DENND4C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)5.28741320
2COPI coating of Golgi vesicle (GO:0048205)5.28741320
3intestinal epithelial cell development (GO:0060576)4.53153751
4phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.17281999
5COPII vesicle coating (GO:0048208)4.11341751
6cellular response to ethanol (GO:0071361)3.91179999
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.86139567
8activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.84061350
9regulation of type B pancreatic cell apoptotic process (GO:2000674)3.79323823
10interkinetic nuclear migration (GO:0022027)3.71800972
11production of molecular mediator involved in inflammatory response (GO:0002532)3.70906327
12cellular ketone body metabolic process (GO:0046950)3.69518120
13positive regulation of nuclease activity (GO:0032075)3.65763611
14vitamin transmembrane transport (GO:0035461)3.54485320
15columnar/cuboidal epithelial cell development (GO:0002066)3.52258492
16regulation of pigment cell differentiation (GO:0050932)3.51806303
17regulation of guanylate cyclase activity (GO:0031282)3.51107277
18iron ion import (GO:0097286)3.49626239
19positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.46730659
20lipid translocation (GO:0034204)3.42228616
21phospholipid translocation (GO:0045332)3.42228616
22cellular zinc ion homeostasis (GO:0006882)3.41922858
23positive regulation of histone deacetylation (GO:0031065)3.41743839
24interleukin-6-mediated signaling pathway (GO:0070102)3.41567949
25positive regulation of p38MAPK cascade (GO:1900745)3.40383964
26L-alpha-amino acid transmembrane transport (GO:1902475)3.34055801
27regulation of nuclease activity (GO:0032069)3.33504741
28retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.31156408
29macroautophagy (GO:0016236)3.30689576
30sequestering of metal ion (GO:0051238)3.28735781
31cytoplasmic mRNA processing body assembly (GO:0033962)3.28546723
32endoplasmic reticulum unfolded protein response (GO:0030968)3.27212646
33Golgi to endosome transport (GO:0006895)3.26751126
34endocrine pancreas development (GO:0031018)3.24684554
35cytidine deamination (GO:0009972)3.24172347
36cytidine metabolic process (GO:0046087)3.24172347
37cytidine catabolic process (GO:0006216)3.24172347
38exocrine pancreas development (GO:0031017)3.20245353
39maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.17395223
40ketone body metabolic process (GO:1902224)3.16959887
41cellular response to unfolded protein (GO:0034620)3.16213803
42pyrimidine-containing compound transmembrane transport (GO:0072531)3.15448366
43type B pancreatic cell development (GO:0003323)3.13474202
44peptide hormone processing (GO:0016486)3.11820948
45bundle of His cell to Purkinje myocyte communication (GO:0086069)3.09083556
46ER-nucleus signaling pathway (GO:0006984)3.08987099
47vesicle coating (GO:0006901)3.03889824
48negative regulation of bone resorption (GO:0045779)3.00550280
49apoptotic cell clearance (GO:0043277)2.98471765
50glandular epithelial cell differentiation (GO:0002067)2.96676501
51positive regulation by organism of defense response of other organism involved in symbiotic interact2.95330061
52modulation by symbiont of host immune response (GO:0052553)2.95330061
53positive regulation by symbiont of host defense response (GO:0052509)2.95330061
54modulation by symbiont of host defense response (GO:0052031)2.95330061
55modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.95330061
56modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.95330061
57regulation of protein glycosylation (GO:0060049)2.92115723
58positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.91560776
59oligosaccharide catabolic process (GO:0009313)2.91452783
60negative regulation of neurotransmitter secretion (GO:0046929)2.91378442
61pyrimidine ribonucleoside catabolic process (GO:0046133)2.91151516
62cellular response to topologically incorrect protein (GO:0035967)2.89550335
63phospholipid homeostasis (GO:0055091)2.89046049
64positive regulation of developmental pigmentation (GO:0048087)2.87921210
65glandular epithelial cell development (GO:0002068)2.86848243
66intestinal cholesterol absorption (GO:0030299)2.86644899
67response to growth hormone (GO:0060416)2.84326656
68regulation of transforming growth factor beta2 production (GO:0032909)2.82725949
69definitive hemopoiesis (GO:0060216)2.80832990
70nucleus localization (GO:0051647)2.79994065
71intestinal absorption (GO:0050892)2.78503906
72positive regulation of glycolytic process (GO:0045821)2.77863597
73platelet-derived growth factor receptor signaling pathway (GO:0048008)2.76023955
74response to lipoprotein particle (GO:0055094)2.75842261
75lipoprotein transport (GO:0042953)2.74771003
76negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.72339100
77regulation of protein polyubiquitination (GO:1902914)2.70261607
78early endosome to late endosome transport (GO:0045022)2.70167210
79response to endoplasmic reticulum stress (GO:0034976)2.69805464
80prostate gland growth (GO:0060736)2.69147440
81regulation of interferon-beta biosynthetic process (GO:0045357)2.68778105
82gland morphogenesis (GO:0022612)2.67368747
83cellular response to vitamin D (GO:0071305)2.67246188
84zinc ion homeostasis (GO:0055069)2.66671592
85establishment of protein localization to vacuole (GO:0072666)2.66085883
86protein targeting to vacuole (GO:0006623)2.66085883
87protein targeting to lysosome (GO:0006622)2.66085883
88low-density lipoprotein particle clearance (GO:0034383)2.64579917
89fibroblast migration (GO:0010761)2.59954500
90retina vasculature morphogenesis in camera-type eye (GO:0061299)2.59677747
91cell wall macromolecule catabolic process (GO:0016998)2.59260255
92growth hormone receptor signaling pathway (GO:0060396)2.58547893
93glycoprotein catabolic process (GO:0006516)2.58445565
