DERL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the derlin family. Members of this family participate in the ER-associated degradation response and retrotranslocate misfolded or unfolded proteins from the ER lumen to the cytosol for proteasomal degradation. This protein recognizes substrate in the ER and works in a complex to retrotranslocate it across the ER membrane into the cytosol. This protein may select cystic fibrosis transmembrane conductance regulator protein (CFTR) for degradation as well as unfolded proteins in Alzheimer's disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)4.69225195
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.69225195
3L-phenylalanine metabolic process (GO:0006558)4.65571446
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.65571446
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.49648678
6alpha-linolenic acid metabolic process (GO:0036109)4.45854689
7valine metabolic process (GO:0006573)4.38526848
8low-density lipoprotein particle clearance (GO:0034383)4.21855653
9gonadal mesoderm development (GO:0007506)4.21176385
10sulfur amino acid catabolic process (GO:0000098)4.06481357
11complement activation, alternative pathway (GO:0006957)4.03220416
12peptidyl-glutamic acid carboxylation (GO:0017187)3.94333062
13protein carboxylation (GO:0018214)3.94333062
14cysteine metabolic process (GO:0006534)3.93683150
15plasma lipoprotein particle clearance (GO:0034381)3.88086762
16aromatic amino acid family catabolic process (GO:0009074)3.86853130
17Golgi transport vesicle coating (GO:0048200)3.82271793
18COPI coating of Golgi vesicle (GO:0048205)3.82271793
19fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.74310114
20regulation of triglyceride catabolic process (GO:0010896)3.74274087
21lysine catabolic process (GO:0006554)3.69212592
22lysine metabolic process (GO:0006553)3.69212592
23regulation of protein activation cascade (GO:2000257)3.60296862
24high-density lipoprotein particle remodeling (GO:0034375)3.55851120
25positive regulation of keratinocyte differentiation (GO:0045618)3.53320917
26regulation of complement activation (GO:0030449)3.48210570
27reverse cholesterol transport (GO:0043691)3.48190796
28COPII vesicle coating (GO:0048208)3.46983713
29glyoxylate metabolic process (GO:0046487)3.45420941
30negative regulation of fibrinolysis (GO:0051918)3.44031949
31regulation of cholesterol homeostasis (GO:2000188)3.39527387
32antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.38835240
33antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.38835240
34bile acid biosynthetic process (GO:0006699)3.36379200
35kynurenine metabolic process (GO:0070189)3.32359475
36positive regulation of triglyceride metabolic process (GO:0090208)3.29834275
37urea cycle (GO:0000050)3.28014654
38urea metabolic process (GO:0019627)3.28014654
39protein-lipid complex remodeling (GO:0034368)3.27950372
40macromolecular complex remodeling (GO:0034367)3.27950372
41plasma lipoprotein particle remodeling (GO:0034369)3.27950372
42retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.27771134
434-hydroxyproline metabolic process (GO:0019471)3.27701564
44positive regulation of fatty acid beta-oxidation (GO:0032000)3.27387595
45homocysteine metabolic process (GO:0050667)3.25687444
46cellular modified amino acid catabolic process (GO:0042219)3.24353635
47tryptophan catabolic process (GO:0006569)3.21413211
48indole-containing compound catabolic process (GO:0042436)3.21413211
49indolalkylamine catabolic process (GO:0046218)3.21413211
50maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.20857230
51triglyceride homeostasis (GO:0070328)3.20359232
52acylglycerol homeostasis (GO:0055090)3.20359232
53fatty acid beta-oxidation (GO:0006635)3.18925953
54phospholipid efflux (GO:0033700)3.18850715
55tricarboxylic acid metabolic process (GO:0072350)3.16129205
56regulation of cholesterol storage (GO:0010885)3.14488519
57fatty acid oxidation (GO:0019395)3.13064789
58plasma lipoprotein particle assembly (GO:0034377)3.11275886
59lipoprotein metabolic process (GO:0042157)3.10572475
60lipid oxidation (GO:0034440)3.10087671
61tryptophan metabolic process (GO:0006568)3.10041168
62ER overload response (GO:0006983)3.09563332
63positive regulation of triglyceride biosynthetic process (GO:0010867)3.09383444
64regulation of fibrinolysis (GO:0051917)3.08755797
65amino-acid betaine metabolic process (GO:0006577)3.08533122
66protein-lipid complex assembly (GO:0065005)3.08435427
67protein localization to endosome (GO:0036010)3.08128728
68regulation of cholesterol esterification (GO:0010872)3.07690422
69ethanol oxidation (GO:0006069)3.06746983
702-oxoglutarate metabolic process (GO:0006103)3.06111307
71complement activation (GO:0006956)3.04624943
72nitrogen cycle metabolic process (GO:0071941)3.04168089
73positive regulation of lipid catabolic process (GO:0050996)3.02851117
74complement activation, classical pathway (GO:0006958)3.01608874
75regulation of triglyceride metabolic process (GO:0090207)3.00279857
76tyrosine metabolic process (GO:0006570)3.00267984
77regulation of fatty acid beta-oxidation (GO:0031998)3.00196434
78short-chain fatty acid metabolic process (GO:0046459)2.97574675
79bile acid metabolic process (GO:0008206)2.97492570
80proline biosynthetic process (GO:0006561)2.97218716
81fatty acid catabolic process (GO:0009062)2.97043730
82regulation of cholesterol biosynthetic process (GO:0045540)2.96385428
83regulation of cholesterol metabolic process (GO:0090181)2.96130379
84pentose-phosphate shunt (GO:0006098)2.90269185
85cholesterol efflux (GO:0033344)2.89841686
86regulation of triglyceride biosynthetic process (GO:0010866)2.88308878
87acetyl-CoA metabolic process (GO:0006084)2.87937811
88aromatic amino acid family metabolic process (GO:0009072)2.87755647
89negative regulation of sterol transport (GO:0032372)2.87245553
90negative regulation of cholesterol transport (GO:0032375)2.87245553
91plasma lipoprotein particle organization (GO:0071827)2.87242480
92protein-lipid complex subunit organization (GO:0071825)2.87143724
