DERA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine metabolic process (GO:0006558)5.17338563
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.17338563
3L-phenylalanine catabolic process (GO:0006559)5.10261352
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.10261352
5aromatic amino acid family catabolic process (GO:0009074)4.76384944
6protein neddylation (GO:0045116)4.75801187
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.47180243
8tryptophan catabolic process (GO:0006569)4.47130074
9indole-containing compound catabolic process (GO:0042436)4.47130074
10indolalkylamine catabolic process (GO:0046218)4.47130074
11glycine metabolic process (GO:0006544)4.46126708
12glyoxylate metabolic process (GO:0046487)4.30689034
13kynurenine metabolic process (GO:0070189)4.24115190
14tryptophan metabolic process (GO:0006568)4.23505484
15serine family amino acid biosynthetic process (GO:0009070)4.19977452
16cysteine metabolic process (GO:0006534)4.17991275
17urea metabolic process (GO:0019627)4.13823128
18urea cycle (GO:0000050)4.13823128
19bile acid biosynthetic process (GO:0006699)4.02136581
20sulfur amino acid catabolic process (GO:0000098)4.01495768
21proteasome assembly (GO:0043248)3.99419871
22serine family amino acid catabolic process (GO:0009071)3.96011173
23serine family amino acid metabolic process (GO:0009069)3.91621556
24nitrogen cycle metabolic process (GO:0071941)3.82573328
25respiratory chain complex IV assembly (GO:0008535)3.81576801
26alpha-linolenic acid metabolic process (GO:0036109)3.78206187
27aldehyde catabolic process (GO:0046185)3.75018688
28high-density lipoprotein particle remodeling (GO:0034375)3.73434365
29fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.69238268
30negative regulation of fibrinolysis (GO:0051918)3.68404202
31homocysteine metabolic process (GO:0050667)3.65131100
32aromatic amino acid family metabolic process (GO:0009072)3.58302905
33lysine metabolic process (GO:0006553)3.51790218
34lysine catabolic process (GO:0006554)3.51790218
35imidazole-containing compound metabolic process (GO:0052803)3.48106937
36amino-acid betaine metabolic process (GO:0006577)3.46362063
37regulation of fibrinolysis (GO:0051917)3.45055255
38peptidyl-glutamic acid carboxylation (GO:0017187)3.44103462
39protein carboxylation (GO:0018214)3.44103462
40bile acid metabolic process (GO:0008206)3.43030676
41regulation of protein activation cascade (GO:2000257)3.41284768
42regulation of triglyceride catabolic process (GO:0010896)3.39913683
43L-serine metabolic process (GO:0006563)3.38740763
44glutathione derivative metabolic process (GO:1901685)3.36485390
45glutathione derivative biosynthetic process (GO:1901687)3.36485390
46complement activation, alternative pathway (GO:0006957)3.35851701
47negative regulation of cholesterol transport (GO:0032375)3.34601085
48negative regulation of sterol transport (GO:0032372)3.34601085
49regulation of cholesterol esterification (GO:0010872)3.31126218
50protein-lipid complex remodeling (GO:0034368)3.28459119
51macromolecular complex remodeling (GO:0034367)3.28459119
52plasma lipoprotein particle remodeling (GO:0034369)3.28459119
53regulation of integrin-mediated signaling pathway (GO:2001044)3.28300241
54alpha-amino acid catabolic process (GO:1901606)3.28158209
55cellular glucuronidation (GO:0052695)3.26222774
56folic acid-containing compound biosynthetic process (GO:0009396)3.26216508
57response to nitrosative stress (GO:0051409)3.24882971
58tetrahydrofolate metabolic process (GO:0046653)3.23871719
59ethanol oxidation (GO:0006069)3.20823051
60reverse cholesterol transport (GO:0043691)3.20334525
61phospholipid efflux (GO:0033700)3.19237553
62regulation of complement activation (GO:0030449)3.17764955
63regulation of cellular amino acid metabolic process (GO:0006521)3.16236645
64deoxyribonucleotide biosynthetic process (GO:0009263)3.16152494
65amine catabolic process (GO:0009310)3.12194529
66cellular biogenic amine catabolic process (GO:0042402)3.12194529
67folic acid metabolic process (GO:0046655)3.12135120
68tyrosine metabolic process (GO:0006570)3.11351877
69pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.10387066
70indolalkylamine metabolic process (GO:0006586)3.09675839
71nucleoside salvage (GO:0043174)3.09566587
72deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.08766185
73bile acid and bile salt transport (GO:0015721)3.06585098
74acylglycerol homeostasis (GO:0055090)3.05068172
75triglyceride homeostasis (GO:0070328)3.05068172
76plasma lipoprotein particle clearance (GO:0034381)3.03579947
77cellular amino acid catabolic process (GO:0009063)3.02280177
78benzene-containing compound metabolic process (GO:0042537)3.01470330
79one-carbon metabolic process (GO:0006730)3.00864595
80positive regulation of triglyceride lipase activity (GO:0061365)3.00625593
81positive regulation of lipoprotein lipase activity (GO:0051006)3.00625593
82plasma lipoprotein particle assembly (GO:0034377)3.00437449
83regulation of metalloenzyme activity (GO:0048552)2.96731534
84tricarboxylic acid cycle (GO:0006099)2.95945798
85keratinocyte development (GO:0003334)2.95778529
86cytochrome complex assembly (GO:0017004)2.95683777
87ribosomal small subunit assembly (GO:0000028)2.94537062
88uronic acid metabolic process (GO:0006063)2.94429204
89glucuronate metabolic process (GO:0019585)2.94429204
90NAD biosynthetic process (GO:0009435)2.92956617
91mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.91158306
92pteridine-containing compound biosynthetic process (GO:0042559)2.90980614
93urate metabolic process (GO:0046415)2.90743316
94drug catabolic process (GO:0042737)2.89751622