94glycosphingolipid catabolic process (GO:0046479)2.57777890
95UDP-N-acetylglucosamine metabolic process (GO:0006047)2.57168298
96protein targeting to Golgi (GO:0000042)2.56214241
97sphingosine metabolic process (GO:0006670)2.55574831
98regulation of T cell tolerance induction (GO:0002664)2.55450832
99retrograde transport, vesicle recycling within Golgi (GO:0000301)2.54969615
100hormone catabolic process (GO:0042447)2.54620057
101positive regulation of guanylate cyclase activity (GO:0031284)2.54179194
102snRNA transcription (GO:0009301)2.53004512
103regulation of macrophage derived foam cell differentiation (GO:0010743)2.52587259
104regulation of cholesterol homeostasis (GO:2000188)2.52344170
105hemidesmosome assembly (GO:0031581)2.51396274
106negative regulation of bone remodeling (GO:0046851)2.50252151
107cellular response to vitamin (GO:0071295)2.50007467
108establishment of protein localization to Golgi (GO:0072600)2.49319779
109Golgi organization (GO:0007030)2.48107495
110cellular response to thyroid hormone stimulus (GO:0097067)2.47802279
111regulation of cholesterol storage (GO:0010885)2.46311850
112protein retention in ER lumen (GO:0006621)2.46046272
113regulation of p38MAPK cascade (GO:1900744)2.45797398
114protein K48-linked deubiquitination (GO:0071108)2.45214299
115phospholipid efflux (GO:0033700)2.42374345
116protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.41851159
117desmosome organization (GO:0002934)2.40778673
118regulation of establishment of cell polarity (GO:2000114)2.40017616
119intracellular lipid transport (GO:0032365)2.39357856
120keratan sulfate catabolic process (GO:0042340)2.39266222
121embryonic process involved in female pregnancy (GO:0060136)2.39208728
122mannose metabolic process (GO:0006013)2.37835958
123negative regulation of complement activation (GO:0045916)2.37413045
124regulation of glycolytic process (GO:0006110)2.37081108
125positive regulation of cholesterol efflux (GO:0010875)2.35911677
126protein K11-linked deubiquitination (GO:0035871)2.35246422
127glycolipid catabolic process (GO:0019377)2.34362306
128nerve growth factor signaling pathway (GO:0038180)2.33722417
129regulation of membrane protein ectodomain proteolysis (GO:0051043)2.33698496
130labyrinthine layer development (GO:0060711)2.33214136
131lung lobe morphogenesis (GO:0060463)2.32827669
132sphingoid metabolic process (GO:0046519)2.31953819
133genitalia morphogenesis (GO:0035112)2.30499416
134monoubiquitinated protein deubiquitination (GO:0035520)2.29498188
135regulation of establishment or maintenance of cell polarity (GO:0032878)2.29172291
136response to unfolded protein (GO:0006986)2.29088945
137antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.27947321
138antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.27947321
139histone lysine demethylation (GO:0070076)2.27563054
140inner ear receptor cell development (GO:0060119)2.27091335
141diol metabolic process (GO:0034311)2.27059067
142coronary vasculature morphogenesis (GO:0060977)2.26734448
143negative regulation of lipid storage (GO:0010888)2.26651340
144auditory receptor cell differentiation (GO:0042491)2.26590457
145homocysteine metabolic process (GO:0050667)2.26469495
146establishment of nucleus localization (GO:0040023)2.25735789
147protein localization to Golgi apparatus (GO:0034067)2.25602236
148histone H3-K36 demethylation (GO:0070544)2.25202294
149positive regulation of sterol transport (GO:0032373)2.24782412
1504-hydroxyproline metabolic process (GO:0019471)2.24571799
151negative regulation of protein activation cascade (GO:2000258)2.24563494
152positive regulation of muscle hypertrophy (GO:0014742)2.23915544
153positive regulation of cardiac muscle hypertrophy (GO:0010613)2.23915544
154regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.23795567
155insulin-like growth factor receptor signaling pathway (GO:0048009)2.23645449
156cell adhesion mediated by integrin (GO:0033627)2.22998609
157zinc ion transmembrane transport (GO:0071577)2.22771835
158positive regulation of hormone biosynthetic process (GO:0046886)2.21870032
159ceramide catabolic process (GO:0046514)2.21763951
160positive regulation of cholesterol transport (GO:0032376)2.21455526
161histone H3-K4 trimethylation (GO:0080182)2.18916782
162nuclear pore complex assembly (GO:0051292)2.16599104
163intra-Golgi vesicle-mediated transport (GO:0006891)2.16217646
164regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.15812224
165positive regulation of glycoprotein biosynthetic process (GO:0010560)2.15122178
166positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.14465838
167histone H3-K9 demethylation (GO:0033169)2.14401833
168pathway-restricted SMAD protein phosphorylation (GO:0060389)2.14020984
169histone demethylation (GO:0016577)2.13326745
170thrombin receptor signaling pathway (GO:0070493)2.12394351
171peptidyl-lysine trimethylation (GO:0018023)2.11909173
172peptide catabolic process (GO:0043171)2.11354793
173regulation of steroid hormone biosynthetic process (GO:0090030)2.11352728
174positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.09915184
175carnitine shuttle (GO:0006853)2.08324218
176cell wall macromolecule metabolic process (GO:0044036)2.08287193
177positive regulation of bone resorption (GO:0045780)2.07470412
178positive regulation of bone remodeling (GO:0046852)2.07470412
179smooth muscle tissue development (GO:0048745)2.07022247
180fatty acid transmembrane transport (GO:1902001)2.06952535
181regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.06796263

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.65490364
2GATA1_22025678_ChIP-Seq_K562_Human3.15040372
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.12967962
4STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.12173701
