DEPDC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid segregation (GO:0000070)6.50877655
2sister chromatid segregation (GO:0000819)6.32352887
3nuclear pore complex assembly (GO:0051292)6.08195722
4protein localization to kinetochore (GO:0034501)6.07557041
5regulation of attachment of spindle microtubules to kinetochore (GO:0051988)6.03486718
6mitotic chromosome condensation (GO:0007076)6.03326297
7mitotic metaphase plate congression (GO:0007080)6.01146457
8protein localization to chromosome, centromeric region (GO:0071459)5.77043662
9nuclear pore organization (GO:0006999)5.42880589
10metaphase plate congression (GO:0051310)5.33669153
11kinetochore organization (GO:0051383)5.20802664
12regulation of mitotic spindle organization (GO:0060236)5.19264451
13CENP-A containing nucleosome assembly (GO:0034080)5.07567392
14regulation of spindle organization (GO:0090224)5.02528845
15DNA unwinding involved in DNA replication (GO:0006268)4.97464067
16chromatin remodeling at centromere (GO:0031055)4.96298310
17establishment of chromosome localization (GO:0051303)4.63786612
18mitotic sister chromatid cohesion (GO:0007064)4.59686158
19spindle checkpoint (GO:0031577)4.54979128
20pore complex assembly (GO:0046931)4.47830059
21regulation of chromosome segregation (GO:0051983)4.46874862
22DNA strand elongation involved in DNA replication (GO:0006271)4.43651785
23establishment of integrated proviral latency (GO:0075713)4.34939332
24DNA topological change (GO:0006265)4.32069124
25mitotic nuclear envelope disassembly (GO:0007077)4.31631072
26negative regulation of chromosome segregation (GO:0051985)4.31262644
27DNA ligation (GO:0006266)4.30579596
28mitotic spindle checkpoint (GO:0071174)4.29372167
29kinetochore assembly (GO:0051382)4.28950551
30DNA strand elongation (GO:0022616)4.28783307
31negative regulation of mitotic sister chromatid separation (GO:2000816)4.23176132
32negative regulation of sister chromatid segregation (GO:0033046)4.23176132
33negative regulation of mitotic metaphase/anaphase transition (GO:0045841)4.23176132
34negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)4.23176132
35negative regulation of mitotic sister chromatid segregation (GO:0033048)4.23176132
36chromosome condensation (GO:0030261)4.20835530
37histone exchange (GO:0043486)4.19181650
38telomere maintenance via semi-conservative replication (GO:0032201)4.15496007
39mitotic spindle assembly checkpoint (GO:0007094)4.12604574
40regulation of mitotic metaphase/anaphase transition (GO:0030071)4.11818694
41regulation of metaphase/anaphase transition of cell cycle (GO:1902099)4.11818694
42spindle assembly checkpoint (GO:0071173)4.09954411
43DNA replication-independent nucleosome organization (GO:0034724)4.06335691
44DNA replication-independent nucleosome assembly (GO:0006336)4.06335691
45DNA replication checkpoint (GO:0000076)4.04093327
46membrane disassembly (GO:0030397)4.03950264
47nuclear envelope disassembly (GO:0051081)4.03950264
48positive regulation of chromosome segregation (GO:0051984)4.02862971
49regulation of centriole replication (GO:0046599)4.01605337
50chromosome segregation (GO:0007059)4.01092864
51regulation of mitotic sister chromatid segregation (GO:0033047)4.01043114
52regulation of sister chromatid segregation (GO:0033045)4.01043114
53regulation of mitotic sister chromatid separation (GO:0010965)4.01043114
54protein localization to chromosome (GO:0034502)3.78139928
55mitotic recombination (GO:0006312)3.77683539
56DNA packaging (GO:0006323)3.71770428
57attachment of spindle microtubules to kinetochore (GO:0008608)3.70342438
58regulation of centrosome cycle (GO:0046605)3.69358141