95cellular ketone body metabolic process (GO:0046950)2.88726327
96pyridine nucleotide biosynthetic process (GO:0019363)2.87777533
97nicotinamide nucleotide biosynthetic process (GO:0019359)2.87777533
98deoxyribose phosphate biosynthetic process (GO:0046385)2.87649984
992-deoxyribonucleotide biosynthetic process (GO:0009265)2.87649984
100positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.86918651
101negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.86167712
102cellular modified amino acid catabolic process (GO:0042219)2.85406920
103blood coagulation, intrinsic pathway (GO:0007597)2.84223630
104folic acid-containing compound metabolic process (GO:0006760)2.83313274
105very-low-density lipoprotein particle assembly (GO:0034379)2.83172922
106positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.83130724
107regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.81353746
108cullin deneddylation (GO:0010388)2.80174624
109thrombin receptor signaling pathway (GO:0070493)2.78884279
110low-density lipoprotein particle remodeling (GO:0034374)2.78782757
111protein heterotetramerization (GO:0051290)2.78271659
112drug transmembrane transport (GO:0006855)2.75044346
113protein maturation by protein folding (GO:0022417)2.74884913
114primary alcohol catabolic process (GO:0034310)2.74641051
115cholesterol homeostasis (GO:0042632)2.74490083
116ether lipid metabolic process (GO:0046485)2.74171686
117L-ascorbic acid metabolic process (GO:0019852)2.72806802
118cholesterol efflux (GO:0033344)2.72555844
119arginine metabolic process (GO:0006525)2.72474381
120xenobiotic catabolic process (GO:0042178)2.70941992
121valine metabolic process (GO:0006573)2.70536458
122flavonoid metabolic process (GO:0009812)2.69262561
123pteridine-containing compound metabolic process (GO:0042558)2.69005301
124sterol homeostasis (GO:0055092)2.68877993
125carboxylic acid catabolic process (GO:0046395)2.68447190
126organic acid catabolic process (GO:0016054)2.68447190
127drug transport (GO:0015893)2.67169832
128disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.66716479
129adenosine metabolic process (GO:0046085)2.65094500
130phospholipid homeostasis (GO:0055091)2.64400998
131DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.62920984
132platelet dense granule organization (GO:0060155)2.62792248
133lactate metabolic process (GO:0006089)2.60603399
134anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.60277871
135positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)2.59056675
136fibrinolysis (GO:0042730)2.58896775
137negative regulation of thymocyte apoptotic process (GO:0070244)2.58544883
138L-methionine salvage (GO:0071267)2.58055554
139L-methionine biosynthetic process (GO:0071265)2.58055554
140amino acid salvage (GO:0043102)2.58055554
141signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.57578742
142signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.57578742
143signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.57578742
144signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.56414068
145intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.56414068
146protein deneddylation (GO:0000338)2.55852897
147negative regulation of ligase activity (GO:0051352)2.53502062
148negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.53502062
149negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.52008473
150regulation of lipoprotein metabolic process (GO:0050746)2.49942733
151telomere maintenance via semi-conservative replication (GO:0032201)2.49561972
152hydrogen peroxide catabolic process (GO:0042744)2.49107686
153response to hydroperoxide (GO:0033194)2.48948372
154membrane budding (GO:0006900)2.48920288
155CENP-A containing nucleosome assembly (GO:0034080)2.48586171
156signal transduction involved in DNA integrity checkpoint (GO:0072401)2.48019758
157signal transduction involved in DNA damage checkpoint (GO:0072422)2.48019758
158pyrimidine nucleoside salvage (GO:0043097)2.45734356
159pyrimidine-containing compound salvage (GO:0008655)2.45734356
160glycerol ether metabolic process (GO:0006662)2.45276307
161mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.44623328
162glutathione metabolic process (GO:0006749)2.43294006
163L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.42700639
164branched-chain amino acid catabolic process (GO:0009083)2.42332544
165signal transduction involved in cell cycle checkpoint (GO:0072395)2.41880240
166establishment of integrated proviral latency (GO:0075713)2.39393734
167positive regulation of glycoprotein biosynthetic process (GO:0010560)2.38379164
168positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.37413171
169purine-containing compound salvage (GO:0043101)2.37071729
170activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.36201846
171chromatin remodeling at centromere (GO:0031055)2.35446860
172negative regulation of coagulation (GO:0050819)2.34711456
173fusion of sperm to egg plasma membrane (GO:0007342)2.34463692
174epoxygenase P450 pathway (GO:0019373)2.33913982
175deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.33220987

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.94477542
2E2F7_22180533_ChIP-Seq_HELA_Human5.34423897
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.97029988
4EGR1_23403033_ChIP-Seq_LIVER_Mouse3.78302353
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.70371648
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.24340581
7* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.99500500
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.83480170
