DENND4A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a DENN domain-containing protein that may function as a guanine nucleotide exchange factor that specifically activates ras-related protein Rab-10. This protein also contains a interferon stimulated response element-binding domain and may be involved in regulating the v-myc avian myelocytomatosis viral (MYC) oncogene. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of granulocyte differentiation (GO:0030854)4.74221229
2positive regulation of gamma-delta T cell activation (GO:0046645)4.64210477
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.38798198
4negative regulation of cell killing (GO:0031342)4.38798198
5regulation of B cell receptor signaling pathway (GO:0050855)4.27634290
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.19734888
7mature B cell differentiation (GO:0002335)4.15552040
8antigen processing and presentation of endogenous antigen (GO:0019883)4.07914059
9regulation of interleukin-12 biosynthetic process (GO:0045075)3.98269395
10cellular response to ethanol (GO:0071361)3.94583366
11activated T cell proliferation (GO:0050798)3.85099532
12B cell receptor signaling pathway (GO:0050853)3.77156338
13phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.63191198
14positive regulation of B cell differentiation (GO:0045579)3.60458139
15positive thymic T cell selection (GO:0045059)3.59024405
16hepatocyte apoptotic process (GO:0097284)3.58545753
17negative thymic T cell selection (GO:0045060)3.55212187
18negative regulation of T-helper cell differentiation (GO:0045623)3.52470003
19negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.52470003
20CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.51267215
21regulation of gamma-delta T cell differentiation (GO:0045586)3.49983786
22regulation of ARF protein signal transduction (GO:0032012)3.48825438
23regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.44008692
24negative regulation of T cell mediated immunity (GO:0002710)3.41096820
25response to interleukin-15 (GO:0070672)3.40033191
26negative T cell selection (GO:0043383)3.39302350
27cellular response to interleukin-15 (GO:0071350)3.36849713
28antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.30866671
29antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.30866671
30regulation of gamma-delta T cell activation (GO:0046643)3.29525485
31regulation of interferon-beta biosynthetic process (GO:0045357)3.27023643
32JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.25802495
33tolerance induction (GO:0002507)3.23552464
34regulation of B cell differentiation (GO:0045577)3.16898864
35germinal center formation (GO:0002467)3.15028590
36NIK/NF-kappaB signaling (GO:0038061)3.13720906
37regulation of granulocyte differentiation (GO:0030852)3.12249352
38CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.08391346
39T-helper cell differentiation (GO:0042093)3.08391346
40negative regulation of granulocyte differentiation (GO:0030853)3.07526683
41negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.05092415
42B cell homeostasis (GO:0001782)3.04859410
43positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.04023007
44negative regulation of interleukin-12 production (GO:0032695)3.02520783
45monoubiquitinated protein deubiquitination (GO:0035520)3.01334892
46regulation of germinal center formation (GO:0002634)2.97276100
47positive regulation of alpha-beta T cell proliferation (GO:0046641)2.96520409
48myeloid dendritic cell differentiation (GO:0043011)2.96159743
49establishment of protein localization to Golgi (GO:0072600)2.94640964
50negative regulation of B cell proliferation (GO:0030889)2.92252479
51positive T cell selection (GO:0043368)2.89169664
52negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.89109030
53thymic T cell selection (GO:0045061)2.87596597
54regulation of isotype switching to IgG isotypes (GO:0048302)2.87568118
55macrophage activation involved in immune response (GO:0002281)2.85156160
56positive regulation of Rap GTPase activity (GO:0032854)2.84917968
57regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.83225431
58protoporphyrinogen IX metabolic process (GO:0046501)2.82071251
59modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.80921419
60positive regulation by organism of defense response of other organism involved in symbiotic interact2.80921419
61modulation by symbiont of host immune response (GO:0052553)2.80921419
62positive regulation by symbiont of host defense response (GO:0052509)2.80921419
63modulation by symbiont of host defense response (GO:0052031)2.80921419
64modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.80921419
65growth hormone receptor signaling pathway (GO:0060396)2.80691263
66negative regulation of B cell activation (GO:0050869)2.80192087
67regulation of T-helper 1 cell differentiation (GO:0045625)2.79873560
68myeloid dendritic cell activation (GO:0001773)2.79445072