59microtubule depolymerization (GO:0007019)3.65314771
60meiotic chromosome segregation (GO:0045132)3.61285427
61telomere maintenance via recombination (GO:0000722)3.60439084
62DNA replication initiation (GO:0006270)3.49545357
63regulation of DNA endoreduplication (GO:0032875)3.49515582
64protein complex localization (GO:0031503)3.48636679
65ribosome assembly (GO:0042255)3.45979486
66non-recombinational repair (GO:0000726)3.44074158
67double-strand break repair via nonhomologous end joining (GO:0006303)3.44074158
68ventricular cardiac muscle cell development (GO:0055015)3.42313684
69positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.40553256
70positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.40553256
71positive regulation of mitotic sister chromatid separation (GO:1901970)3.40553256
72regulation of sister chromatid cohesion (GO:0007063)3.40354163
73negative regulation of mitosis (GO:0045839)3.37266990
74mitotic G2/M transition checkpoint (GO:0044818)3.35335119
75ATP-dependent chromatin remodeling (GO:0043044)3.30034246
76regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.29318309
77chromatin assembly or disassembly (GO:0006333)3.26377140
78establishment of viral latency (GO:0019043)3.23619430
79purine nucleobase biosynthetic process (GO:0009113)3.21222981
80cellular protein complex localization (GO:0034629)3.18707591
81heterochromatin organization (GO:0070828)3.18692495
82DNA conformation change (GO:0071103)3.17667726
83anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.17318158
84regulation of centrosome duplication (GO:0010824)3.16782543
85histone-serine phosphorylation (GO:0035404)3.16463491
86mitotic cell cycle (GO:0000278)3.16372465
87mitotic spindle organization (GO:0007052)3.14371953
88nuclear envelope organization (GO:0006998)3.12880494
89IMP biosynthetic process (GO:0006188)3.12713300
90DNA duplex unwinding (GO:0032508)3.10911430
91mitotic cytokinesis (GO:0000281)3.10199169
92DNA replication-dependent nucleosome assembly (GO:0006335)3.05703990
93DNA replication-dependent nucleosome organization (GO:0034723)3.05703990
94DNA geometric change (GO:0032392)3.03565284
95negative regulation of DNA repair (GO:0045738)3.02156926
96negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)3.00787920
97nucleotide-excision repair, DNA gap filling (GO:0006297)3.00382064
98nucleobase biosynthetic process (GO:0046112)2.99461691
99regulation of spindle checkpoint (GO:0090231)2.98410945
100negative regulation of cell division (GO:0051782)2.96614219

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.42016278
2* FOXM1_23109430_ChIP-Seq_U2OS_Human7.91066838
3E2F4_17652178_ChIP-ChIP_JURKAT_Human5.21924395
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.85843823
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.89676767
6* AR_21909140_ChIP-Seq_LNCAP_Human3.73965081
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.58128769
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.88937830
9KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.73900207
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.72044783
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.69872485
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.65102102
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.62995401
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.62728581
15E2F1_21310950_ChIP-Seq_MCF-7_Human2.54886894
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.34582695
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.33449139
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.33053290
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.31727226
