DENR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein whose expression was found to increase in cultured cells at high density but not during growth arrest. This gene was also shown to have increased expression in cells overexpressing HER-2/neu proto-oncogene. The protein contains an SUI1 domain. In budding yeast, SUI1 is a translation initiation factor that along with eIF-2 and the initiator tRNA-Met, directs the ribosome to the proper translation start site. Proteins similar to SUI have been found in mammals, insects, and plants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)5.30640592
2ribosomal small subunit assembly (GO:0000028)5.04762556
3proteasome assembly (GO:0043248)5.01115749
4ribosomal small subunit biogenesis (GO:0042274)4.97842351
5viral transcription (GO:0019083)4.88827909
6translational termination (GO:0006415)4.83503566
7ribosomal large subunit biogenesis (GO:0042273)4.75940612
8DNA deamination (GO:0045006)4.70680444
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.45284325
10cotranslational protein targeting to membrane (GO:0006613)4.40434666
11protein targeting to ER (GO:0045047)4.36099610
12translational elongation (GO:0006414)4.23937118
13negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.23049697
14* translational initiation (GO:0006413)4.19522588
15ribonucleoprotein complex biogenesis (GO:0022613)4.19210967
16protein localization to endoplasmic reticulum (GO:0070972)4.14230466
17establishment of protein localization to endoplasmic reticulum (GO:0072599)4.13165507
18* formation of translation preinitiation complex (GO:0001731)4.09771836
19positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.98917877
20termination of RNA polymerase III transcription (GO:0006386)3.96104005
21transcription elongation from RNA polymerase III promoter (GO:0006385)3.96104005
22regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.88893657
23nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.87493042
24negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.85967086
25negative regulation of ligase activity (GO:0051352)3.85967086
26translation (GO:0006412)3.85589777
27cellular protein complex disassembly (GO:0043624)3.84776412
28spliceosomal snRNP assembly (GO:0000387)3.84650503
29viral life cycle (GO:0019058)3.84081569
30anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.82567742
31establishment of integrated proviral latency (GO:0075713)3.77993075
32DNA strand elongation involved in DNA replication (GO:0006271)3.75012388
33chromatin remodeling at centromere (GO:0031055)3.74585925
34protein localization to kinetochore (GO:0034501)3.74283837
35rRNA processing (GO:0006364)3.73911259
36CENP-A containing nucleosome assembly (GO:0034080)3.73586231
37DNA unwinding involved in DNA replication (GO:0006268)3.73271311
38mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.72703279
39regulation of cellular amino acid metabolic process (GO:0006521)3.72478449
40pseudouridine synthesis (GO:0001522)3.71769789
41telomere maintenance via semi-conservative replication (GO:0032201)3.71342167
42ribosome biogenesis (GO:0042254)3.70131104
43antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.70063280
44DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.69123915
45ribosome assembly (GO:0042255)3.68766153
46establishment of protein localization to mitochondrial membrane (GO:0090151)3.68193777
47DNA replication checkpoint (GO:0000076)3.65727749
48signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.63903023
49intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.63903023
50IMP biosynthetic process (GO:0006188)3.62925199
51signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.61886167
52signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.61886167
53signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.61886167
54rRNA metabolic process (GO:0016072)3.61361858
55signal transduction involved in DNA damage checkpoint (GO:0072422)3.56254082
56signal transduction involved in DNA integrity checkpoint (GO:0072401)3.56254082
57DNA strand elongation (GO:0022616)3.55997181
58positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.54277955
59antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.51223364
60signal transduction involved in cell cycle checkpoint (GO:0072395)3.50749801
61DNA damage response, detection of DNA damage (GO:0042769)3.49410624
62cellular component biogenesis (GO:0044085)3.46381078
63DNA replication initiation (GO:0006270)3.45851778
64mitotic sister chromatid segregation (GO:0000070)3.44971636
65ATP synthesis coupled proton transport (GO:0015986)3.42108795
66energy coupled proton transport, down electrochemical gradient (GO:0015985)3.42108795
67nucleobase biosynthetic process (GO:0046112)3.41522441
68purine nucleobase biosynthetic process (GO:0009113)3.41437045
69spliceosomal complex assembly (GO:0000245)3.41348828
70positive regulation of ligase activity (GO:0051351)3.41223058
71telomere maintenance via recombination (GO:0000722)3.40354441
727-methylguanosine mRNA capping (GO:0006370)3.38745478
73regulation of helicase activity (GO:0051095)3.37144221
747-methylguanosine RNA capping (GO:0009452)3.36823142
75RNA capping (GO:0036260)3.36823142