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.90387807
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.88521711
7LXR_22158963_ChIP-Seq_LIVER_Mouse2.78318313
8RXR_22158963_ChIP-Seq_LIVER_Mouse2.66784340
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.65217984
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.52795724
11* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.51596472
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.46585752
13PPARA_22158963_ChIP-Seq_LIVER_Mouse2.42825578
14* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.30097986
15ESR1_21235772_ChIP-Seq_MCF-7_Human2.23076492
16FOXO3_23340844_ChIP-Seq_DLD1_Human2.19155970
17CLOCK_20551151_ChIP-Seq_293T_Human2.17481787
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.04191286
19* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.02000190
20PIAS1_25552417_ChIP-Seq_VCAP_Human1.95969917
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.95184825
22NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.89733384
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.85919790
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.85778822
25GATA2_21666600_ChIP-Seq_HMVEC_Human1.83933744
26STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.83189444
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80417129
28AHR_22903824_ChIP-Seq_MCF-7_Human1.74172145
29GBX2_23144817_ChIP-Seq_PC3_Human1.73404760
30PPAR_26484153_Chip-Seq_NCI-H1993_Human1.72056977
31IRF8_27001747_Chip-Seq_BMDM_Mouse1.70205684
32FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.69570230
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.68470053
34TAF15_26573619_Chip-Seq_HEK293_Human1.67191662
35TP53_16413492_ChIP-PET_HCT116_Human1.66454609
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.62509766
37ZNF217_24962896_ChIP-Seq_MCF-7_Human1.61623692
38SMAD4_21799915_ChIP-Seq_A2780_Human1.60929494
39GATA1_19941826_ChIP-Seq_K562_Human1.59266422
40FOXM1_26456572_ChIP-Seq_MCF-7_Human1.58969725
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.56866792
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.55977155
43KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.54980686
44GATA6_25053715_ChIP-Seq_YYC3_Human1.52330231
45ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.50766261
46MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50590266
47PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.48118083
48TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47147750
49STAT3_23295773_ChIP-Seq_U87_Human1.46622998
50BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.45882533
51SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45861813
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45566927
53CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.44897524
54BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.44703077
55FOXA2_19822575_ChIP-Seq_HepG2_Human1.43819986
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43011033
57GATA4_25053715_ChIP-Seq_YYC3_Human1.43004579
58* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.42096456
59TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.41840236
60IGF1R_20145208_ChIP-Seq_DFB_Human1.41586896
61FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.41514534
62IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.40544964
63SCL_19346495_ChIP-Seq_HPC-7_Human1.40133387
64CTNNB1_20460455_ChIP-Seq_HCT116_Human1.38919510
65BRD4_27068464_Chip-Seq_AML-cells_Mouse1.37714750
66* FUS_26573619_Chip-Seq_HEK293_Human1.35403557
67EP300_21415370_ChIP-Seq_HL-1_Mouse1.35083725
68* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.34749272
69FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34515544
70TCF4_18268006_ChIP-ChIP_LS174T_Human1.33987004
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32975012
72P300_19829295_ChIP-Seq_ESCs_Human1.32225724
73CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.32065299
74PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32051984
75AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.31185207
76VDR_24787735_ChIP-Seq_THP-1_Human1.30363931
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.30099775
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.29590390
79KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29483690
80* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.29407822
81MYB_21317192_ChIP-Seq_ERMYB_Mouse1.28808415
82CDX2_22108803_ChIP-Seq_LS180_Human1.28517209
83TRIM28_21343339_ChIP-Seq_HEK293_Human1.27740116
84TCF4_23295773_ChIP-Seq_U87_Human1.27477684
85TCF7_22412390_ChIP-Seq_EML_Mouse1.27283011
86GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.27259709
87RXR_22108803_ChIP-Seq_LS180_Human1.26029042
88AR_21572438_ChIP-Seq_LNCaP_Human1.25393298
89FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.24883107
90FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.24747428
91SOX2_20726797_ChIP-Seq_SW620_Human1.24508324
92CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23994184
93FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.23393088
94NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23385955
95MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.22917964
96E2F1_18555785_Chip-Seq_ESCs_Mouse1.22510043
97TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22171209
98SPI1_23127762_ChIP-Seq_K562_Human1.22129446
99BRD4_25478319_ChIP-Seq_HGPS_Human1.22045346
100* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21206363
101ESR2_21235772_ChIP-Seq_MCF-7_Human1.20695048
102SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.20547619
103SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.20547619
104IRF8_21731497_ChIP-ChIP_J774_Mouse1.20510855
105ER_23166858_ChIP-Seq_MCF-7_Human1.20429126
106SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.20156740
107FOXA1_25552417_ChIP-Seq_VCAP_Human1.19999657
108SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.19518387
109TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18980913
110EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17896209
111SMAD3_21741376_ChIP-Seq_EPCs_Human1.17621021
112SALL1_21062744_ChIP-ChIP_HESCs_Human1.15820419
113BCAT_22108803_ChIP-Seq_LS180_Human1.15727848
114SALL4_18804426_ChIP-ChIP_XEN_Mouse1.15487657
115PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13766037
116ESR1_20079471_ChIP-ChIP_T-47D_Human1.13285009
117ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12830439
118PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12643718
119FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.12394793
120GATA2_19941826_ChIP-Seq_K562_Human1.11745090
121CMYC_18555785_Chip-Seq_ESCs_Mouse1.10963412
122UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10308860
123SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09644099
124PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.09380437
125NFE2_27457419_Chip-Seq_LIVER_Mouse1.08502798
126RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.07947426
127AR_25329375_ChIP-Seq_VCAP_Human1.07609771
128KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04853695
129CJUN_26792858_Chip-Seq_BT549_Human1.04522272
130VDR_24763502_ChIP-Seq_THP-1_Human1.04498665
131P53_22387025_ChIP-Seq_ESCs_Mouse1.04470040
132VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04370758
133EWS_26573619_Chip-Seq_HEK293_Human1.04196416
134FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.03563046
135TBX20_22328084_ChIP-Seq_HEART_Mouse1.03377496
136TBX20_22080862_ChIP-Seq_HEART_Mouse1.03377496
137SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03305273
138OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03290303
139ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.01574039
140GATA3_27048872_Chip-Seq_THYMUS_Human0.99637005
141P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98342532
142RUNX1_27514584_Chip-Seq_MCF-7_Human0.98327084
143PU_27001747_Chip-Seq_BMDM_Mouse0.98155475
144BP1_19119308_ChIP-ChIP_Hs578T_Human0.97892413
145CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.97795319
146TP63_23658742_ChIP-Seq_EP156T_Human0.97692581
147TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.96464751
148FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.96332897
149CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95403972
150RUNX_20019798_ChIP-Seq_JUKART_Human0.93851445
151ARNT_22903824_ChIP-Seq_MCF-7_Human0.93786659
152* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93520097
153* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93520097
154DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93187474
155MYB_26560356_Chip-Seq_TH1_Human0.92320230
156NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91378944
157AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91174433

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog4.10520583
2MP0003300_gastrointestinal_ulcer3.45171528
3MP0008057_abnormal_DNA_replication3.06368064
4MP0000569_abnormal_digit_pigmentation2.98259581
5MP0000383_abnormal_hair_follicle2.61877115
6MP0005365_abnormal_bile_salt2.52897708
7MP0003252_abnormal_bile_duct2.39030427
8MP0008004_abnormal_stomach_pH2.36116934
9MP0005058_abnormal_lysosome_morphology2.36087992
10MP0003705_abnormal_hypodermis_morpholog2.32680728
11MP0010234_abnormal_vibrissa_follicle2.22290610
12MP0004264_abnormal_extraembryonic_tissu2.21118929
13MP0002693_abnormal_pancreas_physiology2.20800036
14MP0009780_abnormal_chondrocyte_physiolo2.15959285
15MP0003283_abnormal_digestive_organ2.11555323
16MP0003183_abnormal_peptide_metabolism1.99471262
17MP0002166_altered_tumor_susceptibility1.97914868
18MP0003191_abnormal_cellular_cholesterol1.96231776
19MP0002139_abnormal_hepatobiliary_system1.95667312
20MP0004185_abnormal_adipocyte_glucose1.82254041
21MP0010352_gastrointestinal_tract_polyps1.80524550
22MP0004043_abnormal_pH_regulation1.79555569
23MP0003195_calcinosis1.76853931
24MP0001944_abnormal_pancreas_morphology1.76436600
25MP0005076_abnormal_cell_differentiation1.74468581
26MP0003828_pulmonary_edema1.70335391
27MP0003724_increased_susceptibility_to1.69803099
28MP0003045_fibrosis1.67391424
29MP0003566_abnormal_cell_adhesion1.65222523
30MP0003172_abnormal_lysosome_physiology1.60733526
31MP0003950_abnormal_plasma_membrane1.59777690
32MP0005360_urolithiasis1.58598791
33MP0005085_abnormal_gallbladder_physiolo1.51379170
34MP0002254_reproductive_system_inflammat1.51143004
35MP0001666_abnormal_nutrient_absorption1.47629895
36MP0002060_abnormal_skin_morphology1.47251595
37MP0005409_darkened_coat_color1.46008881
38MP0010155_abnormal_intestine_physiology1.45605063
39MP0005220_abnormal_exocrine_pancreas1.41696418
40MP0010307_abnormal_tumor_latency1.40884191
41MP0005257_abnormal_intraocular_pressure1.39901326
42MP0003890_abnormal_embryonic-extraembry1.39416631
43MP0002909_abnormal_adrenal_gland1.38405927
44MP0002928_abnormal_bile_duct1.37365295
45MP0009840_abnormal_foam_cell1.34136502
46MP0005310_abnormal_salivary_gland1.34016770
47MP0002078_abnormal_glucose_homeostasis1.33741912
48MP0004084_abnormal_cardiac_muscle1.33361556
49MP0002006_tumorigenesis1.32233973
50MP0000609_abnormal_liver_physiology1.31777286
51MP0008438_abnormal_cutaneous_collagen1.31191978
52MP0008961_abnormal_basal_metabolism1.31179859
53MP0000013_abnormal_adipose_tissue1.28618531
54MP0004947_skin_inflammation1.26940067
55MP0002896_abnormal_bone_mineralization1.26869673
56MP0000003_abnormal_adipose_tissue1.24323624
57MP0004036_abnormal_muscle_relaxation1.23732993
58MP0003868_abnormal_feces_composition1.22231137
59MP0005275_abnormal_skin_tensile1.20608016