69negative regulation of adaptive immune response (GO:0002820)2.78470447
70positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.78099520
71protein targeting to Golgi (GO:0000042)2.78091967
72mature B cell differentiation involved in immune response (GO:0002313)2.75203527
73microglial cell activation (GO:0001774)2.75049119
74alpha-beta T cell differentiation involved in immune response (GO:0002293)2.74796337
75alpha-beta T cell activation involved in immune response (GO:0002287)2.74796337
76T cell differentiation involved in immune response (GO:0002292)2.74796337
77histone H3-K36 demethylation (GO:0070544)2.74155180
78detection of molecule of bacterial origin (GO:0032490)2.73759478
79regulation of B cell activation (GO:0050864)2.73613003
80regulation of dendritic cell antigen processing and presentation (GO:0002604)2.70975759
81negative regulation of bone resorption (GO:0045779)2.69826864
82positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.69469605
83CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.69074228
84regulation of B cell proliferation (GO:0030888)2.68667114
85negative regulation of lymphocyte mediated immunity (GO:0002707)2.68577352
86regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.68411471
87negative regulation of alpha-beta T cell activation (GO:0046636)2.67739527
88positive regulation of immunoglobulin mediated immune response (GO:0002891)2.65863161
89positive regulation of B cell mediated immunity (GO:0002714)2.65863161
90regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.65319389
91regulation of alpha-beta T cell proliferation (GO:0046640)2.64275727
92lymphocyte homeostasis (GO:0002260)2.63200158
93positive regulation of interleukin-2 production (GO:0032743)2.62576319
94response to protozoan (GO:0001562)2.62401872
95retrograde transport, vesicle recycling within Golgi (GO:0000301)2.62013774
96T cell proliferation (GO:0042098)2.61766941
97neutrophil mediated immunity (GO:0002446)2.60958246
98necroptotic process (GO:0070266)2.60519226
99T cell selection (GO:0045058)2.60360913
100protein K11-linked deubiquitination (GO:0035871)2.58632106
101regulation of alpha-beta T cell activation (GO:0046634)2.57259236
102response to muramyl dipeptide (GO:0032495)2.56435491
103alpha-beta T cell activation (GO:0046631)2.56385498
104neutrophil activation (GO:0042119)2.55928724
105mast cell activation (GO:0045576)2.54917914
106cellular extravasation (GO:0045123)2.53604273
107regulation of Rap GTPase activity (GO:0032317)2.52280824
108positive regulation of histone deacetylation (GO:0031065)2.51408898
109regulation of B cell apoptotic process (GO:0002902)2.50233635
110cortical actin cytoskeleton organization (GO:0030866)2.50073478
111antigen receptor-mediated signaling pathway (GO:0050851)2.48632596
112cytoplasmic mRNA processing body assembly (GO:0033962)2.43812552
113interferon-gamma production (GO:0032609)2.43166069
114positive regulation of erythrocyte differentiation (GO:0045648)2.42991040
115granulocyte activation (GO:0036230)2.40641330
116positive regulation of B cell proliferation (GO:0030890)2.39539208
117B cell proliferation (GO:0042100)2.38727967
118T cell migration (GO:0072678)2.38406700
119histone H3-K4 trimethylation (GO:0080182)2.37766166
120negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.37012412
121leukocyte homeostasis (GO:0001776)2.36459396
122leukocyte aggregation (GO:0070486)2.36435863
123locomotory exploration behavior (GO:0035641)2.36348555
124T cell costimulation (GO:0031295)2.36054908
125negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.35564774
126defense response to protozoan (GO:0042832)2.35362713
127cellular response to growth hormone stimulus (GO:0071378)2.35251189
128regulation of T cell tolerance induction (GO:0002664)2.34403171
129negative regulation of toll-like receptor signaling pathway (GO:0034122)2.34032617
130interferon-gamma-mediated signaling pathway (GO:0060333)2.33441580
131lymphocyte costimulation (GO:0031294)2.32430712
132regulation of ARF GTPase activity (GO:0032312)2.31978868
133positive regulation of B cell activation (GO:0050871)2.30314511
134mononuclear cell proliferation (GO:0032943)2.29814258
135regulation of interferon-alpha production (GO:0032647)2.29697419
136lymph node development (GO:0048535)2.29464694
137leukocyte cell-cell adhesion (GO:0007159)2.28789238
138positive regulation of humoral immune response (GO:0002922)2.28407220
139positive regulation of interferon-alpha production (GO:0032727)2.28275090
140dendritic cell differentiation (GO:0097028)2.28041869
141lymphocyte proliferation (GO:0046651)2.27248400
142positive regulation of interleukin-12 production (GO:0032735)2.26596574
143positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.26141632
144erythrocyte maturation (GO:0043249)2.26132135
145response to methylmercury (GO:0051597)2.25205906
146regulation of erythrocyte differentiation (GO:0045646)2.25205233

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.06518221