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.31005407
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.26407215
22SALL1_21062744_ChIP-ChIP_HESCs_Human2.12754461
23ELK1_19687146_ChIP-ChIP_HELA_Human2.12059282
24MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.08389891
25MYCN_18555785_ChIP-Seq_MESCs_Mouse2.07385613
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.99798573
27XRN2_22483619_ChIP-Seq_HELA_Human1.98485750
28DCP1A_22483619_ChIP-Seq_HELA_Human1.95624320
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.94369908
30ETS1_20019798_ChIP-Seq_JURKAT_Human1.90444158
31THAP11_20581084_ChIP-Seq_MESCs_Mouse1.85662650
32TTF2_22483619_ChIP-Seq_HELA_Human1.85176676
33E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81954909
34YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80535002
35ZFX_18555785_ChIP-Seq_MESCs_Mouse1.72492462
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.69511748
37PADI4_21655091_ChIP-ChIP_MCF-7_Human1.63727707
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.62656790
39PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.54012772
40FOXP3_21729870_ChIP-Seq_TREG_Human1.51492862
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.45652864
42VDR_23849224_ChIP-Seq_CD4+_Human1.43878811
43EGR1_19374776_ChIP-ChIP_THP-1_Human1.41741539
44GABP_19822575_ChIP-Seq_HepG2_Human1.38529128
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38249939
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37854548
47* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.37263105
48CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.32750371
49NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.29871241
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.24294490
51KDM5A_27292631_Chip-Seq_BREAST_Human1.22938773
52SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.18992913
53TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.17283619
54POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.16816119
55SOX17_20123909_ChIP-Seq_XEN_Mouse1.14546242
56SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14397670
57MYC_18940864_ChIP-ChIP_HL60_Human1.12800056
58CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11863115
59KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08660485
60NANOG_16153702_ChIP-ChIP_HESCs_Human1.07310496
61CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06305292
62POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04650117
63CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03560538
64ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03337158
65DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01563923
66ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00664157
67SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.00071085
68E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.97173027
69HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.97026316
70SOX2_16153702_ChIP-ChIP_HESCs_Human0.95576085
71RBPJ_22232070_ChIP-Seq_NCS_Mouse0.95320548
72ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94466437
73TP63_19390658_ChIP-ChIP_HaCaT_Human0.92488697
74* EWS_26573619_Chip-Seq_HEK293_Human0.89945367
75* CHD1_26751641_Chip-Seq_LNCaP_Human0.89053063
76KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88869309
77CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88568459
78NANOG_21062744_ChIP-ChIP_HESCs_Human0.87147709
79TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.87052047
80SRF_21415370_ChIP-Seq_HL-1_Mouse0.86971128
81POU5F1_16153702_ChIP-ChIP_HESCs_Human0.85077413
82* TFEB_21752829_ChIP-Seq_HELA_Human0.82446446
83ELF1_17652178_ChIP-ChIP_JURKAT_Human0.82244909
