DEPTOR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-myosin filament sliding (GO:0033275)9.75328520
2muscle filament sliding (GO:0030049)9.75328520
3regulation of skeletal muscle contraction (GO:0014819)8.27782059
4skeletal muscle contraction (GO:0003009)8.17679116
5actin-mediated cell contraction (GO:0070252)7.98545748
6sarcoplasmic reticulum calcium ion transport (GO:0070296)7.97121121
7L-phenylalanine catabolic process (GO:0006559)6.84982887
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.84982887
9L-phenylalanine metabolic process (GO:0006558)6.58343976
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.58343976
11creatine metabolic process (GO:0006600)6.23354645
12regulation of relaxation of muscle (GO:1901077)6.22466516
13aromatic amino acid family catabolic process (GO:0009074)5.94237480
14response to stimulus involved in regulation of muscle adaptation (GO:0014874)5.92022342
15actin filament-based movement (GO:0030048)5.81889701
16positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.59899408
17striated muscle contraction (GO:0006941)5.55540959
18myofibril assembly (GO:0030239)5.51839155
19response to muscle activity (GO:0014850)5.45105046
20alpha-linolenic acid metabolic process (GO:0036109)5.31993592
21sulfur amino acid catabolic process (GO:0000098)5.19789917
22indole-containing compound catabolic process (GO:0042436)5.17775965
23indolalkylamine catabolic process (GO:0046218)5.17775965
24tryptophan catabolic process (GO:0006569)5.17775965
25triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.10891559
26bile acid biosynthetic process (GO:0006699)5.03576442
27cysteine metabolic process (GO:0006534)5.00594249
28tryptophan metabolic process (GO:0006568)4.95685277
29purine nucleotide salvage (GO:0032261)4.91963539
30urea cycle (GO:0000050)4.90642610
31urea metabolic process (GO:0019627)4.90642610
32glycogen catabolic process (GO:0005980)4.89871993
33fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.88956770
34skeletal muscle adaptation (GO:0043501)4.88673829
35kynurenine metabolic process (GO:0070189)4.88569708
36skeletal muscle fiber development (GO:0048741)4.70236818
37complement activation, alternative pathway (GO:0006957)4.68951754
38regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.63239204
39glyoxylate metabolic process (GO:0046487)4.59707808
40protein carboxylation (GO:0018214)4.59672693
41peptidyl-glutamic acid carboxylation (GO:0017187)4.59672693
42sarcomere organization (GO:0045214)4.59081938
43glucan catabolic process (GO:0009251)4.57718082
44nitrogen cycle metabolic process (GO:0071941)4.54853013
45response to inactivity (GO:0014854)4.54460587
46homocysteine metabolic process (GO:0050667)4.52766324
47NADH metabolic process (GO:0006734)4.51086997
48regulation of triglyceride catabolic process (GO:0010896)4.50573199
49acylglycerol homeostasis (GO:0055090)4.48827706
50triglyceride homeostasis (GO:0070328)4.48827706
51serine family amino acid catabolic process (GO:0009071)4.47702166
52myotube cell development (GO:0014904)4.46630769
53bile acid metabolic process (GO:0008206)4.46395534
54amino-acid betaine metabolic process (GO:0006577)4.42474743
55regulation of protein activation cascade (GO:2000257)4.41339941
56glucan biosynthetic process (GO:0009250)4.41179238
57glycogen biosynthetic process (GO:0005978)4.41179238
58muscle contraction (GO:0006936)4.39883572
59lysine metabolic process (GO:0006553)4.35575527
60lysine catabolic process (GO:0006554)4.35575527
61aromatic amino acid family metabolic process (GO:0009072)4.35233314
62high-density lipoprotein particle remodeling (GO:0034375)4.33677903
63cellular polysaccharide catabolic process (GO:0044247)4.32362004
64regulation of fibrinolysis (GO:0051917)4.24435591
65tyrosine metabolic process (GO:0006570)4.23649493
66negative regulation of fibrinolysis (GO:0051918)4.22599665
67coenzyme catabolic process (GO:0009109)4.18123378
68regulation of complement activation (GO:0030449)4.16767700
69fatty acid beta-oxidation (GO:0006635)4.15288003
70alpha-amino acid catabolic process (GO:1901606)4.12203425
71valine metabolic process (GO:0006573)4.09531588
72muscle system process (GO:0003012)4.05377316
73fatty acid oxidation (GO:0019395)4.01700603
74bile acid and bile salt transport (GO:0015721)3.99513044
75intestinal cholesterol absorption (GO:0030299)3.97983101
76fatty acid catabolic process (GO:0009062)3.94934172
77lipid oxidation (GO:0034440)3.93640209
78cellular amino acid catabolic process (GO:0009063)3.93448607
79cardiac myofibril assembly (GO:0055003)3.91321370
80short-chain fatty acid metabolic process (GO:0046459)3.91101887
81polysaccharide catabolic process (GO:0000272)3.90989969
82galactose catabolic process (GO:0019388)3.89963373
83reverse cholesterol transport (GO:0043691)3.87081293
84skeletal muscle tissue development (GO:0007519)3.86831967
85biotin metabolic process (GO:0006768)3.86526625
86regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.85033664
87cardiac muscle contraction (GO:0060048)3.84153446
88protein-lipid complex remodeling (GO:0034368)3.82670437
89macromolecular complex remodeling (GO:0034367)3.82670437
90plasma lipoprotein particle remodeling (GO:0034369)3.82670437
91cellular ketone body metabolic process (GO:0046950)3.77987093
92plasma lipoprotein particle clearance (GO:0034381)3.77304028
93monocarboxylic acid catabolic process (GO:0072329)3.76709760
94positive regulation of fatty acid beta-oxidation (GO:0032000)3.75687433
95indolalkylamine metabolic process (GO:0006586)3.75583931
96skeletal muscle tissue regeneration (GO:0043403)3.75511352
97acetyl-CoA metabolic process (GO:0006084)3.74320895
98organic acid catabolic process (GO:0016054)3.73072406
99carboxylic acid catabolic process (GO:0046395)3.73072406
100carnitine shuttle (GO:0006853)3.72619972
101phospholipid efflux (GO:0033700)3.72381237