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.62039437
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.64692156
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.21023575
5GATA1_22025678_ChIP-Seq_K562_Human3.16834205
6RUNX_20019798_ChIP-Seq_JUKART_Human3.02885726
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.88940799
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.81032818
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.78845532
10SCL_19346495_ChIP-Seq_HPC-7_Human2.70905846
11* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.69512980
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.66711211
13* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.57335847
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.56980657
15VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.37521418
16SMAD_19615063_ChIP-ChIP_OVARY_Human2.32495742
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.30710939
18MYC_22102868_ChIP-Seq_BL_Human2.29003266
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.26440522
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.22892905
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.13771728
22GATA1_19941826_ChIP-Seq_K562_Human2.08578805
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.00075913
24* TCF7_22412390_ChIP-Seq_EML_Mouse1.90532226
25TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.90259587
26* MYB_26560356_Chip-Seq_TH2_Human1.90178352
27Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.89679209
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.89070922
29GATA1_19941827_ChIP-Seq_MEL_Mouse1.82298481
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.82024790
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.81624821
32KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.79122880
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74908521
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.73250272
35MAF_26560356_Chip-Seq_TH1_Human1.72108210
36MYB_26560356_Chip-Seq_TH1_Human1.69861485
37VDR_21846776_ChIP-Seq_THP-1_Human1.67224272
38STAT4_19710469_ChIP-ChIP_TH1__Mouse1.62744165
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.62081848
40SPI1_23127762_ChIP-Seq_K562_Human1.61413678
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.61281221
42* KDM2B_26808549_Chip-Seq_DND41_Human1.58745258
43* GATA2_19941826_ChIP-Seq_K562_Human1.57195691
44* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.55565507
45BP1_19119308_ChIP-ChIP_Hs578T_Human1.55122498
46* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.53354922
47VDR_24787735_ChIP-Seq_THP-1_Human1.52992576
48VDR_24763502_ChIP-Seq_THP-1_Human1.52161463
49SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.52122633
50* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.43337320
51KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.41781822
52GATA3_27048872_Chip-Seq_THYMUS_Human1.41205616
53UTX_26944678_Chip-Seq_JUKART_Human1.39450896
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38920658
55* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33414681
56RUNX1_22412390_ChIP-Seq_EML_Mouse1.32986000
57PU_27001747_Chip-Seq_BMDM_Mouse1.25817894
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23612300
59CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23454738
60EZH2_27294783_Chip-Seq_NPCs_Mouse1.21905799
61TP53_16413492_ChIP-PET_HCT116_Human1.21753586
62GATA2_21666600_ChIP-Seq_HMVEC_Human1.21624459
63* KDM2B_26808549_Chip-Seq_JURKAT_Human1.20712612
64* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.19584977
65* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18065085
66STAT3_23295773_ChIP-Seq_U87_Human1.17405930
67EGR1_23403033_ChIP-Seq_LIVER_Mouse1.17254217
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15652533
69PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14676556
70RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.14563342
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14177399
72NFE2_27457419_Chip-Seq_LIVER_Mouse1.13870091
73IGF1R_20145208_ChIP-Seq_DFB_Human1.11784616
74PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11143864
75ZFP57_27257070_Chip-Seq_ESCs_Mouse1.11004601
76THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10803147
77FOXO3_23340844_ChIP-Seq_DLD1_Human1.09683857
78ER_23166858_ChIP-Seq_MCF-7_Human1.08990291
79AR_21572438_ChIP-Seq_LNCaP_Human1.08840064
80NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.07920571
81SMRT_27268052_Chip-Seq_Bcells_Human1.06943496
82TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06828250
83RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.05774270
84FLI1_21867929_ChIP-Seq_TH2_Mouse1.05715290
85OCT4_21477851_ChIP-Seq_ESCs_Mouse1.05622826
86PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05152049
87PRDM14_20953172_ChIP-Seq_ESCs_Human1.04629629
88NOTCH1_21737748_ChIP-Seq_TLL_Human1.04263665