84STAT3_1855785_ChIP-Seq_MESCs_Mouse0.82186333
85ZNF263_19887448_ChIP-Seq_K562_Human0.81950114
86NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.81865414
87PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.80133835
88ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.78356031
89HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.77338672
90SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.74544262
91DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.73992655
92EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.73142482
93CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.72445843
94HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.72258531
95TCF3_18692474_ChIP-Seq_MEFs_Mouse0.71515392
96TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.70988507
97HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.70000163
98* FUS_26573619_Chip-Seq_HEK293_Human0.68937906
99YY1_21170310_ChIP-Seq_MESCs_Mouse0.68512774
100BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.66745594

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.27641049
2MP0003693_abnormal_embryo_hatching4.87947393
3MP0003111_abnormal_nucleus_morphology4.67201062
4MP0004957_abnormal_blastocyst_morpholog4.16686840
5MP0003077_abnormal_cell_cycle4.08497557
6MP0008057_abnormal_DNA_replication3.92443308
7MP0008058_abnormal_DNA_repair3.35702577
8MP0008932_abnormal_embryonic_tissue3.14956165
9MP0008007_abnormal_cellular_replicative2.89584724
10MP0009697_abnormal_copulation2.46885014
11MP0010352_gastrointestinal_tract_polyps2.30463582
12MP0003941_abnormal_skin_development2.08611287
13MP0000350_abnormal_cell_proliferation2.07505391
14MP0001730_embryonic_growth_arrest2.07289944
15MP0010307_abnormal_tumor_latency1.98337627
16MP0002877_abnormal_melanocyte_morpholog1.98315331
17MP0003890_abnormal_embryonic-extraembry1.97489473
18MP0001672_abnormal_embryogenesis/_devel1.82462422
19MP0005380_embryogenesis_phenotype1.82462422
20MP0001697_abnormal_embryo_size1.77018663
21MP0003718_maternal_effect1.74151721
22MP0003937_abnormal_limbs/digits/tail_de1.71907329
23MP0010030_abnormal_orbit_morphology1.69806779
24MP0001293_anophthalmia1.67288228
25MP0003786_premature_aging1.66435013
26MP0002084_abnormal_developmental_patter1.64479722
27MP0002085_abnormal_embryonic_tissue1.60861383
28MP0003705_abnormal_hypodermis_morpholog1.60046588
29MP0003984_embryonic_growth_retardation1.57226152
30MP0002080_prenatal_lethality1.56238821
31MP0002697_abnormal_eye_size1.53313631
32MP0000537_abnormal_urethra_morphology1.51544964
33MP0002088_abnormal_embryonic_growth/wei1.51504610
34MP0009672_abnormal_birth_weight1.42722165
35MP0005623_abnormal_meninges_morphology1.30437368
36MP0002009_preneoplasia1.29810305
37MP0004197_abnormal_fetal_growth/weight/1.29792102
38MP0000313_abnormal_cell_death1.28881445
39MP0002086_abnormal_extraembryonic_tissu1.25182105
40MP0005076_abnormal_cell_differentiation1.24612607
41MP0006292_abnormal_olfactory_placode1.22665279
42MP0001286_abnormal_eye_development1.19969483
43MP0003806_abnormal_nucleotide_metabolis1.13943038
44MP0002092_abnormal_eye_morphology1.12892125
45MP0002938_white_spotting1.11330164
46MP0002111_abnormal_tail_morphology1.11107288
47MP0004185_abnormal_adipocyte_glucose1.10469756
48MP0010234_abnormal_vibrissa_follicle1.05627329
49MP0002396_abnormal_hematopoietic_system1.05100029
50MP0009053_abnormal_anal_canal1.04806107
51MP0003567_abnormal_fetal_cardiomyocyte1.00934436
52MP0003315_abnormal_perineum_morphology1.00225411
53MP0000428_abnormal_craniofacial_morphol0.99879858
54MP0000358_abnormal_cell_content/0.98246561
55MP0003950_abnormal_plasma_membrane0.97929560