102actomyosin structure organization (GO:0031032)3.72367530
103regulation of cholesterol esterification (GO:0010872)3.70475147
104striated muscle adaptation (GO:0014888)3.69093023
105branched-chain amino acid catabolic process (GO:0009083)3.68468514
106cellular modified amino acid catabolic process (GO:0042219)3.67250878
107positive regulation of lipid catabolic process (GO:0050996)3.65951519
108cellular biogenic amine catabolic process (GO:0042402)3.62093812
109amine catabolic process (GO:0009310)3.62093812
110plasma membrane repair (GO:0001778)3.60147104
111fatty acid transmembrane transport (GO:1902001)3.59995283
112muscle atrophy (GO:0014889)3.56552818
113cellular glucuronidation (GO:0052695)3.56347887
114regulation of cell communication by electrical coupling (GO:0010649)3.55859675
115regulation of cholesterol homeostasis (GO:2000188)3.54793819
116glycine metabolic process (GO:0006544)3.53644531
117ethanol oxidation (GO:0006069)3.52841556
118negative regulation of lipase activity (GO:0060192)3.52555978
119benzene-containing compound metabolic process (GO:0042537)3.51149452
120branched-chain amino acid metabolic process (GO:0009081)3.50655566
121relaxation of muscle (GO:0090075)3.50297552
122serine family amino acid metabolic process (GO:0009069)3.50063851
123negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.49375262
124cardiac muscle hypertrophy (GO:0003300)3.49295955
125carnitine metabolic process (GO:0009437)3.45561403
126imidazole-containing compound metabolic process (GO:0052803)3.44860299
127glycogen metabolic process (GO:0005977)3.44687805
128drug catabolic process (GO:0042737)3.43422239
129endothelium development (GO:0003158)3.41058980
130carnitine transport (GO:0015879)3.41029952
131amino-acid betaine transport (GO:0015838)3.41029952
132regulation of sequestering of triglyceride (GO:0010889)3.40742263
133ubiquinone biosynthetic process (GO:0006744)3.40530193
134regulation of bile acid biosynthetic process (GO:0070857)3.40404194
135phospholipid homeostasis (GO:0055091)3.39559132
136cytolysis (GO:0019835)3.39017668
137muscle fiber development (GO:0048747)3.38649402
138negative regulation of cholesterol transport (GO:0032375)3.38627596
139negative regulation of sterol transport (GO:0032372)3.38627596
140drug transmembrane transport (GO:0006855)3.38053089
141regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.37914713
142striated muscle hypertrophy (GO:0014897)3.37653642
143cholesterol efflux (GO:0033344)3.37031819
144cellular glucan metabolic process (GO:0006073)3.36925469
145glucan metabolic process (GO:0044042)3.36925469
146muscle cell cellular homeostasis (GO:0046716)3.35338721
147positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.35337449
148striated muscle atrophy (GO:0014891)3.34404398
149cofactor catabolic process (GO:0051187)3.34264777
150glutamate metabolic process (GO:0006536)3.33845761
151positive regulation of triglyceride lipase activity (GO:0061365)3.33622913
152positive regulation of lipoprotein lipase activity (GO:0051006)3.33622913
153drug metabolic process (GO:0017144)3.33532701
154tricarboxylic acid cycle (GO:0006099)3.33394178
155muscle organ morphogenesis (GO:0048644)3.33316105
156regulation of cholesterol metabolic process (GO:0090181)3.31685727
1572-oxoglutarate metabolic process (GO:0006103)3.31417119
158epoxygenase P450 pathway (GO:0019373)3.30144075
159cholesterol homeostasis (GO:0042632)3.28902688
160carnitine transmembrane transport (GO:1902603)3.28700204
161tricarboxylic acid metabolic process (GO:0072350)3.28674568
162fructose metabolic process (GO:0006000)3.28373940
163oxaloacetate metabolic process (GO:0006107)3.27908306
164nucleotide salvage (GO:0043173)3.27394448
165ketone body metabolic process (GO:1902224)3.25312296
166muscle hypertrophy (GO:0014896)3.25091246
167muscle adaptation (GO:0043500)3.21501041
168muscle cell fate commitment (GO:0042693)3.19832709
169IMP metabolic process (GO:0046040)3.18849759
170succinate metabolic process (GO:0006105)3.18849733
171gluconeogenesis (GO:0006094)3.17091971
172regulation of actin filament-based movement (GO:1903115)3.14000984
173positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.13962553
174response to mercury ion (GO:0046689)3.11935766
175negative regulation of calcium ion transmembrane transport (GO:1903170)3.11662388
176negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.11662388
177negative regulation of muscle contraction (GO:0045932)3.08178980
178positive regulation of vasculogenesis (GO:2001214)3.04957404
179galactose metabolic process (GO:0006012)3.03892305
180muscle organ development (GO:0007517)3.02440059
181negative regulation of necroptotic process (GO:0060546)3.00453232
182quinone biosynthetic process (GO:1901663)2.99679958
183muscle structure development (GO:0061061)2.99550073
184adenosine metabolic process (GO:0046085)2.98269060
185positive regulation of myotube differentiation (GO:0010831)2.91876482
186regulation of striated muscle contraction (GO:0006942)2.90865418
187cellular carbohydrate catabolic process (GO:0044275)2.90826862
188quaternary ammonium group transport (GO:0015697)2.90191871
189AMP metabolic process (GO:0046033)2.89355958
190hexose biosynthetic process (GO:0019319)2.86455014
191response to activity (GO:0014823)2.86041138
192ubiquinone metabolic process (GO:0006743)2.80059131
193regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.76736597

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.62101603
2RXR_22158963_ChIP-Seq_LIVER_Mouse7.56147410
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.42798618
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.10798995
5EGR1_23403033_ChIP-Seq_LIVER_Mouse6.05872152
6LXR_22158963_ChIP-Seq_LIVER_Mouse5.95015639
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.76290454
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.89713195