93antigen processing and presentation of endogenous antigen (GO:0019883)2.86979490
94negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.85973045
95coenzyme catabolic process (GO:0009109)2.85455779
96hepatocyte apoptotic process (GO:0097284)2.85361547
97positive regulation of fatty acid oxidation (GO:0046321)2.85076740
98vesicle coating (GO:0006901)2.84705385
99positive regulation of fatty acid biosynthetic process (GO:0045723)2.84028802
100regulation of sequestering of triglyceride (GO:0010889)2.83326919
101branched-chain amino acid metabolic process (GO:0009081)2.82927146
102serine family amino acid catabolic process (GO:0009071)2.82733779
103phospholipid homeostasis (GO:0055091)2.82707637
104activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.82417939
105apoptotic cell clearance (GO:0043277)2.82363487
106intestinal cholesterol absorption (GO:0030299)2.81880272
107protein retention in ER lumen (GO:0006621)2.81439020
108protein activation cascade (GO:0072376)2.81319520
109low-density lipoprotein particle remodeling (GO:0034374)2.79663352
110* endoplasmic reticulum unfolded protein response (GO:0030968)2.76027334
111NIK/NF-kappaB signaling (GO:0038061)2.74791009
112* ER-nucleus signaling pathway (GO:0006984)2.72196650
113positive regulation of nuclease activity (GO:0032075)2.70818238
114mannose metabolic process (GO:0006013)2.69267772
115positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.66114966
116negative regulation of necroptotic process (GO:0060546)2.65114085
117regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.64565010
118positive regulation of epidermal cell differentiation (GO:0045606)2.62555801
119amyloid precursor protein catabolic process (GO:0042987)2.61770532
120cell adhesion mediated by integrin (GO:0033627)2.61256269
121regulation of metalloenzyme activity (GO:0048552)2.60859020
122membrane raft organization (GO:0031579)2.59036186
123membrane budding (GO:0006900)2.57775233
124positive regulation of Cdc42 GTPase activity (GO:0043089)2.57246227
125negative regulation of protein localization to plasma membrane (GO:1903077)2.56875160
126hemidesmosome assembly (GO:0031581)2.56765587
127* cellular response to unfolded protein (GO:0034620)2.54554207
128desmosome organization (GO:0002934)2.52546524
129regulation of nuclease activity (GO:0032069)2.52349458
130regulation of vitamin D biosynthetic process (GO:0060556)2.50278385
131pinocytosis (GO:0006907)2.48838093
132regulation of vitamin metabolic process (GO:0030656)2.44192206
133regulation of histone H3-K27 methylation (GO:0061085)2.42449613
134skin morphogenesis (GO:0043589)2.41960464
135regulation of necroptotic process (GO:0060544)2.38249034
136NADH metabolic process (GO:0006734)2.36299485
137regulation of defense response to virus by virus (GO:0050690)2.34462355
138mammary gland epithelial cell proliferation (GO:0033598)2.32726840
139interferon-gamma secretion (GO:0072643)2.32000217
140nucleotide-sugar biosynthetic process (GO:0009226)2.31306499
141embryonic process involved in female pregnancy (GO:0060136)2.30288571
142sphingosine metabolic process (GO:0006670)2.29820717
143response to peptidoglycan (GO:0032494)2.29562262
144protein N-linked glycosylation via asparagine (GO:0018279)2.29082321
145localization within membrane (GO:0051668)2.26724555
146peptidyl-asparagine modification (GO:0018196)2.26578696
147* cellular response to topologically incorrect protein (GO:0035967)2.26420317
148lipopolysaccharide-mediated signaling pathway (GO:0031663)2.25890243
149intestinal epithelial cell development (GO:0060576)2.25749820
150hypotonic response (GO:0006971)2.25723814
151regulation of glucose import in response to insulin stimulus (GO:2001273)2.25229455
152* response to endoplasmic reticulum stress (GO:0034976)2.24162812
153regulation of type I interferon-mediated signaling pathway (GO:0060338)2.21945709
154hyaluronan catabolic process (GO:0030214)2.21879873
155amyloid precursor protein metabolic process (GO:0042982)2.21736001
156protein N-linked glycosylation (GO:0006487)2.20516670
157regulation of necrotic cell death (GO:0010939)2.17616800
158membrane protein ectodomain proteolysis (GO:0006509)2.16675712
159ribosome assembly (GO:0042255)2.13185065
160formation of translation preinitiation complex (GO:0001731)2.13123676
161regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.12673016
162type I interferon signaling pathway (GO:0060337)2.12341586
163cellular response to type I interferon (GO:0071357)2.12341586
164negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.11590279
165chaperone mediated protein folding requiring cofactor (GO:0051085)2.11524603
166regulation of response to interferon-gamma (GO:0060330)2.10477382
167response to thyroid hormone (GO:0097066)2.09764610
168cellular response to thyroid hormone stimulus (GO:0097067)2.09239157
169response to type I interferon (GO:0034340)2.08460477
170branching involved in mammary gland duct morphogenesis (GO:0060444)2.08420491
171diol metabolic process (GO:0034311)2.08245419
172glycosphingolipid catabolic process (GO:0046479)2.07227315
173iron ion import (GO:0097286)2.07121631
174programmed necrotic cell death (GO:0097300)2.06814799
175regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.06131012
176proline metabolic process (GO:0006560)2.04794580
177regulation of keratinocyte differentiation (GO:0045616)2.04459206
178necroptotic process (GO:0070266)2.04114778
179N-acetylneuraminate metabolic process (GO:0006054)2.02946692
180endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.02074781
181protein maturation by protein folding (GO:0022417)2.01621599
182myeloid dendritic cell differentiation (GO:0043011)2.01545136
183barbed-end actin filament capping (GO:0051016)2.01371949
184positive regulation of pseudopodium assembly (GO:0031274)1.99670526
185negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)1.98152181
186positive regulation of endothelial cell apoptotic process (GO:2000353)1.97300046
187negative regulation of fatty acid biosynthetic process (GO:0045717)1.97218002
188regulation of syncytium formation by plasma membrane fusion (GO:0060142)1.96823994