89DROSHA_22980978_ChIP-Seq_HELA_Human1.03413268
90LXR_22158963_ChIP-Seq_LIVER_Mouse1.02836771
91PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01751083
92TAF15_26573619_Chip-Seq_HEK293_Human1.01545192
93IKZF1_21737484_ChIP-ChIP_HCT116_Human1.01523073
94NANOG_18555785_Chip-Seq_ESCs_Mouse1.01071750
95CRX_20693478_ChIP-Seq_RETINA_Mouse0.98851621
96ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98789414
97GBX2_23144817_ChIP-Seq_PC3_Human0.98751294
98TCF4_23295773_ChIP-Seq_U87_Human0.98381718
99* KDM2B_26808549_Chip-Seq_K562_Human0.97576805
100E2F1_18555785_Chip-Seq_ESCs_Mouse0.97157581
101SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97072065
102* FOXA2_19822575_ChIP-Seq_HepG2_Human0.95524235
103NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.95130972
104SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.94810562
105CMYC_18555785_Chip-Seq_ESCs_Mouse0.94489038
106MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93309066
107GATA3_26560356_Chip-Seq_TH1_Human0.93281763
108GATA3_26560356_Chip-Seq_TH2_Human0.92601897
109SALL4_22934838_ChIP-ChIP_CD34+_Human0.91648024
110CDX2_22108803_ChIP-Seq_LS180_Human0.91504116
111P53_22387025_ChIP-Seq_ESCs_Mouse0.91213086
112GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90699963
113ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.90082602
114STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89125841
115GATA2_22383799_ChIP-Seq_G1ME_Mouse0.88825526
116OCT4_18555785_Chip-Seq_ESCs_Mouse0.88493122
117NMYC_18555785_Chip-Seq_ESCs_Mouse0.88396903
118SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.87852602
119FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87729794
120EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86920060
121TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85339285
122CBP_20019798_ChIP-Seq_JUKART_Human0.85232937
123IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.85232937
124LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.85001515
125MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.84770197
126MAF_26560356_Chip-Seq_TH2_Human0.84553178
127SPI1_23547873_ChIP-Seq_NB4_Human0.84509768
128RARB_27405468_Chip-Seq_BRAIN_Mouse0.84379488
129BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82908871
130ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.82883417
131GATA1_22383799_ChIP-Seq_G1ME_Mouse0.82570545
132CTNNB1_20460455_ChIP-Seq_HCT116_Human0.81148460
133* RXR_22158963_ChIP-Seq_LIVER_Mouse0.77500504
134DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.76178846
135NFIB_24661679_ChIP-Seq_LUNG_Mouse0.75283294
136RXR_22108803_ChIP-Seq_LS180_Human0.74626743
137LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.73223225
138NR3C1_23031785_ChIP-Seq_PC12_Mouse0.73062494
139NCOR1_26117541_ChIP-Seq_K562_Human0.72612802
140ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.71056872
141* PPARA_22158963_ChIP-Seq_LIVER_Mouse0.69735599
142AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.69255300

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.55153792
2MP0003303_peritoneal_inflammation3.29902339
3MP0005671_abnormal_response_to3.27295316
4MP0001800_abnormal_humoral_immune3.10989012
5MP0005387_immune_system_phenotype3.10766478
6MP0001790_abnormal_immune_system3.10766478
7MP0003300_gastrointestinal_ulcer3.05322180
8MP0000685_abnormal_immune_system3.04467523
9MP0004510_myositis2.95807239
10MP0000569_abnormal_digit_pigmentation2.86258578
11MP0003656_abnormal_erythrocyte_physiolo2.62155328
12MP0005000_abnormal_immune_tolerance2.61265056
13MP0002452_abnormal_antigen_presenting2.51494566
14MP0003436_decreased_susceptibility_to2.37945637
15MP0002723_abnormal_immune_serum2.36118793
16MP0005464_abnormal_platelet_physiology2.33112668
17MP0002166_altered_tumor_susceptibility2.27526717
18MP0002420_abnormal_adaptive_immunity2.24411817
19MP0001819_abnormal_immune_cell2.21885832
20MP0002398_abnormal_bone_marrow2.14828748
21MP0002419_abnormal_innate_immunity2.09901344
22MP0002138_abnormal_hepatobiliary_system2.05469688
23MP0002254_reproductive_system_inflammat1.98420409
24MP0005025_abnormal_response_to1.94757283
25MP0000716_abnormal_immune_system1.89833574
26MP0003172_abnormal_lysosome_physiology1.88756130
27MP0006082_CNS_inflammation1.88629700
28MP0003195_calcinosis1.85165008
29MP0001873_stomach_inflammation1.80839803
30MP0002396_abnormal_hematopoietic_system1.75705441
31MP0002006_tumorigenesis1.75010950
32MP0000689_abnormal_spleen_morphology1.73075565
33MP0002148_abnormal_hypersensitivity_rea1.72788540
34MP0002405_respiratory_system_inflammati1.70054725
35MP0003763_abnormal_thymus_physiology1.69939426
36MP0001853_heart_inflammation1.68792252
37MP0003183_abnormal_peptide_metabolism1.66842781
38MP0004947_skin_inflammation1.65849284
39MP0005310_abnormal_salivary_gland1.64797020
40MP0000465_gastrointestinal_hemorrhage1.62346655
41MP0002722_abnormal_immune_system1.60469588
42MP0005076_abnormal_cell_differentiation1.58471125