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.54791464
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.83683412
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.51366301
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.89933922
13BCL3_23251550_ChIP-Seq_MUSCLE_Mouse2.68620124
14CDX2_19796622_ChIP-Seq_MESCs_Mouse2.41829672
15RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.34258942
16GATA1_22025678_ChIP-Seq_K562_Human2.29303812
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.24956331
18TBX20_22328084_ChIP-Seq_HEART_Mouse2.08389292
19TBX20_22080862_ChIP-Seq_HEART_Mouse2.08389292
20* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.01361884
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.00663659
22ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.1410743
23SCL_19346495_ChIP-Seq_HPC-7_Human1.93217436
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.80303451
25TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.74665009
26CLOCK_20551151_ChIP-Seq_293T_Human1.70355358
27MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.64755485
28FOXA2_19822575_ChIP-Seq_HepG2_Human1.59062295
29LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.57964773
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.53340199
31EP300_21415370_ChIP-Seq_HL-1_Mouse1.47608675
32GATA4_21415370_ChIP-Seq_HL-1_Mouse1.45682794
33EZH2_22144423_ChIP-Seq_EOC_Human1.42776522
34HTT_18923047_ChIP-ChIP_STHdh_Human1.40910209
35STAT1_20625510_ChIP-Seq_HELA_Human1.38927784
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.34908148
37HNF4A_19822575_ChIP-Seq_HepG2_Human1.34328339
38SOX2_27498859_Chip-Seq_STOMACH_Mouse1.34098091
39CTCF_21964334_ChIP-Seq_BJAB-B_Human1.33781102
40ESR1_21235772_ChIP-Seq_MCF-7_Human1.29145033
41SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.27731017
42GATA1_19941827_ChIP-Seq_MEL_Mouse1.27401791
43NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.24995012
44IRF8_22096565_ChIP-ChIP_GC-B_Human1.23161635
45GATA4_25053715_ChIP-Seq_YYC3_Human1.18035047
46TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14963951
47ESR2_21235772_ChIP-Seq_MCF-7_Human1.09600648
48PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03728212
49GATA1_19941826_ChIP-Seq_K562_Human1.01999200
50TBX5_21415370_ChIP-Seq_HL-1_Mouse1.01202964
51ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00972481
52ESR1_20079471_ChIP-ChIP_T-47D_Human1.00649787
53AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.00218414
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00138335
55SPI1_20517297_ChIP-Seq_HL60_Human1.00138246
56FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.99565502
57CTCF_26484167_Chip-Seq_Bcells_Mouse0.98670573
58SMC3_22415368_ChIP-Seq_MEFs_Mouse0.98369185
59CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98356984
60IGF1R_20145208_ChIP-Seq_DFB_Human0.98006962
61SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95224985
62RXRA_24833708_ChIP-Seq_LIVER_Mouse0.94492927
63CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94236830
64Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.93292861
65ETS1_21867929_ChIP-Seq_TH2_Mouse0.92124180
66CTCF_21964334_Chip-Seq_Bcells_Human0.91814459
67BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90007076
68KAP1_22055183_ChIP-Seq_ESCs_Mouse0.89601950
69GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88698961
70OCT4_20526341_ChIP-Seq_ESCs_Human0.87890938
71NRF2_20460467_ChIP-Seq_MEFs_Mouse0.87596323
72NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.87596323
73RARG_19884340_ChIP-ChIP_MEFs_Mouse0.87499508
74P68_20966046_ChIP-Seq_HELA_Human0.87410258
75GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87171409
76TRIM28_21343339_ChIP-Seq_HEK293_Human0.87141818
77IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.86932254
78PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.86003622
79FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.85478249
80SOX2_20726797_ChIP-Seq_SW620_Human0.85060659
81LXR_22292898_ChIP-Seq_THP-1_Human0.83824433
82PPAR_26484153_Chip-Seq_NCI-H1993_Human0.83751862
83FOXA1_25552417_ChIP-Seq_VCAP_Human0.83566890
84PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.83199547
85PIAS1_25552417_ChIP-Seq_VCAP_Human0.81668048
86PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.81205633
87SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80929301
88ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.79460686
89PU.1_20513432_ChIP-Seq_Bcells_Mouse0.78595345
90ZNF263_19887448_ChIP-Seq_K562_Human0.78568694
91FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78484509
92ERG_20517297_ChIP-Seq_VCAP_Human0.78473701
93YY1_22570637_ChIP-Seq_MALME-3M_Human0.76466727
94AR_20517297_ChIP-Seq_VCAP_Human0.76105605
95SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.75968023
96SALL4_18804426_ChIP-ChIP_XEN_Mouse0.74932450
97SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74196209
98NFIB_24661679_ChIP-Seq_LUNG_Mouse0.74005783
99RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.72937603
100GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.72813349
101E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.72612730
102DNAJC2_21179169_ChIP-ChIP_NT2_Human0.72558632
103SA1_27219007_Chip-Seq_Bcells_Human0.72234335
104BCAT_22108803_ChIP-Seq_LS180_Human0.71937585
105PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.71873272
106SOX2_22085726_ChIP-Seq_NPCs_Mouse0.71845716
107VDR_21846776_ChIP-Seq_THP-1_Human0.71215620
108SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.71201206
109FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.70889148
110AUTS2_25519132_ChIP-Seq_293T-REX_Human0.70775242
111CTCF_27219007_Chip-Seq_Bcells_Human0.70582105
112RACK7_27058665_Chip-Seq_MCF-7_Human0.70315769
113CDX2_20551321_ChIP-Seq_CACO-2_Human0.69888431