189stress fiber assembly (GO:0043149)1.96020313

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.16830374
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.69552968
3* RXR_22158963_ChIP-Seq_LIVER_Mouse5.19194830
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.67129495
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.04224208
6* EGR1_23403033_ChIP-Seq_LIVER_Mouse3.26904238
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.11904255
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.07669524
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.96682251
10CLOCK_20551151_ChIP-Seq_293T_Human2.91990811
11GATA1_22025678_ChIP-Seq_K562_Human2.64362999
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.60376144
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.48678676
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.29032720
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.25977640
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.24025143
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.10051050
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.05169946
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.99778079
20RARG_19884340_ChIP-ChIP_MEFs_Mouse1.98176532
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.86517550
22SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.83641966
23NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.81582676
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.80078234
25ESR1_20079471_ChIP-ChIP_T-47D_Human1.65514367
26HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.64905732
27DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.62914625
28STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.61056888
29SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.60352803
30* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.59677149
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.58609330
32STAT4_19710469_ChIP-ChIP_TH1__Mouse1.56727886
33SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.55702440
34SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.55702440
35E2F7_22180533_ChIP-Seq_HELA_Human1.55478934
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.52623065
37MYB_21317192_ChIP-Seq_ERMYB_Mouse1.52440725
38* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47451578
39CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.46504062
40IRF8_27001747_Chip-Seq_BMDM_Mouse1.46285799
41PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.45744825
42NELFA_20434984_ChIP-Seq_ESCs_Mouse1.44761980
43DCP1A_22483619_ChIP-Seq_HELA_Human1.44192196
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.43880219
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.43318609
46IRF8_21731497_ChIP-ChIP_J774_Mouse1.43089215
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.42684701
48BP1_19119308_ChIP-ChIP_Hs578T_Human1.42441978
49HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.42317165
50TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41995222
51HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.39175739
52RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.38136223
53STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.37368953
54MYC_18555785_ChIP-Seq_MESCs_Mouse1.37110010
55LXR_22292898_ChIP-Seq_THP-1_Human1.36692888
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35575680
57* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.35148075
58* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.31437719
59KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31291911
60KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.30234267
61TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29617001
62AR_21909140_ChIP-Seq_LNCAP_Human1.29407968
63GATA1_19941826_ChIP-Seq_K562_Human1.29101003
64EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.29028699
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27886971
66IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.24628073
67VDR_21846776_ChIP-Seq_THP-1_Human1.24528228
68Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.24255210
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23790673
70* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.23707496
71ELK3_25401928_ChIP-Seq_HUVEC_Human1.23191859
72SOX2_27498859_Chip-Seq_STOMACH_Mouse1.20803180
73IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.20347386
74TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18773913
75* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.18498940
76SCL_19346495_ChIP-Seq_HPC-7_Human1.17638472
77TRIM28_21343339_ChIP-Seq_HEK293_Human1.16890196
78ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16861058
79TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.16068127
80ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.15763221
81* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15522289
82PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.13931193
83FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.13006142
84* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.12962821
85MYC_22102868_ChIP-Seq_BL_Human1.10020786
86EGR1_19374776_ChIP-ChIP_THP-1_Human1.10003806
87MAF_26560356_Chip-Seq_TH1_Human1.09309934
88JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.08868862
89KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07523817
90FOXA2_19822575_ChIP-Seq_HepG2_Human1.07461479
91EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.07415409
92VDR_24763502_ChIP-Seq_THP-1_Human1.07265912
93ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06137918
94STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05752840
95FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05751068
96MYCN_18555785_ChIP-Seq_MESCs_Mouse1.05714639
97ZNF263_19887448_ChIP-Seq_K562_Human1.04928956
98GATA1_19941827_ChIP-Seq_MEL_Mouse1.03678855
99FOXO3_23340844_ChIP-Seq_DLD1_Human1.03395637
100CREB1_15753290_ChIP-ChIP_HEK293T_Human1.03308447
101ATF3_27146783_Chip-Seq_COLON_Human1.03258846
102KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03087640
103FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.03077006
104MYC_18358816_ChIP-ChIP_MESCs_Mouse1.03021332
105CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.02616111
106RACK7_27058665_Chip-Seq_MCF-7_Human1.02333611
107STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.02014378
108GATA2_19941826_ChIP-Seq_K562_Human0.98839863
109RUNX1_22412390_ChIP-Seq_EML_Mouse0.98225842
110TP63_17297297_ChIP-ChIP_HaCaT_Human0.97894564
111GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96988176
112SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.96594525
113* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96134369
114* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94325453
115GATA2_21666600_ChIP-Seq_HMVEC_Human0.93954192
116RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93046021
117ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92507681
118ESR2_21235772_ChIP-Seq_MCF-7_Human0.92316439
119FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.91007950
120UTX_26944678_Chip-Seq_JUKART_Human0.90239616
121GATA4_25053715_ChIP-Seq_YYC3_Human0.90090990
122TCF7_22412390_ChIP-Seq_EML_Mouse0.89143453
123HIF1A_21447827_ChIP-Seq_MCF-7_Human0.88903748
124MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.87469010
125KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.87209342
126TFEB_21752829_ChIP-Seq_HELA_Human0.85385862
127MYB_26560356_Chip-Seq_TH2_Human0.85319717
128KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.84966912
129P63_26484246_Chip-Seq_KERATINOCYTES_Human0.84212429
130* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.83627280
131* SOX2_20726797_ChIP-Seq_SW620_Human0.83387183
132HNF4A_19822575_ChIP-Seq_HepG2_Human0.83134159
133GATA6_25053715_ChIP-Seq_YYC3_Human0.82160972
134MYB_26560356_Chip-Seq_TH1_Human0.82006281
135ESR1_21235772_ChIP-Seq_MCF-7_Human0.81596543
136* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81436141
137RUNX_20019798_ChIP-Seq_JUKART_Human0.81322727
138LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.80058156
139CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78727965
140PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.78667514
141SPI1_23127762_ChIP-Seq_K562_Human0.78369043
142* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78013676
143SPI1_23547873_ChIP-Seq_NB4_Human0.77735968
144P300_27058665_Chip-Seq_ZR-75-30cells_Human0.77604951

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.86667612
2MP0005360_urolithiasis4.17912047
3MP0005365_abnormal_bile_salt3.69017886
4MP0009840_abnormal_foam_cell3.56884773
5MP0005085_abnormal_gallbladder_physiolo3.30104276
6MP0010329_abnormal_lipoprotein_level2.79114161
7MP0003191_abnormal_cellular_cholesterol2.70459312
8MP0008875_abnormal_xenobiotic_pharmacok2.58234195
9MP0008438_abnormal_cutaneous_collagen2.54380568
10MP0003252_abnormal_bile_duct2.51280143
11MP0005058_abnormal_lysosome_morphology2.41798081
12MP0003806_abnormal_nucleotide_metabolis2.40533159
13MP0005670_abnormal_white_adipose2.21031304
14MP0005083_abnormal_biliary_tract2.20726945
15MP0003705_abnormal_hypodermis_morpholog2.20066637
16MP0003195_calcinosis2.19479700
17MP0005451_abnormal_body_composition2.16981157
18MP0004264_abnormal_extraembryonic_tissu2.08958377
19MP0001666_abnormal_nutrient_absorption2.04079696
20MP0003300_gastrointestinal_ulcer2.01713174
21MP0004782_abnormal_surfactant_physiolog1.96223841
22MP0000609_abnormal_liver_physiology1.95114030
23MP0002796_impaired_skin_barrier1.92112070
24MP0005332_abnormal_amino_acid1.89971760
25MP0002118_abnormal_lipid_homeostasis1.84707968
26MP0003656_abnormal_erythrocyte_physiolo1.83043609
27MP0000858_altered_metastatic_potential1.81827491
28MP0002877_abnormal_melanocyte_morpholog1.76659769
29MP0003453_abnormal_keratinocyte_physiol1.75313796
30MP0003763_abnormal_thymus_physiology1.72297360
31MP0004233_abnormal_muscle_weight1.64657927
32MP0005666_abnormal_adipose_tissue1.60670418
33MP0009643_abnormal_urine_homeostasis1.59837964
34MP0002138_abnormal_hepatobiliary_system1.59155175
35MP0004130_abnormal_muscle_cell1.56364682
36MP0010352_gastrointestinal_tract_polyps1.52429138
37MP0005319_abnormal_enzyme/_coenzyme1.50180073
38MP0001216_abnormal_epidermal_layer1.49592737
39MP0005076_abnormal_cell_differentiation1.49280673
40MP0009333_abnormal_splenocyte_physiolog1.46308217
41MP0000604_amyloidosis1.45787743
42MP0003436_decreased_susceptibility_to1.44860430
43MP0005501_abnormal_skin_physiology1.44849818
44MP0004185_abnormal_adipocyte_glucose1.42378682
45MP0010155_abnormal_intestine_physiology1.40849869
46MP0003186_abnormal_redox_activity1.39611265
47MP0003868_abnormal_feces_composition1.38331710
48MP0002148_abnormal_hypersensitivity_rea1.38262971
49MP0005584_abnormal_enzyme/coenzyme_acti1.36427969
50MP0001873_stomach_inflammation1.35128605
51MP0008260_abnormal_autophagy1.33777378
52MP0005464_abnormal_platelet_physiology1.32059247
53MP0006054_spinal_hemorrhage1.31649299
54MP0003724_increased_susceptibility_to1.30120084
55MP0003221_abnormal_cardiomyocyte_apopto1.29991513
56MP0005275_abnormal_skin_tensile1.27468211
57MP0004019_abnormal_vitamin_homeostasis1.26240226
58MP0003091_abnormal_cell_migration1.25257120
59MP0002971_abnormal_brown_adipose1.25084169
60MP0003950_abnormal_plasma_membrane1.24833466
61MP0005220_abnormal_exocrine_pancreas1.24748486
62MP0001800_abnormal_humoral_immune1.23926787
63MP0003172_abnormal_lysosome_physiology1.22867340
64MP0005375_adipose_tissue_phenotype1.19389962
65MP0002452_abnormal_antigen_presenting1.16457109
66MP0008469_abnormal_protein_level1.16279266
67MP0002254_reproductive_system_inflammat1.15796907
68MP0003828_pulmonary_edema1.15362862
69MP0000465_gastrointestinal_hemorrhage1.14682578
70MP0000013_abnormal_adipose_tissue1.14484356
71MP0000598_abnormal_liver_morphology1.13836933
72MP0001533_abnormal_skeleton_physiology1.12357829
73MP0002078_abnormal_glucose_homeostasis1.11844519
74MP0002723_abnormal_immune_serum1.11123697
75MP0005334_abnormal_fat_pad1.10443659
76MP0001727_abnormal_embryo_implantation1.08294240
77MP0000685_abnormal_immune_system1.07378638
78MP0004808_abnormal_hematopoietic_stem1.06862129