76mitotic metaphase plate congression (GO:0007080)3.35853552
77protein neddylation (GO:0045116)3.35547168
78rRNA modification (GO:0000154)3.35153098
79IMP metabolic process (GO:0046040)3.34461001
80protein complex disassembly (GO:0043241)3.32535103
81kinetochore organization (GO:0051383)3.29353579
82DNA ligation (GO:0006266)3.28922219
83DNA replication-dependent nucleosome assembly (GO:0006335)3.27252631
84DNA replication-dependent nucleosome organization (GO:0034723)3.27252631
85kinetochore assembly (GO:0051382)3.27119236
86cullin deneddylation (GO:0010388)3.26643159
87sister chromatid segregation (GO:0000819)3.24145924
88nuclear pore organization (GO:0006999)3.23654702
89nuclear pore complex assembly (GO:0051292)3.22792518
90maturation of 5.8S rRNA (GO:0000460)3.20671256
91regulation of mitochondrial translation (GO:0070129)3.19902989
92DNA double-strand break processing (GO:0000729)3.18908606
93metaphase plate congression (GO:0051310)3.18647469
94* macromolecular complex disassembly (GO:0032984)3.18533712
95chaperone-mediated protein transport (GO:0072321)3.18472798
96nucleobase-containing small molecule interconversion (GO:0015949)3.18149492
97protein localization to chromosome, centromeric region (GO:0071459)3.18034225
98establishment of viral latency (GO:0019043)3.17901695
99deoxyribonucleotide biosynthetic process (GO:0009263)3.17771289
100DNA replication-independent nucleosome organization (GO:0034724)3.16734893
101DNA replication-independent nucleosome assembly (GO:0006336)3.16734893
102transcription-coupled nucleotide-excision repair (GO:0006283)3.14903616
103exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.12114653
104regulation of ubiquitin-protein transferase activity (GO:0051438)3.10585302
105mitotic recombination (GO:0006312)3.10552672
106deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.10139531
107cell cycle G1/S phase transition (GO:0044843)3.09589211
108G1/S transition of mitotic cell cycle (GO:0000082)3.09589211
109nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.09218363
110negative regulation of mitotic sister chromatid separation (GO:2000816)3.08852134
111negative regulation of sister chromatid segregation (GO:0033046)3.08852134
112negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.08852134
113negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.08852134
114negative regulation of mitotic sister chromatid segregation (GO:0033048)3.08852134
115regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.08705049
116regulation of mitotic spindle checkpoint (GO:1903504)3.08705049
117spindle checkpoint (GO:0031577)3.08242429
118negative regulation of chromosome segregation (GO:0051985)3.07603518
119viral mRNA export from host cell nucleus (GO:0046784)3.07354987
120histone mRNA metabolic process (GO:0008334)3.05353412
121nuclear-transcribed mRNA catabolic process (GO:0000956)3.05321513
122L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.03722856
123mitotic spindle checkpoint (GO:0071174)3.03680679
124protein deneddylation (GO:0000338)3.03176097
125double-strand break repair via nonhomologous end joining (GO:0006303)3.02968740
126non-recombinational repair (GO:0000726)3.02968740
127regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.02944788
128histone exchange (GO:0043486)3.02676389
129telomere maintenance via telomere lengthening (GO:0010833)3.02593994
130regulation of ligase activity (GO:0051340)3.01561929
131ATP-dependent chromatin remodeling (GO:0043044)3.01547118
132mitotic sister chromatid cohesion (GO:0007064)3.00899476
133deoxyribose phosphate biosynthetic process (GO:0046385)2.98969738
134termination of RNA polymerase II transcription (GO:0006369)2.97747073
135regulation of centriole replication (GO:0046599)2.97563362
136nucleotide-excision repair, DNA gap filling (GO:0006297)2.86604690
137mitotic spindle assembly checkpoint (GO:0007094)2.86043345
138spindle assembly checkpoint (GO:0071173)2.85076371
139L-serine metabolic process (GO:0006563)2.83803843
140regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.82640757
141regulation of mitotic metaphase/anaphase transition (GO:0030071)2.82640757

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.60484707
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.81414492
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.19708253
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.17809058
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.93896783
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.83491606
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.66096191
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.52766908
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.25748227
10MYC_19079543_ChIP-ChIP_MESCs_Mouse3.16860338
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.14140896
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.09051192
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.05974349
14* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.99875837
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.99349737
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.90648357
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.85666689
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.76576010
