia (HP:0006532) | 2.33032348 |
| 73 | B lymphocytopenia (HP:0010976) | 2.32691565 |
| 74 | Abnormality of B cell number (HP:0010975) | 2.32691565 |
| 75 | Hemoptysis (HP:0002105) | 2.30657904 |
| 76 | Gingivitis (HP:0000230) | 2.26150299 |
| 77 | Prolonged bleeding time (HP:0003010) | 2.26044227 |
| 78 | Thyroiditis (HP:0100646) | 2.25436841 |
| 79 | Optic neuritis (HP:0100653) | 2.24791035 |
| 80 | Retrobulbar optic neuritis (HP:0100654) | 2.24791035 |
| 81 | Pustule (HP:0200039) | 2.24141116 |
| 82 | Chest pain (HP:0100749) | 2.23925310 |
| 83 | Thoracic kyphosis (HP:0002942) | 2.23384162 |
| 84 | Abnormality of the endocardium (HP:0004306) | 2.22181816 |
| 85 | Sepsis (HP:0100806) | 2.20610483 |
| 86 | Abnormality of the peritoneum (HP:0002585) | 2.19755243 |
| 87 | Abnormality of the pleura (HP:0002103) | 2.19603791 |
| 88 | Impaired platelet aggregation (HP:0003540) | 2.18816684 |
| 89 | Abnormal platelet function (HP:0011869) | 2.18816684 |
| 90 | Vacuolated lymphocytes (HP:0001922) | 2.17602308 |
| 91 | Increased cerebral lipofuscin (HP:0011813) | 2.17069655 |
| 92 | Slow saccadic eye movements (HP:0000514) | 2.15223836 |
| 93 | Epistaxis (HP:0000421) | 2.15098459 |
| 94 | T lymphocytopenia (HP:0005403) | 2.13483275 |
| 95 | Encephalitis (HP:0002383) | 2.13255040 |
| 96 | Cheilitis (HP:0100825) | 2.12683930 |
| 97 | Increased IgE level (HP:0003212) | 2.12574118 |
| 98 | Gangrene (HP:0100758) | 2.06092888 |
| 99 | Periodontitis (HP:0000704) | 2.03967891 |
| 100 | Hyperactive renin-angiotensin system (HP:0000841) | 2.03806883 |
| 101 | Hypergammaglobulinemia (HP:0010702) | 2.01787795 |
| 102 | Skin ulcer (HP:0200042) | 2.01380643 |
| 103 | Microcytic anemia (HP:0001935) | 2.01183679 |
| 104 | Vertigo (HP:0002321) | 2.00949458 |
| 105 | Chronic diarrhea (HP:0002028) | 2.00026962 |
| 106 | Pulmonary embolism (HP:0002204) | 1.99871971 |
| 107 | Gingival bleeding (HP:0000225) | 1.98513301 |
| 108 | Urticaria (HP:0001025) | 1.97957038 |
| 109 | Increased IgM level (HP:0003496) | 1.94882548 |
| 110 | Glomerulopathy (HP:0100820) | 1.94629629 |
| 111 | Neutropenia (HP:0001875) | 1.94341241 |
| 112 | Petechiae (HP:0000967) | 1.92071528 |
| 113 | Abnormality of iron homeostasis (HP:0011031) | 1.89554758 |
| 114 | Abnormality of the thoracic spine (HP:0100711) | 1.86594873 |
| 115 | Difficulty running (HP:0009046) | 1.86084249 |
| 116 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 1.85501336 |
| 117 | Autoimmune hemolytic anemia (HP:0001890) | 1.84742800 |
| 118 | Abnormality of the vasculature of the conjunctiva (HP:0008054) | 1.83843573 |
| 119 | Keratitis (HP:0000491) | 1.83709033 |
| 120 | Abnormality of chloride homeostasis (HP:0011422) | 1.81754626 |
| 121 | Persistence of primary teeth (HP:0006335) | 1.80688349 |
| 122 | IgG deficiency (HP:0004315) | 1.80527334 |
| 123 | Loss of speech (HP:0002371) | 1.80086660 |
| 124 | Abnormality of eosinophils (HP:0001879) | 1.79540392 |
| 125 | Mucosal telangiectasiae (HP:0100579) | 1.78879677 |
| 126 | Arthralgia (HP:0002829) | 1.77281276 |
| 127 | Visceral angiomatosis (HP:0100761) | 1.77119440 |
| 128 | Myocardial infarction (HP:0001658) | 1.76638276 |
| 129 | Hemangiomatosis (HP:0007461) | 1.75807406 |
| 130 | Increased serum ferritin (HP:0003281) | 1.75239668 |
| 131 | Abnormality of the pericardium (HP:0001697) | 1.74891243 |
| 132 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 1.73261268 |
| 133 | Eosinophilia (HP:0001880) | 1.72487960 |
| 134 | Leukocytosis (HP:0001974) | 1.71542140 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MAP4K1 | 4.06832825 |
| 2 | TIE1 | 3.69376603 |
| 3 | ERN1 | 3.54264403 |
| 4 | KDR | 3.03666830 |
| 5 | MAP3K14 | 2.96569522 |
| 6 | TGFBR2 | 2.44711685 |
| 7 | RIPK4 | 2.31225551 |
| 8 | TYK2 | 2.30381589 |
| 9 | TBK1 | 2.27821691 |
| 10 | PRPF4B | 2.25572365 |
| 11 | JAK3 | 2.25071950 |
| 12 | TAOK3 | 2.24695375 |