9LXR_22158963_ChIP-Seq_LIVER_Mouse2.78142956
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.75832970
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.66856337
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.35479516
13SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.32399558
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.30219378
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.21392330
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.16355482
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.12754506
18FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.03935958
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.01452430
20IRF8_22096565_ChIP-ChIP_GC-B_Human2.00809770
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.00338847
22GABP_17652178_ChIP-ChIP_JURKAT_Human1.98241502
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.98125315
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.88296137
25PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.86804794
26HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.82914091
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.82718241
28MYC_19030024_ChIP-ChIP_MESCs_Mouse1.81136955
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.80319150
30ETS1_20019798_ChIP-Seq_JURKAT_Human1.73195376
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.71447390
32AR_21909140_ChIP-Seq_LNCAP_Human1.70331906
33MYC_19079543_ChIP-ChIP_MESCs_Mouse1.65632543
34GATA4_25053715_ChIP-Seq_YYC3_Human1.65218198
35* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.62036077
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.60887732
37HTT_18923047_ChIP-ChIP_STHdh_Human1.53283528
38XRN2_22483619_ChIP-Seq_HELA_Human1.50446519
39FOXP3_21729870_ChIP-Seq_TREG_Human1.49554129
40DCP1A_22483619_ChIP-Seq_HELA_Human1.44905820
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.44181952
42VDR_23849224_ChIP-Seq_CD4+_Human1.44075628
43* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41554032
44IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.40937214
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.40120476
46PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.39875467
47CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.39860854
48SOX2_20726797_ChIP-Seq_SW620_Human1.35322719
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.34771572
50STAT3_1855785_ChIP-Seq_MESCs_Mouse1.33540192
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.31720004
52AR_20517297_ChIP-Seq_VCAP_Human1.30497758
53* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30232784
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29605811
55SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.29574418
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29409680
57FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.29278721
58NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.28834645
59* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25941621
60GATA1_22025678_ChIP-Seq_K562_Human1.25828978
61TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25158160
62HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.24260987
63GABP_19822575_ChIP-Seq_HepG2_Human1.23568845
64CDX2_22108803_ChIP-Seq_LS180_Human1.22432425
65MYC_22102868_ChIP-Seq_BL_Human1.21010549
66STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.20450131
67SALL4_18804426_ChIP-ChIP_XEN_Mouse1.20121510
68E2F1_21310950_ChIP-Seq_MCF-7_Human1.16943585
69NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.15465435
70SOX17_20123909_ChIP-Seq_XEN_Mouse1.14341046
71CDX2_20551321_ChIP-Seq_CACO-2_Human1.14054023
72* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12679852
73SALL4_22934838_ChIP-ChIP_CD34+_Human1.12552568
74MYC_18940864_ChIP-ChIP_HL60_Human1.11511505
75IRF8_21731497_ChIP-ChIP_J774_Mouse1.11084292
76FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.10835139
77EGR1_19374776_ChIP-ChIP_THP-1_Human1.09658849
78IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.09599446
79Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.09255921
80* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08971952
81PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08909937
82NANOG_18555785_ChIP-Seq_MESCs_Mouse1.08898532
83FLI1_27457419_Chip-Seq_LIVER_Mouse1.08185157
84POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.07873000
85* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07455672
86* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.07428125
87NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07200774
88NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07200774
89E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.06580488
90HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.06475763
91ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06303045
92NANOG_19829295_ChIP-Seq_ESCs_Human1.05884248
93SOX2_19829295_ChIP-Seq_ESCs_Human1.05884248
94PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05596338
95STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05330866
96FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05201803
97MYB_21317192_ChIP-Seq_ERMYB_Mouse1.04827190
98KDM5A_27292631_Chip-Seq_BREAST_Human1.04732808
99MYCN_18555785_ChIP-Seq_MESCs_Mouse1.04394809
100MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.04355780
101GATA6_25053715_ChIP-Seq_YYC3_Human1.03256827
102FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03150247
103FOXA1_25329375_ChIP-Seq_VCAP_Human1.03150247
104SPI1_23547873_ChIP-Seq_NB4_Human1.02715023
105TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02498538
106RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01902339
107RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.01797490
108ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01711730
109FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01643145
110EWS_26573619_Chip-Seq_HEK293_Human1.00660159
111IGF1R_20145208_ChIP-Seq_DFB_Human1.00574910
112EOMES_21245162_ChIP-Seq_HESCs_Human0.99740406
113MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.98638667
114ELK1_19687146_ChIP-ChIP_HELA_Human0.97741763
115PPAR_26484153_Chip-Seq_NCI-H1993_Human0.97613789
116VDR_21846776_ChIP-Seq_THP-1_Human0.97238251
117TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.97101309
118POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.96419359
119AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96010377
120LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.95398631
121BRD4_27068464_Chip-Seq_AML-cells_Mouse0.95283516
122EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95084855
123CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.94684954
124TTF2_22483619_ChIP-Seq_HELA_Human0.94392435
125EZH2_27294783_Chip-Seq_NPCs_Mouse0.94005449
126ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.93701621
127* CBP_21632823_ChIP-Seq_H3396_Human0.93116541
128YY1_21170310_ChIP-Seq_MESCs_Mouse0.93004639
129GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92852139
130ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.90941509
131GATA2_22383799_ChIP-Seq_G1ME_Mouse0.90754665
132CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90232790
133CJUN_26792858_Chip-Seq_BT549_Human0.89801676
134TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89421576
135STAT4_19710469_ChIP-ChIP_TH1__Mouse0.89111536
136* P300_19829295_ChIP-Seq_ESCs_Human0.88461064
137GBX2_23144817_ChIP-Seq_PC3_Human0.88057448
138ERG_20517297_ChIP-Seq_VCAP_Human0.87084499
139* GATA3_24758297_ChIP-Seq_MCF-7_Human0.87023727
140SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.86980752
141SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.86980752
142GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86586626
143CIITA_25753668_ChIP-Seq_RAJI_Human0.83613308
144BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.83438594
145TFEB_21752829_ChIP-Seq_HELA_Human0.81061861
146NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.81034514
147RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.80890062
148MYB_26560356_Chip-Seq_TH1_Human0.80779250
149SCL_19346495_ChIP-Seq_HPC-7_Human0.80306830
150PADI4_21655091_ChIP-ChIP_MCF-7_Human0.79584462
151KLF4_18555785_ChIP-Seq_MESCs_Mouse0.77105404

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.07849155
2MP0005360_urolithiasis5.90969564
3MP0005085_abnormal_gallbladder_physiolo4.51912294
4MP0005365_abnormal_bile_salt4.38313832
5MP0003806_abnormal_nucleotide_metabolis4.35922690
6MP0008875_abnormal_xenobiotic_pharmacok3.53341125
7MP0000372_irregular_coat_pigmentation3.43053081
8MP0010234_abnormal_vibrissa_follicle3.13512954
9MP0009840_abnormal_foam_cell2.73695002
10MP0003252_abnormal_bile_duct2.71078543
11MP0003136_yellow_coat_color2.58989732
12MP0009780_abnormal_chondrocyte_physiolo2.57224598
13MP0010329_abnormal_lipoprotein_level2.44174584
14MP0001666_abnormal_nutrient_absorption2.17926572
15MP0005083_abnormal_biliary_tract2.17780352
16MP0005332_abnormal_amino_acid2.14603222
17MP0003186_abnormal_redox_activity1.93235065
18MP0003693_abnormal_embryo_hatching1.89755990
19MP0003950_abnormal_plasma_membrane1.88366781
20MP0003191_abnormal_cellular_cholesterol1.81940633
21MP0008004_abnormal_stomach_pH1.79968659
22MP0000609_abnormal_liver_physiology1.79863330
23MP0004019_abnormal_vitamin_homeostasis1.79625155
24MP0010678_abnormal_skin_adnexa1.75266522
25MP0001764_abnormal_homeostasis1.72524695
26MP0001661_extended_life_span1.65711193
27MP0002138_abnormal_hepatobiliary_system1.63665591
28MP0002090_abnormal_vision1.63349689
29MP0003195_calcinosis1.62289759
30MP0005319_abnormal_enzyme/_coenzyme1.60764243
31MP0009697_abnormal_copulation1.49662549
32MP0005379_endocrine/exocrine_gland_phen1.45094180
33MP0001835_abnormal_antigen_presentation1.41407983
34MP0003656_abnormal_erythrocyte_physiolo1.41066618
35MP0004957_abnormal_blastocyst_morpholog1.38800657
36MP0002938_white_spotting1.37269793
37MP0010094_abnormal_chromosome_stability1.35340917
38MP0009643_abnormal_urine_homeostasis1.31390481
39MP0002118_abnormal_lipid_homeostasis1.29504823
40MP0003868_abnormal_feces_composition1.28677481
41MP0003436_decreased_susceptibility_to1.28580728
42MP0004272_abnormal_basement_membrane1.28317868
43MP0002877_abnormal_melanocyte_morpholog1.27471002
44MP0010386_abnormal_urinary_bladder1.27031851
45MP0002163_abnormal_gland_morphology1.26257070
46MP0000598_abnormal_liver_morphology1.25363403
47MP0003111_abnormal_nucleus_morphology1.23532046
48MP0003941_abnormal_skin_development1.23035584
49MP0005451_abnormal_body_composition1.21265130
50MP0002132_abnormal_respiratory_system1.19238140
51MP0005584_abnormal_enzyme/coenzyme_acti1.18754278
52MP0008469_abnormal_protein_level1.18329459
53MP0003011_delayed_dark_adaptation1.18108988
54MP0002396_abnormal_hematopoietic_system1.16882445
55MP0003077_abnormal_cell_cycle1.14343938
56MP0008872_abnormal_physiological_respon1.14288568
57MP0009785_altered_susceptibility_to1.14280716
58MP0000343_altered_response_to1.13232925
59MP0008775_abnormal_heart_ventricle1.11169049
60MP0009763_increased_sensitivity_to1.09958221
61MP0001756_abnormal_urination1.09644444
62MP0002876_abnormal_thyroid_physiology1.08155216
63MP0005395_other_phenotype1.07996556
64MP0005464_abnormal_platelet_physiology1.05302584