19VDR_23849224_ChIP-Seq_CD4+_Human2.72798758
20XRN2_22483619_ChIP-Seq_HELA_Human2.58406959
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.57908423
22* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.56207209
23* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.50733709
24DCP1A_22483619_ChIP-Seq_HELA_Human2.48114678
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.43045060
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.35836314
27ELK1_19687146_ChIP-ChIP_HELA_Human2.35457567
28ELF1_17652178_ChIP-ChIP_JURKAT_Human2.30613997
29SALL1_21062744_ChIP-ChIP_HESCs_Human2.18258449
30FOXM1_23109430_ChIP-Seq_U2OS_Human2.16604392
31TTF2_22483619_ChIP-Seq_HELA_Human2.16236457
32FOXP3_21729870_ChIP-Seq_TREG_Human2.16230306
33THAP11_20581084_ChIP-Seq_MESCs_Mouse2.12581638
34GABP_19822575_ChIP-Seq_HepG2_Human2.11400480
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.95327127
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94522936
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.93062152
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.89856219
39* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.88677443
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.87943823
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.87783069
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.82872066
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.78895173
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.72755923
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.65149429
46* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.64025055
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.63232249
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58796305
49EWS_26573619_Chip-Seq_HEK293_Human1.58005629
50TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.53222547
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.52864953
52PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.51498909
53NANOG_18555785_ChIP-Seq_MESCs_Mouse1.49934108
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48947001
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48520183
56ELK1_22589737_ChIP-Seq_MCF10A_Human1.45836635
57FUS_26573619_Chip-Seq_HEK293_Human1.44603507
58PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.43088132
59AR_21909140_ChIP-Seq_LNCAP_Human1.42268008
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.36405477
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.31701162
62NANOG_16153702_ChIP-ChIP_HESCs_Human1.30670879
63* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30191654
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27557763
65KDM5A_27292631_Chip-Seq_BREAST_Human1.27259137
66CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.23947874
67MYC_18940864_ChIP-ChIP_HL60_Human1.23844185
68TFEB_21752829_ChIP-Seq_HELA_Human1.23335898
69RBPJ_22232070_ChIP-Seq_NCS_Mouse1.21901923
70KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.21043042
71POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19719623
72ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.18157188
73IGF1R_20145208_ChIP-Seq_DFB_Human1.17350145
74NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.14464429
75* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.13321530
76BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12086673
77SOX2_16153702_ChIP-ChIP_HESCs_Human1.11962860
78KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11939802
79SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11778605
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.10119761
81SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.06915224
82CIITA_25753668_ChIP-Seq_RAJI_Human1.06458612
83STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06181586
84CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04645752
85* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02692393
86CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.02572429
87HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.99626017
88GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97838550
89SPI1_23547873_ChIP-Seq_NB4_Human0.96885973
90KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94706088
91ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.94352227
92IRF8_21731497_ChIP-ChIP_J774_Mouse0.93513656
93HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93007782
94HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.92548614
95POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90454430
96SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.90381093
97TP63_19390658_ChIP-ChIP_HaCaT_Human0.89387192
98ZNF274_21170338_ChIP-Seq_K562_Hela0.88543854
99IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.88359170
100* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.87794402
101POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.86887882
102VDR_22108803_ChIP-Seq_LS180_Human0.86238091
103CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.86055415
104SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.84444041
105SOX17_20123909_ChIP-Seq_XEN_Mouse0.83394772
106* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.83315725
107ESR1_15608294_ChIP-ChIP_MCF-7_Human0.83297340