60MP0008875_abnormal_xenobiotic_pharmacok1.20410206
61MP0001873_stomach_inflammation1.18158054
62MP0010329_abnormal_lipoprotein_level1.16131256
63MP0005647_abnormal_sex_gland1.16022847
64MP0005670_abnormal_white_adipose1.14479416
65MP0005666_abnormal_adipose_tissue1.14187500
66MP0006054_spinal_hemorrhage1.13918102
67MP0009115_abnormal_fat_cell1.12603470
68MP0003303_peritoneal_inflammation1.12308673
69MP0004130_abnormal_muscle_cell1.12116842
70MP0003941_abnormal_skin_development1.10150808
71MP0001661_extended_life_span1.08402650
72MP0001879_abnormal_lymphatic_vessel1.07860012
73MP0005375_adipose_tissue_phenotype1.07174244
74MP0009643_abnormal_urine_homeostasis1.06389904
75MP0005248_abnormal_Harderian_gland1.05427336
76MP0002138_abnormal_hepatobiliary_system1.02434447
77MP0000371_diluted_coat_color1.02200282
78MP0001851_eye_inflammation1.01357488
79MP0002009_preneoplasia1.01010175
80MP0000490_abnormal_crypts_of1.00949672
81MP0001849_ear_inflammation0.99578544
82MP0004134_abnormal_chest_morphology0.98122817
83MP0005174_abnormal_tail_pigmentation0.96626893
84MP0004484_altered_response_of0.95742468
85MP0008775_abnormal_heart_ventricle0.95634187
86MP0002168_other_aberrant_phenotype0.95271814
87MP0000604_amyloidosis0.94036903
88MP0000733_abnormal_muscle_development0.91350495
89MP0002118_abnormal_lipid_homeostasis0.91304195
90MP0002234_abnormal_pharynx_morphology0.91049020
91MP0000427_abnormal_hair_cycle0.90914010
92MP0003656_abnormal_erythrocyte_physiolo0.90740295
93MP0000377_abnormal_hair_follicle0.90529643
94MP0003763_abnormal_thymus_physiology0.86801607
95MP0000015_abnormal_ear_pigmentation0.86697994
96MP0001191_abnormal_skin_condition0.86517149
97MP0003690_abnormal_glial_cell0.84427893
98MP0003866_abnormal_defecation0.84277389
99MP0009703_decreased_birth_body0.84081073
100MP0004272_abnormal_basement_membrane0.84047111
101MP0001835_abnormal_antigen_presentation0.83737555
102MP0004215_abnormal_myocardial_fiber0.82646596
103MP0010386_abnormal_urinary_bladder0.82601875
104MP0005379_endocrine/exocrine_gland_phen0.82251824
105MP0009672_abnormal_birth_weight0.81712558
106MP0001216_abnormal_epidermal_layer0.81012129
107MP0003436_decreased_susceptibility_to0.80929695
108MP0010678_abnormal_skin_adnexa0.80886120
109MP0000462_abnormal_digestive_system0.79867804
110MP0003453_abnormal_keratinocyte_physiol0.78795747
111MP0000477_abnormal_intestine_morphology0.78682250
112MP0001756_abnormal_urination0.78326876
113MP0003632_abnormal_nervous_system0.78190634
114MP0005334_abnormal_fat_pad0.77662475
115MP0001958_emphysema0.76478618
116MP0005167_abnormal_blood-brain_barrier0.76442778
117MP0004883_abnormal_blood_vessel0.76439520
118MP0002971_abnormal_brown_adipose0.76060289
119MP0000647_abnormal_sebaceous_gland0.75796976
120MP0009278_abnormal_bone_marrow0.74866370
121MP0001845_abnormal_inflammatory_respons0.72277716
122MP0001765_abnormal_ion_homeostasis0.72256376
123MP0005023_abnormal_wound_healing0.72154848
124MP0005451_abnormal_body_composition0.71868880
125MP0000678_abnormal_parathyroid_gland0.70130264
126MP0000249_abnormal_blood_vessel0.69763836
127MP0003795_abnormal_bone_structure0.69383270
128MP0006138_congestive_heart_failure0.68688753
129MP0002998_abnormal_bone_remodeling0.67689901
130MP0000465_gastrointestinal_hemorrhage0.67540696
131MP0000598_abnormal_liver_morphology0.66917579
132MP0009697_abnormal_copulation0.66539326
133MP0005164_abnormal_response_to0.66472336
134MP0004381_abnormal_hair_follicle0.66435872
135MP0006082_CNS_inflammation0.66283076
136MP0005408_hypopigmentation0.63973237
137MP0005448_abnormal_energy_balance0.63891441
138MP0005464_abnormal_platelet_physiology0.63438639
139MP0005083_abnormal_biliary_tract0.63056035
140MP0003011_delayed_dark_adaptation0.62699749
141MP0002796_impaired_skin_barrier0.62402536
142MP0004808_abnormal_hematopoietic_stem0.62068399
143MP0003091_abnormal_cell_migration0.62041448
144MP0002128_abnormal_blood_circulation0.61810163
145MP0001533_abnormal_skeleton_physiology0.61717313

Predicted human phenotypes

RankGene SetZ-score
1Pustule (HP:0200039)5.21176648
2Hypoglycemic coma (HP:0001325)4.42538583
3Hyperinsulinemic hypoglycemia (HP:0000825)4.38874116
4Hypoglycemic seizures (HP:0002173)4.16120405
5Papillary thyroid carcinoma (HP:0002895)4.12157811
6Insulin-resistant diabetes mellitus (HP:0000831)3.95957561
7Hyperglycemia (HP:0003074)3.94489357
8Alopecia of scalp (HP:0002293)3.61243714
9Urinary glycosaminoglycan excretion (HP:0003541)3.43897292
10Mucopolysacchariduria (HP:0008155)3.43897292
11Symptomatic seizures (HP:0011145)3.32660789
12Abnormality of glycosaminoglycan metabolism (HP:0004371)3.24320495
13Abnormality of mucopolysaccharide metabolism (HP:0011020)3.24320495
14Abnormality of polysaccharide metabolism (HP:0011012)3.24320495
15Dysostosis multiplex (HP:0000943)3.06833121
16Flat acetabular roof (HP:0003180)3.06211665
17Abnormality of the vasculature of the conjunctiva (HP:0008054)3.04299597
18Curly hair (HP:0002212)2.92882064
19Abnormality of glycolipid metabolism (HP:0010969)2.92636556
20Abnormality of liposaccharide metabolism (HP:0010968)2.92636556
21Abnormality of glycosphingolipid metabolism (HP:0004343)2.92636556
22Myocardial infarction (HP:0001658)2.81911587
23Abnormal pancreas size (HP:0012094)2.80455952
24Pancreatic islet-cell hyperplasia (HP:0004510)2.79947901
25Thyroid carcinoma (HP:0002890)2.78726300
26Abnormality of the axillary hair (HP:0100134)2.68958138
27Abnormality of secondary sexual hair (HP:0009888)2.68958138
28Abnormality of the distal phalanges of the toes (HP:0010182)2.68518996
29Hematochezia (HP:0002573)2.60268210
30Abnormality of the intrinsic pathway (HP:0010989)2.57821827
31Cerebral aneurysm (HP:0004944)2.55929374
32Intrahepatic cholestasis (HP:0001406)2.55903549
33Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.55745977