43MP0002429_abnormal_blood_cell1.54811642
44MP0002877_abnormal_melanocyte_morpholog1.54398445
45MP0003787_abnormal_imprinting1.53751276
46MP0001845_abnormal_inflammatory_respons1.49148232
47MP0003045_fibrosis1.47160020
48MP0009785_altered_susceptibility_to1.46059100
49MP0005645_abnormal_hypothalamus_physiol1.44964280
50MP0000015_abnormal_ear_pigmentation1.41946124
51MP0000604_amyloidosis1.41901571
52MP0005451_abnormal_body_composition1.38930056
53MP0004381_abnormal_hair_follicle1.31732874
54MP0004859_abnormal_synaptic_plasticity1.31215406
55MP0000703_abnormal_thymus_morphology1.30856818
56MP0010155_abnormal_intestine_physiology1.29752827
57MP0004808_abnormal_hematopoietic_stem1.29038002
58MP0003191_abnormal_cellular_cholesterol1.28395104
59MP0005075_abnormal_melanosome_morpholog1.27234844
60MP0002163_abnormal_gland_morphology1.23349405
61MP0008961_abnormal_basal_metabolism1.23144733
62MP0010307_abnormal_tumor_latency1.22273245
63MP0001545_abnormal_hematopoietic_system1.21998976
64MP0005397_hematopoietic_system_phenotyp1.21998976
65MP0002928_abnormal_bile_duct1.19814917
66MP0001533_abnormal_skeleton_physiology1.19116167
67MP0008057_abnormal_DNA_replication1.18495721
68MP0001851_eye_inflammation1.17676269
69MP0005167_abnormal_blood-brain_barrier1.16722429
70MP0002009_preneoplasia1.15661630
71MP0003091_abnormal_cell_migration1.10418550
72MP0005379_endocrine/exocrine_gland_phen1.09418109
73MP0003075_altered_response_to1.08347248
74MP0008877_abnormal_DNA_methylation1.07478700
75MP0003690_abnormal_glial_cell1.05875001
76MP0003448_altered_tumor_morphology1.04809995
77MP0008469_abnormal_protein_level1.02471502
78MP0003866_abnormal_defecation1.00667930
79MP0002998_abnormal_bone_remodeling0.99342131
80MP0000371_diluted_coat_color0.97435466
81MP0004147_increased_porphyrin_level0.95371421
82MP0002693_abnormal_pancreas_physiology0.94931435
83MP0009764_decreased_sensitivity_to0.94302710
84MP0010352_gastrointestinal_tract_polyps0.94258233
85MP0000609_abnormal_liver_physiology0.94183975
86MP0003724_increased_susceptibility_to0.90840139
87MP0003252_abnormal_bile_duct0.90808721
88MP0002933_joint_inflammation0.90733870
89MP0002332_abnormal_exercise_endurance0.90475813
90MP0009333_abnormal_splenocyte_physiolog0.86488542
91MP0009278_abnormal_bone_marrow0.86442170
92MP0003828_pulmonary_edema0.86017967
93MP0008874_decreased_physiological_sensi0.81011094
94MP0003868_abnormal_feces_composition0.80984748
95MP0005058_abnormal_lysosome_morphology0.80056153
96MP0003453_abnormal_keratinocyte_physiol0.78194199
97MP0000249_abnormal_blood_vessel0.77602452
98MP0005166_decreased_susceptibility_to0.77001711
99MP0001348_abnormal_lacrimal_gland0.76773134
100MP0009763_increased_sensitivity_to0.76000351
101MP0008569_lethality_at_weaning0.75426168
102MP0008995_early_reproductive_senescence0.74339348
103MP0003646_muscle_fatigue0.73598243
104MP0004484_altered_response_of0.73525832
105MP0002139_abnormal_hepatobiliary_system0.73275106
106MP0004883_abnormal_blood_vessel0.72351976
107MP0002909_abnormal_adrenal_gland0.72305707
108MP0004130_abnormal_muscle_cell0.69531060
109MP0000920_abnormal_myelination0.69000200
110MP0001501_abnormal_sleep_pattern0.68697612
111MP0008872_abnormal_physiological_respon0.67005288
112MP0002876_abnormal_thyroid_physiology0.66909553
113MP0002168_other_aberrant_phenotype0.66674220
114MP0005164_abnormal_response_to0.65961748
115MP0003566_abnormal_cell_adhesion0.65787018
116MP0009115_abnormal_fat_cell0.63149923
117MP0005647_abnormal_sex_gland0.63109168
118MP0005266_abnormal_metabolism0.62811749
119MP0005174_abnormal_tail_pigmentation0.60242757
120MP0009765_abnormal_xenobiotic_induced0.58224407
121MP0002136_abnormal_kidney_physiology0.58175503
122MP0002019_abnormal_tumor_incidence0.58150431
123MP0003633_abnormal_nervous_system0.56522586
124MP0005621_abnormal_cell_physiology0.55553362
125MP0005584_abnormal_enzyme/coenzyme_acti0.51835183
126MP0008873_increased_physiological_sensi0.51144671

Predicted human phenotypes

RankGene SetZ-score
1Autoimmune hemolytic anemia (HP:0001890)4.04032043
2Agammaglobulinemia (HP:0004432)3.68663038
3Poikilocytosis (HP:0004447)3.63215153
4Eczematoid dermatitis (HP:0000976)3.57217846
5Hypochromic microcytic anemia (HP:0004840)3.53536898
6Colitis (HP:0002583)3.51306022
7Recurrent viral infections (HP:0004429)3.34087516
8Cellulitis (HP:0100658)3.31418147
9Recurrent fungal infections (HP:0002841)3.29013577
10Recurrent bacterial skin infections (HP:0005406)3.27387773
11Abnormality of the fingertips (HP:0001211)3.20739355
12Abnormal delayed hypersensitivity skin test (HP:0002963)3.19777268
13Recurrent abscess formation (HP:0002722)3.17706198
14Abnormality of T cell physiology (HP:0011840)3.10506945
15Acanthocytosis (HP:0001927)3.10416505
16Chronic mucocutaneous candidiasis (HP:0002728)2.98916991
17Recurrent cutaneous fungal infections (HP:0011370)2.98916991
18Elevated erythrocyte sedimentation rate (HP:0003565)2.97252101