108SOX2_18555785_ChIP-Seq_MESCs_Mouse0.82645449
109TAF15_26573619_Chip-Seq_HEK293_Human0.82091714
110TCF3_18692474_ChIP-Seq_MEFs_Mouse0.82021221
111FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.81716811
112FLI1_27457419_Chip-Seq_LIVER_Mouse0.81697375
113FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79736228
114CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.79175277
115RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.77674674
116* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.76746291
117DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.76724155
118NANOG_21062744_ChIP-ChIP_HESCs_Human0.76495718
119ELF5_23300383_ChIP-Seq_T47D_Human0.76142479
120OCT4_18692474_ChIP-Seq_MEFs_Mouse0.76122239
121KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.75052349
122EGR1_19374776_ChIP-ChIP_THP-1_Human0.74423361
123SOX2_18692474_ChIP-Seq_MEFs_Mouse0.73954139
124* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.70663321
125NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.68485530
126KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.68215893

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.62764880
2MP0004957_abnormal_blastocyst_morpholog4.57572252
3MP0010094_abnormal_chromosome_stability3.93763893
4MP0008058_abnormal_DNA_repair3.77876269
5MP0008057_abnormal_DNA_replication3.64487824
6MP0003111_abnormal_nucleus_morphology3.62076615
7MP0003077_abnormal_cell_cycle3.54514837
8MP0008932_abnormal_embryonic_tissue3.19296580
9MP0009379_abnormal_foot_pigmentation2.95379212
10MP0003123_paternal_imprinting2.76980539
11MP0008877_abnormal_DNA_methylation2.54846953
12MP0008007_abnormal_cellular_replicative2.54357173
13MP0003786_premature_aging2.35601515
14MP0003186_abnormal_redox_activity2.31282117
15MP0003718_maternal_effect2.17102247
16MP0001730_embryonic_growth_arrest1.88445234
17MP0003806_abnormal_nucleotide_metabolis1.86775585
18MP0003937_abnormal_limbs/digits/tail_de1.80939715
19MP0000350_abnormal_cell_proliferation1.71184901
20MP0010352_gastrointestinal_tract_polyps1.64412718
21MP0009333_abnormal_splenocyte_physiolog1.60076122
22MP0009785_altered_susceptibility_to1.55491724
23MP0006072_abnormal_retinal_apoptosis1.54951325
24MP0002210_abnormal_sex_determination1.47749845
25MP0001529_abnormal_vocalization1.46661911
26MP0002148_abnormal_hypersensitivity_rea1.42978029
27MP0001188_hyperpigmentation1.42685793
28MP0001853_heart_inflammation1.40764182
29MP0003136_yellow_coat_color1.39972813
30MP0000537_abnormal_urethra_morphology1.39774945
31MP0000313_abnormal_cell_death1.38453178
32MP0000490_abnormal_crypts_of1.35140490
33MP0006036_abnormal_mitochondrial_physio1.34750734
34MP0001697_abnormal_embryo_size1.34336658
35MP0009672_abnormal_birth_weight1.33203837
36MP0001286_abnormal_eye_development1.33010104
37MP0002102_abnormal_ear_morphology1.27881686
38MP0002697_abnormal_eye_size1.27870491
39MP0002234_abnormal_pharynx_morphology1.27057671
40MP0003119_abnormal_digestive_system1.25917787
41MP0001145_abnormal_male_reproductive1.24203859
42MP0002396_abnormal_hematopoietic_system1.23750512
43MP0002019_abnormal_tumor_incidence1.22455534
44MP0002233_abnormal_nose_morphology1.20926638
45MP0006292_abnormal_olfactory_placode1.20529626
46MP0008789_abnormal_olfactory_epithelium1.20422661
47MP0004133_heterotaxia1.18893616
48MP0000358_abnormal_cell_content/1.17512334
49MP0006035_abnormal_mitochondrial_morpho1.16156927
50MP0001835_abnormal_antigen_presentation1.15902274
51MP0002080_prenatal_lethality1.15250337
52MP0002277_abnormal_respiratory_mucosa1.14752718
53MP0003315_abnormal_perineum_morphology1.13534913
54MP0002638_abnormal_pupillary_reflex1.12872523
55MP0003941_abnormal_skin_development1.12063005
56MP0002938_white_spotting1.11586003
57MP0002163_abnormal_gland_morphology1.09916455
58MP0002796_impaired_skin_barrier1.07912378
59MP0010030_abnormal_orbit_morphology1.07865466
60MP0000858_altered_metastatic_potential1.07633755
61MP0005380_embryogenesis_phenotype1.07575446
62MP0001672_abnormal_embryogenesis/_devel1.07575446
63MP0000647_abnormal_sebaceous_gland1.07240050
64MP0000750_abnormal_muscle_regeneration1.06205643
65MP0003221_abnormal_cardiomyocyte_apopto1.06174696
66MP0005000_abnormal_immune_tolerance1.05790039
67MP0003567_abnormal_fetal_cardiomyocyte1.05767841
68MP0002111_abnormal_tail_morphology1.05192829
69MP0002132_abnormal_respiratory_system1.03578376
70MP0000762_abnormal_tongue_morphology1.02665829
71MP0000653_abnormal_sex_gland1.01678105
72MP0010307_abnormal_tumor_latency1.01601477
73MP0003890_abnormal_embryonic-extraembry1.00888371
74MP0002160_abnormal_reproductive_system1.00579381
75MP0001929_abnormal_gametogenesis1.00065729
76MP0002085_abnormal_embryonic_tissue0.97363329
77MP0000049_abnormal_middle_ear0.97336159
78MP0003755_abnormal_palate_morphology0.96036696
79MP0000372_irregular_coat_pigmentation0.94114231
80MP0005501_abnormal_skin_physiology0.93695174
81MP0001299_abnormal_eye_distance/0.92862746
82MP0004808_abnormal_hematopoietic_stem0.91900046
83MP0005025_abnormal_response_to0.91379430
84MP0008260_abnormal_autophagy0.91184242
85MP0005671_abnormal_response_to0.90583466
86MP0002751_abnormal_autonomic_nervous0.90316134
87MP0009703_decreased_birth_body0.90265464
88MP0003763_abnormal_thymus_physiology0.88144513