34Abnormality of the pancreatic islet cells (HP:0006476)2.55475028
35Abnormality of endocrine pancreas physiology (HP:0012093)2.55475028
36Spontaneous hematomas (HP:0007420)2.47726259
37Gingival bleeding (HP:0000225)2.41369954
38Ketoacidosis (HP:0001993)2.41293122
39Fair hair (HP:0002286)2.41087060
40Abnormality of the common coagulation pathway (HP:0010990)2.39096792
41Increased mean platelet volume (HP:0011877)2.37255656
42Overgrowth (HP:0001548)2.37113274
43Chronic diarrhea (HP:0002028)2.33706686
44Asymmetric septal hypertrophy (HP:0001670)2.33575167
45Macroorchidism (HP:0000053)2.32630435
46Increased cerebral lipofuscin (HP:0011813)2.31168833
47Severe short stature (HP:0003510)2.30331776
48Conjunctival telangiectasia (HP:0000524)2.28490613
49Chronic hepatic failure (HP:0100626)2.28084165
50Portal hypertension (HP:0001409)2.26526156
51Periodontitis (HP:0000704)2.26239738
52Tubulointerstitial nephritis (HP:0001970)2.26175212
53Abnormality of the fingertips (HP:0001211)2.26174068
54Hypoalphalipoproteinemia (HP:0003233)2.25278264
55Conjugated hyperbilirubinemia (HP:0002908)2.24846345
56Acanthocytosis (HP:0001927)2.23498243
57Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.19501435
58T lymphocytopenia (HP:0005403)2.19409853
59Neonatal hypoglycemia (HP:0001998)2.19020079
60Insulin resistance (HP:0000855)2.18884732
61Abnormal foot bone ossification (HP:0010675)2.18551136
62Skin nodule (HP:0200036)2.17499323
63Abdominal distention (HP:0003270)2.16583608
64Submucous cleft hard palate (HP:0000176)2.13093347
65Widely spaced teeth (HP:0000687)2.12765188
66Hyperventilation (HP:0002883)2.12525869
67Increased CSF protein (HP:0002922)2.12286552
68Xanthomatosis (HP:0000991)2.09962407
69Thyroiditis (HP:0100646)2.09107017
70Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.08884075
71Osteolytic defects of the hand bones (HP:0009699)2.08401704
72Osteolytic defects of the phalanges of the hand (HP:0009771)2.08401704
73Abnormal glucose tolerance (HP:0001952)2.05304060
74Decreased circulating renin level (HP:0003351)2.05121166
75Tubulointerstitial abnormality (HP:0001969)2.04236356
76Transitional cell carcinoma of the bladder (HP:0006740)2.03467394
77Absent frontal sinuses (HP:0002688)2.03092548
78Abnormality of the renal cortex (HP:0011035)2.02699100
79Vacuolated lymphocytes (HP:0001922)2.01975940
80Large for gestational age (HP:0001520)2.00958505
81Abnormal platelet volume (HP:0011876)2.00898443
82Neoplasm of the adrenal cortex (HP:0100641)2.00767394
83Colitis (HP:0002583)2.00414007
84Cervical subluxation (HP:0003308)1.99317182
85Cheilitis (HP:0100825)1.98971551
86Broad metatarsal (HP:0001783)1.97930316
87Subacute progressive viral hepatitis (HP:0006572)1.97684030
88Coarse hair (HP:0002208)1.97227294
89Abnormality of the periventricular white matter (HP:0002518)1.96761972
90Hyperkalemia (HP:0002153)1.95570375
91Abnormality of the nasal septum (HP:0000419)1.95214288
92Bladder carcinoma (HP:0002862)1.95126159
93Bladder neoplasm (HP:0009725)1.95126159
94Abnormality of the hepatic vasculature (HP:0006707)1.94959000
95Thickened calvaria (HP:0002684)1.94464955
96Aneurysm (HP:0002617)1.93837915
97Narrow palate (HP:0000189)1.93083148
98Abnormality of T cell number (HP:0011839)1.92007231
99Hepatoblastoma (HP:0002884)1.91323960
100Autoimmune thrombocytopenia (HP:0001973)1.90729180
101Right ventricular cardiomyopathy (HP:0011663)1.89491758
102Hypoplastic ischia (HP:0003175)1.89329814
103Acute myeloid leukemia (HP:0004808)1.88009345
104Menstrual irregularities (HP:0000858)1.87649822
105Autoimmune hemolytic anemia (HP:0001890)1.85902628
106Large earlobe (HP:0009748)1.85895264
107Protuberant abdomen (HP:0001538)1.84686879
108Hypoplastic labia majora (HP:0000059)1.84218323
109Truncal obesity (HP:0001956)1.83491838
110Ectropion (HP:0000656)1.83118632
111Abnormality of monocarboxylic acid metabolism (HP:0010996)1.82757245
112Heterotopia (HP:0002282)1.81027611
113Facial diplegia (HP:0001349)1.80268886
114Neoplasm of the tracheobronchial system (HP:0100552)1.80248949
115Prolonged bleeding time (HP:0003010)1.80082747
116Abnormality of the epiphyses of the hand (HP:0005924)1.79592240
117Disinhibition (HP:0000734)1.79438855
118Abnormality of alkaline phosphatase activity (HP:0004379)1.79289235
119Renal cortical cysts (HP:0000803)1.79183513
120Abnormal enzyme/coenzyme activity (HP:0012379)1.78954561
121Persistence of primary teeth (HP:0006335)1.78905245
122Inflammation of the large intestine (HP:0002037)1.78546303
123Ketosis (HP:0001946)1.78476686
124Abnormality of the ischium (HP:0003174)1.77127595
125Turricephaly (HP:0000262)1.77127082
126Late onset (HP:0003584)1.76736855
127Aortic aneurysm (HP:0004942)1.75742859
128Short 1st metacarpal (HP:0010034)1.74809490
129Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.74809490
130Esophageal varix (HP:0002040)1.74401505
131Generalized hypopigmentation of hair (HP:0011358)1.74119749
132Recurrent abscess formation (HP:0002722)1.73766601
133Eczematoid dermatitis (HP:0000976)1.72863696
134Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.72410769
135Tubulointerstitial fibrosis (HP:0005576)1.70874886
136Gingivitis (HP:0000230)1.70730114
137Abnormal biliary tract morphology (HP:0012440)1.70503992
138Prostate neoplasm (HP:0100787)1.69769338
139Biliary tract neoplasm (HP:0100574)1.69544515
140Spondylolisthesis (HP:0003302)1.69522004
141Bilateral sensorineural hearing impairment (HP:0008619)1.69178559
142Global brain atrophy (HP:0002283)1.68883030
143Aortic dissection (HP:0002647)1.68308925
144Abnormality of purine metabolism (HP:0004352)1.68211579
145Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.68077603
146Thin bony cortex (HP:0002753)1.67023013
147Anhidrosis (HP:0000970)1.66607490
148Retinal atrophy (HP:0001105)1.66455280