19Inflammation of the large intestine (HP:0002037)2.90995533
20Vasculitis (HP:0002633)2.89161579
21Mediastinal lymphadenopathy (HP:0100721)2.85954142
22Pulmonary infiltrates (HP:0002113)2.85772645
23Recurrent gram-negative bacterial infections (HP:0005420)2.84730679
24Myocardial infarction (HP:0001658)2.84400185
25Gingival bleeding (HP:0000225)2.82328214
26Arterial thrombosis (HP:0004420)2.78604743
27Optic neuritis (HP:0100653)2.77657562
28Retrobulbar optic neuritis (HP:0100654)2.77657562
29Gastrointestinal inflammation (HP:0004386)2.74388228
30Verrucae (HP:0200043)2.73985882
31Papilloma (HP:0012740)2.73985882
32Meningitis (HP:0001287)2.72185774
33Recurrent skin infections (HP:0001581)2.71227034
34Gastrointestinal stroma tumor (HP:0100723)2.68497726
35Mitral stenosis (HP:0001718)2.61730262
36Neoplasm of the tracheobronchial system (HP:0100552)2.59644521
37Orchitis (HP:0100796)2.57487450
38Myositis (HP:0100614)2.56746168
39Fair hair (HP:0002286)2.55806724
40Hemoptysis (HP:0002105)2.49518690
41Abnormality of eosinophils (HP:0001879)2.48497624
42Macroorchidism (HP:0000053)2.48157403
43Papilledema (HP:0001085)2.46641135
44Systemic lupus erythematosus (HP:0002725)2.41381293
45Stomatitis (HP:0010280)2.39994902
46Recurrent bronchitis (HP:0002837)2.39636983
47Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.38343053
48Chronic otitis media (HP:0000389)2.36779119
49Eosinophilia (HP:0001880)2.36105719
50Prolonged bleeding time (HP:0003010)2.35551487
51Submucous cleft hard palate (HP:0000176)2.33912654
52Menstrual irregularities (HP:0000858)2.33689096
53IgM deficiency (HP:0002850)2.31188861
54Alveolar cell carcinoma (HP:0006519)2.31139385
55Recurrent sinusitis (HP:0011108)2.30729906
56Autoimmune thrombocytopenia (HP:0001973)2.29904588
57Aortic aneurysm (HP:0004942)2.29672955
58Microcytic anemia (HP:0001935)2.29437284
59Abnormality of the heme biosynthetic pathway (HP:0010472)2.29141770
60Abnormality of T cell number (HP:0011839)2.28478502
61Albinism (HP:0001022)2.28263380
62Panhypogammaglobulinemia (HP:0003139)2.27337034
63T lymphocytopenia (HP:0005403)2.26196767
64Generalized hypopigmentation of hair (HP:0011358)2.25863181
65Absent frontal sinuses (HP:0002688)2.25101112
66Genetic anticipation (HP:0003743)2.22571134
67Thyroiditis (HP:0100646)2.22477761
68Periodontitis (HP:0000704)2.21918630
69Chronic diarrhea (HP:0002028)2.20108621
70Abnormality of B cell number (HP:0010975)2.18896796
71Arterial tortuosity (HP:0005116)2.17948305
72Epistaxis (HP:0000421)2.17670716
73Osteomyelitis (HP:0002754)2.16442009
74Joint swelling (HP:0001386)2.15914251
75Emphysema (HP:0002097)2.15758549
76Lymphopenia (HP:0001888)2.15354819
77Severe combined immunodeficiency (HP:0004430)2.14502029
78Hematochezia (HP:0002573)2.13551708
79Gastrointestinal infarctions (HP:0005244)2.11682456
80Stomach cancer (HP:0012126)2.11538942
81Keratoconjunctivitis sicca (HP:0001097)2.09926102
82Encephalitis (HP:0002383)2.09774688
83Keratoconjunctivitis (HP:0001096)2.09665970
84Granulocytopenia (HP:0001913)2.09152729
85Hypochromic anemia (HP:0001931)2.08887930
86Hyperventilation (HP:0002883)2.08553163
87Spondylolisthesis (HP:0003302)2.07900199
88Anorexia (HP:0002039)2.07673073
89Gangrene (HP:0100758)2.06556469
90Gingivitis (HP:0000230)2.06330096
91Viral hepatitis (HP:0006562)2.06066927
92Abnormality of the pleura (HP:0002103)2.05940539
93Cerebral aneurysm (HP:0004944)2.05607547
94IgA deficiency (HP:0002720)2.03027714
95Increased CSF protein (HP:0002922)2.02083782
96Abnormality of cells of the lymphoid lineage (HP:0012140)2.01730054
97Nasal polyposis (HP:0100582)2.00649613
98Complement deficiency (HP:0004431)2.00617607
99Abnormal platelet function (HP:0011869)1.99254518
100Impaired platelet aggregation (HP:0003540)1.99254518
101Abnormality of the vasculature of the conjunctiva (HP:0008054)1.99028827
102Increased IgE level (HP:0003212)1.97563855
103Widely spaced teeth (HP:0000687)1.96086325
104Gaze-evoked nystagmus (HP:0000640)1.95832270
105Pulmonary embolism (HP:0002204)1.95743783
106Abnormality of macrophages (HP:0004311)1.95389706
107Hemiplegia (HP:0002301)1.94859098
108Striae distensae (HP:0001065)1.93681456
109Papillary thyroid carcinoma (HP:0002895)1.93119228
110Leukocytosis (HP:0001974)1.92218863
111Chronic obstructive pulmonary disease (HP:0006510)1.92076725
112Obstructive lung disease (HP:0006536)1.92076725
113Conjunctival telangiectasia (HP:0000524)1.91561951
114Vascular tortuosity (HP:0004948)1.91329127
115Chest pain (HP:0100749)1.90454997
116Fatigue (HP:0012378)1.90053909
117Spontaneous hematomas (HP:0007420)1.88510517
118Acute hepatic failure (HP:0006554)1.88400537
119Polyneuropathy (HP:0001271)1.88197710
120Acute myeloid leukemia (HP:0004808)1.86812546
121Keratitis (HP:0000491)1.86562054
122Restrictive lung disease (HP:0002091)1.83966807
123Osteolytic defects of the hand bones (HP:0009699)1.82737299
124Osteolytic defects of the phalanges of the hand (HP:0009771)1.82737299
125Mitral valve prolapse (HP:0001634)1.82053410