65MP0001853_heart_inflammation1.04053539
66MP0008932_abnormal_embryonic_tissue1.02662327
67MP0005408_hypopigmentation1.01652510
68MP0006036_abnormal_mitochondrial_physio1.01123738
69MP0005025_abnormal_response_to1.00558371
70MP0003566_abnormal_cell_adhesion1.00405352
71MP0000685_abnormal_immune_system1.00187148
72MP0001800_abnormal_humoral_immune1.00111778
73MP0000490_abnormal_crypts_of0.99731468
74MP0009764_decreased_sensitivity_to0.99184033
75MP0008057_abnormal_DNA_replication0.98926727
76MP0003638_abnormal_response/metabolism_0.97695474
77MP0000358_abnormal_cell_content/0.97664872
78MP0003724_increased_susceptibility_to0.97261203
79MP0010030_abnormal_orbit_morphology0.96292460
80MP0005248_abnormal_Harderian_gland0.93786128
81MP0003718_maternal_effect0.93492347
82MP0005165_increased_susceptibility_to0.93219268
83MP0000230_abnormal_systemic_arterial0.93057394
84MP0005636_abnormal_mineral_homeostasis0.91731540
85MP0003705_abnormal_hypodermis_morpholog0.90655552
86MP0009333_abnormal_splenocyte_physiolog0.88755612
87MP0010155_abnormal_intestine_physiology0.88451373
88MP0001845_abnormal_inflammatory_respons0.87548876
89MP0000689_abnormal_spleen_morphology0.87411425
90MP0000647_abnormal_sebaceous_gland0.87318230
91MP0000015_abnormal_ear_pigmentation0.87282966
92MP0000383_abnormal_hair_follicle0.86890830
93MP0002419_abnormal_innate_immunity0.86235467
94MP0002295_abnormal_pulmonary_circulatio0.85497365
95MP0008058_abnormal_DNA_repair0.85345410
96MP0005075_abnormal_melanosome_morpholog0.85208305
97MP0006054_spinal_hemorrhage0.84166418
98MP0010352_gastrointestinal_tract_polyps0.84031718
99MP0004264_abnormal_extraembryonic_tissu0.83766571
100MP0005410_abnormal_fertilization0.83675405
101MP0005220_abnormal_exocrine_pancreas0.83009928
102MP0009053_abnormal_anal_canal0.81405879
103MP0009765_abnormal_xenobiotic_induced0.79996993
104MP0002452_abnormal_antigen_presenting0.79899047
105MP0005501_abnormal_skin_physiology0.79805254
106MP0003763_abnormal_thymus_physiology0.79502408
107MP0002722_abnormal_immune_system0.79452771
108MP0005671_abnormal_response_to0.78238810
109MP0006082_CNS_inflammation0.77921484
110MP0002723_abnormal_immune_serum0.77117333
111MP0004147_increased_porphyrin_level0.76305551
112MP0005376_homeostasis/metabolism_phenot0.76080485
113MP0008007_abnormal_cellular_replicative0.74431193
114MP0005084_abnormal_gallbladder_morpholo0.74275379
115MP0002398_abnormal_bone_marrow0.74081826
116MP0002019_abnormal_tumor_incidence0.73942641
117MP0002136_abnormal_kidney_physiology0.73081809
118MP0002429_abnormal_blood_cell0.72715542
119MP0005266_abnormal_metabolism0.72481105
120MP0005000_abnormal_immune_tolerance0.71892432
121MP0001545_abnormal_hematopoietic_system0.71626632
122MP0005397_hematopoietic_system_phenotyp0.71626632
123MP0009642_abnormal_blood_homeostasis0.71033944
124MP0001873_stomach_inflammation0.70488262
125MP0000716_abnormal_immune_system0.69900523
126MP0009379_abnormal_foot_pigmentation0.69619945
127MP0005058_abnormal_lysosome_morphology0.69610663
128MP0004947_skin_inflammation0.69518041
129MP0005023_abnormal_wound_healing0.68288242
130MP0001881_abnormal_mammary_gland0.68266704
131MP0002420_abnormal_adaptive_immunity0.67277749
132MP0005171_absent_coat_pigmentation0.66862549
133MP0001819_abnormal_immune_cell0.66591126
134MP0005387_immune_system_phenotype0.65794460
135MP0001790_abnormal_immune_system0.65794460
136MP0005647_abnormal_sex_gland0.65708492
137MP0000858_altered_metastatic_potential0.65549691
138MP0002254_reproductive_system_inflammat0.65210908
139MP0002148_abnormal_hypersensitivity_rea0.64952527
140MP0002166_altered_tumor_susceptibility0.64791290
141MP0008873_increased_physiological_sensi0.64551833
142MP0002837_dystrophic_cardiac_calcinosis0.64347555
143MP0002909_abnormal_adrenal_gland0.62472089
144MP0005197_abnormal_uvea_morphology0.58559901
145MP0000427_abnormal_hair_cycle0.58130790
146MP0001851_eye_inflammation0.57661049
147MP0003786_premature_aging0.57250178
148MP0005174_abnormal_tail_pigmentation0.56949694
149MP0006072_abnormal_retinal_apoptosis0.55978787

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of monocarboxylic acid metabolism (HP:0010996)5.55340672
2Abnormality of aromatic amino acid family metabolism (HP:0004338)5.54159117
3Petechiae (HP:0000967)5.54099203
4Intrahepatic cholestasis (HP:0001406)5.48834042
5Hypobetalipoproteinemia (HP:0003563)5.31922515
6Deep venous thrombosis (HP:0002625)4.79343986
7Prolonged partial thromboplastin time (HP:0003645)4.52438998
8Xanthomatosis (HP:0000991)4.43719747
9Abnormality of pyrimidine metabolism (HP:0004353)4.14788387
10Hyperammonemia (HP:0001987)3.83749327
11Hepatocellular necrosis (HP:0001404)3.63112651
12Hyperglycinemia (HP:0002154)3.62346969
13Hypolipoproteinemia (HP:0010981)3.59521676
14Hyperlipoproteinemia (HP:0010980)3.59085836
15Abnormality of aspartate family amino acid metabolism (HP:0010899)3.53629553
16Abnormality of sulfur amino acid metabolism (HP:0004339)3.53612218
17Joint hemorrhage (HP:0005261)3.52740442
18Abnormality of glutamine family amino acid metabolism (HP:0010902)3.51063424
19Abnormality of methionine metabolism (HP:0010901)3.50201974
20Hyperglycinuria (HP:0003108)3.41099873
21Fat malabsorption (HP:0002630)3.40353449
22Abnormality of glycine metabolism (HP:0010895)3.32377224
23Abnormality of serine family amino acid metabolism (HP:0010894)3.32377224
24Hypoglycemic coma (HP:0001325)3.29721940
253-Methylglutaconic aciduria (HP:0003535)3.28206269
26Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.25575476
27Complement deficiency (HP:0004431)3.24093947
28Abnormality of the common coagulation pathway (HP:0010990)3.22920136