56MP0002233_abnormal_nose_morphology0.96068363
57MP0002210_abnormal_sex_determination0.95573953
58MP0009703_decreased_birth_body0.93126273
59MP0003385_abnormal_body_wall0.92846525
60MP0001346_abnormal_lacrimal_gland0.92324198
61MP0001929_abnormal_gametogenesis0.90352952
62MP0004233_abnormal_muscle_weight0.90223273
63MP0006035_abnormal_mitochondrial_morpho0.87098883
64MP0000762_abnormal_tongue_morphology0.87054939
65MP0000490_abnormal_crypts_of0.84658413
66MP0003755_abnormal_palate_morphology0.84612220
67MP0001661_extended_life_span0.83676528
68MP0003566_abnormal_cell_adhesion0.83408259
69MP0001145_abnormal_male_reproductive0.82719369
70MP0002019_abnormal_tumor_incidence0.82506587
71MP0001299_abnormal_eye_distance/0.81957806
72MP0003935_abnormal_craniofacial_develop0.81516559
73MP0000432_abnormal_head_morphology0.81390613
74MP0003119_abnormal_digestive_system0.80747248
75MP0003136_yellow_coat_color0.79662700
76MP0002234_abnormal_pharynx_morphology0.79465382
77MP0003861_abnormal_nervous_system0.76384816
78MP0005501_abnormal_skin_physiology0.74710186
79MP0005384_cellular_phenotype0.74023898
80MP0000647_abnormal_sebaceous_gland0.73918129
81MP0004272_abnormal_basement_membrane0.73346236
82MP0000653_abnormal_sex_gland0.72779787
83MP0000579_abnormal_nail_morphology0.72701479
84MP0002160_abnormal_reproductive_system0.72056275
85MP0003123_paternal_imprinting0.71798792
86MP0005621_abnormal_cell_physiology0.71154033
87MP0003942_abnormal_urinary_system0.68548853
88MP0005187_abnormal_penis_morphology0.68500613
89MP0003943_abnormal_hepatobiliary_system0.68367529
90MP0009250_abnormal_appendicular_skeleto0.67022422
91MP0003221_abnormal_cardiomyocyte_apopto0.66868137
92MP0005408_hypopigmentation0.65343032
93MP0005391_vision/eye_phenotype0.63712804
94MP0001727_abnormal_embryo_implantation0.63343041
95MP0000049_abnormal_middle_ear0.63215684
96MP0004808_abnormal_hematopoietic_stem0.61997444
97MP0002114_abnormal_axial_skeleton0.61055137
98MP0008877_abnormal_DNA_methylation0.60371692
99MP0002796_impaired_skin_barrier0.59245286
100MP0001119_abnormal_female_reproductive0.58120961

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.88961538
2Chromsome breakage (HP:0040012)5.53765987
3Abnormality of chromosome stability (HP:0003220)3.99060419
4Increased nuchal translucency (HP:0010880)3.92407811
5Meckel diverticulum (HP:0002245)3.83849536
6Cortical dysplasia (HP:0002539)3.71409844
7Aplasia/Hypoplasia of the uvula (HP:0010293)3.70618634
8Abnormality of the preputium (HP:0100587)3.69719818
9Volvulus (HP:0002580)3.66946909
10Abnormality of the ileum (HP:0001549)3.62198485
11Abnormal lung lobation (HP:0002101)3.61641697
12Nephroblastoma (Wilms tumor) (HP:0002667)3.60690972
13Embryonal renal neoplasm (HP:0011794)3.54329086
14Duodenal stenosis (HP:0100867)3.52596468
15Small intestinal stenosis (HP:0012848)3.52596468
16Birth length less than 3rd percentile (HP:0003561)3.06054857
17Aplasia/Hypoplasia of the sacrum (HP:0008517)2.97805740
18Abnormality of the duodenum (HP:0002246)2.94516360
19Myelodysplasia (HP:0002863)2.89112517
20Proximal placement of thumb (HP:0009623)2.68888174
21Abnormality of the carotid arteries (HP:0005344)2.66334080
22Deviation of the thumb (HP:0009603)2.64878894
23Abnormality of the fetal cardiovascular system (HP:0010948)2.63670588
24Abnormal umbilical cord blood vessels (HP:0011403)2.63670588
25Single umbilical artery (HP:0001195)2.63670588
26Sloping forehead (HP:0000340)2.63235387
27Absent radius (HP:0003974)2.58053329
28Reticulocytopenia (HP:0001896)2.56393676
29Abnormality of the umbilical cord (HP:0010881)2.50985190
30Ectopic kidney (HP:0000086)2.47801666
31Rhabdomyosarcoma (HP:0002859)2.41474555