149Hypophosphatemia (HP:0002148)1.66167533
150Epidermoid cyst (HP:0200040)1.66141480
151Complement deficiency (HP:0004431)1.65877763
152Sandal gap (HP:0001852)1.65714942
153Thoracolumbar scoliosis (HP:0002944)1.65401340
154Enlarged kidneys (HP:0000105)1.63577892
155Abnormality of the gastric mucosa (HP:0004295)1.63400298
156Urethral obstruction (HP:0000796)1.62752732
157Germ cell neoplasia (HP:0100728)1.61798906
158Abnormality of the labia majora (HP:0012881)1.61744040
159Hypokalemia (HP:0002900)1.61171677
160Recurrent gram-negative bacterial infections (HP:0005420)1.60334757
161Gastrointestinal inflammation (HP:0004386)1.60048219
162Hip dysplasia (HP:0001385)1.59612643
163Milia (HP:0001056)1.59010751
164Gonadotropin excess (HP:0000837)1.58991901
165Increased neuronal autofluorescent lipopigment (HP:0002074)1.58009620
166Menorrhagia (HP:0000132)1.57907505
167Distal lower limb amyotrophy (HP:0008944)1.57595396
168Long foot (HP:0001833)1.57412919
169Increased connective tissue (HP:0009025)1.57329708
170Mitral valve prolapse (HP:0001634)1.57011172

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK34.25814940
2INSRR3.77144004
3AKT33.65379167
4ACVR1B3.63511005
5FRK3.56804005
6CAMK1D3.29340227
7CDK122.97616186
8PIK3CA2.64932100
9LATS12.49940153
10CAMK1G2.48678008
11MAP3K22.06841623
12NLK2.05992942
13TRIB31.97624029
14RIPK11.95429081
15PASK1.94357998
16PTK61.84599274
17TTN1.83075074
18PDGFRA1.74897159
19SCYL21.71578903
20ERN11.69811512
21STK38L1.69423296
22STK391.68543281
23HIPK21.66273951
24SIK11.58937328
25FGFR31.48865129
26PRKG21.47219773
27EIF2AK31.42443726
28JAK11.41805835
29IRAK31.40579979
30FGFR21.38457511
31PKN21.35725409
32ERBB31.34664693
33MAPK151.29822603
34OBSCN1.28164471
35MAP3K31.26635405
36TGFBR21.23771922
37MST41.22945651
38FLT31.22406575
39STK31.22290896
40PDGFRB1.19487932
41FGFR41.19413580
42TYK21.14073024
43EPHA31.13238781
44MTOR1.12783560
45ITK1.08846994
46BRSK21.08652485
47CDK31.08269508
48JAK21.07565520
49NEK91.07512431
50CDK61.06714312
51SGK2231.06091552
52SGK4941.06091552
53NUAK11.05290129
54PRKD31.04910318
55IRAK11.02492765
56STK241.00671188
57BLK1.00330322
58YES10.99191272
59BRD40.94888002
60BMPR20.93480916
61PRKCH0.92681556
62JAK30.91707672
63CDC42BPA0.91196252
64SGK30.90950956
65PRKAA20.88228404
66MST1R0.87337177
67PTK20.86190365
68TNIK0.83718286
69EPHB10.82993755
70CSK0.77258119
71CAMKK20.77111369
72MAP3K100.74856219
73DMPK0.73713080
74CHUK0.73023382
75BTK0.72007841
76PRKAA10.70906535
77STK100.70554429
78FGFR10.70286231
79MET0.70079540
80WNK10.69145498
81DDR20.68993266
82FGR0.68783925
83OXSR10.67744406
84ALK0.64515614
85PIK3CG0.62746002
86MAP3K10.62701736
87MARK20.62689206
88MARK30.62045733
89TRPM70.61639507
90TIE10.61534715
91MAP4K20.60882420
92BCR0.60716016
93CDK90.58571295
94DYRK1B0.58201942
95NEK60.57796053
96BMPR1B0.57518603
97GSK3A0.57463252
98GRK70.55724809
99RPS6KA40.55141116
100ZAP700.54618272
101SGK20.53636570
102CSF1R0.52104710
103PRKD10.52102161
104RET0.51935937
105PDK10.50635905
106KIT0.48098445
107TGFBR10.47551952
108MAP3K140.47170627
109EEF2K0.45782445
110RPS6KB10.45456063
111MAPK110.45173670
112TBK10.45048376
113MAP3K70.44971330
114PDK20.43972925
115FER0.43836715
116IGF1R0.43299224
117MAPK70.42878588
118SGK10.42848123
119CAMK40.42795890
120EPHA20.42569274
121MAP2K30.42467262
122TEC0.42079225
123IKBKB0.41887772
124HCK0.39420804
125PRKD20.38779223
126CAMK2D0.38603474
127ERBB20.36905319
128PAK20.36626332
129EGFR0.36259572
130WNK30.35213389
131IKBKE0.34102012
132PAK30.34076230
133RIPK40.33845949
134PRKCE0.32404141
135LRRK20.31146457
136PRKACG0.30603390
137ABL10.30561130
138MAP4K10.30410898
139IRAK40.29442694
140RPS6KA20.29232018
141LCK0.27911770
142LMTK20.27815940
143MELK0.27540833
144TTK0.27180937

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.00818324
2Sulfur metabolism_Homo sapiens_hsa009202.98190961
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.51039277
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.18895497
5Type II diabetes mellitus_Homo sapiens_hsa049302.07082614
6Nitrogen metabolism_Homo sapiens_hsa009101.93043097
7Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.86746170
8ABC transporters_Homo sapiens_hsa020101.86051707
9Carbohydrate digestion and absorption_Homo sapiens_hsa049731.82819597
10Caffeine metabolism_Homo sapiens_hsa002321.78783492
11Fatty acid biosynthesis_Homo sapiens_hsa000611.75271700
12Insulin resistance_Homo sapiens_hsa049311.73025532
13Lysine degradation_Homo sapiens_hsa003101.66383137
14Lysosome_Homo sapiens_hsa041421.49285644
15Selenocompound metabolism_Homo sapiens_hsa004501.49061994
16Tryptophan metabolism_Homo sapiens_hsa003801.45624758
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.43772078
18Sphingolipid metabolism_Homo sapiens_hsa006001.38734622
19Insulin secretion_Homo sapiens_hsa049111.27219965
20Staphylococcus aureus infection_Homo sapiens_hsa051501.24155049
21Circadian rhythm_Homo sapiens_hsa047101.22041666
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.18677357
23Butanoate metabolism_Homo sapiens_hsa006501.15663274
24Glucagon signaling pathway_Homo sapiens_hsa049221.14763892
25Adipocytokine signaling pathway_Homo sapiens_hsa049201.13598694
26Starch and sucrose metabolism_Homo sapiens_hsa005001.12025412
27Fat digestion and absorption_Homo sapiens_hsa049751.10737495
28Systemic lupus erythematosus_Homo sapiens_hsa053221.10113945
29Complement and coagulation cascades_Homo sapiens_hsa046101.07089127
30mTOR signaling pathway_Homo sapiens_hsa041501.05820243
31Adherens junction_Homo sapiens_hsa045201.04252797
32Osteoclast differentiation_Homo sapiens_hsa043801.03605020
33Dorso-ventral axis formation_Homo sapiens_hsa043200.97902922
34Fatty acid degradation_Homo sapiens_hsa000710.96827933
35Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.96600296