79MP0002332_abnormal_exercise_endurance1.06398731
80MP0009764_decreased_sensitivity_to1.05533231
81MP0000627_abnormal_mammary_gland1.04248398
82MP0002420_abnormal_adaptive_immunity1.03769702
83MP0001819_abnormal_immune_cell1.03610023
84MP0005636_abnormal_mineral_homeostasis1.03475605
85MP0002006_tumorigenesis1.01872080
86MP0001835_abnormal_antigen_presentation1.01031205
87MP0003448_altered_tumor_morphology1.00175247
88MP0002419_abnormal_innate_immunity0.99420142
89MP0003566_abnormal_cell_adhesion0.99345118
90MP0009763_increased_sensitivity_to0.99330133
91MP0001851_eye_inflammation0.98443275
92MP0000490_abnormal_crypts_of0.97887519
93MP0004510_myositis0.96314122
94MP0004947_skin_inflammation0.96016394
95MP0006082_CNS_inflammation0.95213871
96MP0001881_abnormal_mammary_gland0.95114709
97MP0003690_abnormal_glial_cell0.94668128
98MP0001756_abnormal_urination0.94643734
99MP0001944_abnormal_pancreas_morphology0.93811784
100MP0002398_abnormal_bone_marrow0.93497444
101MP0001845_abnormal_inflammatory_respons0.91813686
102MP0003075_altered_response_to0.91641455
103MP0003303_peritoneal_inflammation0.90881003
104MP0003329_amyloid_beta_deposits0.90594547
105MP0005023_abnormal_wound_healing0.89642780
106MP0001764_abnormal_homeostasis0.88425163
107MP0005165_increased_susceptibility_to0.87199516
108MP0002098_abnormal_vibrissa_morphology0.86780493
109MP0002166_altered_tumor_susceptibility0.86728741
110MP0002722_abnormal_immune_system0.86625658
111MP0003279_aneurysm0.86242897
112MP0004957_abnormal_blastocyst_morpholog0.86217098
113MP0001243_abnormal_dermal_layer0.85773306
114MP0000716_abnormal_immune_system0.85623079
115MP0005025_abnormal_response_to0.85525876
116MP0001853_heart_inflammation0.85363811
117MP0005387_immune_system_phenotype0.85212696
118MP0001790_abnormal_immune_system0.85212696
119MP0009642_abnormal_blood_homeostasis0.85135798
120MP0005408_hypopigmentation0.84753510
121MP0009785_altered_susceptibility_to0.84312753
122MP0005621_abnormal_cell_physiology0.84236797
123MP0002396_abnormal_hematopoietic_system0.84108342
124MP0002693_abnormal_pancreas_physiology0.83937902
125MP0002405_respiratory_system_inflammati0.83642283
126MP0005671_abnormal_response_to0.83539654
127MP0002909_abnormal_adrenal_gland0.83308196
128MP0010368_abnormal_lymphatic_system0.81928484
129MP0009931_abnormal_skin_appearance0.81829067
130MP0002136_abnormal_kidney_physiology0.81508197
131MP0000689_abnormal_spleen_morphology0.80958647
132MP0000003_abnormal_adipose_tissue0.80315807
133MP0000343_altered_response_to0.80254789
134MP0005257_abnormal_intraocular_pressure0.78896436
135MP0009115_abnormal_fat_cell0.77939835
136MP0010678_abnormal_skin_adnexa0.77911317
137MP0005535_abnormal_body_temperature0.77386606
138MP0002429_abnormal_blood_cell0.77119708
139MP0002060_abnormal_skin_morphology0.75290875
140MP0002837_dystrophic_cardiac_calcinosis0.74025417
141MP0009780_abnormal_chondrocyte_physiolo0.72989048
142MP0002970_abnormal_white_adipose0.72782223
143MP0005000_abnormal_immune_tolerance0.72716226
144MP0004043_abnormal_pH_regulation0.71505238
145MP0006036_abnormal_mitochondrial_physio0.70916774
146MP0003183_abnormal_peptide_metabolism0.70800898
147MP0005164_abnormal_response_to0.70225556
148MP0001661_extended_life_span0.68768870
149MP0000249_abnormal_blood_vessel0.68259959
150MP0003959_abnormal_lean_body0.68158594
151MP0002998_abnormal_bone_remodeling0.67888146
152MP0010234_abnormal_vibrissa_follicle0.67788137
153MP0005448_abnormal_energy_balance0.65330121

Predicted human phenotypes

RankGene SetZ-score
1Xanthomatosis (HP:0000991)4.68323753
2Abnormality of aromatic amino acid family metabolism (HP:0004338)4.48458451
3Deep venous thrombosis (HP:0002625)4.30948138
4Intrahepatic cholestasis (HP:0001406)4.05090831
5Complement deficiency (HP:0004431)4.04233654
6Hypoglycemic coma (HP:0001325)3.76583652
7Hyperlipoproteinemia (HP:0010980)3.68182180
8Abnormality of monocarboxylic acid metabolism (HP:0010996)3.60212857
9Abnormality of the common coagulation pathway (HP:0010990)3.49994715
10Abnormality of glycolipid metabolism (HP:0010969)3.46865377
11Abnormality of liposaccharide metabolism (HP:0010968)3.46865377
12Abnormality of glycosphingolipid metabolism (HP:0004343)3.46865377
13Ketosis (HP:0001946)3.41908272
14Systemic lupus erythematosus (HP:0002725)3.37388278
15Dysostosis multiplex (HP:0000943)3.32817476
16Prolonged partial thromboplastin time (HP:0003645)3.31661038
17Ketoacidosis (HP:0001993)3.20793096
18Mucopolysacchariduria (HP:0008155)3.20167004
19Urinary glycosaminoglycan excretion (HP:0003541)3.20167004
20Abnormality of complement system (HP:0005339)3.18057918
21Hypoalphalipoproteinemia (HP:0003233)3.07374279
22Abnormality of the intrinsic pathway (HP:0010989)3.06384831
23J-shaped sella turcica (HP:0002680)3.05496384
24Myocardial infarction (HP:0001658)3.01744704
25Hyperammonemia (HP:0001987)2.98574565
26Hypobetalipoproteinemia (HP:0003563)2.96867116
27Abnormality of glutamine family amino acid metabolism (HP:0010902)2.96209181
28Vertebral compression fractures (HP:0002953)2.94517190
29Hypolipoproteinemia (HP:0010981)2.88487570
30Abnormality of polysaccharide metabolism (HP:0011012)2.86085585
31Abnormality of glycosaminoglycan metabolism (HP:0004371)2.86085585
32Abnormality of mucopolysaccharide metabolism (HP:0011020)2.86085585
33Joint hemorrhage (HP:0005261)2.82943752
34Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.80603040
35Hyperglycinuria (HP:0003108)2.75783410
36Hypoglycemic seizures (HP:0002173)2.73886040
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.71583002
38Abnormality of fatty-acid metabolism (HP:0004359)2.70250933
39Abnormality of glycine metabolism (HP:0010895)2.69751132
40Abnormality of serine family amino acid metabolism (HP:0010894)2.69751132
41Abnormality of sulfur amino acid metabolism (HP:0004339)2.64846344
42Epidermoid cyst (HP:0200040)2.64096053
43Vacuolated lymphocytes (HP:0001922)2.62613475
44Right ventricular cardiomyopathy (HP:0011663)2.57120043
45Insidious onset (HP:0003587)2.55065362
46Termporal pattern (HP:0011008)2.55065362
47Late onset (HP:0003584)2.54298043