32Missing ribs (HP:0000921)2.40461039
33Absent forearm bone (HP:0003953)2.38805597
34Aplasia involving forearm bones (HP:0009822)2.38805597
35Cafe-au-lait spot (HP:0000957)2.37029870
36Triphalangeal thumb (HP:0001199)2.24105180
37Deep philtrum (HP:0002002)2.23178173
38Selective tooth agenesis (HP:0001592)2.19838634
39Neoplasm of the colon (HP:0100273)2.19659501
40Choanal atresia (HP:0000453)2.17839342
41Clubbing of toes (HP:0100760)2.14330589
42Embryonal neoplasm (HP:0002898)2.09983454
43Multiple enchondromatosis (HP:0005701)2.04474821
44Abnormal auditory evoked potentials (HP:0006958)2.00420413
45Arteriovenous malformation (HP:0100026)1.95786415
46Progressive external ophthalmoplegia (HP:0000590)1.94970499
47Short middle phalanx of the 5th finger (HP:0004220)1.94402560
48Medulloblastoma (HP:0002885)1.93704905
49Abnormalities of placenta or umbilical cord (HP:0001194)1.92554131
50Microvesicular hepatic steatosis (HP:0001414)1.90715544
51Abnormality of glycolysis (HP:0004366)1.89702386
52High anterior hairline (HP:0009890)1.88298969
53Glioma (HP:0009733)1.88284295
54Ependymoma (HP:0002888)1.88211027
55Overlapping toe (HP:0001845)1.87589341
56Horseshoe kidney (HP:0000085)1.87185453
57Facial cleft (HP:0002006)1.86634517
58Abnormality of chromosome segregation (HP:0002916)1.85595255
59Colon cancer (HP:0003003)1.85312054
60Aplasia/Hypoplasia of the sternum (HP:0006714)1.83488243
61Abnormal number of incisors (HP:0011064)1.82929234
62Short thumb (HP:0009778)1.82259962
63Hypoplastic pelvis (HP:0008839)1.81468862
64Increased serum pyruvate (HP:0003542)1.78116842
65Duplication of thumb phalanx (HP:0009942)1.77623621
6611 pairs of ribs (HP:0000878)1.77582846
67Breast hypoplasia (HP:0003187)1.77139864
68Atresia of the external auditory canal (HP:0000413)1.76411588
69Abnormality of methionine metabolism (HP:0010901)1.75047625
70Progressive muscle weakness (HP:0003323)1.72040613
71Abnormality of the calcaneus (HP:0008364)1.69546041
72Astrocytoma (HP:0009592)1.67456819
73Abnormality of the astrocytes (HP:0100707)1.67456819
74Squamous cell carcinoma (HP:0002860)1.63789330
75Absent thumb (HP:0009777)1.62493136
76Ovarian neoplasm (HP:0100615)1.61010109
77Bifid tongue (HP:0010297)1.60213495
78Hypoplasia of the capital femoral epiphysis (HP:0003090)1.55413742
79Leiomyosarcoma (HP:0100243)1.53445655
80Uterine leiomyosarcoma (HP:0002891)1.53445655
81Spastic diplegia (HP:0001264)1.53387593
82Microglossia (HP:0000171)1.53042084
83Gastrointestinal carcinoma (HP:0002672)1.52968564
84Malignant gastrointestinal tract tumors (HP:0006749)1.52968564
85Abnormality of the labia minora (HP:0012880)1.51926634
86Abnormality of cochlea (HP:0000375)1.51468582
87Duplicated collecting system (HP:0000081)1.51429435
88Uterine neoplasm (HP:0010784)1.48603177
89Neoplasm of striated muscle (HP:0009728)1.48110903
90Spinal cord lesions (HP:0100561)1.48106171
91Syringomyelia (HP:0003396)1.48106171
92Pancreatic islet-cell hyperplasia (HP:0004510)1.47873508
93Aplasia/hypoplasia of the humerus (HP:0006507)1.47146490
94Bone marrow hypocellularity (HP:0005528)1.47008594
95Macrocytic anemia (HP:0001972)1.46444495
96Abnormal foot bone ossification (HP:0010675)1.46032056
97Tracheoesophageal fistula (HP:0002575)1.44876661
98Intestinal polyposis (HP:0200008)1.44595121
99Cutaneous melanoma (HP:0012056)1.43052638
100Neoplasm of the pancreas (HP:0002894)1.42877437

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.89718340
2TTK4.03164363
3NEK13.75871642
4WEE13.66632996
5CDC73.49292307
6PBK3.39350123
7SRPK12.80592119
8BRSK22.72983625
9PLK42.66203484
10TSSK62.64571390
11PLK32.46847898
12NEK22.31866397
13EIF2AK12.14225466