29Acute encephalopathy (HP:0006846)3.09358908
30Purpura (HP:0000979)3.05541921
31Increased CSF lactate (HP:0002490)3.05541856
32Hyperbilirubinemia (HP:0002904)3.04714277
33Mitochondrial inheritance (HP:0001427)3.02122261
34Abnormality of fatty-acid metabolism (HP:0004359)3.01035504
35Epidermoid cyst (HP:0200040)2.99772646
36Ketosis (HP:0001946)2.96224735
37Dyschromatopsia (HP:0007641)2.93723175
38Acute necrotizing encephalopathy (HP:0006965)2.91821409
39Abnormality of the intrinsic pathway (HP:0010989)2.87782274
40Abnormality of nucleobase metabolism (HP:0010932)2.83157869
41Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.82823897
42Abnormality of serum amino acid levels (HP:0003112)2.82543970
43Abnormality of the anterior horn cell (HP:0006802)2.82260906
44Degeneration of anterior horn cells (HP:0002398)2.82260906
45Prolonged bleeding time (HP:0003010)2.71851692
46Abnormal mitochondria in muscle tissue (HP:0008316)2.70980185
47Steatorrhea (HP:0002570)2.70345248
48Conjugated hyperbilirubinemia (HP:0002908)2.69448452
49Hypercholesterolemia (HP:0003124)2.65174458
50Abnormality of dicarboxylic acid metabolism (HP:0010995)2.64972246
51Dicarboxylic aciduria (HP:0003215)2.64972246
52Hypoalphalipoproteinemia (HP:0003233)2.63957014
53Abnormality of complement system (HP:0005339)2.62539234
54Progressive macrocephaly (HP:0004481)2.62254805
55CNS demyelination (HP:0007305)2.57720058
56Aplasia/Hypoplasia of the fovea (HP:0008060)2.57071109
57Hypoplasia of the fovea (HP:0007750)2.57071109
58Hepatocellular carcinoma (HP:0001402)2.56192560
59Abnormal pupillary function (HP:0007686)2.50440609
60Generalized aminoaciduria (HP:0002909)2.48061029
61Renal Fanconi syndrome (HP:0001994)2.47777060
62Lethargy (HP:0001254)2.41995641
63Nausea (HP:0002018)2.41772064
64Spastic diplegia (HP:0001264)2.41195085
65Reduced antithrombin III activity (HP:0001976)2.37052870
66Delayed CNS myelination (HP:0002188)2.37020010
67Recurrent gram-negative bacterial infections (HP:0005420)2.34003271
68Cardiovascular calcification (HP:0011915)2.33115683
69Hydroxyprolinuria (HP:0003080)2.32556747
70Abnormality of proline metabolism (HP:0010907)2.32556747
71Lactic acidosis (HP:0003128)2.30691817
72Respiratory failure (HP:0002878)2.29945669
73Hypokinesia (HP:0002375)2.29841460
74Increased hepatocellular lipid droplets (HP:0006565)2.29831030
75Metabolic acidosis (HP:0001942)2.29330589
76Hypophosphatemic rickets (HP:0004912)2.28513439
77Acanthocytosis (HP:0001927)2.28102836
78Sparse eyelashes (HP:0000653)2.27256633
79Hypochromic microcytic anemia (HP:0004840)2.26012496
80Posterior subcapsular cataract (HP:0007787)2.24473024
81Reticulocytopenia (HP:0001896)2.23039163
82Increased serum lactate (HP:0002151)2.18051934
83Abnormality of purine metabolism (HP:0004352)2.17342610
84Increased serum pyruvate (HP:0003542)2.17100374
85Myocardial infarction (HP:0001658)2.16656659
86Vacuolated lymphocytes (HP:0001922)2.15749710
87Cerebral edema (HP:0002181)2.15125034
88Abnormality of iron homeostasis (HP:0011031)2.15056387
89Impaired platelet aggregation (HP:0003540)2.13225083
90Abnormal platelet function (HP:0011869)2.13225083
91Abnormality of the fovea (HP:0000493)2.12142289
92Abnormality of transition element cation homeostasis (HP:0011030)2.11791904
93Symptomatic seizures (HP:0011145)2.11539531
94Gingival bleeding (HP:0000225)2.11040549
95Proximal tubulopathy (HP:0000114)2.10395683
96Abnormality of glycolysis (HP:0004366)2.10125544
97Decreased activity of mitochondrial respiratory chain (HP:0008972)2.08128495
98Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.08128495
99Megaloblastic anemia (HP:0001889)2.07755483
100Abnormal auditory evoked potentials (HP:0006958)2.06782379
101Congenital sensorineural hearing impairment (HP:0008527)2.04889517
102Opisthotonus (HP:0002179)2.04485489
103Abnormality of alanine metabolism (HP:0010916)2.04416151
104Hyperalaninemia (HP:0003348)2.04416151
105Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.04416151
106Systemic lupus erythematosus (HP:0002725)2.03188728
107Glycosuria (HP:0003076)2.02580452
108Abnormality of urine glucose concentration (HP:0011016)2.02580452
109Macrocytic anemia (HP:0001972)2.02513857
110Oral leukoplakia (HP:0002745)2.01681915
111Type I transferrin isoform profile (HP:0003642)2.00891056
112Abnormality of vitamin B metabolism (HP:0004340)2.00852701
113Lipid accumulation in hepatocytes (HP:0006561)1.99839241
114Biliary tract neoplasm (HP:0100574)1.98377964
115Poikilocytosis (HP:0004447)1.97945104
116Renal cortical cysts (HP:0000803)1.96622666
117Hypothermia (HP:0002045)1.95664317
118Pancreatitis (HP:0001733)1.94684478
119Increased serum ferritin (HP:0003281)1.93315540
120Hyperphosphaturia (HP:0003109)1.93155412
121Hepatic necrosis (HP:0002605)1.92906142
122Esophageal varix (HP:0002040)1.92893455
123Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.92536570
124Albinism (HP:0001022)1.92432439
125Patchy hypopigmentation of hair (HP:0011365)1.91694325
126Thrombocytosis (HP:0001894)1.91455489
127Malnutrition (HP:0004395)1.91024723
128Thrombophlebitis (HP:0004418)1.90481325
129Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.89749251
130Vascular calcification (HP:0004934)1.89457063
131Abnormal number of erythroid precursors (HP:0012131)1.88862600
132Abnormality of cells of the erythroid lineage (HP:0012130)1.88346528
133Hyperinsulinemic hypoglycemia (HP:0000825)1.87924722
134Abnormality of the vitamin B12 metabolism (HP:0004341)1.87836424
135Abnormal hemoglobin (HP:0011902)1.87515817
136Elevated hepatic transaminases (HP:0002910)1.86709675
137Mitral stenosis (HP:0001718)1.85572999