114GATA3_24758297_ChIP-Seq_MCF-7_Human0.69786836
115GATA2_19941826_ChIP-Seq_K562_Human0.69630369
116ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.68996777
117AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.67234870
118ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.67032161
119GATA6_25053715_ChIP-Seq_YYC3_Human0.64992750
120TAF15_26573619_Chip-Seq_HEK293_Human0.64455462
121ESET_19884257_ChIP-Seq_ESCs_Mouse0.63908295
122GATA2_21666600_ChIP-Seq_HMVEC_Human0.63334336
123STAT1_17558387_ChIP-Seq_HELA_Human0.62801210
124CDX2_22108803_ChIP-Seq_LS180_Human0.62608248
125TP63_17297297_ChIP-ChIP_HaCaT_Human0.60591505
126ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.59652334
127CEBPB_22108803_ChIP-Seq_LS180_Human0.59305390
128CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.59072167
129RAD21_21589869_ChIP-Seq_MESCs_Mouse0.58510522
130CBP_21632823_ChIP-Seq_H3396_Human0.57875833
131IRF1_19129219_ChIP-ChIP_H3396_Human0.57154265
132RARA_24833708_ChIP-Seq_LIVER_Mouse0.57036916
133FOXO3_23340844_ChIP-Seq_DLD1_Human0.57017448
134ZNF217_24962896_ChIP-Seq_MCF-7_Human0.56704023
135BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.55520346
136TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.55108776
137NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.54853285
138TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.54719959
139EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.53990349
140PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.53350497
141THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.52403995
142CRX_20693478_ChIP-Seq_RETINA_Mouse0.52251303
143SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.51523005
144LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.50885930
145EZH2_27294783_Chip-Seq_NPCs_Mouse0.50077759
146OCT4_21477851_ChIP-Seq_ESCs_Mouse0.48054232
147SUZ12_27294783_Chip-Seq_NPCs_Mouse0.47661504
148PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.47422304
149FOXM1_26456572_ChIP-Seq_MCF-7_Human0.46270804
150NFE2_27457419_Chip-Seq_LIVER_Mouse0.45986300
151RARB_24833708_ChIP-Seq_LIVER_Mouse0.45945542
152TP63_23658742_ChIP-Seq_EP156T_Human0.45231456
153GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.44464838
154* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.44185682

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.41503738
2MP0004145_abnormal_muscle_electrophysio6.08318544
3MP0005360_urolithiasis6.08157604
4MP0005365_abnormal_bile_salt6.07526316
5MP0003646_muscle_fatigue5.89943713
6MP0005085_abnormal_gallbladder_physiolo5.72896387
7MP0000751_myopathy5.28251140
8MP0000749_muscle_degeneration4.79961024
9MP0008875_abnormal_xenobiotic_pharmacok4.29232292
10MP0004036_abnormal_muscle_relaxation3.97372788
11MP0003252_abnormal_bile_duct3.65165405
12MP0010329_abnormal_lipoprotein_level3.46469253
13MP0003806_abnormal_nucleotide_metabolis3.41150716
14MP0000747_muscle_weakness3.36369852
15MP0003195_calcinosis3.17433743
16MP0002106_abnormal_muscle_physiology3.09557756
17MP0000759_abnormal_skeletal_muscle3.05641274
18MP0005083_abnormal_biliary_tract3.00128696
19MP0002269_muscular_atrophy2.95667744
20MP0001666_abnormal_nutrient_absorption2.95486015
21MP0004087_abnormal_muscle_fiber2.94076456
22MP0005369_muscle_phenotype2.72694045
23MP0004084_abnormal_cardiac_muscle2.66400823
24MP0005332_abnormal_amino_acid2.62338223
25MP0005330_cardiomyopathy2.59313256
26MP0005670_abnormal_white_adipose2.56086781
27MP0004233_abnormal_muscle_weight2.48391286
28MP0000750_abnormal_muscle_regeneration2.40308456
29MP0002118_abnormal_lipid_homeostasis2.34092770
30MP0002332_abnormal_exercise_endurance2.34088010
31MP0003868_abnormal_feces_composition2.33579386
32MP0005620_abnormal_muscle_contractility2.29835934
33MP0009840_abnormal_foam_cell2.29191921
34MP0002108_abnormal_muscle_morphology2.13837658
35MP0000609_abnormal_liver_physiology2.11796277
36MP0003191_abnormal_cellular_cholesterol2.11343042
37MP0004019_abnormal_vitamin_homeostasis2.03896883
38MP0002138_abnormal_hepatobiliary_system1.78001034
39MP0005319_abnormal_enzyme/_coenzyme1.75593240
40MP0002396_abnormal_hematopoietic_system1.74809250
41MP0001764_abnormal_homeostasis1.66319062
42MP0000733_abnormal_muscle_development1.62117851
43MP0002876_abnormal_thyroid_physiology1.56154417
44MP0005220_abnormal_exocrine_pancreas1.55869358
45MP0004484_altered_response_of1.54712211
46MP0002972_abnormal_cardiac_muscle1.54528085
47MP0002971_abnormal_brown_adipose1.51768945
48MP0009643_abnormal_urine_homeostasis1.51364984
49MP0004130_abnormal_muscle_cell1.50427378
50MP0005666_abnormal_adipose_tissue1.49951815
51MP0004215_abnormal_myocardial_fiber1.43646878
52MP0005584_abnormal_enzyme/coenzyme_acti1.41496239
53MP0003186_abnormal_redox_activity1.40668654
54MP0010630_abnormal_cardiac_muscle1.40133796
55MP0005646_abnormal_pituitary_gland1.38591042
56MP0004147_increased_porphyrin_level1.37193317
57MP0002127_abnormal_cardiovascular_syste1.33657304
58MP0002078_abnormal_glucose_homeostasis1.32070056
59MP0005334_abnormal_fat_pad1.25555697
60MP0009697_abnormal_copulation1.24785082
61MP0005451_abnormal_body_composition1.23299015
62MP0006036_abnormal_mitochondrial_physio1.20433967
63MP0005535_abnormal_body_temperature1.18244204
64MP0008995_early_reproductive_senescence1.17105012
65MP0005084_abnormal_gallbladder_morpholo1.16874935
66MP0003724_increased_susceptibility_to1.15944263
67MP0005408_hypopigmentation1.12298606
68MP0002837_dystrophic_cardiac_calcinosis1.09115974
69MP0005647_abnormal_sex_gland1.08955691
70MP0005636_abnormal_mineral_homeostasis1.06591562
71MP0004043_abnormal_pH_regulation1.04460066
72MP0000598_abnormal_liver_morphology1.04037748
73MP0002254_reproductive_system_inflammat1.03837361
74MP0006138_congestive_heart_failure1.00725495
75MP0003011_delayed_dark_adaptation0.99835156
76MP0008004_abnormal_stomach_pH0.99829646