89MP0002398_abnormal_bone_marrow0.87475410
90MP0005499_abnormal_olfactory_system0.87304059
91MP0005394_taste/olfaction_phenotype0.87304059
92MP0000579_abnormal_nail_morphology0.86538342
93MP0005389_reproductive_system_phenotype0.86336697
94MP0003121_genomic_imprinting0.86324473
95MP0003984_embryonic_growth_retardation0.85797922
96MP0005187_abnormal_penis_morphology0.84819854
97MP0002009_preneoplasia0.82700038
98MP0003724_increased_susceptibility_to0.82657975
99MP0001119_abnormal_female_reproductive0.82636017
100MP0002088_abnormal_embryonic_growth/wei0.81728620
101MP0003861_abnormal_nervous_system0.81288768
102MP0002092_abnormal_eye_morphology0.80713498
103MP0001727_abnormal_embryo_implantation0.80398548
104MP0002722_abnormal_immune_system0.80265863
105MP0003385_abnormal_body_wall0.79194930
106MP0002723_abnormal_immune_serum0.79089661
107MP0000703_abnormal_thymus_morphology0.79019493
108MP0008995_early_reproductive_senescence0.78954392
109MP0003448_altered_tumor_morphology0.78880784
110MP0002877_abnormal_melanocyte_morpholog0.78664915
111MP0001905_abnormal_dopamine_level0.78050959
112MP0001293_anophthalmia0.77858544
113MP0000689_abnormal_spleen_morphology0.77764028
114MP0002084_abnormal_developmental_patter0.77650003
115MP0001346_abnormal_lacrimal_gland0.76748404
116MP0002452_abnormal_antigen_presenting0.76732866
117MP0000343_altered_response_to0.76306544
118MP0004197_abnormal_fetal_growth/weight/0.75735291
119MP0002405_respiratory_system_inflammati0.74376072
120MP0005384_cellular_phenotype0.73496711
121MP0002429_abnormal_blood_cell0.73477732
122MP0001177_atelectasis0.73413206
123MP0005084_abnormal_gallbladder_morpholo0.72999778
124MP0009250_abnormal_appendicular_skeleto0.72829190
125MP0005391_vision/eye_phenotype0.72493847
126MP0005266_abnormal_metabolism0.72017845
127MP0006082_CNS_inflammation0.71156835
128MP0005379_endocrine/exocrine_gland_phen0.70962177
129MP0001819_abnormal_immune_cell0.70638414
130MP0001764_abnormal_homeostasis0.70359819
131MP0003436_decreased_susceptibility_to0.70351604
132MP0003935_abnormal_craniofacial_develop0.69948590
133MP0000428_abnormal_craniofacial_morphol0.69887284
134MP0009697_abnormal_copulation0.69557267
135MP0002420_abnormal_adaptive_immunity0.68830526
136MP0000716_abnormal_immune_system0.67954262
137MP0002736_abnormal_nociception_after0.67866894
138MP0002086_abnormal_extraembryonic_tissu0.67540187
139MP0002419_abnormal_innate_immunity0.65717677
140MP0001340_abnormal_eyelid_morphology0.64445388
141MP0001881_abnormal_mammary_gland0.64194797
142MP0002177_abnormal_outer_ear0.64062362
143MP0002081_perinatal_lethality0.63101353
144MP0004272_abnormal_basement_membrane0.62940838

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.12678906
2Reticulocytopenia (HP:0001896)4.97447702
3Abnormal number of erythroid precursors (HP:0012131)4.66247468
4Acute necrotizing encephalopathy (HP:0006965)4.57549763
5Mitochondrial inheritance (HP:0001427)4.23783493
6Increased hepatocellular lipid droplets (HP:0006565)4.09553292
7Abnormal mitochondria in muscle tissue (HP:0008316)4.09393953
8Birth length less than 3rd percentile (HP:0003561)4.08911660
9Increased CSF lactate (HP:0002490)3.77315544
10Pallor (HP:0000980)3.72241097
11Hepatocellular necrosis (HP:0001404)3.71450003
12Macrocytic anemia (HP:0001972)3.71060065
13Progressive macrocephaly (HP:0004481)3.58677020
14Decreased activity of mitochondrial respiratory chain (HP:0008972)3.55400427
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.55400427
16Aplastic anemia (HP:0001915)3.52424298
17Acute encephalopathy (HP:0006846)3.50519931
18Lipid accumulation in hepatocytes (HP:0006561)3.47982266
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.42100014
20Oral leukoplakia (HP:0002745)3.39567365
21Exertional dyspnea (HP:0002875)3.37693031
22Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.33412827
23Hepatic necrosis (HP:0002605)3.24368049
24Breast hypoplasia (HP:0003187)3.21609033
25Rough bone trabeculation (HP:0100670)3.19149994
26Increased serum lactate (HP:0002151)3.13286084
273-Methylglutaconic aciduria (HP:0003535)3.11723157
28Cerebral hypomyelination (HP:0006808)3.00400154
29Abnormal lung lobation (HP:0002101)2.95968841
30Exercise intolerance (HP:0003546)2.94392483
31Colon cancer (HP:0003003)2.92270585
32Renal Fanconi syndrome (HP:0001994)2.89125771
33Aplasia/Hypoplasia of the sacrum (HP:0008517)2.83093440
34Carpal bone hypoplasia (HP:0001498)2.82667677
35Volvulus (HP:0002580)2.80509912
36Increased intramyocellular lipid droplets (HP:0012240)2.79051006
37Abnormality of glycolysis (HP:0004366)2.77348157
38Increased serum pyruvate (HP:0003542)2.77348157
39Abnormality of the labia minora (HP:0012880)2.70094726
40Poor head control (HP:0002421)2.67996457
41Trismus (HP:0000211)2.67503208
42Cortical dysplasia (HP:0002539)2.66812272
43Premature graying of hair (HP:0002216)2.64649195
44Aplasia/Hypoplasia of the uvula (HP:0010293)2.59474185
45Cleft eyelid (HP:0000625)2.58461498
46Chromsome breakage (HP:0040012)2.54851065
47Abnormal trabecular bone morphology (HP:0100671)2.49126150
48Degeneration of anterior horn cells (HP:0002398)2.48635624
49Abnormality of the anterior horn cell (HP:0006802)2.48635624
50Chromosomal breakage induced by crosslinking agents (HP:0003221)2.48123339