14PLK12.01680858
15MKNK21.96613753
16MKNK11.94313462
17BRSK11.87553396
18ZAK1.75645414
19CHEK21.67489811
20MST1R1.66913605
21TAF11.64207761
22EIF2AK31.63171362
23AURKB1.61214106
24VRK21.49201680
25PNCK1.41553940
26CCNB11.40516863
27MST41.36374769
28SCYL21.32510365
29ATR1.28704878
30LATS11.22294301
31TRIM281.16601772
32EIF2AK21.13042780
33CDK71.12991799
34VRK11.12322153
35NME21.11830363
36STK31.11014734
37BRAF1.08315354
38CHEK11.05588719
39LATS21.03580065
40STK101.00353312
41MAP3K81.00132015
42MET0.99106267
43AURKA0.97125898
44MAP3K100.97090291
45ERBB40.95135037
46STK40.89557529
47BRD40.88361509
48MELK0.87686413
49ERBB30.87087762
50PAK40.83613285
51ATM0.81604871
52PDK20.76030760
53CDK120.75928174
54SMG10.74298014
55STK160.73997921
56CDK10.69586577
57CDK80.67278113
58CDK60.66531962
59CDK40.66173596
60RPS6KA40.62259123
61RPS6KB20.62152146
62ALK0.62035969
63CLK10.61274908
64NUAK10.60963232
65STK38L0.60729628
66PASK0.58604457
67CDK20.55062957
68PLK20.50981277
69FGFR10.48053855
70EPHA20.46925919
71EEF2K0.45933208
72NME10.43060758
73BCR0.42912097
74DYRK30.42465126
75BMPR1B0.42024120
76CDK180.39320618
77CSNK2A20.38534561
78CSNK2A10.38528769
79CDK150.35683257
80TNIK0.34698870
81CDK30.34444232
82AKT20.33799230
83CSNK1E0.33141566
84PRKDC0.33023366
85PAK10.32615868
86CDK11A0.32530414
87CDK140.31784144
88NEK90.31484122
89MARK30.30843993
90STK390.29935499
91ICK0.29335663
92PRKCI0.29039373
93YES10.26832802
94PDGFRA0.25484575
95PAK20.24693478
96TGFBR10.23711654
97ACVR1B0.21262755
98PTK20.18866609
99CDK90.18532816
100DMPK0.17978604

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.62112536
2Mismatch repair_Homo sapiens_hsa034304.12626510
3Cell cycle_Homo sapiens_hsa041103.48885602
4Non-homologous end-joining_Homo sapiens_hsa034503.46254636
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.12695930
6Homologous recombination_Homo sapiens_hsa034403.00632634
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.93048572
8Proteasome_Homo sapiens_hsa030502.72347124
9RNA transport_Homo sapiens_hsa030132.71685240
10Fanconi anemia pathway_Homo sapiens_hsa034602.68895756
11Nucleotide excision repair_Homo sapiens_hsa034202.66628370
12Spliceosome_Homo sapiens_hsa030402.57147097
13Base excision repair_Homo sapiens_hsa034102.52234131
14One carbon pool by folate_Homo sapiens_hsa006702.25480818
15Ribosome_Homo sapiens_hsa030101.80383246
16RNA polymerase_Homo sapiens_hsa030201.76002443
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.74639632
18Pyrimidine metabolism_Homo sapiens_hsa002401.73941198
19Basal transcription factors_Homo sapiens_hsa030221.70121108
20mRNA surveillance pathway_Homo sapiens_hsa030151.66544428
21RNA degradation_Homo sapiens_hsa030181.66352308
22Oocyte meiosis_Homo sapiens_hsa041141.59329076
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.56280862
24p53 signaling pathway_Homo sapiens_hsa041151.55948964
25Biosynthesis of amino acids_Homo sapiens_hsa012301.51407807
26Pyruvate metabolism_Homo sapiens_hsa006201.37251651
27Protein export_Homo sapiens_hsa030601.26413743
28Vitamin B6 metabolism_Homo sapiens_hsa007501.21423299
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.20906441
30Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.19671031
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.17446695
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.16570960
33Selenocompound metabolism_Homo sapiens_hsa004501.15723364
34Purine metabolism_Homo sapiens_hsa002301.10379671
35Folate biosynthesis_Homo sapiens_hsa007901.05337924
36Carbon metabolism_Homo sapiens_hsa012001.03451079
37Thyroid cancer_Homo sapiens_hsa052160.98614021
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97671164