77MP0001544_abnormal_cardiovascular_syste0.99688856
78MP0005385_cardiovascular_system_phenoty0.99688856
79MP0005448_abnormal_energy_balance0.98089037
80MP0001756_abnormal_urination0.97788270
81MP0005375_adipose_tissue_phenotype0.97469869
82MP0001944_abnormal_pancreas_morphology0.96517774
83MP0001661_extended_life_span0.95895853
84MP0004264_abnormal_extraembryonic_tissu0.93365939
85MP0003183_abnormal_peptide_metabolism0.92295687
86MP0005379_endocrine/exocrine_gland_phen0.91638743
87MP0008775_abnormal_heart_ventricle0.90920794
88MP0003656_abnormal_erythrocyte_physiolo0.90770300
89MP0009642_abnormal_blood_homeostasis0.90030470
90MP0004185_abnormal_adipocyte_glucose0.89776828
91MP0003959_abnormal_lean_body0.87460058
92MP0002693_abnormal_pancreas_physiology0.86818258
93MP0000372_irregular_coat_pigmentation0.86760196
94MP0008438_abnormal_cutaneous_collagen0.85677123
95MP0009763_increased_sensitivity_to0.84279401
96MP0002970_abnormal_white_adipose0.81340503
97MP0005165_increased_susceptibility_to0.81142971
98MP0000681_abnormal_thyroid_gland0.80515595
99MP0009764_decreased_sensitivity_to0.79711121
100MP0003953_abnormal_hormone_level0.79377140
101MP0008469_abnormal_protein_level0.78907727
102MP0009115_abnormal_fat_cell0.78818932
103MP0001881_abnormal_mammary_gland0.76865565
104MP0009379_abnormal_foot_pigmentation0.76233990
105MP0004134_abnormal_chest_morphology0.76217213
106MP0004782_abnormal_surfactant_physiolog0.73343958
107MP0000013_abnormal_adipose_tissue0.72504323
108MP0009765_abnormal_xenobiotic_induced0.67858458
109MP0005275_abnormal_skin_tensile0.67336858
110MP0002928_abnormal_bile_duct0.65555894
111MP0009384_cardiac_valve_regurgitation0.65519693
112MP0004808_abnormal_hematopoietic_stem0.65408713
113MP0003705_abnormal_hypodermis_morpholog0.64337352
114MP0000579_abnormal_nail_morphology0.64187617
115MP0005376_homeostasis/metabolism_phenot0.64186733
116MP0000465_gastrointestinal_hemorrhage0.63132480
117MP0000639_abnormal_adrenal_gland0.62471672
118MP0005464_abnormal_platelet_physiology0.61811500
119MP0010368_abnormal_lymphatic_system0.61707222
120MP0002060_abnormal_skin_morphology0.59686435
121MP0000003_abnormal_adipose_tissue0.59151285
122MP0005395_other_phenotype0.58739213
123MP0003879_abnormal_hair_cell0.58401456
124MP0005266_abnormal_metabolism0.58236263
125MP0004085_abnormal_heartbeat0.56037469
126MP0005452_abnormal_adipose_tissue0.54742232
127MP0002128_abnormal_blood_circulation0.53709524
128MP0002168_other_aberrant_phenotype0.53564104
129MP0009780_abnormal_chondrocyte_physiolo0.53243507
130MP0004381_abnormal_hair_follicle0.53222877
131MP0005166_decreased_susceptibility_to0.52632170
132MP0000230_abnormal_systemic_arterial0.52523749
133MP0002909_abnormal_adrenal_gland0.52439007
134MP0000266_abnormal_heart_morphology0.51651902
135MP0001765_abnormal_ion_homeostasis0.51521723
136MP0003045_fibrosis0.50745880
137MP0002822_catalepsy0.49782191
138MP0005058_abnormal_lysosome_morphology0.49192050
139MP0004270_analgesia0.49059968
140MP0002877_abnormal_melanocyte_morpholog0.47741671
141MP0006035_abnormal_mitochondrial_morpho0.47128555
142MP0002796_impaired_skin_barrier0.46765804
143MP0003718_maternal_effect0.46571375
144MP0000427_abnormal_hair_cycle0.46486013
145MP0003300_gastrointestinal_ulcer0.46442320
146MP0005595_abnormal_vascular_smooth0.46424253
147MP0002136_abnormal_kidney_physiology0.46373528
148MP0000604_amyloidosis0.43664280
149MP0003828_pulmonary_edema0.43506937
150MP0003279_aneurysm0.43242344
151MP0000613_abnormal_salivary_gland0.39522381
152MP0001986_abnormal_taste_sensitivity0.39480058
153MP0005075_abnormal_melanosome_morpholog0.37973262
154MP0000538_abnormal_urinary_bladder0.37342432
155MP0005248_abnormal_Harderian_gland0.36551241

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)9.97114442
2Nemaline bodies (HP:0003798)9.95969586
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)9.63271149
4Exercise-induced myalgia (HP:0003738)8.02012451
5Type 1 muscle fiber predominance (HP:0003803)7.31061159
6Abnormality of aromatic amino acid family metabolism (HP:0004338)6.80607541
7Intrahepatic cholestasis (HP:0001406)6.37363563
8Exercise-induced muscle cramps (HP:0003710)6.36346350
9Distal arthrogryposis (HP:0005684)6.20057347
10Prolonged partial thromboplastin time (HP:0003645)5.85362072
11Myopathic facies (HP:0002058)5.81673640
12Abnormality of monocarboxylic acid metabolism (HP:0010996)5.63698237
13Deep venous thrombosis (HP:0002625)5.50356803
14Muscle hypertrophy of the lower extremities (HP:0008968)5.48380190
15Xanthomatosis (HP:0000991)5.34194141
16Hypoglycemic coma (HP:0001325)5.21351654
17Round ear (HP:0100830)5.11153511
18Rhabdomyolysis (HP:0003201)4.96891302
19Calf muscle hypertrophy (HP:0008981)4.78438229
20Hyperglycinuria (HP:0003108)4.77249290
21Hyperglycinemia (HP:0002154)4.71466156
22EMG: myopathic abnormalities (HP:0003458)4.70305472
23Hypobetalipoproteinemia (HP:0003563)4.69310324
24Complement deficiency (HP:0004431)4.59284799
25Ketosis (HP:0001946)4.55576671
26Ulnar deviation of the wrist (HP:0003049)4.49981256
27Muscle fiber splitting (HP:0003555)4.49912926
28Hyperlipoproteinemia (HP:0010980)4.43897092
29Hyporeflexia of lower limbs (HP:0002600)4.40151105
30Centrally nucleated skeletal muscle fibers (HP:0003687)4.33604243
31Abnormality of glycine metabolism (HP:0010895)4.31186562
32Abnormality of serine family amino acid metabolism (HP:0010894)4.31186562
33Hyperammonemia (HP:0001987)4.29946612
34Neck muscle weakness (HP:0000467)4.18117003
35Abnormality of the intrinsic pathway (HP:0010989)4.14393705
36Joint hemorrhage (HP:0005261)4.09655453
37Epidermoid cyst (HP:0200040)4.09591560
38Abnormality of the common coagulation pathway (HP:0010990)4.06862240
39Rimmed vacuoles (HP:0003805)3.96382322
40Ketoacidosis (HP:0001993)3.92542059
41Abnormality of glutamine family amino acid metabolism (HP:0010902)3.90799692