48Hypercholesterolemia (HP:0003124)2.54091369
49Skin nodule (HP:0200036)2.52009122
50Loss of speech (HP:0002371)2.46863648
51Hydroxyprolinuria (HP:0003080)2.45405856
52Abnormality of proline metabolism (HP:0010907)2.45405856
53Acanthocytosis (HP:0001927)2.42119498
54Hyperglycinemia (HP:0002154)2.41715988
55Hyperinsulinemic hypoglycemia (HP:0000825)2.37829126
56Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.36107328
57Glomerulonephritis (HP:0000099)2.35128150
58Abnormality of aspartate family amino acid metabolism (HP:0010899)2.34856235
59Flat acetabular roof (HP:0003180)2.34746235
60Fat malabsorption (HP:0002630)2.34680548
61Hyperbilirubinemia (HP:0002904)2.34041136
62Abnormality of purine metabolism (HP:0004352)2.30994320
63Abnormality of methionine metabolism (HP:0010901)2.28971607
64Tetraparesis (HP:0002273)2.24904382
65Recurrent gram-negative bacterial infections (HP:0005420)2.24389707
66Fatigue (HP:0012378)2.23209795
67Osteolytic defects of the hand bones (HP:0009699)2.22976735
68Osteolytic defects of the phalanges of the hand (HP:0009771)2.22976735
69Sparse lateral eyebrow (HP:0005338)2.22528857
70Peritonitis (HP:0002586)2.21857173
71Abnormality of the distal phalanges of the toes (HP:0010182)2.19111759
72Menorrhagia (HP:0000132)2.19006473
73Increased cerebral lipofuscin (HP:0011813)2.18504745
74Distal lower limb muscle weakness (HP:0009053)2.16543992
75Amyloidosis (HP:0011034)2.15878418
76Generalized aminoaciduria (HP:0002909)2.13851037
77Protuberant abdomen (HP:0001538)2.10073953
78Hypertriglyceridemia (HP:0002155)2.08325661
79Global brain atrophy (HP:0002283)2.08323171
80Abnormality of transition element cation homeostasis (HP:0011030)2.07657488
81Back pain (HP:0003418)2.07579823
82Hyperparathyroidism (HP:0000843)2.07127175
83Abnormality of oral frenula (HP:0000190)2.06211960
84Abnormality of dicarboxylic acid metabolism (HP:0010995)2.05878402
85Dicarboxylic aciduria (HP:0003215)2.05878402
86Distal lower limb amyotrophy (HP:0008944)2.05000384
87Gingival bleeding (HP:0000225)2.03629401
88Pancreatitis (HP:0001733)2.02266922
89Hepatocellular carcinoma (HP:0001402)2.01736839
90Growth hormone excess (HP:0000845)1.98158178
91Abnormal gallbladder morphology (HP:0012437)1.97368995
92Mitral stenosis (HP:0001718)1.97088365
93Achilles tendon contracture (HP:0001771)1.96996772
94Onycholysis (HP:0001806)1.96595742
95Increased neuronal autofluorescent lipopigment (HP:0002074)1.96404282
96Spinal cord lesions (HP:0100561)1.96128754
97Syringomyelia (HP:0003396)1.96128754
98Bone pain (HP:0002653)1.94908846
99Abnormality of iron homeostasis (HP:0011031)1.94725649
100Eczematoid dermatitis (HP:0000976)1.94507530
101Polycythemia (HP:0001901)1.94335212
102Autoimmune hemolytic anemia (HP:0001890)1.94235367
103Spondylolisthesis (HP:0003302)1.94177896
104Symptomatic seizures (HP:0011145)1.92184625
105Sensorimotor neuropathy (HP:0007141)1.92011605
106Cerebral aneurysm (HP:0004944)1.91914210
107Abnormality of nucleobase metabolism (HP:0010932)1.91025578
108Asymmetric septal hypertrophy (HP:0001670)1.90887517
109Oligomenorrhea (HP:0000876)1.90345188
110Hyperglycemia (HP:0003074)1.89369639
111Abnormality of the Achilles tendon (HP:0005109)1.89134464
112Cholelithiasis (HP:0001081)1.88896510
113Premature rupture of membranes (HP:0001788)1.88650398
114Myoglobinuria (HP:0002913)1.88625176
115Abnormal cartilage morphology (HP:0002763)1.88392210
116Insulin resistance (HP:0000855)1.87098177
117Increased serum ferritin (HP:0003281)1.86802790
118Elevated alkaline phosphatase (HP:0003155)1.85113276
119Thin bony cortex (HP:0002753)1.85041593
120Upper limb amyotrophy (HP:0009129)1.85004982
121Distal upper limb amyotrophy (HP:0007149)1.85004982
122Esophageal varix (HP:0002040)1.84994578
123Abnormality of macrophages (HP:0004311)1.84813139
124Protrusio acetabuli (HP:0003179)1.82994659
125Metabolic acidosis (HP:0001942)1.82989298
126Centrally nucleated skeletal muscle fibers (HP:0003687)1.82728643
127Nail dystrophy (HP:0008404)1.82634457
128Curly hair (HP:0002212)1.81608273
129Autoamputation (HP:0001218)1.80265669
130Axonal loss (HP:0003447)1.80223556
131Interstitial pulmonary disease (HP:0006530)1.79889888
132Reduced antithrombin III activity (HP:0001976)1.79558992
133Hemorrhage of the eye (HP:0011885)1.78915734
134Nephritis (HP:0000123)1.77634851
135Cervical subluxation (HP:0003308)1.76597016
136Acute hepatic failure (HP:0006554)1.76512686
137Microglossia (HP:0000171)1.76430847
138Abnormal enzyme/coenzyme activity (HP:0012379)1.76214590
139Conjugated hyperbilirubinemia (HP:0002908)1.75874418
140Spastic diplegia (HP:0001264)1.75104750
141Alopecia of scalp (HP:0002293)1.74839016
142Micronodular cirrhosis (HP:0001413)1.74381962
143Beaking of vertebral bodies (HP:0004568)1.73475643
144Gout (HP:0001997)1.72976149
145Abnormality of the thoracic spine (HP:0100711)1.72227926
146Entropion (HP:0000621)1.70417675
147Thoracic kyphosis (HP:0002942)1.70279158
148Microretrognathia (HP:0000308)1.68869613
149Chronic diarrhea (HP:0002028)1.68638728
150Abnormality of alkaline phosphatase activity (HP:0004379)1.67129149
151Deformed sella turcica (HP:0002681)1.66743868
152Spinal rigidity (HP:0003306)1.65862785
153Hand muscle atrophy (HP:0009130)1.65602120
154Atrophic scars (HP:0001075)1.64903942
155Upper limb muscle weakness (HP:0003484)1.64237765
156Short nail (HP:0001799)1.62860126
157Coarse hair (HP:0002208)1.61375473
158Erythema (HP:0010783)1.59168200
159Thick nail (HP:0001805)1.58949274
160Increased IgM level (HP:0003496)1.58812764
161Increased connective tissue (HP:0009025)1.58786916
162Abnormality of the gastric mucosa (HP:0004295)1.58123532
163Ridged nail (HP:0001807)1.57440121
164Hepatosplenomegaly (HP:0001433)1.57311765
165Ankyloglossia (HP:0010296)1.56583774
166Abdominal distention (HP:0003270)1.56548439
167Ragged-red muscle fibers (HP:0003200)1.56076484
168Abnormal gallbladder physiology (HP:0012438)1.55685341
169Cholecystitis (HP:0001082)1.55685341
170Absent frontal sinuses (HP:0002688)1.55224939
171T lymphocytopenia (HP:0005403)1.54334579
172Severe short stature (HP:0003510)1.54199962