| 13 | BLK | 2.19833640 |
| 14 | BTK | 2.02831980 |
| 15 | TNK2 | 2.00752034 |
| 16 | LRRK2 | 2.00637957 |
| 17 | EPHB1 | 1.94583537 |
| 18 | JAK1 | 1.90415335 |
| 19 | GRK6 | 1.82378653 |
| 20 | MAP3K10 | 1.81471271 |
| 21 | STK10 | 1.75624660 |
| 22 | CSK | 1.71684378 |
| 23 | IRAK4 | 1.70776974 |
| 24 | IRAK3 | 1.70605189 |
| 25 | KIT | 1.68739770 |
| 26 | TRIB3 | 1.54798800 |
| 27 | SYK | 1.54378427 |
| 28 | ZAP70 | 1.54292775 |
| 29 | IKBKB | 1.52849822 |
| 30 | TEC | 1.48199540 |
| 31 | IKBKE | 1.46833851 |
| 32 | CSF1R | 1.45888821 |
| 33 | TGFBR1 | 1.40773849 |
| 34 | PKN2 | 1.39659901 |
| 35 | TAOK1 | 1.38800755 |
| 36 | FRK | 1.38760759 |
| 37 | MAP3K13 | 1.38751867 |
| 38 | FGFR3 | 1.38656726 |
| 39 | FGFR4 | 1.37719453 |
| 40 | EEF2K | 1.29816130 |
| 41 | MAP3K11 | 1.25058010 |
| 42 | PTK6 | 1.22888101 |
| 43 | MARK2 | 1.22781142 |
| 44 | RIPK1 | 1.21849433 |
| 45 | IRAK1 | 1.19688401 |
| 46 | CHUK | 1.16194286 |
| 47 | MAP2K3 | 1.16049662 |
| 48 | HCK | 1.14463173 |
| 49 | SIK2 | 1.13417446 |
| 50 | MST4 | 1.12601608 |
| 51 | BMPR2 | 1.09349225 |
| 52 | ITK | 1.08381325 |
| 53 | KSR2 | 1.06938093 |
| 54 | EPHA3 | 1.05844373 |
| 55 | YES1 | 1.05314151 |
| 56 | MAP3K6 | 0.99777460 |
| 57 | PIK3CG | 0.98761189 |
| 58 | GRK1 | 0.98046904 |
| 59 | SIK1 | 0.97016139 |
| 60 | MATK | 0.96302356 |
| 61 | JAK2 | 0.96256295 |
| 62 | FLT3 | 0.95816098 |
| 63 | PIM1 | 0.94961183 |
| 64 | LYN | 0.94516483 |
| 65 | IRAK2 | 0.94479775 |
| 66 | MARK3 | 0.93998666 |
| 67 | CDC42BPA | 0.92833836 |
| 68 | RPS6KA4 | 0.85235677 |
| 69 | LCK | 0.85218748 |
| 70 | SIK3 | 0.84793686 |
| 71 | NLK | 0.78459211 |
| 72 | TAOK2 | 0.73540696 |
| 73 | CAMK1D | 0.72781685 |
| 74 | GRK7 | 0.72192725 |
| 75 | DYRK1B | 0.71365017 |
| 76 | SGK3 | 0.66456829 |
| 77 | TTN | 0.66164783 |
| 78 | SMG1 | 0.63453727 |
| 79 | INSRR | 0.62367245 |
| 80 | PRKCQ | 0.62271076 |
| 81 | ACVR1B | 0.61033066 |
| 82 | CDK12 | 0.60560237 |
| 83 | SGK2 | 0.60307141 |
| 84 | STK11 | 0.59507424 |
| 85 | MAP3K2 | 0.59418555 |
| 86 | STK4 | 0.58161970 |
| 87 | FYN | 0.57371503 |
| 88 | ABL1 | 0.55674063 |
| 89 | FES | 0.54994072 |
| 90 | WNK1 | 0.54072220 |
| 91 | PRKG2 | 0.53172150 |
| 92 | MAP3K5 | 0.53104792 |
| 93 | DAPK2 | 0.51180080 |
| 94 | RET | 0.50527544 |
| 95 | PRKCH | 0.49675629 |
| 96 | MAP2K4 | 0.49670793 |
| 97 | RPS6KC1 | 0.47834009 |
| 98 | RPS6KL1 | 0.47834009 |
| 99 | HIPK2 | 0.47386917 |
| 100 | MAP3K7 | 0.47097290 |
| 101 | CDK6 | 0.47008871 |
| 102 | TXK | 0.46999303 |
| 103 | MAP2K6 | 0.46904875 |
| 104 | PDK1 | 0.46310201 |
| 105 | PRKAA2 | 0.44937424 |
| 106 | MYLK | 0.44073574 |
| 107 | EGFR | 0.42309892 |
| 108 | RPS6KA6 | 0.42165664 |
| 109 | NEK9 | 0.41934409 |
| 110 | MOS | 0.41326126 |
| 111 | RPS6KB2 | 0.41090627 |
| 112 | CDK9 | 0.39773368 |
| 113 | MAP3K1 | 0.39502232 |
| 114 | MAPKAPK2 | 0.39356220 |
| 115 | RAF1 | 0.39255170 |
| 116 | PTK2B | 0.39168469 |
| 117 | FGR | 0.36510366 |
| 118 | STK38 | 0.35901866 |
| 119 | CAMK1G | 0.35279196 |
| 120 | MAPK12 | 0.34754329 |
| 121 | TRPM7 | 0.34716109 |
| 122 | PRKD2 | 0.34385883 |
| 123 | MAP3K3 | 0.33631537 |
| 124 | PDPK1 | 0.33435801 |
| 125 | MAP2K2 | 0.32720414 |
| 126 | BMX | 0.32565498 |
| 127 | MAP3K8 | 0.32430649 |
| 128 | MAPK7 | 0.31285689 |
| 129 | CAMK4 | 0.31067010 |
| 130 | PRKD1 | 0.30887247 |
| 131 | MAPK15 | 0.30592889 |
| 132 | MAPKAPK3 | 0.30290176 |
| 133 | CDK4 | 0.29739313 |
| 134 | PAK4 | 0.29573589 |
| 135 | STK24 | 0.29011299 |
| 136 | PRKCD | 0.27179842 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 3.36424180 |
| 2 | Primary immunodeficiency_Homo sapiens_hsa05340 | 3.34262405 |
| 3 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.98480920 |
| 4 | Leishmaniasis_Homo sapiens_hsa05140 | 2.89823084 |
| 5 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.64855150 |
| 6 | Osteoclast differentiation_Homo sapiens_hsa04380 | 2.35663905 |