42Conjugated hyperbilirubinemia (HP:0002908)3.90514726
43Hypolipoproteinemia (HP:0010981)3.89884013
44Abnormality of skeletal muscle fiber size (HP:0012084)3.89245599
45Fat malabsorption (HP:0002630)3.86076949
46Abnormality of fatty-acid metabolism (HP:0004359)3.85239420
47Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.82197830
48Muscle stiffness (HP:0003552)3.75594260
49Hypoalphalipoproteinemia (HP:0003233)3.75276425
50Calcaneovalgus deformity (HP:0001848)3.66069009
51Abnormality of the calf musculature (HP:0001430)3.65450593
52Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.65101853
53Hypoglycemic seizures (HP:0002173)3.63512895
54Absent phalangeal crease (HP:0006109)3.56717020
55Abnormality of aspartate family amino acid metabolism (HP:0010899)3.52201871
56Abnormality of methionine metabolism (HP:0010901)3.51422653
57Abnormality of sulfur amino acid metabolism (HP:0004339)3.50362755
58Subaortic stenosis (HP:0001682)3.46063864
59Abnormality of the left ventricular outflow tract (HP:0011103)3.46063864
60Abnormality of complement system (HP:0005339)3.35227738
61Malignant hyperthermia (HP:0002047)3.34276492
62Deformed tarsal bones (HP:0008119)3.31267712
63Myotonia (HP:0002486)3.25325764
64Hyperinsulinemic hypoglycemia (HP:0000825)3.24602642
65Areflexia of lower limbs (HP:0002522)3.18619923
66Dicarboxylic aciduria (HP:0003215)3.18291538
67Abnormality of dicarboxylic acid metabolism (HP:0010995)3.18291538
68Increased variability in muscle fiber diameter (HP:0003557)3.15380120
69Asymmetric septal hypertrophy (HP:0001670)3.11778935
70Generalized aminoaciduria (HP:0002909)3.07001947
71Abnormality of serum amino acid levels (HP:0003112)3.06950014
72Hyperglycemia (HP:0003074)3.06110685
73Distal lower limb muscle weakness (HP:0009053)3.02624093
74Hypercholesterolemia (HP:0003124)3.00803330
75Difficulty running (HP:0009046)2.97805578
76Abnormal finger flexion creases (HP:0006143)2.97146901
77Hyperbilirubinemia (HP:0002904)2.96674811
78Abnormality of purine metabolism (HP:0004352)2.94891820
79Abnormality of nucleobase metabolism (HP:0010932)2.92740490
80Increased connective tissue (HP:0009025)2.91992810
81Late onset (HP:0003584)2.90295993
82Abnormality of pyrimidine metabolism (HP:0004353)2.88437831
83Steatorrhea (HP:0002570)2.85694139
84Symptomatic seizures (HP:0011145)2.84155896
85Metabolic acidosis (HP:0001942)2.82118031
86Lethargy (HP:0001254)2.80193584
87Myocardial infarction (HP:0001658)2.80144565
88Bulbar palsy (HP:0001283)2.78399547
89Pancreatitis (HP:0001733)2.78306077
90Progressive muscle weakness (HP:0003323)2.75911705
91Gout (HP:0001997)2.75104895
92EMG: neuropathic changes (HP:0003445)2.74017150
93Skin nodule (HP:0200036)2.73758740
94Generalized muscle weakness (HP:0003324)2.72002625
95Sudden death (HP:0001699)2.69541782
96Fetal akinesia sequence (HP:0001989)2.69430172
97Hyperkalemia (HP:0002153)2.69335840
98Frequent falls (HP:0002359)2.64318730
99Delayed CNS myelination (HP:0002188)2.62509934
100Weak cry (HP:0001612)2.59633756
101Renal cortical cysts (HP:0000803)2.58669532
102Bundle branch block (HP:0011710)2.58270749
103Proximal tubulopathy (HP:0000114)2.43231527
104Cerebral edema (HP:0002181)2.36706048
105Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.34112563
106Abnormality of alanine metabolism (HP:0010916)2.34112563
107Hyperalaninemia (HP:0003348)2.34112563
108Hydroxyprolinuria (HP:0003080)2.33899139
109Abnormality of proline metabolism (HP:0010907)2.33899139
110Dilated cardiomyopathy (HP:0001644)2.29792480
111Insulin-resistant diabetes mellitus (HP:0000831)2.29293059
112Gowers sign (HP:0003391)2.29007719
113Irritability (HP:0000737)2.28525657
114Hepatocellular carcinoma (HP:0001402)2.28421247
115Mildly elevated creatine phosphokinase (HP:0008180)2.22817767
116Fatigable weakness (HP:0003473)2.18177346
117Abnormality of the neuromuscular junction (HP:0003398)2.18177346
118Systemic lupus erythematosus (HP:0002725)2.17026064
119Long clavicles (HP:0000890)2.14932343
120Insulin resistance (HP:0000855)2.12600468
121Vomiting (HP:0002013)2.11828292
122Menorrhagia (HP:0000132)2.11343551
123Brushfield spots (HP:0001088)2.10681612
124Abnormality of urine glucose concentration (HP:0011016)2.10543080
125Glycosuria (HP:0003076)2.10543080
126Hypochromic microcytic anemia (HP:0004840)2.10285967
127Type 2 muscle fiber atrophy (HP:0003554)2.07012516
128Oligomenorrhea (HP:0000876)2.06772351
129Ragged-red muscle fibers (HP:0003200)2.02826891
130Abnormal gallbladder morphology (HP:0012437)2.02483860
131Enlarged kidneys (HP:0000105)2.01664374
132Facial diplegia (HP:0001349)2.01647286
133Reduced antithrombin III activity (HP:0001976)2.00861045
134Increased intramyocellular lipid droplets (HP:0012240)1.99576721
135Spontaneous abortion (HP:0005268)1.99296099
136Vascular calcification (HP:0004934)1.99234088
137Glomerulonephritis (HP:0000099)1.99072330
138Ventricular tachycardia (HP:0004756)1.97544709
139Hemorrhage of the eye (HP:0011885)1.96490953
140Hypertriglyceridemia (HP:0002155)1.96475192
141Malnutrition (HP:0004395)1.96129974
142Exercise intolerance (HP:0003546)1.95905158
143Scapular winging (HP:0003691)1.95628237
144Acanthocytosis (HP:0001927)1.95481055
145Spinal rigidity (HP:0003306)1.95194791
146Neonatal onset (HP:0003623)1.94799539
147Hip contracture (HP:0003273)1.94046873
148Increased purine levels (HP:0004368)1.93522636
149Hyperuricemia (HP:0002149)1.93522636
150Muscle fiber atrophy (HP:0100295)1.93160195
151Increased muscle lipid content (HP:0009058)1.92809397
152Alkalosis (HP:0001948)1.92739500
153Myoglobinuria (HP:0002913)1.90542937
154Elevated hepatic transaminases (HP:0002910)1.90244150
155Slender build (HP:0001533)1.89706440
156Sensorimotor neuropathy (HP:0007141)1.88923161
157Waddling gait (HP:0002515)1.88828416
158Opisthotonus (HP:0002179)1.88335045
159Abnormality of the calcaneus (HP:0008364)1.86174480