138Spontaneous abortion (HP:0005268)1.83906683
139Pancreatic islet-cell hyperplasia (HP:0004510)1.83538018
140Abnormality of reticulocytes (HP:0004312)1.82575718
141Multiple enchondromatosis (HP:0005701)1.82498995
142Menorrhagia (HP:0000132)1.82287378
143Vomiting (HP:0002013)1.82006006
144Irritability (HP:0000737)1.81331057
145Abnormal cartilage morphology (HP:0002763)1.79961807
146Ketoacidosis (HP:0001993)1.79960450
147Abnormal platelet volume (HP:0011876)1.79684625
148Increased mean platelet volume (HP:0011877)1.79289016
149Hypochromic anemia (HP:0001931)1.79043409
150Abnormal enzyme/coenzyme activity (HP:0012379)1.78623333
151Glomerulonephritis (HP:0000099)1.76497800
152Abnormality of the heme biosynthetic pathway (HP:0010472)1.74730678
153Hypoglycemic seizures (HP:0002173)1.73416947
154Late onset (HP:0003584)1.72637760
155Epistaxis (HP:0000421)1.71348712
156Microcytic anemia (HP:0001935)1.70022435
157Brushfield spots (HP:0001088)1.64454352
158Nonimmune hydrops fetalis (HP:0001790)1.64013572
159Autoimmune thrombocytopenia (HP:0001973)1.62322093

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK3.76668936
2EIF2AK12.96685408
3MAP3K122.96456743
4PDK22.72163322
5NME22.66378934
6TRIM282.54358150
7MYLK2.43768287
8BMPR1B2.35563438
9BUB12.32285076
10ERN12.29153773
11PBK2.25971789
12MAP4K12.21599567
13WEE12.10645418
14NUAK12.04962209
15VRK22.04856030
16FLT31.95512686
17STK161.91433798
18EIF2AK31.88092479
19TLK11.85704011
20TESK21.84528402
21STK241.83094561
22CDC71.80507142
23FGFR41.79629272
24RPS6KA41.78210681
25ACVR1B1.69230796
26BLK1.67751205
27TYK21.62054333
28KDR1.55953896
29TNIK1.52512125
30PLK21.48162646
31STK101.45800441
32MAP3K101.43507208
33SIK11.41849206
34NEK21.39546494
35TAOK31.39161659
36IRAK31.39111283
37PIM21.38334631
38PKN21.36786061
39PLK31.34084092
40TBK11.33658851
41GRK61.32395222
42BCR1.31582976
43MAP4K21.26074269
44ERBB31.25538965
45PLK41.25193277
46TTK1.23993145
47MAPKAPK31.22469866
48STK41.22194387
49CDK41.20215823
50MAP3K111.19216923
51BTK1.16970600
52PIM11.16805625
53CSF1R1.15546538
54RPS6KB21.14964407
55MAP3K141.13964346
56MAP2K31.12272544
57MAP3K81.12134471
58TEC1.10912391
59ILK1.10589897
60DYRK31.09760146
61CDK71.09302237
62BRSK21.09256514
63MAPK111.08016097
64AURKB1.07602027
65MET1.07548601
66GRK11.07369204
67VRK11.04800570
68LRRK21.04405895
69KIT1.03899607
70ADRBK21.03677395
71EPHA21.03312538
72PIK3CG1.03265531
73MAP3K31.02002992
74NEK90.99898808
75SRPK10.97538776
76ZAP700.96683609
77NEK10.96150599
78MUSK0.96077553
79PLK10.95151101
80SIK30.94454648
81LMTK20.94234623
82IRAK40.93003102
83JAK30.91577135
84ATR0.91303346
85TXK0.90834593
86BMPR20.89993217
87CSNK1G10.87916049
88IKBKB0.86306343
89CSNK1G30.85088505
90FER0.84582795
91BMX0.83336065
92SCYL20.83087643
93DAPK10.81551635
94IKBKE0.80849524
95LIMK10.80747155
96FRK0.79002753
97ABL20.78947322
98PTK2B0.77679792
99CDK60.77481555
100TAF10.74269402
101EIF2AK20.72408555
102PAK40.72226298
103EEF2K0.70745569
104PASK0.68736056
105LYN0.67364228
106DAPK30.67101770
107PTK60.66692372
108ITK0.64933678
109ARAF0.64869705
110TGFBR20.64323051
111OXSR10.64124785
112GRK50.63543676
113MKNK10.63145202
114STK390.62823503
115CSK0.62357476
116MST1R0.61967900
117ZAK0.60667327
118ERBB40.60107690
119TGFBR10.60053339
120AURKA0.59412790
121NLK0.59230216
122TRIB30.58411510
123PAK10.57873423
124TAOK20.57345238
125SYK0.56419630
126CHUK0.53789705
127MST40.51944764
128MELK0.51740697
129TESK10.51557419
130CDK80.51074350
131CSNK1G20.50585457
132JAK20.49152683
133CSNK2A10.48996863
134BRSK10.47637266
135WNK30.47314659
136CDK120.46768132
137RPS6KA50.44589469
138STK38L0.44441008
139CSNK1A1L0.43816083
140CLK10.43269241
141CSNK2A20.42710964
142PRKCE0.42638251
143LCK0.42110686
144MAP2K20.41562341
145MAP2K60.40848797
146STK30.40169234
147MKNK20.37658572
148TRPM70.37578112
149ADRBK10.36048756
150MINK10.32365244
151ROCK10.31439993
152IGF1R0.27138625
153MOS0.27030767
154PRKCI0.26220580

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.31654808
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.01930475
3Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.31673775
4Pentose and glucuronate interconversions_Homo sapiens_hsa000402.30153563
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.25996177
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.20308634
7Tryptophan metabolism_Homo sapiens_hsa003802.13628503
8Arginine biosynthesis_Homo sapiens_hsa002202.10229155
9Nitrogen metabolism_Homo sapiens_hsa009102.08861425
10One carbon pool by folate_Homo sapiens_hsa006702.08477290
11Drug metabolism - other enzymes_Homo sapiens_hsa009832.04469759
12Fatty acid degradation_Homo sapiens_hsa000712.02870773
13Folate biosynthesis_Homo sapiens_hsa007901.93092412
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.92788611
15Complement and coagulation cascades_Homo sapiens_hsa046101.90822397
16Selenocompound metabolism_Homo sapiens_hsa004501.85941557
17DNA replication_Homo sapiens_hsa030301.84839671
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.82658619
19Peroxisome_Homo sapiens_hsa041461.78937665
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.74357903
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.73998368
22Chemical carcinogenesis_Homo sapiens_hsa052041.70494400
23Oxidative phosphorylation_Homo sapiens_hsa001901.69021636
24Histidine metabolism_Homo sapiens_hsa003401.60161558
25Sulfur relay system_Homo sapiens_hsa041221.57043214
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.56478293
27Caffeine metabolism_Homo sapiens_hsa002321.54328463
28Ribosome_Homo sapiens_hsa030101.50873023
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.50806324
30Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.47012898
31Retinol metabolism_Homo sapiens_hsa008301.46708026
32Propanoate metabolism_Homo sapiens_hsa006401.45715662
33Staphylococcus aureus infection_Homo sapiens_hsa051501.44237352
34beta-Alanine metabolism_Homo sapiens_hsa004101.43737128
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.42952731
36Parkinsons disease_Homo sapiens_hsa050121.42602139
37Mismatch repair_Homo sapiens_hsa034301.40862802
38Butanoate metabolism_Homo sapiens_hsa006501.35962008
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.34628352
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33674835
41Biosynthesis of amino acids_Homo sapiens_hsa012301.33255921
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.28878645
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.28677608
44Proteasome_Homo sapiens_hsa030501.26180110
45PPAR signaling pathway_Homo sapiens_hsa033201.25489254
46SNARE interactions in vesicular transport_Homo sapiens_hsa041301.23480671
47Carbon metabolism_Homo sapiens_hsa012001.23223952
48Fatty acid metabolism_Homo sapiens_hsa012121.22974556
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.22188986
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17531552
51Glutathione metabolism_Homo sapiens_hsa004801.16891836
52Phenylalanine metabolism_Homo sapiens_hsa003601.13405643
53Pyruvate metabolism_Homo sapiens_hsa006201.12819486
54Starch and sucrose metabolism_Homo sapiens_hsa005001.10404617
55Sulfur metabolism_Homo sapiens_hsa009201.09490296
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.08352389
57* Pentose phosphate pathway_Homo sapiens_hsa000301.07618812
58Fat digestion and absorption_Homo sapiens_hsa049751.07013779
59Sphingolipid metabolism_Homo sapiens_hsa006001.06811988
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.05620462
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.04892295
62Pyrimidine metabolism_Homo sapiens_hsa002401.03904183
63Tyrosine metabolism_Homo sapiens_hsa003501.03138236
64Steroid biosynthesis_Homo sapiens_hsa001000.99979288
65Vitamin digestion and absorption_Homo sapiens_hsa049770.96976691
66Base excision repair_Homo sapiens_hsa034100.96498031
67Glycosaminoglycan degradation_Homo sapiens_hsa005310.96451798
68Arachidonic acid metabolism_Homo sapiens_hsa005900.94895780
69Fatty acid elongation_Homo sapiens_hsa000620.92288855
70Arginine and proline metabolism_Homo sapiens_hsa003300.92246034
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.87204153
72ABC transporters_Homo sapiens_hsa020100.86231041
73Huntingtons disease_Homo sapiens_hsa050160.85237532
74Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.82629352
75Homologous recombination_Homo sapiens_hsa034400.81767877
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80426917
77Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.79664233
78Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.77405674
79Renin-angiotensin system_Homo sapiens_hsa046140.77227919
80Nucleotide excision repair_Homo sapiens_hsa034200.76399134
81Bile secretion_Homo sapiens_hsa049760.75768772
82Collecting duct acid secretion_Homo sapiens_hsa049660.73894771
83Alzheimers disease_Homo sapiens_hsa050100.72216427
84Basal transcription factors_Homo sapiens_hsa030220.70463008
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.65907303
86Spliceosome_Homo sapiens_hsa030400.64781455
87Lysine degradation_Homo sapiens_hsa003100.64744773
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64581107
89Vitamin B6 metabolism_Homo sapiens_hsa007500.63935985
90N-Glycan biosynthesis_Homo sapiens_hsa005100.62470112
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61963217
92Mineral absorption_Homo sapiens_hsa049780.61059799
93Non-homologous end-joining_Homo sapiens_hsa034500.61036419
94RNA polymerase_Homo sapiens_hsa030200.59389298
95Systemic lupus erythematosus_Homo sapiens_hsa053220.58260343
96Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58068316
97Metabolic pathways_Homo sapiens_hsa011000.56972267
98Galactose metabolism_Homo sapiens_hsa000520.56166592
99Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56019557
100Fructose and mannose metabolism_Homo sapiens_hsa000510.53619008
101RNA transport_Homo sapiens_hsa030130.48010108
102Primary immunodeficiency_Homo sapiens_hsa053400.45571771
103Cell cycle_Homo sapiens_hsa041100.40458940
104Legionellosis_Homo sapiens_hsa051340.39954015
105Glycerolipid metabolism_Homo sapiens_hsa005610.37506754
106Fanconi anemia pathway_Homo sapiens_hsa034600.36840355
107Protein export_Homo sapiens_hsa030600.36581310
108Antigen processing and presentation_Homo sapiens_hsa046120.35452596
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34734666
110Vibrio cholerae infection_Homo sapiens_hsa051100.32661075
111Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.32362077
112Intestinal immune network for IgA production_Homo sapiens_hsa046720.31873274
113Herpes simplex infection_Homo sapiens_hsa051680.30462150
114Platelet activation_Homo sapiens_hsa046110.30443749
115p53 signaling pathway_Homo sapiens_hsa041150.30427868
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30178133
117RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.25724756
118RNA degradation_Homo sapiens_hsa030180.23500026
119NF-kappa B signaling pathway_Homo sapiens_hsa040640.23310752
120Purine metabolism_Homo sapiens_hsa002300.22861218
121Other glycan degradation_Homo sapiens_hsa005110.22641417
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20696313
123Linoleic acid metabolism_Homo sapiens_hsa005910.19720102

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