| 7 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 2.05832954 |
| 8 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 2.03050766 |
| 9 | Measles_Homo sapiens_hsa05162 | 1.99462342 |
| 10 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.91255573 |
| 11 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.86950455 |
| 12 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.85640024 |
| 13 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.82703821 |
| 14 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.82091912 |
| 15 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.80667427 |
| 16 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.76883928 |
| 17 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.68582772 |
| 18 | Allograft rejection_Homo sapiens_hsa05330 | 1.64407254 |
| 19 | Influenza A_Homo sapiens_hsa05164 | 1.59838073 |
| 20 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.56528938 |
| 21 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 1.54076877 |
| 22 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.53671487 |
| 23 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.50015680 |
| 24 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.46751689 |
| 25 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.44463973 |
| 26 | Malaria_Homo sapiens_hsa05144 | 1.43256029 |
| 27 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.41876535 |
| 28 | Apoptosis_Homo sapiens_hsa04210 | 1.40209081 |
| 29 | Tuberculosis_Homo sapiens_hsa05152 | 1.38010162 |
| 30 | Legionellosis_Homo sapiens_hsa05134 | 1.37600655 |
| 31 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.37146952 |
| 32 | Pertussis_Homo sapiens_hsa05133 | 1.31113994 |
| 33 | Shigellosis_Homo sapiens_hsa05131 | 1.24871311 |
| 34 | African trypanosomiasis_Homo sapiens_hsa05143 | 1.23060575 |
| 35 | Phagosome_Homo sapiens_hsa04145 | 1.22334974 |
| 36 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.21471724 |
| 37 | Small cell lung cancer_Homo sapiens_hsa05222 | 1.21179646 |
| 38 | Viral myocarditis_Homo sapiens_hsa05416 | 1.19639202 |
| 39 | Platelet activation_Homo sapiens_hsa04611 | 1.19576401 |
| 40 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.18656588 |
| 41 | Hepatitis B_Homo sapiens_hsa05161 | 1.18109943 |
| 42 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.17987501 |
| 43 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.14730578 |
| 44 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.13725867 |
| 45 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 1.08343047 |
| 46 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.05330512 |
| 47 | Hepatitis C_Homo sapiens_hsa05160 | 1.02320501 |
| 48 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.00522072 |
| 49 | Salmonella infection_Homo sapiens_hsa05132 | 0.99689778 |
| 50 | Insulin resistance_Homo sapiens_hsa04931 | 0.98544601 |
| 51 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.94929918 |
| 52 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.93635029 |
| 53 | Asthma_Homo sapiens_hsa05310 | 0.93293135 |
| 54 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.92438713 |
| 55 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.90704527 |
| 56 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.87946842 |
| 57 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.86789668 |
| 58 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.86629353 |
| 59 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.84549849 |
| 60 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.83803667 |
| 61 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.83050730 |
| 62 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.74810218 |
| 63 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.74424811 |
| 64 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.73660242 |
| 65 | Other glycan degradation_Homo sapiens_hsa00511 | 0.73656272 |