160Cerebral palsy (HP:0100021)1.83205232
161Abnormality of transition element cation homeostasis (HP:0011030)1.83201083
162Nausea (HP:0002018)1.82624671
163Heart block (HP:0012722)1.82542844
164Abnormality of vitamin metabolism (HP:0100508)1.82181425
165Amyloidosis (HP:0011034)1.81693433
166Distal lower limb amyotrophy (HP:0008944)1.81361593
167Acute hepatic failure (HP:0006554)1.80684738
168Cholelithiasis (HP:0001081)1.80042380
169Popliteal pterygium (HP:0009756)1.78880975
170Esophageal varix (HP:0002040)1.78150098
171Abnormal cartilage morphology (HP:0002763)1.77376031
172Hepatic necrosis (HP:0002605)1.76705047
173Muscular dystrophy (HP:0003560)1.76536844
174Fatigue (HP:0012378)1.74766705
175Lipoatrophy (HP:0100578)1.73450520
176Respiratory insufficiency due to muscle weakness (HP:0002747)1.72628970
177Abnormal atrioventricular conduction (HP:0005150)1.65989982
178Limb-girdle muscle atrophy (HP:0003797)1.64786618
179Paralysis (HP:0003470)1.61924840
180Metatarsus adductus (HP:0001840)1.60031978
181Nonprogressive disorder (HP:0003680)1.59204896
182Breech presentation (HP:0001623)1.55173369
183Proximal amyotrophy (HP:0007126)1.54841466
184Abnormality of the shoulder girdle musculature (HP:0001435)1.53685742
185Difficulty climbing stairs (HP:0003551)1.52312966
186Abnormality of potassium homeostasis (HP:0011042)1.52310884
187Hypokalemia (HP:0002900)1.44111193

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.04365225
2PHKG15.49722472
3PHKG25.49722472
4INSRR4.63668206
5TTN4.22096718
6SIK13.92697485
7TAOK33.85989074
8FRK3.54043206
9ERN13.30148515
10PIK3CG2.68464055
11FGFR42.61515064
12MST1R2.27183204
13IRAK32.20233832
14MAPK152.19220834
15LATS12.18576919
16CAMK1D2.12338803
17MAP3K22.10536781
18ERBB42.03244035
19SCYL21.87556885
20CCNB11.72727381
21MUSK1.64148036
22FLT31.63823406
23MAP3K31.58583028
24MAP4K21.52962153
25PRKAA21.52505860
26EPHA31.47374440
27MAPK111.41863081
28IRAK11.40195673
29PINK11.38402420
30STK38L1.36239046
31NLK1.33765564
32NEK91.33373236
33RPS6KB21.33003446
34KIT1.30031378
35PIK3CA1.29529230
36TRPM71.27533365
37KDR1.23565147
38MAP2K41.23075829
39TRIB31.22851918
40EEF2K1.21548252
41CAMK1G1.20092576
42JAK21.06600528
43NEK11.04853764
44PBK1.02635642
45MAP3K111.00154287
46ABL20.93730984
47HIPK20.93157841
48JAK10.91768329
49IRAK20.90342003
50PRKAA10.90185401
51MAPKAPK30.89489138
52MAP3K10.87663440
53MAP2K20.84238481
54MAP3K60.83361609
55AKT20.83293702
56WNK30.82251360
57FER0.79816301
58NUAK10.79497698
59FGFR30.78433765
60AKT30.75473358
61TYK20.73737280
62CAMKK20.73518343
63MAP2K10.72592158
64MET0.71892791
65CAMK2D0.70461319
66MAPK70.69064778
67NME10.67274508
68SGK20.66062977
69TNK20.65924395
70JAK30.65168628
71TGFBR20.65032641
72PTK60.64805193
73ERBB20.64440746
74CDK60.64321868
75IRAK40.62822904
76MAP3K70.62500499
77EPHB10.60027851
78TIE10.58307946
79WNK40.58304349
80PDK40.55514824
81PDK30.55514824
82EIF2AK30.54341463
83PRKG10.53615212
84GSK3A0.52500807
85MAP2K30.51880456
86CSF1R0.50645226
87PRKACG0.50322804
88MAPK40.50301900
89SGK30.50241003
90RET0.49395003
91CDK90.48789737
92FES0.47806492
93MAP3K140.47589511
94FGFR20.47249391
95IGF1R0.46731821
96DYRK1B0.46601162
97PRPF4B0.46268654
98IKBKE0.46097249
99MAP2K60.45929528
100CAMK2B0.45224896
101MOS0.45143534
102PRKG20.44503101
103MAP3K130.44053207
104PDK20.43380301
105GRK10.41698484
106PDPK10.39784133
107PTK20.39227337
108SGK2230.38905738
109SGK4940.38905738
110CAMK10.36543076
111RIPK10.36335873
112OBSCN0.36171774
113CSNK1G10.35672507
114PRKCZ0.33927115
115PRKACA0.33292828
116TBK10.32875035
117PIM20.31857135
118EPHA20.30572356
119CSK0.30235458
120PKN10.30063796
121SGK10.29737093
122CAMK40.29227924
123MAPK120.29111785
124* RPS6KB10.28924358
125CDK80.28214922
126VRK20.27744744
127LIMK10.27580015
128CAMK2G0.27297876
129RPS6KA30.26941254
130NME20.26281924
131MAPKAPK50.25897728
132PRKD10.25890350
133DMPK0.25462867
134TEC0.24395980
135NTRK10.24187406
136CHUK0.23823516
137ADRBK20.23594673
138EIF2AK20.23478988
139MAPK30.23344086
140ZAP700.23330703
141CAMK2A0.23179743
142DAPK20.22840479
143ERBB30.22333346
144PRKCQ0.20906619
145MAPK100.18079349
146PDK10.17776334
147PRKACB0.17582579
148PRKCA0.17241333
149SYK0.15038521
150MAP3K50.13592576

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.95995323
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.09564334
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.99954400
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.90747546
5Nitrogen metabolism_Homo sapiens_hsa009102.90063616
6Fatty acid degradation_Homo sapiens_hsa000712.79869296
7Dilated cardiomyopathy_Homo sapiens_hsa054142.67468242
8Tryptophan metabolism_Homo sapiens_hsa003802.66916985
9Propanoate metabolism_Homo sapiens_hsa006402.55370095
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.53155169
11Arginine biosynthesis_Homo sapiens_hsa002202.48885662
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.38954524
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.33654203
14Cardiac muscle contraction_Homo sapiens_hsa042602.31880137
15Complement and coagulation cascades_Homo sapiens_hsa046102.30377614
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.29754714
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.26567207
18Peroxisome_Homo sapiens_hsa041462.17545736
19PPAR signaling pathway_Homo sapiens_hsa033202.17531520
20Pentose and glucuronate interconversions_Homo sapiens_hsa000402.17441688
21Fatty acid metabolism_Homo sapiens_hsa012122.15183471
22Butanoate metabolism_Homo sapiens_hsa006502.13605761
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.99582483
24Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.89558815
25Sulfur metabolism_Homo sapiens_hsa009201.88873029
26beta-Alanine metabolism_Homo sapiens_hsa004101.85960262
27Caffeine metabolism_Homo sapiens_hsa002321.84553407