173Progressive neurologic deterioration (HP:0002344)1.54081016
174Abnormal foot bone ossification (HP:0010675)1.53659713
175Gastrointestinal stroma tumor (HP:0100723)1.53033714
176Urticaria (HP:0001025)1.51201362

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.32681074
2TRIB34.79603498
3BCKDK3.41701707
4PKN23.10769220
5SIK12.72861580
6TAOK32.66916266
7PRPF4B2.65715065
8EPHA22.65607838
9SIK32.37744474
10FLT32.37113816
11FGFR42.25215933
12CDK122.21984403
13TYK21.91232816
14TBK11.90124031
15INSRR1.89865662
16SCYL21.89520578
17TESK21.88038638
18TGFBR21.85927665
19EIF2AK11.85205880
20PTK61.75637730
21EPHB11.73493909
22TAOK21.71200371
23PIK3CG1.69475211
24MST1R1.65308251
25PIM21.60074236
26MAP3K101.54287661
27NME21.52938899
28IRAK31.51514714
29LRRK21.50198455
30RIPK11.48194184
31MATK1.47514047
32JAK11.47306039
33MAP4K11.43463452
34MET1.39439412
35EEF2K1.36989784
36CAMK1D1.36222302
37JAK31.29088941
38TTN1.24430678
39CSF1R1.23864077
40SMG11.22570868
41NEK91.20799662
42JAK21.20722486
43BMX1.17897768
44MAP3K31.17453471
45ZAP701.13085579
46FRK1.12684142
47MAP3K21.12498172
48ARAF1.10650040
49MAP2K31.10619382
50MAP3K61.09495948
51ICK1.09186932
52PDGFRA1.08033085
53KIT1.07820924
54RPS6KB21.02464772
55KDR1.02351465
56MAPK151.02330298
57IRAK40.90933114
58EPHA30.87850657
59ITK0.85803636
60CSK0.84760965
61STK100.84444225
62RET0.83153434
63MST40.82826439
64CDK80.81402071
65PBK0.80646409
66MAPK110.80294595
67PTK20.80005516
68MAP2K20.79429830
69GRK60.78031772
70HIPK20.77646911
71TAOK10.77251468
72IKBKE0.77115077
73MAP3K140.71372536
74BCR0.70777374
75ERBB30.70591320
76NEK60.70555312
77BTK0.69989421
78FGFR30.67693806
79MAPKAPK30.67522423
80MAP3K120.65795503
81EIF2AK20.65639766
82MAP3K10.64778785
83PRKAA20.63064471
84SRPK10.63038737
85MAP3K50.62641818
86CDK70.62369895
87IKBKB0.61400430
88CAMKK20.61377897
89DDR20.60684421
90CLK10.60361626
91TEC0.59204318
92YES10.59167566
93LMTK20.58544986
94DYRK1B0.58399841
95CDK60.57209943
96PASK0.57003253
97PRKG20.56853796
98MAP3K110.56736794
99ABL20.56697259
100GSK3A0.55578614
101CHUK0.55577900
102MAPKAPK20.55223749
103CAMK1G0.54054579
104BLK0.53156836
105PDPK10.52755399
106CDK40.52317539
107PRKCH0.51817551
108MAP2K10.51415880
109IRAK10.51329337
110MAP3K130.50708318
111RPS6KA40.49357791
112NTRK10.49197750
113KSR20.48604522
114PRKCI0.48581295
115IGF1R0.48581258
116PAK40.46483603
117HCK0.46438715
118TESK10.46233479
119PAK20.46216209
120ERBB40.45816661
121PRKD20.45110784
122CDK90.42700394
123EIF2AK30.41841929
124TRPM70.41530489
125EGFR0.40708013
126PDK10.40069886
127MAP3K70.39275858
128LATS20.38635848
129MTOR0.38165678
130PRKD10.37913563
131RIPK40.37834518
132LCK0.37446996
133LIMK10.36463188
134SYK0.36149455
135PDGFRB0.35603081
136LYN0.35301676
137TRIM280.34581892
138MAP3K80.33751098
139STK380.33431530
140STK30.33378313
141TIE10.33192739
142BRAF0.32414956
143ILK0.32196051
144MUSK0.31967098
145TTK0.31861100
146NLK0.31466794
147MYLK0.31430689

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.19661575
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.11157824
3Fatty acid degradation_Homo sapiens_hsa000712.68365997
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.54595192
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.52103194
6Complement and coagulation cascades_Homo sapiens_hsa046102.38976675
7Tryptophan metabolism_Homo sapiens_hsa003802.31183879
8PPAR signaling pathway_Homo sapiens_hsa033202.16701775
9Propanoate metabolism_Homo sapiens_hsa006402.12371778
10Caffeine metabolism_Homo sapiens_hsa002322.10586898
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.09141803
12Staphylococcus aureus infection_Homo sapiens_hsa051502.07398323
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.06945530
14Fatty acid metabolism_Homo sapiens_hsa012122.05807615
15Arginine biosynthesis_Homo sapiens_hsa002202.03211813
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.96792624
17Pentose and glucuronate interconversions_Homo sapiens_hsa000401.94244315
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.90313718
19Selenocompound metabolism_Homo sapiens_hsa004501.85325762
20Sulfur metabolism_Homo sapiens_hsa009201.81426928
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.79350881
22Peroxisome_Homo sapiens_hsa041461.78430927
23Shigellosis_Homo sapiens_hsa051311.77142702
24Acute myeloid leukemia_Homo sapiens_hsa052211.62056211
25Fat digestion and absorption_Homo sapiens_hsa049751.57327699
26Pancreatic cancer_Homo sapiens_hsa052121.57104103
27Folate biosynthesis_Homo sapiens_hsa007901.55199147
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.55088336
29Histidine metabolism_Homo sapiens_hsa003401.50500395
30Butanoate metabolism_Homo sapiens_hsa006501.49390998
31beta-Alanine metabolism_Homo sapiens_hsa004101.47726499
32Hepatitis C_Homo sapiens_hsa051601.47436236
33Starch and sucrose metabolism_Homo sapiens_hsa005001.47405557
34NF-kappa B signaling pathway_Homo sapiens_hsa040641.43952430
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.43730581
36Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.43217612
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.41644499
38Measles_Homo sapiens_hsa051621.40559120
39Vibrio cholerae infection_Homo sapiens_hsa051101.38445168
40Bladder cancer_Homo sapiens_hsa052191.38303057
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.37667249
42B cell receptor signaling pathway_Homo sapiens_hsa046621.37654721
43TNF signaling pathway_Homo sapiens_hsa046681.35165948
44Lysosome_Homo sapiens_hsa041421.33916901
45Chronic myeloid leukemia_Homo sapiens_hsa052201.33001714
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.31958927
47ABC transporters_Homo sapiens_hsa020101.31660484
48Drug metabolism - other enzymes_Homo sapiens_hsa009831.31607273
49Influenza A_Homo sapiens_hsa051641.30470947
50* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.27480768
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.27122061
52Hepatitis B_Homo sapiens_hsa051611.25310128
53Viral myocarditis_Homo sapiens_hsa054161.22100689
54Herpes simplex infection_Homo sapiens_hsa051681.21966362
55Carbon metabolism_Homo sapiens_hsa012001.21630418