| 66 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.73151683 |
| 67 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.73015365 |
| 68 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.71406722 |
| 69 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.71400154 |
| 70 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.70077851 |
| 71 | Amoebiasis_Homo sapiens_hsa05146 | 0.69810398 |
| 72 | HTLV-I infection_Homo sapiens_hsa05166 | 0.69433743 |
| 73 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.68961792 |
| 74 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.68742580 |
| 75 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.67997743 |
| 76 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.67844659 |
| 77 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.66616448 |
| 78 | Adherens junction_Homo sapiens_hsa04520 | 0.65864408 |
| 79 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.65734603 |
| 80 | Endocytosis_Homo sapiens_hsa04144 | 0.64134878 |
| 81 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.64078442 |
| 82 | Focal adhesion_Homo sapiens_hsa04510 | 0.63635843 |
| 83 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.63071165 |
| 84 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.62767015 |
| 85 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.61152665 |
| 86 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.60441482 |
| 87 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.59868972 |
| 88 | Endometrial cancer_Homo sapiens_hsa05213 | 0.58915654 |
| 89 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.58524084 |
| 90 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.57921245 |
| 91 | Lysosome_Homo sapiens_hsa04142 | 0.56807110 |
| 92 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.55736770 |
| 93 | ABC transporters_Homo sapiens_hsa02010 | 0.53695393 |
| 94 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.52586323 |
| 95 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.51788491 |
| 96 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.51754580 |
| 97 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.51038880 |
| 98 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.50162323 |
| 99 | Colorectal cancer_Homo sapiens_hsa05210 | 0.49283878 |
| 100 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.48408559 |
| 101 | Glioma_Homo sapiens_hsa05214 | 0.47938129 |
| 102 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.46998992 |
| 103 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.46125160 |
| 104 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.45884004 |
| 105 | Long-term potentiation_Homo sapiens_hsa04720 | 0.45630797 |
| 106 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.44256421 |
| 107 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.43818416 |
| 108 | Prostate cancer_Homo sapiens_hsa05215 | 0.43042140 |
| 109 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.41727992 |
| 110 | Pathways in cancer_Homo sapiens_hsa05200 | 0.40018117 |
| 111 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.39507809 |
| 112 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.39368018 |
| 113 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.38052559 |
| 114 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.35632246 |
| 115 | Lysine degradation_Homo sapiens_hsa00310 | 0.33784196 |
| 116 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.32983817 |
| 117 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.32483727 |
| 118 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.32202161 |
| 119 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.31676258 |
| 120 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.31281494 |
| 121 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.30839353 |
| 122 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.30820620 |