51Respiratory failure (HP:0002878)2.46851934
52Absent thumb (HP:0009777)2.44602886
53Respiratory difficulties (HP:0002880)2.44102422
54Microretrognathia (HP:0000308)2.42744419
55Patellar aplasia (HP:0006443)2.42278888
56Small intestinal stenosis (HP:0012848)2.41026642
57Duodenal stenosis (HP:0100867)2.41026642
58Lactic acidosis (HP:0003128)2.40772066
59Absent radius (HP:0003974)2.38857789
60Abnormality of the preputium (HP:0100587)2.35229801
61Abnormality of methionine metabolism (HP:0010901)2.34621800
62Secondary amenorrhea (HP:0000869)2.34522981
63Aplasia/Hypoplasia of the patella (HP:0006498)2.29325116
6411 pairs of ribs (HP:0000878)2.28360789
65Pancytopenia (HP:0001876)2.27275424
66Nephroblastoma (Wilms tumor) (HP:0002667)2.26687965
67Horseshoe kidney (HP:0000085)2.25614047
68Embryonal renal neoplasm (HP:0011794)2.25154054
69Type I transferrin isoform profile (HP:0003642)2.24372578
70Agnosia (HP:0010524)2.23490875
71Abnormality of serum amino acid levels (HP:0003112)2.22635911
72Cerebral edema (HP:0002181)2.22418442
73Absent forearm bone (HP:0003953)2.21102140
74Aplasia involving forearm bones (HP:0009822)2.21102140
75Meckel diverticulum (HP:0002245)2.19630162
76Facial cleft (HP:0002006)2.18168179
77Selective tooth agenesis (HP:0001592)2.18159342
78Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.17740848
79Supernumerary spleens (HP:0009799)2.17062927
80Stenosis of the external auditory canal (HP:0000402)2.13407769
81Reduced antithrombin III activity (HP:0001976)2.13117626
82Abnormality of the duodenum (HP:0002246)2.12606240
83Abnormality of the ileum (HP:0001549)2.12453720
84Increased muscle lipid content (HP:0009058)2.12226908
85Medulloblastoma (HP:0002885)2.11193953
86Abnormality of chromosome stability (HP:0003220)2.10229871
87Premature ovarian failure (HP:0008209)2.09337534
88Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.07284925
89Abnormality of alanine metabolism (HP:0010916)2.07284925
90Hyperalaninemia (HP:0003348)2.07284925
91Microvesicular hepatic steatosis (HP:0001414)2.07229809
92Shoulder girdle muscle weakness (HP:0003547)2.04516121
93Cellular immunodeficiency (HP:0005374)2.03932243
94Methylmalonic acidemia (HP:0002912)2.02526447
95Leukodystrophy (HP:0002415)2.02368684
96Bone marrow hypocellularity (HP:0005528)2.01976588
97Multiple enchondromatosis (HP:0005701)2.01288794
98Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.01154568
99Abnormal protein N-linked glycosylation (HP:0012347)2.01154568
100Abnormal protein glycosylation (HP:0012346)2.01154568
101Abnormal glycosylation (HP:0012345)2.01154568
102Myelodysplasia (HP:0002863)2.00573004
103Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.99899739
104Glossoptosis (HP:0000162)1.99751712
105Neoplasm of the pancreas (HP:0002894)1.99342549
106Triphalangeal thumb (HP:0001199)1.98928781
107Ependymoma (HP:0002888)1.98571149
108CNS demyelination (HP:0007305)1.96832474
109Abnormal hemoglobin (HP:0011902)1.96690179
110Increased nuchal translucency (HP:0010880)1.96274307
111CNS hypomyelination (HP:0003429)1.96120544
112Abnormality of aspartate family amino acid metabolism (HP:0010899)1.95527984
113Emotional lability (HP:0000712)1.95376399
114Megaloblastic anemia (HP:0001889)1.95309761
115Optic disc pallor (HP:0000543)1.92634582
116Spastic diplegia (HP:0001264)1.89636707
117Hyperglycinemia (HP:0002154)1.88480718
118Congenital, generalized hypertrichosis (HP:0004540)1.88176609
119Abnormal spermatogenesis (HP:0008669)1.84714146
120Exercise-induced muscle cramps (HP:0003710)1.84151784
121Rhabdomyosarcoma (HP:0002859)1.83898890
122Duplicated collecting system (HP:0000081)1.83071147
123Bifid tongue (HP:0010297)1.82464462
124Postnatal microcephaly (HP:0005484)1.81038286
125Aplasia/hypoplasia of the uterus (HP:0008684)1.80669992
126Neoplasm of the colon (HP:0100273)1.80488663
127Sloping forehead (HP:0000340)1.79888229
128Abnormality of placental membranes (HP:0011409)1.79603277
129Amniotic constriction ring (HP:0009775)1.79603277
130Irregular epiphyses (HP:0010582)1.77185504
131Abnormality of the carotid arteries (HP:0005344)1.76742792
132Bilateral microphthalmos (HP:0007633)1.76487335
133Pulmonary fibrosis (HP:0002206)1.74916358
134Abnormality of the septum pellucidum (HP:0007375)1.74021874
135Increased IgM level (HP:0003496)1.73579512
136Proximal placement of thumb (HP:0009623)1.72904238
137Sparse eyelashes (HP:0000653)1.72903071
138Tracheoesophageal fistula (HP:0002575)1.72056130
139Abnormality of the hip-girdle musculature (HP:0001445)1.71937737
140Abnormality of the musculature of the pelvis (HP:0001469)1.71937737
141Abnormality of the umbilical cord (HP:0010881)1.71696791
142Neoplasm of the adrenal gland (HP:0100631)1.69708012
143Abnormality of the fetal cardiovascular system (HP:0010948)1.69660522
144Abnormal umbilical cord blood vessels (HP:0011403)1.69660522
145Single umbilical artery (HP:0001195)1.69660522
146Myelomeningocele (HP:0002475)1.66047988
147Median cleft lip (HP:0000161)1.65768174
148Absent septum pellucidum (HP:0001331)1.65368569

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.28112224
2EIF2AK13.97363135
3WEE13.77109783
4NME23.76316962
5PBK3.54280810
6STK163.52841904
7VRK23.07620187
8EIF2AK32.96640934
9CDC72.72636840