56Pyruvate metabolism_Homo sapiens_hsa006201.21392016
57Other glycan degradation_Homo sapiens_hsa005111.20444826
58Chemical carcinogenesis_Homo sapiens_hsa052041.18449814
59Protein export_Homo sapiens_hsa030601.17425308
60Sulfur relay system_Homo sapiens_hsa041221.17161465
61Apoptosis_Homo sapiens_hsa042101.14626996
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.12993991
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.12726910
64T cell receptor signaling pathway_Homo sapiens_hsa046601.12295281
65Bile secretion_Homo sapiens_hsa049761.09799015
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.09449340
67Thyroid cancer_Homo sapiens_hsa052161.08838619
68Fatty acid biosynthesis_Homo sapiens_hsa000611.08378371
69Non-small cell lung cancer_Homo sapiens_hsa052231.06628420
70Phenylalanine metabolism_Homo sapiens_hsa003601.05200396
71Central carbon metabolism in cancer_Homo sapiens_hsa052301.04033147
72Fatty acid elongation_Homo sapiens_hsa000621.03757047
73Biosynthesis of amino acids_Homo sapiens_hsa012301.02859191
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.02842150
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.01799397
76Glycerolipid metabolism_Homo sapiens_hsa005611.00926514
77Tuberculosis_Homo sapiens_hsa051520.99150784
78Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98446758
79Salmonella infection_Homo sapiens_hsa051320.95352030
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.93163127
81Tyrosine metabolism_Homo sapiens_hsa003500.92842170
82Sphingolipid metabolism_Homo sapiens_hsa006000.92597813
83Renal cell carcinoma_Homo sapiens_hsa052110.92387772
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.92375293
85Small cell lung cancer_Homo sapiens_hsa052220.91877280
86Steroid biosynthesis_Homo sapiens_hsa001000.91375295
87Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89655120
88Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.89568809
89Viral carcinogenesis_Homo sapiens_hsa052030.88074965
90Pentose phosphate pathway_Homo sapiens_hsa000300.88027842
91Graft-versus-host disease_Homo sapiens_hsa053320.88015088
92Allograft rejection_Homo sapiens_hsa053300.86152780
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84968984
94Arginine and proline metabolism_Homo sapiens_hsa003300.83591786
95Retinol metabolism_Homo sapiens_hsa008300.82836488
96Insulin resistance_Homo sapiens_hsa049310.81947053
97Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81739342
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.80733340
99VEGF signaling pathway_Homo sapiens_hsa043700.80158152
100Galactose metabolism_Homo sapiens_hsa000520.78805136
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.77550502
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76659833
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76370878
104Endocytosis_Homo sapiens_hsa041440.76115451
105Phagosome_Homo sapiens_hsa041450.75189813
106Intestinal immune network for IgA production_Homo sapiens_hsa046720.74583047
107Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.74376048
108Vitamin digestion and absorption_Homo sapiens_hsa049770.73759254
109Cysteine and methionine metabolism_Homo sapiens_hsa002700.72584760
110Epstein-Barr virus infection_Homo sapiens_hsa051690.72057665
111Primary immunodeficiency_Homo sapiens_hsa053400.71984597
112Endometrial cancer_Homo sapiens_hsa052130.67332133
113Jak-STAT signaling pathway_Homo sapiens_hsa046300.66523633
114HTLV-I infection_Homo sapiens_hsa051660.64158144
115Proteoglycans in cancer_Homo sapiens_hsa052050.64094853
116Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.63696166
117Prion diseases_Homo sapiens_hsa050200.62536504
118Autoimmune thyroid disease_Homo sapiens_hsa053200.61018082
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59868490
120Lysine degradation_Homo sapiens_hsa003100.58803362
121Rheumatoid arthritis_Homo sapiens_hsa053230.58553975
122N-Glycan biosynthesis_Homo sapiens_hsa005100.58212122
123Hematopoietic cell lineage_Homo sapiens_hsa046400.58108214
124Prolactin signaling pathway_Homo sapiens_hsa049170.57445314
125Neurotrophin signaling pathway_Homo sapiens_hsa047220.56944278
126Proteasome_Homo sapiens_hsa030500.56491407
127Glutathione metabolism_Homo sapiens_hsa004800.55535180
128Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54969115
129Prostate cancer_Homo sapiens_hsa052150.54013044
130Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53356327
131ErbB signaling pathway_Homo sapiens_hsa040120.52060650
132One carbon pool by folate_Homo sapiens_hsa006700.51768314
133Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51389229
134Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50338172
135Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46139505
136AMPK signaling pathway_Homo sapiens_hsa041520.46018834
137Legionellosis_Homo sapiens_hsa051340.45318871
138Fructose and mannose metabolism_Homo sapiens_hsa000510.43848371
139Malaria_Homo sapiens_hsa051440.38928236
140Antigen processing and presentation_Homo sapiens_hsa046120.38432451
141Protein digestion and absorption_Homo sapiens_hsa049740.33776154
142alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33329425
143Metabolic pathways_Homo sapiens_hsa011000.33247049
144Cyanoamino acid metabolism_Homo sapiens_hsa004600.31931347
145Osteoclast differentiation_Homo sapiens_hsa043800.31809486
146Pertussis_Homo sapiens_hsa051330.31428880
147Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.31047815
148Renin-angiotensin system_Homo sapiens_hsa046140.30768944
149Leishmaniasis_Homo sapiens_hsa051400.28238991
150Linoleic acid metabolism_Homo sapiens_hsa005910.24854626
151Insulin signaling pathway_Homo sapiens_hsa049100.24807139
152Amoebiasis_Homo sapiens_hsa051460.24659685
153Vitamin B6 metabolism_Homo sapiens_hsa007500.22732413
154Toll-like receptor signaling pathway_Homo sapiens_hsa046200.21600553
155Glucagon signaling pathway_Homo sapiens_hsa049220.20380219
156Glycerophospholipid metabolism_Homo sapiens_hsa005640.20277889
157Toxoplasmosis_Homo sapiens_hsa051450.18976508

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