36PPAR signaling pathway_Homo sapiens_hsa033200.95095867
37Non-small cell lung cancer_Homo sapiens_hsa052230.94703522
38Bile secretion_Homo sapiens_hsa049760.94624377
39Steroid biosynthesis_Homo sapiens_hsa001000.94294591
40Other glycan degradation_Homo sapiens_hsa005110.91797576
41Pancreatic secretion_Homo sapiens_hsa049720.91421417
42Choline metabolism in cancer_Homo sapiens_hsa052310.90218785
43Longevity regulating pathway - mammal_Homo sapiens_hsa042110.89528057
44Prostate cancer_Homo sapiens_hsa052150.89486041
45Chronic myeloid leukemia_Homo sapiens_hsa052200.87631982
46Prolactin signaling pathway_Homo sapiens_hsa049170.87439502
47Histidine metabolism_Homo sapiens_hsa003400.86972820
48Antigen processing and presentation_Homo sapiens_hsa046120.86427702
49Focal adhesion_Homo sapiens_hsa045100.85973878
50Amoebiasis_Homo sapiens_hsa051460.85886671
51FoxO signaling pathway_Homo sapiens_hsa040680.84197205
52Mineral absorption_Homo sapiens_hsa049780.84039054
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82508474
54Toxoplasmosis_Homo sapiens_hsa051450.82394739
55AMPK signaling pathway_Homo sapiens_hsa041520.80521045
56Renin secretion_Homo sapiens_hsa049240.79524624
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78949615
58Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78288156
59Glycerolipid metabolism_Homo sapiens_hsa005610.76444386
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76137889
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75426462
62Insulin signaling pathway_Homo sapiens_hsa049100.74698370
63Thyroid hormone synthesis_Homo sapiens_hsa049180.74069983
64Protein export_Homo sapiens_hsa030600.72921130
65Renin-angiotensin system_Homo sapiens_hsa046140.72685938
66T cell receptor signaling pathway_Homo sapiens_hsa046600.72147747
67Proteoglycans in cancer_Homo sapiens_hsa052050.71411887
68Colorectal cancer_Homo sapiens_hsa052100.71311336
69Ovarian steroidogenesis_Homo sapiens_hsa049130.71178173
70Inositol phosphate metabolism_Homo sapiens_hsa005620.70878560
71Ether lipid metabolism_Homo sapiens_hsa005650.70742075
72Small cell lung cancer_Homo sapiens_hsa052220.70734507
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.70624368
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.70280373
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70064871
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70034430
77TGF-beta signaling pathway_Homo sapiens_hsa043500.69398600
78Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.68526284
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.68348586
80ECM-receptor interaction_Homo sapiens_hsa045120.68060208
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.67708365
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.65300789
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65254305
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64987161
85Protein digestion and absorption_Homo sapiens_hsa049740.64927705
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63304528
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62862083
88Glioma_Homo sapiens_hsa052140.62683153
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.62317255
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.61930522
91Leishmaniasis_Homo sapiens_hsa051400.61007195
92Type I diabetes mellitus_Homo sapiens_hsa049400.60924453
93NF-kappa B signaling pathway_Homo sapiens_hsa040640.60201310
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59470503
95Hematopoietic cell lineage_Homo sapiens_hsa046400.59023261
96Endometrial cancer_Homo sapiens_hsa052130.58968621
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58406957
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58174087
99Galactose metabolism_Homo sapiens_hsa000520.57948039
100Phenylalanine metabolism_Homo sapiens_hsa003600.56918222
101ErbB signaling pathway_Homo sapiens_hsa040120.56551597
102Thyroid cancer_Homo sapiens_hsa052160.56525324
103Hepatitis B_Homo sapiens_hsa051610.56296757
104Propanoate metabolism_Homo sapiens_hsa006400.56104625
105Malaria_Homo sapiens_hsa051440.55432674
106Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54265193
107HIF-1 signaling pathway_Homo sapiens_hsa040660.54122057
108African trypanosomiasis_Homo sapiens_hsa051430.53821954
109Legionellosis_Homo sapiens_hsa051340.52791788
110Tuberculosis_Homo sapiens_hsa051520.52583500
111Fatty acid metabolism_Homo sapiens_hsa012120.52494796
112Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52338086
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52223685
114Hepatitis C_Homo sapiens_hsa051600.52057088
115Platelet activation_Homo sapiens_hsa046110.51935903
116Estrogen signaling pathway_Homo sapiens_hsa049150.51891325
117Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50651254
118MicroRNAs in cancer_Homo sapiens_hsa052060.50475159
119Pancreatic cancer_Homo sapiens_hsa052120.50393952
120AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49349209
121Influenza A_Homo sapiens_hsa051640.48958208
122Arginine biosynthesis_Homo sapiens_hsa002200.48745267
123Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48652963
124NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47164850
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46799075
126B cell receptor signaling pathway_Homo sapiens_hsa046620.46098258
127Apoptosis_Homo sapiens_hsa042100.45883470
128Phagosome_Homo sapiens_hsa041450.44054981
129TNF signaling pathway_Homo sapiens_hsa046680.43095835
130Acute myeloid leukemia_Homo sapiens_hsa052210.42188676
131Toll-like receptor signaling pathway_Homo sapiens_hsa046200.41984641
132Viral carcinogenesis_Homo sapiens_hsa052030.40099373
133Renal cell carcinoma_Homo sapiens_hsa052110.39941998
134Measles_Homo sapiens_hsa051620.39064195

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