10TRIM282.66499227
11SRPK12.65982069
12ACVR1B2.33708297
13PLK42.29910921
14TESK22.23037166
15MKNK12.17789800
16VRK12.13144298
17NME12.04573492
18PIM21.85718550
19TLK11.81520005
20BRSK21.73611045
21TAF11.64114414
22TESK11.59939995
23DYRK31.59284275
24PLK11.59200723
25MKNK21.54411807
26PASK1.52046020
27NUAK11.49712559
28LIMK11.41049291
29TTK1.40292864
30TSSK61.30139941
31MST41.24626068
32PLK31.24487223
33AURKB1.24436492
34AURKA1.22916544
35TNIK1.21868425
36RPS6KA41.20790964
37CDK71.17239419
38IRAK31.17151177
39EIF2AK21.11957546
40CSNK1G11.10027931
41MAP2K71.08617305
42IRAK41.06554717
43NEK21.06309623
44ATR1.04470223
45DYRK21.03523134
46SCYL20.99743373
47MAP3K40.96746296
48MAP4K20.95894940
49NEK10.94431193
50WNK30.94205507
51PNCK0.93773649
52BLK0.92751644
53ARAF0.90407572
54ERBB40.89482927
55CSNK1G20.88473887
56RPS6KB20.86983913
57ZAK0.86553604
58EPHA20.85119336
59CSNK1A1L0.82927318
60BRSK10.80607583
61BRAF0.80009326
62CCNB10.79420343
63KDR0.78922565
64ABL20.78898838
65CSNK2A10.78462268
66STK30.78408155
67CSNK2A20.77715351
68FLT30.76225211
69ALK0.75164575
70CHEK20.73607226
71PLK20.72667703
72MAP3K110.70836550
73BMPR1B0.67216338
74TGFBR10.66877689
75CHEK10.65595968
76GRK70.64646215
77RPS6KA50.64457600
78MAPKAPK30.64452914
79PAK10.64278800
80CDK190.63579022
81MAP3K120.60233946
82STK40.59677558
83LATS10.58836986
84MAP3K80.57170954
85BRD40.56630667
86CLK10.54566762
87SIK30.53651619
88CDK80.52155644
89FGFR10.50189292
90CDK30.49522627
91MAP3K50.49317770
92ATM0.49177670
93PRKCI0.47351111
94BCR0.46797092
95MAP3K100.45527293
96PIM10.43041971
97CDK20.42549899
98CDK40.42383342
99IRAK10.41991099
100PAK40.41870699
101ERBB30.41528741
102RIPK40.39484144
103CDK60.39303752
104DAPK30.39148518
105MINK10.38541961
106CDK180.38158962
107MELK0.38134329
108CDK140.37829297
109LATS20.37080881
110NLK0.36876419
111STK240.36218734
112STK38L0.35581550
113PDK20.35123718
114STK390.34595556
115IKBKB0.34127420
116MAP3K30.33704160
117YES10.31905806
118TEC0.31524190
119BCKDK0.31085094
120CDK10.30931296
121ADRBK20.30670666
122CDK11A0.30537252
123CSNK1G30.29025260
124CDK150.28511920
125OXSR10.28444319
126LYN0.28063080
127CSNK1A10.26712571
128CSNK1E0.24805576
129ILK0.24205016
130DAPK10.23256400
131ADRBK10.22254788
132PIK3CG0.21970407
133MUSK0.21942152
134TBK10.19960819

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.84989856
2Ribosome_Homo sapiens_hsa030104.67844012
3DNA replication_Homo sapiens_hsa030303.72534590
4RNA polymerase_Homo sapiens_hsa030203.69600426
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.55135700
6Mismatch repair_Homo sapiens_hsa034303.34157777
7Spliceosome_Homo sapiens_hsa030403.08633420
8Oxidative phosphorylation_Homo sapiens_hsa001902.66932481
9RNA transport_Homo sapiens_hsa030132.60879434
10Pyrimidine metabolism_Homo sapiens_hsa002402.53970917
11Homologous recombination_Homo sapiens_hsa034402.52837941
12Protein export_Homo sapiens_hsa030602.48745594
13Parkinsons disease_Homo sapiens_hsa050122.40597287
14Nucleotide excision repair_Homo sapiens_hsa034202.40554534
15Basal transcription factors_Homo sapiens_hsa030222.03332342
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.02883258
17Base excision repair_Homo sapiens_hsa034102.02276964
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.00590846
19Huntingtons disease_Homo sapiens_hsa050162.00071054
20Cell cycle_Homo sapiens_hsa041101.78067508
21One carbon pool by folate_Homo sapiens_hsa006701.72344383
22Non-homologous end-joining_Homo sapiens_hsa034501.64341828
23Fanconi anemia pathway_Homo sapiens_hsa034601.62581480
24RNA degradation_Homo sapiens_hsa030181.60202282
25Alzheimers disease_Homo sapiens_hsa050101.56444875
26Steroid biosynthesis_Homo sapiens_hsa001001.50217331
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.46003854
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.43822829
29Pyruvate metabolism_Homo sapiens_hsa006201.39619354
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38862729
31Propanoate metabolism_Homo sapiens_hsa006401.38148547
32Purine metabolism_Homo sapiens_hsa002301.29349790
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.23445984
34Epstein-Barr virus infection_Homo sapiens_hsa051691.20565733
35Fatty acid elongation_Homo sapiens_hsa000621.18844101
36mRNA surveillance pathway_Homo sapiens_hsa030151.13545456
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.11367832
38p53 signaling pathway_Homo sapiens_hsa041151.10717017
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.09497921
40Carbon metabolism_Homo sapiens_hsa012001.07199569
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.04785578
42Folate biosynthesis_Homo sapiens_hsa007900.99275913
43Graft-versus-host disease_Homo sapiens_hsa053320.98487616
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94369275
45Legionellosis_Homo sapiens_hsa051340.93444911
46Allograft rejection_Homo sapiens_hsa053300.91253020
47Herpes simplex infection_Homo sapiens_hsa051680.89621842
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89016701
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78211454
50Systemic lupus erythematosus_Homo sapiens_hsa053220.76739356
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76021302
52Type I diabetes mellitus_Homo sapiens_hsa049400.74970376