39Hippo signaling pathway_Homo sapiens_hsa043900.93089109
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.92382656
41Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85341622
42Adherens junction_Homo sapiens_hsa045200.84763970
43MicroRNAs in cancer_Homo sapiens_hsa052060.84551338
44Systemic lupus erythematosus_Homo sapiens_hsa053220.78559396
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78408101
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77998846
47Basal cell carcinoma_Homo sapiens_hsa052170.77305388
48TGF-beta signaling pathway_Homo sapiens_hsa043500.76635634
49Viral carcinogenesis_Homo sapiens_hsa052030.76265410
50Small cell lung cancer_Homo sapiens_hsa052220.74052457
51Alcoholism_Homo sapiens_hsa050340.73562412
52Propanoate metabolism_Homo sapiens_hsa006400.73521358
53Pentose phosphate pathway_Homo sapiens_hsa000300.72936990
54Steroid biosynthesis_Homo sapiens_hsa001000.72729558
55N-Glycan biosynthesis_Homo sapiens_hsa005100.71607835
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70182003
57Hedgehog signaling pathway_Homo sapiens_hsa043400.65780843
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65780824
59Sulfur relay system_Homo sapiens_hsa041220.60916128
60Huntingtons disease_Homo sapiens_hsa050160.60721773
61Lysine degradation_Homo sapiens_hsa003100.60268305
62Central carbon metabolism in cancer_Homo sapiens_hsa052300.58406200
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57807994
64Fatty acid elongation_Homo sapiens_hsa000620.56444850
65Wnt signaling pathway_Homo sapiens_hsa043100.55543966
66Glutathione metabolism_Homo sapiens_hsa004800.55250059
67Epstein-Barr virus infection_Homo sapiens_hsa051690.51648942
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48731174
69Colorectal cancer_Homo sapiens_hsa052100.48341803
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47769523
71Parkinsons disease_Homo sapiens_hsa050120.47553425
72Bladder cancer_Homo sapiens_hsa052190.44470813
73HTLV-I infection_Homo sapiens_hsa051660.44275063
74Prostate cancer_Homo sapiens_hsa052150.41837669
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41718775
76Chronic myeloid leukemia_Homo sapiens_hsa052200.35426219
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.34933425
78Proteoglycans in cancer_Homo sapiens_hsa052050.33017500
79Melanoma_Homo sapiens_hsa052180.32735212
80Metabolic pathways_Homo sapiens_hsa011000.31210264
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30740934
82Tight junction_Homo sapiens_hsa045300.30004735
83Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.29995302
84Pancreatic cancer_Homo sapiens_hsa052120.29867166
85Pathways in cancer_Homo sapiens_hsa052000.26781385
86Oxidative phosphorylation_Homo sapiens_hsa001900.26150507
87Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.25810641
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.24805496
89Fatty acid metabolism_Homo sapiens_hsa012120.24503652
90Sulfur metabolism_Homo sapiens_hsa009200.22223766
91Fatty acid biosynthesis_Homo sapiens_hsa000610.21273858
92Arginine and proline metabolism_Homo sapiens_hsa003300.19707246
93Galactose metabolism_Homo sapiens_hsa000520.19458498
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.19289632
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.17096004
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.16788519
97Arginine biosynthesis_Homo sapiens_hsa002200.15329702
98Alzheimers disease_Homo sapiens_hsa050100.13046966
99Apoptosis_Homo sapiens_hsa042100.11175986
100Non-small cell lung cancer_Homo sapiens_hsa052230.10922764

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