126Abnormal platelet volume (HP:0011876)1.79640245
127Heterotopia (HP:0002282)1.77681018
128Reticulocytosis (HP:0001923)1.77213642
129Pustule (HP:0200039)1.77017150
130Increased cerebral lipofuscin (HP:0011813)1.76346832
131Abnormality of T cells (HP:0002843)1.75934325
132Febrile seizures (HP:0002373)1.74097270
133Glomerulonephritis (HP:0000099)1.73623502
134IgG deficiency (HP:0004315)1.73404261

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.56697990
2MAP3K142.92551598
3MAP3K132.86196070
4RIPK42.74045728
5MST42.70961591
6JAK12.53944952
7GRK62.39496091
8TYK22.27977468
9BMPR22.15136873
10TGFBR22.07979432
11TXK2.07546277
12CDK122.03547887
13TAOK31.92222440
14CAMK1D1.88596737
15EPHB11.85105614
16IRAK31.79798563
17CAMK1G1.79574335
18SIK21.78850216
19JAK31.78652260
20IKBKB1.76171195
21FGFR31.70484785
22SYK1.68367148
23EPHA31.67774248
24MAP3K101.65488366
25ITK1.63754519
26EIF2AK31.59582322
27STK101.56783549
28IRAK11.55259157
29PIK3CG1.50571498
30HCK1.46568633
31CHUK1.43709823
32FES1.41717574
33TBK11.41376629
34AKT31.40863198
35EEF2K1.40002910
36IKBKE1.37753406
37CSF1R1.36909992
38IRAK41.33749013
39PRPF4B1.30850887
40NLK1.30596543
41FGFR41.30469075
42JAK21.25201785
43SGK31.19110335
44PIM11.16011185
45CSK1.14998766
46ERN11.14884554
47ACVR1B1.12619291
48MAPK111.11929226
49MAP2K31.11553542
50MAP3K71.06535733
51BTK1.06474359
52LCK0.98094043
53PDK20.96475108
54BRD40.96143931
55PRKCH0.93679716
56CDK90.93520812
57RIPK10.92106244
58PDGFRB0.92080073
59MAP3K90.91723071
60KIT0.91564858
61ZAP700.90619857
62PDK10.90392739
63BLK0.90111977
64TEC0.88977419
65SGK20.88255556
66PTK2B0.87669413
67LRRK20.86117232
68PRKCQ0.85443375
69DAPK20.85285957
70MAP2K60.85184330
71RET0.83177057
72ALK0.80535626
73EIF2AK10.79384664
74MELK0.78011836
75LYN0.77392181
76HIPK20.76572126
77STK40.75782869
78TAOK10.74392092
79CAMKK10.72537767
80MAPK70.71505470
81TRIB30.71125749
82MAPK120.67141421
83SIK10.67036548
84NEK60.66268818
85GRK70.65393576
86SCYL20.65084514
87SGK10.64364620
88ADRBK20.64304508
89SIK30.63296325
90WNK10.63265114
91MAP3K20.60077971
92PRKAA20.59977178
93STK110.59272671
94IRAK20.59237982
95CDK60.59115526
96PDPK10.58048356
97CLK10.57667184
98PKN10.55187675
99STK30.54667411
100MARK30.54040058
101MAP3K50.52161145
102CAMK40.51860386
103MAP3K10.51574041
104EGFR0.50152169
105KSR20.48548895
106PTK60.48171911
107BMX0.47585160
108FGR0.45384644
109PKN20.44778625
110TNK20.44291240
111SGK4940.44100128
112SGK2230.44100128
113TRPM70.43806886
114INSRR0.42769164
115CDK40.42247203
116FYN0.41353820
117PIK3CA0.39387706
118FGFR20.37693751
119PAK30.37545893
120CDK80.36979437
121MAP3K60.36266765
122ABL10.36021571
123STK240.35916882
124GRK50.35808656
125CDC42BPA0.35501181
126MATK0.35157608
127NEK90.34309530
128FRK0.34057761
129GSK3A0.33826838
130RPS6KA50.33631712
131CAMKK20.33570277

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046622.83491339
2Osteoclast differentiation_Homo sapiens_hsa043802.23395434
3NF-kappa B signaling pathway_Homo sapiens_hsa040641.95840120
4Primary immunodeficiency_Homo sapiens_hsa053401.93223848
5Staphylococcus aureus infection_Homo sapiens_hsa051501.92437159
6Leishmaniasis_Homo sapiens_hsa051401.91939040
7T cell receptor signaling pathway_Homo sapiens_hsa046601.69989211
8Intestinal immune network for IgA production_Homo sapiens_hsa046721.65646494
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.64582485
10Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.58257492
11Chemokine signaling pathway_Homo sapiens_hsa040621.56167054
12Graft-versus-host disease_Homo sapiens_hsa053321.55595619
13Allograft rejection_Homo sapiens_hsa053301.54512275
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.54476398
15Nitrogen metabolism_Homo sapiens_hsa009101.49722601
16Measles_Homo sapiens_hsa051621.44574182
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.43720483
18Hematopoietic cell lineage_Homo sapiens_hsa046401.36419004
19Type II diabetes mellitus_Homo sapiens_hsa049301.35588882
20Chronic myeloid leukemia_Homo sapiens_hsa052201.31754212
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.31451039
22Dorso-ventral axis formation_Homo sapiens_hsa043201.31234790
23Toxoplasmosis_Homo sapiens_hsa051451.26783481
24TNF signaling pathway_Homo sapiens_hsa046681.25214406
25Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.23739785
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.20670110
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.20378968
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.19564396
29Pancreatic cancer_Homo sapiens_hsa052121.19073672
30Tuberculosis_Homo sapiens_hsa051521.18452492
31Phosphatidylinositol signaling system_Homo sapiens_hsa040701.18373144
32Malaria_Homo sapiens_hsa051441.12239169
33Antigen processing and presentation_Homo sapiens_hsa046121.11326382
34Legionellosis_Homo sapiens_hsa051341.10739176
35Platelet activation_Homo sapiens_hsa046111.10051547
36Acute myeloid leukemia_Homo sapiens_hsa052211.08977619