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.74647240
54Vitamin B6 metabolism_Homo sapiens_hsa007500.71939305
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67397661
56Asthma_Homo sapiens_hsa053100.67132137
57Cardiac muscle contraction_Homo sapiens_hsa042600.64503379
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59339550
59Glutathione metabolism_Homo sapiens_hsa004800.59082075
60Hippo signaling pathway_Homo sapiens_hsa043900.54852210
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54270541
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53929998
63Antigen processing and presentation_Homo sapiens_hsa046120.53810752
64Oocyte meiosis_Homo sapiens_hsa041140.53608102
65NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52788468
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.52760009
67Viral carcinogenesis_Homo sapiens_hsa052030.50638871
68Rheumatoid arthritis_Homo sapiens_hsa053230.50019633
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48262000
70Sulfur relay system_Homo sapiens_hsa041220.47981725
71Shigellosis_Homo sapiens_hsa051310.46913378
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43906911
73NF-kappa B signaling pathway_Homo sapiens_hsa040640.42642867
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41432049
75RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41419010
76Pertussis_Homo sapiens_hsa051330.41388100
77Butanoate metabolism_Homo sapiens_hsa006500.41247585
78Measles_Homo sapiens_hsa051620.41242240
79Wnt signaling pathway_Homo sapiens_hsa043100.41065172
80Metabolic pathways_Homo sapiens_hsa011000.40338422
81Phagosome_Homo sapiens_hsa041450.39928392
82Fatty acid metabolism_Homo sapiens_hsa012120.38378759
83Arginine and proline metabolism_Homo sapiens_hsa003300.38296018
84Sulfur metabolism_Homo sapiens_hsa009200.38176731
85Arachidonic acid metabolism_Homo sapiens_hsa005900.38142357
86Vibrio cholerae infection_Homo sapiens_hsa051100.38020727
87Basal cell carcinoma_Homo sapiens_hsa052170.37797618
88Autoimmune thyroid disease_Homo sapiens_hsa053200.37310419
89Hematopoietic cell lineage_Homo sapiens_hsa046400.35845461
90Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35562077
91Leishmaniasis_Homo sapiens_hsa051400.35520166
92Influenza A_Homo sapiens_hsa051640.34980515
93HTLV-I infection_Homo sapiens_hsa051660.34343715
94Selenocompound metabolism_Homo sapiens_hsa004500.34128735
95Pentose phosphate pathway_Homo sapiens_hsa000300.34010868
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33570460
97Malaria_Homo sapiens_hsa051440.33509074
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33464031
99Peroxisome_Homo sapiens_hsa041460.33360541
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.32737493
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32010548
102Intestinal immune network for IgA production_Homo sapiens_hsa046720.31530942
103Apoptosis_Homo sapiens_hsa042100.30339919
104Collecting duct acid secretion_Homo sapiens_hsa049660.28873404
105Hedgehog signaling pathway_Homo sapiens_hsa043400.27180043
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26939537
107Regulation of autophagy_Homo sapiens_hsa041400.26443434
108Cyanoamino acid metabolism_Homo sapiens_hsa004600.26434097
109Salmonella infection_Homo sapiens_hsa051320.25991854
110Tight junction_Homo sapiens_hsa045300.25736191
111Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.24882866
112beta-Alanine metabolism_Homo sapiens_hsa004100.23595127
113Alcoholism_Homo sapiens_hsa050340.22376829
114Adherens junction_Homo sapiens_hsa045200.22276617
115Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.21970661
116Phototransduction_Homo sapiens_hsa047440.21562016
117African trypanosomiasis_Homo sapiens_hsa051430.21465047
118Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.20925543
119N-Glycan biosynthesis_Homo sapiens_hsa005100.20776664
120Thyroid cancer_Homo sapiens_hsa052160.19664936
121Primary immunodeficiency_Homo sapiens_hsa053400.19496193
122Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.18031972
123Toll-like receptor signaling pathway_Homo sapiens_hsa046200.16384946
124Central carbon metabolism in cancer_Homo sapiens_hsa052300.15126270
125TGF-beta signaling pathway_Homo sapiens_hsa043500.14697556
126Biosynthesis of amino acids_Homo sapiens_hsa012300.13960616
127Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.13900287
128Lysine degradation_Homo sapiens_hsa003100.13852631
129Other glycan degradation_Homo sapiens_hsa005110.12854549
130Hepatitis B_Homo sapiens_hsa051610.12553434
131Tuberculosis_Homo sapiens_hsa051520.12453794
132Linoleic acid metabolism_Homo sapiens_hsa005910.12059665
133Colorectal cancer_Homo sapiens_hsa052100.11905650
134Vitamin digestion and absorption_Homo sapiens_hsa049770.11577944
135MicroRNAs in cancer_Homo sapiens_hsa052060.10898114
136Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.10580444
137Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.09510413
138Galactose metabolism_Homo sapiens_hsa000520.08959228
139Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.05281409
140Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.04786046
141Fatty acid degradation_Homo sapiens_hsa000710.03606156

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