28Histidine metabolism_Homo sapiens_hsa003401.83861614
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.75729272
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.72832321
31Chemical carcinogenesis_Homo sapiens_hsa052041.70796542
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.67620655
33Folate biosynthesis_Homo sapiens_hsa007901.66501156
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.62805774
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.62319513
36Selenocompound metabolism_Homo sapiens_hsa004501.58660881
37Fat digestion and absorption_Homo sapiens_hsa049751.56494564
38Pyruvate metabolism_Homo sapiens_hsa006201.52905483
39Fatty acid elongation_Homo sapiens_hsa000621.51561490
40Starch and sucrose metabolism_Homo sapiens_hsa005001.50579245
41Retinol metabolism_Homo sapiens_hsa008301.50369111
42Phenylalanine metabolism_Homo sapiens_hsa003601.42444845
43Calcium signaling pathway_Homo sapiens_hsa040201.42401412
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.41357594
45Tyrosine metabolism_Homo sapiens_hsa003501.37768404
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.35591213
47ABC transporters_Homo sapiens_hsa020101.35462549
48Staphylococcus aureus infection_Homo sapiens_hsa051501.34871919
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.30681922
50Bile secretion_Homo sapiens_hsa049761.24969256
51Renin secretion_Homo sapiens_hsa049241.18864732
52Parkinsons disease_Homo sapiens_hsa050121.17367099
53Fatty acid biosynthesis_Homo sapiens_hsa000611.14403697
54Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.13923298
55Carbon metabolism_Homo sapiens_hsa012001.11794577
56Glycerolipid metabolism_Homo sapiens_hsa005611.09823616
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.08228844
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06340587
59Oxidative phosphorylation_Homo sapiens_hsa001901.03172979
60cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02502838
61Oxytocin signaling pathway_Homo sapiens_hsa049211.01250513
62Alzheimers disease_Homo sapiens_hsa050100.95892940
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.95695381
64Steroid biosynthesis_Homo sapiens_hsa001000.95680364
65Biosynthesis of amino acids_Homo sapiens_hsa012300.89992835
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89944774
67Vitamin digestion and absorption_Homo sapiens_hsa049770.87788228
68Sulfur relay system_Homo sapiens_hsa041220.85700677
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83209629
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.82404123
71Arginine and proline metabolism_Homo sapiens_hsa003300.82382873
72Vitamin B6 metabolism_Homo sapiens_hsa007500.80806346
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80428077
74Lysine degradation_Homo sapiens_hsa003100.79403261
75Protein export_Homo sapiens_hsa030600.73250866
76Platelet activation_Homo sapiens_hsa046110.73030066
77Cyanoamino acid metabolism_Homo sapiens_hsa004600.64643410
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62717295
79Salivary secretion_Homo sapiens_hsa049700.62484967
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62292153
81Pentose phosphate pathway_Homo sapiens_hsa000300.60466547
82Glutathione metabolism_Homo sapiens_hsa004800.59148527
83Gastric acid secretion_Homo sapiens_hsa049710.59013198
84Metabolic pathways_Homo sapiens_hsa011000.53963731
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52670153
86Galactose metabolism_Homo sapiens_hsa000520.52491640
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51096699
88Insulin resistance_Homo sapiens_hsa049310.49388558
89Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47644986
90Linoleic acid metabolism_Homo sapiens_hsa005910.46100797
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.45599226
92Fructose and mannose metabolism_Homo sapiens_hsa000510.44976690
93Purine metabolism_Homo sapiens_hsa002300.42546570
94One carbon pool by folate_Homo sapiens_hsa006700.38908263
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38056586
96Base excision repair_Homo sapiens_hsa034100.37270756
97AMPK signaling pathway_Homo sapiens_hsa041520.36019987
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.35713364
99Glucagon signaling pathway_Homo sapiens_hsa049220.35004607
100Olfactory transduction_Homo sapiens_hsa047400.33541736
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32998213
102Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30734078
103Circadian entrainment_Homo sapiens_hsa047130.29416355
104Prion diseases_Homo sapiens_hsa050200.27806766
105Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.24975718
106Long-term potentiation_Homo sapiens_hsa047200.24095184
107Protein digestion and absorption_Homo sapiens_hsa049740.18887865
108Insulin signaling pathway_Homo sapiens_hsa049100.15762890
109Regulation of autophagy_Homo sapiens_hsa041400.15353956
110Arachidonic acid metabolism_Homo sapiens_hsa005900.12716302
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.12584727
112Ovarian steroidogenesis_Homo sapiens_hsa049130.11334611
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.11232456
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.10539248
115Circadian rhythm_Homo sapiens_hsa047100.09861716
116Other glycan degradation_Homo sapiens_hsa005110.08966081
117Pancreatic secretion_Homo sapiens_hsa049720.06916887
118Renin-angiotensin system_Homo sapiens_hsa046140.00420431
119Thyroid cancer_Homo sapiens_hsa05216-0.1029934
120Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0830634
121Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0650287
122N-Glycan biosynthesis_Homo sapiens_hsa00510-0.0524101
123Type II diabetes mellitus_Homo sapiens_hsa04930-0.0513692
124Lysosome_Homo sapiens_hsa04142-0.0500518
125Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0068247

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