37Neurotrophin signaling pathway_Homo sapiens_hsa047221.08931754
38Non-small cell lung cancer_Homo sapiens_hsa052231.07761903
39Hepatitis B_Homo sapiens_hsa051611.07020867
40Apoptosis_Homo sapiens_hsa042101.04988040
41Autoimmune thyroid disease_Homo sapiens_hsa053201.04902431
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.00116980
43Adipocytokine signaling pathway_Homo sapiens_hsa049200.97519843
44Complement and coagulation cascades_Homo sapiens_hsa046100.96201178
45Influenza A_Homo sapiens_hsa051640.95098365
46ABC transporters_Homo sapiens_hsa020100.94069211
47Prolactin signaling pathway_Homo sapiens_hsa049170.91300248
48Insulin resistance_Homo sapiens_hsa049310.91183991
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90199187
50Olfactory transduction_Homo sapiens_hsa047400.89552795
51mTOR signaling pathway_Homo sapiens_hsa041500.89498699
52Type I diabetes mellitus_Homo sapiens_hsa049400.89397770
53Rheumatoid arthritis_Homo sapiens_hsa053230.89385766
54Glioma_Homo sapiens_hsa052140.88795653
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87519486
56Pertussis_Homo sapiens_hsa051330.85955599
57Regulation of autophagy_Homo sapiens_hsa041400.85585928
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85023960
59Long-term potentiation_Homo sapiens_hsa047200.84273529
60MAPK signaling pathway_Homo sapiens_hsa040100.83687803
61FoxO signaling pathway_Homo sapiens_hsa040680.82813202
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82794731
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.82646403
64Circadian rhythm_Homo sapiens_hsa047100.80731468
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79366256
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.76568672
67Inositol phosphate metabolism_Homo sapiens_hsa005620.76188524
68Renal cell carcinoma_Homo sapiens_hsa052110.75294168
69African trypanosomiasis_Homo sapiens_hsa051430.75078925
70Herpes simplex infection_Homo sapiens_hsa051680.74555546
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.73463567
72Leukocyte transendothelial migration_Homo sapiens_hsa046700.73343247
73Viral myocarditis_Homo sapiens_hsa054160.72455625
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72319887
75Morphine addiction_Homo sapiens_hsa050320.70928366
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70776639
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70665365
78Lysine degradation_Homo sapiens_hsa003100.69504916
79Renin secretion_Homo sapiens_hsa049240.69411726
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68745391
81Hepatitis C_Homo sapiens_hsa051600.68487563
82Systemic lupus erythematosus_Homo sapiens_hsa053220.68061294
83Endocytosis_Homo sapiens_hsa041440.67523642
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67279083
85VEGF signaling pathway_Homo sapiens_hsa043700.66660716
86Prostate cancer_Homo sapiens_hsa052150.65243132
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64451888
88Choline metabolism in cancer_Homo sapiens_hsa052310.61989383
89Cholinergic synapse_Homo sapiens_hsa047250.61828346
90Oxytocin signaling pathway_Homo sapiens_hsa049210.61484050
91ErbB signaling pathway_Homo sapiens_hsa040120.60451624
92Viral carcinogenesis_Homo sapiens_hsa052030.60033033
93Estrogen signaling pathway_Homo sapiens_hsa049150.59845191
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59782968
95Salivary secretion_Homo sapiens_hsa049700.59679580
96Epstein-Barr virus infection_Homo sapiens_hsa051690.59494712
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59363071
98Shigellosis_Homo sapiens_hsa051310.58486303
99GnRH signaling pathway_Homo sapiens_hsa049120.57375037
100Glutamatergic synapse_Homo sapiens_hsa047240.55706332
101cAMP signaling pathway_Homo sapiens_hsa040240.53423704
102Glycosaminoglycan degradation_Homo sapiens_hsa005310.53397397
103MicroRNAs in cancer_Homo sapiens_hsa052060.52792074
104HIF-1 signaling pathway_Homo sapiens_hsa040660.52569707
105Circadian entrainment_Homo sapiens_hsa047130.52567216
106cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52465963
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.50940858
108Asthma_Homo sapiens_hsa053100.50614621
109Small cell lung cancer_Homo sapiens_hsa052220.49127775
110SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48693640
111Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47480681
112Colorectal cancer_Homo sapiens_hsa052100.46528832
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45557983
114Endometrial cancer_Homo sapiens_hsa052130.44703666
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38945268
116HTLV-I infection_Homo sapiens_hsa051660.36526504
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34911094
118Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34438699
119Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31893006
120Pancreatic secretion_Homo sapiens_hsa049720.27071129

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